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Artykuły w czasopismach na temat „Chromosome 3p”

Autor: Grafiati

Data publikacji: 2 czerwca 2025

Data aktualizacji: 31 lipca 2025

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1

Dahiya, Rashmi, and Peter Ly. "Abstract A014: Modeling recurrent chromosomal alterations in renal cell carcinoma evolution." Cancer Research 83, no. 16_Supplement (2023): A014. http://dx.doi.org/10.1158/1538-7445.kidney23-a014.

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Abstract The loss of one copy of chromosome 3p represents an early truncal genetic event in the majority of clear cell renal cell carcinoma (ccRCC) tumors. Chromosome 3p loss can be initiated by chromothripsis, a process in which mis-segregated chromosomes entrapped within abnormal nuclear structures called micronuclei become pulverized into small genomic fragments. These fragments are then re-stitched together to form complex rearrangements that are accompanied by extensive segmental deletions that inactivate critical tumor suppressor genes located on chromosome 3p. Despite being a driver of

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2

Hötzel, Isidro, and William P. Cheevers. "A maedi–visna virus strain K1514 receptor gene is located in sheep chromosome 3p and the syntenic region of human chromosome 2." Journal of General Virology 83, no. 7 (2002): 1759–64. http://dx.doi.org/10.1099/0022-1317-83-7-1759.

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The maedi–visna lentivirus (MVV) induces encephalitis, interstitial pneumonia, arthritis and mastitis in sheep. While some MVV strains can enter cells of ruminant species only, others can enter cells from many species, including human, but not Chinese hamster cells. However, the identity of the receptor(s) used by MVV for entry is unknown. The MVV-K1514 receptor gene was localized in sheep and human chromosomes using hamster×sheep and hamster×human hybrid cell lines. Based on entry by a vector pseudotyped with the MVV-K1514 envelope, the MVV-K1514 receptor gene was mapped to sheep chromosome 3

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3

Journal, Baghdad Science. "Chromosomal aberrations and N-ras activation in human larynx carcinoma cell line Hep-2." Baghdad Science Journal 5, no. 3 (2008): 346–52. http://dx.doi.org/10.21123/bsj.5.3.346-352.

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In the present study, cytogenetic and molecular techniques were conducted to detect the chromosomal aneuploidy and the involvement of N and H genes in squamous larynx carcinoma cell line Hep-2.Our results showed that numerical and structural abnormalities were involved in larynx cancer Hep-2.The total number of chromosomes ranging from tripolyploidy in passage187to more than that in passage207.The more frequent chromosomes involved in numerical aberrations were chromosomes1,7,16,17 and 18. Structural chromosomal aberrations were also detected.Deletion of short arm was detected in chromosome 1(

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4

Al-Faisal, Abdul Hussain M., Amal M. Ali, and Nahi Y. Yassen. "Chromosomal aberrations and N-ras activation in human larynx carcinoma cell line Hep-2." Baghdad Science Journal 5, no. 3 (2008): 346–52. http://dx.doi.org/10.21123/bsj.2008.5.3.346-352.

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In the present study, cytogenetic and molecular techniques were conducted to detect the chromosomal aneuploidy and the involvement of N and H genes in squamous larynx carcinoma cell line Hep-2.Our results showed that numerical and structural abnormalities were involved in larynx cancer Hep-2.The total number of chromosomes ranging from tripolyploidy in passage187to more than that in passage207.The more frequent chromosomes involved in numerical aberrations were chromosomes1,7,16,17 and 18. Structural chromosomal aberrations were also detected.Deletion of short arm was detected in chromosome 1(

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5

Yang, Q., G. Yoshimura, I. Mori, T. Sakurai, and K. Kakudo. "Chromosome 3p and breast cancer." Journal of Human Genetics 47, no. 9 (2002): 453–59. http://dx.doi.org/10.1007/s100380200064.

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Riley, Jacquelyn D., Catherine M. Stefaniuk, Francine Erenberg, Angelika L. Erwin, Lauren Palange, and Caroline Astbury. "Chromosome 3p Inverted Duplication with Terminal Deletion: Second Postnatal Case Report with Additional Clinical Features." Case Reports in Genetics 2019 (July 25, 2019): 1–7. http://dx.doi.org/10.1155/2019/5384295.

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Distal deletions and duplications of 3p are individually well-characterized chromosome abnormalities. Here, we report an inverted duplication of 3p with an adjacent terminal 3p deletion in a 17-month-old girl who had prenatal intrauterine growth restriction and cardiac defects. Other findings included hemangiomas, neutropenia, umbilical hernia, hypotonia, gross motor delay, microcephaly, and ptosis. Family history was noncontributory. Microarray analysis revealed a 5.37 Mb deletion of chromosome bands 3p26.1 to 3p26.3 and a 13.68 Mb duplication of 3p24.3 to 3p26.1. FISH analysis confirmed that

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7

Tarkan-Argüden, Yelda, Seniha Hacihanefioglu, Gül Öngen, Müzeyyen Erk, and Asim Cenani. "3p Abnormalities in Peripheral Lymphocytes in Small Cell Lung Cancer." Tumori Journal 95, no. 4 (2009): 535–37. http://dx.doi.org/10.1177/030089160909500423.

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3p abnormalities are the most frequent chromosome abnormalities in small cell lung cancer (SCLC). To date these abnormalities have only been observed in cells derived from tumor tissues. It is thought that cancer-related chromosome abnormalities in peripheral lymphocytes could help to predict cancer development, prognosis, and future metastasis. We report clonal and nonclonal 3p abnormalities in the peripheral lymphocytes of two patients with SCLC. A standard T-lymphocyte culture method and GTL banding technique were applied to the samples, and various clonal and nonclonal chromosome 3 abnorma

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8

Grebe, Stefan K. G., Bryan McIver, Ian D. Hay, et al. "Frequent Loss of Heterozygosity on Chromosomes 3p and 17p without VHL or p53 Mutations Suggests Involvement of Unidentified Tumor Suppressor Genes in Follicular Thyroid Carcinoma1." Journal of Clinical Endocrinology & Metabolism 82, no. 11 (1997): 3684–91. http://dx.doi.org/10.1210/jcem.82.11.4352.

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Follicular thyroid carcinoma (FTC) exhibits frequent loss of heterozygosity (LOH) on chromosomes 10q and 3p, suggesting involvement of tumor suppressor genes. We screened 14 FTC (10 Hurthle cell carcinomas and 4 nonoxyphilic FTC), 14 papillary thyroid carcinomas, and 7 follicular adenomas for LOH on chromosome arms 1p, 3p, 3q, 10p, 10q, 11p, 11q, 13q, 17p, and 17q. LOH was more frequent in FTC than in follicular adenoma or papillary thyroid carcinoma. In FTC, rates of LOH on 3p (86%), 17p (72%), and 10q (57%) were higher than the average rate of LOH (33%; P &lt; 0.05). Most frequently invo

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9

Mallick, Samyukta, and Alison M. Taylor. "Abstract 1414: The role of chromosome arm 3p and human papillomavirus on proliferation, differentiation, and metastasis in squamous cancers." Cancer Research 83, no. 7_Supplement (2023): 1414. http://dx.doi.org/10.1158/1538-7445.am2023-1414.

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Abstract Squamous Cell Carcinoma (SCC) is an aggressive form of cancer that develops in the mucosal epithelium of the digestive and respiratory tracts as well as on the skin. Two major risk factors for development of SCC are carcinogen exposures, such as alcohol and tobacco, and Human Papillomavirus (HPV) infection. Viral- and carcinogen-driven SCCs have differential responses to radiation, chemotherapy, and immunotherapy, with HPV+ SCCs responding better to these treatments than HPV- carcinomas. Analysis of aneuploidy patterns of genomic samples from The Cancer Genome Atlas (TCGA) have shown

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10

Zhang, G. L., and K. L. Xu. "Loss of heterozygosity at chromosome 3p in epithelial ovarian cancer in China." International Journal of Gynecologic Cancer 12, no. 2 (2002): 198–201. http://dx.doi.org/10.1136/ijgc-00009577-200203000-00010.

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The aim of this investigation was to determine the relationship between 3p loss of heterozygosity (LOH) and the pathogenesis of ovarian cancer. Fifty cases of epithelial ovarian tumor, including 40 cases with malignant tumors and 10 cases with benign tumors, were examined by polymerase chain reaction (PCR) with D3s1228 and D3s1038 microsatellite polymorphism markers at 3p. Thirty-two of the 40 cases (80%) with ovarian cancer showed LOH at 3p14 or 3p25, but only 1 of 10 cases (10.0%) with benign ovarian tumor showed 3p LOH. Among them, 24 cases (60.0%) had LOH at 3p14 and 16 cases (40.0%) at 3p

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11

Sims, Karen, Roberto L. P. Mazzaschi, Emilie Payne, Ian Hayes, Donald R. Love, and Alice M. George. "A Rare Chromosome 3 Imbalance and Its Clinical Implications." Case Reports in Pediatrics 2012 (2012): 1–5. http://dx.doi.org/10.1155/2012/846564.

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The duplication of chromosome 3q is a rare disorder with varying chromosomal breakpoints and consequently symptoms. Even rarer is the unbalanced outcome from a parental inv(3) resulting in duplicated 3q and a deletion of 3p. Molecular karyotyping should aid in precisely determining the length and breakpoints of the 3q+/3p− so as to better understand a child’s future development and needs. We report a case of an infant male with a 57.5 Mb duplication from 3q23-qter. This patient also has an accompanying 1.7 Mb deletion of 3p26.3. The duplicated segment in this patient encompasses the known crit

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12

Pan, Chao-Yu, Wei-Ting Kuo, Chien-Yuan Chiu, and Wen-chang Lin. "Visual Display of 5p-arm and 3p-arm miRNA Expression with a Mobile Application." BioMed Research International 2017 (2017): 1–7. http://dx.doi.org/10.1155/2017/6037168.

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MicroRNAs (miRNAs) play important roles in human cancers. In previous studies, we have demonstrated that both 5p-arm and 3p-arm of mature miRNAs could be expressed from the same precursor and we further interrogated the 5p-arm and 3p-arm miRNA expression with a comprehensive arm feature annotation list. To assist biologists to visualize the differential 5p-arm and 3p-arm miRNA expression patterns, we utilized a user-friendly mobile App to display. The Cancer Genome Atlas (TCGA) miRNA-Seq expression information. We have collected over 4,500 miRNA-Seq datasets from 15 TCGA cancer types and furth

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13

Gijtenbeek, Johanna M. M., Bram Jacobs, Sandra H. E. Sprenger, et al. "Analysis of von Hippel—Lindau mutations with comparative genomic hybridization in sporadic and hereditary hemangioblastomas: possible genetic heterogeneity." Journal of Neurosurgery 97, no. 4 (2002): 977–82. http://dx.doi.org/10.3171/jns.2002.97.4.0977.

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Object. Hemangioblastomas (HBs) occur sporadically or as a manifestation of von Hippel—Lindau (VHL) disease. In the majority of VHL-related HBs, inactivation of the VHL tumor suppressor gene (TSG), which is located on chromosome 3p25–26, is found. The VHL gene is assumed to be involved also in the development of sporadic HBs. In a previous study of chromosomal aberrations of sporadic HBs, multiple chromosomal imbalances were found in the majority of tumors. The aim of this study was to analyze further both sporadic HBs and VHL-related HBs to determine if these histopathologically identical tum

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14

Naylor, Susan L., Angus Marshall, Bruce E. Johnson, et al. "Chromosome 3P in small cell lung cancer." Lung Cancer 4, no. 3-4 (1988): 117–20. http://dx.doi.org/10.1016/s0169-5002(88)80033-3.

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Amato, Eliana, Stefano Barbi, Giorgio Malpeli, et al. "Chromosome 3p alterations in pancreatic endocrine neoplasia." Virchows Archiv 458, no. 1 (2010): 39–45. http://dx.doi.org/10.1007/s00428-010-1001-x.

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Abdelwahed, M., R. Jackson, N. Yurtsever, et al. "Interstitial Duplication on Chromosome 3p14.3p13 in an Adolescent with Dysmorphic Features and Autism, Case Report." American Journal of Clinical Pathology 158, Supplement_1 (2022): S47—S48. http://dx.doi.org/10.1093/ajcp/aqac126.092.

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Abstract Introduction/Objective The genetic etiology of autism spectrum disorders is only partially understood. Here we describe a 16-year-old male diagnosed with autism at two years of age. He has dysmorphic features, severe cognitive disability, and history of cryptorchidism. A review of systems was significant for slightly coarse features overall, with deep-set eyes, pinched nasal bridge with wide nasal tip, and widely spaced teeth. A large pectus excavatum deformity was also noted. Although the parent’s genetic testing concluded that this likely represents de novo mutation, it is worth men

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17

Jee, Kowan J., Young Tak Kim, Kyu Rae Kim, Yan Aalto, and Sakari Knuutila. "Amplification at 9p in Cervical Carcinoma by Comparative Genomic Hybridization." Analytical Cellular Pathology 22, no. 3 (2001): 159–63. http://dx.doi.org/10.1155/2001/174645.

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DNA copy number changes were studied by comparative genomic hybridization on 10 tumor specimens of squamous cell carcinoma of cervix obtained from Korean patients. DNA was extracted from paraffin‐embedded sections after removal of non‐malignant cells by microdissection technique. Copy number changes were found in 8/10 tumors. The most frequent changes were chromosome 19 gains (n=6) and losses on chromosomes 4 (n=4), 5 (n=3), and 3p (n=3). A novel finding was amplification in chromosome arm 9p21‐pter in 2 cases. Gains in 1, 3q, 5p, 6p, 8q, 16p, 17, and 20q and losses at 2q, 6q, 8p, 9q, 10p, 11,

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18

Pellegrini, Sandra, Maria Ribeiro, Evelyn Kahn, et al. "Familial Study of Paracentric Inversion in Chromosome 3p." British Journal of Medicine and Medical Research 3, no. 3 (2016): 760–70. http://dx.doi.org/10.9734/bjmmr/2013/2170.

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Johansson, B., R. Billström, U. Kristoffersson, et al. "Deletion of chromosome arm 3p in hematologic malignancies." Leukemia 11, no. 8 (1997): 1207–13. http://dx.doi.org/10.1038/sj.leu.2400718.

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Walton, J. M., C. L. Y. Lee, E. Mikhail, J. P. Welch, and D. A. Gillis. "Unbalanced translocation of chromosome 3p in Wilms' tumor." Journal of Pediatric Surgery 27, no. 10 (1992): 1311–14. http://dx.doi.org/10.1016/0022-3468(92)90283-d.

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Todd, S., S. L. Naylor, H. A. Drabkin, and M. Gemmil. "Dinucleotide repeat polymorphism (D3S1776) on human chromosome 3p." Human Molecular Genetics 3, no. 5 (1994): 841. http://dx.doi.org/10.1093/hmg/3.5.841.

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Buchhagen, Dorothy L. "Frequent involvement of chromosome 3p alterations in lung carcinogenesis: Allelotypes of 215 established cell lines at six chromosome 3p loci." Journal of Cellular Biochemistry 63, S24 (1996): 198–209. http://dx.doi.org/10.1002/jcb.240630515.

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Sharma, Ankita, Umesh K. Shandilya, Tianna Sullivan, et al. "Identification of Ovine Serum miRNAs Following Bacterial Lipopolysaccharide Challenge." International Journal of Molecular Sciences 21, no. 21 (2020): 7920. http://dx.doi.org/10.3390/ijms21217920.

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Host–pathogen interactions are complex and influenced by host genetic and epigenetic modifications. Recently, the significance of microRNAs (miRNAs) in pathogenic infection and the regulation of immune response has been highlighted. However, information on miRNAs’ role in the course of inflammation is still very limited in small ruminants. The present study was intended to identify changes in the expression of circulatory miRNAs post-lipopolysaccharide (LPS)-challenge. In this study, young ewes (n = 18) were challenged with Escherichia coli LPS (400 ng/kg i.v.) and blood samples were collected

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24

Martin-de Saro, Monica, Zyndia Compean, Karina Aguilar, et al. "Partial Trisomy 13q/Monosomy 3p Resulting from a Paternal Reciprocal 3p;13q Translocation in a Boy with Facial Dysmorphism and Hypertrophic Cardiomyopathy." Molecular Syndromology 12, no. 5 (2021): 305–11. http://dx.doi.org/10.1159/000516058.

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Individuals with 3p deletion show a great clinical variability. Apparently, a 1.5-Mb terminal deletion, including the <i>CRBN</i> and <i>CNTN4</i> genes, is sufficient to cause this syndrome. Partial trisomy 13q is a rare chromosomal abnormality with a variable phenotypic expression, but in most cases, patients have a phenotype resembling complete trisomy 13. The aim of the present study is to describe a 9-month-old Mexican male patient with 3p deletion/13q duplication and a novel clinical finding. He presented with facial dysmorphism and multiple congenital alterations

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25

Zettl, Andreas, Silvia Bea, George Wright, et al. "Chromosomal Imbalances in Germinal Center B-Cell-Like and Activated B-Cell-Like Diffuse Large B-Cell Lymphoma Influence Gene Expression Signatures and Improve Gene Expression-Based Survival Prediction(the First Two Authors Contributed Equally to This Work)." Blood 104, no. 11 (2004): 415. http://dx.doi.org/10.1182/blood.v104.11.415.415.

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Abstract Introduction: Germinal center B-cell (GCB)-like and activated B-cell (ABC)-like diffuse large B-cell lymphomas (DLBCL) are characterized by different recurrent chromosomal imbalances. In a series of 177 untreated de novo DLBCL analyzed by comparative genomic hybridization (CGH), GCB-like DLBCL had shown more frequent gains of chromosome 12p/12cen-q14 (22% vs 5%, p=.0025), whereas ABC-like DLBCL had shown more frequent gains of 3/3q27-qter (34% vs 6%; p&lt;0.0001), 18q21 (36% vs 11%;p=0.0002) and losses of 6q21-q23 (36% vs 20%; p=0.0269). We investigated the impact of chromosomal i

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Zhakula-Kostadinova, Nadja, Sejal Jain, Laura Byron, Matthew L. Meyerson, and Alison M. Taylor. "Abstract PR016: Investigating vulnerabilities associated with chromosome arm aneuploidy in cancer." Molecular Cancer Therapeutics 23, no. 6_Supplement (2024): PR016. http://dx.doi.org/10.1158/1538-8514.synthleth24-pr016.

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Abstract Aneuploidy – loss or gain of whole chromosomes or chromosome arms, is rare and poorly tolerated in normal cells but occurs in ∼90% of solid tumors; however, the mechanisms through which specific aneuploidies affect cancer development are unclear. Additionally, generating mammalian models of specific chromosome arm alterations is technically difficult, limiting further study. Cancers have tumor, cell, and tissue type-specific patterns of chromosome arm copy-number alterations that influence tumor evolution and sensitivity to anti-cancer therapies. Squamous cell carcinomas (SCCs) affect

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Mariani-Costantinl, Renato, Giorgio Merlo, and Luigi Frati. "Genomic Alterations in Human Breast Cancer: A Review." Tumori Journal 75, no. 4 (1989): 311–20. http://dx.doi.org/10.1177/030089168907500404.

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We review and discuss data on the genetic alterations documented in human breast carcinomas at the molecular level. These alterations may result in: 1) deletion of genetic material (chromosome 11p, 13q, 3p, 1q, 17p); 2) amplification of genes or entire chromosomal segments (c-myc, c-erb-B2, locus DF3/PUM, loci on 11q13); 3) rearrangements (c-myc); 4) point mutations (c-ras). Presently available informations do not allow the development of cohesive pathogenetic models but indicate that the molecular basis of human breast cancer is heterogeneous.

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Gayrard, Nathalie, Valère Cacheux, François Iborra, Georges Mourad, and Àngel Argilés. "Cytogenetic Studies of 24 Renal Epithelial Tumors With von Hippel-Lindau and Fragile Histidine Triad Protein Expression Correlation." Archives of Pathology & Laboratory Medicine 132, no. 6 (2008): 965–73. http://dx.doi.org/10.5858/2008-132-965-csoret.

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Abstract Context.—Deletion of the short arm of chromosome 3 (3p deletion) is a cytogenetic abnormality generally associated with clear cell renal cell carcinoma, the most aggressive form of renal epithelial tumor. Objective.—To cytogenetically characterize 24 renal tumors in order to check the incidence and the type of 3p deletions, as well as to identify new genes putatively participating in renal tumorigenesis and test the protein products of the von Hippel-Lindau (VHL) and fragile histidine triad (FHIT) genes. Design.—We analyzed 24 renal tumors by conventional cytogenetics, comparative gen

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Zhakula, Nadja, Sejal Jain, Laura Byron, Joan J. Castellano, Matthew L. Meyerson, and Alison M. Taylor. "Abstract 2992: Uncovering metabolic dysregulation and therapeutic targets in aneuploid models of squamous cell carcinoma." Cancer Research 85, no. 8_Supplement_1 (2025): 2992. https://doi.org/10.1158/1538-7445.am2025-2992.

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Abstract Squamous cell carcinomas (SCCs) arise from epithelial tissues in the lung, head and neck, esophagus, bladder, and cervix. SCCs lack canonical oncogenic mutations and urgently need targeted therapies. Aneuploidy—chromosomal losses or gains, is rare and poorly tolerated in normal cells but occurs in 90% of tumors in tissue-specific patterns. SCCs are characterized by near-universal early chromosome 3p deletion and 3q gain, which correlate with poor prognosis and metastasis. To study effects of 3p deletion in human cells, we used CRISPR-Cas9 to delete a copy of 3p in human immortalized l

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Dini, Pouya, Hossam El-Sheikh Ali, Mariano Carossino, et al. "Expression Profile of the Chromosome 14 MicroRNA Cluster (C14MC) Ortholog in Equine Maternal Circulation throughout Pregnancy and Its Potential Implications." International Journal of Molecular Sciences 20, no. 24 (2019): 6285. http://dx.doi.org/10.3390/ijms20246285.

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Equine chromosome 24 microRNA cluster (C24MC), the ortholog of human C14MC, is a pregnancy-related miRNA cluster. This cluster is believed to be implicated in embryonic, fetal, and placental development. The current study aimed to characterize the expression profile of this cluster in maternal circulation throughout equine gestation. The expression profile of miRNAs belonging to this cluster was analyzed in the serum of non-pregnant (diestrus), pregnant (25 d, 45 d, 4 mo, 6 mo, 10 mo), and postpartum mares. Among the miRNAs examined, 11 miRNAs were differentially expressed across the analyzed

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Taylor, Alison Marie. "Abstract LE03-01: Functional and computational approaches to uncover selection advantages of cancer aneuploidy." Cancer Research 82, no. 12_Supplement (2022): LE03–01—LE03–01. http://dx.doi.org/10.1158/1538-7445.am2022-le03-01.

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Abstract Aneuploidy, including the gain or loss of whole chromosomes or chromosome arms, is a near-universal feature of cancer. We previously applied methods that define chromosome arm aneuploidy to over 10,000 tumors in the Cancer Genome Atlas (TCGA). Cancer subtypes are often characterized by tumor specific patterns of chromosome arm copy number alterations and breakpoints; for example, squamous cell carcinomas (SCCs) from different tissues of origin are characterized by chromosome 3p (chr3p) loss and chromosome 3q (chr3q) gain. From the TCGA aneuploidy data, we developed an algorithm called

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Asadi, Shahin. "A Comprehensive Review of Chromosome 3, Monosomy 3p Syndrome." American Journal of Biomedical Science & Research 21, no. 2 (2024): 137–40. http://dx.doi.org/10.34297/ajbsr.2024.21.002816.

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vd Berg, A., K. Kok, M. R. Seruca, J.-W. Oosterhuis, P. E. Postmus, and C. H. C. M. Buys. "The occurrence of chromosome 3p deletions in lung carcinoids." Cancer Genetics and Cytogenetics 52, no. 2 (1991): 232. http://dx.doi.org/10.1016/0165-4608(91)90501-k.

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Herzog, Christopher R., Keith A. Crist, Carol L. K. Sabourin, et al. "Chromosome 3p tumor-suppressor gene alterations in cervical carcinomas." Molecular Carcinogenesis 30, no. 3 (2001): 159–68. http://dx.doi.org/10.1002/mc.1024.

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Kim, Hugh Andrew Jinwook, Mushfiq Hassan Shaikh, Mark Lee, et al. "3p Arm Loss and Survival in Head and Neck Cancer: An Analysis of TCGA Dataset." Cancers 13, no. 21 (2021): 5313. http://dx.doi.org/10.3390/cancers13215313.

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Loss of the 3p chromosome arm has previously been reported to be a biomarker of poorer outcome in both human papillomavirus (HPV)-positive and HPV-negative head and neck cancer. However, the precise operational measurement of 3p arm loss is unclear and the mutational profile associated with the event has not been thoroughly characterized. We downloaded the clinical, single nucleotide variation (SNV), copy number aberration (CNA), RNA sequencing, and reverse phase protein assay (RPPA) data from The Cancer Genome Atlas (TCGA) and The Cancer Proteome Atlas HNSCC cohorts. Survival data and hypoxia

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Heerema, Nyla A., Gerard Lozanski, Thomas S. Lin, Molly Moran, Michael R. Grever, and John C. Byrd. "Cytogenetic Studies of 539 Chronic Lymphocytic Leukemia (CLL) Patients." Blood 106, no. 11 (2005): 1192. http://dx.doi.org/10.1182/blood.v106.11.1192.1192.

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Abstract Previous banded metaphase cytogenetic studies of CLL identified deletions of 13q, 11q, 17p and 6q and trisomy 12 as recurring aberrations; all except del(6q) have well-recognized prognostic significance. The association of other cytogenetic abnormalities with these recurring aberrations has not been previously described. To more completely characterize our patients with CLL, we performed banded metaphase cytogenetics and fluorescence in situ hybridization (FISH) on 539 patients with previously untreated as well as relapsed CLL. By banded metaphase analysis 236 cases were abnormal, 282

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Broad, T. E., D. J. Burkin, L. M. Cambridge, et al. "Six loci mapped on to human chromosome 2p are assigned to sheep chromosome 3p." Animal Genetics 26, no. 2 (2009): 85–90. http://dx.doi.org/10.1111/j.1365-2052.1995.tb02638.x.

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Whitney, Michael, Matt Thayer, Carol Reifsteck, et al. "Microcell mediated chromosome transfer maps the Fanconi anaemia group D gene to chromosome 3p." Nature Genetics 11, no. 3 (1995): 341–43. http://dx.doi.org/10.1038/ng1195-341.

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Qingjuan, Liu, Feng Xiaojuan, Zhang Wei, et al. "miR-148a-3poverexpression contributes to glomerular cell proliferation by targeting PTEN in lupus nephritis." American Journal of Physiology-Cell Physiology 310, no. 6 (2016): C470—C478. http://dx.doi.org/10.1152/ajpcell.00129.2015.

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The objective of this study was to investigate the role of miR-148a-3p in lupus nephritis (LN) based on data from previous studies and a microRNA assay. We evaluated the miR-148a-3p expression level in LN renal tissues and blood serum to determine its clinicopathological significance and effect on glomerular cell proliferation. Then, we collected renal glomeruli from LN mice and determined the miR-148a-3p, proliferating cell nuclear antigen (PCNA), and PCNA/Thy1 expression. We performed functional analyses of miR-148a-3p in vitro and in vivo. We also investigated the target gene of miR-148a-3p

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40

Yuan, Bo, Mengyun Zou, Yabo Zhao, Kang Zhang, Yingfei Sun та Xiuli Peng. "Up-Regulation of miR-130b-3p Activates the PTEN/PI3K/AKT/NF-κB Pathway to Defense against Mycoplasma gallisepticum (HS Strain) Infection of Chicken". International Journal of Molecular Sciences 19, № 8 (2018): 2172. http://dx.doi.org/10.3390/ijms19082172.

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Mycoplasma gallisepticum (MG) is the pathogen of chronic respiratory disease (CRD), hallmarked by vigorous inflammation in chickens, causing the poultry industry enormous losses. miRNAs have emerged as important regulators of animal diseases. Previous miRNA sequencing data has demonstrated that miR-130b-3p is up-regulated in MG-infected chicken embryo lungs. Therefore, we aimed to investigate the function of miR-130b-3p in MG infection of chickens. RT-qPCR results confirmed that miR-130b-3p was up-regulated both in MG-infected chicken embryo lungs and chicken embryonic fibroblast cells (DF-1 c

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41

Klampfl, Thorsten, Ashot Harutyunyan, Tiina Berg, et al. "Genome integrity of myeloproliferative neoplasms in chronic phase and during disease progression." Blood 118, no. 1 (2011): 167–76. http://dx.doi.org/10.1182/blood-2011-01-331678.

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Abstract Philadelphia chromosome–negative myeloproliferative neoplasms (MPNs) are clonal myeloid disorders with increased production of terminally differentiated cells. The disease course is generally chronic, but some patients show disease progression (secondary myelofibrosis or accelerated phase) and/or leukemic transformation. We investigated chromosomal aberrations in 408 MPN samples using high-resolution single-nucleotide polymorphism microarrays to identify disease-associated somatic lesions. Of 408 samples, 37.5% had a wild-type karyotype and 62.5% harbored at least 1 chromosomal aberra

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Zara, F., M. Labuda, P. Gaetano Garofalo, et al. "Unusual EEG pattern linked to chromosome 3p in a family with idiopathic generalized epilepsy." Neurology 51, no. 2 (1998): 493–98. http://dx.doi.org/10.1212/wnl.51.2.493.

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Objective: To map the gene causing an unusual EEG pattern of delta bursts that appears to segregate as an autosomal dominant trait in an Italian family. The EEG pattern was observed in four family members affected by idiopathic generalized epilepsy (IGE) and in six other clinically unaffected members.Methods: All available family members underwent clinical and EEG examination. DNA samples were obtained and used to perform a whole-genome scan with 270 microsatellite markers. After the first linked marker was identified, 12 additional markers in the same chromosomal region were tested to confirm

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43

Klatte, Tobias, P. Nagesh Rao, Michela de Martino, et al. "Cytogenetic Profile Predicts Prognosis of Patients With Clear Cell Renal Cell Carcinoma." Journal of Clinical Oncology 27, no. 5 (2009): 746–53. http://dx.doi.org/10.1200/jco.2007.15.8345.

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Purpose The majority of cytogenetic studies in renal cell carcinoma (RCC) have been impaired by small sample size, retrospective character, and lack of a survival end point. We prospectively studied the prognostic impact of cytogenetic abnormalities on a larger cohort of patients having up to 108 months of follow-up. Patients and Methods Tumors of 282 patients who underwent nephrectomy for clear cell RCC were cytogenetically analyzed. Results were correlated with pathological factors and disease-specific survival. Results The most frequently observed cytogenetic abnormalities were loss of 3p (

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Natera-de Benito, Daniel, M. Asunción García-Pérez, Miguel Ángel Martínez-Granero, and Luis Izquierdo-López. "A patient with a duplication of chromosome 3p (p24.1p26.2): A comparison with other partial 3p trisomies." American Journal of Medical Genetics Part A 164, no. 2 (2013): 548–50. http://dx.doi.org/10.1002/ajmg.a.36164.

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Mohamed, Anwar N., Gail Bentley, Michelle L. Bonnett, Margareta Palutke, and Ayad M. Al-Katib. "Cytogenetic Abnormalities in Histologically Confirmed Multiple Myeloma." Blood 106, no. 11 (2005): 5082. http://dx.doi.org/10.1182/blood.v106.11.5082.5082.

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Abstract In multiple myeloma, conventional cytogenetics is limited by low proliferation activity of plasma cells in culture. Despite that, nonrandom chromosomal abnormalities have been reported in one third of cases. Recently, the karyotype has emerged as an important prognostic factor in multiple myeloma. In this study, we identified 104 histologically confirmed multiple myeloma cases with satisfactory cytogenetic evaluation and abnormal karyotype. FISH analysis was used to evaluate certain chromosome abnormalities or to monitor treatment response. Hyperdiploid karyotype was found in 67 cases

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Li, X., T. W. Rosahl, T. C. Südhof, and U. Francke. "Mapping of synapsin II (SYIM2) genes to human chromosome 3p and mouse chromosome 6 bandF." Cytogenetic and Genome Research 71, no. 3 (1995): 301–5. http://dx.doi.org/10.1159/000134132.

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Hermsen, Mario, Marta Alonso Guervós, Gerrit Meijer, et al. "Chromosomal Changes in relation to Clinical Outcome in Larynx and Pharynx Squamous Cell Carcinoma." Analytical Cellular Pathology 27, no. 3 (2005): 191–98. http://dx.doi.org/10.1155/2005/407216.

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Invasive head and neck squamous carcinomas are among the cytogenetically most complex tumors. Perhaps for this reason, there is little consensus on the prognostic value of specific chromosomal aberrations. Here we present Results of CGH analysis of 56 clinically well-characterized set of head and neck cancers, consisting of larynx and pharynx only. The aim was to find possible associations with clinical outcome. The major chromosome arms showing gains were (in decreasing order): 3q, 7q, 8q, 5p, 11q13, 17q and 18p, and losses occurred at 3p, 11qter, 4p, 18q, and 5q. The segments most frequently

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van Nederveen, Francien H., Esther Korpershoek, Ronald J. deLeeuw, et al. "Array-comparative genomic hybridization in sporadic benign pheochromocytomas." Endocrine-Related Cancer 16, no. 2 (2009): 505–13. http://dx.doi.org/10.1677/erc-08-0241.

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Pheochromocytomas (PCC) are catecholamine-producing tumors arising from the adrenal medulla that occur either sporadically or in the context of hereditary cancer syndromes, such as multiple endocrine neoplasia type 2 (MEN2), von Hippel-Lindau disease (VHL), neurofibromatosis type 1, and the PCC-paraganglioma syndrome. Conventional comparative genomic hybridization studies have shown loss of 1p and 3q in the majority of sporadic and MEN2-related PCC, and 3p and 11p loss in VHL-related PCC. The development of a submegabase tiling resolution array enabled us to perform a genome-wide high-resoluti

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Lounis, Hafida, Anne-Marie Mes-Masson, France Dion, et al. "Mapping of chromosome 3p deletions in human epithelial ovarian tumors." Oncogene 17, no. 18 (1998): 2359–65. http://dx.doi.org/10.1038/sj.onc.1202152.

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Tsui, Ivy F. L., Miriam P. Rosin, Lewei Zhang, Raymond T. Ng, and Wan L. Lam. "Multiple Aberrations of Chromosome 3p Detected in Oral Premalignant Lesions." Cancer Prevention Research 1, no. 6 (2008): 424–29. http://dx.doi.org/10.1158/1940-6207.capr-08-0123.

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