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Rozprawy doktorskie na temat „Cell differentiation”

Autor: Grafiati

Data publikacji: 4 czerwca 2021

Data aktualizacji: 25 lipca 2025

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1

Falk, Anna. "Stem cells : proliferation, differentiation, migration /." Stockholm, 2005. http://diss.kib.ki.se/2006/91-7140-497-X/.

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2

Brigham, Lindy Andersen 1951. "Root border cell differentiation." Diss., The University of Arizona, 1996. http://hdl.handle.net/10150/290689.

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The inability of a plant to run from danger or seek nutrients necessitates its capacity to change the environment of the surrounding soil for protection and sustenance. A unique plant process, the release of thousands of autonomous cells from the root cap, called root border cells, may play a role in the ability of the plant to regulate microbial populations and nutrient availability in the rhizosphere. In this study, evidence is presented showing that root border cells are a differentiated tissue, that the production of border cells is highly regulated and tied to cell turnover in the root ca

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3

Loop, Franciscus Theodorus Lambertus van der. "Cell biological aspects of muscle cell differentiation." Maastricht : Maastricht : Universitaire Pers Maastricht ; University Library, Maastricht University [Host], 1996. http://arno.unimaas.nl/show.cgi?fid=7288.

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4

Li, Victor Chun. "The Cell Cycle and Differentiation in Stem Cells." Thesis, Harvard University, 2012. http://dissertations.umi.com/gsas.harvard:10536.

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The relationship between cellular proliferation and differentiation is a major topic in cell biology. What we know comes from models of somatic cell differentiation, where it is widely viewed that cycling and differentiation are coupled, antagonistic phenomena linked at the G1 phase. The extension of this view to stem cells, however, is unclear. One potential possibility is that stem cells also tightly link their G1 phase with their differentiation, indicating a similarity between the differentiation of stem cells and the differentiation of more mature somatic cells. On the other hand, stem ce

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5

Ellison, David William. "Cell proliferation, cell death, and differentiation in gliomas." Thesis, University of Southampton, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.295912.

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6

Xue, Yintong. "Glucocorticoid in T cell differentiation /." Stockholm, 1999. http://diss.kib.ki.se/1999/91-628-3950-0/.

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7

Locklin, Rachel M. S. "Biochemistry of bone cell differentiation." Thesis, University of Oxford, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.363755.

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8

Giddings, Ian. "Analysis of myeloid cell differentiation." Thesis, King's College London (University of London), 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.285145.

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9

Jones, Philip Anthony. "B cell differentiation in sheep." Thesis, University of Edinburgh, 1988. http://hdl.handle.net/1842/30327.

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The ileal Peyer's patch (IPP) of lambs is a region of intense lymphopoiesis and B cell development. Monoclonal antibodies against ovine lymphoctye antigens have been used to characterise the IPP lymphocyte. Three murine monoclonal antibodies against ovine IgM, IgG1 and Ig light chain were produced and are described fully. IgM and MHC class II antigens are expressed on the vast majority of IPP cells whilst cells bearing other serum Ig isotypes and T cell antigens are rare. A novel Ig molecule appears to be coexpressed with IgM, it is proposed that this is the ovine equivalent of IgD. IPP cells

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10

Park, Jaesang. "Automatic white blood cell differentiation /." free to MU campus, to others for purchase, 2002. http://wwwlib.umi.com/cr/mo/fullcit?p3074435.

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11

Holm, Pontus. "Survival and differentiation of central noradrenergic neurons /." Stockholm, 2002. http://diss.kib.ki.se/2002/91-7349-277-9.

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12

Sankar, Uma. "Coordination of cell cycle and cell differentiation by receptor activator of NF-KAPA-B ligand during osteoclast differentiation." Columbus, Ohio : Ohio State University, 2003. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1056980709.

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Thesis (Ph. D.)--Ohio State University, 2003.<br>Title from first page of PDF file. Document formatted into pages; contains xvii, 292 p.; also includes graphics (some col.). Includes abstract and vita. Advisor: Mihael C. Ostrowski, Dept. of Molecular, Cellular and Developmental Biology. Includes bibliographical references (p. 259-292).

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13

Erlandsson, Anna. "Neural Stem Cell Differentiation and Migration." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl.[distributör], 2003. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3546.

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14

Ansari, Naser A. (Naser Awni). "Purification and Characterization of a Differentiation Factor From Rat Lung Conditioned Medium." Thesis, North Texas State University, 1988. https://digital.library.unt.edu/ark:/67531/metadc798062/.

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A Differentiation Factor (DF) was purified from rat lung conditioned medium by a four-steps procedure. The DF has a molecular weight of 27000, and an isoelectric point of 4.70. Although DF is stable up to 60°C, it is sensitive to digestion by trypsin, chymotrypsin and subtilisin. DF forms granulocyte colonies in soft agar. Studies using anti-NRK CSF antibody demonstrated that DF is distinct from GM-CSF.

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15

Muguruma, Yukari. "The origin and differentiation of the osteoclast /." Thesis, Connect to this title online; UW restricted, 1998. http://hdl.handle.net/1773/5681.

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16

Liu, Haoyu. "Goblet cell differentiation in human colorectal cancer cell lines." Thesis, University of Oxford, 2017. https://ora.ox.ac.uk/objects/uuid:d907bbf2-76fc-409a-877c-529fc04ca042.

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Goblet cells are one of the three fully differentiated lineages in human colonic crypts. They play an important role in protecting epithelial cells from direct contact with luminal contents by secreting mucus, which consists of MUC2, TFF3 and other constituents. The goblet cell differentiation, however, is largely dysregulated in human colorectal cancers. Abundant expression of MUC2 is often observed in signet ring carcinomas and mucinous carcinomas that are associated with unsatisfactory prognosis. Despite the significant roles of goblet cells, its genetic nature and exact regulatory mechanis

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17

Lu, Xibin, and 盧希彬. "Quantitative characterization of mouse embryonic stem cell state transition." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2014. http://hdl.handle.net/10722/208049.

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18

Lyons, Alan Bruce. "Human myeloid differentiation antigens /." Title page, table of contents and abstract only, 1987. http://web4.library.adelaide.edu.au/theses/09PH/09phl991.pdf.

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19

Rennel, Emma. "Molecular Mechanisms in Endothelial Cell Differentiation." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4059.

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20

Graaff, Wiebo Leendert van der. "T cell differentiation in autoimmune diseases." [S.l. : Amsterdam : s.n.] ; Universiteit van Amsterdam [Host], 2003. http://dare.uva.nl/document/70775.

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21

Masciarelli, Silvia. "Molecular physiology of plasma cell differentiation." Thesis, Open University, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.491475.

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Plasma cells are central to an effective immune response, being the sole producers of the antibodies, yet they can caqse severe disease in autoimmunity and multiple myeloma. Therefore their differentiation and survival must be tightly regulated. In this work I investigated some of the mechanisms regulating plasma cell differentiation and life span. The differentiation of a long lived B cell to a short lived plasma cell entails a profound structural and functional metamorphosis finalized to the massive production of immunoglobulins (Ig). Exuberant Ig synthesis causes several types of stress in

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22

Jermyn, Keith A. "Prestalk cell differentiation in Dictyostelium discoideum." Thesis, Open University, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.314869.

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23

Marek, Carylyn Jane. "Trans-differentiation and liver cell biology." Thesis, University of Aberdeen, 2004. http://digitool.abdn.ac.uk/R?func=search-advanced-go&find_code1=WSN&request1=AAIU186421.

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Trans-differentiation is the term applied where one fully differentiated cell type changes into another fully differentiated cell type. The AR432J-B13 cell line has been shown to demonstrate this phenomenon in vitro. These cells of exocrine pancreatic lineage, can trans-differentiate into hepatocytes upon treatment with the synthetic glucocorticoid dexamethasone. This thesis demonstrates that the generation of these cells (B13-H) from AR42J-B13 cells could prove to be a novel source of hepatocytes in culture. B13-H cells express functionally active and inducible CYP enzymes for at least 30 day

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24

Shah, Nadia Nisa. "Human embryonic stem cells : prospects for pancreatic β-cell differentiation". Thesis, University of Manchester, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.495052.

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The focus of this thesis was to explore different strategies in trying to generate putative pancreatic β-cells using one of the initial Wisconsin H7 hES cell lines. Prior to this, human pancreas development was assessed during the first trimester of pregnancy in an attempt to determine the spatial and temporal expression of development and mature pancreatic β-cell markers during this period. Spontaneous differentiation of hES cells can be induced by the formation of embryoid bodies (EBs) in suspension culture. EBs began to express markers of pancreatic β-cell development and function at a mole

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25

VanOudenhove, Jennifer J. "Mechanisms Regulating Early Mesendodermal Differentiation of Human Embryonic Stem Cells: A Dissertation." eScholarship@UMMS, 2016. http://escholarship.umassmed.edu/gsbs_diss/849.

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Key regulatory events take place at very early stages of human embryonic stem cell (hESC) differentiation to accommodate their ability to differentiate into different lineages; this work examines two separate regulatory events. To investigate precise mechanisms that link alterations in the cell cycle and early differentiation, we examined the initial stages of mesendodermal lineage commitment and observed a cell cycle pause that occurred concurrently with an increase in genes that regulate the G2/M transition, including WEE1. Inhibition of WEE1 prevented the G2 pause. Directed differentiation

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26

Bennett, Jonathan Hilary. "The differentiation of osteogenic cells from bone marrow." Thesis, University of Oxford, 1991. http://ora.ox.ac.uk/objects/uuid:3460f26e-a124-4605-8601-2e300241de14.

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27

Beckstead, Benjamin L. "Control of epithelial differentiation by cell-instructive scaffolds /." Thesis, Connect to this title online; UW restricted, 2006. http://hdl.handle.net/1773/8096.

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28

Ortmann, Daniel. "Reporter cell lines to study cell populations and fate decisions during human pluripotent stem cell differentiation in vitro." Thesis, University of Cambridge, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.648356.

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29

Watson, Andrea. "Heat shock proteins in leukaemia cell differentiation and cell death." Thesis, Aston University, 1990. http://publications.aston.ac.uk/12533/.

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When HL60 cells were induced to differentiate to granulocyte-like cells with the agents N-methylformamide and tunicamycin an concentrations marginally below those which were cytotoxic, there was a decrease in the synthesis of the glucose- regulated proteins which preceded the expression of markers of a differentiated phenotype. There was a transient increase in the amount of hsp70 after 36 hours in NMF treated cells but in differentiated cells negligible amounts were detected. Inducers which were known to modulate hsp70 such as azetadine carboxylic acid did not induce differentiation suggestin

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30

Sancho, Maria Margarida Gouveia. "Function of Bmpr1a in ES cell differentiation and cell competition." Thesis, Imperial College London, 2009. http://hdl.handle.net/10044/1/5885.

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Bone morphogenetic protein (BMP) 4 signalling via BMPR1A is required for the maintenance of the epiblast in the early embryo, and for self-renewal of pluripotent mouse embryonic stem (ES) cells by inhibiting neural differentiation. In this study, the self-renewal and differentiation abilities of ES cells lacking BMPR1A were investigated. Bmpr1a-null ES cells did not respond to BMP4 but retained a degree of SMAD1/5/8 activation and Id1 expression. This activation was likely due to BMP7 signalling via ACVR1. The observation that Bmpr1a-/- ES cells showed no selfrenewal or pluripotency defects su

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31

Leung, Y. L., and 梁宇亮. "Transcriptional regulators of col10al in chondrocyte differentiation." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2003. http://hub.hku.hk/bib/B31244440.

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32

Li, Jing. "Effects of intrinsic & extrinsic factors on the growth and differentiation of human mesenchymal stem cells." View the Table of Contents & Abstract, 2006. http://sunzi.lib.hku.hk/hkuto/record/B36434450.

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33

Fan, Ngo-yin, and 樊傲賢. "The role of protein kinase D in osteoblast differentiation." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2008. http://hub.hku.hk/bib/B41508488.

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34

Apperly, James A. "The relationship between proliferation and differentiation during oligodendrocyte development." Thesis, University College London (University of London), 2001. http://discovery.ucl.ac.uk/1349376/.

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How do precursor cells know when it is time to stop dividing and differentiate? The phenomenon of lineage-specific progenitor cells undergoing a limited period of proliferation prior to terminal differentiation is a common theme in multicellular development. Despite this, little is understood about how these two events are co-ordinated during the normal schedule of development. I have studied the question of how proliferation and differentiation are co-regulated in the oligodendrocyte lineage in the rodent optic nerve. Oligodendrocytes are post-mitotic cells that myelinate axons in the vertebr

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35

Fan, Ngo-yin. "The role of protein kinase D in osteoblast differentiation." Click to view the E-thesis via HKUTO, 2008. http://sunzi.lib.hku.hk/hkuto/record/B41508488.

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36

Constant, Vanessa Auguste. "Macrophage-conditioned medium inhibits adipocyte differentiation." Thesis, University of Ottawa (Canada), 2008. http://hdl.handle.net/10393/27967.

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Obesity is accompanied by a reduced adipogenic capacity that promotes a dipocyte hypertrophy, low-grade inflammation, and insulin resistance. Macrophages infiltrate adipose tissue and may contribute to the low-grade inflammation associated with obesity and insulin resistance, suggesting that they could also play an anti-adipogenic role. I hypothesized that macrophage-secreted factors inhibit adipogenesis. My objectives were to assess if macrophage-conditioned medium (MacCM) inhibits adipocyte differentiation and to determine the mechanism by which the inhibition occurs. Murine J774 or human TH

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37

Capra, J. (Janne). "Differentiation and malignant transformation of epithelial cells:3D cell culture models." Doctoral thesis, Oulun yliopisto, 2018. http://urn.fi/urn:isbn:9789526218236.

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Abstract The epithelial cells form barriers that compartmentalize the organs. Carcinomas are cancers stemming from epithelial cells and are the most common cancer type. The aim of this study was to understand the differentiation and malignant transformation of epithelial Madin-Darby canine kidney (MDCK) cells and to analyse the electrophysiological parameters which regulate their transport capacity. Emphasis was placed on comparing different culture environments, both in 2D and 3D. First, the effects of drugs or basal extracellular fluid composition on MDCK cell, cyst and lumen volumes were an

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38

Fong, Jenna. "Breast cancer cells affect bone cell differentiation and the bone microenvironment." Thesis, McGill University, 2011. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=104758.

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Breast carcinoma is the most commonly diagnosed cancer among women worldwide, with approximately 1 in 7 expected to be affected during her lifetime. The spread of breast cancer to secondary sites is generally incurable. Bone is the preferred site of metastasis, where the development of a secondary tumour causes severe osteolysis, hypercalcemia and a considerable pain burden. However, how breast cancer cells establish supportive interactions with bone cells is not well understood. We have examined the effects of factors released from MDA-MB-231 and 4T1 breast cancer cells on the differentiation

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39

Cowan, Gillian. "Fetal germ cell differentiation and the impact of the somatic cells." Thesis, University of Edinburgh, 2009. http://hdl.handle.net/1842/4164.

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Specification of a germ cell lineage and appropriate maturation are essential for the transfer of genetic information from one generation to the next. Germ cells form from pluripotent precursor cells that migrate into the gonadal ridge and undergo commitment to either the female or male lineage. In the fetal ovary, germ cells enter meiotic prophase I, then arrest at the diplotene stage; in the testis germ cells do not begin meiosis until puberty. Abnormal differentiation of germ cells can result in malignant transformation. Somatic cells play a key role in modulating the developmental fate of

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40

Yang, Liu, and 楊柳. "Genetic analyses of terminal differentiation of hypertrophic chondrocytes." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2009. http://hdl.handle.net/10722/210320.

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41

Yang, Liu. "Genetic analyses of terminal differentiation of hypertrophic chondrocytes." Click to view the E-thesis via HKUTO, 2009. http://sunzi.lib.hku.hk/hkuto/record/B43223758.

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42

Nsiah, Barbara Akua. "Fluid shear stress modulation of embryonic stem cell differentiation." Diss., Georgia Institute of Technology, 2012. http://hdl.handle.net/1853/47552.

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Vascularization of tissue-engineered substitutes is imperative for successful implantation into sites of injury. Strategies to promote vascularization within tissue-engineered constructs have focused on incorporating endothelial or endothelial progenitor cells within the construct. However, since endothelial and endothelial progenitor cells are adult cell types and limited in number, acquiring quantities needed for regenerative medicine applications is not feasible. Pluriopotent stem cells have been explored as a cell source for tissue-engineered substitutes because of their inherent abili

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43

Lemos, Sara Sofia de Campos Pereira. "CD8 T cell differentiation during immune responses." Thesis, Paris 5, 2014. http://www.theses.fr/2014PA05T009/document.

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Les lymphocytes T CD8 ont un rôle essentiel dans la protection contre les agents pathogènes intracellulaires et la progression tumorale. Ainsi, la compréhension de la diversité des mécanismes de différenciation des lymphocytes T CD8 naïfs en cellules effectrices, ainsi qu’en cellules mémoires compétentes, est fondamentale pour le développement efficace de vaccins à cellules T. Dans ce travail de thèse, nous avons abordé deux questions centrales : (1)Très tôt après l’activation des cellules T CD8, quels sont les mécanismes par lesquels les cellules T effectrices agissent comme effecteurs pro-in

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44

Syvertsson, Simon. "Bistable differentiation in an isogenic cell population." Thesis, University of Newcastle upon Tyne, 2015. http://hdl.handle.net/10443/3002.

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Single-cell organisms such as bacteria have traditionally been regarded as discrete units, which in turn has been reflected by the bulk-level methods used to study them. A growing culture of the bacterium Bacillus subtilis will exhibit a range of heterogeneous genetic developmental programmes such as motility, competence, and finally sporulation. As a popular choice for production of compounds in bioreactors, the bistable behaviours of B. subtilis may be undesirable traits, as they divert resources from their intended activity of synthesising a product. This thesis investigates a novel observa

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45

Rijal, Dikchha. "Cell Death Signaling Complexes During Macrophage Differentiation." Thesis, Université d'Ottawa / University of Ottawa, 2017. http://hdl.handle.net/10393/36455.

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Monocytes migrate to various tissues and differentiate to macrophages and mediate early control of pathogens. Various alternative pathways of cell death have been discovered which have been shown to play a key role in host survival. Herein, we investigated the impact of differentiation of monocytes to macrophages on their susceptibility to two distinct cell death inducing complexes, ripoptosome and necrosome. Our results indicate that differentiation of macrophages results in resistance to ripoptosome- but not necrosome- induced cell death. Additional experiments indicated that the resistance

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46

Gore, S. "Neuronal differentiation markers in basal cell carcinoma." Thesis, University College London (University of London), 2007. http://discovery.ucl.ac.uk/1445574/.

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Basal cell carcinoma (BCC) is the most common skin cancer in humans. The demonstration of genetic and protein alterations has, so far, had limited correlation with either biological behaviour or histological classification of these tumours. It was observed that Glil-overexpressing keratinocytes express elevated levels of genes known to be associated with neuronal development, including p-tubulin III, GAP-43, Arc and neurofilament. It was proposed that these genes may similarly be overexpressed in BCCs and that different levels of expression may be present in different BCC subtypes Immunohistoc

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47

Wurff, A. A. M. van der. "Cell differentiation and adhesion in colorectal cancer." [Maastricht : Maastricht : Universiteit Maastricht] ; University Library, Maastricht University [Host], 1998. http://arno.unimaas.nl/show.cgi?fid=8253.

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48

Henderson, Andrew Paul. "Small molecules for controlling stem cell differentiation." Thesis, Durham University, 2011. http://etheses.dur.ac.uk/3559/.

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Stem cell homeostasis and differentiation are controlled by the complex interplay of a wide range of signalling pathways and small molecules, including all-trans-retinoic acid (ATRA). The endogenous effects elicited by ATRA, have led to its use in numerous in vitro protocols as a tool for cell differentiation. However, ATRA isomerises and degrades under standard laboratory conditions and furthermore, is rapidly metabolised in vivo, which leads to pleotropic effects and a high efficacious dose response. Consequently, synthetic analogues that are structurally and/or functionally equivalent to AT

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49

De, Campos Pereira Lemos Sara Sofia. "CD8 T cell differentiation during immune responses." Phd thesis, Université René Descartes - Paris V, 2014. http://tel.archives-ouvertes.fr/tel-01059806.

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CD8 T cells are essential for the elimination of intracellular pathogens and tumor cells. Understanding how naïve CD8 T cells differentiate into effector cells capable of eliminating pathogens and to generate adequate memory cells during immune responses is fundamental for optimal T cell vaccine design. In this PhD thesis work we addressed two central questions: 1) What are the mechanisms by which early effector T cells could act as pro-inflammatory effectors? And what is their role in the immune response? 2) How heterogeneous are CD8 responses? Could different pathogens modulate CD8 T cell di

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50

Cardoso, Sandra Pinto. "Control of cell differentiation during secondary myogenesis." Thesis, University of Nottingham, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.250587.

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