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Artykuły w czasopismach na temat „Chronic Acne”

Autor: Grafiati

Data publikacji: 2 czerwca 2025

Data aktualizacji: 31 lipca 2025

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1

Ionescu, Marius-Anton A., M. Feuiolley, J. Enault, P. Wolkenstein, G. Robert, and L. Lefeuvre. "Acne, the microbiome and innate immunity." Russian Journal of Skin and Venereal Diseases 19, no. 5 (2016): 279–82. http://dx.doi.org/10.18821/1560-9588-2016-19-5-279-282.

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In the laste years several articles focalized on human microbioma - the microorganisms from skin, mucosae, bowel - and on its role in chronic inflammatory diseases of the skin as acne, rosacea, atopic dermatitis, seborrheic dermatitis. In this article the authors present an update on particular acne skin’s microbioma, on innate immunity in acne and new physiopathology mecanisms described in inflammatory process in acne, and at the end we present in vitro, ex vivo and in vivo studies on the microbioma modulation and microbiofilm of pathogenic ribotypes of P. acnes leading to a significant impro

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Febyan and Wetarini Krisnhaliani. "Acne Vulgaris in Adults: A Brief Review on Diagnosis and Management." International Journal of Research and Review 7, no. 5 (2020): 246–52. https://doi.org/10.5281/zenodo.3938621.

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Acne vulgaris is a chronic skin disease with an inflammatory condition of the skin affecting the pilosebaceous glands. Four concepts of pathogenesis lead to the formation of acne vulgaris, such as sebum production, follicular skin, microbial colonization by Propionibacterium acnes bacteria, and inflammatory mediators. The diagnosis of acne vulgaris is dependent on the identification of lesions using classification from the American Academy Dermatology. Acne management is exceptionally diverse, including monotherapy or a combination of various agents that have a role in suppressing the anti-inf

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Dong, Wenshan. "A Review of the Pathogenic Mechanisms of Propionibacterium Acnes in Acne." Theoretical and Natural Science 103, no. 1 (2025): 54–59. https://doi.org/10.54254/2753-8818/2025.22921.

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Acne is a common chronic inflammatory skin disease that primarily affects adolescents and young adults, with an incidence rate exceeding 80% in this population. Its pathogenesis is complex and multifactorial, involving excessive sebaceous gland secretion, inflammation, and infection, etc. Among them, Propionibacterium acnes (P. acnes) is considered one of the key pathogenic factors. This paper reviews recent domestic and international research on the pathogenic mechanisms of P. acnes in acne, with a detailed discussion on its biological characteristics, its role in acne pathogenesis, and its i

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4

Zhao, Chenyu. "Explore the influence of circadian clock on acne." Theoretical and Natural Science 65, no. 1 (2024): 177–81. https://doi.org/10.54254/2753-8818/2024.la18221.

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Acne is a disease which have some stimulate compound secret on our face surface or other parts of our body. Acne is a chronic inflammatory skin disease that affects the sebaceous gland units of the skin, characterized by open and closed comedones, papules, pustules, and cysts. It impacts nearly 50 million individuals in the United States. Its pathogenesis involves follicular hyper-keratinization, inflammation, in part generated by Cutibacterium acnes (formerly Proprionibacterium acnes) and hormonal alterations acne. The circadian clock was shown to be strongly correlated. As a natural rhythm i

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Leignadier, Julie, Marie Drago, Olivier Lesouhaitier, et al. "Lysine-Dendrimer, a New Non-Aggressive Solution to Rebalance the Microbiota of Acne-Prone Skin." Pharmaceutics 15, no. 8 (2023): 2083. http://dx.doi.org/10.3390/pharmaceutics15082083.

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Acne is a chronic inflammatory skin disease that affects the quality of life of patients. Several treatments exist for acne, but their effectiveness tends to decrease over time due to increasing resistance to treatment and associated side effects. To circumvent these issues, a new approach has emerged that involves combating the pathogen Cutibacterium acnes while maintaining the homeostasis of the skin microbiome. Recently, it was shown that the use of a G2 lysine dendrigraft (G2 dendrimer) could specifically decrease the C. acnes phylotype (IAI) involved in acne, compared to non-acne-causing

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Athanasopoulou, Sophia, Eleni Panagiotidou, Eleni Spanidi, et al. "Propolis Extract with Activity Against Cutibacterium acnes Biofilm Targeting the Expression of Virulence Genes." Antioxidants 14, no. 7 (2025): 849. https://doi.org/10.3390/antiox14070849.

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Acne is a highly prevalent skin condition with multifactorial pathophysiology, where Cutibacterium acnes (C. acnes) overgrowths generate inflammation. C. acnes can grow and adhere, through the formation of biofilms, to almost any surface, which enables chronic infections. Acne treatment with antibiotics can induce topical antimicrobial resistance, impair microbiome biodiversity and cause cutaneous dysbiosis. In this study, we assess the effect of a standardized propolis extract (PE) from Greece against C. acnes, whilst maintaining skin’s microbiome biodiversity, and we investigate its effect a

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7

Li, Xiwei. "Research progress in the treatment of acne." Theoretical and Natural Science 16, no. 1 (2023): 17–24. http://dx.doi.org/10.54254/2753-8818/16/20240508.

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Acne is widely distributed globally, especially prevalent among adolescents and adults, and is one of the most common skin diseases clinically. Research has found that acne is a common chronic skin disease involving the sebaceous gland unit, and its pathogenesis involves multiple factors such as genetics and metabolism, including infection of Propionibacterium acnes, overactivation of sebaceous glands, abnormal follicular keratinization, and enhanced inflammatory response. Currently, topical drug therapy, systemic drug therapy, phototherapy, and chemical peel therapy have gained consensus in t

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8

Popa, Gabriela Loredana, Cristina Iulia Mitran, Madalina Irina Mitran, et al. "Markers of Oxidative Stress in Patients with Acne: A Literature Review." Life 13, no. 7 (2023): 1433. http://dx.doi.org/10.3390/life13071433.

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Acne vulgaris is a chronic inflammatory skin disease of the pilosebaceous unit. Its pathogenesis is multifactorial and involves the overlap between four main processes: alteration of the keratinization, increased sebum production, colonization with Cutibacterium acnes, and inflammation. The role of oxidative stress (OS) has been intensively studied in inflammatory skin conditions such as psoriasis, vitiligo, or atopic dermatitis. However, the involvement of OS in the pathogenesis of acne is less known. The evidence accumulated over the last decade suggests that in the case of acne patients, th

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9

Kruglova, Larisa S., Natalia V. Gryazeva, and Anait V. Tamrazova. "Skin Microbiota Content in Children and its Effect on Acne Pathogenesis." Current Pediatrics 20, no. 5 (2021): 430–34. http://dx.doi.org/10.15690/vsp.v20i5.2319.

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Acne is a common chronic inflammatory skin disease in adolescence. The involvement of cosmetically important zones inevitably leads to decrease in our patients' quality of life. This review considers modern methods of skin microbiota analysis, describes the microorganisms' composition in newborns and its changes during growing-up. Cutibacterium acnes (that dominates in the microbiota of skin areas with sebaceous glands) role in acne pathogenesis is described.

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10

Lasota, Nina, Gabriela Demidowicz, Natalia Trąbka, et al. "Acne is a medical and social problem." Journal of Education, Health and Sport 38, no. 1 (2023): 277–93. http://dx.doi.org/10.12775/jehs.2023.38.01.019.

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Acne is one of the most common dermatoses. It is a chronic inflammatory disease of pilosebaceous units. The pathogenesis of the disease consists of: hyperproliferation of hair follicle opening cells and the formation of microcomedones closing its opening. Excessive activity of the sebaceous glands and increased sebum production. Inflammatory reaction induced by Cutibacterium acnes. Acne most often occurs between the ages of 11 and 30. Acne changes affect adults more and more often. Statistically, the incidence of acne vulgaris is comparable, but more severe course is more common in men. The mo

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11

Ionescu, Marius-Anton, Alin Laurentiu Tatu, Camelia Busila, et al. "Microbiome Modulation in Acne Patients and Clinical Correlations." Life 14, no. 6 (2024): 688. http://dx.doi.org/10.3390/life14060688.

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Background: The imbalance of skin microbiota in acne can induce changes leading to induction or to aggravation of chronic inflammatory lesions; complex mechanisms are involved. Cutibacterium acnes (C. acnes) ribotypes RT4 and RT5 express more biofilm and are associated with inflammatory acne lesions. C. acnes RT6 is a non-acne ribotype, beneficial for the skin. Objectives: In an open clinical trial, acne adults were included and assessed clinically at baseline and at month 2 using the Investigator Global Assessment of Acne (IGA) score. A topical emulsion was applied twice daily for 2 months (M

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12

Li, Xu, Wenyan Ding, Zicheng Li, et al. "vB_CacS-HV1 as a Novel Pahexavirus Bacteriophage with Lytic and Anti-Biofilm Potential against Cutibacterium acnes." Microorganisms 12, no. 8 (2024): 1566. http://dx.doi.org/10.3390/microorganisms12081566.

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Acne vulgaris is a prevalent chronic inflammatory skin disease, most common in adolescence and often persisting into adulthood, leading to severe physical and psychological impacts. The primary etiological factor is Cutibacterium acnes infection. The overuse of antibiotics for acne treatment over recent decades has led to the emergence of antibiotic-resistant Cutibacterium acnes strains. In this study, we isolated and characterized a novel bacteriophage, vB_CacS-HV1, from saliva samples. The average nucleotide identity analysis indicated that vB_CacS-HV1 is a new species within the Pahexavirus

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13

Balapadang, Rachel Noveriachristie, Aldila Divana Sarie, Safira Rosyidah, Iqbal Zulqifli, Muthia Nur Akifah, and Aliya Azkia Zahra. "Formulation and Evaluation of Transdermal Dissolving Microneedle Loaded with Ethanol Extract of Cocor Bebek Leaves (Kalanchoe pinnata)." JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA 11, no. 3 (2024): 378–85. https://doi.org/10.20473/jfiki.v11i32024.378-385.

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Background: Acne is a chronic skin inflammation caused by blockage of the sebaceous glands in the skin and hypercolonization of the acne-causing bacteria Propionibacterium acnes. Cocor bebek leaves (Kalanchoe pinnata) are known to contain various secondary metabolites, including flavonoids, with antibacterial activity. Objective: In an effort to prevent side effects from using oral and topical antibiotics to treat acne, an alternative acne treatment that is safer and more effective with a strong drug delivery system is needed: microneedle patch technology containing natural ingredients. Method

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Nituporna, Bora, and Devi Jutirani. "A Comprehensive Survey on Models Used for Acnegenesi." International Journal of Dermatology and Clinical Research 10, no. 1 (2024): 005–12. https://doi.org/10.17352/2455-8605.000051.

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Acne vulgaris is a widespread chronic inflammatory skin illness that is primarily caused by inflammation, irregular skin cell turnover inside hair follicles, increased sebum production, and Propionibacterium acnes bacterial overgrowth. This comprehensive overview examines the intricate causes of acne vulgaris. The paper highlights the significant role of genetic predisposition, hormonal fluctuations, and environmental factors in acne development. Various in vivo and in vitro models, including mouse ear edema, rat models, and advanced techniques like 3D bioprinting and organ-on-a-chip systems,

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15

Kuo, Chi-Wen, Yi-Fang Chiu, Min-Hua Wu, et al. "Gelatin/Chitosan Bilayer Patches Loaded with Cortex Phellodendron amurense/Centella asiatica Extracts for Anti-Acne Application." Polymers 13, no. 4 (2021): 579. http://dx.doi.org/10.3390/polym13040579.

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Acne is a chronic inflammatory skin disease that often occurs with anaerobic Propionibacterium acnes (P. acnes). Anti-acne patches, made of hydrocolloid or hydrogel, have become a popular way of topical treatment. The outer water-impermeable layer of commercial patches might create hypoxic conditions and promote P. acnes growth. In this study, gelatin/chitosan (GC) bilayer patches were prepared at different temperatures that included room temperature (RT), −20 °C/RT, and −80 °C/RT. The most promising GC bilayer patch (−80 °C /RT) contained a dense upper layer for protection from bacteria and i

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16

Harshal, Kuhite Sanjana Nishad* Dr. V. S. Babu Agala. "The Efficacy of Apple Cider Vinegar in Treating Acne Vulgaris: Review of Literature." International Journal of Pharmaceutical Sciences 3, no. 4 (2025): 732–39. https://doi.org/10.5281/zenodo.15165653.

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Acne vulgaris is a chronic inflammatory disease that affects the hair follicle, sebaceous gland, and surrounding structures. It primarily occurs in adolescents but can persist into adulthood, impacting around 650 million people globally. Acne is influenced by genetic, hormonal, and environmental factors, with Propionibacterium acnes playing a key role in its development by promoting keratinocyte hyperproliferation, excessive sebum production, and inflammation. Apple cider vinegar (ACV), made from fermented apple juice, has gained popularity as a potential natural acne treatment due to its acet

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Khunteta, Alok, Amit Kumar Sharma, Surendra Kumar Swarnkar, Deepa Gupta, and Puneet Gupta. "Formulation and Evaluation of Polyherbal Gel Containing Fruits Extract of Terminalia Chebula and Phyllanthus Emblica for Treatment of Acne." Journal of Drug Delivery and Therapeutics 15, no. 7 (2025): 56–63. https://doi.org/10.22270/jddt.v15i7.7278.

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Acne vulgaris is a common, chronic inflammatory condition that affects the pilosebaceous units. Conventional treatments often pose side effects and resistance issues, prompting interest in safer, plant-based alternatives. To develop and evaluate a polyherbal anti-acne gel incorporating hydroalcoholic extracts of Terminalia chebula and Phyllanthus emblica, targeting the antimicrobial and anti-inflammatory pathways associated with acne. Hydroalcoholic extracts of the selected plants were prepared and subjected to phytochemical screening and quantification of total phenolic and flavonoid contents

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18

Chilicka, Karolina, Iwona Dzieńdziora-Urbińska, Renata Szyguła, Binnaz Asanova, and Danuta Nowicka. "Microbiome and Probiotics in Acne Vulgaris—A Narrative Review." Life 12, no. 3 (2022): 422. http://dx.doi.org/10.3390/life12030422.

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Acne vulgaris is a chronic disease characterised by the appearance of eruptions such as whiteheads, blackheads, pustules, papules, and cysts. Among factors that cause acne vulgaris are the abnormal keratinisation of the sebaceous canal, bacterial colonisation (Cutibacterium acnes), increased sebum production, genotypic factors, and hormonal disorders. Treatment is often long and tedious, and can lead to a reduction in quality of life and social isolation. The intestinal microbiota is greatly important in the formation of acne lesions. It is also responsible for the proper immunity of the organ

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Yulinar Maulida and M. Mimbar Topik. "Penanganan Acne Vulgaris Terkini." Termometer: Jurnal Ilmiah Ilmu Kesehatan dan Kedokteran 2, no. 3 (2024): 98–111. http://dx.doi.org/10.55606/termometer.v2i3.4072.

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Acne Vulgaris (AV) is a chronic inflammatory skin disorder in the pilosebaceous unit. This condition generally manifests as papules, pustules, or nodules especially on the face and can also affect the upper arms, trunk and back. AV is ideopathic, but can also be caused by increased sebum production, hyperkeratinization of hair follicles, colonies of Propionibacterium acnes (P. acnes) bacteria and inflammatory processes. Some of these causes are related to risk factors as triggers, such as food factors, use of cosmetics, and psychological stress. AV is one of the most common dermatological cond

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Nakyai, Wongnapa, Wachirachai Pabuprapap, Wichuda Sroimee, Vachiraporn Ajavakom, Boon-ek Yingyongnarongkul, and Apichart Suksamrarn. "Anti-Acne Vulgaris Potential of the Ethanolic Extract of Mesua ferrea L. Flowers." Cosmetics 8, no. 4 (2021): 107. http://dx.doi.org/10.3390/cosmetics8040107.

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Acne vulgaris is a common chronic inflammatory skin disease. In the present study, we reported the anti-acne vulgaris effect of the Mesua ferrea (M. ferrea) flower extract. The extract was evaluated for three anti-acne-causing bacteria properties including Cutibacterium acnes (C. acnes), Staphylococcus epidermidis (S. epidermidis) and Staphylococcus aureus (S. aureus). The results indicated that the M. ferrea flower extract could be considered as the bactericidal agent against S. epidermidis and S. aureus with MIC values of 0.78 and 6.25 mg mL−1 and MBC values of 1.56 and 12.50 mg mL−1 and the

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Jiang, Shan, Xiaoyan Peng, Yan Chen, Bingqi Dong та Hu Mao. "Fucoxanthin ameliorates Propionibacterium acnes-induced ear inflammation in mice by modulating the IκBα/NF-κB signaling pathway and inhibiting NF-κB nuclear translocation". PLOS One 20, № 5 (2025): e0322950. https://doi.org/10.1371/journal.pone.0322950.

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Background Acne vulgaris, a chronic inflammatory skin disorder, represents a pivotal research area in dermatology. Although fucoxanthin, a marine-derived carotenoid, displays potent anti-inflammatory activity, its therapeutic potential in acne pathogenesis remains underexplored. Objective This study investigates fucoxanthin’s effects on Propionibacterium acnes (P.acnes)-induced auricular inflammation in mice, focusing on its modulation of the IκBα/NF-κB signaling axis and inhibition of NF-κB nuclear translocation. Methods Inflammation in the ear of mice was induced using a P.acnes injection mo

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Nishigandha Naresh Choudhari, Anshu Rupesh Dudhe, Sanika Pundlik Tatte, et al. "Formulation and evaluation of anti-acne face cream." World Journal of Advanced Research and Reviews 19, no. 1 (2023): 1181–88. http://dx.doi.org/10.30574/wjarr.2023.19.1.1419.

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Now a day’s the majority of Indians are affected by the persistent skin illness known as acne vulgaris. Sebaceous glands are involved in the chronic inflammatory skin condition known as acne. Propionibacterium acnes (P. acne), altered follicular keratinization, inflammation, and androgen-induced enhanced sebum hyper-production are four primary pathophysiology. Due to their minimal adverse effects, many now prefer using herbal products over synthetic ones. We create the anti-acne face cream using ingredients like Manjishtha, Aloe Vera, and almond oil. Indian madder, also known as Rubia cordifol

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Nishigandha, Naresh Choudhari, Rupesh Dudhe Anshu, Pundlik Tatte Sanika, et al. "Formulation and evaluation of anti-acne face cream." World Journal of Advanced Research and Reviews 19, no. 1 (2023): 1181–88. https://doi.org/10.5281/zenodo.10303308.

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Now a day's the majority of Indians are affected by the persistent skin illness known as acne vulgaris. Sebaceous glands are involved in the chronic inflammatory skin condition known as acne. <i>Propionibacterium acnes</i> (P. acne), altered follicular keratinization, inflammation, and androgen-induced enhanced sebum hyper-production are four primary pathophysiology. Due to their minimal adverse effects, many now prefer using herbal products over synthetic ones. We create the anti-acne face cream using ingredients like Manjishtha, Aloe Vera, and almond oil. Indian madder, also known as Rubia c

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Yim, Mi-Jin, Jeong Min Lee, Hyun-Soo Kim, et al. "Inhibitory Effects of a Sargassum miyabei Yendo on Cutibacterium acnes-Induced Skin Inflammation." Nutrients 12, no. 9 (2020): 2620. http://dx.doi.org/10.3390/nu12092620.

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Acne vulgaris is a chronic inflammatory condition of skin sebaceous follicles. To explore its effects on acne vulgaris, we investigated the antibacterial and anti-inflammatory activities of Sargassum miyabei Yendo (a brown alga) ethanolic extract (SMYEE) on Cutibacterium acnes (C. acnes)-stimulated inflammatory responses, both in vivo and in vitro. To induce inflammation in vivo, C. acnes was intradermally injected into the dorsal skin of mice, to which SMYEE was applied. The antimicrobial activity of SMYEE was evaluated by the determination of minimum inhibitory concentrations (MICs). To expl

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Silvia, Eka, Ringgo Alfarisi, Arief Effendi, and Muhammad Alva Rizqy. "Efektifitas Antibiotik Azelaic Acid Terhadap Propioni-Baktterium Acne Dengan Metode Difusi Pada Pasien Acne Vulgaris." MAHESA : Malahayati Health Student Journal 2, no. 3 (2022): 586–97. http://dx.doi.org/10.33024/mahesa.v2i3.6428.

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ABSTRACT Acne vulgaris is a form of chronic inflammation of the hair follicles of the sebaceous glands in the form of multifactorial and clinical manifestations of acne, papules, pustules, lymph nodes, and cysts. Propionibacterium acnes is a bacterium involved in acne inflammation and Azelaic acid is one of the acne vulgaris treatments that have antimicrobial and anti-inflammatory effects. Know the degree of effectiveness of Azelaic Acid antibiotic against propionibacterium acne by in vitro diffusion method and compare it with several antibiotics (clindamycin, erythromycin, benzoyl peroxide, t

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Yolanda, Maya Oktari, Nelva Karmila Jusuf, and Imam Budi Putra. "Lower facial skin hydration level increases acne vulgaris severity level." Bali Medical Journal 10, no. 3 (2021): 1081–84. http://dx.doi.org/10.15562/bmj.v10i3.2195.

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Backgrounds: Acne vulgaris is a chronic sebaceous gland inflammatory disorder that predominantly affects adolescents and young adults. Increased sebum, alterations in follicular keratinization, Cutibacterium acnes colonization, and inflammation are the critical pathways in the pathogenesis of acne vulgaris. Facial skin hydration can affect the primary pathogenesis mechanism of acne vulgaris. This study aimed to examine the correlation between the level of facial skin hydration and the severity of acne vulgaris. Methods: This study was an observational analytical study of 40 subjects with acne

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Sonyot, Witsanu, Supaporn Lamlertthon, Janet Jennifer Luangsa-ard, et al. "In Vitro Antibacterial and Anti-Inflammatory Effects of Novel Insect Fungus Polycephalomyces phaothaiensis Extract and Its Constituents against Propionibacterium acnes." Antibiotics 9, no. 5 (2020): 274. http://dx.doi.org/10.3390/antibiotics9050274.

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Propionibacterium acnes plays an important role in the pathophysiology of acne vulgaris, the most common chronic inflammatory skin disease of the pilosebaceous unit. This study was conducted to investigate whether the entomopathogenic fungus Polycephalomyces phaothaiensis components have antibacterial and anti-inflammatory effects against P. acnes that may serve for acne treatment. A chemical study by spectroscopic analysis resulted in the identification of seven known compounds. The anti-P. acnes potency of extracts and test compounds was determined by both agar diffusion and broth dilution m

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Grange, Philippe A., Guillaume Ollagnier, Laurianne Beauvais Remigereau, et al. "A New Topical Candidate in Acne Treatment: Characterization of the Meclozine Hydrochloride as an Anti-Inflammatory Compound from In Vitro to a Preliminary Clinical Study." Biomedicines 10, no. 5 (2022): 931. http://dx.doi.org/10.3390/biomedicines10050931.

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Acne is a chronic inflammatory multifactorial disease involving the anaerobic bacterium Cutibacterium acnes (C. acnes). Current acne treatments are associated with adverse effects, limiting treatment compliance and use. We showed that meclozine, an anti-histaminic H1 compound, has anti-inflammatory properties. In Vitro, meclozine reduced the production of CXCL8/IL-8 and IL-1β mRNA and protein by C. acnes-stimulated human keratinocytes and monocytes. No cell toxicity was observed at the IC50. Meclozine prevented the phosphorylation of ERK and JNK. In Vivo, 1% meclozine gel significantly decreas

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Farhah, Amelia, and Siti Mardiyanti. "Uji Aktivitas Antibakteri Ekstrak Etanol Sabut Kelapa (Cocos nucifera Linn.) Terhadap Bakteri Cutibacterium acnes." Jurnal Farmasi dan Farmakoinformatika 2, no. 2 (2024): 76–88. http://dx.doi.org/10.35760/jff.2024.v2i2.9732.

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Cutibacterium acnes is the main bacteria that causes acne. Acne is a skin infection that is common and often complained about. Acne is an obstructive skin disease and chronic inflammation of the pilosebaceous glands, which is characterized by the appearance of comedones, papules, pustules and nodules. Treatment of acne can be done with the help of antibiotics. However, continuous use of antibiotics can cause resistance. This study aims to test the antibacterial activity by using natural ingredients, namely ethanol extract of coconut husk (Cocos nucifera L.) against Cutibacterium acnes. The stu

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Ely, Aprilia Fatma, Shelly Taurhesia, and Teti Indrawati1. "ANTIBACTERIAL EFFECTIVENESS (Propionibacterium acnes) OF KOMBUCHA FACE TONER FORMULA WITH GREEN TEA LEAF (Camellia sinensis L.)." Medical Sains : Jurnal Ilmiah Kefarmasian 8, no. 3 (2023): 1101–12. http://dx.doi.org/10.37874/ms.v8i3.809.

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Acne is a process of chronic inflammation of the sebaceous glands in the skin caused by the bacteria Propionibacterium acnes. Approximately 80-100% incidence of acne occurs in adolescents. One solution is to use an antibacterial agent called catechins. It can be easily obtained from green tea, which has high catechin content. The amount of catechins used as antibacterial substances in green tea can also be increased by fermentation. In addition, lactic acid-fermented green tea can inhibit the growth of P. acnes. This study aimed to produce green tea kombucha face toner with anti-acne activity

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Sandhya Sahu, Janki Sahu, and Tiltoma Sahu. "Polyherbal approaches to acne treatment: Natural solution." International Journal of Science and Research Archive 13, no. 2 (2024): 2821–30. https://doi.org/10.30574/ijsra.2024.13.2.2455.

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Acne is a chronic inflammatory condition of the pilosebaceous unit caused by androgen-induced changes in keratinization, inflammation, and sebum production. It often affects the face, back, and chest due to clogged hair follicles from oil, dead skin cells, and bacterial colonization, primarily by Propionibacterium acnes. Hormonal changes during adolescence, family history, and possibly early P. acnes colonization contribute to its development. While dietary factors have been suggested, evidence remains inconclusive. Acne affects 9.4% of the global population and is particularly prevalent among

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Nurzyńska-Wierdak, Renata, Dominika Pietrasik, and Magdalena Walasek-Janusz. "Essential Oils in the Treatment of Various Types of Acne—A Review." Plants 12, no. 1 (2022): 90. http://dx.doi.org/10.3390/plants12010090.

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Acne is a chronic, common disease that poses a significant therapeutic, psychological and social problem. The etiopathogenesis of this disease is not fully understood. Drugs used in general and external therapy should have anti-seborrhoeic, anticomadogenic, bactericidal, bacteriostatic, and anti-inflammatory properties. Acne treatment is often associated with the long-term use of antibiotics, contributing to the global antibiotic resistance crisis. In order to solve this problem, attention has been paid to essential oils and their terpene components with potent antimicrobial, anti-inflammatory

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Yadav, Samiksha, and Mansi Gupta. "Formulation and Evaluation of Anti-Acne Herbal Face Wash Gel." Journal of Drug Delivery and Therapeutics 9, no. 4 (2019): 523–25. http://dx.doi.org/10.22270/jddt.v9i4.3096.

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Acne is a chronic inflammatory disorder of pilosebaceous unit, which involves increased sebum production by sebaceous glands and abnormal desquamation of hair follicles occur in response to increasing androgen levels with the onset of puberty. Obstruction of follicles causes follicular distention which is often accompanied by the proliferation of the bacteria Propionibacterium acnes and the activation of an inflammatory response. The present work aimed to prepare the face wash gel containing Thai herbal extract.The plants have been reported in the literature having good anti-microbial, anti-ox

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Singh, Monika, and Dikshant Shri. "Insulin resistance in moderate to severe acne vulgaris." Indian Journal of Dermatology 67, no. 2 (2022): 205. http://dx.doi.org/10.4103/ijd.ijd_396_21.

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Introduction: Acne vulgaris is a chronic inflammatory disease of the pilosebaceous unit usually affects adolescents. It is seen on the face, neck, trunk and arms. The main pathogenic factors of acne are high sebaceous gland secretion, follicular hyper proliferation, high androgen effects, propionibacterium acnes colonization and inflammation. Objectives: To determine the presence of insulin resistance in moderate to very severe acne vulgaris. Material and Methods: One hundred sixty subjects were enrolled in the study consisting of 80 patients with moderate to very severe acne vulgaris and 80 a

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Yaswanthi, Reddy K., Shree Shruthi, Y. Poojitha, and C. H. Kallappa. "Acne Vulgaris: Association with Metabolic Syndrome." International Journal of Pharmaceutical and Clinical Research 16, no. 2 (2024): 1568–71. https://doi.org/10.5281/zenodo.11083883.

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<strong>Introduction:</strong> Acne vulgaris is a chronic inflammatory disease of pilosebaceous unit resulting in lesions like comedones, papules, pustules, nodules. It is mainly caused due to androgen dependant sebum production and propiobacterium acnes proliferation. Metabolic syndrome is a cluster of condition that increases the risk of heart disease, stroke, and diabetes. Analysing the association of acne vulgaris with metabolic syndrome (MetS) is the primary aim of this study. <strong>Methods:</strong> This is a cross sectional study of 40 cases of acne vulgaris and 40 cont

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Verma, Navneet Kumar, Asheesh Kumar Singh, Ajay Maurya, Ambesh Rai, and Amit kumar Chaurasiya. "A Brief Review on Acne Vulgaris: Chronic Inflammatory Disease." Middle East Research Journal of Pharmaceutical Sciences 3, no. 1 (2023): 5–10. http://dx.doi.org/10.36348/merjps.2023.v03i01.002.

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Acne vulgaris (AV) is a chronic inflammatory disease rather than a natural part of the life cycle as colloquially viewed of the pilosebaceous unit (comprising the hair follicle, hair shaft and sebaceous gland) and is among the most common dermatological conditions worldwide. Some of the key mechanisms involved in the development of acne include disturbed sebaceous gland activity associated with hyperseborrhoea (that is, increased sebum production) and alterations in sebum fatty acid composition, dysregulation of the hormone microenvironment, interaction with neuropeptides, follicular hyperkera

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Susilo, Rut Indah, Ali Napiah Nasution, and Maya Sari Mutia. "Effectiveness of mahkota dewa leaves extract as a biofilm inhibitor of propionibacterium acnes growth." Jurnal Teknologi Laboratorium 12, no. 1 (2023): 4–13. http://dx.doi.org/10.29238/teknolabjournal.v12i1.393.

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Acne vulgaris is a chronic inflammation of the pilosebaceous unit with various clinical manifestations caused by bacterial colonization of Propionibacterium acnes. Various studies have been performed to improve the modality of acne vulgaris therapy with natural product, such as leaves of Mahkota Dewa (Phaleria macrocarpa). This experimental study aims to investigate the effect of the Mahkota Dewa leaves extract against P. acnes by using Disc Diffusion method and Inhibition of Biofilm formation. Research results showed that the Total Flavonoid and Tannin content were 953.10 mg QE/gr DW and 42.6

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Thiboutot, Diane M., and Donald P. Lookingbill. "Acne: Acute or chronic disease?" Journal of the American Academy of Dermatology 32, no. 5 (1995): S2—S5. http://dx.doi.org/10.1016/0190-9622(95)90414-x.

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Vargas, Elga Jhoanna, Julio Cesar Martinez, and Lina Andrea Gomez. "Use of Plasma-Rich in Growth Factors (PRGF) in the Treatment of Acne." OBM Transplantation 08, no. 04 (2024): 1–5. http://dx.doi.org/10.21926/obm.transplant.2404225.

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Acne is a chronic inflammatory condition affecting the pilosebaceous units of the skin, characterized by the formation of papules, cysts, comedones, pustules, nodules, and scars. These lesions are typically located on the face and shoulders, although they can extend to the trunk, arms, and legs. In regenerative medicine, biomolecules are fundamental to tissue regeneration. The use of growth factors from autologous platelet-rich plasma emerges as a promising alternative in the treatment of acne and scars. This study aimed to describe the case of a patient with moderate papulopustular acne treat

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Nawarathne, Nirmani Wishwakala, Kanchana Wijesekera, Gaya Bandara Wijayaratne, and Mayuri Napagoda. "Development of novel topical cosmeceutical formulations with antimicrobial activity against acne-causing microorganisms from <em>Coriandrum sativum</em> L." Journal of Science 14, no. 1 (2023): 1–17. http://dx.doi.org/10.4038/jsc.v14i1.60.

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Spices possess a diverse array of natural phytochemicals with antibacterial, anti-inflammatory, and antioxidant effects. Hence spices could be employed to treat chronic dermatologic conditions like acne vulgaris which involves infection of Propionibacterium acnes and Staphylococcus aureus, and inflammation. Particularly with the emergence of antibiotic resistance, there is an utmost necessity for the development of novel therapeutic agents for the management of acne. Thus, this study was focused on the development of novel topical gel formulations from the seeds of Coriandrum sativum L. (coria

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Shraddha, Pandurang Tandale* ¹. Shrikant Hanumant Gosavi1 Mohini Raghunath Suryawanshi1 Pooja Wankhede2. "Formulation And Evaluation Of Polyherbal Cream In Acne Treatment." International Journal in Pharmaceutical Sciences 2, no. 8 (2024): 2980–86. https://doi.org/10.5281/zenodo.13293845.

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Acne is commonly known as multifactorial chronic inflammatory disease of pilosebaceous units. Bacteria that contributes to causing acne are Propionibacterium acnes and Staphylococcus epidermidis Acne occurs at any age mainly in adolescents. Propionibacterium acnes and Staphylococcus epidermidis cause pus in acne resulting in inflammation   In the market, there are varierty of anti-acne topical preparation are available, such as topical creams, gels & patches. The herbal formulation has various advantages over synthetic formulation.        &

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Aubin, Guillaume Ghislain, Da Silva Grâce Ada, Yoshinobu Eishi, et al. "Immune discrepancies during in vitro granuloma formation in response to Cutibacterium (formerly Propionibacterium ) acnes infection." Anaerobe 48 (December 1, 2017): 172–76. https://doi.org/10.1016/j.anaerobe.2017.08.014.

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Cutibacterium (formerly Propionibacterium) acnes is involved in chronic/low-grade pathologies such as sarcoidosis or prosthetic joint infection (PJI). In these diseases, granulomatous structures are frequently observed. In this study, we induced a physiological granulomatous reaction in response to different wellcharacterized clinical C. acnes isolates in order to investigate the cellular process during granuloma formation. Three C. acnes isolates selected according to their origin (PJI, sarcoidosis and acne) were typed by MLST. All C. acnes isolates generated granulomatous structures in our e

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Agak, George, Yang Yu, Min Qin, et al. "Silencing of IL-17 modulates inflammatory and antimicrobial defense responses mediated by Propionibacterium acnes (HUM7P.291)." Journal of Immunology 192, no. 1_Supplement (2014): 184.8. http://dx.doi.org/10.4049/jimmunol.192.supp.184.8.

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Abstract Inflammation resulting from immune responses targeting Propionibacterium acnes plays a significant role in acne pathogenesis. We demonstrate that IL-17-expressing cells are present in skin biopsies from acne patients, and that P. acnes is a potent inducer of Th17-related cytokines, including IL-17 (inflammatory) and IL-22 (antimicrobial defense and tissue repair). Here we investigated whether silencing of IL-17 and IL-22 modulates Th17-related inflammatory and antimicrobial responses mediated by P. acnes. P. acnes stimulated peripheral blood mononuclear cells (PBMCs) demonstrated elev

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Matushevskaya, E. V., E. V. Vladimirova, and Yu I. Matushevskaya. "The use of a combination drug with adapalene/metronidazole for acne." Meditsinskiy sovet = Medical Council, no. 14 (September 27, 2023): 17–22. http://dx.doi.org/10.21518/ms2023-249.

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The latest advances in the research of the effect of skin microbiome on the occurrence of acne raised the need for the development of new effective treatments for the long-term use in persistent or recurrent disease. The review presents an analysis of foreign and domestic studies on the issues of pathogenesis and treatment of acne. The latest data on the role of skin microbiome imbalance in the occurrence of acne are presented. The Cutibacterium acnes phylotypes diversity loss acts as a trigger for innate immunity activation and chronic inflammation in acne. We show the main directions in the

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Ivanova, Kristina, Eva Ramon, Aleksandra Ivanova, Susana Sanchez-Gomez, and Tzanko Tzanov. "Bio-Based Nano-Enabled Cosmetic Formulations for the Treatment of Cutibacterium Acnes-Associated Skin Infections." Antioxidants 12, no. 2 (2023): 432. http://dx.doi.org/10.3390/antiox12020432.

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Acne is a common chronic skin condition with serious physical and psychosocial consequences. In some cases, the appearance of pimples, whiteheads, or blackheads on the face, neck, and back may lead to scarring, disfiguring, depression, frustration, and anxiety in patients. Current treatments rely on antibiotics to eradicate Cutibacterium acnes (C. acnes), the bacterium responsible for this skin condition. However, these approaches do not scavenge the reactive oxidative species (ROS) generated during disease development and raise concerns about the increase in antimicrobial resistance. In this

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Amuzescu, Andreea, Mircea Tampa, Clara Matei, and Simona Roxana Georgescu. "Adult Female Acne: Recent Advances in Pathophysiology and Therapeutic Approaches." Cosmetics 11, no. 3 (2024): 74. http://dx.doi.org/10.3390/cosmetics11030074.

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Adult acne is a chronic inflammatory disease of the pilosebaceous unit characterized by the excessive production of abnormal sebum favoring an imbalance of the skin microbiota and the hyperproliferation of Cutibacterium acnes and other virulent microbial strains, leading to an inflammatory environment, innate immunity overactivation, and keratinocyte hyperproliferation in hair follicles pores. Degraded keratinocytes plug the pores, consequently forming microcomedons, which can later evolve to papules, nodules, pustules and scars. Distinct from juvenile acne, in adult female acne (AFA) the symp

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Nazarenko, A. R., N. N. Potekaev, A. N. Lvov, N. L. Klyachko, and A. G. Majouga. "Role of matrix metalloproteinases in acne inflammation: pathogenesis, diagnosis, treatment, prognosis." Medical alphabet, no. 9 (June 25, 2021): 24–28. http://dx.doi.org/10.33667/2078-5631-2021-9-24-28.

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Modern therapeutic views on the pathogenesis of acne indicate the role of permanent inflammation and expand the arsenal of medicines and combined techniques necessary for the successful treatment of this chronic skin disease. The complex process of immune inflammation in acne with the participation of pro-inflammatory cytokines is due to the interaction of trigger factors and factors of innate immunity. It was found that C. acne is able to interact with markers of increased immunity, such as Toll-like and protease-activated receptors. Based on a detailed analysis of the literature in search sy

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Bungau, Alexa Florina, Andrei-Flavius Radu, Simona Gabriela Bungau, et al. "Emerging Insights into the Applicability of Essential Oils in the Management of Acne Vulgaris." Molecules 28, no. 17 (2023): 6395. http://dx.doi.org/10.3390/molecules28176395.

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The occurrence of pustules, comedones, nodules, and cysts defines acne vulgaris, a prevalent chronic inflammatory dermatological condition. In the past few decades, essential oils extracted from varied natural sources have acquired recognition due to their potential medicinal applications in acne therapy. However, there is not yet sufficient medical data to fully characterize this interaction. Multiple factors contribute to the development of acne vulgaris, including excessive sebaceous production, inflammatory processes, hyperkeratinization, and infection with Cutibacterium acnes. Essential o

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Faruga-Lewicka, Wioleta, and Marek Kardas. "The role of vitamin D, omega acids, antioxidants, berberine, probiotics, lactoferrin and inositol in acne." Farmacja Polska 78, no. 11 (2023): 667–72. http://dx.doi.org/10.32383/farmpol/162806.

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Introduction and objective Acne vulgaris is a common, chronic and inflammatory skin disease of the folliculopilosebaceous unit. According to the literature, acne affects 85% adolescents and 50% adulthood, with an increasing tendency. The symptoms of acne are skin lesions such as comedones, pustules, papules as well as nodules and they generally appear on face, shoulders, chest and back. Based on its severity acne can be divided into following categories: mild, moderate and severe. The pathogenesis of acne is multivariate. Significant importance is attributed to hormonal changes, the role of Cu

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Carballido, F., A. Philippe, M. Maitre, et al. "A dermocosmetic product containing the sap of oat plantlets and Garcinia mangostana extract improves the clinical signs of acne." Journal of the European Academy of Dermatology and Venereology 38, S7 (2024): 12–20. http://dx.doi.org/10.1111/jdv.19876.

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AbstractBackgroundAcne vulgaris is a common chronic inflammatory disorder of the pilosebaceous unit, characterized by papules, pustules and/or nodules manifesting primarily on the face and/or upper back that can leave scars, post‐inflammatory hyperpigmentation (PIH) and erythema (PIE).ObjectiveTo evaluate the anti‐inflammatory properties of a protein‐free sap extruded from Rhealba® oat plantlets and a Garcinia mangostana extract on Cutibacterium acnes‐induced inflammation in vitro and assess the tolerability and efficacy of a dermocosmetic product containing these actives in subjects with mild

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