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Rozprawy doktorskie na temat „Chemotherapy”

Autor: Grafiati

Data publikacji: 4 czerwca 2021

Data aktualizacji: 25 lipca 2025

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1

McGrath, Pamela. "Chemotherapy : Treatment Experimentation or Illusion? : a Study into the Bioethics of Chemotherapy." Thesis, Queensland University of Technology, 1993.

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The use of cytotoxic drugs, Chemotherapy, is considered by many a valid modality in the treatment of cancer. The use of this modality in the 1950's and 1960's led to considerable success in the treatment of a number of incurable and quickly lethal rare cancers. This gave rise in the 1970's to a high expectation that Chemotherapy would provide a much needed breakthrough in the search for a cure for cancer. This optimism has led to a significant extension of the modality beyond the above known limits of successful use and created a climate which strongly supports this experimental application,

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2

Mulholland, K. C. "Experimental chemotherapy-induced mucositis." Thesis, Queen's University Belfast, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.479433.

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Bates, Robert W. "Prodrugs for cancer chemotherapy." Thesis, University of Oxford, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.333294.

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4

Morris, D. L. "Chemotherapy of hydatid disease." Thesis, University of Nottingham, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.374320.

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5

Taylor, Duncan Hugh. "Chemotherapy of Echinococcus species." Thesis, University of Nottingham, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.252947.

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6

Lindner, Oana. "Chemotherapy-induced cognitive changes." Thesis, University of Manchester, 2015. https://www.research.manchester.ac.uk/portal/en/theses/chemotherapyinduced-cognitive-changes(48ea95ea-4510-41b6-850e-72e733747c7c).html.

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The present thesis, entitled Chemotherapy-induced cognitive changes, is being submitted in the alternative format, by Oana Calina Lindner to The University of Manchester for the degree of Doctor of Philosophy in the Faculty of Medical and Human Sciences, School of Psychological Sciences. The thesis consists of five empirical studies, written in article formats and three connecting chapters. The General introduction in Chapter 1, places the thesis in the context of late effects research in cancer survivors. I describe the prevalence of physical and emotional late effects, before going into more

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7

Tintoré, Gazulla Maria. "hAGT inhibitors as chemotherapy enhancers." Doctoral thesis, Universitat de Barcelona, 2015. http://hdl.handle.net/10803/299794.

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The O6-alkylguanine DNA alkyltransferase (hAGT or MGMT) is a DNA repair protein in charge of removing alkyl adducts from the O6 position of guanines, blocking their cytotoxic effects and playing an important role as a resistance mechanism to chemotherapy in cancer patients. For these reasons, it is considered relevant as a prognosis marker of cancer and represents a potential therapeutic target. Intense research efforts have been devoted to the identification of small molecules capable of inhibiting hAGT activity and enhancing the cytotoxic effect of the alkylating agents in tumour cells. I

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8

Prytz, Anna, and Linda Harnfeldt. "Chemotherapy and Cancer - childrens experiences." Thesis, Kristianstad University College, Department of Health Sciences, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:hkr:diva-3754.

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<p>With good knowledge about the disease and the treatment, the fear and worry of children and parents can be reduced. Children may be helped by painting to express their experiences. In order to have a good care, the care-personnel need to see and understand what the children need. It is important to live an as regular life as possible during the disease and its treatment. The aim of this study was to elucidate how children experience chemotherapy in conection with their cancer disease. The method that was chosen was an systematic literature review. The result was based on five qualitative ar

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9

Fallon, Padraic G. "Experimental chemotherapy of Schistosoma mansoni." Thesis, Bangor University, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.240017.

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10

Sujendran, Vijay. "Neoadjuvant chemotherapy in oesophageal cancer." Thesis, University of East Anglia, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.501118.

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Neoadjuvant chemotherapy in oesophageal cancer has gained rapid favour in le United Kingdom over the past few years. It remains controversial outside the UK, with mixed results from clinical trials. The work in this thesis begins with a review of the literature on neoadjuvant chemotherapy, and of the antimetabolites and platinum agents used. The quantitative reverse transcriptase polymerase chain reaction (qRTPCR) used to identify molecular determinants of chemosensitivity is discussed followed by a look at the clinical experience of neoadjuvant chemotherapy at a single centre. Over the past s

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11

Schirm, Sibylle, Christoph Engel, Markus Löffler, and Markus Scholz. "Modelling chemotherapy effects on granulopoiesis." Universitätsbibliothek Leipzig, 2015. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-159100.

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Background: Although the growth-factor G-CSF is widely used to prevent granulotoxic side effects of cytotoxic chemotherapies, its optimal use is still unknown since treatment outcome depends on many parameters such as dosing and timing of chemotherapies, pharmaceutical derivative of G-CSF used and individual risk factors. We showed in the past that a pharmacokinetic and dynamic model of G-CSF and human granulopoiesis can be used to predict the performance of yet untested G-CSF schedules. However, only a single chemotherapy was considered so far. In the present paper, we propose a comprehensive

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12

Owolabi, Olusegun Amoo. "Studies on chemotherapy of trypanosomes." Thesis, University of Salford, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.293826.

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13

Miles, Philip James. "Metal complexes for cancer chemotherapy." Thesis, University of Manchester, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.627992.

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14

Schirm, Sibylle, Christoph Engel, Markus Löffler, and Markus Scholz. "Modelling chemotherapy effects on granulopoiesis." BioMed Central, 2014. https://ul.qucosa.de/id/qucosa%3A12034.

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Background: Although the growth-factor G-CSF is widely used to prevent granulotoxic side effects of cytotoxic chemotherapies, its optimal use is still unknown since treatment outcome depends on many parameters such as dosing and timing of chemotherapies, pharmaceutical derivative of G-CSF used and individual risk factors. We showed in the past that a pharmacokinetic and dynamic model of G-CSF and human granulopoiesis can be used to predict the performance of yet untested G-CSF schedules. However, only a single chemotherapy was considered so far. In the present paper, we propose a comprehensive

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15

Vincent, Jacob Adam. "Sensorimotor Deficits Following Oxaliplatin Chemotherapy." Wright State University / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=wright1496136263522854.

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16

Taylor, W. B. "Control of emesis in cancer chemotherapy." Thesis, University of Newcastle upon Tyne, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.378877.

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17

Nani, Frank Kofi. "Mathematical models of chemotherapy and immunotherapy." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape15/PQDD_0012/NQ34816.pdf.

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18

Petchey, M. "Lens carbohydrate metabolism and cataract chemotherapy." Thesis, University of Oxford, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.371562.

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19

Mellor, C. M. "Immunomodulation and chemotherapy of parasitic infections." Thesis, University of Nottingham, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.378990.

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20

Luo, Tian. "PEGylation of paclitaxel for inhaled chemotherapy." Thesis, University of Nottingham, 2016. http://eprints.nottingham.ac.uk/35723/.

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Pulmonary delivery offers an attractive route for delivering chemotherapeutics, with the benefits of high drug concentrations locally and low side effects systemically. However, fast clearance of small molecules in the lungs and the pulmonary toxicity are the main obstacles in this field. In this thesis, we explored the utility of polyethylene glycol-paclitaxel (PEG-PTX) conjugates to achieve sustained drug release in the lungs. Paclitaxel was linked to 6 kDa and 20 kDa PEG and the conjugates showed good stability and cytotoxicity in vitro. PEG-PTX largely increased the maximum tolerated dose

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21

Sutterfield, Shelbi Lorrae. "Microvascular function in patients undergoing chemotherapy." Thesis, Kansas State University, 2017. http://hdl.handle.net/2097/38216.

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Master of Science<br>Department of Kinesiology<br>Carl Ade<br>Adjuvant systemic chemotherapy for the treatment of certain cancers, particularly breast and lymphoma, adversely impacts cardiovascular health. However, the extent to which it impairs endothelial function is not well understood. Therefore, the purpose of this study was to determine if microvascular and macrovascular endothelial-dependent vasoreactivity is attenuated in breast cancer and lymphoma patients currently being treated with chemotherapy compared to healthy counterparts. With laser Doppler imaging, cutaneous microvascular fu

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22

Athawale, Samita. "Chemotherapy Appointment Scheduling and Operations Planning." University of Akron / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=akron1428951061.

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23

Barnes, Andrew C. "Control of furunculosis by antimicrobial chemotherapy." Thesis, University of Edinburgh, 1993. http://hdl.handle.net/1842/19915.

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<i>In vitro</i> ativities of six fluoroquinolone antimicrobials, flumequine, sarafloxacin, PD127,391, PD117,596, enrofloxacin and Ro 09-1690, against <i>Aeromonas salmonicida</i>, isolated from outbreaks of furunculosis in farmed and wild Atlantic salmon (<i>salmo salar</i>), were evaluated in terms of minimum inhibitory concentration (MIC), bactericidal activity and the frequency at which mutation to resistance developed to the drugs compared to oxolinic acid, the 4-quinolone antibiotic currently licensed for furunculosis therapy in the UK. MICs were also determined for oxytetracycline and th

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24

Wong, Ka Yeung Mark. "Drug clearance mechanisms and chemotherapy response." Thesis, The University of Sydney, 2007. https://hdl.handle.net/2123/28094.

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Cytotoxic chemotherapeutic agents have a major role in the treatment of cancers. However, many cytotoxic agents have a narrow therapeutic window with best treatment response achieved only within a small range of drug concentrations.

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25

Clark, Calum. "Scheduling chemotherapy appointments : a heuristic approach." Thesis, University of Leeds, 2010. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.538443.

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26

Bossaer, John B. "Thyroid Dysfunction with Targeted Chemotherapy Agents." Digital Commons @ East Tennessee State University, 2012. https://dc.etsu.edu/etsu-works/2361.

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1. Evaluate the mechanisms by which hyperglycemia and hypothyroidism occur in patients on certain targeted chemotherapy agents.2. Develop treatment recommendations for patients who develop these endocrine toxicities while on therapy.3. Establish appropriate monitoring guidelines for patient receiving certain targeted chemotherapy agents.

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27

AlEjielat, Rowan Fahad Ibrahim. "Pharmacogenomics of chemotherapy induced cognitive dysfunction." Diss., University of Iowa, 2013. https://ir.uiowa.edu/etd/1528.

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Cognitive decline is increasingly recognized as a side effect of chemotherapy. However, cognitive decline doesn't occur in all patients receiving chemotherapy, and there is variability in the cognitive domains affected (Ahles; JCO,Oct 20, 2012:3675-3686). Safety pharmacogenomics, i.e. using genetic variations to predict response/toxicity, offers an exciting approach to identify the subset of patients most likely to suffer from cognitive decline post chemotherapy. Consequently specific therapeutic interventions can be developed to target this group of patients, and/or alternate chemotherapeutic

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28

Alkhlaif, Yasmin. "IMPACT OF CHEMOTHERAPY ON NICOTINE DEPENDENCE." VCU Scholars Compass, 2017. https://scholarscompass.vcu.edu/etd/5175.

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Although cigarette smoke has been implicated in a causal relationship with various types of cancers, around 62% of all cancer patients are current smokers, recent quitters, or former smokers. While most patients who are smokers are motivated to quit after cancer diagnosis, 25 -30% of these patients continue to smoke. Furthermore, most quitters relapse after 2-3 years of post-chemotherapy. This represents a major health concern since several clinical studies revealed that perpetuation of smoking in cancer populations attenuates patient's well-being and quality of life. Smoking may impair healin

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29

Pink, Daniel, Stephan Richter, Sebastian Gerdes, et al. "Gemcitabine and Docetaxel for Epithelioid Sarcoma: Results from a Retrospective, Multi-Institutional Analysis." Karger, 2014. https://tud.qucosa.de/id/qucosa%3A70562.

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Objective: Epithelioid sarcoma (ES) presents unique clinical features in comparison to other sarcoma subtypes. Data regarding the benefits of chemotherapy are very limited. Combination regimens using gemcitabine and docetaxel (Gem/Doce) have proven to be effective, especially in uterine and nonuterine leiomyosarcoma. Yet, there is no available data on the efficacy of Gem/Doce in ES. Methods: A retrospective analysis of the three participating institutions was performed. Twenty-eight patients with an ES diagnosis presented at one of the participating institutions between 1989 and 2012. Of this

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30

Scherling, Carole Susan. "What Happens Before Chemotherapy?! Neuro-anatomical and -functional MRI Investigations of the Pre-chemotherapy Breast Cancer Brain." Thèse, Université d'Ottawa / University of Ottawa, 2011. http://hdl.handle.net/10393/20398.

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The side-effects of chemotherapy treatment are an increasingly important research focus as more cancer patients are reaching survivorship. While treatment allows for survival, it can also lead to problems which can significantly affect quality of life. Cognitive impairments after chemotherapy treatment are one such factor. First presented as anecdotal patient reports, over the last decade empirical evidence for this cognitive concern has been obtained. Much attention has been focused on post-chemotherapy research, yet little attention has been granted to these same patients’ cognition befor

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31

Redzepovic, Jasmina [Verfasser]. "Meta-analysis in context : Chemotherapy versus chemotherapy combined with bisphosphonate therapy in multiple myeloma patients / Jasmina Redzepovic." Berlin : Freie Universität Berlin, 2009. http://d-nb.info/1023664585/34.

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32

MACAIONE, Ina. "Intraperitoneal chemotherapy versus adjuvant chemotherapy for treatment of colo-rectal cancer at high-risk for peritoneal carcinosis." Doctoral thesis, Università degli Studi di Palermo, 2021. http://hdl.handle.net/10447/506907.

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33

Irving, Glen Robert Bell. "A novel approach to enhancing the effectiveness of chemotherapy : combining curcumin with FOLFOX chemotherapy for metastatic colorectal cancer." Thesis, University of Leicester, 2014. http://hdl.handle.net/2381/35981.

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FOLFOX (5FU/leucovorin/oxaliplatin) is standard first-line therapy for metastatic colorectal cancer (mCRC), with response rates of 50%. Factors limiting the use of oxaliplatin include chemo-resistance and severe dose-related peripheral neuropathy. New interventional strategies are required which can improve disease outcomes by increasing drug efficacy whilst avoiding toxicity. Curcumin is a constituent of turmeric. Mechanisms of chemopreventive action, extensively investigated in vitro and in vivo, provide compelling evidence that curcumin exhibits efficacy in preventing neoplastic conditions

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34

Clutter, Suzanne Davis. "Chemotherapy disrupts bone marrow stromal cell function." Morgantown, W. Va. : [West Virginia University Libraries], 2006. https://eidr.wvu.edu/etd/documentdata.eTD?documentid=4528.

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Thesis (Ph. D.)--West Virginia University, 2006.<br>Title from document title page. Document formatted into pages; contains x, 180 p. : ill. (some col.). Vita. Includes abstract. Includes bibliographical references.

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35

Palle, Josefine. "Optimizing Chemotherapy in Childhood Acute Myeloid Leukemia." Doctoral thesis, Uppsala University, Department of Women's and Children's Health, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-9189.

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<p>Despite major advances in our understanding of the biology of childhood acute myeloid leukemia (AML) and the development of new cytotoxic drugs, the prognosis of long-term survival is still only 60-65 %.</p><p>In the present research, we studied the pharmacokinetics of drugs used in the induction therapy of childhood AML and performed in vitro drug sensitivity testing of leukemic cells from children with AML.</p><p>The aims of the studies were to correlate the results of the analysis to biological and clinical parameters and to identify subgroups of AML with specific drug sensitivity profil

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36

Smit, Egbert Frederik. "Aspects of palliative chemotherapy for lung cancer." [S.l. : [Groningen : s.n.] ; University Library Groningen] [Host], 1990. http://irs.ub.rug.nl/ppn/292220588.

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37

Masquelier, Michèle. "Leukemia chemotherapy : experimental studies on pharmacological optimisation /." Stockholm, 2004. http://diss.kib.ki.se/2004/91-7140-046-X/.

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38

Ruth, Serge van. "Hyperthermic intracavitary chemotherapy in abdomen and chest." [S.l. : Amsterdam : s.n.] ; Universiteit van Amsterdam [Host], 2003. http://dare.uva.nl/document/69072.

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39

Witkamp, Arjen Joost. "Hyperthermic intraperitoneal chemotherapy in peritoneal surface malignancy." [S.l. : Amsterdam : s.n.] ; Universiteit van Amsterdam [Host], 2003. http://dare.uva.nl/document/69091.

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40

Meerten, Esther van. "Chemotherapy and Chemoradiotherapy Studies in Oesophageal Cancer." [S.l.] : Rotterdam : [The Author] ; Erasmus University [Host], 2008. http://hdl.handle.net/1765/13209.

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41

Davies, Geraint Rhys. "Pharmacokinetics and pharmacodynamics of anti-tuberculosis chemotherapy." Thesis, University of Liverpool, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.502576.

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For the first time in thirty years the tuberculosis drug development pipeline may be on the verge of delivering ultra-short course chemotherapy but continued reliance on relapse rates in clinical trials and limited understanding ofthe phenomenon ofpersistence ofM tuberculosis during treatment have made the critical pathway of early clinical development uncertain. It is demonstrated here that serial sputum colony counting,prolonged throughout the first two months oftreatment and analysed using hierarchical non-linear regression techniques has the power to detect treatment differences between co

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42

Kaestner, Sabine Anna. "Studies on dose-banding of cancer chemotherapy." Thesis, University of Bath, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.438893.

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43

Richardson, Alison. "Patterns of fatigue in patients receiving chemotherapy." Thesis, King's College London (University of London), 1995. https://kclpure.kcl.ac.uk/portal/en/theses/patterns-of-fatigue-in-patients-receiving-chemotherapy(077d4a6d-4c32-4639-93aa-f442e4d1775f).html.

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44

Thomas, M. "STAT1 : a modulator of chemotherapy induced apoptosis." Thesis, Queen's University Belfast, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.426906.

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45

Al-Samarai, Abdul-Ghani M. Ali Hasani. "Chemotherapy of parasitic infection by Herpesvirus hominis." Thesis, University of Sheffield, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.318149.

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46

Shah, Iftikhar Ali. "Chemotherapy with activated charcoal adsorbed mitocycin-C." Thesis, University of Liverpool, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.275012.

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47

Vacchelli, Erika. "Immunogenetic determinants of chemotherapy response in cancer." Thesis, Paris 11, 2014. http://www.theses.fr/2014PA11T041.

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L’efficacité de la chimiothérapie contre la croissance tumourale repose sur l'induction d'une mort des cellules tumourales dite immunogène. Les cellules tumourales mourantes agissent alors comme un vaccin thérapeutique en stimulant une réponse immunitaire anti-tumourale capable de contrôler, voire d'éliminer, les cellules cancéreuses résiduel. Les trois marqueurs principales de la mort cellulaire immunogène (MCI), sont (i) l'exposition pré-apoptotique de la calréticuline (CRT) à la surface des cellules, (ii) la sécrétion de l'ATP pendant l'apoptose qui dépend du processus d'autophagie, et (iii

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48

Hanoteau, Aurélie. "Chemotherapy potentiates immune responses against murine tumors." Doctoral thesis, Universite Libre de Bruxelles, 2016. https://dipot.ulb.ac.be/dspace/bitstream/2013/231745/5/Thesis.pdf.

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There is increasing evidence that the effect of chemotherapy on tumor rejection is not cell autonomous but relies on the immune system. Indeed, several reports have shown that human and murine tumors respond to chemotherapeutic agents more efficiently when the host immune system is intact. In particular, we have shown that cyclophosphamide treatment of DBA/2 mice bearing P815 mastocytoma induces rejection and long term protection in a CD4- and CD8-dependent manner. We used this tumor model, as it is poorly immunogenic, expresses tumor-associated P1A and tumor-specific P1E antigens, encoded by

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49

Chen, Danny. "Approaches to improve efficacy of cancer chemotherapy /." The Ohio State University, 2002. http://rave.ohiolink.edu/etdc/view?acc_num=osu1486463321624467.

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Roca-Alonso, Laura. "MicroRNA implications in chemotherapy-induced cardiac toxicity." Thesis, Imperial College London, 2014. http://hdl.handle.net/10044/1/24960.

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The use of anthracyclines such as doxorubicin (DOX) has improved mortality and morbidity in cancer patients, yet associated risks of cardiomyopathy have limited their clinical application. DOX-associated cardiotoxicity typically progresses to heart failure (HF). The knowledge of the mechanisms underlying DOX-related cardiac dysfunction is currently limited, hampering the development of cardioprotective strategies. MicroRNAs (miRNAs) are gene expression regulators that play potent roles in both cardiovascular disease and cancer. We wished to investigate DOX-induced changes in cardiac miRNA expr

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