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1

Zhai, Savage, Qiu, Jin, Valdes-Rodriguez, and Mollanazar. "Chronic Pruritus Responding to Dupilumab—A Case Series." Medicines 6, no. 3 (2019): 72. http://dx.doi.org/10.3390/medicines6030072.

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Background: Chronic pruritus is defined as itch lasting for greater than six weeks. Pruritus is a burdensome manifestation of several internal and external disease states with a significant impact on quality of life. Dupilumab has shown promise in treating a number of conditions including atopic dermatitis (AD) and asthma. Its success in reducing pruritus in AD has generated interest regarding its potential application in other pruritic conditions, such as chronic pruritus of unknown origin, uremic pruritus, and pruigo nodularis. Methods: In this retrospective analysis, we present a series of
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Tareen, Attiya, Irfan Ullah, Ammara Safdar, Hadia Yaqub Khan, Uzma Rajar, and Habiba Yaqub Khan. "Generalized Pruritus: An Etiological Breakup of 700 patients presenting to dermatology opd of a local hospital." BMC Journal of Medical Sciences 3, no. 2 (2023): 65–69. https://doi.org/10.70905/bmcj.03.02.049.

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Background: Pruritus is an itching sensation or a constant urge to itch over skin that may be localized in response to a local stimulus or generalized due to an underlying condition with or without presence of causative agent. It can be caused by dermatological or systemic conditions, iatrogenic or as a response to external substances such as parasites. Generalized pruritus may not be necessarily due to dermatological causes and systemic, neurologic, endocrinologic, and psychogenic conditions may have pruritus as a primary cutaneous manifestation. Skin conditions like Scabies, eczema and airbo
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Yosipovitch, Gil, and Jeffrey D. Bernhard. "Chronic Pruritus." New England Journal of Medicine 368, no. 17 (2013): 1625–34. http://dx.doi.org/10.1056/nejmcp1208814.

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Ghassan, Ban, Jaffar N. Jaffar Alalsaidissa, Ali J. Hashim Al-Saedi, and Sabah N. Alawchi. "Relationship of Pruritus with Biochemical and Haematological Parameters in Haemodialysis Patients (A Single Center Study)." Journal of the Faculty of Medicine Baghdad 57, no. 4 (2016): 306–11. http://dx.doi.org/10.32007/jfacmedbagdad.574396.

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Background: Pruritus often constitutes a major problem for patients with end stage renal disease. The pathophysiological mechanism of chronic kidney disease -associated pruritus is poorly defined.Objectives: To evaluate the prevalence of uremic pruritus in dialysis patients and their correlation with the laboratory and clinical parameters in some Iraqi patients with chronic renal disease.Patients & methods: This analytic, descriptive, cross-sectional study was performed on 103 patients on haemodialysis. Blood urea, creatinine, calcium, phosphorus, alkaline phosphatase and parathyroid hormo
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Kupsa, Romana, Alexandra Gruber-Wackernagel, Angelika Hofer, Franz Quehenberger, Peter Wolf, and Franz J. Legat. "Narrowband-ultraviolet B vs Broadband-ultraviolet B in Treatment of Chronic Pruritus: A Randomized, Single-blinded, Non-inferiority Study." Acta Dermato-Venereologica 103 (June 26, 2023): adv9403. http://dx.doi.org/10.2340/actadv.v103.9403.

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Narrowband-ultraviolet B has shown increased efficacy over broadband-ultraviolet B in pruritic skin diseases, such as psoriasis and atopic dermatitis. In patients with chronic pruritus, e.g. in end-stage renal disease, broadband-ultraviolet B is recommended, but narrowband-ultraviolet B has also shown efficacy in reducing pruritus. This randomized, single blinded, non-inferiority study investigated the effects of narrowband-ultraviolet B compared with broadband-ultraviolet B. Patients with chronic pruritus were treated with either broadband- or narrowband-UVB 3 times a week for 6 weeks and cli
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Haq, Mazhar Ul, Rahmat Ali Khan, Najamud Din, Raza Muhammad Khan, and Sultan Zafar. "The Epidemiology of Chronic Kidney Disease-Related Pruritus and its Effect with Sleep Quality in Hemodialysis Patients in Pakistan A Cross-Sectional Study." Pakistan Journal of Medical and Health Sciences 16, no. 8 (2022): 957–59. http://dx.doi.org/10.53350/pjmhs22168957.

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A glomerular filtration rate of less than 60 ml/min/1.73 m2 for more than three months is the medical definition of chronic kidney disease (CKD) caused by damaged kidneys. The incidence of chronic kidney disease, which can be fatal if left untreated, has been rising for the past 30 years. An unpleasant condition, Pruritus due to chronic renal disease causes itching and decreases the quality of sleep. This study aims to examine the factors associated with Pruritus in CKD patients on maintenance hemodialysis and their impact on sleep quality. Duration and Place: Since 01/01 2019 and ending in 30
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Smith, Payton. "Treating Chronic Pruritus: Are We at the Threshold of a Breakthrough?" SKIN The Journal of Cutaneous Medicine 8, no. 4 (2024): 1711–13. http://dx.doi.org/10.25251/skin.8.4.11.

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Chronic pruritis, characterized by persistent itchiness lasting more than six weeks, affects up to 15% of the population, significantly impairing quality of life. Despite its prevalence and impact, there is an absence of FDA-approved medications specifically for the treatment of chronic pruritus, highlighting a significant unmet need in dermatology. Advancements in dermatologic medications, however, including the development of biologics and Janus kinase (JAK) inhibitors, signal potential breakthroughs in pruritus management through a radically different mechanism of action that focuses on the
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Yokoyama, Tomoaki. "Chronic Generalized Pruritus." New England Journal of Medicine 386, no. 6 (2022): e12. http://dx.doi.org/10.1056/nejmicm2114503.

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Smucker, Joanne, Louis Portas, and Joslyn S. Kirby. "Overevaluating Chronic Pruritus." JAMA Internal Medicine 175, no. 6 (2015): 895. http://dx.doi.org/10.1001/jamainternmed.2015.1041.

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Ishii, N., T. Nishiyama, Y. Sugita, H. Nakajima, and I. Aoki. "Pruritic papular eruption of the acquired immunodeficiency syndrome." Acta Dermato-Venereologica 74, no. 3 (1994): 219–20. http://dx.doi.org/10.2340/0001555574221223.

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We report a case of acquired immunodeficiency syndrome with pruritic papular eruption. The patient, a hemophiliac, presented with generalized pruritic, skin-colored papules and nodules. The chronic lesions were excoriated and hyper-pigmented. The eosinophil count was elevated, but IgE was normal. The lesions and pruritus responded only to ultraviolet B phototherapy. While the mechanism is not known, ultraviolet B phototherapy may provide relief of AIDS-related pruritus.
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Ain, Qurat Ul, Muhammad Sheheryar Asghar, Mohiuddin Saleem, Sana Majeed, Rubab Rameez, and Sidra Shaukat. "Incidence of Chronic Kidney Disease Related Pruritus and its Relation with Sleep Quality among Patients on Hemodialysis in Pakistan." Pakistan Journal of Medical and Health Sciences 16, no. 2 (2022): 1165–67. http://dx.doi.org/10.53350/pjmhs221621165.

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Due to injured kidneys, CKD is defined as a glomerular filtration rate of less than 60ml/min/1.73m2 for more than 3 months. The lethal stage of chronic CKDs is the last stage of renal disease, and its frequency has increased over the previous 30 years. Pruritus caused by chronic renal disease is an unpleasant illness that causes itching and reduces sleep quality. The goal of this study is to look at the characteristics of pruritus in people with CKD and how they relate with sleep quality among patients on maintenance hemodialysis. Place and Duration: In the department of Medicine & Nephrol
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Nyoman, Suryawati, and Swastika Adiguna Made. "Chronic pruritus in atopic dermatitis." International Journal of Medical Reviews and Case Reports 3, no. 5 (2019): 221–26. https://doi.org/10.5455/IJMRCR.chronic-pruritus-atopic-dermatitis.

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Atopic dermatitis (AD) is an inflammatory skin disease which characterized by chronic recidive skin rash and accompanied by complaints of pruritus. Chronic pruritus is reported to occur in 87-100% of AD patients and often affecting patient's quality of life. Management of chronic pruritus with antihistamines in AD is often ineffective, thus different pruritogens are considered to undergone the histamine-independent itch pathway.
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Ferreira, Bárbara R., and Laurent Misery. "Psychopathology Associated with Chronic Pruritus: A Systematic Review." Acta Dermato-Venereologica 103 (August 22, 2023): adv8488. http://dx.doi.org/10.2340/actadv.v103.8488.

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There are no previous studies of the psychopathology associated with different aetiologies of chronic pruritus. A systematic review was performed of cohort and case-control studies comparing healthy controls with patients with chronic pruritus related to primary dermatoses, systemic diseases, psychogenic pruritus, idiopathic pruritus, prurigo nodularis and/or lichen simplex chronicus. The review was registered in PROSPERO and performed according to the PRISMA statement, which allowed the inclusion of 26 studies. The quality of eligible studies was assessed using the modified Newcastle-Ottawa S
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14

Kandyil, Roshini, Nadia S. Satya, and Robert A. Swerlick. "Chronic Pruritus Associated with Helicobacter Pylori." Journal of Cutaneous Medicine and Surgery 6, no. 2 (2002): 103–8. http://dx.doi.org/10.1177/120347540200600202.

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Background: Helicobacter pylori is an established cause of gastritis and has been implicated in extradigestive diseases. Objective: To investigate the role of H. pylori in patients with unexplained refractory pruritus. Methods: Ten patients with severe pruritus unresponsive to conventional therapy were evaluated for active H. pylori infection by H. pylori serology followed by either esophagogastroduodenoscopy (EGD) or urea breath test. Of the 10 patients, 8 were found to have active infection. All 10 received anti- H. pylori antibiotic therapy and were reevaluated for relief of pruritus. Resul
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15

Damayanti. "Pruritus in elderly: Classification and management." World Journal of Advanced Research and Reviews 21, no. 1 (2024): 254–59. http://dx.doi.org/10.30574/wjarr.2024.21.1.2637.

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Pruritus is majority complaint that is often encountered in dermatology. The diagnosis and management of pruritus still became important health problem in elderly. It is estimated that one fifth of the world’s population experience chronic pruritus which can affect their quality of life. The lifetime prevalence of chronic pruritus in the general population was 22%. In the elderly, two thirds of the population are reported to experience pruritus. Based on the onset of symptom, pruritus is divided into acute pruritus and chronic pruritus. While based on clinical complaints, pruritus is divided i
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Damayanti. "Pruritus in elderly: Classification and management." World Journal of Advanced Research and Reviews 21, no. 1 (2024): 254–59. https://doi.org/10.5281/zenodo.13142144.

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Pruritus is majority complaint that is often encountered in dermatology. The diagnosis and management of pruritus still became important health problem in elderly. It is estimated that one fifth of the world’s population experience chronic pruritus which can affect their quality of life. The lifetime prevalence of chronic pruritus in the general population was 22%. In the elderly, two thirds of the population are reported to experience pruritus. Based on the onset of symptom, pruritus is divided into acute pruritus and chronic pruritus. While based on clinical complaints, pruritus is div
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Pereira, Manuel P., Sabine Steinke, Philipp Bruland, et al. "Management of chronic pruritus." Itch 2, no. 2 (2017): e6. http://dx.doi.org/10.1097/itx.0000000000000006.

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Калганова, А. Н., and А. П. Музыченко. "Differential Diagnosis of Chronic Pruritus." Дерматовенерология Косметология 9, no. 3 (2023): 291–95. http://dx.doi.org/10.34883/pi.2023.9.3.016.

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В статье представлены литературные данные по хроническому зуду, описаны основная классификация зуда, трудности диагностики и предложен диагностический алгоритм. Освещены критерии дифференциального диагноза хронического зуда. The article presents the literature review on chronic pruritus, describes the main classification of pruritus and diagnostic difficulties, proposes diagnostic algorithm. The criteria for the differential diagnosis of chronic pruritus are covered in detail.
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Bhalerao, Angeline, and Gurdeep S. Mannu. "Management of Pruritus in Chronic Liver Disease." Dermatology Research and Practice 2015 (2015): 1–5. http://dx.doi.org/10.1155/2015/295891.

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Background.There continues to be uncertainty on the ideal treatment of pruritus in chronic liver disease. The aim of this study was to gather the latest information on the evidence-based management of pruritus in chronic liver disease.Methodology.A literature search for pruritus in chronic liver disease was conducted using Pubmed and Embase database systems using the MeSH terms “pruritus,” “chronic liver disease,” “cholestatic liver disease,” and “treatment.”Results.The current understanding of the pathophysiology of pruritus is described in addition to detailing research into contemporary tre
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Garcovich, Simone, Martina Maurelli, Paolo Gisondi, Ketty Peris, Gil Yosipovitch, and Giampiero Girolomoni. "Pruritus as a Distinctive Feature of Type 2 Inflammation." Vaccines 9, no. 3 (2021): 303. http://dx.doi.org/10.3390/vaccines9030303.

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Pruritus is a common symptom of several skin diseases, both inflammatory and neoplastic. Pruritus might have a tremendous impact on patients’ quality of life and strongly interfere with sleep, social, and work activities. We review the role of type-2 inflammation and immunity in the pathogenesis of chronic pruritic conditions of the skin. Type 2 cytokines, including IL-4, IL-13, thymic stromal lymphopoietin, periostin, IL-31, IL-25, and IL-33 are released by mast cells, innate lymphoid cells 2, keratinocytes, and type 2 T lymphocytes, and are master regulators of chronic itch. These cytokines
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Panahi, Yunes, Amirhossein Sahebkar, Shahram Parvin, and Alireza Saadat. "A randomized controlled trial on the anti-inflammatory effects of curcumin in patients with chronic sulphur mustard-induced cutaneous complications." Annals of Clinical Biochemistry: International Journal of Laboratory Medicine 49, no. 6 (2012): 580–88. http://dx.doi.org/10.1258/acb.2012.012040.

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Background Chronic cutaneous complications such as pruritus are among the very frequent complaints of sulphur mustard (SM)-exposed patients. The present trial investigated the impact of curcumin on serum inflammatory biomarkers and their association with pruritus severity and quality of life (QoL). Methods This was a randomized, double-blind trial among 96 male Iranian veterans (age 37–59 y) who were suffering from chronic SM-induced pruritic skin lesions. Patients were randomly assigned to curcumin (1 g/d, n = 46) or placebo ( n = 50) for four weeks. Serum concentrations of interleukins 6 (IL
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Lu, Ping-Hsun, Chien-Cheng Lai, I.-Hsin Lin, Fu-Ming Tsai, and Po-Hsuan Lu. "Clinical Efficacy and Safety of Chinese Herbal Medicine in the Treatment of Uremic Pruritus: A Meta-Analysis of Randomized Controlled Trials." Pharmaceuticals 15, no. 10 (2022): 1239. http://dx.doi.org/10.3390/ph15101239.

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Uremic pruritus is a disturbing and refractory symptom in patients with advanced chronic kidney disease. Chinese herbal medicine has been reported to alleviate uremic pruritus. To investigate the effects of Chinese herbal medicine, we conducted a systematic review and meta-analysis on patients with uremic pruritus. We searched databases (prior to 3 May 2022) for randomized controlled trials on the effects of Chinese herbal medicine in treating uremic pruritus. Our meta-analysis included 3311 patients from 50 randomized controlled trials. In patients with uremic pruritus, adjunctive Chinese her
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Ryoo, Ji Hoon, Seon Hwa Lee, Dae-Lyong Ha, et al. "Validation of Relationship between Patients’ Descriptions of Pruritus and Patient-burden of Chronic Pruritus using Structural Equation Modelling." Acta Dermato-Venereologica 102 (November 24, 2022): adv00819. http://dx.doi.org/10.2340/actadv.v102.2527.

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Patients with chronic itch describe their pruritus in a wide variety of ways. However, these subjective descriptions are often not taken into consideration by physicians. This study aimed to validate patients’ descriptions of pruritus, and to investigate the relationship between various descriptions of pruritus and the patient burden of chronic pruritus by examining the mediating effects of sleep disturbance and sexual dysfunction on patient’s quality of life, as predicted by various descriptions of pruritus. Exploratory and confirmatory factor analyses were performed to identify the factor st
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Harvey, Naomi, Peter Craigon, Stephen Shaw, Sarah Blott, and Gary England. "Behavioural Differences in Dogs with Atopic Dermatitis Suggest Stress Could Be a Significant Problem Associated with Chronic Pruritus." Animals 9, no. 10 (2019): 813. http://dx.doi.org/10.3390/ani9100813.

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Canine atopic dermatitis (cAD) is a common allergic skin condition in dogs that causes chronic pruritus. The overall quality of life in dogs with cAD is known to be reduced, and human patients with pruritic conditions report significant psychological burdens from pruritus-induced stress, and atopic dermatitis is associated with significant psychopathological morbidities. We tested the hypothesis that dogs with cAD would display more problem behaviours that could be indicative of stress than would healthy controls. Behavioural data were gathered directly from owners using a validated dog behavi
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Adhikari, Laxman, Rajat Kayastha, and Karuna Bhatta. "Prevalence of uremic pruritus in chronic kidney patients undergoing maintenance hemodialysis at Kathmandu Medical College Teaching Hospital." Journal of Kathmandu Medical College 5, no. 4 (2017): 124–27. http://dx.doi.org/10.3126/jkmc.v5i4.18610.

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Background: Uremic pruritus is a common and troublesome symptom of chronic kidney disease. It is one of the dominant dermatological manifestations of chronic kidney disease which affects the quality of life of patients.Objective: To assess the prevalence and severity of uremic pruritus in chronic kidney disease patients undergoing maintenance hemodialysis.Methodology: A prospective cross-sectional study was done over three months among chronic kidney patients undergoing maintenance hemodialysis to show the association of mineral bone disorders with uremic pruritus. Patients complaining of prur
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Sari, Dede Wita Juwita Wulan. "OAT Lotion Reduces Itching Sensation Due to Pruritus in Hemodialysis Patients." Journal of Complementary Nursing 1, no. 3 (2022): 84–90. http://dx.doi.org/10.53801/jcn.v1i3.47.

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Background: Hemodialysis is the most commonly used renal replacement therapy for chronic kidney disease. Symptoms caused if the patient has chronic kidney failure include uremia. Uremic pruritus is an uncomfortable condition for the patient, so it requires medication or treatment to help relieve it. Pruritus that occurs in hemodialysis patients causes itching and dryness of the skin. Objectives: The purpose of this study was to determine the effect of giving oat lotion on itching sensation in hemodialysis patients who experienced pruritus at the RS UMMI Bogor in 2020. Methods: This study used
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Kumar, Ajay, Saujan Subedi, Abhisek Maskey, Mohammad Asim, Brijesh Sathian, and Deepika Neupane. "Uremic Pruritus and associated factors in Chronic Dialysis Patients: An Observational Study in Western Nepal." Birat Journal of Health Sciences 5, no. 3 (2020): 1224–30. http://dx.doi.org/10.3126/bjhs.v5i3.33703.

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Introduction: Pruritus is one of the well-recognized major skin derangements in patients with advanced renal failure and are usually without visible skin lesions. Only few studies have addressed this issue in Nepalese population.
 Objective:.The present study aims to identify the prevalence and associated factors of uremic pruritus in chronic dialysis patients in western Nepal.
 Methodology:A prospective observational study was conducted to include all chronic dialysis patients with uremic pruritus at the Manipal Teaching Hospital, Pokhara, Nepal over a period of one year (June 2018
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Nguyen, Christopher, and Monica Li. "Iron Deficiency Anemia Pruritus: A Review with Proposed Mechanisms of Action." SKIN The Journal of Cutaneous Medicine 8, no. 2 (2024): 1365–73. http://dx.doi.org/10.25251/skin.8.2.2.

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Chronic generalized pruritus without a primary skin lesion presents a dilemma for clinicians. A minority can be attributed to systemic diseases. Iron deficiency anemia (IDA) presents one such poorly defined cause. We comprehensively review the literature to support IDA pruritus as a valid etiology in the patient with chronic, generalized pruritus. Several studies and case reports describe the association of pruritus and IDA, and more importantly, resolution of the pruritus upon iron supplementation, strongly suggesting IDA as the primary etiology. Thus, we recommend obtaining a CBC and iron st
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Perwiraningtyas, Pertiwi, and Ani Sutriningsih. "HUBUNGAN LAMA TERAPI HEMODIALISA DENGAN SKALA PRURITUS PASIEN GAGAL GINJAL KRONIS." Care : Jurnal Ilmiah Ilmu Kesehatan 9, no. 2 (2021): 197–207. http://dx.doi.org/10.33366/jc.v9i2.2311.

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Patients with end-stage chronic renal failure required hemodialysis to survive for a long time. One of the complications of hemodialysis therapy is pruritus. Pruritus interfered with the patient's activities and sleep quality so that it has an impact on the quality of life. The purpose of this study was to determine the relationship between the length of hemodialysis therapy and pruritus in patients with chronic kidney failure. The research design is cross sectional. The population of all chronic kidney failure patients at Panti Waluya Hospital Malang during November 2020 who underwent hemodia
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Kaliuzhna, L. D. "CHRONIC PRURITUS IN CHILD’S SKIN DISEASES." Dermatology and Venerology, no. 3 (2020): 29–32. http://dx.doi.org/10.33743/2308-1066-2020-3-29-32.

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The article presents modern information on the clinical use and safety of the first-generation H1-antihistamine – dimetindene maleate. Pruritus (itch) mediators act both peripherally (histamine, proteases) and centrally (opioids) and has several mechanisms. Pruritus is the dominant symptom of skin diseases; almost all inflamamatory skin diseases can have associated pruritus. Doctors have focused on the almost one dermatosis with signs of itching – atopic dermatitis. At the same time, the range of diseases, both dermatological and systemic, accompanied by itching, is much wider.
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Panahi, Yunes, Amirhossein Sahebkar, Mojtaba Amiri, et al. "Improvement of sulphur mustard-induced chronic pruritus, quality of life and antioxidant status by curcumin: results of a randomised, double-blind, placebo-controlled trial." British Journal of Nutrition 108, no. 7 (2011): 1272–79. http://dx.doi.org/10.1017/s0007114511006544.

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Skin is among the first and most heavily damaged organs upon sulphur mustard (SM) exposure. Pruritus is the most common chronic skin complication of SM, which adversely affects the quality of life (QoL). However, current therapies for the management of SM-induced pruritus are very limited and associated with side effects. The present trial investigated the efficacy of curcumin in the alleviation of SM-induced chronic pruritic symptoms. A total of ninety-six male Iranian veterans (age 37–59 years) were randomised to receive either curcumin (1 g/d, n 46) or placebo (n 50) for 4 weeks. Serum conc
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Sembiring, Friska Br, Reisy Tane, and Lily Suryani. "PEMBERIAN AROMATERAPI PEPPERMINT KEPADA PASIEN HD DI RSU SEMBIRING DELI TUA." Jurnal Pengabdian Masyarakat Putri Hijau 1, no. 1 (2021): 1–5. http://dx.doi.org/10.36656/jpmph.v1i1.508.

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Uremic pruritus is one of the complaints that often occurs in patients with chronic renal failure which is an uncomfortable sensation or itching and can cause disturbances during the day or night and can even occur throughout the day such as sleep disturbances, activity, depression and skin complications that can reduce quality of life for patients with chronic renal failure. Patients undergoing hemodialysis therapy will be faced with a variety of health status disorders, one of the most common complications is uremic pruritus (UP) with a multi-factor cause. The intensity and spatial distribut
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Görg, Max, Claudia Zeidler, Manuel P. Pereira, and Sonja Ständer. "Generalized chronic pruritus with fibromyalgia." JDDG: Journal der Deutschen Dermatologischen Gesellschaft 19, no. 6 (2021): 909–11. http://dx.doi.org/10.1111/ddg.14498.

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Agarwal, Puneet, Vinita Garg, Priyanka Karagaiah, Jacek C. Szepietowski, Stephan Grabbe, and Mohamad Goldust. "Chronic Kidney Disease-Associated Pruritus." Toxins 13, no. 8 (2021): 527. http://dx.doi.org/10.3390/toxins13080527.

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Pruritus is a distressing condition associated with end-stage renal disease (ESRD), advanced chronic kidney disease (CKD), as well as maintenance dialysis and adversely affects the quality of life (QOL) of these patients. It has been reported to range from 20% to as high as 90%. The mechanism of CKD-associated pruritus (CKD-aP) has not been clearly identified, and many theories have been proposed to explain it. Many risk factors have been found to be associated with CKD-aP. The pruritus in CKD presents with diverse clinical features, and there are no set features to diagnose it.The patients wi
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Vena, Gino A., and Nicoletta Cassano. "Toxic drug-induced chronic pruritus." Immunopharmacology and Immunotoxicology 34, no. 6 (2012): 1075–76. http://dx.doi.org/10.3109/08923973.2012.690100.

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Pereira, Manuel P., and Sonja Ständer. "Measurement tools for chronic pruritus." Itch 4, no. 4 (2019): e29. http://dx.doi.org/10.1097/itx.0000000000000029.

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Bonchak, Jonathan G., and Peter A. Lio. "Nonpharmacologic interventions for chronic pruritus." Itch 5, no. 1 (2020): e31. http://dx.doi.org/10.1097/itx.0000000000000031.

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Yosipovitch, Gil. "Chronic pruritus: a paraneoplastic sign." Dermatologic Therapy 23, no. 6 (2010): 590–96. http://dx.doi.org/10.1111/j.1529-8019.2010.01366.x.

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JANCIN, BRUCE. "Aprepitant Relieves Refractory Chronic Pruritus." Skin & Allergy News 42, no. 1 (2011): 6. http://dx.doi.org/10.1016/s0037-6337(11)70008-0.

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Kandyil, Roshini, Nadia S. Satya, and Robert A. Swerlick. "Chronic pruritus associated withHelicobacter pylori." Journal of Cutaneous Medicine and Surgery: Incorporating Medical and Surgical Dermatology 6, no. 2 (2002): 103–8. http://dx.doi.org/10.1007/s10227-001-0032-y.

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Weisshaar, E., J. Szepietowski, U. Darsow, et al. "European Guideline on Chronic Pruritus." Acta Dermato Venereologica 92, no. 5 (2012): 563–81. http://dx.doi.org/10.2340/00015555-1400.

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Grundmann, Sonja, and Sonja Ständer. "Chronic Pruritus: Clinics and Treatment." Annals of Dermatology 23, no. 1 (2011): 1. http://dx.doi.org/10.5021/ad.2011.23.1.1.

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Gupta, Aditya K. "Chronic Pruritus: An Uncommon Cause." Archives of Dermatology 124, no. 7 (1988): 1105. http://dx.doi.org/10.1001/archderm.1988.01670070093030.

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Nevols, Jacqueline. "Chronic kidney disease-associated pruritus." Journal of Kidney Care 10, no. 1 (2025): 28–30. https://doi.org/10.12968/jokc.2025.10.1.28.

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Mustafa Sh. Abdulqahar and Ali A. Kasim. "Assessment of Serum Levels of Total Bile Acids in Chronic Kidney Disease Patients on Hemodialysis with and without Uremic Pruritus." Iraqi Journal of Pharmaceutical Sciences 33, (4SI) (2025): 179–86. https://doi.org/10.31351/vol33iss(4si)pp179-186.

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Chronic kidney disease patients undergoing hemodialysis are frequently suffering from uremic pruritus, which can be quite uncomfortable. Uremic pruritus affects over 40% of hemodialysis patients. Bile acids have been implicated in the pathogenesis of pruritus; especially in conditions associated with cholestasis. The purpose of the study is to investigate the serum levels of total bile acids in chronic kidney disease patients on hemodialysis, with and without uremic pruritus. Ninety adults, chronic kidney disease patients who were on chronic hemodialysis at the hemodialysis unit at Al-Fallujah
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46

Günther, Marlene, Charlotte Kobus, Caroline Perner, Aline Schönenberg, and Tino Prell. "Chronic Pruritus in Geriatric Patients: Prevalence, Associated Factors, and Itch-related Quality of Life." Acta Dermato-Venereologica 105 (April 9, 2025): adv42003. https://doi.org/10.2340/actadv.v105.42003.

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Chronic pruritus is a common condition that significantly impacts quality of life. However, data on chronic pruritus in geriatric populations remain limited. A prospective observational study was conducted at the Centre for Geriatrics in Southern Saxony-Anhalt (ZASSA), involving 201 geriatric patients (mean age 83.5±5.1 years). Chronic pruritus was found in 23.4% of patients, persisting for an average of 8 years with moderate to severe intensity (mean=6.36 on a 0 to 10 numeric scale). It commonly affected the legs (48.9%) and arms (44.7%) and was linked to depressive symptoms and daily medicat
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SAMI, M., T. TAHIR, P. MAL, AHK SHERWANI, MK LUHANO, and A. MANSOOR. "FREQUENCY OF CHRONIC KIDNEY DISEASE ASSOCIATED PRURITUS AND ITS ASSOCIATION WITH SLEEP QUALITY IN HEMODIALYSIS PATIENTS." Biological and Clinical Sciences Research Journal 2023, no. 1 (2023): 443. http://dx.doi.org/10.54112/bcsrj.v2023i1.443.

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A cross-sectional study was conducted at the Department of Medicine, Khyber Teaching Hospital Peshawar, between November 2022 and April 2023. The study aimed to evaluate the frequency of pruritus associated with chronic kidney disease (CKD) and its correlation with sleep quality in hemodialysis patients. The study cohort comprised 55 individuals diagnosed with CKD, aged between 18 and 70, and of both genders. Chi-square and Independent Samples T-tests were used for statistical analysis, and a significance level of P < 0.05 was considered statistically significant. The study found that 39 (7
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Chung, Bo Young, Ji Young Um, Jin Cheol Kim, Seok Young Kang, Chun Wook Park, and Hye One Kim. "Pathophysiology and Treatment of Pruritus in Elderly." International Journal of Molecular Sciences 22, no. 1 (2020): 174. http://dx.doi.org/10.3390/ijms22010174.

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Pruritus is a relatively common symptom that anyone can experience at any point in their life and is more common in the elderly. Pruritus in elderly can be defined as chronic pruritus in a person over 65 years old. The pathophysiology of pruritus in elderly is still unclear, and the quality of life is reduced. Generally, itch can be clinically classified into six types: Itch caused by systemic diseases, itch caused by skin diseases, neuropathic pruritus, psychogenic pruritus, pruritus with multiple factors, and from unknown causes. Senile pruritus can be defined as a chronic pruritus of unknow
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Silvestri, Silvestri, and Anggraeni Noviandini. "A Literature Review of Pruritus in Elderly." Asian Journal of Engineering, Social and Health 2, no. 10 (2023): 1086–101. http://dx.doi.org/10.46799/ajesh.v2i10.142.

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Pruritus is a relatively common symptom that anyone can experience at any point in their life and is more common in the elderly. Pruritus in elderly can be defined as chronic pruritus in a person over 65 years old. The pathophysiology of pruritus in elderly is still unclear, and the quality of life is reduced. Generally, itch can be clinically classified into six types: Itch caused by systemic diseases, itch caused by skin diseases, neuropathic pruritus, psychogenic pruritus, pruritus with multiple factors, and from unknown causes. Senile pruritus can be defined as a chronic pruritus of unknow
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Park, Soh-Yeon, and Won-Sik Shim. "Current Trends in Causes and Mechanisms of Pruritus Induced by Systemic Diseases." Yakhak Hoeji 66, no. 3 (2022): 115–24. http://dx.doi.org/10.17480/psk.2022.66.3.115.

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Pruritus is a sensation that evokes a desire to scratch the skin. In particular, pruritus can be a burden for affected people when it becomes severe and chronic, as it deteriorates the quality of life. Dermatological diseases such as atopic dermatitis are mostly recognized as major pruritus-related disorders. Surprisingly, some non-dermatological systemic diseases can also evoke pruritus. In this review, we summarized the underlying causes and mechanisms of three nondermatological pruritus-related systemic diseases: including chronic kidney disease, cholestatic liver disease, and neoplasm. In
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