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Rozprawy doktorskie na temat „Characteristics of salmonella paratyphi”

Autor: Grafiati

Data publikacji: 3 czerwca 2025

Data aktualizacji: 31 lipca 2025

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1

Maharjan, Sabina. "Antimicrobial resistance and gallbladder carriage of Salmonella Typhi and Salmonella Paratyphi A in Kathmandu, Nepal." Thesis, University of Oxford, 2013. http://ora.ox.ac.uk/objects/uuid:f303e4c4-90c9-4e50-be8e-682ac1e38512.

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Enteric fever remains the most common febrile illness in urban Nepal. Some individuals may have recurrent infection and some may even progress to become long term chronic carriers. The aim of this thesis was to investigate the rate and factors leading to relapse with typhoid fever in patients who were enrolled in clinical treatment trials for acute enteric fever. The results show that relapses in enteric fever is a common complication and is more likely to be associated with the treatment antimicrobial, cefixime. Gallbladder carriage of invasive Salmonella is considered fundamental in sustaini

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2

Mason, John Nicholas. "Effects of conalbumin bound iron on the growth of Salmonella paratyphi B and Salmonella thompson." PDXScholar, 1991. https://pdxscholar.library.pdx.edu/open_access_etds/4381.

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I have investigated the possibility that specific conalbumin (ovotransferrin) iron saturation levels enable less virulent strains of Salmonella to become more virulent. Iron starved cells of two pathogenic Salmonella strains, S. paratyphi B var. java and S. thompson, were cultured in iron limited media at 3 different iron conalbumin saturation levels. Results indicate that strains differ significantly at both low and high iron saturation conalbumin. These differences depict a growth advantage for S. paratyphi B which correlates with reports by the Centers for Disease Control that S. paratyphi

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3

Holt, K. E. "Genomic variation and evolution of Salmonella enterica serovars Typhi and Paratyphi A." Thesis, University of Cambridge, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.604198.

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In this thesis, comparative genomic analysis was used to detect variation within the Typhi and Paratyphi A populations, and to compare the evolution of these two pathogens. There was evidence in both populations of ongoing accumulation of inactivating mutations which result in loss of gene function. Detailed comparison of this functional gene loss in Typhi and Paratyphi A revealed that many of the same genes were inactivated in both serovars, but the mutations occurred independently and were not the result of horizontal transfer of DNA between their genomes. Comparative analysis found that the

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4

Verma, Naresh K. "Genetic basis of O-antigen variation in Salmonella spp.: rfb gene clusters of S. typhi and S. paratyphi A." Thesis, The University of Sydney, 1988. https://hdl.handle.net/2123/26037.

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The O—antigens of Salmonella serogroups A, B and D differ structurally in their side-chain sugar residue. The genes encoding 0antigen biosynthesis are clustered in the rfb operon. This thesis describes the molecular cloning and analysis of the rfb genes from S. paratyphi A IMVSl316 (serogroup A) and S. typhi Ty21a (serogroup D). The rfb gene cluster from S. Typhimurium LT2 (serogroup B) has also been studied in our laboratory (Brahmbhatt et al 1986, 1988; P. Wyk, Ph.D. thesis, Univ. of Adelaide, 1988). The genetic basis of O-antigen variation in serogroups A, B and D of Salmonella is dscussed.

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5

Kloska, Franziska [Verfasser]. "Infektionsdynamik von Salmonella Paratyphi B d-Tartrat+ im Masthähnchenbestand sowie deren Bekämpfung in der Primärproduktion / Franziska Kloska." Hannover : Bibliothek der Tierärztlichen Hochschule Hannover, 2017. http://d-nb.info/1136277919/34.

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Sepe, Ludovico Pasquale [Verfasser]. "Generation of gallbladder organoids to study the genotoxic effect mediated by Salmonella Paratyphi A / Ludovico Pasquale Sepe." Berlin : Freie Universität Berlin, 2018. http://d-nb.info/1158597657/34.

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Ménard, Renaud. "Manifestations cardio-vasculaires des salmonelles, à propos d'une observation d'une péricardo-myocardite aigue͏̈ à Salmonella paratyphi A." Bordeaux 2, 1996. http://www.theses.fr/1996BOR2M026.

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MONTAGNESE, YANNICK. "Les endocardites a salmonelles : revue de la litterature a propos d'une observation d'une endocardite tricuspidienne a salmonella paratyphi a chez l'adolescent." Lille 2, 1992. http://www.theses.fr/1992LIL2M043.

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Lara, Calvario Sebastian Laerzio. "Adición de Lactobacillus farciminis (probiótico) en la dieta de pollos de engorda (Gallus gallus) en desafió con una cepa de Salmonella paratyphi." Tesis de Licenciatura, Universidad Autónoma del Estado de México, UAEM, 2017. http://hdl.handle.net/20.500.11799/67724.

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El objetivo del trabajo fue evaluar la salud intestinal en pollos bajo la adición a su dieta de un probiótico proporcionado por la empresa SAFISIS (Es una empresa de biotecnología especializada en el desarrollo de ingredientes naturales a través de medios microbiológicos para la Industria de alimentos y bebidas, así como para los mercados nutracéuticos y farmacéuticos), un lactobacilo de la especie Lactobacillus farciminis y desafiados con una cepa de Salmonella paratyphi. Se usaron un total de 120 pollos de 3 días de nacidos, los cuales fueron divididos en cuatro grupos: el primer grup

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10

Folk, Mary Kay. "Identifying Production Facility Characteristics in Small and Very Small Meat Processing Plants with Reference to FSIS Salmonella Test Results." Columbus, Ohio : Ohio State University, 2008. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1218552809.

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11

Das, Elif. "Effect Of Controlled Atmosphere Storage, Modified Atmosphere Packaging And Gaseous Ozone Treatment On The Survival Characteristics Of Salmonella Enteritidis At Cherry Tomatoes." Master's thesis, METU, 2004. http://etd.lib.metu.edu.tr/upload/12605337/index.pdf.

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iv In recent years, outbreaks of infections associated with raw and minimally processed fruits and vegetables have been reported. Possible sources for contamination are irrigation water, manure, wash water, handling by workers and contact with contaminated surfaces. Pathogens can occur on raw and minimally processed produce at populations ranging from 103 to 109 CFU/g and able to survive and sometimes grow under various storage conditions. The objective of this study was to analyse the growth/survival of Salmonella Enteritidis at spot-inoculated or stem-injected cherry tomatoes during passive

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12

Arjyal, Amit. "Clinical studies on enteric fever." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:7b82ceef-96de-4159-adcf-a06dc14c581a.

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I performed two randomised controlled trials (RCTs) to determine the best treatments for enteric fever in Kathmandu, Nepal, an area with a high proportion of nalidixic acid resistant S. Typhi and S. Paratyphi A isolates. I recruited 844 patients with suspected enteric fever to compare chloramphenicol versus gatifloxacin. 352 patients were culture confirmed. 14/175 patients treated with chloramphenicol and 12/177 patients treated with gatifloxacin experienced treatment failure (HR=0.86 (95% CI 0.40 to 1.86), p=0.70). The median times to fever clearance were 3.95 and 3.90 days, respectively (HR=

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13

Chen, Yi An, and 陳奕安. "The difference between Salmonella Paratyphi C- and Salmonella Choleraesuis-induced programmed cell death in macrophages." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/e5z3wz.

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碩士<br>長庚大學<br>生物醫學研究所<br>105<br>Salmonella is Gram-negative bacteria and classified into two groups based on the disease patterns : typhoid serotypes and non-typhoid serotypes. Salmonella paratyphi C (SPC) is typhoid serotype and highly adapted to human which causes enteric fever. Salmonella Choleraesuis (SC) is non-typhoid serotype with broad host range and causes gastroenteritis. It is unknow why these two Salmonella with high genomic similarity make distinct clinical diseases. In this study, we aimed to compare the different level of inflammatory response and cell death mechanism in macroph

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14

Chiao, Guan Hao, and 喬冠豪. "The Difference in Interaction with Epithelial Cells and Macrophages between Salmonella Paratyphi C and Salmonella Choleraesuis." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/17016140614040900612.

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碩士<br>長庚大學<br>生物醫學研究所<br>100<br>Salmonella Paratyphi C (SPC) and S. Choleraesuis (SC) both belong to serogroup C1 Salmonella, with high genome similarity. SPC contains a Vi capsule, which is absent in SC. SPC cause paratyphoid fever in humans; however, SC usually cause gastroenteritis, and occasionally bacteremia. In this study, we used molecular and cellular microbiological methods to study the difference in cell responses to SPC and SC infection. In previous studies, S. Typhi Vi capsule can decrease host inflammation during penetrating intestinal epithelial cells, which was called stealth ph

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15

Tien, Chang Hung, and 田昌弘. "Differential host response of human macrophages infected by Salmonella Choleraesuis and S. Paratyphi C." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/56128363246825023756.

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碩士<br>長庚大學<br>生物醫學研究所<br>98<br>Salmonella Typhi and S. Paratyphi can only cause the human infection of typhoid or paratyphoid fever, while other non-typhoid Salmonella, such as S. Typhimurium, and S. Choleraesuis, usually cause gastroenteritis and bacteremia. The mechanism of host specificity in Salmonella infection remains unclear. In this study, we aimed to study the correlation between host specificity and host immune response by using transcriptomic interactome approach. We found that 872 genes in THP-1 cells and 141 in 3D4/21 cells were differentially expressed over 2-folds between the tw

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16

Kaur, Avinash. "Nucleic acid based method for the rapid diagnosis of salmonella typhi and paratyphi a." Thesis, 2018. http://localhost:8080/xmlui/handle/12345678/7694.

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Yang, Hsin Ping, and 楊欣萍. "The difference in immune response to Salmonella enterica serotypes Paratyphi C and Choleraesuis infection of macrophages." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/95609815740254535459.

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碩士<br>長庚大學<br>生物醫學研究所<br>102<br>Salmonella enterica are Gram negative bacteria that cause diseases in human or animal hosts. There are more than 2500 serotypes in S. enteria, according to the surface antigens (O, H and Vi antigen). S. enterica can be stratified into two groups based on the disease pattens : typhoid serotypes (S. Typhi and S. Paratyphi A, B, C) and non-typhoid serotypes (S. Typhimurium, S. Choleraesuis). Inflammasomes play an important role in innate immune defense against Salmonella infection, activation of inflammasome triggers significant production of IL-1β leading cells to

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18

"A study on the molecular and epidemiological characteristics of antibiotic-resistant salmonellae isolated in Hong Kong." Thesis, 2008. http://library.cuhk.edu.hk/record=b6074459.

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A total of 842 single patient isolates of Salmonella spp. from the New Territories East Cluster hospitals, Hong Kong, were collected during 2002 and 2004. The most common Salmonella enterica serotype isolated was S. Enteritidis (29.7%, 250 of 842) followed by S. Typhimurium (13.7%, 115 of 842). The remaining 29.6% (249 of 842) belonged to 44 serotypes and 27.1% (228 of 842) were non-typeable. The majority of isolates were from patients aged two years or younger and were isolated during June to October of each of the three years. The susceptibilities to 19 antimicrobial agents of the 834 isol

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19

Chia, Teck Wah Raymond. "The effect of surface structures on the physicochemical characteristics and attachment capability of Salmonella." Thesis, 2010. https://eprints.utas.edu.au/19302/1/whole_ChiaTeckWahRaymond2010_thesis.pdf.

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Salmonella enterica, one of the most important foodborne pathogens, is often acquired through the consumption of contaminated food of animal origin such as poultry and eggs. In Australia, Salmonella enterica subspecies II 4,12:b- (S. Sofia) is the predominant serovar isolated from poultry. Salmonella Sofia may be regarded as having relatively low virulence for humans as it is rarely associated with human disease in comparison with subspecies I serovars. Salmonella have been recovered from a wide range of food contact surfaces and equipment because of their ability to attach to differen

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20

Marus, Jessica R. "Outbreaks of Salmonella enterica Linked to Animal Contact: Demographic and Outbreak Characteristics and Comparison to Food Outbreaks — United States, 2009–2014." 2016. http://scholarworks.gsu.edu/iph_theses/439.

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Introduction: Each year in the United States, Salmonella enterica infections cause an estimated 1.2 million illnesses that result in 19,000 hospitalizations and 390 deaths. Illnesses occur sporadically throughout the year, but might also occur as part of an outbreak. Outbreaks are most commonly linked to a food source, but contact with live animals can also result in human outbreaks of illness. Methods: Outbreaks of Salmonella reported to the Centers for Disease Control and Prevention through National Outbreak Reporting System (NORS) from 2009–2014 with a primary mode of transmission listed as

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"EFFECT OF CONTROLLED ATMOSPHERE STORAGE, MODIFIED ATMOSPHERE PACKAGING AND GASEOUS OZONE TREATMENT ON THE SURVIVAL CHARACTERISTICS OF SALMONELLA ENTERITIDIS AT CHERRY TOMATOES." Master's thesis, METU, 2004. http://etd.lib.metu.edu.tr/upload/12605337/index.pdf.

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Chen, Wan-Ting, and 陳琬婷. "A Comparative Study on Bacterial Invasion and Effects on Survival, Nitric Oxide Responses and Proinflammatory Cytokine Secretion of Raw 264.7 Macrophages Infected by Different Antibiotic-Resistant Characteristics of Salmonella Isolates." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/09951188586656685605.

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碩士<br>國立中興大學<br>微生物暨公共衛生學研究所<br>102<br>Salmonella is an intracellular pathogen in macrophages. This characteristic can lead the organism to more likely escape from immune clearance. Systematic infection, caused by multidrug-resistant (MDR) Salmonella, is usually associated with increased morbidity in humans and increased mortality in animals relative to non-MDR strains, and may result in difficulties during clinical treatment. It is still unclear whether MDR isolates are with higher survival in macrophages and induce less proinflammatory cytokines. This study was conducted to understand bacter

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