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Artykuły w czasopismach na temat „Cell Mediated Immunity (CMI)”

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Data publikacji: 3 czerwca 2025

Data aktualizacji: 31 lipca 2025

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1

Otto, William R., Surabhi B. Vora, and Daniel E. Dulek. "Cytomegalovirus Cell-mediated Immunity Assays in Pediatric Transplantation." Journal of the Pediatric Infectious Diseases Society 13, Supplement_1 (2024): S22—S30. http://dx.doi.org/10.1093/jpids/piae005.

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Abstract Cytomegalovirus (CMV) is a significant cause of morbidity and mortality in pediatric transplantation. However, currently utilized CMV prevention paradigms have limitations, leading to research aimed at novel strategies for mitigation of CMV infection. Cell-mediated immunity (CMI) is crucial in controlling CMV infection and the use of CMV-specific CMI assays to guide prevention and treatment of CMV infection in both solid organ transplant and hematopoietic cell transplant recipients shows great promise. In this article, we review the immune response to CMV infection to highlight the ra

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van der Heyde, H. C., D. Huszar, C. Woodhouse, D. D. Manning, and W. P. Weidanz. "The resolution of acute malaria in a definitive model of B cell deficiency, the JHD mouse." Journal of Immunology 152, no. 9 (1994): 4557–62. http://dx.doi.org/10.4049/jimmunol.152.9.4557.

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Abstract Because the role of cell-mediated immunity (CMI) in the resolution of blood-stage malaria remains unclear, we examined the question of whether mice completely lacking Ab-mediated immunity (AMI) but possessing some CMI can resolve experimental malaria previously reported not to require AMI for resolution. Severe combined immunodeficient mice reconstituted with enriched immune T cells (&lt; 0.5% B220+ cells) suppressed acute Plasmodium chabaudi adami parasitemia, suggesting that T, but not B, cells are required to clear this form of malaria. In addition, JHD mice, which are a defini

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Nicolini, A., A. Pieraccini, C. Tibaldi, et al. "Cell mediated immunity (CMI) in non relapsed breast cancer patients." European Journal of Cancer and Clinical Oncology 27 (January 1991): S19. http://dx.doi.org/10.1016/0277-5379(91)91176-j.

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Nicolini, A., P. Ferrari, R. Spinelli, et al. "Cell mediated immunity (CMI) in non relapsed breast cancer patients." Biomedicine & Pharmacotherapy 47, no. 6-7 (1993): 291. http://dx.doi.org/10.1016/0753-3322(93)90239-h.

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Hegde, Nagendra R., and S. Srikumaran. "Reverse immunogenetic and polyepitopic approaches for the induction of cell-mediated immunity against bovine viral pathogens." Animal Health Research Reviews 1, no. 2 (2000): 103–18. http://dx.doi.org/10.1017/s1466252300000098.

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AbstractThe control of several infectious diseases of animals by vaccination is perhaps the most outstanding accomplishment of veterinary medicine in the last century. Even the eradication of some pathogens is in sight, at least in some parts of the world. However, infectious diseases continue to cost millions of dollars to the livestock industry. One of the reasons for the failure to control certain pathogens is the limited emphasis placed on cell-mediated immunity (CMI) in the design of vaccines against these pathogens. Traditionally, vaccine-induced immunity has been studied in relation to

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6

Harrison, Christopher J., and Martin G. Myers. "980 CYTOMEGALOVIRUS (CMV) SPECIFIC CYTOTOXIC CELL-MEDIATED IMMUNITY (CMI) DURING PREGNANCY." Pediatric Research 19, no. 4 (1985): 274A. http://dx.doi.org/10.1203/00006450-198504000-01010.

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Czarnecki, D., A. Mar, and E. Kulinskaya. "Cell-mediated immunity of patients who have had basal cell carcinomas." Acta Dermato-Venereologica 76, no. 1 (1996): 28–30. http://dx.doi.org/10.2340/00015555762830.

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The cell-mediated immunity of patients who had basal cell carcinomas (BCCs) removed was studied by measuring cuntaneous delayed hypersensitivity reactions to recall antigens (Multitest CMI, Pasteur-Merieux), and by measuring lymphocyte counts and subsets. One group of patients had multiple BCCs (3 or more) removed and were considered to have a high risk of new BCC formation. The other group consisted of patients who had one BCC and had not developed another within 5 years

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Abidi, Maheen, Jonathan Gutman, and Adriana Weinberg. "1102. Reconstitution of CMV-specific cell-mediated immunity during letermovir prophylaxis in hematopoietic stem cell recipients." Open Forum Infectious Diseases 7, Supplement_1 (2020): S581. http://dx.doi.org/10.1093/ofid/ofaa439.1288.

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Abstract Background Patients who are cytomegalovirus (CMV) seropositive (R+) prior to hematopoietic cell transplant (HCT), have 30% incidence of clinically significant CMV reactivation in the absence of prophylaxis. At our institution, letermovir prophylaxis through Day 100 is used in CMV R+ high-risk (HR) (cord blood, haplocord, haploidentical) HCT recipients. We hypothesized that clinically nonsignificant CMV reactivation during letermovir prophylaxis may lead to reconstitution of CMV specific cell mediated immunity (CMV CMI), which may protect the host against CMV disease after letermovir d

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Dunbar, P. R., J. Hill, and T. J. Neale. "Urinary Neopterin Quantification Indicates Altered Cell-Mediated Immunity in Healthy Subjects under Psychological Stress." Australian & New Zealand Journal of Psychiatry 27, no. 3 (1993): 495–501. http://dx.doi.org/10.3109/00048679309075808.

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In an effort to quantify changes in cell-mediated immunity (CMI) in healthy subjects under stress, we measured levels of neopterin, a well-validated marker of CMI activation, in the urine of medical students undergoing academic examinations. Neopterin/creatinine ratios measured on the first day of examinations (mean 46 μmol/mol) were significantly lower than those measured two weeks before (mean 78 μmol/mol, p =. 004). Minimum neopterin production coincided with maximum subjective stress, as measured by a visual analogue scale. After examinations, neopterin/creatinine ratios rose (means 62 μmo

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10

Kelly, Kathleen A., Heather L. Gray, Jennifer C. Walker, Roger G. Rank, Floyd L. Wormley, and Paul L. Fidel. "Chlamydia trachomatis Infection Does Not Enhance Local Cellular Immunity against Concurrent CandidaVaginal Infection." Infection and Immunity 69, no. 5 (2001): 3451–54. http://dx.doi.org/10.1128/iai.69.5.3451-3454.2001.

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ABSTRACT Although Th1-type cell-mediated immunity (CMI) is the predominant host defense mechanism against mucosal Candida albicansinfection, CMI against a vaginal C. albicans infection in mice is limited at the vaginal mucosa despite a strongCandida-specific Th1-type response in the draining lymph nodes. In contrast, Th1-type CMI is highly effective against an experimental Chlamydia trachomatis genital tract infection. This study demonstrated through two independent designs that a concurrent Candida and Chlamydia infection could not accelerate or modulate the anti-Candida CMI response. Togethe

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11

BELL, S. J. D., D. A. COOPER, B. E. KEMP, R. R. DOHERTY, and R. PENNY. "Heterogeneous effects of exogenous IL-2 on HIV-specific cell-mediated immunity (CMI)." Clinical & Experimental Immunology 90, no. 1 (2008): 6–12. http://dx.doi.org/10.1111/j.1365-2249.1992.tb05823.x.

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Thomas, Stephen J., Joachim Hombach, and Alan Barrett. "Scientific consultation on cell mediated immunity (CMI) in dengue and dengue vaccine development." Vaccine 27, no. 3 (2009): 355–68. http://dx.doi.org/10.1016/j.vaccine.2008.10.086.

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Domer, J. E., R. E. Garner, and R. N. Befidi-Mengue. "Mannan as an antigen in cell-mediated immunity (CMI) assays and as a modulator of mannan-specific CMI." Infection and Immunity 57, no. 3 (1989): 693–700. http://dx.doi.org/10.1128/iai.57.3.693-700.1989.

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Sidler, Daniel, Alexander Born, Simeon Schietzel, et al. "Trajectories of humoral and cellular immunity and responses to a third dose of mRNA vaccines against SARS-CoV-2 in patients with a history of anti-CD20 therapy." RMD Open 8, no. 1 (2022): e002166. http://dx.doi.org/10.1136/rmdopen-2021-002166.

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BackgroundThe majority of patients with B-cell-depleting therapies show compromised vaccination-induced immune responses. Herein, we report on the trajectories of anti-SARS-CoV-2 immune responses in patients of the RituxiVac study compared with healthy volunteers and investigate the immunogenicity of a third vaccination in previously humoral non-responding patients.MethodsWe investigated the humoral and cell-mediated immune response after SARS-CoV-2 messanger RNA vaccination in patients with a history with anti-CD20 therapies. Coprimary outcomes were antispike and SARS-CoV-2-stimulated interfe

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15

Chiereghin, Angela, Gabriella Verucchi, and Tiziana Lazzarotto. "CMV-Specific Cell-Mediated Immunity in Immunocompetent Adults with Primary CMV Infection: A Case Series and Review of the Literature." Viruses 13, no. 5 (2021): 816. http://dx.doi.org/10.3390/v13050816.

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Cytomegalovirus-specific cell-mediated immunity (CMV-CMI) in actively infected healthy immunocompetent hosts has been poorly investigated. Conversely, correlates of maternal protective immunity for the fetus after primary infection in pregnancy continue to be studied. The kinetics and magnitude of CMV-specific CMI in immunocompetent primary CMV-infected adults are described. A literature review on CMV-CMI in primarily infected pregnant women and its correlation to the risk of vertical virus transmission is included. Immunological measurements after infection were performed by enzyme-linked Imm

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16

Fidel, Paul L., Wei Luo, Chad Steele, Joseph Chabain, Marc Baker, and Floyd Wormley. "Analysis of Vaginal Cell Populations during Experimental Vaginal Candidiasis." Infection and Immunity 67, no. 6 (1999): 3135–40. http://dx.doi.org/10.1128/iai.67.6.3135-3140.1999.

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ABSTRACT Studies with an estrogen-dependent murine model of vaginal candidiasis suggest that local cell-mediated immunity (CMI) is more important than systemic CMI for protection against vaginitis. The present study, however, showed that, compared to uninfected mice, little to no change in the percentage or types of vaginal T cells occurred during a primary vaginal infection or during a secondary vaginal infection where partial protection was observed. Furthermore, depletion of polymorphonuclear leukocytes (PMN) had no effect on infection in the presence or absence of pseudoestrus. These resul

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17

Batista, Luís Fábio S., Carmen M. Sandoval Pacheco, Gabriela V. Araujo Flores, et al. "Molecular Insights into Cell-Mediated Immunity in Atypical Non-Ulcerated Cutaneous Leishmaniasis." Microorganisms 13, no. 2 (2025): 413. https://doi.org/10.3390/microorganisms13020413.

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Leishmania (Leishmania) infantum chagasi infections range from asymptomatic (AS) to severe visceral leishmaniasis (VL). One of the manifestations is an atypical non-ulcerated cutaneous leishmaniasis (NUCL), which occurs in some locations of Central America with few cases of VL. We conducted a transcriptomic analysis of cell-mediated immunity (CMI) on blood samples from NUCL, AS, VL patients from Amapala, Honduras, and healthy controls. RNA-seq revealed a similar perturbation of gene expression in NUCL and AS. Eight gene signatures of CMI were found in NUCL involved in CD8+ T lymphocyte infiltr

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18

Boeckl, Katharina, Edith Reuschel, Sascha Barabas, Hanna Bendfeldt, Ludwig Deml, and Birgit Seelbach-Göbel. "Functional impairment of CMV-reactive cellular immunity during pregnancy." Journal of Immunology 196, no. 1_Supplement (2016): 217.34. http://dx.doi.org/10.4049/jimmunol.196.supp.217.34.

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Abstract Background Cytomegalovirus (CMV) is the most common congenital viral infection. Mother-to child transmission (MTCT) can cause severe disability of the child. Intact CMV-specific cell-mediated immunity (CMI) has been shown to prevent uncontrolled replication in healthy individuals. In this study we aim to determine whether CMV-specific CMI is impaired in pregnant women, thus increasing the overall risk for active CMV replication and transmission. Methods CMV-specific CMI in peripheral blood of 61 pregnant women in the three trimenons of their pregnancy has been determined using T-Track

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19

Ghandour, Lina, Wissam Yaacoub, and George F. Araj. "Assessing COVID IGRA and IgG antibodies in healthcare workers post vaccination." Journal of Infection in Developing Countries 19, no. 05 (2025): 654–60. https://doi.org/10.3855/jidc.20732.

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Introduction: This study evaluated the durability of humoral and cell-mediated immunity (CMI) post Pfizer vaccination among healthcare workers (HCWs) at a tertiary care center in Lebanon. Methodology: A total of 42 HCWs were enrolled, with their past infection and/or vaccination duration ranging between 2 months and 2 years. Blood samples were tested for COVID CMI and humoral immunity simultaneously. Testing for COVID CMI was done by measuring the interferon gamma-release assay (IGRA) using the QuantiFERON SARS-CoV-2 test, and for COVID humoral immunity using the lateral flow Cellex qSARS-CoV-

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Ahn, So Yeon, Chau Thuy Tien Le, and Eun-Ju Ko. "Monophosphoryl Lipid A and Poly I:C Combination Adjuvant Promoted Ovalbumin-Specific Cell Mediated Immunity in Mice Model." Biology 10, no. 9 (2021): 908. http://dx.doi.org/10.3390/biology10090908.

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Induction of antigen-specific cell-mediated immunity (CMI), as well as humoral immunity, is critical for successful vaccination against various type of pathogens. Toll-like receptor (TLR) agonists have been developed as adjuvants to promote vaccine efficacy and induce appropriate immune responses. Monophosphoryl lipid A (MPL); a TLR4 agonist, and Poly I:C; a TLR3 agonist, are known as a strong immuno-stimulator which induce Th1 response. Many studies proved and compared the efficacy of each adjuvant, but no study has investigated the combination of them. Using ovalbumin protein antigen, MPL+Po

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Boontham, P., P. Chandran, A. Robins, M. Cámara, B. Rowlands, and O. Eremin. "QUORUM SENSING MOLECULES (QSMS) MODULATE CELL-MEDIATED IMMUNITY (CMI) IN VITRO AND IN VIVO." Shock 21, Supplement (2004): 34. http://dx.doi.org/10.1097/00024382-200403001-00136.

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Kniker, William T. "Cell-Mediated Immunity Assessed by Multitest CMI Skin Testing in Infants and Preschool Children." Archives of Pediatrics & Adolescent Medicine 139, no. 8 (1985): 840. http://dx.doi.org/10.1001/archpedi.1985.02140100102044.

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Weinberg, Adriana, and Gregory B. Pott. "Immunity to Human Immunodeficiency Virus (HIV) in Children with Chronic HIV Infection Receiving Highly Active Antiretroviral Therapy." Clinical Diagnostic Laboratory Immunology 10, no. 5 (2003): 821–25. http://dx.doi.org/10.1128/cdli.10.5.821-825.2003.

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ABSTRACT Our objective was to describe the CD4-mediated human immunodeficiency virus (HIV)-specific cell-mediated immunity (CMI) and its virologic and immunologic correlates in children with chronic HIV infection on highly active antiretroviral therapy (HAART). Twelve HIV-infected children on stable antiretroviral therapy with a median level of CD4+ lymphocytes (CD4%) of 25.5% and a median viral load (VL) of 786 HIV RNA copies/ml were enrolled in this study. Nine of these children were also cytomegalovirus (CMV) seropositive. Blood mononuclear cells, stimulated with HIV and CMV antigens, were

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Mettelman, Robert C., Aisha Souquette, Lee-Ann Van de Velde, et al. "Defining cellular correlates of protection and vaccine failure to influenza across two human cohorts." Journal of Immunology 206, no. 1_Supplement (2021): 103.37. http://dx.doi.org/10.4049/jimmunol.206.supp.103.37.

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Abstract Influenza viruses are endemic viral pathogens causing mild to severe respiratory illness in humans. Immunologic protection against influenza is determined by immune correlates of protection– factors associated with reduced infection or severe disease. While antibodies specific to viral surface proteins are known correlates, waning seasonal vaccine efficacy and reported infection of patients despite elevated antibody titers suggest that humoral responses alone do not provide complete protective immunity. Indeed, evidence points to a larger role for cell-mediated immunity (CMI; innate c

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Pomorska-Mól, Małgorzata, Iwona Markowska-Daniel, and Jarosław Rachubik. "Development of Early Humoral and Cell-Mediated Immunity in Piglets with Experimentally Induced Subclinical Swine Influenza." Bulletin of the Veterinary Institute in Pulawy 56, no. 2 (2012): 133–37. http://dx.doi.org/10.2478/v10213-012-0024-2.

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Abstract Development of early immune response in piglets with subclinical swine influenza was investigated. Fourteen, seronegative piglets were used. Ten of them were infected intranasally with swine influenza virus (SIV) H1N1 subtype. Temperature and clinical signs were assessed daily. Leukocyte proportions and concentrations were analysed on a haematology analyser. Antibodies against SIVs were measured by haemagglutination inhibition assay. To measure influenza-specific cell-mediated immunity (CMI), the proliferation assay was performed. The real time reverse transcription PCR method was use

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GABUTTI, G., M. BERGAMINI, P. BONANNI, et al. "Assessment of humoral and cell-mediated immunity againstBordetella pertussisin adolescent, adult, and senior subjects in Italy." Epidemiology and Infection 136, no. 11 (2008): 1576–84. http://dx.doi.org/10.1017/s0950268807000192.

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SUMMARYHumoral and cell-mediated immunity (CMI) againstB. pertussiswas assessed in a sample of adolescent, adult and senior subjects distributed in five different geographical areas in Italy. Most (99·1%) subjects had IgG anti-pertussis toxin (PT) antibodies exceeding the minimum detection level [⩾2 ELISA units (EU)/ml]. There were no significant differences between the genders; 6·2% samples recorded titres ⩾100 EU/ml. CMI was positive [stimulation index (SI) ⩾5] against PT in 39·0% of all samples. This study suggests thatB. pertussiscontinues to circulate in age groups that have been previous

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Matsui, Katsuhiko, and Toshihiko Arai. "Specificity ofSalmonellaPorin as an Eliciting Antigen for Cell-Mediated Immunity (CMI) Reaction in Murine Salmonellosis." Microbiology and Immunology 33, no. 12 (1989): 1063–67. http://dx.doi.org/10.1111/j.1348-0421.1989.tb03165.x.

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Zullo, F., D. L. Fulgham, M. Porta, L. Mountain, G. De Placid, and N. J. Alexander. "Relevance of cell-mediated immunity (CMI) and local immunity in the implementation of an antifertility vaccine in CD1 mice." Journal of Reproductive Immunology 15 (July 1989): 175. http://dx.doi.org/10.1016/0165-0378(89)90349-5.

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Probst, Varvara, Christopher P. Ouellette, and Eunkyung Song. "Evaluation of CMV T-cell Mediated Immunity in Children with CMV DNAemia After Allogeneic Hematopoietic Cell Transplantation." Journal of the Pediatric Infectious Diseases Society 13, Supplement_4 (2024): 23. http://dx.doi.org/10.1093/jpids/piae093.063.

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Abstract Background Cytomegalovirus (CMV) is among the most common infectious complications following allogeneic hematopoietic cell transplantation (allo-HCT). A commercially available CMV T-cell immune panel (CMV-TCIP, Viracor®), reported as percentages of CMV-specific interferon gamma releasing CD4 and CD8 cells (%CMV-CD4 or %CMV-CD8 IFN-γ), may be used to assess CMV cell-mediated immunity (CMV-CMI). However, the utility of this assay among pediatric allo-HCT recipients remains unknown. Methods A retrospective analysis among pediatric allo-HCT recipients (age ≤18 years) from 1/2020 to 11/202

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Rummel, Thomas, Joan Batchelder, Patrick Flaherty, et al. "CD28 Costimulation Is Required for the Expression of T-Cell-Dependent Cell-Mediated Immunity against Blood-Stage Plasmodium chabaudi Malaria Parasites." Infection and Immunity 72, no. 10 (2004): 5768–74. http://dx.doi.org/10.1128/iai.72.10.5768-5774.2004.

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ABSTRACT Mice suppress the parasitemia of acute blood-stage Plasmodium chabaudi malaria by an antibody- or T-cell-dependent cell-mediated mechanism of immunity (AMI and CMI, respectively) or by both mechanisms. To determine whether CD28 costimulation is required for expression of these polar immune responses, we first compared the time courses of P. chabaudi malaria in CD28-deficient (CD28−/−) and CD28-intact (CD28+/+) mice. Acute infections in both knockout (KO) and control mice followed similar time courses, with the period of descending parasitemia being prolonged ∼2 weeks in KO mice follow

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Ryu, Hoon, Haeng Yoeng Mo, Gui Dal Mo, et al. "Delayed Cutaneous Hypersensitivity Reactions in Qigong (Chun Do Sun Bup) Trainees by Multitest Cell Mediated Immunity." American Journal of Chinese Medicine 23, no. 02 (1995): 139–44. http://dx.doi.org/10.1142/s0192415x95000183.

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To determine the difference of cellular immunity between a Qigong trainee group and a normal healthy group, skin tests for delayed cutaneous hypersensitivity (DCH) were carried out with ubiquitous seven antigens. The maximal antigen response time was faster in Qigong trainee group (24 hr) and the response antigen number was also higher in the Qigong trainee group (6 antigens) than in normal healthy person (48 hr and 4 antigens). Qigong trainee also had a larger induration diameter (5.14 mm) than normal healthy person (3.79 mm) at 24 hr. Our results represent the difference in cell mediated imm

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Weidanz, William P., GayeLyn LaFleur, Andrew Brown, James M. Burns, Irene Gramaglia та Henri C. van der Heyde. "γδ T Cells but Not NK Cells Are Essential for Cell-Mediated Immunity against Plasmodium chabaudi Malaria". Infection and Immunity 78, № 10 (2010): 4331–40. http://dx.doi.org/10.1128/iai.00539-10.

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ABSTRACT Blood-stage Plasmodium chabaudi infections are suppressed by antibody-mediated immunity and/or cell-mediated immunity (CMI). To determine the contributions of NK cells and γδ T cells to protective immunity, C57BL/6 (wild-type [WT]) mice and B-cell-deficient (JH−/− ) mice were infected with P. chabaudi and depleted of NK cells or γδ T cells with monoclonal antibody. The time courses of parasitemia in NK-cell-depleted WT mice and JH−/− mice were similar to those of control mice, indicating that deficiencies in NK cells, NKT cells, or CD8+ T cells had little effect on parasitemia. In con

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A, Abdelmoktader. "Mycobacterial Tuberculosis Epidemiology and Pathogenesis." Virology & Immunology Journal 4, no. 4 (2020): 1–7. http://dx.doi.org/10.23880/vij-16000259.

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Mycobacterium tuberculosis (MTB) is an acid fast bacterium (AFB); it has tough cell wall and circular chromosome. It is transmitted through the airborne route and cause tuberculosis (TB). The distribution of tuberculosis is not uniform across the globe; about 80% of the population in many Asian and African countries and it is the second most common cause of death from infectious disease after HIV. Organisms deposited mainly in the upper lung zones, kidneys and bones. In persons with intact cell-mediated immunity (CMI), collections of activated T cells and macrophages form granulomas that limit

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Meyer, Claudius U., Fred Zepp, Michael Decker, et al. "Cellular Immunity in Adolescents and Adults following Acellular Pertussis Vaccine Administration." Clinical and Vaccine Immunology 14, no. 3 (2007): 288–92. http://dx.doi.org/10.1128/cvi.00364-06.

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ABSTRACT Cell-mediated immune (CMI) responses to an acellular pertussis vaccine administered to 49 subjects, a subset of participants in the National Institutes of Health-funded adult acellular pertussis vaccine efficacy trial, were evaluated and compared with antibody responses to vaccine antigens. Levels of proliferation of and cytokine secretion from lymphocytes cultured in the presence of pertussis toxin, filamentous hemagglutinin, or pertactin were measured before vaccination and 1 month and 1 year after vaccination. Statistically significant increases in lymphocyte stimulation indices an

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Reber, Adrian, Nedzad Music, and Ian York. "Extensive cell-mediated cross-reactivity between diverse influenza strains in the ferret model (VIR5P.1143)." Journal of Immunology 194, no. 1_Supplement (2015): 148.11. http://dx.doi.org/10.4049/jimmunol.194.supp.148.11.

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Abstract Influenza causes widespread epidemics affecting the world’s population. The virus achieves this on a yearly basis due to its ability to escape prior immunity by rapidly mutating surface proteins, the target of neutralizing antibodies. In contrast, the internal viral proteins, targets of the cell-mediated immune (CMI) response, are highly conserved, and have potential for cross-protection. However, little has been done to comprehensively evaluate the true extent of CMI cross-reactivity between influenza strains. Unvaccinated or vaccinated ferrets were challenged with 2008-2009 pandemic

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Marshall, Jason D., Marianne L. Gesner, Darren S. Heeke, Brian Livingston, and Gary Van Nest. "ISS (ImmunoStimulatory Sequences) and Iscomatrix boost vaccine-generated HBV-specific immunity in mice (B202)." Journal of Immunology 178, no. 1_Supplement (2007): LB42. http://dx.doi.org/10.4049/jimmunol.178.supp.b202.

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Abstract We have investigated the adjuvant activity of both CpG motif-containing ImmunoStimulatory Sequences (ISS) and the saponin/phospholipid-based Iscomatrix (IMX) on HBV-specific humoral and cell-mediated immunity in C57BL/6 mice. Mice were immunized at weeks 0 and 2 with several formulations that incorporated HBV surface antigen (HBsAg), HBV core antigen (HBcAg), ISS, and IMX. ISS was added to antigen in soluble form or conjugated with HBsAg or HBcAg. Bleeds were performed 2 weeks post 1st immunization (2wp1) and 2wp2 and sera analyzed for anti-HBV IgG1 and IgG2a levels. Mice were also sp

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Coffman, Jonathan A. "Enteroviruses Activate Cellular Innate Immune Responses Prior to Adaptive Immunity and Tropism Contributes to Severe Viral Pathogenesis." Microorganisms 13, no. 4 (2025): 870. https://doi.org/10.3390/microorganisms13040870.

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Numerous innate immune mechanisms have been shown to be activated during viral infections, including pattern recognition receptors (PRRs) functioning outside and inside the cell along with other sensors promoting the production of interferon and other cytokines. Innate cells, including NK cells, NKT cells, γδ T cells, dendritic cells, macrophages, and even neutrophils, have been shown to respond to viral infections. Several innate humoral responses to viral infections have also been identified. Adaptive immunity includes common cell-mediated immunity (CMI) and humoral responses. Th1, Th2, and

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Davitt, Christopher JH, Hailey E. Petersen, Nicole L. Kikendall, Edward C. Lavelle, and Lisa A. Morici. "Naturally-derived bacterial nano-particles engage diverse innate receptors, driving the activation of dendritic cells and leading to the establishment of potent adaptive immune responses." Journal of Immunology 196, no. 1_Supplement (2016): 76.11. http://dx.doi.org/10.4049/jimmunol.196.supp.76.11.

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Abstract Most non-living vaccines in clinical use are thought to mediate protection primarily via antibody responses; however, many intracellular bacterial infections require cell-mediated immunity (CMI) for protection. This renders traditional strategies insufficient and drives a need for new approaches to elicit CMI. Outer-membrane vesicles (OMVs) derived from Gram-negative bacteria are an effective vaccine platform with precedence for safe use in humans. Unlike most subunit antigens and synthetic nano-particles, OMVs contain endogenous immunostimulatory ligands and deliver antigens in their

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Groth, Nicola, Jacques Bruhwyler, Jessika Tourneur, et al. "Safety and Immunogenicity of OVX836, a Nucleoprotein-Based Universal Influenza Vaccine, Co-Administered with Fluarix® Tetra, a Seasonal Hemagglutinin-Based Vaccine." Vaccines 13, no. 6 (2025): 558. https://doi.org/10.3390/vaccines13060558.

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Background/Objectives: The combination of a hemagglutinin antigen (HA)-based inactivated influenza vaccine (IIV; Fluarix® Tetra; GlaxoSmithKline) with a nucleoprotein (NP)-based vaccine, such as OVX836, should increase the efficacy of influenza vaccines since it leverages two complementary immunological mechanisms: HA antibodies targeting the virus envelope and neutralizing it, and an NP cell-mediated immune (CMI) response destroying infected cells. Methods: This was a randomized, double-blind, Phase 2a study (ClinicalTrials.gov NCT05284799) including three groups of 60 healthy subjects (18–55

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Chaudhari, Ramesh, Nikunj Tandel, Kiran Sahu, et al. "Transdermal Immunization of Elastic Liposome-Laden Recombinant Chimeric Fusion Protein of P. falciparum (PfMSP-Fu24) Mounts Protective Immune Response." Nanomaterials 11, no. 2 (2021): 406. http://dx.doi.org/10.3390/nano11020406.

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Transdermal immunization exhibits poor immunogenic responses due to poor permeability of antigens through the skin. Elastic liposomes, the ultradeformable nanoscale lipid vesicles, overcome the permeability issues and prove a versatile nanocarrier for transcutaneous delivery of protein, peptide, and nucleic acid antigens. Elastic liposome-mediated subcutaneous delivery of chimeric fusion protein (PfMSP-Fu24) of Plasmodium falciparum exhibited improved immunogenic responses. Elastic liposomes-mediated immunization of PfMSP-Fu24 conferred immunity to the asexual blood-stage infection. Present st

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Carryn, Stephane, Brigitte Cheuvart, Michael Povey, et al. "No Consistent Evidence of Decreased Exposure to Varicella-Zoster Virus Among Older Adults in Countries with Universal Varicella Vaccination." Journal of Infectious Diseases 225, no. 3 (2021): 413–21. http://dx.doi.org/10.1093/infdis/jiab500.

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Abstract Background Universal varicella vaccination might reduce opportunities for varicella-zoster virus (VZV) exposure and protective immunological boosting, thus increasing herpes zoster incidence in latently infected adults. We assessed humoral and cell-mediated immunity (CMI), as markers of VZV exposure, in adults aged ≥50 years. Methods We repurposed data from placebo recipients in a large multinational clinical trial (ZOE-50). Countries were clustered based on their varicella vaccination program characteristics, as having high, moderate, or low VZV circulation. Anti-VZV antibody geometr

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Carryn, Stephane, Brigitte Cheuvart, Michael Povey, et al. "No Consistent Evidence of Decreased Exposure to Varicella-Zoster Virus Among Older Adults in Countries with Universal Varicella Vaccination." Journal of Infectious Diseases 225, no. 3 (2021): 413–21. http://dx.doi.org/10.1093/infdis/jiab500.

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Abstract Background Universal varicella vaccination might reduce opportunities for varicella-zoster virus (VZV) exposure and protective immunological boosting, thus increasing herpes zoster incidence in latently infected adults. We assessed humoral and cell-mediated immunity (CMI), as markers of VZV exposure, in adults aged ≥50 years. Methods We repurposed data from placebo recipients in a large multinational clinical trial (ZOE-50). Countries were clustered based on their varicella vaccination program characteristics, as having high, moderate, or low VZV circulation. Anti-VZV antibody geometr

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Bakke, Brock, Chandranaik Marinaik, Randall Toy, et al. "Programming effective respiratory immunity to influenza with combination microparticle adjuvants." Journal of Immunology 204, no. 1_Supplement (2020): 166.29. http://dx.doi.org/10.4049/jimmunol.204.supp.166.29.

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Abstract T cell-mediated immunity (CMI) can provide long-lived protection following parenteral immunization, but eliciting durable and protective CMI in the mucosa remains a significant challenge. Here, using polylactic-co-glycolic acid (PLGA)-based cationic pathogen-like particles (PLPs) for delivery of TLR agonists, we have investigated novel ways of presenting vaccine components to the immune system to simulate the potent innate immune stimulating effects of pathogens. We generated micro particle sized PLPs loaded with TLR4 (glucopyranosyl lipid adjuvant, GLA) and/or TLR9 (CpG) agonists, an

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van, Doorn Eva, Olga Pleguezuelos, Heng Liu, et al. "Evaluation of the immunogenicity and safety of different doses and formulations of a broad spectrum influenza vaccine (FLU-v) developed by SEEK: study protocol for a single-center, randomized, double-blind and placebo-controlled clinical phase IIb trial." BMC Infectious Diseases 17, no. 1 (2017): 241. https://doi.org/10.1186/s12879-017-2341-9.

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<strong>Background: </strong>Current influenza vaccines, based on antibodies against surface antigens, are unable to provide protection against newly emerging virus strains which differ from the vaccine strains. Therefore the population has to be re-vaccinated annually. It is thus important to develop vaccines which induce protective immunity to a broad spectrum of influenza viruses. This trial is designed to evaluate the immunogenicity and safety of FLU-v, a vaccine composed of four synthetic peptides with conserved epitopes from influenza A and B strains expected to elicit both cell mediated

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Tseraidi, N. F. "Immunosuppression in patients with syphilis and problems of human immunodeficiency virus infection." Acta Dermato-Venereologica 74, no. 4 (1994): 317–19. http://dx.doi.org/10.2340/0001555574320322.

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An investigation of the induced suppression and cytotoxicity of T lymphocytes, carried out in 57 patients with different forms of syphilis, has made it possible to find some reasons for the depression of cell-mediated immunity (CMI) in patients with early syphilis. The analysis of the immunoreaction of patients with different forms of syphilis clarifies the influence of the human immunodeficiency virus (HIV) on the dynamics and formation of syphilis manifestations.

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Boo-Chai, Khoo. "Cell mediated immunity (CMI) in patients of oral cancer and oral leucoplakia. Indian J. Surg. 46." Plastic and Reconstructive Surgery 77, no. 1 (1986): 176. http://dx.doi.org/10.1097/00006534-198601000-00104.

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Adams, Amanda A., and David W. Horohov. "The effect of an immunomodulator (parapoxvirus ovis) on cell-mediated immunity (CMI) in abruptly weaned foals." Veterinary Immunology and Immunopathology 153, no. 1-2 (2013): 118–22. http://dx.doi.org/10.1016/j.vetimm.2012.11.020.

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Huaping, Liang. "The effect of Astragalus polysaccharides (APS) on cell mediated immunity (CMI) in burned mice. (Chinese) Chin." Plastic and Reconstructive Surgery 96, no. 7 (1995): 1759. http://dx.doi.org/10.1097/00006534-199512000-00078.

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Mojadadi, Shafi, Abbas Jamali, Behzad Khansarinejad, Hoorieh Soleimanjahi, and Taravat Bamdad. "Acute Morphine Administration Reduces Cell-Mediated Immunity and Induces Reactivation of Latent Herpes Simplex Virus Type 1 in BALB/c Mice." Cellular & Molecular Immunology 6, no. 2 (2009): 111–16. http://dx.doi.org/10.1038/cmi.2009.15.

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Cho, Yun Sang, Sang Eun Lee, Youngboo Jang, Sukchan Jung, and Jong Man Kim. "Identification of B cell antigenome in Mycobacterium bovis by immunoproteomic analysis." Acta Veterinaria Hungarica 68, no. 2 (2020): 123–29. http://dx.doi.org/10.1556/004.2020.00019.

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AbstractBovine tuberculosis (bTB) is a common zoonosis prevalent in many countries with grave economic consequences. Most developed and developing countries have implemented the test-and-slaughter policy to protect public health and reduce economic losses in the cattle industry. The official diagnosis of bTB is based on assays dependent on cell-mediated immunity (CMI). CMI-based diagnosis demonstrates diagnostic incapability at late stages of infection, which could be overcome by diagnosis based on humoral immunity (HI). Therefore, there is an urgent need to identify and define the B cell anti

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