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Rozprawy doktorskie na temat „Chloroquine”

Autor: Grafiati

Data publikacji: 4 czerwca 2021

Data aktualizacji: 25 lipca 2025

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1

Mahon, Gerald J. "Studies on chloroquine retinopathy." Thesis, Queen's University Belfast, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.388235.

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2

LAGARDE, CLAIRE. "Intoxication aigue par la chloroquine." Lille 2, 1997. http://www.theses.fr/1997LIL2P052.

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3

Eliot, Marc. "La chloroquine : aspect toxicologique actuel." Lyon 1, 1990. http://www.theses.fr/1990LYO1M243.

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4

Caliez, Catherine. "Contribution au dosage immunochimique de la chloroquine dans les milieux biologiques." Paris 5, 1988. http://www.theses.fr/1988PA05P608.

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5

Kendrick, Kelsie Lynn. "Mimicking Metabolism of a Reversed Chloroquine Antimalarial." PDXScholar, 2014. https://pdxscholar.library.pdx.edu/open_access_etds/2085.

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The aim of this study was to elucidate the oxidation products of a candidate antimalarial drug, PL69, using a porphyrin system and to determine the accuracy of the oxidation products produced, as compared to what is expected in metabolism. PL69 is a reversed chloroquine (RCQ) that is active against chloroquine resistant malaria. Porphyrin oxidation systems have been shown to mimic in vitro enzymatic metabolism reactions. PL69 and its known metabolite, PL16, were incubated with the porphyrin system, and then the oxidation products were collected and separated by HPLC. The oxidation products wer

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6

Onde, Olivier. "Actualités en réanimation pré-hospitalière et hospitalière immédiate des intoxications aigues par la chloroquine." Montpellier 1, 1989. http://www.theses.fr/1989MON11325.

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7

Jehl, Patrick. "Mécanismes de la chloroquinorésistance chez "Plasmodium falciparum" : intérêt de l'étude de la multirésistance des cellules cancéreuses." Paris 5, 1989. http://www.theses.fr/1989PA05P070.

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8

Ng, Anna. "Taste-masked and controlled-release formulations of chloroquine." Thesis, University College London (University of London), 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.267929.

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9

Saliba, Kevin John. "Chloroquine accumulation in Plasmodium falciparum isolated digestive vacuoles." Doctoral thesis, University of Cape Town, 1997. http://hdl.handle.net/11427/26631.

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Due to the development of drug-resistance by Plasmodium falciparum, the utilisation of chloroquine, a cheap and effective antimalarial has become limited. The mechanism of chloroquine-resistance is, at best, unresolved. This thesis describes an investigation of chloroquine accumulation in pure and intact Plasmodium falciparum isolated digestive vacuoles, the site of chloroquine accumulation and action. Marker enzymes and gel electrophoresis were used to demonstrate purity, and electron microscopy to verify integrity of isolated vacuoles. Using this method, vacuoles were isolated in a yield hig

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10

Murphy, Kevin Vincent. "Design and Synthesis of Novel Chloroquine-based Antimalarials." PDXScholar, 2015. https://pdxscholar.library.pdx.edu/open_access_etds/2623.

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Malaria is an infectious, often fatal disease that afflicts nearly 200 million people every year. The disease, characterized by recurring and extreme flu-like symptoms, is caused by the protozoan parasite Plasmodium falciparum. Victims usually contract the disease through a mosquito vector. Chloroquine is a chemotherapeutic that was introduced in the 1940s. For many years the drug was the foremost treatment of malaria, being effective and producing few side effects. Unfortunately, tolerance to chloroquine developed when the parasite evolved a resistance mechanism. Newer drugs have been develop

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11

Tesfaselassie, Elias Sibhatu. "Antimalarial Drug Discovery using Triazoles to Overcome Chloroquine Resistance." PDXScholar, 2015. https://pdxscholar.library.pdx.edu/open_access_etds/2506.

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Malaria is considered as one of the most prevalent and debilitating diseases affecting humans. Plasmodium falciparum is the most virulent form of the parasite which developed resistance to several antimalarial drugs. Chloroquine is one of the most successful antimalarials developed that is safe, effective, and cheap. However, its use has been limited due to the emergence of drug resistance. Click chemistry, particularly, the copper(I)-catalyzed reaction between azides and alkynes has shown to have a cutting-edge advantage in medicinal chemistry by its reliability, selectivity and biocompatibil

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12

Bot, Ba Njock Simon. "Chloroquine chez l'enfant impalude : étude de la pharmacocinétique et réponses clinique et parasitologique compte tenu des conditions du terrain." Paris 5, 1991. http://www.theses.fr/1991PA05P080.

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13

Biarnais, Tiphaine. "Modifications de la schizogonie et de la gamétocytémie en réponse à la chloroquine chez certains Plasmodium de Muridés." Tours, 2002. http://www.theses.fr/2002TOUR3303.

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Les phénomènes de résistance des Plasmodium aux médicaments sont impliqués dans l'extension du paludisme, ainsi que les variations de production des gamétocytes (stade responsable de la transmission) en présence de chimiothérapie médicamenteuse. Afin de mieux comprendre ces mécanismes, nous avons réalisé l'étude suivante sur des Plasmodium de muridés africains transmis à la souris blanche. Dans la première partie, nous avons étudié les différences schizogoniques induites par pression de chloroquine sur deux souches de Plasmodium, P. Berghei NK 65 et P. Berghei ANKA. Les deux souches, pourtant

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14

Maalla, Mahmalgi Jamila. "Mode d'action des antimalariques : détermination des sites de concentration des amino-4 quinoléïnes et des compartiments acides parasitaires chez des souches de Plasmodium berghei sensibles et résistantes à la chloroquine." Lille 1, 1987. http://www.theses.fr/1987LIL10159.

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15

How, Cheong Wen How Chan. "Paludisme chloroquinorésistant : à propos de 17 observations de chloroquinorésistance clinique observées entre 1986 et 1988." Université Louis Pasteur (Strasbourg) (1971-2008), 1989. http://www.theses.fr/1989STR1M181.

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16

Yvette, Mofenge Opute. "Novel adamantane-chloroquinolin conjugates to overcome plasmodium falciparum chloroquine resistance." University of the Western Cape, 2017. http://hdl.handle.net/11394/5930.

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Magister Scientiae - MSc (Pharmaceutical Chemistry)<br>Malaria poses devastating health and socioeconomic outcomes on global health especially among pregnant women and children below the age of 5 in endemic areas. This is exacerbated by Plasmodium falciparum resistance to available antimalarial drugs, especially chloroquine (CQ), which was the drug of choice for many years against the blood stage of malaria.

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17

Boulter, Matthew K. "Aspects of chloroquine resistance and its reversal in Plasmodium falciparum." Thesis, University of Liverpool, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.240437.

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18

Nweneka, Chidi Victor. "Chloroquine as a therapeutic option for mild post malaria anaemia." Thesis, University of Glasgow, 2011. http://theses.gla.ac.uk/2622/.

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Background: The relative importance of malaria anaemia as a cause of childhood morbidity and mortality varies between and within regions. However, malaria anaemia remains an important cause of childhood morbidity and mortality. It has been estimated that globally, severe malaria anaemia occurs 1.42 to 5.66 million times per annum and kills an estimated 190,000 to 974,000 under-5 children. Studies from different countries endemic for malaria have emphasised the importance of anaemia in malaria-associated morbidity and mortality. Most of these studies have conclusively shown that severe malaria

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19

Ayoun, Anthony-Charles. "La chloroquine ex-panacée du traitement antipaludique peut-elle être remplacée par la pyronaridine ?" Paris 5, 1998. http://www.theses.fr/1998PA05P251.

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20

Boinet, Sylvie. "Intoxications volontaires à la chloroquine : expériences du SAMU 34 de 1982 à 1988." Montpellier 1, 1989. http://www.theses.fr/1989MON11044.

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21

Johnson, David James. "Studies on the molecular basis of chloroquine resistance in Plasmodium falciparum." Thesis, University of Liverpool, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.273985.

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22

Hughes, Dyfrig Arwyn. "Mechanistic studies on the effects of diazepam on chloroquine-induced cardiotoxicity." Thesis, University of Liverpool, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.243244.

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23

Abessolo, Huguette-Valérie. "Synthèse, activité antipaludique et mécanisme d'action d'analogues métallocéniques de la chloroquine." Lille 1, 2000. https://pepite-depot.univ-lille.fr/RESTREINT/Th_Num/2000/50376-2000-432.pdf.

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Le paludisme, cause par un protozoaire du genre plasmodium, demeure la premiere endemie tropicale. L'extension de la resistance de plasmodium falciparum aux antipaludeens existants et le manque de vaccin, rend necessaire et urgent le developpement de nouvelles molecules antimalariques de nouveaux composes metalloceniques inspires de la chloroquine, principal medicament antipaludique, ont ete synthetises par greffage d'un noyau ferrocenique. Deux d'entre eux, la 7-chloro-4-(n,n-dimethylaminomethyl)-n-ferrocenylmethylamino-quinoleine 1 (ferroquine) et la 7-chloro-4-(n-methyl-n-ethylaminomethyl)-

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24

Nakano, Kenzo. "Chloroquine induces apoptosis in pancreatic neuroendocrine neoplasms via endoplasmic reticulum stress." Doctoral thesis, Kyoto University, 2021. http://hdl.handle.net/2433/263541.

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25

Obua, Celestino. "Fixed-dose chloroquine and sulfadoxine/pyrimethamine treatment of malaria : outcome and pharmacokinetic aspects /." Stockholm, 2007. http://diss.kib.ki.se/2007/978-91-7357-144-9/.

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26

Pundir, Sheetal. "The Characterization of the Novel Chloroquine Derivative VR23 for its Anticancer Properties." Thesis, Université d'Ottawa / University of Ottawa, 2015. http://hdl.handle.net/10393/32405.

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Since Bortezomib®, a proteasome inhibitor, was approved by US FDA for the treatment of multiple myeloma in 2003, proteasome is recognized as one of the most promising targets for cancer therapeutics. The proteasomes play a critical role in regulating the level of cellular proteins and recycling damaged and misfolded proteins. Although the activity of the proteasome is essential for normal cells, it is especially critical for the proliferation and survival of cancer cells. In an attempt to develop effective and safe proteasome inhibitor-based anticancer drugs, the Lee laboratory created a chemi

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27

Demazière, Jacques. "Intoxications aigues par la chloroquine a dakar : efficacite du diazepam, facteurs previsionnels de deces ; etude retrospective de 360 observations." Lyon 1, 1993. http://www.theses.fr/1993LYO1M042.

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28

Jambou, Ronan. "Evaluation des antipaludeens en zone de chloroquinoresistance recente : republique du cameroun." Nice, 1989. http://www.theses.fr/1989NICE6568.

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29

Alibert, Sandrine. "Synthèse de nouveaux dérivés 9,10-dihydro-9,10-éthano et éthénoanthracéniques : étude de leurs effets sur la résistance à la chloroquine chez Plasmodium falciparum." Aix-Marseille 2, 2002. http://theses.univ-amu.fr.lama.univ-amu.fr/2002AIX22952.pdf.

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30

Veignie, Étienne. "Mode d'action antimalarique de la chloroquine : rôle des propriétés acido-basiques des amino-4-quinoléines dans leur mécanisme de concentration intraparasitaire." Lille 1, 1990. http://www.theses.fr/1990LIL10108.

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Dans cette thèse, nous avons tenté de préciser quelques paramètres intervenant dans le mécanisme de concentration intraparasitaire de la chloroquine qu'ils soient d'origine parasitaire ou liés à la chloroquine des amino-4-quinoléines. Nous montrons que les vacuoles digestives des souches P. Berghei sensible et résistante à la chloroquine sont acides. D'autre part, nous démontrons que les propriétés basiques de la chloroquine, classiquement impliquées dans le mécanisme de concentration, se sont avérées insuffisantes pour rendre compte des fortes quantités de chloroquine accumulées par le parasi

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31

Slomianny, Christian. "Action de la chloroquine sur le processus de dégradation de l'hémoglobine chez Plasmodium sp. : étude ultrastructurale morphologique et cytochimique." Lille 1, 1986. http://www.theses.fr/1986LIL10043.

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32

Guillet, Aurélie Chiffoleau Anne. "Atteintes oculaires induites par les antipaludéens de synthèse la rétinopathie aux APS /." [S.l.] : [s.n.], 2007. http://castore.univ-nantes.fr/castore/GetOAIRef?idDoc=25246.

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33

GAILLARD, JOELLE. "La chloroquinoresistance du paludisme en afrique : a propos d'observations recemment etudiees a toulouse." Toulouse 3, 1988. http://www.theses.fr/1988TOU31275.

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34

Feng, Tzu-Shean. "Single and hybrid antimalarials based on artemisinin, chloroquine and ß-lactams : synthesis, antiplasmodial activity, cytotoxicity and effect of selected artemisinin-chloroquine hybrids on the parasitic endocytosis pathway." Doctoral thesis, University of Cape Town, 2009. http://hdl.handle.net/11427/6305.

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Includes abstract.<br>Includes bibliographical references.<br>Malaria remains to be one of the leading causes of morbidity and mortality throughout recorded history. It is caused by protozoan parasites of the genus Plasmodium, where P. falciparum is the most lethal. Current estimates are that over 500 million people are afflicted, while 3 million people die annually. With the emergence of resistance to antimalarial drugs in the malaria parasite, it is critical to develop new chemotherapeutic agents that can combat the disease and/or overcome resistance. This may be achieved by identifying mole

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35

Chatain, Guillaume C. "Towards an understanding of hemozoin formation and chloroquine resistance in Plasmodium falciparum." Thesis, McGill University, 2004. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=81609.

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Malaria is a worldwide disaster that is still killing two million lives annually. The recent rise of the epidemic is mainly attributed to the emergence of resistance to the most effective, affordable and safe antimalarial, chloroquine. Unfortunately, neither the mechanism of action of these 4-aminoquinolines nor the basis of chloroquine resistance is well understood. It has been noted that a known channel blocker, verapamil, is able to modulate chloroquine resistance.<br>In this study, a chemical biology approach was taken to gain some light into these mechanisms. The design, synthesis

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36

Ravichandran, Easwaran. "The fate of racemic chloroquine and its enantiomers in male F344 rats." Thesis, Imperial College London, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.404566.

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37

Nieuwoudt, Stephnie. "Preparation, stability and in vitro evaluation of liposomes containing chloroquine / Stephnie Nieuwoudt." Thesis, North-West University, 2010. http://hdl.handle.net/10394/4740.

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Malaria is currently a huge treat worldwide, as far as infections are concerned, and is responsible for thousands of deaths per annum. The dilemma associated with the development of anti–malarial drug resistance over the past few decades should be addressed as a matter of urgency. Novel drug delivery systems should be developed in order to employ new and existing anti–malarial drugs in the treatment and management of malaria. The aim of these delivery systems should include an improvement in the efficacy, specificity, acceptability and therapeutic index of anti–malarial drugs. Previous studies

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38

Bray, Patrick Gerrard. "Plasmodium falciparum : studies on the mechanism of chloroquine resistance and its reversal." Thesis, University of Liverpool, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.316597.

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39

Asamoah, Kojo Afedzie. "Effect of chloroquine on the glycaemic mechanisms in normal and diabetic rats." Thesis, University of Strathclyde, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.278506.

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40

Carlton, Jane M. R. "The genetics of chloroquine resistance in the rodent malaria parasite Plasmodium chabaudi." Thesis, University of Edinburgh, 1995. http://hdl.handle.net/1842/13312.

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The aim of this work has been to use linkage analysis to determine the chromosomal location of genes involved in chloroquine resistance in the rodent malaria parasite <I>Plasmodium chabaudi</I>. The <I>P. chabaudi</I> genome was found to contain 14 chromosomes. A genetic map of each chromosome was made using DNA markers. Most of the markers were known genes from other species of <I>Plasmodium</I>. Other markers were developed by the RAPD-PCR (random amplified polymorphic DNA-polymerase chain reaction) technique, the first time this method has been developed for use with <I>Plasmodium</I> paras

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41

Blackie, Margaret Anne Lillias. "New mono and bimetallic chloroquine derivatives : synthesis and evaluation as antiparasitic agents." Doctoral thesis, University of Cape Town, 2002. http://hdl.handle.net/11427/6975.

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Includes bibliographical references.<br>Several series of new ferrocenyl-quinoline antimalarial agents have been synthesised and fully characterised using standard spectroscopic and analytical techniques. The molecular structure of N-(7-Chloro-quinolin-4-yl)-N'-[2 -( N”,N""-dimethylaminomethyl)ferrocenylmethyl]-ethane-1.2-diamine has been determined by x-ray crystallography. N-(7-Chloro-quinolin-4-yl)-N'-[2-( N”, N""-dimethylaminomethyl)ferrocenylmethyl]-alkyl-1 ,n-diamine compounds were made where n = 2-6. These compounds contain a reactive secondary amine centre through which derivatisation

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42

Paguio, Michelle Fortaleza. "Biochemical and biophysical analysis of recombinant Plasmodium falciparum chloroquine resistance transporter (pfcrt)." Connect to Electronic Thesis (CONTENTdm), 2009. http://worldcat.org/oclc/525210083/viewonline.

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43

Yanze, Maximun Frédéric. "Recherches pharmacotechnique, physico-chimique et biomédicale sur les formes pharmaceutiques solides orales d'action rapide des médicaments du paludisme à Plasmodium falciparum." Montpellier 1, 2000. http://www.theses.fr/2000MON13511.

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44

VIGUIER, KOURTA MARIE-JEANNE. "Perturbations biologiques au cours du paludisme a plasmodium falciparum chloroquinoresistant." Toulouse 3, 1989. http://www.theses.fr/1989TOU31703.

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45

Ahmadi, Pirshahid Sina. "Sensitivity and Specificity of Multifocal Electroretinography in Detecting Chloroquine and Hydroxychloroquine Retinal Toxicity." Thesis, Université d'Ottawa / University of Ottawa, 2015. http://hdl.handle.net/10393/31997.

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To calculate the sensitivity and specificity of multifocal electroretinography (mfERG) in detection of chloroquine and hydroxychloroquine retinal toxicity, 120 eyes of 63 patients were evaluated using the currently recommended diagnostic tests. The results were compared to those of 54 eyes of 28 control subjects. The sensitivity and specificity of mfERG relative to the combination of automated visual fields and optical coherence tomography (the reference test) were calculated to be 87% and 86.5% respectively. However, analysis of the “false positive” cases proved that mfERG was more sensitive

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46

Salas, Fernandez Paloma. "Synthesis and biological activity of chloroquine ferrocenyl conjugates for the treatment of malaria." Thesis, University of British Columbia, 2012. http://hdl.handle.net/2429/43009.

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47

Watermeyer, Nicholas D. "Bioactive chloroquine-based ligands and their gold complexes as potential novel antimalarial agents." Master's thesis, University of Cape Town, 2008. http://hdl.handle.net/11427/6283.

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Includes bibliographical references.<br>Includes bibliographical references.<br>Chloroquine(CO)-derived 4-aminoquinolines have proven to be the most efficacious antimalarial drugs for both the treatment and prophylaxis of malaria. However, with the advent of drug resistance, their ability to treat the disease has been significantly hindered. Future research into the synthesis of new 4-aminoquinoline derivatives is warranted, since it has been found that the resistance is based on the identity of the side chain and not on the aminoquinoline ring, the functionality by which these compounds deriv

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48

Cabrera, Mynthia. "Analysis of the cellular and molecular mechanisms of Chloroquine Resistance in Plasmodium Falciparum." Connect to Electronic Thesis (CONTENTdm), 2009. http://worldcat.org/oclc/501018382/viewonline.

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49

Gunsaru, Bornface. "Simplified Reversed Chloroquines to Overcome Malaria Resistance to Quinoline-based Drugs." PDXScholar, 2010. https://pdxscholar.library.pdx.edu/open_access_etds/400.

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Malaria is a major health problem, mainly in developing countries, and causes an estimated 1 million deaths per year. Plasmodium falciparum is the major type of human malaria parasite, and causes the most infections and deaths. Malaria drugs, like any other drugs, suffer from possible side effects and the potential for emergence of resistance. Chloroquine, which was a very effective drug, has been used since about 1945, but its use is severely limited by resistance, even though it has mild side effects, and is otherwise very efficacious. Research has shown that there are chloroquine reversal a

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50

Delarue, Sandrine. "Conception, synthese et etude de l'activite antipaludique de derives 4-anilinoquinoleine." Lille 2, 2001. http://www.theses.fr/2001LIL2P256.

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