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Rozprawy doktorskie na temat „Chemistry and Biology”

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Data publikacji: 3 czerwca 2025

Data aktualizacji: 31 lipca 2025

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1

Dinescu, Adriana Cundari Thomas R. "Metals in chemistry and biology computational chemistry studies /." [Denton, Tex.] : University of North Texas, 2007. http://digital.library.unt.edu/permalink/meta-dc-3678.

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Dinescu, Adriana. "Metals in Chemistry and Biology: Computational Chemistry Studies." Thesis, University of North Texas, 2007. https://digital.library.unt.edu/ark:/67531/metadc3678/.

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Numerous enzymatic reactions are controlled by the chemistry of metallic ions. This dissertation investigates the electronic properties of three transition metal (copper, chromium, and nickel) complexes and describes modeling studies performed on glutathione synthetase. (1) Copper nitrene complexes were computationally characterized, as these complexes have yet to be experimentally isolated. (2) Multireference calculations were carried out on a symmetric C2v chromium dimer derived from the crystal structure of the [(tBu3SiO)Cr(µ-OSitBu3)]2 complex. (3) The T-shaped geometry of a three-coordina

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3

Yusop, Rahimi Muhammad. "Palladium chemistry in chemical biology." Thesis, University of Edinburgh, 2011. http://hdl.handle.net/1842/5734.

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A range of fluorescein derivatives were synthesised via Pd0-mediated cross-coupling chemistry of the mono triflate of fluorescein with a variety of boronic acids and the optical properties of each dye was studied. Among these derivatives, a new multicolour pH–dependant anthofluorescein which was highly sensitive to pH changes and viscosity changes was identified. Work was carried out to explore intracellular catalysis based on the immobilisation of Pd0 nanoparticles on microspheres. The entrapped Pd0 nanoparticles were rapidly taken up by cells, stay harmlessly within the cytoplasm for days an

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4

Laos, Roberto, and Steven A. Benner. "Linking chemistry and biology: protein sequences." Revista de Química, 2016. http://repositorio.pucp.edu.pe/index/handle/123456789/99314.

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En los últimos veinte años el número de genomas completos que han sido secuenciados y depositados en bancos de datos ha crecido dramáticamente. Esta abundancia de información de secuencias ha servido de base para la creación de una disciplina llamada paleogenética. En este artículo, sin ahondar en algoritmos complejos, presentamos algunos conceptos clave para comprender cómo las proteínas han evolucionado con el tiempo. Luego ilustraremos como la paleogenética es utilizada en biotecnología. Estos ejemplos resaltan la conexión entre la química y la biología, dos disciplinas que quizás veinte a

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5

Kay, C. W. M. "Magnetic field effects in chemistry and biology." Thesis, University of Oxford, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.334813.

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6

Tailor, Radha. "DNA triplexes in chemistry, biology and medicine." Thesis, University of Southampton, 2011. https://eprints.soton.ac.uk/192831/.

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The formation of DNA triple helices offers the possibility of selectively targeting specific genes to control their expression in vivo. This anti-gene strategy provides powerful tools for the development of therapeutics (anti-cancer drugs, drugs for viral infections) at the transcriptional level. DNA triplexes are formed when an oligonucleotide binds to the major groove of double helical DNA; the third strand can bind in either a parallel motif, or an anti-parallel motif. The requirement of low pH for the protonation of cytosine in the parallel binding motif makes the formation of triple helic

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7

Duran-Frigola, Miquel 1985. "Blending biology and chemistry to enable systems pharmacology." Doctoral thesis, Universitat Pompeu Fabra, 2016. http://hdl.handle.net/10803/459111.

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The avalanche of data that followed the sequencing of the human genome has revealed an overwhelming biological complexity. No simple molecular explanation exists for most of the diseases and, in consequence, simple therapies have low probability of success. The emerging field of systems pharmacology seeks drugs of broad impact on molecular networks. To achieve so, it is necessary to integrate heterogeneous data, at different levels of complexity, and find correlations between them. This translational exercise is, perhaps, the major concern of current biomedical research. In this Thesis we und

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8

Hioe, Johnny. "Theoretical investigations of radicals in biology and chemistry." Diss., Ludwig-Maximilians-Universität München, 2013. http://nbn-resolving.de/urn:nbn:de:bvb:19-163694.

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9

Tong, Wenyong. "Chemistry and biology of tumor-associated ganglioside GD2." Thesis, McGill University, 2012. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=107647.

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Effective therapies typically target diseased tissues without significantly affecting healthy tissues. A tumor-related glycosphingolipid (GSL), such as ganglioside GD2, distinguishes neuroectoderm tumors from their healthy counterparts and is a validated tumor target. GD2 is clinically targeted for diagnosis and immunotherapy. GD2 plays an important functional role in tumor progression and in chemoresistance. It also plays an important functional role in pain; however, the mechanisms that make GD2 important in such phenomena remain unknown.Thus, understanding the structure-activity relationshi

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10

Galveia, Luciano Paulo Rosa. "New tools for high throughput chemistry and biology." Thesis, University of Edinburgh, 2011. http://hdl.handle.net/1842/8374.

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New strategies for the high-throughput determination of protease substrate specificity using a dual colour microarray based format with a small library of FRET-based peptides were developed. Integral to this process was the development of an in-house hydrophobic microarray platform and the application of microarrays of microwells. Overall this allowed the rapid and quantitative analysis of a range of peptides with three proteases, subtilisin, chymopapain and thermolysin. An immobilised tetrafluoroarylsulfonyl chloride linker was developed to be used as a traceless linker for microwave-assisted

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11

Kimani, Flora, and Flora Kimani. "Triazabutadiene Chemistry in Organic Synthesis and Chemical Biology." Diss., The University of Arizona, 2016. http://hdl.handle.net/10150/620986.

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Triazabutadienes are nitrogen containing compounds with interesting acid-responsive behavior. These compounds are relatively stable, but once activated by an electrophile, for example through protonation, fall apart to yield diazonium and imine compounds. In general, diazonium compounds are unstable and require harsh methods of synthesis. Therefore, the use of triazabutadiene compounds as precursors to diazonium compounds, allows for a mild and more controlled access to this reactive moiety. This opens up diazonium chemistry to more complex chemical biology applications, as well as in the deve

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12

Srisa-Art, Monpichar. "Microdroplet reactors for high-throughput chemistry and biology." Thesis, Imperial College London, 2010. http://hdl.handle.net/10044/1/5592.

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Droplet-based microfluidic systems have recently been developed to overcome the problems of slow mixing and dispersion associated with traditional microfluidic systems. By utilising flow instabilities between two immiscible phases, droplets can be generated using normal microfluidic formats. Further, aqueous solutions can be confined and mixed within droplets, resulting in rapid homogenisation and no dispersion. Accordingly, droplet-based microfluidic systems have been utilised in various applications in a high-throughput manner. However, the techniques and methods for droplet formation, manip

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13

Nalbandian, Christopher John. "Catalytic Methods for Chemical Biology." Thesis, University of California, San Diego, 2018. http://pqdtopen.proquest.com/#viewpdf?dispub=10812166.

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<p> Inspired by atropisomerism and examples of differential biology displayed by enantiomeric compounds, I set out to develop a late stage regioselective functionalization of known kinase inhibitors that exhibit atropisomerism. The regioselective functionalization of these target atropisomeric scaffolds is pivotal in order to increase their barrier to rotation, rendering them isolable enantiomers. Chapter 1 explores the chemical methods developed in order to achieve this transformation. The mild late stage regioselective chlorination, and more broadly, halogenation of several diverse aromatics

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14

Blanchard, Jonathan. "Copper Toxicity and Accumulation: Physiology, Chemistry, and Molecular Biology." Scholarly Repository, 2009. http://scholarlyrepository.miami.edu/oa_dissertations/284.

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Our knowledge of aquatic Cu toxicity has increased greatly over the past several years culminating with the incorporation of a model (the Biotic Ligand Model (BLM)) into the regulatory framework which allows for the site specific adjustment of water quality criteria based on water chemistry. However, our understanding of Cu toxicity in the aquatic environment is limited mostly to freshwater (FW). Because of this limited knowledge, this dissertation set out to examine the affect of salinity on Cu toxicity and accumulation across salinities from FW to sea water (SW). First, this work examined

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15

Lee, Caroline Marian. "The chemistry and biology of novel gastrin/CCK peptides." Thesis, University of Liverpool, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.314536.

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16

Hazael, R. T. "High pressure studies in solid state chemistry and biology." Thesis, University College London (University of London), 2012. http://discovery.ucl.ac.uk/1346454/.

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The new family of multiferroic perovskites SeMO3 (M= Ni, Mn, Cu) are obtained under high-P,T synthesis conditions from mixtures of the oxides (NiO, MnO, SeO2 etc.) or the corresponding metal hydroxides at pressures between 2-7 GPa and at temperatures up to 1000°C. However, those syntheses can result in retention of the starting oxides in the reaction products, leading to difficulties in analysis of the magnetic properties. We have developed a precursor route based on the reaction of Na2SeO3 with anhydrous MCl2 compounds, leading to the formation of the crystalline perovskite material with form

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17

Woodward, J. R. "The effect of magnetic fields in chemistry and biology." Thesis, University of Oxford, 1997. http://ora.ox.ac.uk/objects/uuid:2a881ed6-77a9-4e5f-95de-9974ac9e18e7.

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This thesis is concerned with the effect of static and oscillatory magnetic fields on the yield of radical recombination reactions and the proposal that such effects may constitute a possible mechanism for the interaction of environmental electromagnetic fields with biological systems. A brief overview of research pertaining to the biological effects of environmental electromagnetic fields is presented. Next, the concept of the radical pair is introduced and the theory of its behaviour in solution is examined in order to illustrate the mechanism by which magnetic fields can affect its probabil

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18

Babino, Darwin O. "BIOLOGY AND CHEMISTRY OF CAROTENOID CLEAVAGE ENZYMES IN VISION." Case Western Reserve University School of Graduate Studies / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=case1448456428.

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19

Pathirana, Hema M. K. K. "Ligand chemistry of tellurium." Thesis, Aston University, 1985. http://publications.aston.ac.uk/14516/.

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20

Kramer, Daniel Joshua 1977. "Chemistry and biology of tricarbonyl complexes of technetium and rhenium." Thesis, Massachusetts Institute of Technology, 2003. http://hdl.handle.net/1721.1/29640.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemistry, 2003.<br>Last 29 leaves numbered "192." Vita.<br>Includes bibliographical references.<br>Chapter One: Two of the most famous tripodal ligands, Kliui's cyclopentadienyltris(dialkylphosphito)cobaltate(III) and Trofimenko's hydrotris(1-pyrazolyl)borate, were studied with respect to their reactivity towards Alberto's tris(solvento)tricarbonyltechnetium(I) and tris(solvento)tricarbonylrhenium(I) cations. The reaction of [M(H2O)3(CO)3]+ (M = Tc, Re) with Na[CpCo[PO(OR)2]3] (NaLOR; R = Me, Et) in water produced the compounds

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21

Cavero, Tomas Marta. "Aspects of thionitrites and nitric oxide in chemistry and biology." Thesis, University College London (University of London), 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.646020.

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22

Hinneburg, Detlef, and Nicole Mölders. "A mesoscale atmospheric model combining meteorology, chemistry, biology, and heterogeneity." Universitätsbibliothek Leipzig, 2016. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-213743.

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A mesoscale non-hydrostatic atmospheric model was extended by including both a chemical transport module (CTM) for the chemical triade NO, N02, and 0 3, and an explicit surface-subgrid module (ESSM) for a subscale resolution of the topographical surface. CTEM: The simulated time-dependent concentration fields result from the following processes involved: anthropogenic emission at different heights, biogenic emission, dry deposition on the receptive surface, chemical reactions, turbulent diffusion, and passive transport according to the model dynamics. The calculations in the lowest model layer

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23

Hinneburg, Detlef, and Nicole Mölders. "A mesoscale atmospheric model combining meteorology, chemistry, biology, and heterogeneity." Wissenschaftliche Mitteilungen des Leipziger Instituts für Meteorologie ; 12 = Meteorologische Arbeiten aus Leipzig ; 4 (1999), S. 44-58, 1999. https://ul.qucosa.de/id/qucosa%3A15094.

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A mesoscale non-hydrostatic atmospheric model was extended by including both a chemical transport module (CTM) for the chemical triade NO, N02, and 0 3, and an explicit surface-subgrid module (ESSM) for a subscale resolution of the topographical surface. CTEM: The simulated time-dependent concentration fields result from the following processes involved: anthropogenic emission at different heights, biogenic emission, dry deposition on the receptive surface, chemical reactions, turbulent diffusion, and passive transport according to the model dynamics. The calculations in the lowest model layer

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24

Fallah-Araghi, Ali. "Microdroplets as microreactors for biology and chemistry in microfluidic systems." Strasbourg, 2011. https://publication-theses.unistra.fr/restreint/theses_doctorat/2011/FALLAH-ARAGHI_Ali_2011.pdf.

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La compartimentation de la soupe primitive dans des vésicules est pensée comme étant une des premières étapes dans l’apparition de la vie. Ces compartiments primitifs permettent de lier une information génétique (génotype) avec les produits de son expression (phénotype). C’est une des premières étapes offrant la possibilité d’évolution et d’hérédité. En laboratoire l’évolution dirigée est basée sur les mêmes mécanismes de mutation et de sélection utilisés par l’évolution naturelle. Pour ce faire, le génotype et le phénotype sont couplés par une variété de méthodes, parmi les quelles la Compart

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25

Chalker, Justin M. "Reaction engineering for protein modification : tools for chemistry and biology." Thesis, University of Oxford, 2011. http://ora.ox.ac.uk/objects/uuid:52d92917-5c7f-4223-b554-2e1b4fc0b2ea.

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Chemical modification of proteins is critical for many areas of biochemistry and medicine. Several methods for site-selective protein modification are reported in this Thesis that are useful in accessing both natural and artificial protein architectures. Multiple, complementary methods for the conversion of cysteine to dehydroalanine are described. Dehydroalanine is used as a general precursor to several post-translational modifications and glycosylation, polyprenylation, phosphorylation, and lysine methylation and acetylation are all accessible. These modifications and their mimics were explo

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Chyan, Wen Ph D. Massachusetts Institute of Technology. "Targeted sensors for investigating mobile Zinc in biology." Thesis, Massachusetts Institute of Technology, 2013. http://hdl.handle.net/1721.1/82335.

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Thesis (S.B.)--Massachusetts Institute of Technology, Dept. of Chemistry, 2013.<br>Vita. Cataloged from PDF version of thesis.<br>Includes bibliographical references.<br>Chapter 1. Sensing Strategies for Detection of Mobile Zinc. Mobile zinc plays important physiological roles in areas such as the hippocampus, prostate, and pancreas. A better understanding of the distribution of intracellular mobile zinc could provide insight into the pathology of diseases including prostate cancer and Alzheimer's disease, both of which have been linked to abnormal mobile zinc levels. Accordingly, a palette of

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Sowell, Rena A. "Proteome measurements for developing hypotheses about the biology of Drosophila." [Bloomington, Ind.] : Indiana University, 2007. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3283100.

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Thesis (Ph. D.)--Indiana University, Dept. of Chemistry, 2007.<br>Source: Dissertation Abstracts International, Volume: 68-09, Section: B, page: 5918. Adviser: David E. Clemmer. Title from dissertation home page (viewed May 12, 2008).

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28

Maza, Johnathan Charles. "Expanding The Scope of Terminal Alkynes in Chemical Biology." W&M ScholarWorks, 2016. https://scholarworks.wm.edu/etd/1477068470.

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The terminal alkyne is one of the most widely used chemical moieties in chemical biology. Thanks to the relative absence of this functional group in biology, it has become a widespread functional handle for a plethora of biorthogonal chemistries. Our group has extended the scope of this functionality by developing a biological variant of the Glaser-Hay coupling, which brings together two terminal alkynes to form a diyne linkage. However, our initial findings revealed that the chemistry is plagued by protein degradation due to a deleterious copper(II) hydroxyl intermediate. Herein we extend the

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29

Rajarathinam, Kayathri. "Nutraceuticals based computational medicinal chemistry." Licentiate thesis, KTH, Teoretisk kemi och biologi, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-122681.

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In recent years, the edible biomedicinal products called nutraceuticals have been becoming more popular among the pharmaceutical industries and the consumers. In the process of developing nutraceuticals, in silico approaches play an important role in structural elucidation, receptor-ligand interactions, drug designing etc., that critically help the laboratory experiments to avoid biological and financial risk. In this thesis, three nutraceuticals possessing antimicrobial and anticancer activities have been studied. Firstly, a tertiary structure was elucidated for a coagulant protein (MO2.1) of

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Suárez, Marina Irene. "Exploring the synthesis of bio-polymers without biology." Thesis, University of Glasgow, 2018. http://theses.gla.ac.uk/30657/.

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For more than a century, chemists and biologists have been trying to understand, and recreate, how life originated on planet Earth. The exact origin of life will never be known, however, chemical pathways that could have contributed to the formation of the first living systems can be reconstructed. Prebiotic research, in general, has been based around the formation of precursors found in modern biology, and their self-organisation under very specific reaction environments. This approach has yet to yield a living system. One of the possible reasons for this failure is the adoption of separate r

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31

García, Serna Ricard. "Biochemoinformatics: integrative computational tools at the interface between chemistry and biology." Doctoral thesis, Universitat Pompeu Fabra, 2010. http://hdl.handle.net/10803/7225.

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The work on this thesis has focused on the development of integrated databases and visualization tools for three related areas of biomedical sciences involved in the drug discovery process. An annotated chemical library including drugs and other bioactive compounds with reported affinities over protein targets has been extended and optimized for its use in different knowledge based analysis and virtual profiling methodologies. A second database relating drugs with their side effects has also been developed in preparation for future studies. At the same time, two web based visualization archite

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32

Szarek, Mark Anthony. "Chemistry and biology of novel amino sugars and amino-sugar analogs." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp03/NQ31955.pdf.

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Casadonte, Donald Jay. "The Clarinet Reed: An Introduction to its Biology, Chemistry, and Physics." Connect to resource, 1995. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1210865836.

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Marsh, Benjamin J. "Synthetic chemistry and synthetic biology approaches to low oxidation state taxanes." Thesis, University of Nottingham, 2017. http://eprints.nottingham.ac.uk/41756/.

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This thesis details work towards the efficient production of low oxidation state taxanes either by synthetic biology or synthetic chemistry. With over 400 natural taxanes isolated to date, many low oxidation state taxanes have been eclipsed by the intense interest in Taxol®. Some of these low oxidation state taxanes have important medicinal properties, many are currently unexplored. Chapter I introduces the taxane family of natural products, their biosynthesis and biological activity. Chapter II documents our efforts to utilise synthetic biology to rapidly access low oxidation state taxanes. I

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35

Whelan, Helen A. "Calmodulin Dependent Protein Kinase II - A Sulfhydryl Chemistry Study /." The Ohio State University, 1995. http://rave.ohiolink.edu/etdc/view?acc_num=osu148793151262033.

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Runguphan, Weerawat. "Reprogramming alkaloid biosynthesis in Catharanthus roseus : synthetic biology in plants." Thesis, Massachusetts Institute of Technology, 2011. http://hdl.handle.net/1721.1/65274.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemistry, 2011.<br>Vita. Cataloged from PDF version of thesis.<br>Includes bibliographical references.<br>The medicinal plant Madagascar periwinkle (Catharanthus roseus) produces over 130 monoterpene indole alkaloid (MIA) natural products. Many of these compounds have pharmaceutical value, such as the anticancer agents vinblastine and vincristine. Unnatural modifications can impart novel bioactivity to the parent natural product. Advances in synthetic biology and microbial engineering have allowed overproduction of natural produ

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Allen, Peter M. (Peter Matthew). "Semiconductor nanocrystals : synthesis, mechanisms of formation, and applications in biology." Thesis, Massachusetts Institute of Technology, 2010. http://hdl.handle.net/1721.1/58464.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemistry, 2010.<br>"April 29, 2010." Vita. Cataloged from PDF version of thesis.<br>Includes bibliographical references.<br>The primary focus of this thesis is the synthesis and applications of semiconductor nanocrystals, or quantum dots (QDs). Novel synthetic routes to ternary 1-III-VI QDs are presented, and we report the first highly luminescent Cu-In-Se QDs spanning the red to near-infrared region. The synthetic method is modular and is extended to Ag-In-Se, Cu-In-Zn-S, and Ag-In-Zn-S QDs, luminescent from the blue to near-in

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McQuade, Lindsey Elizabeth 1981. "Turn-on fluorescent probes for detecting nitric oxide in biology." Thesis, Massachusetts Institute of Technology, 2010. http://hdl.handle.net/1721.1/57895.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemistry, 2010.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references.<br>Chapter 1. Investigating the Biological Roles of Nitric Oxide and Other Reactive Nitrogen Species Using Fluorescent Probes: This chapter presents an overview of recent progress in the field of reactive nitrogen species (RNS) sensing. Reactive nitrogen species, such as nitric oxide (NO) and its higher oxides, play important roles in cell signaling during many physiological and pathological events. Elucidation of the exact functions

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39

Tang, Xiaoting. "New analytical tools for systems biology." Online access for everyone, 2006. http://www.dissertations.wsu.edu/Dissertations/Fall2006/x_tang_081706.pdf.

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40

John, Karin. "Self-organization in biology and chemistry : molecular interactions in reaction diffusion systems /." Inhaltsverzeichnis, 2004. http://www.gbv.de/dms/ilmenau/toc/496549812john.PDF.

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41

Tomkins, Justin Mark. "The use of DNA as a molecular scaffold in chemistry and biology." Thesis, University of Cambridge, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.627128.

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42

Willrodt, Christian. "Synthetic biology for synthetic chemistry - Microbial production and selective functionalization of limonene." Doctoral thesis, Universitätsbibliothek Leipzig, 2016. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-201140.

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The progress in biotechnological disciplines such as metabolic engineering or synthetic biology increased the interest of chemical and pharmaceutical industries to implement microbial processes for chemical synthesis. However, most microorganisms, e.g., Escherichia coli or Saccharomyces cerevisiae, used in biotechnological applications are not evolved by nature for the production of industrially relevant compounds, which are often hydrophobic, non-charged, volatile, or toxic to the microbial organisms. Bioprocess design relies on an integrated approach addressing pathway, cellular, reaction, a

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Ayers, Benjamin James. "The synthesis and biology of iminosugars and their precursors." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:2441a224-0e6f-42e9-97d2-63dd3f6c49c3.

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Iminosugars are carbohydrate mimics, where the endocyclic ring oxygen has been replaced by nitrogen. This substitution affords these compounds their inhibitory activity towards sugar-processing enzymes (glycosidases) and, as a consequence, their chemotherapeutic potential in the treatment of a broad range of diseases. Several iminosugars are currently in clinical trials or have entered the market as approved drugs. This has consequently led to increasing levels of research into their synthesis and application, both in terms of the development of efficient methodology to access naturally occurr

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Hammarlund, Emma U. "Ocean chemistry and the evolution of multicellularity." Doctoral thesis, Stockholms universitet, Institutionen för geologiska vetenskaper, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-75466.

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Oxygen has been assumed to be a vital trigger for the evolution of multicellular life forms on Earth, partly based on its power to promote substantial energy flux in cell respiration and partly as biosynthesis of compounds like collagen require oxygen. However, the co-evolution of large life and the Earth’s chemical environment is not well understood at present, and there is particular disagreement in the field about whether the Cambrian explosion of animal life forms was a chemical or biological event. Here, I discuss the evolution of multicellularity, divided in simple or complex forms, in l

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Keiser, Michael James. "Relating protein pharmacology by ligand chemistry." Diss., Search in ProQuest Dissertations & Theses. UC Only, 2009. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3378494.

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Martell, Jeffrey Daniel. "Engineered heme peroxidases as genetically encoded probes with diverse applications in cell biology." Thesis, Massachusetts Institute of Technology, 2015. http://hdl.handle.net/1721.1/98787.

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Thesis: Ph. D., Massachusetts Institute of Technology, Department of Chemistry, 2015.<br>Vita. Cataloged from PDF version of thesis.<br>Includes bibliographical references.<br>Proteins perform myriad functions inside cells. In vitro studies of purified proteins yield important information about their function, but it is an important pursuit in cell biology to study proteins within the native context of intact cells, since their physiological functions might not be recapitulated in any other environment. The most basic question, the location of a protein within the cell, is difficult to answer,

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Daly, Aidan C. "Statistical tools and community resources for developing trusted models in biology and chemistry." Thesis, University of Oxford, 2017. https://ora.ox.ac.uk/objects/uuid:4e936e3b-7985-44f0-814c-7be3433bdcbb.

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Mathematical modeling has been instrumental to the development of natural sciences over the last half-century. Through iterated interactions between modeling and real-world exper- imentation, these models have furthered our understanding of the processes in biology and chemistry that they seek to represent. In certain application domains, such as the field of car- diac biology, communities of modelers with common interests have emerged, leading to the development of many models that attempt to explain the same or similar phenomena. As these communities have developed, however, reporting standa

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Hioe, Johnny [Verfasser], and Hendrik [Akademischer Betreuer] Zipse. "Theoretical investigations of radicals in biology and chemistry / Johnny Hioe. Betreuer: Hendrik Zipse." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2013. http://d-nb.info/1045561495/34.

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Huang, Hao Ph D. Massachusetts Institute of Technology. "Colloidal semiconductor nanocrystals as nanoscale emissive probes in light emitting diodes and cell biology." Thesis, Massachusetts Institute of Technology, 2008. http://hdl.handle.net/1721.1/43760.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemistry, 2008.<br>Vita.<br>Includes bibliographical references.<br>This thesis employs colloidal semiconductor nanocrystals (NCs) as nanoscale emissive probes to investigate the physics of light emitting diodes (LEDs), as well as to unveil properties of cells that conventional imaging techniques cannot reveal. On the LED side, in particular, Chapter 2 utilizes individual NCs to alter layered organic LED structures at nanometer scale, resulting in spectrally resolved electroluminescence from single colloidal CdSe/ZnS (core/shell

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Shim, Hyeseok. "Biology of Type 2 Phosphatidylinositol-5-Phosphate 4-Kinase." Thesis, Harvard University, 2015. http://nrs.harvard.edu/urn-3:HUL.InstRepos:23845419.

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Type 2 phosphatidylinositol-5-phosphate 4-kinase (PI5P4K) converts phosphatidylinositol-5-phosphate to phosphatidylinositol-4,5-bisphosphate. Mammals have three genes, PIP4K2A, PIP4K2B and PIP4K2C that encode the enzymes PI5P4Kα, PI5P4Kβ and PI5P4Kγ respectively. Studies in mice showed that PI5P4Kβ is a negative regulator of insulin signaling (Lamia et al., 2004) and that co-deletion of Pip4k2b and Trp53 resulted in synthetic embryonic lethality (Emerling et al., 2013). Also, deletion of two alleles of Pip4k2a and one allele of Pip4k2b suppressed the appearance of tumors in Trp53-/- mice. Thes

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