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Rozprawy doktorskie na temat „Chemokines”

Autor: Grafiati

Data publikacji: 4 czerwca 2021

Data aktualizacji: 25 lipca 2025

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1

Davis, Christopher Nathan. "Mammalian and viral chemokines provide insight into the mechanism of chemokine receptor activation." [Gainesville, Fla.] : University of Florida, 2004. http://purl.fcla.edu/fcla/etd/UFE0006481.

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2

Hua, Renyi. "The role of chemokines/chemokine receptors in labour." Thesis, Imperial College London, 2012. http://hdl.handle.net/10044/1/9847.

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Human labour is shown to be an inflammatory process, which involves a marked leukocyte infiltrate into myometrium during labour. My study focused on the role of chemokines, key mediators of leukocyte trafficking, in labour. Previous gene array data obtained from human labouring myometrium showed that the mRNA expression of the following chemokines was increased in term labouring myometrium, CCL2, CCL20, CXCL1, CXCL5, CXCL8. I decided to focus on myometrial expression of these chemokines and also to include CCL5, another important chemokine. My data confirmed that the expression of human myomet

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3

Wong, Jeffrey K. W. "Chemokines and chemokine receptors in islet xenograft rejection." Thesis, The University of Sydney, 2006. https://hdl.handle.net/2123/28055.

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This project investigates the role of chemokine and chemokine receptors in a model of CD4 T cell dependent cellular xenograft rejection, specifically the transplantation of fetal pig pancreas tissue to the renal subcapsular space of mice. Chemokines and chemokine receptor gene expression was assessed by cDNA arrays, and confirmed by multi-probe ribonuclease protection assay. Immunostaining for a selected chemokine, RANTES was performed to demonstrate upregulation at the protein level. These methods were applied to several different models to dissect the role Chemokines and their re

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4

Mowafi, Frida. "Chemokines and chemokine receptors during viral infections in man /." Stockholm : Karolinska institutet, 2007. http://diss.kib.ki.se/2007/978-91-7357-420-4/.

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5

Teleshova, Natalia. "Studies on co-stimulatory molecules, chemokines and chemokine receptors in neuroimmunological diseases /." Stockholm, 2001. http://diss.kib.ki.se/2001/91-628-4781-3/.

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6

Wang, Jixin. "Bioinformatic analysis of chicken chemokines, chemokine receptors, and Toll-like receptor 21." Texas A&M University, 2006. http://hdl.handle.net/1969.1/4212.

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Chemokines triggered by Toll-like receptors (TLRs) are small chemoattractant proteins, which mainly regulate leukocyte trafficking in inflammatory reactions via interaction with G protein-coupled receptors. Forty-two chemokines and 19 cognate receptors have been found in the human genome. Prior to this study, only 11 chicken chemokines and 7 receptors had been reported. The objectives of this study were to identify systematically chicken chemokines and their cognate receptor genes in the chicken genome and to annotate these genes and ligand-receptor binding by a comparative genomics approach.

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7

Maru, Seema V. "The role of chemokines and chemokine receptors in astrocytes and astrocytoma biology." Thesis, Open University, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.427496.

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8

Brozyna, Sheree. "The role of chemokines and chemokine receptors in chronic obstructive pulmonary disease (COPD) /." Title page and abstract only, 2005. http://web4.library.adelaide.edu.au/theses/09SB/09sbb8859.pdf.

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9

Simmons, Graham. "Human immunodeficiency syndrome virus type 1 cell tropism and inhibition by chemokines and chemokine analogues." Thesis, Institute of Cancer Research (University Of London), 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.368041.

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10

Juremalm, Mikael. "The Role of Chemokines in Mast Cell Migration." Doctoral thesis, Uppsala University, Department of Genetics and Pathology, 2003. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3273.

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<p>Mast cells are very potent multifunctional effector cells of the immune system normally distributed throughout connective tissues. An accumulation of mast cells has been described in several pathological conditions such as allergic- and autoimmune inflammations and in certain tumours. This necessitates two different processes: 1) Recruitment of mast cell progenitors from peripheral blood; 2) Accretion of mature mast cells at sites of inflammation and tumour areas. Both processes are depending on the local production of chemotactic factors. The aim of this study was to investigate the role o

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11

Thapa, Manoj. "Chemokines and chemokine receptors that mediate immune defense to genital herpes simplex virus type 2 (HSV-2) infection." Oklahoma City : [s.n.], 2008.

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12

Hughes, Simon Michael. "Molecular characterisation of avian chemokines." Thesis, University of Reading, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.394177.

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13

Lusti-Narasimhan, Manjula. "The molecular specificity of chemokines." Thesis, University of York, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.362019.

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14

Domingues, Catarina de Barros Pinto Salvador. "Chemokines impact in Alzheimer’s disease." Master's thesis, Universidade de Aveiro, 2015. http://hdl.handle.net/10773/16081.

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Mestrado em Biomedicina Molecular<br>Alzheimer’s Disease (AD) is a neurodegenerative disorder neuropathologically characterized by the presence of extracellular senile plaques, intracellular neurofibrillary tangles and synaptic loss. Neuroinflammation has been associated with some neurodegenerative diseases, such as AD. In AD, increased Aβ production and aggregation, have a fundamental role in the activation of the inflammatory process. In turn, this could be fundamental in the early stages of this pathology, regarding the Aβ clearance and brain protection. However, chronic inflammation leads

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15

Khan, Nouman Ullah. "The effect of chemokines on T regulatory cells following heart transplantation." Thesis, University of Manchester, 2011. https://www.research.manchester.ac.uk/portal/en/theses/the-effect-of-chemokines-on-t-regulatory-cellsfollowing-heart-transplantation(6b5b194d-f2fd-4869-9b22-95ce099ac3ed).html.

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Heart transplantation (HTx) is now an established therapy for end-stage cardiac failure not responding to medical treatment. Recent decades have seen improved outcome following HTx due to more effective and targeted immunosuppressive therapy. However, acute and chronic rejection remains a major cause of morbidity and mortality. At the same time, immunosuppressive strategies are associated with significant side effects, including development of tumours. Hence, the induction of immunologic tolerance to alloantigen is considered the “holy grail” of transplant research. T regulatory cells (Tregs)

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16

Kanazawa, Nobuo. "Fractalkine and macrophage-derived chemokine : T cell attracting chemokines expressed in T cell area dendritic cells." Kyoto University, 2000. http://hdl.handle.net/2433/180886.

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17

Negus, R. P. M. "Chemokines, leukocytes and human ovarian cancer." Thesis, Imperial College London, 1998. http://hdl.handle.net/10044/1/7211.

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18

McQuibban, Angus. "Matrix metalloproteinase processing of monocyte chemokines." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/NQ61145.pdf.

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19

Uddin, Jasim. "Chemokines and inflammatory responses in cysticercosis." Thesis, Imperial College London, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.407076.

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20

Kuschert, Gabriele Simone Viktoria. "Chemokines and their interaction with glycosaminoglycans." Thesis, University of York, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.298530.

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21

Franciszkiewicz, Katarzyna. "The role of chemokines and chemokine receptors in shaping the effector phase of anti-tumor immune response." Paris 7, 2010. http://www.theses.fr/2010PA077015.

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La réponse immunitaire antitumorale nécessite la mise en place de mécanismes effecteurs dépendant des lymphocytes T CD8+ cytotoxiques spécifiques. Cependant, leur présence n'est pas toujours suffisante pour induire une régression tumorale dépendant de plusieurs étapes: la migration des lymphocytes T au site tumoral, l'infiltration, l'établissement de contacts avec le cible cancéreuse et l'activation in situ. Les chimiokines sont impliquées dans la circulation des cellules immunocompétentes. Bien que leur rôle dans la progression tumorale soient bien établi, les chimiokines sont également respo

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22

Law, Yuet Ching. "Specific Compartmentalization of IgA ASCs in Mouse Salivary Glands via Differential Expression of Chemokines and Chemokine Receptors." BYU ScholarsArchive, 2008. https://scholarsarchive.byu.edu/etd/1952.

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The mucosal system, which forms a barrier between internal organ systems and the external environment, is frequently exposed to pathogenic microorganisms. Immunoglobulin A (IgA) antibody secreting cells (ASCs) localize in the lamina propria, and produce IgA antibodies which help protect mucosal tissues. The concept of a common mucosal immune system in which IgA ASCs have the ability to populate any mucosal site has been proposed (1, 2). However, recent research has suggested that IgA ASCs primed in different mucosal sites might possess different sets of chemokine receptors, and therefore migra

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23

Jin, Hongjun. "Structural and functional investigation of human chemokines and applications of human chemokines in blocking HIV-1 entry." [College Station, Tex. : Texas A&M University, 2007. http://hdl.handle.net/1969.1/ETD-TAMU-2430.

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24

Law, Yuet Ching. "Specific compartmentalization of Immunoglobulin A antibody secreting cells in mouse salivary glands via the differential expression of chemokines and chemokine receptors /." Diss., CLICK HERE for online access, 2008. http://contentdm.lib.byu.edu/ETD/image/etd2678.pdf.

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25

Timár, Krisztina Klára. "Human keratinocytes production of complement and chemokines /." [S.l. : Amsterdam : s.n.] ; Universiteit van Amsterdam [Host], 2006. http://dare.uva.nl/document/20321.

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26

Scotton, Christopher John. "Chemokines and their receptors in ovarian cancer." Thesis, University College London (University of London), 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.395391.

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27

McNaughton, Emily Francis. "Novel anti-inflammatory peptides based on chemokines." Thesis, University of Bristol, 2017. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.730839.

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28

Cunningham, Crystal. "Expression of Chemokines and VEGFs in HNSCC." VCU Scholars Compass, 2009. http://scholarscompass.vcu.edu/etd/1787.

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Head and neck squamous cell carcinoma (HNSCC) is the sixth most common malignancy worldwide. The 5-year survival rate when the cancer remains as a primary tumor is 81% but when it metastasizes to distant sites, defined as a metastatic cancer, it decreases dramatically to 26%. Approaches to prevent these cancers from undergoing these metastatic changes can greatly improve the survival and outcome of these cancer victims. This current study is examining the expression profiles of chemokines and VEGFs in HNSCC. By investigation the underlying pathways involved in the expressions of chemokines

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29

Edman, Linda C. "Chemokines and their role in dopaminergic development." Stockholm : Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 2009. http://diss.kib.ki.se/2009/978-91-7409-688-0/.

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30

Ridiandries, Anisyah. "The role of cc-chemokines in angiogenesis." Thesis, The University of Sydney, 2015. http://hdl.handle.net/2123/14951.

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Angiogenesis is a fundamental process in which new blood vessels are formed from pre-existing vessels. It is important in growth, development, and regeneration after injury. Inflammation causes an imbalance in the regulation of angiogenesis leading to unregulated pathological neovascularisation that exacerbates diseases such as cancer and atherosclerosis. Current anti-angiogenic therapies for the treatment of these diseases inhibit both pathological and physiological angiogenesis causing side effects such as hypertension, bleeding, severe weight loss, diarrhoea and nausea in a large percentage

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31

宋蘭。 and Lan Fion Sung. "Role of homocysteine in the expression of monocyte Chemoattractant protein-1 (MCP-1)." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1999. http://hub.hku.hk/bib/B31221658.

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32

Sung, Lan Fion. "Role of homocysteine in the expression of monocyte Chemoattractant protein-1 (MCP-1) /." Hong Kong : University of Hong Kong, 1999. http://sunzi.lib.hku.hk/hkuto/record.jsp?B21038338.

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33

Conrad, Sean Martin. "The influence of parasite-derived chemokines in Leishmaniasis." College Park, Md. : University of Maryland, 2006. http://hdl.handle.net/1903/4247.

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Thesis (Ph. D.) -- University of Maryland, College Park, 2006.<br>Thesis research directed by: Cell Biology & Molecular Genetics. Title from t.p. of PDF. Includes bibliographical references. Published by UMI Dissertation Services, Ann Arbor, Mich. Also available in paper.

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34

Poh, Tuang Yeow. "Functional characterization of avian chemokines and their receptors." Thesis, Imperial College London, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.441954.

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35

Darisipudi, Venkata Surya Narayana Murty. "Chemokines and cysteine proteases in diabetic kidney disease." Diss., Ludwig-Maximilians-Universität München, 2013. http://nbn-resolving.de/urn:nbn:de:bvb:19-173379.

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36

Kirkaldy, Alice Amanda. "The role of chemokines in leprosy skin lesions." Thesis, London School of Hygiene and Tropical Medicine (University of London), 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.268729.

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37

Marshall, Alison Shona. "The role of chemokines in oral lichen planus." Thesis, University College London (University of London), 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.413748.

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38

Lipfert, Jana. "Die Rolle und Funktionsweise der Chemokinrezeptoren CXCR4 und CXCR7 in Mikroglia und Astrozyten." Doctoral thesis, Universitätsbibliothek Leipzig, 2013. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-118858.

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Das Chemokin SDF-1 spielt eine wichtige Rolle bei der Hämatopoese, bei Immunreaktionen sowie bei der Entwicklung des Herzens, der Extremitätenmuskulatur und des zentralen und peripheren Nervensystems. Lange Zeit galt CXCR4 als der einzige Chemokinrezeptor für SDF-1, bis vor wenigen Jahren CXCR7 als ein alternativer Rezeptor für SDF-1 identifiziert wurde. Da alle Zelltypen des zentralen Nervensystems (ZNS) sensitiv für SDF-1 sind, sollte in dieser Arbeit die Funktion der beiden Rezeptoren in primärer Mikroglia und primären Astrozyten untersucht werden. Bisher konnte CXCR7 nur als Scavenger-Reze

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39

Dagkalis, Athanasios. "CCR2 and CX3CR1 in monocyte trafficking in experimental autoimmune uveoretinitis." Thesis, Available from the University of Aberdeen Library and Historic Collections Digital Resources, 2008. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?application=DIGITOOL-3&owner=resourcediscovery&custom_att_2=simple_viewer&pid=24809.

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40

Cavalcante, GalylÃia Menezes. "Study of expression of systems CXCR4-CXCL12/SDF-1, CCR7-CCL21 and Ki-67 in the oral squamous cell carcinoma and their association with clinicopathological factors,nodal metastases and survival." Universidade Federal do CearÃ, 2013. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=11989.

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Chemokines are responsible for the directed migration of leukocyte chemotactic cytokines, coordinating cell movement during inflammation and the transport of hematopoietic cells. In addition to leukocytes, chemokine receptors are also found in neoplastic cells and tumors associated with stromal cells. Among chemokines, and the CXCR4/CXCL12 CCR7/CCL21 systems have been shown the involvement of lymph node metastases or distant metastases in different cancers. Thus, aim of this study was to evaluate the expression of CXCR4, CXCL12, CCR7, CCL21 and Ki-67 in oral squamous cell carcinoma (SCC) and t

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41

Oladipo, O. "The clinical role of cxc-chemokines in colorectal cancer." Thesis, Queen's University Belfast, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.546403.

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42

Montero, Rosa Maria. "Chemokines and macrophage migration inhibitory factor in diabetic nephropathy." Thesis, Imperial College London, 2013. http://hdl.handle.net/10044/1/29851.

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Introduction: Diabetic nephropathy (DN) is the leading cause of end-stage renal disease in the Western world. Aim: To determine whether macrophage migration inhibitory factor (MIF), monocyte chemoattractant protein-1 (MCP-1) or CC chemokine ligand 18 (CCL18) have a causative role in the development of renal inflammation and fibrosis in DN and are useful biomarkers of disease progression. Methods: Urine and plasma samples were collected from 115 DM and 116 Non-DM at baseline, previously analysed for MCP-1 and CCL18 ELISA by Dr Qureshi. I measured MIF in these samples and collected 107 DM and 11

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43

Rosenblum, Joshua Michael. "Novel Roles for Chemokines in Acute Cardiac Allograft Rejection." Case Western Reserve University School of Graduate Studies / OhioLINK, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=case1244063137.

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44

Kwong, Amelia. "Crosstalk Between T Cells, Dendritic Cells, Cytokines, and Chemokines." Thesis, The University of Arizona, 2010. http://hdl.handle.net/10150/146198.

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T cells that came into contact with mature and immature dendritic cells had an overall reduction in gene expression in IL10, IL12, IL23, ICOS, TGFB, TNFA, PD1, TBET, GATA3, FASL, PERF, FOXP3, and CTLA4. T cells stimulated with immature dendritic cells had the most consistent results in decreasing gene expression in all the genes tested. T cells in contact with mature dendritic cells had mostly a decrease in gene expression, but in IFNG and Granzyme there was an increase in gene expression. However, when adding additional stimuli such as interferon(IFN) or hydroxychloroquine (HCQ) gene expressi

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45

Lin, Michelle. "Facilitation of neutrophil migration through the corneal stroma during keratitis-Mmp8 and chemokines." Connect to text online, 2007. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=case1191012168.

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46

Yu, Tian. "Role of atypical chemokine receptor-2 in ocular inflammation." Thesis, University of Aberdeen, 2015. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=229021.

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The atypical chemokine receptor-2 (ACKR2) is a chemokine decoy receptor that recognises pro-inflammatory CC chemokines. Many studies showed up-regulated inflammation and delayed resolution of inflammatory responses in ACKR2-/- mice. Furthermore, in the absence of ACKR2, lymphatic endothelial cells (LEC) fail to regulate the expression of pro-inflammatory CC chemokines leading to the excessive peri-lymphatic accumulation of leukocytes. As a result, the migration of antigen presenting cells (APC) through lymphatic vessels may be impaired due to lymphatic congestion. In addition, ACKR2 was shown

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47

Caronni, N. "ROLE OF CCL2 AND ITS RECEPTORS CCR2 AND D6 IN THE ACTIVATION AND POLARIZATION OF TUMOR-ASSOCIATED MACROPHAGES." Doctoral thesis, Università degli Studi di Milano, 2014. http://hdl.handle.net/2434/229564.

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Chemokines are well known to play a major role in tumor progression and metastasis. In particular CCL2 is over-expressed in several human cancers and their higher levels correlate with poor prognosis and shorter outcomes. Here we reported two different studies in which CCL2 receptors, the canonical CCR2 and the atypical D6 (or ACKR2) were examined for their involvement in tumor progression. In particular D6 was investigated for its expression and its ability to shape CCL2 gradient in Kaposi’s sarcoma, whereas CCR2 has been analyzed as potential modeler of TAM polarization. D6 is an atypical ch

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48

Sayyed, Sufyan G. "Role of pro-inflammatory and homeostatic chemokines in diabetic nephropathy." Diss., lmu, 2010. http://d-nb.info/1001123050/34.

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49

Bradford, Eric, Sean Jacobson, Jason Varasteh, et al. "The value of blood cytokines and chemokines in assessing COPD." BIOMED CENTRAL LTD, 2017. http://hdl.handle.net/10150/626086.

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Background: Blood biomarkers are increasingly used to stratify high risk chronic obstructive pulmonary disease (COPD) patients; however, there are fewer studies that have investigated multiple biomarkers and replicated in multiple large well-characterized cohorts of susceptible current and former smokers. Methods: We used two MSD multiplex panels to measure 9 cytokines and chemokines in 2123 subjects from COPDGene and 1117 subjects from SPIROMICS. These biomarkers included: interleukin (IL)-2, IL-6, IL-8, IL-10, tumor necrosis factor (TNF)-alpha, interferon (IFN)-gamma, eotaxin/CCL-11, eotaxin

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50

Ramwell, Andrew P. "The Role of Chemokines and their Receptors in Colorectal Cancer." Thesis, Imperial College London, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.511887.

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