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Artykuły w czasopismach na temat „CEFR-V”

Autor: Grafiati
Data publikacji: 3 czerwca 2025
Data aktualizacji: 31 lipca 2025

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1

Hidayah, Kabul. "Cefr-Based Mahara Al-Kitabah Competencis in Class V Textbooks at Madrasah Tsanawiyah Level in Indonesia." Edumaspul: Jurnal Pendidikan 7, no. 2 (2023): 2922–31. http://dx.doi.org/10.33487/edumaspul.v7i2.6809.

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In Indonesia, the achievement standards for learning Arabic in Maharah Al-Kitabah are core competencies and basic competencies in each sub- and sub-sab in the teaching materials used, while in international forums the reference used is the Common European Framework of Reference for Language (CEFR). Competency standards are divided into several levels and can be modified according to the level of ability of students. In addition, the CEFR is also equipped with an assessment instrument to measure the development of students' abilities in all language skills, namely maharah istima', kalam, qiroah
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2

Hořká, Zuzana. "Distanční výuka - krok vpřed nebo krok vzad?" CASALC Review 11, no. 1 (2021): 22. http://dx.doi.org/10.5817/casalc2021-1-2.

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Přechod na distanční výuku znovu otevřel otázku metodiky výuky cizích jazyků. Zimní semestr 2020/21 proběhl celý on-line, což se stalo výzvou zejména pro studenty prvních ročníků, kteří museli zvládnout přechod na zcela jinou formu studia, aniž by se mohli osobně seznámit s vysokoškolským prostředím. Vedení Matematicko-fyzikální fakulty se vzhledem k situaci na jaře 2020 rozhodlo přijmout všechny zájemce o studium bez přijímacích zkoušek, což do prvního ročníku přivedlo české i zahraniční studenty se značnými rozdíly ve znalosti angličtiny. Situace byla nová i pro vyučující, kteří přišli o mož
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3

Hulstijn, Jan H. "The Common European Framework of Reference for Languages." ITL - International Journal of Applied Linguistics 165, no. 1 (2014): 3–18. http://dx.doi.org/10.1075/itl.165.1.01hul.

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The Common European Framework of Reference for Languages (CEFR, Council of Europe, 2001) currently functions as an instrument for educational policy and practice. The view of language proficiency on which it is based and the six proficiency levels it defines lack empirical support from language-use data. Several issues need to be investigated collaboratively by researchers working in the fields of first and second language acquisition, corpus linguistics and language assessment. These issues are concerned with (i) the CEFR’s failure to consistently distinguish between levels of language profic
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4

Trihardini, Ayu, Aprilia Ruby Wikarti, Deaneira Cantika Islami, Nurul Hanifah, and Ferdinand Hironimus. "KESETARAAN HANYU SHUIPING KAOSHI LEVEL V-VI DENGAN CEFR PADA KETERAMPILAN BERBICARA BAHASA MANDARIN." Jurnal Cakrawala Mandarin 7, no. 1 (2023): 36. http://dx.doi.org/10.36279/apsmi.v7i1.262.

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5

Еременко, И. О., та А. В. Ерёменко. "Теоретические основания содержания тестирования: структура коммуникативной компетенции". Pedagogical perspective, № 3(19) (9 червня 2025): 52–65. https://doi.org/10.55523/27822559_2025_3(19)_52.

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Формирование и оценка иноязычной коммуникативной компетенции в современном образовании рассматриваются как ключевые задачи, продиктованные глобализацией и необходимостью эффективного межкультурного взаимодействия. В статье раскрываются теоретические основы понятия «коммуникативная компетенция», анализируются наиболее влиятельные зарубежные и отечественные модели её структуры (Д. Хаймс, М. Канале и М. Суэйн, В. Эк, И.Л. Бим, Л.Ф. Бахман и А.С. Палмер), подчёркивается роль прагматической составляющей в продуктивной устной речи. Особое внимание уделено европейской системе CEFR как инструменту объ
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6

Karsenti, Thierry, and Simon Collin. "EDUPORTFOLIO: A TOOL FOR SECOND LANGUAGE TEACHERS." Revista Diálogo Educacional 10, no. 31 (2010): 581. http://dx.doi.org/10.7213/rde.v10i31.2431.

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Originally used in artistic circles, the portfolio has gained considerable ground in the education field, where it serves a multitude of functions, both academic and professional. It is also a rapidly evolving tool, notably due to advances in Web 2.0 technology that have opened the way to new pedagogical potentials. The portfolio is also prominent in second-language teaching and learning programs, as witnessed by the European Language Portfolio (ELP), which was developed and piloted by the Council of Europe and is used as a support tool in line with the ISSN 1518-3483 Licenciado sob uma Licenç
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7

Fiřtová, Lenka. "SCATE (Scio Computer Adaptive Test) Nová role testu." TESTFÓRUM 5, no. 7 (2016): 41–51. http://dx.doi.org/10.5817/tf2016-7-96.

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Adaptivní testování na počítačích podporuje individualizaci, zajímavé a interaktivní typy úloh a výsledky mohou být použity k vytvoření učebního plánu na míru. Scio přistoupilo k vývoji adaptivních testů v roce 2011. Adaptivní test z anglického jazyka byl jedním z prvních. Úkolem bylo vytvořit množství úloh, které pokrývají všechny úrovně CEFR. Navíc jsme vytvářeli i úlohy pro úplné začátečníky, jež jsme označili úrovní A0. Úlohy byly zařazeny do kategorií a byly pilotovány na několika stovkách lidí, u kterých byla prokázána úroveň angličtiny (čerství držitelé certifikátů např. FCE, CAE, TOEFL
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8

Römer, Ute, and Cynthia M. Berger. "OBSERVING THE EMERGENCE OF CONSTRUCTIONAL KNOWLEDGE." Studies in Second Language Acquisition 41, no. 5 (2019): 1089–110. http://dx.doi.org/10.1017/s0272263119000202.

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AbstractBased on writing produced by second language learners at different proficiency levels (CEFR A1 to C1), we adopted a usage-based approach (Ellis, Römer, & O’Donnell, 2016; Tyler & Ortega, 2018) to investigate how German and Spanish learner knowledge of 19 English verb-argument constructions (VACs; e.g., “V with n,” illustrated by he always agrees with her) develops. We extracted VACs from subsets of the Education First-Cambridge Open Language Database, altogether comprising more than 68,000 texts and 6 million words. For each VAC, L1 learner group, and proficiency level, we dete
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9

Ongas, Martin, Joseph Standing, Bernhards Ogutu, Joseph Waichungo, James A. Berkley, and Karin Kipper. "Liquid chromatography–tandem mass spectrometry for the simultaneous quantitation of ceftriaxone, metronidazole and hydroxymetronidazole in plasma from seriously ill, severely malnourished children." Wellcome Open Research 2 (June 19, 2017): 43. http://dx.doi.org/10.12688/wellcomeopenres.11728.1.

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We have developed and validated a novel, sensitive, selective and reproducible reversed-phase high-performance liquid chromatography method coupled with electrospray ionization mass spectrometry (HPLC–ESI-MS/MS) for the simultaneous quantitation of ceftriaxone (CEF), metronidazole (MET) and hydroxymetronidazole (MET-OH) from only 50 µL of human plasma, and unbound CEF from 25 µL plasma ultra-filtrate to evaluate the effect of protein binding. Cefuroxime axetil (CEFU) was used as an internal standard (IS). The analytes were extracted by a protein precipitation procedure with acetonitrile and se
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10

Ongas, Martin, Joseph Standing, Bernhards Ogutu, Joseph Waichungo, James A. Berkley, and Karin Kipper. "Liquid chromatography–tandem mass spectrometry for the simultaneous quantitation of ceftriaxone, metronidazole and hydroxymetronidazole in plasma from seriously ill, severely malnourished children." Wellcome Open Research 2 (January 30, 2018): 43. http://dx.doi.org/10.12688/wellcomeopenres.11728.2.

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We have developed and validated a novel, sensitive, selective and reproducible reversed-phase high-performance liquid chromatography method coupled with electrospray ionization mass spectrometry (HPLC–ESI-MS/MS) for the simultaneous quantitation of ceftriaxone (CEF), metronidazole (MET) and hydroxymetronidazole (MET-OH) from only 50 µL of human plasma, and unbound CEF from 25 µL plasma ultra-filtrate to evaluate the effect of protein binding. Cefuroxime axetil (CEFU) was used as an internal standard (IS). The analytes were extracted by a protein precipitation procedure with acetonitrile and se
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11

Palomino-Tapia, Victor A., Guillermo Zavala, Sunny Cheng, and Maricarmen Garcia. "Attenuation of a Field Strain of Infectious Laryngotracheitis Virus in Primary Chicken Culture Cells and Adaptation to Secondary Chicken Embryo Fibroblasts." Poultry 2, no. 4 (2023): 516–30. http://dx.doi.org/10.3390/poultry2040038.

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The establishment of commercial infectious laryngotracheitis virus (ILTV) live-modified vaccines has relied on serial passaging in chicken embryo (CEO) and tissue culture (TCO) for attenuation. The objective of this study was to attenuate and adapt a virulent CEO-related ILTV field strain (6340) in immortalized cells (LMH), primary chicken embryo kidney cells (CEK), chicken embryo liver cells (CEL), and chicken embryo fibroblasts (CEF). CEFs were refractory to parent ILTV, LMH cells produced low virus yields (~2.5 log10 TCID50 per mL), while CEK and CEL cells produced higher viral titers (≥log
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12

Zhang, Meng-Meng, Da-Yong Fan, Keach Murakami, Murray R. Badger, Guang-Yu Sun, and Wah Soon Chow. "Partially Dissecting Electron Fluxes in Both Photosystems in Spinach Leaf Disks during Photosynthetic Induction." Plant and Cell Physiology 60, no. 10 (2019): 2206–19. http://dx.doi.org/10.1093/pcp/pcz114.

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Abstract Photosynthetic induction, a gradual increase in photosynthetic rate on a transition from darkness or low light to high light, has ecological significance, impact on biomass accumulation in fluctuating light and relevance to photoprotection in strong light. However, the experimental quantification of the component electron fluxes in and around both photosystems during induction has been rare. Combining optimized chlorophyll fluorescence, the redox kinetics of P700 [primary electron donor in Photosystem I (PSI)] and membrane inlet mass spectrometry in the absence/presence of inhibitors/
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13

Yasin, Agus, and Hidia Tarauni. "Tashmim al-Ikhtibar li Maharah al-Kalam al-‘Arabi wafqhan li al-Ithar al-al-Marja’i al-Urubi al-Musytarak li al-Lughat li al-Thullab al-Jami’ah fi Indunisiya." Arabiyatuna: Jurnal Bahasa Arab 7, no. 1 May (2023): 113. http://dx.doi.org/10.29240/jba.v7i1.6390.

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This study aimed to develop a speaking-skill test at the B1 of CEFR, to determine the levels of validity, reliability, and difficulty of each item, and to organize the distinguishing power of each item on the prepared test. This research was motivated by the need of Arabic Language Test as an evaluation activity that required for various purposes. Several universities in Indonesia have also intended the existence of a language test as a requirement for continuing studies to a higher degree or to a place where linguistic proficiency is required or work somewhere. Also, the most important is to
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14

Huguier, Stéphanie, Joël Baguet, Sandrine Perez, Hans van Dam, and Marc Castellazzi. "Transcription Factor ATF2 Cooperates with v-Jun To Promote Growth Factor-Independent Proliferation In Vitro and Tumor Formation In Vivo." Molecular and Cellular Biology 18, no. 12 (1998): 7020–29. http://dx.doi.org/10.1128/mcb.18.12.7020.

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ABSTRACT ATF2 belongs to the bZIP family of transcription factors and controls gene expression via 8-bp ATF/CREB motifs either as a homodimer or as a heterodimer—for instance, with Jun—but has never been shown to be directly involved in oncogenesis. Experiments were designed to evaluate a possible role of ATF2 in oncogenesis in chick embryo fibroblasts (CEFs) in the presence or absence of v-Jun. We found that (i) forced expression of ATF2 cannot alone cause transformation, (ii) overexpression of ATF2 plus v-Jun specifically stimulates v-Jun-induced growth in medium with a reduced amount of ser
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15

Ackland, Stephen P., Antonio Anton, George Peter Breitbach, et al. "Dose-Intensive Epirubicin-Based Chemotherapy Is Superior to an Intensive Intravenous Cyclophosphamide, Methotrexate, and Fluorouracil Regimen in Metastatic Breast Cancer: A Randomized Multinational Study." Journal of Clinical Oncology 19, no. 4 (2001): 943–53. http://dx.doi.org/10.1200/jco.2001.19.4.943.

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PURPOSE: To determine the relative efficacy of a cyclophosphamide epirubicin and fluorouracil (CEF) regimen compared with an intravenous (IV) cyclophosphamide, methotrexate, and fluorouracil (CMF) combination in metastatic breast cancer. PATIENTS AND METHODS: Patients were randomized to receive either CEF (cyclophosphamide 400 mg/m2 IV, epirubicin 50 mg/m2 IV, and fluorouracil 500 mg/m2 IV on days 1 and 8), or CMF (cyclophosphamide 500 mg/m2 IV, methotrexate 40 mg/m2 IV, and fluorouracil 600 mg/m2 IV on days 1 and 8). Treatment was given in 3- to 4-week cycles for a total of six to nine cycles
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16

Conte, P. F., P. Pronzato, A. Rubagotti, et al. "Conventional versus cytokinetic polychemotherapy with estrogenic recruitment in metastatic breast cancer: results of a randomized cooperative trial." Journal of Clinical Oncology 5, no. 3 (1987): 339–47. http://dx.doi.org/10.1200/jco.1987.5.3.339.

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Diethylstilbestrol (DES) can induce a recruitment into the proliferative pool of previously resting breast cancer cells in vivo. In order to verify if estrogenic recruitment could result in a larger tumor cell killing by chemotherapy, 117 patients with metastatic breast cancer were randomized to receive CEF (cyclophosphamide, 600 mg/m2; epidoxorubicin, 60 mg/m2; and 5-fluorouracil, 600 mg/m2 on day 1); DES-CEF (cyclophosphamide, 600 mg/m2 on day 1; DES, 1 mg orally on days 5, 6, and 7; and epidoxorubicin, 60 mg/m2, and 5-fluorouracil, 600 mg/m2, on day 8) every 21 days. No significant differen
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17

Frame, M. C., K. Simpson, V. J. Fincham, and D. H. Crouch. "Separation of v-Src-induced mitogenesis and morphological transformation by inhibition of AP-1." Molecular Biology of the Cell 5, no. 11 (1994): 1177–84. http://dx.doi.org/10.1091/mbc.5.11.1177.

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v-Src activity results in both morphological transformation and reentry of quiescent chick embryo fibroblasts (CEF) into cell cycle. We have previously used temperature-sensitive v-Src mutants to show that enhanced activity of cellular AP-1 in the first few hours after activation of v-Src invariably precedes the biological consequences. Here we have investigated whether the early activation of AP-1 is essential for any or all of the v-Src responses by using a mutant c-Fos that comprises the leucine zipper and a disrupted basic region. Expression of the c-Fos mutant partially reduced cellular A
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18

Park, Man-Seong, Adolfo García-Sastre, Jerome F. Cros, Christopher F. Basler, and Peter Palese. "Newcastle Disease Virus V Protein Is a Determinant of Host Range Restriction." Journal of Virology 77, no. 17 (2003): 9522–32. http://dx.doi.org/10.1128/jvi.77.17.9522-9532.2003.

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ABSTRACT It has been demonstrated that the V protein of Newcastle disease virus (NDV) functions as an alpha/beta interferon (IFN-α/β) antagonist (M. S. Park, M. L. Shaw, J. Muñoz-Jordan, J. F. Cros, T. Nakaya, N. Bouvier, P. Palese, A. García-Sastre, and C. F. Basler, J. Virol. 77:1501-1511, 2003). We now show that the NDV V protein plays an important role in host range restriction. In order to study V functions in vivo, recombinant NDV (rNDV) mutants, defective in the expression of the V protein, were generated. These rNDV mutants grow poorly in both embryonated chicken eggs and chicken emb
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19

Birge, R. B., J. E. Fajardo, C. Reichman, et al. "Identification and characterization of a high-affinity interaction between v-Crk and tyrosine-phosphorylated paxillin in CT10-transformed fibroblasts." Molecular and Cellular Biology 13, no. 8 (1993): 4648–56. http://dx.doi.org/10.1128/mcb.13.8.4648-4656.1993.

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The genome of avian sarcoma virus CT10 encodes a fusion protein in which viral Gag sequences are fused to cellular Crk sequences containing primarily Src homology 2 (SH2) and Src homology 3 (SH3) domains. Transformation of chicken embryo fibroblasts (CEF) with the Gag-Crk fusion protein results in the elevation of tyrosine phosphorylation on specific cellular proteins with molecular weights of 130,000, 110,000, and 70,000 (p130, p110, and p70, respectively), an event which has been correlated with cell transformation. In this study, we have identified the 70-kDa tyrosine-phosphorylated protein
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Birge, R. B., J. E. Fajardo, C. Reichman, et al. "Identification and characterization of a high-affinity interaction between v-Crk and tyrosine-phosphorylated paxillin in CT10-transformed fibroblasts." Molecular and Cellular Biology 13, no. 8 (1993): 4648–56. http://dx.doi.org/10.1128/mcb.13.8.4648.

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The genome of avian sarcoma virus CT10 encodes a fusion protein in which viral Gag sequences are fused to cellular Crk sequences containing primarily Src homology 2 (SH2) and Src homology 3 (SH3) domains. Transformation of chicken embryo fibroblasts (CEF) with the Gag-Crk fusion protein results in the elevation of tyrosine phosphorylation on specific cellular proteins with molecular weights of 130,000, 110,000, and 70,000 (p130, p110, and p70, respectively), an event which has been correlated with cell transformation. In this study, we have identified the 70-kDa tyrosine-phosphorylated protein
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21

Smith, Tameka, James S. Lewis, and Graeme N. Forrest. "1382. Acute Kidney Injury with Piperacillin–tazobactam and Vancomycin in the Intensive Care Unit." Open Forum Infectious Diseases 5, suppl_1 (2018): S423—S424. http://dx.doi.org/10.1093/ofid/ofy210.1213.

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Abstract Background Several recent retrospective studies have suggested that the combination of vancomycin (V) with piperacillin–tazobactam (PTZ) is associated with increased nephrotoxicity. We prospectively evaluated the outcomes of patients admitted to all of our medical and surgical intensive care units (ICU) with a normal baseline creatinine clearance (CrCl) that received vancomycin in combination with either cefepime (CEF) or PTZ to determine whether kidney injury occurs using RIFLE criteria. Methods ICU patients who received combinations of V with either PTZ or CEF were prospectively eva
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22

Levine, Mark N., Kathleen I. Pritchard, Vivien H. C. Bramwell, Lois E. Shepherd, Dongsheng Tu, and Nancy Paul. "Randomized Trial Comparing Cyclophosphamide, Epirubicin, and Fluorouracil With Cyclophosphamide, Methotrexate, and Fluorouracil in Premenopausal Women With Node-Positive Breast Cancer: Update of National Cancer Institute of Canada Clinical Trials Group Trial MA5." Journal of Clinical Oncology 23, no. 22 (2005): 5166–70. http://dx.doi.org/10.1200/jco.2005.09.423.

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Purpose Certain anthracycline-containing adjuvant chemotherapy regimens are associated with improved relapse-free survival (RFS) and overall survival (OS) compared with the classic regimen of cyclophosphamide, methotrexate, and fluorouracil in women with early-stage breast cancer. Patients and Methods Between 1989 and 1993, 710 pre- and perimenopausal women with axillary node–positive breast cancer were randomly assigned to either cyclophosphamide 75 mg/m2 orally days 1 through 14, epirubicin 60 mg/m2 intravenously days 1 and 8, and fluorouracil 500 mg/m2 intravenously days 1 and 8 (CEF) or CM
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23

Venkatachalam, T., and K. G. Lalitha. "DEVELOPMENT AND VALIDATION OF HPTLC METHOD FOR SIMULTANEOUS ESTIMATION OF CEFIXIME AND OFLOXACIN IN THEIR COMBINED TABLET DOSAGE FORM." INDIAN DRUGS 52, no. 06 (2015): 18–23. http://dx.doi.org/10.53879/id.52.06.10268.

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A simple, accurate and rapid high performance thin layer chromatography (HPTLC) -densitometry method was developed for separation and determination of cefixime (CEF) as an oral third generation cephalosporin antibiotic and ofloxacin (OFL) as a fluoroquinolone derivative used as antibacterial in pharmaceutical dosage forms. The compounds were separated on silica gel 60 GF254, HPTLC plates using a mixture of methanol: ethylacetate: ammonia solution (25%) (4:4.5:1.5 V/V/V) as the mobile phase. Compact spots of both cefixime (Rf=0.46±0.01) and ofloxacin (Rf=0.59±0.01) were obtained. A UV detection
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Kraus, Florian, and Sebastian A. Baer. "Tetraammine Tetrafluorido Cerium(IV) Ammonia (1/1), [CeF4(NH3)4] · NH3." Zeitschrift für Naturforschung B 66, no. 8 (2011): 868–70. http://dx.doi.org/10.1515/znb-2011-0815.

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The synthesis and crystal structure of the first ammine complex of a cerium fluoride, tetraammine tetrafluorido cerium(IV) ammonia (1/1), [CeF4(NH3)4] ・NH3, are presented. The compound crystallizes in the form of colorless, block-shaped single crystals in the tetragonal space group P4/ncc with a = 9.03215(9), c = 10.96404(17) Å , V = 894.443(19) Å3, and Z = 4. The compound contains discrete [CeF4(NH3)4] molecules interconnected by N-H···F hydrogen bonds.
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25

Tian, M., and G. S. Martin. "The role of the Src homology domains in morphological transformation by v-src." Molecular Biology of the Cell 8, no. 7 (1997): 1183–93. http://dx.doi.org/10.1091/mbc.8.7.1183.

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The Src homology (SH2 and SH3) domains of v-Src are required for transformation of Rat-2 cells and for wild-type (morphr) transformation of chicken embryo fibroblasts (CEFs). We report herein that the N-terminal domains of v-Src, when expressed in trans, cannot complement the transformation defect of a deletion mutant lacking the "unique," SH3, and SH2 regions. However, the same regions of Src can promote transformation when translocated to the C terminus of v-Src, although the transformation of CEFs is somewhat slower. We conclude that the SH3 and SH2 domains must be present in cis to the cat
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Susanto, Mutiara Putri Utami. "Pengaruh Taut Silang Natrium Tripolifosfat Dengan Kitosan Terhadap Sifat Fisis Chitosan Edible Film Sebagai Drug Delivery System." Sainteks: Jurnal Sains dan Teknik 1, no. 2 (2019): 99–103. http://dx.doi.org/10.37577/sainteks.v1i2.131.

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Limbah udang yang diekstraksi berupa kitosan bisa digunakan untuk pembuatan edible film. Chitosan Edible film (CEF) berpotensi digunakan sebagai media untuk drug delivery system. Sebagai contoh obat antibiotik digunakan asam salisilat. Untuk mengendalikan karakteristik edible film dan laju pelepasan obat (drug release), proses taut silang (crosslinking) perlu ditambahkan dalam pembuatan edible film dari kitosan dengan NaTPP sebagai crosslinker. Penelitian ini bertujuan untuk mempelajari pengaruh crosslinker NaTPP terhadap sifat fisik CEF. Tahapan percobaan pada penelitian ini adalah: (1) pembu
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Scholz, G., C. Martinerie, B. Perbal, and H. Hanafusa. "Transcriptional down regulation of the nov proto-oncogene in fibroblasts transformed by p60v-src." Molecular and Cellular Biology 16, no. 2 (1996): 481–86. http://dx.doi.org/10.1128/mcb.16.2.481.

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We have sought to identify genes whose expression is altered as a consequence of transformation by p60v-src. Using the mRNA differential display method, we have identified the nov proto-oncogene as one gene that is down regulated in chicken embryo fibroblasts (CEFs) transformed by p60v-src. nov transcripts were also found to be present at only very low levels in proliferating CEFs in comparison with quiescent CEFs. Serum stimulation of quiescent CEFs also resulted in a decline in the steady-state level of nov transcripts. Taken together, these findings suggest that the nov gene is expressed on
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Piu, Fabrice, та Marc Castellazzi. "Virally-expressed, nuclear oncogenes including v-jun/v-ios and v-myb, but not v-erbA, reverse TGF-β induced growth inhibition in CEFs". Biology of the Cell 76, № 2 (1992): 225. http://dx.doi.org/10.1016/0248-4900(92)90273-4.

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Park, Man-Seong, Megan L. Shaw, Jorge Muñoz-Jordan, et al. "Newcastle Disease Virus (NDV)-Based Assay Demonstrates Interferon-Antagonist Activity for the NDV V Protein and the Nipah Virus V, W, and C Proteins." Journal of Virology 77, no. 2 (2003): 1501–11. http://dx.doi.org/10.1128/jvi.77.2.1501-1511.2003.

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ABSTRACT We have generated a recombinant Newcastle disease virus (NDV) that expresses the green fluorescence protein (GFP) in infected chicken embryo fibroblasts (CEFs). This virus is interferon (IFN) sensitive, and pretreatment of cells with chicken alpha/beta IFN (IFN-α/β) completely blocks viral GFP expression. Prior transfection of plasmid DNA induces an IFN response in CEFs and blocks NDV-GFP replication. However, transfection of known inhibitors of the IFN-α/β system, including the influenza A virus NS1 protein and the Ebola virus VP35 protein, restores NDV-GFP replication. We therefore
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30

Penuel, Elicia, and G. Steven Martin. "Transformation by v-Src: Ras-MAPK and PI3K-mTOR Mediate Parallel Pathways." Molecular Biology of the Cell 10, no. 6 (1999): 1693–703. http://dx.doi.org/10.1091/mbc.10.6.1693.

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An increase in the level of active, GTP-bound Ras is not necessary for transformation of chicken embryo fibroblasts (CEF) by v-Src. This suggests that other Ras-independent pathways contribute to transformation by v-Src. To address the possibility that activation of phosphatidylinositol-3-kinase (PI3K) and the mammalian target of rapamycin (mTOR/FRAP), represents one of these pathways, we have examined the effect of simultaneous inhibition of the Ras-MAPK and PI3K-mTOR pathways on transformation of CEF by v-Src. Transformation was assessed by the standard parameters of morphological alteration
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31

Mosialos, G., P. Hamer, A. J. Capobianco, R. A. Laursen, and T. D. Gilmore. "A protein kinase-A recognition sequence is structurally linked to transformation by p59v-rel and cytoplasmic retention of p68c-rel." Molecular and Cellular Biology 11, no. 12 (1991): 5867–77. http://dx.doi.org/10.1128/mcb.11.12.5867-5877.1991.

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The Rel family of proteins includes a number of proteins involved in transcriptional control, such as the retroviral oncoprotein v-Rel, c-Rel, the Drosophila melanogaster developmental protein Dorsal, and subunits of the transcription factor NF-kappa B. These proteins are related through a highly conserved domain of approximately 300 amino acids, called the Rel homology domain, that contains dimerization, DNA binding, and nuclear targeting functions. Also within the Rel homology domain, there is a conserved consensus sequence (Arg-Arg-Pro-Ser) for phosphorylation by cyclic AMP-dependent protei
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32

Mosialos, G., P. Hamer, A. J. Capobianco, R. A. Laursen, and T. D. Gilmore. "A protein kinase-A recognition sequence is structurally linked to transformation by p59v-rel and cytoplasmic retention of p68c-rel." Molecular and Cellular Biology 11, no. 12 (1991): 5867–77. http://dx.doi.org/10.1128/mcb.11.12.5867.

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The Rel family of proteins includes a number of proteins involved in transcriptional control, such as the retroviral oncoprotein v-Rel, c-Rel, the Drosophila melanogaster developmental protein Dorsal, and subunits of the transcription factor NF-kappa B. These proteins are related through a highly conserved domain of approximately 300 amino acids, called the Rel homology domain, that contains dimerization, DNA binding, and nuclear targeting functions. Also within the Rel homology domain, there is a conserved consensus sequence (Arg-Arg-Pro-Ser) for phosphorylation by cyclic AMP-dependent protei
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33

Tareef, Tareq, William Groom, Elizabeth Moulder, et al. "PATIENT-REPORTED OUTCOME MEASURES (PROMS) AND INCIDENCE OF SECONDARY TOTAL KNEE ARTHROPLASTY (TKA) IN SCHATZKER GRADE V AND VI TIBIAL PLATEAU FRACTURES MANAGED BY CIRCULAR EXTERNAL FIXATION (CEF): A 15-YEAR SINGLE-CENTRE EXPERIENCE." Orthopaedic Proceedings 106-B, SUPP_5 (2024): 23. http://dx.doi.org/10.1302/1358-992x.2024.5.023.

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IntroductionSchatzker V & VI tibial plateau fractures are serious life-changing injuries often resulting in significant complications including post-traumatic arthritis. Reported incidence of secondary TKA following ORIF of all tibial plateau fractures is 7.3% and 13% for Schatzker V & VI tibial. This study reports a 15-year single centre experience of CEF of Schatzker V & VI fractures including PROMs and incidence of secondary TKA. This study was approved by the local Institutional board.Materials & MethodsAll patients from 2007 – 2022 with Schatzker V or VI fractures treated
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34

Akagi, Tsuyoshi, Kazutaka Murata, Tomoyuki Shishido, and Hidesaburo Hanafusa. "v-Crk Activates the Phosphoinositide 3-Kinase/AKT Pathway by Utilizing Focal Adhesion Kinase and H-Ras." Molecular and Cellular Biology 22, no. 20 (2002): 7015–23. http://dx.doi.org/10.1128/mcb.22.20.7015-7023.2002.

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ABSTRACT v-Crk, an oncogene product of avian sarcoma virus CT10, efficiently transforms chicken embryo fibroblasts (CEF). We have recently reported that constitutive activation of the phosphoinositide 3-kinase (PI3K)/AKT pathway plays a critical role in the v-Crk-induced transformation of CEF. In the present study we investigated the molecular mechanism by which v-Crk activates the PI3K/AKT pathway. First, we found that v-Crk promotes the association of the p85 regulatory subunit of PI3K with focal adhesion kinase (FAK) by inducing the phosphorylation of the Y397 residue in FAK. This FAK phosp
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35

Le Gac, Julie. "Le corps expéditionnaire français et l’armée américaine en Italie (1943-1944) : une alliance asymétrique." Revue Historique des Armées 258, no. 1 (2010): 57–66. http://dx.doi.org/10.3917/rha.258.0057.

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Le remplacement du terme de « 1 re armée » par celui de « corps expéditionnaire français » (CEF) pour désigner les unités françaises combattant en Italie illustre, par son caractère politique, l’emprise de l’armée américaine sur l’armée française. Réarmé et instruit par les États-Unis, le corps expéditionnaire français demeure tout au long de la campagne dépendant matériellement de l’armée américaine, en raison, en particulier de l’insuffisance de ses services. Certes, les victoires militaires remportées sur le terrain et la fermeté du Comité français de libération nationale (CFLN) extirpent l
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Datta, Anirban, Qi Shi та David E. Boettiger. "Transformation of Chicken Embryo Fibroblasts by v-src Uncouples β1 Integrin-Mediated Outside-in but Not Inside-out Signaling". Molecular and Cellular Biology 21, № 21 (2001): 7295–306. http://dx.doi.org/10.1128/mcb.21.21.7295-7306.2001.

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ABSTRACT Adhesion of cells to extracellular matrix is mediated by integrin family receptors. The process of receptor-ligand binding is dependent on metabolic energy and is regulated by intracellular signals, termed inside-out signals. The strength of the initial α5β1-mediated adhesion of v-src-transformed chicken embryo fibroblasts (v-srcCEF) was similar to that of normal CEF. A chemically cross-linked fibronectin substrate was able to restore cell spreading and the ability of v-srcCEF to assemble a fibronectin matrix. Over time, v-srcCEF showed decreased adhesion due to the reduction of α5β1-
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37

GUENDELMAN, E. I. "SCALE INVARIANCE, NEW INFLATION AND DECAYING Λ-TERMS". Modern Physics Letters A 14, № 16 (1999): 1043–52. http://dx.doi.org/10.1142/s0217732399001103.

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Realizations of scale invariance are studied in the context of a gravitational theory where the action (in the first-order formalism) is of the form [Formula: see text] where Φ is a density built out of degrees of freedom, the "measure fields" independent of gμν and matter fields appearing in L1, L2. If L1 contains the curvature, scalar potential V(ϕ) and kinetic term for ϕ, L2 another potential for ϕ, U(ϕ), then the true vacuum state has zero energy density, when theory is analyzed in the conformal Einstein frame (CEF), where the equations assume the Einstein form. Global scale invariance is
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38

Liu, Tao, Yuan Wang, Rongyao Ma, et al. "Simulation Studies on Single-Event Effects and the Mechanisms of SiC VDMOS from a Structural Perspective." Micromachines 14, no. 5 (2023): 1074. http://dx.doi.org/10.3390/mi14051074.

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The single-event effect reliability issue is one of the most critical concerns in the context of space applications for SiC VDMOS. In this paper, the SEE characteristics and mechanisms of the proposed deep trench gate superjunction (DTSJ), conventional trench gate superjunction (CTSJ), conventional trench gate (CT), and conventional planar gate (CT) SiC VDMOS are comprehensively analyzed and simulated. Extensive simulations demonstrate the maximum SET current peaks of DTSJ−, CTSJ−, CT−, and CP SiC VDMOS, which are 188 mA, 218 mA, 242 mA, and 255 mA, with a bias voltage VDS of 300 V and LET = 1
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39

Bell, S. M., D. C. Connolly, N. J. Maihle, and J. L. Degen. "Differential modulation of plasminogen activator gene expression by oncogene-encoded protein tyrosine kinases." Molecular and Cellular Biology 13, no. 9 (1993): 5888–97. http://dx.doi.org/10.1128/mcb.13.9.5888-5897.1993.

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Urokinase-type plasminogen activator (uPA) gene transcription is increased > or = 50-fold in chicken embryo fibroblasts (CEF) following transformation by the protein tyrosine kinase pp60v-src. Protein phosphorylation appears to play a critical role in uPA gene expression in these cells; protein kinase C-activating phorbol esters cooperate with pp60v-src to synergistically increase uPA mRNA, whereas cyclic AMP (cAMP)-dependent protein kinase-activating agents (e.g., 8-bromo cAMP) repress uPA mRNA levels. To explore the relationship between transforming oncogenes and uPA gene expression, uPA
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40

Bell, S. M., D. C. Connolly, N. J. Maihle, and J. L. Degen. "Differential modulation of plasminogen activator gene expression by oncogene-encoded protein tyrosine kinases." Molecular and Cellular Biology 13, no. 9 (1993): 5888–97. http://dx.doi.org/10.1128/mcb.13.9.5888.

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Urokinase-type plasminogen activator (uPA) gene transcription is increased > or = 50-fold in chicken embryo fibroblasts (CEF) following transformation by the protein tyrosine kinase pp60v-src. Protein phosphorylation appears to play a critical role in uPA gene expression in these cells; protein kinase C-activating phorbol esters cooperate with pp60v-src to synergistically increase uPA mRNA, whereas cyclic AMP (cAMP)-dependent protein kinase-activating agents (e.g., 8-bromo cAMP) repress uPA mRNA levels. To explore the relationship between transforming oncogenes and uPA gene expression, uPA
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41

Diehl, J. A., T. A. McKinsey, and M. Hannink. "Differential pp40I kappa B-beta inhibition of DNA binding by rel proteins." Molecular and Cellular Biology 13, no. 3 (1993): 1769–78. http://dx.doi.org/10.1128/mcb.13.3.1769-1778.1993.

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Regulation of gene expression by members of the NF-kappa B/rel transcription factor family is a central component of signal transduction pathways utilized by many cellular processes, including lymphocyte activation, embryonic development, and oncogenesis. The members of the NF-kappa B/rel transcription factor family are regulated by association with a family of inhibitor (I kappa B) proteins (I kappa B) proteins. To address the importance of the association between rel and I kappa B proteins for oncogenesis by rel proteins, we characterized rel-I kappa B interactions in chicken embryo fibrobla
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42

Diehl, J. A., T. A. McKinsey, and M. Hannink. "Differential pp40I kappa B-beta inhibition of DNA binding by rel proteins." Molecular and Cellular Biology 13, no. 3 (1993): 1769–78. http://dx.doi.org/10.1128/mcb.13.3.1769.

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Regulation of gene expression by members of the NF-kappa B/rel transcription factor family is a central component of signal transduction pathways utilized by many cellular processes, including lymphocyte activation, embryonic development, and oncogenesis. The members of the NF-kappa B/rel transcription factor family are regulated by association with a family of inhibitor (I kappa B) proteins (I kappa B) proteins. To address the importance of the association between rel and I kappa B proteins for oncogenesis by rel proteins, we characterized rel-I kappa B interactions in chicken embryo fibrobla
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43

Joensuu, H., K. Holli, M. Heikkinen, et al. "Combination chemotherapy versus single-agent therapy as first- and second-line treatment in metastatic breast cancer: a prospective randomized trial." Journal of Clinical Oncology 16, no. 12 (1998): 3720–30. http://dx.doi.org/10.1200/jco.1998.16.12.3720.

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PURPOSE We report results of a randomized prospective study that compared single agents of low toxicity given both as the first-line and second-line chemotherapy with combination chemotherapy in advanced breast cancer with distant metastases. PATIENTS AND METHODS Patients in the single-agent arm (n = 153) received weekly epirubicin (E) 20 mg/m2 until progression or until the cumulative dose of 1,000 mg/m2, followed by mitomycin (M) 8 mg/m2 every 4 weeks, and those in the combination chemotherapy arm (n = 150) were first given cyclophosphamide 500 mg/m2, E 60 mg/m2, and fluorouracil 500 mg/m2 t
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44

KOTANI, A. "CORE-HOLE EFFECT IN THE Ce L3 X-RAY ABSORPTION SPECTRA OF CeO2 AND CeFe2: NEW EXAMINATION BY USING RESONANT X-RAY EMISSION SPECTROSCOPY." Modern Physics Letters B 27, no. 16 (2013): 1330012. http://dx.doi.org/10.1142/s0217984913300123.

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We consider two different resonant X-ray emission spectra for Ce compounds: Ce 3d to 2p X-ray emission (denoted by 3d-RXES) and valence to 2p X-ray emission (v-RXES), both of which follow the Ce 2p to 5d resonant excitation. We propose that the comparison of the 3d- and v-RXES spectra is a new powerful method of directly detecting the core-hole effect in the final state of Ce L 3 X-ray absorption spectra (XAS). We applied this method to recent experimental RXES spectra for CeO 2 and CeFe 2, and showed unambiguously that the core-hole effect should be essential in the XAS of both materials. Thi
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45

Sapino, Simona, Elena Peira, Daniela Chirio, et al. "Thermosensitive Nanocomposite Hydrogels for Intravitreal Delivery of Cefuroxime." Nanomaterials 9, no. 10 (2019): 1461. http://dx.doi.org/10.3390/nano9101461.

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Endophthalmitis is a rare, but serious, intravitreal inflammatory disorder that can arise after cataract surgery. The intracameral injection of 1 mg cefuroxime (CEF) followed by three-times daily antibiotic topical administration for a week is generally recognized as the routine method of prophylaxis after cataract surgery. This procedure is controversial because of both the low efficacy and the low adherence to therapy by elderly patients. A unique slow release antibiotic intravitreal injection could solve these problems. The objective of the present study was to design ophthalmic nanocomposi
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46

Wang, Hui, Xiao-Qian Wang, Yi-Zhang Xing, Qing-Yun Zhao, Hui-Fa Zhuang, and Wei Huang. "Regulation of Chloroplast ATP Synthase Modulates Photoprotection in the CAM Plant Vanilla planifolia." Cells 11, no. 10 (2022): 1647. http://dx.doi.org/10.3390/cells11101647.

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Generally, regulation of cyclic electron flow (CEF) and chloroplast ATP synthase play key roles in photoprotection for photosystems I and II (PSI and PSII) in C3 and C4 plants, especially when CO2 assimilation is restricted. However, how CAM plants protect PSI and PSII when CO2 assimilation is restricted is largely known. In the present study, we measured PSI, PSII, and electrochromic shift signals in the CAM plant Vanilla planifolia. The quantum yields of PSI and PSII photochemistry largely decreased in the afternoon compared to in the morning, indicating that CO2 assimilation was strongly re
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Qian, Yong, Linda Corum, Qiao Meng, et al. "PI3K induced actin filament remodeling through Akt and p70S6K1: implication of essential role in cell migration." American Journal of Physiology-Cell Physiology 286, no. 1 (2004): C153—C163. http://dx.doi.org/10.1152/ajpcell.00142.2003.

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This study was designed to identify the molecular mechanisms of phosphatidylinositol 3-kinase (PI3K)-induced actin filament remodeling and cell migration. Expression of active forms of PI3K, v-P3k or Myr-P3k, was sufficient to induce actin filament remodeling to lead to an increase in cell migration, as well as the activation of Akt in chicken embryo fibroblast (CEF) cells. Either the inhibition of PI3K activity using a PI3K-specific inhibitor, LY-294002, or the disruption of Akt activity restored the integrity of actin filaments in CEF cells and inhibited PI3K-induced cell migration. We also
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48

J, Romano Morris, Lazar M, and Henry J. "A-160 Understanding the Validity of the Digit Span Sequencing Task: A Least Executive Demand Model." Archives of Clinical Neuropsychology 35, no. 6 (2020): 954. http://dx.doi.org/10.1093/arclin/acaa068.160.

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Abstract Objective This study aimed to explore the patterns of Longest Digit Span from the Wechsler Intelligence Scale for Children, Fifth Edition (WISC-V), including understanding the newest sequencing condition. While there is a large body of research discriminating the cognitive demands of the forward and backward conditions, there is less literature devoted to the cognitive underpinnings of the sequencing task, and no studies looking at the applicability of this task with children. Patterns observed clinically on these conditions have suggested that the sequencing condition may involve les
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49

Mariana, Vieira Santana, Jovina Barreto Bispo Ana, and Vieira Santana Felipe. "EVOLUÇÃO ANTROPOMÉTRICA DO NASCIMENTO AOS QUATRO ANOS DE PACIENTES COM SÍNDROME CONGÊNITA PELO ZIKA VÍRUS: UM ESTUDO DE COORTE." Revistaft 27, no. 126 (2023): 72. https://doi.org/10.5281/zenodo.8331572.

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Introdução: A Síndrome Congênita do Zika Vírus é caracterizada por um conjunto de manifestações em neonatos que foram expostos a esse vírus durante a gestação. Em 2016, essa síndrome foi declarada uma Emergência de Saúde Pública de Interesse Internacional. Desse modo, foi desenhado esse estudo com o objetivo de avaliar a evolução antropométrica das crianças acometidas pela SCZ desde o nascimento até os 4 anos de idade e conhecer a classificação
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50

Del Mastro, Lucia, Marco Venturini, Rita Lionetto, et al. "Accelerated-Intensified Cyclophosphamide, Epirubicin, and Fluorouracil (CEF) Compared With Standard CEF in Metastatic Breast Cancer Patients: Results of a Multicenter, Randomized Phase III Study of the Italian Gruppo Oncologico Nord-Ouest–Mammella Inter Gruppo Group." Journal of Clinical Oncology 19, no. 8 (2001): 2213–21. http://dx.doi.org/10.1200/jco.2001.19.8.2213.

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PURPOSE: To evaluate whether an accelerated-intensified cyclophosphamide, epirubicin, and fluorouracil (CEF) chemotherapy regimen with the support of granulocyte colony-stimulating factor (G-CSF) induces a higher activity and efficacy compared with standard CEF in metastatic breast cancer patients. PATIENTS AND METHODS: Stage IV breast cancer patients were randomized to receive as first-line chemotherapy either standard CEF (cyclophosphamide 600 mg/m2, epirubicin 60 mg/m2, and fluorouracil 600 mg/m2) administered every 21 days (CEF21) or accelerated-intensified CEF (cyclophosphamide 1,000 mg/m
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