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Rozprawy doktorskie na temat „Characterization of Microencapsulating Drug”

Autor: Grafiati

Data publikacji: 2 czerwca 2025

Data aktualizacji: 31 lipca 2025

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1

Yella, Jaswanth. "Machine Learning-based Prediction and Characterization of Drug-drug Interactions." University of Cincinnati / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=ucin154399419112613.

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2

Lee, Dong-Won. "Engineered chitosans for drug detoxification preparation, characterization, and drug uptake studies /." [Gainesville, Fla.] : University of Florida, 2004. http://purl.fcla.edu/fcla/etd/UFE0004293.

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3

Wang, Juan. "Characterization of microsphere drug delivery systems during encapsulation and initial drug release /." The Ohio State University, 2000. http://rave.ohiolink.edu/etdc/view?acc_num=osu1488202678776876.

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4

Wei, Yaoming. "Peptide deformylase : characterization and antibacterial drug design /." The Ohio State University, 2000. http://rave.ohiolink.edu/etdc/view?acc_num=osu148819244742765.

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5

Certad, Gabriela. "Characterization of drug-resistant isolates of Plasmodium falciparum." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape16/PQDD_0017/MQ37102.pdf.

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6

Sabloff, Mitchell. "Characterization and intracellular delivery of lipid-drug conjugates." Thesis, McGill University, 1993. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=68255.

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Liposomes. I.e., uni- or multilamellar lipid vesicles which can carry hydrophilic material in their interior and hydrophobie materiai within their bilayers, are an interesting potential vehicle for delivery of biologically active materials. Liposomes offer several potential advantages as carriers of various types of drugs in a variety of pharmacological applications.

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7

Roberts, Rose A. "Polymer Nanoparticle Characterization and Applications for Drug Delivery." Diss., Virginia Tech, 2019. http://hdl.handle.net/10919/104384.

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Nanoparticle usage continues to increase in everyday products, from cosmetics to food preservation coatings, drug delivery to polymer fillers. Their characterization and synthesis is of utmost importance to ensure safety and improved product quality. Nanoparticles can be sourced naturally or synthetically fabricated. Cellulose nanocrystals (CNCs) are rod-like nanoparticles that can be isolated from nature. Reliable methods of characterization are necessary to ensure quality control. However, their physical characteristics cause challenges for imaging under transmission electron microscopy (TEM

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8

Hire, S. L. "Biodegradable polymers for drug delivery: synthesis and characterization." Thesis(Ph.D.), CSIR-National Chemical Laboratory, Pune, 2011. http://dspace.ncl.res.in:8080/xmlui/handle/20.500.12252/3819.

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9

Mazumder, Sonal. "Synthesis and Characterization of Drug-Containing, Polysaccharide-Based Nanoparticles for Applications in Oral Drug Delivery." Diss., Virginia Tech, 2013. http://hdl.handle.net/10919/23692.

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Amorphous solid dispersions of polysaccharide-drug nanoparticles were produced by a rapid precipitation process known as flash nanoprecipitation and the formulation process and properties of nanoparticles were investigated. In this thesis, several novel cellulose derivatives and a pullulan derivative were studied. Among these polymers, carboxymethyl cellulose acetate butyrate (CMCAB)-drug nanoparticles were investigated in detail. Previous work has shown that the presence of different chemical groups in CMCAB could aid in complexation with hydrophobic drugs with low solubility, forming an amor

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10

Jores, Katja. "Lipid nanodispersions as drug carrier systems a physicochemical characterization /." [S.l.] : [s.n.], 2004. http://deposit.ddb.de/cgi-bin/dokserv?idn=972528334.

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11

Rosenbaum, Erik. "Optical characterization of potential drugs and drug delivery systems." Doctoral thesis, Umeå universitet, Kemiska institutionen, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-40177.

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This Thesis is a characterization study on substances having potency as drugs as well as on a lipid based drug-delivery matrix. The optical properties of newly synthesized molecules with proven pilicide properties have been characterized with several spectroscopic methods. These methods include optical absorption and fluorescence as well as time-resolved fluorescence. Upon covalently linking compounds with high quantum yields of fluorescence to specific parts of the pilicide, the biological impact was found to increase for some of the derivatives. Furthermore, by expanding the aromatic part of

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12

Narayanaswamy, Variankaval. "Characterization of phase transitions in transdermal drug delivery systems." Thesis, Georgia Institute of Technology, 1997. http://hdl.handle.net/1853/8645.

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13

Yaddanapudi, Suryanarayana. "Machine Learning Based Drug-Disease Relationship Prediction and Characterization." University of Cincinnati / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1565349706029458.

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14

Chen, Li. "Development and characterization of controlled drug delivery using nanoparticles." ScholarWorks@UNO, 2004. http://louisdl.louislibraries.org/u?/NOD,161.

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Thesis (M.S.)--University of New Orleans, 2004.<br>Title from electronic submission form. "A thesis ... in partial fulfillment of the requirements for the degree of Master of Science in the Department of Chemistry."--Thesis t.p. Vita. Includes bibliographical references.

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15

Rukasha, Ivy. "Characterization and drug resistance of Trichomonas vaginalis clinical isolates." Diss., University of Pretoria, 2013. http://hdl.handle.net/2263/30760.

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Sexually transmitted infections (STIs) are a major cause of acute illnesses, infertility, long term disability and death with far reaching health, social and economic consequences. Trichomonas vaginalis is the causative organism of trichomoniasis which classically presents in women as a malodorous green-yellowish discharge accompanied by itching and burning. In men infection can cause non-gonococcocal urethritis and chronic prostatitis. Complications of T. vaginalis include preterm delivery, low birth weight, predisposition to HIV infection and cervical cancer. Previous studies in South

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16

Birudaraj, Kondamraj. "Transbuccal drug delivery: In vitro characterization of transport pathway of buspirone and bioadhesive drug delivery system." Scholarly Commons, 2001. https://scholarlycommons.pacific.edu/uop_etds/2733.

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The objective of this research was to investigate two important aspects of buccal drug delivery, transport and mucoadhesion. Buspirone was chosen as a model drug for the in vitro buccal transport studies, polyvinyl alcohol and sodium alginate polymer blends were prepared to investigate the mucoadhesive properties through a Lewis acid-base approach and finally, the effect of formulation factors on the force of mucoadhesion, surface energy parameters, release rate and flux was studied. In vitro permeation studies were conducted to investigate the buccal transport pathway of buspirone. Mathematic

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17

Harris, Michelle J. "Characterization of Drug Resistance in Mycobacterium Tuberculosis via Saturating Mutagenesis of Drug Targets: A Master’s Thesis." eScholarship@UMMS, 2012. https://escholarship.umassmed.edu/gsbs_diss/605.

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Mycobacterium tuberculosis isolates from multiple drug resistant or extensively drug resistant patients show a particular set of mutations in drug targets conferring resistance. However, the selection of drug-resistant strains in vitro yields an alternative set of mutations, thought to result from the cost-benefit associated with drug resistance. Mutations allowing for survival under antibiotic may not be beneficial when presented with the host environment or with a drug-free environment. These fitness effects drive the natural evolution of this bacterium. Using recombineering a large cohor

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18

Chakrapani, Aravind. "Processing and characterization of polymer microparticles for controlled drug delivery systems." Columbus, Ohio : Ohio State University, 2006. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1164827297.

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19

Sidhu, Balwinder Kaur. "Flocculation characterization of metered dose inhaler suspensions." Thesis, University of Nottingham, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.335852.

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20

Crampton, Hannah Louise. "Synthesis and characterization of melamine-based dendrimers with potential biological applications." Thesis, [College Station, Tex. : Texas A&M University, 2008. http://hdl.handle.net/1969.1/ETD-TAMU-2673.

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21

Heinrich, Anne-Kathrin [Verfasser]. "Overcoming drug resistance by stimulus-sensitive drug delivery systems : a preclinical characterization of polymer-drug conjugates for the treatment of multi-drug resistant cancer / Anne-Kathrin Heinrich." Halle, 2017. http://d-nb.info/1144955262/34.

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22

Shew, Clifford R. "Characterization of liposomal drug delivery systems utilizing cell culture methods." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/NQ61174.pdf.

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23

Wu, Ming. "The micro and nano scale characterization of drug eluting stents." Thesis, University of Nottingham, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.493323.

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24

Siu, Kit-hang, and 蕭傑恆. "Molecular characterization of multi-drug resistance mechanisms in mycobacterium tuberculosis." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2010. http://hub.hku.hk/bib/B46076219.

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25

Vallotto, Claudio. "Electron paramagnetic resonance techniques for pharmaceutical characterization and drug design." Thesis, University of Warwick, 2017. http://wrap.warwick.ac.uk/104986/.

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This thesis aims to explore the applicability of Electron Paramagnetic Resonance (EPR) spectroscopy in the pharmaceutical field. EPR is a powerful biophysical tool that allows the detection and characterisation of paramagnetic species, such as free organic radicals and metal complexes. EPR is widely used across all disciplines but to date has been much underutilised in the pharmaceutical industry. In the first part of this work, EPR techniques were applied to characterise the degradation products originating from irradiation sterilization of two common excipients, L-histidine and D-mannitol. R

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26

Swan, Erin Eileen Leary 1976. "A fully implantable intracochlear drug delivery device : development and characterization." Thesis, Massachusetts Institute of Technology, 2009. http://hdl.handle.net/1721.1/55258.

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Thesis (Sc. D.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2009.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references.<br>In a collaborative effort with the Massachusetts Eye and Ear Infirmary, Draper Laboratory is developing an implantable microfluidic drug delivery system for long-term treatment of inner ear disorders and prevention of sensorineural hearing loss. This versatile device is envisioned to deliver multiple therapies and control the sequence and rate of drug dosing. Such a system could have an immediate application in the tr

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27

Cecchin, Denis. "Study and characterization of drug delivery system in regenerative medicine." Doctoral thesis, Università degli studi di Padova, 2010. http://hdl.handle.net/11577/3422729.

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Abstract Drug delivery system (DDS) technology is particularly promising to improve the in vivo efficiency of active molecules. Moreover, it is possible to stabilize and prolong the half life at biologically active molecules, thus prolonging the in vitro activity. DDS's can be used either for the delivery of anticancer drug but also for the controlled release of growth factors essential for the tissue engineering. In this work DDS’s have been investigate to develop new targeted anticancer drug or to control the release of growth factor for tissue engineering. In the first case polymer conju

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28

Vishwanathan, Anusha. "In Vitro Characterization Of Simvastatin Loaded Microspheres In The PolyRing Device." University of Akron / OhioLINK, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=akron1205934178.

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29

Prakash, Anand. "Characterization of synergistic effect of iododeoxyuridine and clofarabine in cisplatin-resistant ovarian cancer cells." Thesis, Birmingham, Ala. : University of Alabama at Birmingham, 2009. https://www.mhsl.uab.edu/dt/2009m/prakash.pdf.

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30

Van, Tyne Daria Natalie. "Identification and Characterization of Novel Drug Resistance Loci in Plasmodium falciparum." Thesis, Harvard University, 2012. http://dissertations.umi.com/gsas.harvard:10715.

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Malaria has plagued mankind for millennia. Antimalarial drug use over the last century has generated highly drug-resistant parasites, which amplify the burden of this disease and pose a serious obstacle to control efforts. This dissertation is motivated by the simple fact that malaria parasites have become resistant to nearly every antimalarial drug that has ever been used, yet the precise genetic mechanisms of parasite drug resistance remain largely unknown. Our work pairs genomics-age technologies with molecular biology, genetics and molecular epidemiology in order to identify and characteri

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31

McEuen, Scott Jacob. "The design and characterization of a microcalorimeter to aid drug discovery." Thesis, Massachusetts Institute of Technology, 2008. http://hdl.handle.net/1721.1/46060.

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Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2008.<br>Includes bibliographical references (leaves 61-62).<br>This thesis describes the design and characterization of a microcalorimeter used to aid drug discovery. There are four key functional requirements for the device: (1.) 8.4 [mu]J energy resolution, (2.) 20 [mu]L reactant volume (combined total), (3.) 10% experimental variance, and (4.) 100 [mu]K baseline calorimeter drift over a two hour period. The calorimeter utilizes a novel heat sensor. This heat sensor combines thermal expansion and the dyna

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32

Sandvik, Marianne. "Evaluation and characterization of calcium sulphate microneedles for rapid drug release." Thesis, Umeå universitet, Kemiska institutionen, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-101888.

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33

Boateng, Rita Afriyie. "In silico characterization of plasmodial transketolases as potential malaria drug target." Thesis, Rhodes University, 2018. http://hdl.handle.net/10962/63540.

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34

Wang, Lin. "Synthesis and Characterization of Functionalized Recombinant Thrombomodulin for Antithrombotic Drug Development." Cleveland State University / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=csu1441946591.

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35

Lu, Shan. "Characterization, Epigenetic Drug Effect, and Gene Delivery to Breast Cancer Cells." University of Akron / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=akron1447718189.

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36

Tian, Jingfei. "Synthesis and Characterization of Clickable Dendrimer Hydrogels for Ocular Drug Delivery." VCU Scholars Compass, 2014. http://scholarscompass.vcu.edu/etd/3395.

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Topical medication is a standard treatment for glaucoma. However, frequent dosing makes the therapy inconvenient and patient unfriendly. There is a great need to develop new topical formulations that provide long lasting noninvasive drug release. In this thesis, novel clickable dendrimer hydrogels for anti-glaucoma drug delivery were synthesized and characterized. Polyamidoamine (PAMAM) dendrimers have been widely applied for drug delivery. The physical characteristics they possess include monodispersity, water solubility, encapsulation ability, and a large number of surface groups. Polycation

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37

Bain, David F. "Development and characterization of biodegradable microspheres containing selected antimycobacterials." Thesis, Robert Gordon University, 1998. http://hdl.handle.net/10059/519.

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Prolonged therapy required to effectively treat mycobacterial infection frequently results in severe dose-limiting side-effects and drug resistance due to patient non-compliance with protracted dosage regimens. Biodegradable poly-a-hydroxy acid microspheres and microcapsules containing rifampicin (RIF) and isoniazid (INH) respectively have been prepared with the intention of providing high sustained site-specific concentrations to overcome some of the shortcomings of existing oral treatments. Due to the high dose, hydrophilicity and instability of both drugs, formulation strategies to attain h

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38

Sturm, Noé. "Characterization of natural product biological imprints for computer-aided drug design applications." Thesis, Strasbourg, 2015. http://www.theses.fr/2015STRAF059/document.

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La comparaison de site peut-elle vérifier l’hypothèse: «Les origines biosynthétiques des produits naturels leurs confèrent des activités biologiques»? Pour répondre à cette question, nous avons développé un outil modélisant les propriétés accessibles au solvant des sites de liaison. La méthode a montré des aspects intéressants, mais elle souffre d’une sensibilité aux coordonnées atomiques. Cependant, des méthodes existantes nous ont permis de prouver que l’hypothèse est valide pour la famille des flavonoïdes. Afin d’étendre l’étude, nous avons développé un procédé automatique capable de recher

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39

Heck, Marius [Verfasser]. "Preparation and characterization of drug-loaded (meth)acrylic intraocular lenses / Marius Heck." Berlin : Freie Universität Berlin, 2018. http://d-nb.info/1176705822/34.

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40

Dordunoo, Stephen Kwaku. "Characterization of drug-carrier systems for liquid filling of hard gelatin capsules." Thesis, Liverpool John Moores University, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.261411.

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41

Omar, Sabah Ahmed. "Drug-susceptibility and molecular characterization of epidemic and endemic malaria in Kenya." Thesis, London School of Hygiene and Tropical Medicine (University of London), 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.288639.

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42

Nahire, Rahul. "Development and Characterization of Multifunctional Nanoparticles for Drug Delivery to Cancer Cells." Diss., North Dakota State University, 2014. http://hdl.handle.net/10365/24788.

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43

Nilapwar, S. "Characterization and exploitation of protein ligand interactions for structure based drug design." Thesis, University College London (University of London), 2009. http://discovery.ucl.ac.uk/19034/.

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Most characterised protein-small molecule interactions that display a change in heat capacity (\bigtriangleupCp) occur with a negative \bigtriangleupCp value. This is often attributed to solvent reorganisation from reduction in solvent accessible apolar surface area accompanying complex formation. Positive \bigtriangleupCp values have not been widely reported and could typically be attributed to an increased solvent accessible apolar surface area, desolvation of polar surface area or structural transitions in the biomolecular complex. Heat shock protein-90 (Hsp90) is one of the abundant and im

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44

Vicatos, Alexios Ivan. "The preparation and characterization of multi-component systems in drug pre-formulation." Master's thesis, University of Cape Town, 2018. http://hdl.handle.net/11427/29504.

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The supramolecular derivatisation, via co-crystallization and cyclodextrin (CD) inclusion of three active pharmaceutical ingredients (APIs), was attempted with the aim of generating new solid forms with potential pharmaceutical application. The APIs under investigation included allopurinol (used for the treatment of gout and kidney stones), 6-thioguanine (used to treat acute myelogenous leukaemia) and valproic acid (for treatment of epilepsy and bipolar disorders). Allopurinol and 6-thioguanine were fairly intractable, yielding very limited results following co-crystallization trials with a se

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45

Plotkowski, Megan Lynn. "Characterization and modulation of transmembrane domain interactions in membrane protein drug-targets." Diss., Restricted to subscribing institutions, 2008. http://proquest.umi.com/pqdweb?did=1666392021&sid=2&Fmt=2&clientId=1564&RQT=309&VName=PQD.

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46

Parshad, Henrik. "Design of poorly soluble drug salts : pharmaceutical chemical characterization of organic salts /." [Cph.] : Department of Pharmaceutics, The Danish University of Pharmaceutical Sciences, 2003. http://www.dfh.dk/phd/defences/henrikparshad.htm.

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47

Sturm, Noe Joseph. "Characterization of Natural Product Biological Imprints for Computer-aided Drug Design Applications." Thesis, Griffith University, 2016. http://hdl.handle.net/10072/367893.

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Can computational binding site similarity tools verify the hypothesis: “Biosynthetic moldings give potent biological activities to natural products”? To answer this question, we designed a tool modeling binding site properties according to solvent exposure. The method showed interesting characteristics but suffers from sensitivity to atomic coordinates. However, existing methods have delivered evidence that the hypothesis was valid for the flavonoid chemical class. In order to extend the study, we designed an automated pipeline capable of searching natural product biosynthetic enzyme structure

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48

Lúðvíksdóttir, Hildur. "Production and characterization of LSD1 and LSD2 for fragment based drug discovery." Thesis, Uppsala universitet, Biokemi, 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-392958.

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49

Leekumjorn, Sukit. "Synthesis and Characterization of Potential Drug Delivery Systems using Nonionic Surfactant “Niosome”." Scholar Commons, 2004. https://scholarcommons.usf.edu/etd/1127.

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Niosomes are synthetic microscopic vesicles consisting of an aqueous core enclosed in a bilayer consisting of cholesterol and one or more nonionic surfactants. They are made of biocompatible, biodegradable, non-toxic, non-immunogenic and non-carcinogenic agents which form closed spherical structures (self assembly vesicles) upon hydration. With high resistance to hydrolytic degradation, niosomes are capable of entrapping many kinds of soluble drugs while exhibiting greater vesicle stability and longer shelf life. In this work, a potential drug delivery system has been designed, synthesized and

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50

Fiandaca, Maggie. "Ionic Liquid Formation and Characterization of a Non-steroid Anti-inflammatory Drug." Thesis, University of the Sciences in Philadelphia, 2020. http://pqdtopen.proquest.com/#viewpdf?dispub=22620871.

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The present work focuses on modifying a non-steroid anti-inflammatory drug (NSAID) into an ionic liquid and evaluating the resulting thermal behavior and structural changes of the drug. Naproxen was chosen as the NSAID molecule due to thermal stability and limited examples of its use as an ionic liquid in current literature. Lidocaine was chosen as the counterion based on a screening study of potential ionic liquid formers. The screening included both potential protic and aprotic formation and counterions were included with consideration to pKa, hydrogen bonding ability, molecular size, diffus

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