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Artykuły w czasopismach na temat „Chlorophyllipt”

Autor: Grafiati

Data publikacji: 3 czerwca 2025

Data aktualizacji: 31 lipca 2025

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1

Martynov, A.V., T.V. Bomko, T.N. Nosalskaya, and T.V. Kabluchko-Baruah. "STRUCTURES AND BIOLOGICAL ACTIVITY OF CUPROPHYLLINS." Annals of Mechnikov Institute, no. 2 (June 7, 2017): 7–14. https://doi.org/10.5281/zenodo.803832.

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Chlorophylls (a, b) are the porphyrin compounds and most common chemical in the plant’s world. In fact, these compounds are an obligatory intermediate product both in energy metabolism and in plant catabolism. At the same time, currently there are few pharmaceutical preparations on the pharmaceutical market based on chlorophylls. Dyes based on hydrolyzed chlorophyll are successfully used in the food industry. Commercial chlorophylline is a copper complex of hydrolyzed chlorophylls. As shown earlier in TLC, the chlorophyllin mixture contains a large number of different compounds. It is like wat

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2

Krasnopolsky, Yuriy, and Daria Pylypenko. "ENCAPSULATION OF EUCALYPTUS LEAVES PHYTOPRODUCTS INTO LIPOSOMAL NANOPARTICLES AND STUDY OF THEIR ANTIBACTERIAL ACTIVITY AGAINST STAPHYLOCOCCUS AUREUS IN VIVO." Journal of microbiology, biotechnology and food sciences 12, no. 5 (2023): e9445. http://dx.doi.org/10.55251/jmbfs.9445.

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Plant oils are high effective active pharmaceutical ingredients, but the extremely low bioavailability of lipophilic compounds limits their use in drugs. The encapsulation of essential oils into nanoparticles are actively studied. The aim of the research was to prepare liposomal forms of eucalyptus leaves extract and Chlorophyllipt and to study their antibacterial activity. Liposomal forms of Chlorophyllipt and eucalyptus oil extract was prepared using egg phosphatidylcholine and cholesterol by high pressure homogenization and sonication method. The average particle sizes of liposomal Chloroph

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3

Sachuk, R. M., Ya S. Stravsky, YU V. Horyuk, O. A. Katsaraba, and S. V. Zhyhalyuk. "Selection of the optimal composition of vegetable oil and chlorophyllipt oil components." Ukrainian Journal of Veterinary and Agricultural Sciences 2, no. 3 (2019): 11–14. http://dx.doi.org/10.32718/ujvas2-3.03.

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Investigate the antimicrobial properties of various concentrations of vegetable essential oils in combination with an oil solution of chlorophyllipt as possible ingredients for ointments for wounds. Microbiological tests were performed according to standard methods using E. coli test cultures, S. aureus, Str. agalactiae and P. fluorescens. The results of studies of antibacterial activity of both individual ingredients and their combinations are presented, namely: 4 % essential oil of Siberian pine, 2 % essential oil of eucalyptus, 1.5 % essential oil of cloves, 1.5 % of essential oil of cedar,

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4

Zub, A. A., T. V. Gayvoronskaya, A. Yu Muratova, and A. V. Arutyunov. "Clinical and Immunological Efficacy of an Eucalyptus Leaf Preparation in Chronic Periodontitis Treatment: A Randomized Interventional Longitudinal Clinical Study." Kuban Scientific Medical Bulletin 29, no. 6 (2022): 26–40. http://dx.doi.org/10.25207/1608-6228-2022-29-6-26-40.

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Background. The prevalence of inflammatory-destructive periodontal diseases remains to be a global problem. Long-term topical application of chlorhexidine bigluconate and metronidazole is known to involve various side effects, thereby requiring widening the spectrum of herbal preparations used for treating chronic periodontitis.Aim. To evaluate the efficacy of Chlorophyllipt in the treatment of chronic generalized periodontitis by studying cytokine concentration dynamics in the gingival fluid.Methods. A randomized controlled clinical study of outcomes achieved in 50 patients with chronic gener

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5

Faustova, M. O. "SENSITIVITY OF STREPTOCOCCUS PLURANIMALIUM CLINICAL ISOLATE TO ANTISEPTICS." Актуальні проблеми сучасної медицини: Вісник Української медичної стоматологічної академії 20, no. 2 (2020): 182–85. http://dx.doi.org/10.31718/2077-1096.20.2.182.

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Recent reports have stressed out a global increase in the identification of new pathogens, which are not characteristic for the human microbiota, as well as significant changes in the microbial composition of different biotopes of its body. The purpose of this study was to investigate the sensitivity of S. pluranimalium clinical isolate to antiseptics. Materials and methods. The clinical isolate of S. pluranimalium was taken from the patient's mouth. The isolation and cultivation of the microorganism was carried out by standard techniques. Final identification was performed using an automatic

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6

Pylypiv, Daryna B., Boris M. Sharga, Olexandr A. Rishko, Vitalii Leshak, and Elena Karbovanets. "Relation of Streptococcus Pyogenes tonsillitis isolate to antimicrobial agents and its infection treatment." Wiadomości Lekarskie 77, no. 1 (2024): 171–77. http://dx.doi.org/10.36740/wlek202401122.

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We reported the case of tonsillitis treatment in a 17-years-old boy with use of chemical non-antibiotic preparations, plant derived products and antibiotic benzathine phenoxymethylpenicillin. The antimicrobial agents for treatment were selected on the basis of their activity against a disease agent, the group A β-hemolytic strain Streptococcus pyogenes BS1 isolated from a patient. The bacterium was susceptible in vitro to β-lactams, with largest zones conditioned by penicillin G and benzathine phenoxymethylpenicillin discs, to fluoroquinolones and to cephems, with exception of cefazolin. Linco

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7

Vorobets, N. M., M. V. Kryvtsova, O. Y. Rivis, M. Y. Spivak, H. V. Yavorska, and H. M. Semenova. "Antimicrobial activity of phytoextracts on opportunistic oral bacteria, yeast and bacteria from probiotics." Regulatory Mechanisms in Biosystems 9, no. 3 (2018): 374–78. http://dx.doi.org/10.15421/021855.

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Developed experimental assays enable us to compare the antimicrobial activity of herbal medicinal drugs on Lactobacillus and Bacillus strains probiotics, which have been claimed to possess the ability of suppressing the growth of various oral pathogens. In the treatment of periodontal disease it is advisable to use a comprehensive approach which would include the application of herbal remedies and probiotics. The combination of such effects may be a new approach in dentistry due to their complementary antimicrobial activity. In this study, we researched antimicrobial effects of herbal medicina

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8

Bomko, T. V., A. V. Martynov, and T. N. Nosalskaya. "THE STUDY OF SOME PROMISING PHARMACEUTICAL COMPOSITIONS WITH UREASE INHIBITORY ACTIVITY FOR THE TUBERCULOSIS REACTIVATION PREVENTION." Annals of Mechnikov Institute, no. 4 (December 28, 2017): 43–45. https://doi.org/10.5281/zenodo.1133775.

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<strong>Introduction</strong>. The aim of the study was to study the ability to inhibit urease by some pharmaceutical compositions that are promising in the prevention of tuberculosis reactivation . In particular, according to a number references sources, quercetin is able to successfully inhibit urease by a non-competitive mechanism. Another compound - dipyrone (metamizol sodium) according to preliminary molecular modeling has a pharmacophore structure similar to urea. <strong>Materials and methods</strong>. The biochemical studies (urease activity) of some substances effect on urease was car

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9

Andreeva, Svetlana V., L. I. Bakhareva, D. Yu Nokhrin, M. V. Titova, N. E. Khaidarshina, and A. L. Burmistrova. "Susceptibility to antiseptic preparations in biofilm-forming Staphylococcus aureus and Pseudomonas aeruginosa isolated from burn wounds." Clinical Microbiology and Antimicrobial Chemotherapy 20, no. 3 (2018): 249–56. http://dx.doi.org/10.36488/cmac.2018.3.249-256.

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The article presents data on susceptibility to antiseptic preparations in antibiotic-resistant S. aureus and P. aeruginosa strains isolated from burn wounds, which were tested in single-species and double-species biofilms with varying degrees (24-hour and 48-hour) of maturity. The studies demonstrated susceptibility of S. aureus and P. aeruginosa in single- and double-species biofilms to “Prontosan”, “Betadine” and “Chlorophyllipt” and resistance to “Miramistin” and “Chlorhexidine”. The bactericidal effect was achieved at concentrations 1.64 times higher than bacteriostatic concentrations for

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10

Pivovarov, O. A., O. S. Kovalоva, and Ch V. Matsyuk. "Innovative grain germination stimulators of natural origin." Science, technologies, innovation, no. 4(24) (2022): 31–44. http://dx.doi.org/10.35668/2520-6524-2022-4-03.

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An important issue of the agro-technological sector of Ukraine is to find optimal conditions and resources for the germination of grains of various crops. Innovative technological factors are necessary for their rapid growth, stable transfer of changes in conditions, production of high-quality products for long-term storage. So, in order to obtain the necessary technological properties of germinated grain, it was researched and determined which natural germination stimulator best meets today’s requirements. Mung bean seeds were selected for germination; crushed eggshell, chlorophyllipt, calciu

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11

Burova, L., O. Korniychuk, S. Pavliy, and Y. Mazepa. "Comparative characteristics antimicrobial activity of different classes of antibiotics and antimicrobial isolates on Staphylococcus aureus." Reports of Vinnytsia National Medical University 24, no. 1 (2020): 12–16. http://dx.doi.org/10.31393/reports-vnmedical-2020-24(1)-02.

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Annotation. S. aureus is a leading cause of nosocomial infections in health care facilities. The aim of the study was to determine the effectiveness of the use of staphylococcal bacteriophage, phytopreparation “Chlorophyllipt”, of the drug “Protargol”, compared with antimicrobial chemotherapeutic drugs (ACD) against isolates of Staphylococcus aureus in vitro. Used clinical strains of S. aureus, isolated from 20 patients, aged 19 to 25 years. The susceptibility of microorganisms to ACD was determined on the MPA medium by disk-diffusion method. Staphylococcal bacteriophage sensitivity scores wer

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12

López-Carballo, Gracia, Pilar Hernández-Muñoz, and Rafael Gavara. "Photoactivated Self-Sanitizing Chlorophyllin-Containing Coatings to Prevent Microbial Contamination in Packaged Food." Coatings 8, no. 9 (2018): 328. http://dx.doi.org/10.3390/coatings8090328.

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Chlorophyllins are semi-synthetic porphyrins obtained from chlorophyll that—when exposed to visible light—generate radical oxygen substances with antimicrobial activity. In this work, chlorophyllins incorporated with polyethylene (PE), polyvinyl alcohol (PVOH), (hydroxypropyl)methyl cellulose (HPMC), and gelatin (G) were formulated for application as coatings in packages providing antimicrobial activity after photoactivation. First, the antimicrobial properties of two porphyrins (sodium magnesium chlorophyllin, E-140, and sodium copper chlorophyllin, E-141) were analyzed against L. monocytogen

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13

Beniuk, V. O., N. M. Hychka, T. V. Kovaliuk, et al. "Modern trends in the treatment of bacterial vaginosis in primigravida in the first half of gestation." Reproductive health of woman, no. 3 (June 18, 2024): 88–94. http://dx.doi.org/10.30841/2708-8731.3.2024.306430.

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Pregnancy with bacterial vaginosis (BV) is accompanied by a high risk of various obstetric and perinatal complications, including miscarriage, preterm birth, placental dysfunction, premature rupture of membranes, chorionamnionitis, polyhydramnios, etc. Screening for BV is carried out in the first half of pregnancy during the registration of a woman, however, taking into account the gestational age, many drugs with antimicrobial and antiseptic effects are categorically contraindicated, as they have an embryo- and fetotoxic effect.Timely detection and correction of microbiocenosis disorders of t

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14

V.O., Beniuk, Hychka N.M., Kovaliuk T.V., et al. "Modern trends in the treatment of bacterial vaginosis in primigravida in the first half of gestation." Reproductive Health of Woman, no. 3 (June 18, 2024): 88–94. https://doi.org/10.30841/2708-8731.3.2024.306430.

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Pregnancy with bacterial vaginosis (BV) is accompanied by a high risk of various obstetric and perinatal complications, including miscarriage, preterm birth, placental dysfunction, premature rupture of membranes, chorionamnionitis, polyhydramnios, etc. Screening for BV is carried out in the first half of pregnancy during the registration of a woman, however, taking into account the gestational age, many drugs with antimicrobial and antiseptic effects are categorically contraindicated, as they have an embryo- and fetotoxic effect.Timely detection and correction of microbiocenosis disorders of t

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15

Petrović, Sanja, Saša Savić, Jelena Zvezdanović, and Aleksandar Lazarević. "Investigations of commercial sodium copper chlorophyllin degradation after ultraviolet irradiation." Advanced Technologies 12, no. 2 (2023): 43–49. http://dx.doi.org/10.5937/savteh2302042p.

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Chlorophyllins are naturally derived colors that provide green hues to food products in oil- and water-based systems. Due to their good antimicrobial activity, in order not to contaminate the surface of food products and to increase product expiration dates and safety, the use of commercial chlorophyllin is common in the form of antimicrobial films that could cover fresh or processed food. UV irradiation effects on commercial sodium copper chlorophyllin are examined to estimate the potential application risk of this chlorophyll derivative for use in foods and cosmetics. Photodegradation of an

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16

Tulub, Iryna, and Nadiya Burda. "Study of antimicrobial activity of Zinnia elegans raw materials." Annals of Mechnikov Institute, no. 4 (December 4, 2023): 150–53. https://doi.org/10.5281/zenodo.10255334.

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<strong>Introduction. </strong>This work is a logical continuation of the study of raw materials of <i>Zinnia elegans</i> Jacq., Asteraceae family, which we started in previous works devoted to phytochemical study. For a comprehensive and in-depth study of this plant, it was appropriate to pay attention to the types of pharmacological activity. From a review of the literature, it is known that representatives of the genus <i>Zinnia </i>L. have antimicrobial and antifungal activity. In particular, foreign scientists investigated the antimicrobial properties of ethyl acetate and hexane

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17

Sachuk, R. N. "ЕФЕКТИВНІСТЬ «МАЗІ ДЛЯ РАН» У КОМПЛЕКСНІЙ ТЕРАПІЇ ПРИ ЛІКУВАННІ РВАНИХ РАН ДІЙОК ВИМЕНІ КОРІВ". Scientific Messenger of LNU of Veterinary Medicine and Biotechnologies 18, № 3(71) (2016): 91–94. http://dx.doi.org/10.15421/nvlvet7121.

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In the study of cows’ mammary glands pathologies it was determined that the udder wounds constitute 1.2% in the overall structure of diseases. The peak of traumatism on cows’ breast wounds falls on summer (pasture–range period) – 77.3%, resulting from offences of sanitary requirements for cattle pasture and grazing. While testing new treatment regimens it was set the high efficiency of «Ointments for wounds» based on essential oils of Siberian Cedar, Eucalyptus, Clove, Cedar, Tea Tree and chlorophyllipt oil solution for treatment of avulsive wounds of cows’ udder teats. It has been proven the

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18

Zaviryukha, H. A., U. M. Yanenko, and T. B. Vasylieva. "Influence of antibacterial agents on vaccine strains of Anthrax." Ukrainian Journal of Ecology 10, no. 5 (2020): 29–35. http://dx.doi.org/10.15421/2020_202.

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Neutralization of spore-forming pathogenic microflora is carried out by solutions of disinfectants repeatedly. Antibacterial agents when used uncontrolled can reduce the sensitivity of microorganisms and as a result cause severe complications. Of considerable interest is the combined use of antibiotics with antibacterial drugs of plant origin. The use of antimicrobial agents of plant origin is due to their low toxicity, the possibility of long-term use, greater availability and ability to biodegradation, while synthetic drugs: antibiotics, fluoroquinolones, antiseptics have strong activity. Th

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19

Sachuk, R. N. "Efficiency of the preparation on the basis of essential oils and oily solution of chlorophyllipt in the treatment of nipples’ hyperkeratosis of the udder of cows." Bulletin "Veterinary biotechnology" 34 (2019): 140–46. http://dx.doi.org/10.31073/vet_biotech34-17.

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Minukhin, Valery, Nadezhda Sklyar, Natalia Medvedovska, Еugenia Malyshevska, and Tetyana Kolotova. "135 YEARS OF HISTORY AND MODERNITY OF THE STATE INSTITUTION «I. I. MECHNIKOV INSTITUTE OF MICROBIOLOGY AND IMMUNOLOGY OF THE NATIONAL ACADEMY OF MEDICAL SCIENCES OF UKRAINE»." JOURNAL OF THE NATIONAL ACADEMY OF MEDICAL SCIENCES OF UKRAINE, no. 3 2021 (October 29, 2021): 218–28. http://dx.doi.org/10.37621/jnamsu-2021-3-8.

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The article is devoted to the results of a retrospective study of the historical path of formation and development of scientific research in State Institution «I. I. Mechnikov Institute of Microbiology and Immunology of the NAMS of Ukraine». The Institute as a scientific institution of anti-epidemic profile was founded in May 1886. At the beginning of the last century, the Institute turned into a major scientific and practical center of pre-revolutionary Russia for the fight against infectious diseases. Already in 1913-1914 the Institute produced 6 types of sera and 7 vaccines. In 1920 the Ins

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21

Shulga, L. I., K. S. Bezkrovna, D. P. Soldatov, and T. Р. Osolodchenko. "BURNET ROOTS EXTRACT DRY: STUDY OF PHARMACO-TECHNOLOGICAL AND ANTIBACTERIAL PROPERTIES." Annals of Mechnikov Institute, no. 3 (October 2, 2019): 39–43. https://doi.org/10.5281/zenodo.3469428.

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<strong>Introduction.</strong> The basis for timely development of new drug products, in particular the herbal ones, for therapy of the digestive system diseases is an increase in the total number of gastroenterological patients. The surveys of the domestic pharmaceutical market as for the offer of the herbal drug products used for treatment of various diseases of the digestive system have found a limited range of the drugs based on the substances obtained from medicinal herbs and expediency of search for promising herbal sources. Based on the experience of the traditional medicine, Greater Bu

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Lezhnevа, L. P., A. M. Temirbulatova, E. F. Stepanova, and D. V. Veselova. "THE DYNAMICS OF WOUND HEALING IN THE TREATMENT WITH THE OINTMENT WITH A DRY EXTRACT OF POTENTILLA." Kuban Scientific Medical Bulletin 25, no. 6 (2018): 105–9. http://dx.doi.org/10.25207/1608-6228-2018-25-6-105-109.

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Aim. The study was designed for the evaluation of the effect of ointments with dry extracts of potentilla on the dynamics of the healing process of full-thickness skin wounds.Materials and methods. The wound healing activity estimation of the proposed dosage form was conducted on white Wistar rats. The results of macroscopic studies (the area of the wound defect, the state of the scab, the presence of hemorrhage beneath it, the degree of inflammatory processes in the underlying tissues, including deeply located tissue structures, up to the muscle elements) and the results of histological exami

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23

Kurbanova, A. Yu, V. I. Egorov, I. A. Vasilenko, G. A. Golubovskii, and D. V. Kassina. "Integrated approach in conservative treatment of chronic tonsillitis." Russian Otorhinolaryngology 22, no. 6 (2023): 62–72. http://dx.doi.org/10.18692/1810-4800-2023-6-62-72.

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Chronic tonsillitis (CT) is one of the most common diseases among the pathologies of the ENT organs; in outpatient practice, its share ranges from 4% to 35%. The palatine tonsils (PT) are participants in cellular and humoral immunity. It is important to develop new therapeutic approaches that most effectively influence the tissue focus of inflammation. The attention of clinicians is drawn to the use of physiotherapeutic methods of treating CT. Data were obtained on the ability of nitric oxide (NO) to penetrate deep into tissue through intact skin and mucous membranes. We hypothesized that incl

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24

Romodin, L. A. "Spectrophotometric determination of sodium-copper chlorophyllin level in lymphocytes." Биофизика 68, no. 4 (2023): 660–66. http://dx.doi.org/10.31857/s0006302923040051.

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This study raises the question of whether it is possible to determine the appearance of sodium-copper chlorophyllin in lymphocytes. To answer this question, the content of chlorophyllin was determined in lymphocyte lysate previously incubated in a medium containing 300 uM of copper chlorophyllin. Significant amounts of chlorophyllin were observed in the lysate, thus, suggesting that chlorophyllin is able to enter cells. However, the question remains as to whether chlorophyllin can pass through the nuclear membrane. Based on our own data and information obtained from the scientific literature,

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Suzuki, Toshiyuki, Tadashi Kunieda, Fumiko Murai, Satoshi Morioka, and Yuzo Shioi. "Mg-dechelation activity in radish cotyledons with artificial and native substrates, Mg-chlorophyllin a and chlorophyllide a." Plant Physiology and Biochemistry 43, no. 5 (2005): 459–64. http://dx.doi.org/10.1016/j.plaphy.2005.03.009.

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Wang, Yi-Ting, Chih-Hui Yang, Keng-Shiang Huang, and Jei-Fu Shaw. "Chlorophyllides: Preparation, Purification, and Application." Biomolecules 11, no. 8 (2021): 1115. http://dx.doi.org/10.3390/biom11081115.

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Chlorophyllides can be found in photosynthetic organisms. Generally, chlorophyllides have a-, b-, c-, d-, and f-type derivatives, and all chlorophyllides have a tetrapyrrole structure with a Mg ion at the center and a fifth isocyclic pentanone. Chlorophyllide a can be synthesized from protochlorophyllide a, divinyl chlorophyllide a, or chlorophyll. In addition, chlorophyllide a can be transformed into chlorophyllide b, chlorophyllide d, or chlorophyllide f. Chlorophyllide c can be synthesized from protochlorophyllide a or divinyl protochlorophyllide a. Chlorophyllides have been extensively use

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Khan, Seemrose, Ihtisham Ul Haq, Imran Ali, et al. "Antibacterial and Antibiofilm Potential of Chlorophyllin Against Streptococcus mutans In Vitro and In Silico." Antibiotics 13, no. 9 (2024): 899. http://dx.doi.org/10.3390/antibiotics13090899.

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Background: Streptococcus mutans is a leading causative agent of dental caries and exerts pathogenicity by forming biofilms. Dental caries continues to be a significant public health issue worldwide, affecting an estimated 2.5 billion people, showing a 14.6% increase over the past decade. Herein, the antibacterial potential of Chlorophyllin extracted from Spinacia oleracea was evaluated against biofilm-forming S. mutans via in vitro and in silico studies. Methodology: The antimicrobial activity of chlorophyllin extract against S. mutans isolates was tested using the agar well diffusion method.

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Horban, I., M. Pasichnyk, N. I. Mykyyevych, and N. O. Mykyyevych. "TREATMENT EFFICACY FOR PERIODONTAL DISEASES IN MIDDLE-AGED INDIVIDUALS." Актуальні проблеми сучасної медицини: Вісник Української медичної стоматологічної академії 24, no. 1 (2024): 51–55. http://dx.doi.org/10.31718/2077-1096.24.1.51.

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The aim of the study is to evaluate and analyze the effectiveness of the proposed treatment mode for periodontal disease in middle-aged individuals.  Subjects and methods.The study comprised 62 individuals aged 46 to 60 years, including 32 men and 30 women with periodontal tissue diseases. Among them there were 24 patients diagnosed with chronic catarrhal gingivitis, and 38 patients with generalized periodontitis at the initial-I degree of development. The examinations were conducted at the Dental Medical Centre of Danylo Halytskyi Lviv National Medical University. The comparison g

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Buchovec, Irina, Laurita Klimkaitė, Edita Sužiedėlienė, and Saulius Bagdonas. "Inactivation of Opportunistic Pathogens Acinetobacter baumannii and Stenotrophomonas maltophilia by Antimicrobial Photodynamic Therapy." Microorganisms 10, no. 3 (2022): 506. http://dx.doi.org/10.3390/microorganisms10030506.

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Acinetobacter baumannii and Stenotrophomonas maltophilia are opportunistic pathogens causing hospital infections with limited treatment options due to bacterial multidrug resistance. Here, we report that antimicrobial photodynamic therapy (aPDT) based on the natural photosensitizers riboflavin and chlorophyllin inactivates A. baumannii and S. maltophilia. The riboflavin and chlorophyllin photostability experiments assessed the photomodifications of photosensitizers under the conditions subsequently used to inactivate A. baumannii and S. maltophilia. A. baumannii planktonic cells were more sens

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Clark, Nicole F., Andrew W. Taylor-Robinson, and Kirsten Heimann. "Could chlorophyllins improve the safety profile of beta-d-N4-hydroxycytidine versus N-hydroxycytidine, the active ingredient of the SARS-CoV-2 antiviral molnupiravir?" Therapeutic Advances in Drug Safety 13 (January 2022): 204209862211077. http://dx.doi.org/10.1177/20420986221107753.

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Plain Language Summary Could natural plant pigment (chlorophyll) derivatives (chlorophyllins) improve the safety of the antiviral Molnupiravir, used to treat COVID-19 disease? Molnupiravir, a specific SARS-CoV-2 antiviral, may cause adverse genetic changes and thereby create potential host cell damage (through genotoxicity and DNA stressors). In our opinion, this side effect of treatment could be reduced if the antiviral was taken as a combined therapy with chlorophyllins. Specifically, we hypothesise that chlorophyllins might improve the overall effectiveness of molnupiravir, typically used t

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Richter, Krüger, Prasad, et al. "Using Colistin as a Trojan Horse: Inactivation of Gram-Negative Bacteria with Chlorophyllin." Antibiotics 8, no. 4 (2019): 158. http://dx.doi.org/10.3390/antibiotics8040158.

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Colistin (polymyxin E) is a membrane-destabilizing antibiotic used against Gram-negative bacteria. We have recently reported that the outer membrane prevents the uptake of antibacterial chlorophyllin into Gram-negative cells. In this study, we used sub-toxic concentrations of colistin to weaken this barrier for a combination treatment of Escherichia coli and Salmonella enterica serovar Typhimurium with chlorophyllin. In the presence of 0.25 µg/mL colistin, chlorophyllin was able to inactivate both bacteria strains at concentrations of 5–10 mg/L for E. coli and 0.5–1 mg/L for S. Typhimurium, wh

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Akif, Faheem Ahmad, Mona Mahmoud, Binod Prasad, et al. "Polyethylenimine Increases Antibacterial Efficiency of Chlorophyllin." Antibiotics 11, no. 10 (2022): 1371. http://dx.doi.org/10.3390/antibiotics11101371.

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Polyethylenimines (PEIs), a group of polycationic molecules, are known to impair the outer membrane of Gram-negative bacteria and exhibit antimicrobial activity. The outer membrane of Gram-negative strains hinders the uptake of photosensitizer chlorophyllin. In this study, we report chlorophyllin and branched PEI combinations’ activity against Escherichia coli strains DH5α and RB791, Salmonella enterica sv. Typhimurium LT2, and Bacillus subtilis 168. The minimal bactericidal concentration (MBC) was determined by plating cells treated with different concentrations of PEI and chlorophyllin on ag

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Leite, Vessia Silva, Rodrigo Juliano Oliveira, Tatiane Yumi Nakamura Kanno, Mario Sergio Mantovani, Estefânia Gastaldello Moreira, and Maria José Sparça Salles. "Chlorophyllin in the intra-uterine development of mice exposed or not to cyclophosphamide - doi: 10.4025/actascihealthsci.v35i2.12470." Acta Scientiarum. Health Sciences 35, no. 2 (2013): 201. http://dx.doi.org/10.4025/actascihealthsci.v35i2.12470.

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Chlorophyllin, a sodium-copper salt synthesized from chlorophyll, has already proved to have anticlastogenic, antimutagenic and anticarcinogenic activity, however few are the studies in the teratogenicity area. The present study evaluated the effects of chlorophyllin in intra-uterine development of mice exposed or not to cyclophosphamide. Pregnant females were divided into 8 groups of 15 animals each, G01 - PBS (0.1 mL 10.0-1 g) orally; G02 – cyclophosphamide (20.0 mg kg-1) i.p.; G03, G04 and G05 - chlorophyllin at concentrations of (5.0, 10.0 and 15.0 mg kg-1) orally; G06, G07 and G08 (5.0, 1

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Krüger, Marcus, Peter Richter, Sebastian Strauch, et al. "What an Escherichia coli Mutant Can Teach Us About the Antibacterial Effect of Chlorophyllin." Microorganisms 7, no. 2 (2019): 59. http://dx.doi.org/10.3390/microorganisms7020059.

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Due to the increasing development of antibiotic resistances in recent years, scientists search intensely for new methods to control bacteria. Photodynamic treatment with porphyrins such as chlorophyll derivatives is one of the most promising methods to handle bacterial infestation, but their use is dependent on illumination and they seem to be more effective against Gram-positive bacteria than against Gram-negatives. In this study, we tested chlorophyllin against three bacterial model strains, the Gram-positive Bacillus subtilis 168, the Gram-negative Escherichia coli DH5α and E. coli strain N

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Kumar, Navneet, and Vinay Kumar Singh. "Effect of chlorophyllin bait on acetylcholinesterase and cytochrome oxidase activities in the nervous tissue of Lymnaea acuminata with exposure of sunlight and red light." European Journal of Biological Research 6, no. 4 (2016): 254–59. https://doi.org/10.5281/zenodo.163653.

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This study has focused on the effect of chlorophyllin bait on acetylcholinesterase and cytochrome oxidase activities in the nervous tissue of<strong> </strong><em>Lymnaea acuminata </em>with exposure of sunlight and red light. Treatment with 24 h LC<sub>50 </sub>chlorophyllin (40% and 80%) at sunlight and red light exposure in infected and uninfected snails lasted for 24 h caused strong inhibition in the activities of acetylcholinesterase and cytochrome oxidase with a dose-dependent manner. The maximum inhibition of AChE (54.91% of control) and cytochrome oxidase (55.54% of control) were obser

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D´Epiro, Gláucia Fernanda Rocha, Simone Cristine Semprebon, Andressa Megumi Niwa, et al. "Chlorophyllin attenuates the effects of benzo[a]pyrene in human hepatoma HepG2/C3A cells." Acta Scientiarum. Biological Sciences 45 (December 6, 2023): e68266. http://dx.doi.org/10.4025/actascibiolsci.v45i1.68266.

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Chlorophyllin, a semisynthetic compound derived from chlorophyll, has been a focus in cancer prevention because it exerts important biological activities, such as antigenotoxic, antioxidative and anticarcinogenic activities. The aim of this study was to evaluate the effect of chlorophyllin against benzo[a]pyrene toxicity in HepG2/C3A cells. Cells were co-treated (chlorophyllin plus benzo[a]pyrene) and the cell viability, cell growth kinetics, cell cycle, and apoptosis were evaluated. The mRNA levels of cell cycle and apoptotic genes were analyzed. Our results showed that chlorophyllin reduce t

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Rady, Magda H., Asmaa M. Ammar, Areej A. Al-Khalaf, et al. "Semi-Field Evaluation and Genotoxicity of Chlorophyllin Applied Against Aedes aegypti Larvae (Diptera, Culicidae)." Insects 16, no. 3 (2025): 255. https://doi.org/10.3390/insects16030255.

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Dengue fever is a mosquito-borne viral infection that recently appeared in Upper Egypt. Globally, more than 50 million new infections occur annually. It currently lacks effective treatment, necessitating vector control strategies targeting Aedes aegypti. This study investigates the potential of chlorophyllin as a control agent against dengue vectors. Chlorophyllin was characterized by FTIR analysis. The singlet oxygen quantum yield was determined by comparing the luminescence intensity at 1270 nm with that of phenalenone, yielding a value of 0.18. LC50 and LC90 values were calculated for chlor

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Arum, Puspito, Lisyani B. Suromo, and Niken Puruhita. "Pengaruh pemberian klorofilin berbagai dosis terhadap indeks fagositosis makrofag dan kadar nitric oxide mencit BALB/c yang diinfeksi dengan Salmonella typhimurium." Jurnal Gizi Indonesia (The Indonesian Journal of Nutrition) 2, no. 2 (2014): 77–81. http://dx.doi.org/10.14710/jgi.2.2.78-82.

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Background: Immune responses to eliminate Salmonella infection are by activating macrophage and by producing NO. Chlorophyllin is a chlorophyll derivate that has immunomodulator properties. Objective: The aim of this study was to prove effect of chlorophyllin in macrophage phagocytosis index and NO level. Methods: A post test only controlled group design was conducted in 5 groups Balb/c mice (negative control, positive control, dosage 100 µg/200 g BW, dosage 200 µg/200 g BW and dosage 380 µg/200 g BW). Macrophage phagocytosis index was measured by counting cells that phagocyte latexs particles

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H, Alhasan, Alahmadi N, and Wadhawan J. "Homogeneous electron-transfer of chlorophyll and its derivative chlorophyllin at gold electrode." Innovaciencia Facultad de Ciencias Exactas Físicas y Naturales 7, no. 1 (2019): 1–17. http://dx.doi.org/10.15649/2346075x.751.

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Introduction: Chlorophyll is a light harvesting pigment, which absorbs light in the visible spectrum of sunlight and promotes electron transfer, Chlorophyllin (CHL) is One of the most important derivative molecules of chlorophyll. Nowadays, chlorophyll pigment and its derivatives are utilised in organic photosynthetic solar cells for their desirable photovoltaic properties. Cyclic voltammetry (CV) is an essential technique. It is extensively used to study electroactive species to interpret the intermediates of reactions, supply information about the thermodynamics of oxidation-reduction reacti

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Sachuk, R. N. "Дослідження ембріотоксичної дії препарату для зовнішнього використання «Мазь для ран» на лабораторних тваринах". Scientific Messenger of LNU of Veterinary Medicine and Biotechnologies 19, № 78 (2017): 162–66. http://dx.doi.org/10.15421/nvlvet7833.

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The results of experiments showed one of the aspects of the application safety of the new preparation «Ointment for Wounds», which is intended for external use to bovine cattle, horses, sheep, goats, swine, fur-bearing animals, rabbits, dogs and cats. The preparation formula includes essential oils of Siberian Cedar, Eucalyptus, Tea Tree, Cedar, Clove, and chlorophyllipt oil solution. Pre-clinical trial of the «Ointment for Wounds» were carried out on pregnant rats, through repeated dermal application in the period from the 1st to the 19th day of pregnancy, and it did not cause toxic effects o

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Reinbothe, C., K. Apel, and S. Reinbothe. "A light-induced protease from barley plastids degrades NADPH:protochlorophyllide oxidoreductase complexed with chlorophyllide." Molecular and Cellular Biology 15, no. 11 (1995): 6206–12. http://dx.doi.org/10.1128/mcb.15.11.6206.

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The NADPH:protochlorophyllide oxidoreductase precursor protein (pPorA) of barley (Hordeum vulgare L. cv. Carina), synthesized from a full-length cDNA clone by coupling in vitro transcription and translation, is a catalytically active protein. It converts protochlorophyllide to chlorophyllide in a light- and NADPH-dependent manner. At least the pigment product of catalysis remains tightly bound to the precursor protein. The chlorophyllide-pPorA complex differs markedly from the protochlorophyllide-pPorA complex with respect to sensitivity to attack by a light-induced, nucleus-encoded, and energ

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Rodríguez-López, María Isabel, Vicente M. Gómez-López, Viktorija Lukseviciute, and Zivile Luksiene. "Modeling the Inactivation and Possible Regrowth of Salmonella enterica Treated with Chlorophyllin-Chitosan and Visible Light." Food Technology and Biotechnology 58, no. 1 (2020): 64–70. http://dx.doi.org/10.17113/ftb.58.01.20.6374.

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The study focuses on predictive modelling of inactivation of Salmonella enterica after treatment with chlorophyllin-chitosan complex and visible light. Salmonella cells were incubated with chlorophyllin-chitosan complex (0.001 % chlorophyllin and 0.1 % chitosan) for different times (5-60 min) and then illuminated with visible light (λ=405 nm, He=38 J/cm2). Inactivation curves and post-treatment regrowth curves were built based on microbiological viability tests and data were fitted to ten inactivation and two regrowth models. The photoactivated complex reduced Salmonella population, which were

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Alzamly, Ahmed, Ali Alawadhi, Salwa Ahmed, Maram Bakiro, and Muna Bufaroosha. "Photosensitizer Using Visible Light: An Undergraduate Laboratory Experiment Utilizing an Affordable Photocatalytic Reactor." International Journal for Innovation Education and Research 6, no. 11 (2018): 74–84. http://dx.doi.org/10.31686/ijier.vol6.iss11.1232.

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In this experiment, the visible light reactive photosensitizer (PS) derived from chlorophyllin sodium copper salt has been synthesized via a simple synthetic route. The enhanced photocatalytic activity for the decomposition of the pharmaceutical compound Diclofenac Potassium available as Voltfast sachets under visible light irradiation was demonstrated by comparing the photocatalytic decomposition of Diclofenac Potassium in the presence and absence of the new synthesized visible light photosensitizer under the same photocatalytic conditions. Based on the experimental results, higher activity w

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Guo, Haitao, Xiaoben Pan, Richeng Mao, et al. "Alkylated Porphyrins Have Broad Antiviral Activity against Hepadnaviruses, Flaviviruses, Filoviruses, and Arenaviruses." Antimicrobial Agents and Chemotherapy 55, no. 2 (2010): 478–86. http://dx.doi.org/10.1128/aac.00989-10.

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ABSTRACTWe screened ∼2,200 compounds known to be safe in people for the ability to reduce the amount of virion-associated hepatitis B virus (HBV) DNA in the culture medium of producer cells. These efforts led to the discovery of an alkylated porphyrin, chlorophyllide, as the compound that achieved the greatest reduction in signal. Here we report that chlorophyllide directly and quantitatively disrupted HBV virions at micromolar concentrations, resulting in the loss of all detectable virion DNA, without detectably affecting cell viability or intracellular viral gene products. Chemophores of chl

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Franck, Fabrice, and Georg H. Schmid. "The Role of N ADPH in the Reversible Phototransformation of Chlorophyllide P682 into Chlorophyllide P678 in Etioplasts of Oat." Zeitschrift für Naturforschung C 40, no. 11-12 (1985): 832–38. http://dx.doi.org/10.1515/znc-1985-11-1213.

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Abstract Absorption spectra and room temperature fluorescence variations upon light excitation were studied in etioplasts in which the protochlorophyllide had been reduced to chlorophyllide prior to the experiment. In the presence of 1 mᴍ NADPH, the absorption band was located around 682 nm and the fluorescence variations reflected the occurrence of the chlorophyllide microcycle (reversible phototransformation of chlorophyllide P682 into chlorophyllide P678), whereas, in the absence of NADPH, the absorption band was located around 676 nm and the fluorescence exhibited only a slow decrease with

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Romodin, L. A. "Chlorophyllin Inhibits Lipid Peroxidation Triggered by the Fenton Reaction." Биофизика 69, no. 1 (2024): 5–9. http://dx.doi.org/10.31857/s0006302924010013.

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The Fenton reaction was used to model a system in which particles similar to those formed during water radiolysis are created. A method of registering the chemiluminescence was applied to the analysis of the chlorophyllin-induced suppression of reactions caused by hydroxyl radicals. It has been shown that sodium copper chlorophyllin dose-dependently inhibits the chemiluminescence which accompanies the Fenton-mediated oxidation of phosphatidic acid. This leads us to conclude that copper chlorophyllin can inhibit the metabolism of lipid radiotoxins, also known as lipid peroxidation, caused by th

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Romodin, L. A., and M. A. Ignatov. "The Comet Assay Did Not Reveal a Decrease in DNA Damage to Lymphocytes when Exposed to X-Ray Radiation under the Action of Na-Cu-chlorophyllin." Радиационная биология. Радиоэкология 63, no. 4 (2023): 394–402. http://dx.doi.org/10.31857/s0869803123040070.

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The search for effective but non-toxic radioprotective agents remains the main task of radiobiology. Accor-ding to a number of reports, these may include preparations based on chlorophyll, in particular, chlorophyllin – a water-soluble product of its saponification. Since many researchers assign DNA damage a key role in the development of negative consequences of ionizing radiation, we conducted an experiment on X-ray irradiation of a suspension of lymphocytes in solutions of sodium-copper chlorophyllin in the concentration range of 5–100 micromoles. During it, using an alkaline modification o

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Chernomorsky, Simon. "Quantitative Procedure for CWorophyllin Copper Complex." Journal of AOAC INTERNATIONAL 77, no. 3 (1994): 756–57. http://dx.doi.org/10.1093/jaoac/77.3.756.

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Abstract The reliability of the currently used quantitative assay for commercially available chlorophyllin copper complex is discussed. It was shown that optical measurements at 405 nm can overestimate the purity of the preparation by 16.4–49.5%. This conclusion is from comparative studies using spectrophotometry at 405 nm and elemental analysis (copper content) of chlorophyllin copper complex. Spectrophotometry at 630 nm resulted in closer agreement with data calculated from elemental analysis. These observations have to be taken into consideration by those involved in the manufacture and dis

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Kovalev, V. M., O. O. Mykhailenko, A. V. Krechun, and T. P. Osolodchenko. "ANTIMICROBIAL ACTIVITY OF EXTRACTS OF IRIS HUNGARICA AND IRIS SIBIRICA." Annals of Mechnikov Institute, no. 2 (June 7, 2017): 57–64. https://doi.org/10.5281/zenodo.803878.

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<strong>Introduction. </strong>Referring to the latest data, infectious diseases command a large part of among the total number of pathologies in the world and are an important problem in medicine. The leading role in prevention and treatment of diseases of microbial origin belongs to antibacterial chemotherapeutic agents. Advantages of antibiotics of synthetic origin are the high activity compared to phytogenic drugs. But it is known that microorganisms can release the resistance to synthetic antibiotics, so the use of drugs based on the plant materials is appropriate: phytogenic drugs more r

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Chaturvedi, Divya, Kavita Singh, and Vinay Kumar Singh. "Therapeutic and pharmacological aspects of photodynamic product chlorophyllin." European Journal of Biological Research 9, no. 2 (2019): 64–76. https://doi.org/10.5281/zenodo.2638869.

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Medicinal plants have been used for thousands of years to flavor and conserve food, to treat health disorders and to prevent diseases including epidemics. They can provide biologically active molecules and lead structures for development of modified derivatives with enhanced activity or reduced activity.  The isolation and identification of active principles and elucidation of the mechanism of action of a drug is of paramount importance. One such compound is chlorophyllin, a water soluble analogue of the ubiquitous green pigment chlorophyll. It acts as an effective inhibitor of aflatoxin

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