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Rozprawy doktorskie na temat „Circadian”

Autor: Grafiati
Data publikacji: 4 czerwca 2021
Data aktualizacji: 25 lipca 2025

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1

Zhang, Yuan. "Circadian clocks and cancer : The implication of BMAL1 (brain and muscle Arnt-like protein-1) in colorectal and breast carcinoma development and treatment." Thesis, Université Paris-Saclay (ComUE), 2019. http://www.theses.fr/2019SACLS422.

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BMAL1, une protéine centrale de l'horloge circadienne.L’inactivation de BMAL1 (BMAL1-KO) entraîne une perte complète de la rythmicité dans les horloges central et périphérique. Le travail de ma thèse se concentre sur le rôle du gène BMAL1 dans la développement et le traitement des cancers du sein et du côlon.1. Pharmacodynamique in vitro de l’Everolimus en fonction du temps d’administration malgré une horloge circadienne défectueuse ((Zhang et al., 2018) (Zhang, Levi and Chang, 2018)L’everolimus (EV) est un inhibiteur de la mTOR chez les mammifères et il est utilisé pour traiter le cancer du s
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2

Cervela, Cardona Luis Manuel. "Functional studies on the circadian regulation of mitochondrial activity in Arabidopsis thaliana." Doctoral thesis, Universitat Autònoma de Barcelona, 2019. http://hdl.handle.net/10803/669786.

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El reloj circadiano es un mecanismo celular endógeno capaz de medir el paso del tiempo y traducir las señales medioambientales, principalmente luz y temperatura, en respuestas temporales que resultan en ritmos metabólicos y fisiológicos de aproximadamente 24 horas. Esta coordinación temporal les permite a los seres vivos predecir y anticipar cambios periódicos en el medioambiente. A pesar de su importancia para la adaptación y supervivencia de las plantas, la posible función regulatoria del reloj circadiano sobre la actividad y homeostasis mitocondrial ha sido difícil de elucidar. En est
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3

Chen, Weiwei. "Characterization of the movement of a circadian protein in the temperature-dependent root synchronization of Arabidopsis thaliana." Doctoral thesis, Universitat Autònoma de Barcelona, 2020. http://hdl.handle.net/10803/670449.

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El rellotge circadià està sincronitzat per senyals mediambientals externes, principalment la llum i la temperatura. Entendre com respon el rellotge circadià de la planta a les oscil·lacions de temperatura és crucial per comprendre la capacitat de resposta de la planta a l'entorn. En aquesta tesi doctoral, trobem una funció prevalent depenent de la temperatura de l'component de el rellotge d'Arabidopsis EARLY Flowering 4 (ELF4) en el rellotge circadià de l'arrel. En plantes en les quals l'àpex aeri s'ha eliminat, el rellotge pot funcionar en les arrels, tot i que exhibeix un període més curt i
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4

Murphy, Barbara Anne. "INVESTIGATIONS OF CIRCADIAN REGULATION AND IMMUNE-CIRCADIAN INTERACTION IN THE HORSE." UKnowledge, 2007. http://uknowledge.uky.edu/gradschool_diss/546.

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The circadian system provides animals with a means to adapt internal physiology to the constantly changing environmental stimuli that exists on a rotating planet. Light information is translated into molecular timing mechanisms within individual pacemaker cells of the mammalian hypothalamic suprachiasmatic nucleus (SCN) via transcriptionaltranslational feedback loops. Humoral and neural outputs from this master clock result in circadian rhythms of physiology and behavior. The hierarchy of the circadian system involves SCN synchronization of cellular clocks within peripheral tissues so that dif
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5

Jaeger, Cassie Danielle. "Chronic Circadian Misalignment Disrupts the Circadian Clock and Promotes Metabolic Syndrome." OpenSIUC, 2015. https://opensiuc.lib.siu.edu/dissertations/1081.

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Obesity, metabolic syndrome, and diabetes represent a major source of morbidity and mortality in the United States and worldwide. Chronic misalignment of an organism’s internal circadian clock with diurnal, cyclic changes in the external environment, prevalent in professions that require shift work, contributes significantly to Type 2 Diabetes development. Experimentally, only short-term models of circadian disruption have been explored. Therefore, the goal of this study was to establish an animal model of chronic circadian disruption, which would more closely mimic the harmful misalignment as
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6

Gegnaw, Shumet T. "The connection between circadian clock impairment and retinal disease." Electronic Thesis or Diss., Strasbourg, 2023. http://www.theses.fr/2023STRAJ120.

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Cette thèse a étudié comment une dérégulation de l'horloge circadienne, qui n'avait pas été clairement associée à une maladie rétinienne jusqu'à présent, pourrait contribuer à la dégénérescence et influencer le développement et la fonction de la rétine. L'inactivation spécifique du gène horloge Bmal1 (rod-Bmal1KO) dans la lignée de souris portant la mutation P23H de la rhodopsine aggrave les symptômes de dégénérescence rétinienne, tels que la réduction de la réponse ERG et la perte de bâtonnets, induits par la seule mutation P23H. Ces observations ont été corroborées par l'analyse RNA-Seq qui
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7

Cretenet, Gaspard. "Coordination par l'horloge circadienne de l'activation rythmique du stress du RE et de la traduction dans le foie de souris." Thesis, Montpellier 2, 2010. http://www.theses.fr/2010MON20115/document.

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En premier lieu, l'horloge circadienne des mammifères joue un rôle fondamental dans le foie en régulant le métabolisme des acides gras, du glucose et des xénobiotiques. L'altération de ce rythme a été montrée comme menant à diverses pathologies incluant le syndrome métabolique. Il est supposé que l'horloge circadienne régule principalement le métabolisme en régulant l'expression des enzymes hépatiques au niveau transcriptionnel. Nous montrons que l'horloge circadienne contrôle au ssi le métabolisme hépatique en synchronisant un rythme secondaire d'une période de 12 heures caractérisé par l'act
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8

Gon?alves, Bruno da Silva Brand?o. "Estudo da organiza??o funcional do sistema circadiano por meio de ferramentas computacionais e matem?ticas." Universidade Federal do Rio Grande do Norte, 2013. http://repositorio.ufrn.br:8080/jspui/handle/123456789/17232.

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Made available in DSpace on 2014-12-17T15:36:40Z (GMT). No. of bitstreams: 1 BrunoSBG_DISSERT.pdf: 3965357 bytes, checksum: 7e3aabdd040d50db3f4557799b032b1d (MD5) Previous issue date: 2013-04-03<br>Conselho Nacional de Desenvolvimento Cient?fico e Tecnol?gico<br>Circadian rhythms are variations in physiological processes that help living beings to adapt to environmental cycles. These rhythms are generated and are synchronized to the dark light cycle through the suprachiasmatic nucleus. The integrity of circadian rhythmicity has great implication on human health. Currently it is known that di
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9

Reilly, Thomas P. "Circadian rhythms and exercise." Thesis, Liverpool John Moores University, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.297911.

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10

Brettschneider, Christian. "The cyanobacterial circadian clock." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2011. http://dx.doi.org/10.18452/16385.

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Cyanobakterien zŠhlen zu den Šltesten Lebewesen auf der Erde. Diese Bakterien, auch Blaualgen genannt, trugen wesentlich zur Sauerstoffanreicherung der Erde bei, da sie eine ausgeprŠgte FŠhigkeit zur Photosynthese besitzen. Der produzerte Sauerstoff der Photosynthese hemmt jedoch eine weitere AktivitŠt von Cyanobakterien, die Stickstofffixierung. Um die Hemmung zu vermeiden, werden diese AktivitŠten zeitlich getrennt und optimal dem tŠglichen Hell-Dunkel-Rhythmus angepasst. Ein evolutionŠrer Vorteil wird erzielt, wenn der Organismus diesen Rhythmus antizipiert und sich darauf vorbereitet. Aus
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11

Galvanin, Silvia. "Circadian Clock Study Through Frequency-Encoded Entrainment Stimulations." Doctoral thesis, Università degli studi di Padova, 2018. http://hdl.handle.net/11577/3422301.

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Circadian clocks are intrinsic, time-tracking systems that enable organisms to maintain their physiological state and their synchrony with the 24-hour rotation of the Earth, by partitioning behavioural and metabolic processes according to time of day within each tissue. They are entrained to the external environment by light/dark cycles and by food timing, which act as clock synchronizers. Emerging evidence suggests that circadian regulation is intimately linked to metabolic homeostasis and that dysregulation of circadian rhythms can contribute to disease. Conversely, metabolic signals also fe
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12

Palacios, Jordán Héctor. "Metabolomics strategy to comprehend the interactions between circadian rhythms and flavanol activity on the hepatic metabolism." Doctoral thesis, Universitat Rovira i Virgili, 2019. http://hdl.handle.net/10803/668962.

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Un extracte de proantocianidinas extretes de la llavor del raïm (GSPE) ha estat relacionat amb un ampli rang de efectes beneficiosos per la prevenció i tractament de les alteracions metabòliques hepàtiques induïdes per l’obesitat, p.e., la resistència a la insulina o l’esteatosi. A més, el GPSE és capaç de modular els ritmes circadians del fetge, els quals es troben desajustats a l’obesitat, suggerint que el GSPE pot regular parcialment el metabolisme de lípids i glucosa modulant els ritmes circadians hepàtics. La metabolòmica per RMN pot ser una tècnica adequada per l’estudi de la interacci
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13

Silva, Patrícia Tachinardi Andrade. "To be diurnal or nocturnal: the interplay of energy balance and time of activity in subterranean rodents (Ctenomys aff. knighti) and laboratory mice (Mus musculus)." Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/41/41135/tde-25072017-110626/.

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Studies that show discrepancy between nocturnal and diurnal activity under laboratory and field conditions, respectively, have become increasingly common in rodents and suggest that the definition of temporal niche is far more plastic than originally suspected. Recently, it has been proposed that factors that challenge the animal\'s energy balance play an important role in temporal niche switches. Food availability and environmental temperatures could then be one of the fundamental differences between field and laboratory that could alter the temporal daily pattern of activity. In laboratory,
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14

Chassard, David. "Implication du système circadien dans la fonction de reproduction chez la souris femelle." Thesis, Strasbourg, 2015. http://www.theses.fr/2015STRAJ060/document.

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Les neurones à Kisspeptine (Kp) de l'AVPV sont essentiels pour la survenue du pic de LH. Celle-ci est conditionnée par les concentrations circulantes d'oestrogènes (E2) et le moment du jour. Nous avons étudié si les neurones à Kp de l'AVPV étaient le lieu d'intégration de deux messages chez des souris sauvages intactes : un message E2, et un message temporel. Nous voulions savoir si ces neurones hébergeaient une horloge secondaire impliquée dans la temporalité du pic de LH. Durant l'après-midi du proestrus, une baisse drastique de l'immunoréactivité (ir) de Kp apparaît 2h avant la survenue du
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15

Otway, Daniella Theresia. "Circadian rhythms in adipose tissue." Thesis, University of Surrey, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.511108.

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16

Vijayan, Vikram. "Circadian Gene Expression in Cyanobacteria." Thesis, Harvard University, 2012. http://dissertations.umi.com/gsas.harvard:10665.

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Cyanobacteria are photosynthetic prokaryotes that live in aquatic environments. The cyanobacterium Synechococcus elongatus PCC 7942, (hereafter S. elongatus) coordinates its day and night behaviors via a circadian clock. The clock is entrained by light/dark cycles but continues to run in constant light conditions. The core circadian clock in S. elongatus is encoded by post-translational modifications of three Kai proteins, but the extent and mechanism of circadian gene expression are unknown. We provide the first unbiased characterization of circadian gene expression in S. elongatus, demonstra
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17

Coyle, Kieran. "Circadian variation in cognitive functioning." Thesis, Cardiff University, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.293015.

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18

Smith, Karen Lynn. "Entrainment of the circadian clock." Thesis, University of Cambridge, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.624358.

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19

Topacio, Tracey Karen B. "Circadian Disruption, Diet, and Exercise." Kent State University / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=kent1382122230.

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20

Jasper, Isabelle. "Circadian rhythms in sensorimotor control." Tönning Lübeck Marburg Der Andere Verl, 2009. http://d-nb.info/997031034/04.

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21

Crosby, Priya. "Metabolic regulation of circadian timekeeping." Thesis, University of Cambridge, 2017. https://www.repository.cam.ac.uk/handle/1810/269019.

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Circadian rhythms are self-sustained endogenous biological oscillations with a period of approximately 24 hours. These rhythms are observed widely across kingdoms and at all levels of biological scale. Recent work has shown there to be circadian variation in metabolism, both at the organismal and cellular level. It has also been posited that rhythmic production of metabolites might be essential for maintenance of circadian rhythmicity within cells, even in the absence of nascent transcription. The first portion of this thesis investigates the contribution of primary carbohydrate metabolism to
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22

Busza, Ania. "Molecular and Behavioral Analysis of Drosophila Circadian Photoreception and Circadian Thermoreception: A Dissertation." eScholarship@UMMS, 2007. https://escholarship.umassmed.edu/gsbs_diss/343.

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Circadian clocks are biological timekeepers that help maintain an organism’s behavior and physiological state optimally timed to the Earth’s day/night cycle. To do this, these internal pacemakers must accurately keep track of time. Equally importantly, they must be able to adjust their oscillations in response to external time cues to remain properly synchronized with the environment, and correctly anticipate environmental changes. When the internal clock is offset from its surrounding day/night cycle, clinically relevant disruptions develop, ranging from inconveniences such as jet-lag to more
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23

Fung, Uceda Jorge Alberto. "Characterization of the circadian clock function in the control of cell cycle progression to modulate growth in Arabidopsis thaliana." Doctoral thesis, Universitat Autònoma de Barcelona, 2018. http://hdl.handle.net/10803/664286.

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La función circadiana es esencial para el crecimiento y adaptación de las plantas a su entorno. La maquinaria molecular responsable de la generación de ritmos circadianos está basada en la expresión rítmica de genes cuyo pico de expresión oscila en diferentes fases durante el día y la noche. Los ritmos de expresión génica se traducen en oscilaciones de procesos fisiológicos y de desarrollo. El crecimiento de las plantas está regulado por una plétora de procesos que en última instancia operan a través del control de la proliferación y diferenciación celular. La proliferación celular depende de
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Val, Casals Maria 1993. "Circadian regulation of macrophages in homeostasis and disease." Doctoral thesis, Universitat Pompeu Fabra, 2020. http://hdl.handle.net/10803/669532.

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Els ritmes circadians són oscil·lacions diàries en paràmetres fisiològics necessaris per a què els organismes adaptin la seva activitat als cicles de llum i foscor. A nivell molecular, la maquinària circadiana consisteix en bucles oscil·latoris de traducció-transcripció dirigides per l’activitat de les proteïnes BMAL1 i CLOCK de manera autònoma a cada cèl·lula. La maquinària circadiana regula l’activitat de diversos tipus de cèl·lules immunitàries, inclosos els macròfags. Concretament, BMAL1 pot controlar la magnitud diària de les respostes inflamatòries dels macròfags. En el present treball,
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25

Ragsdale, Raven, Colin Shone, Madeleine Miller, Andrew Shields, Thomas C. Jones, and Darrell Moore. "Circadian Resonance and Entrainment in Three Spider Species (Frontinella communis, Metazygia wittfeldae, and Cyclosa turbinata)." Digital Commons @ East Tennessee State University, 2019. https://dc.etsu.edu/asrf/2019/schedule/140.

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Circadian clocks are vital to the proper functioning of organisms’ internal processes and behavioral outputs and typically have endogenous periods that approximate (within 1-2 hours) the 24-hour solar day. Clocks that deviate significantly from about 24 hours are often associated with metabolic syndromes or other disease states. For instance, organisms with near-24-hour clocks have higher survivorship under 24-h light:dark (LD) cycles than with 22- or 26-hour cycles. Likewise, mutant organisms with 22-hour clocks survive better under 22-h cycles but fare poorly under 24- and 26-h cycles. In ot
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26

Simões, Ana Leda Bertoncini. "Estudo comparativo e variabilidade circadiana das temperaturas timpanica, oral e axilar em adultos hospitalizados." [s.n.], 2005. http://repositorio.unicamp.br/jspui/handle/REPOSIP/311342.

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Orientador: Milva Maria Figueiredo De Martino<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciencias Medicas<br>Made available in DSpace on 2018-08-04T03:29:08Z (GMT). No. of bitstreams: 1 Simoes_AnaLedaBertoncini_M.pdf: 1152293 bytes, checksum: 939294f259cff182dfd66288e6a3ac44 (MD5) Previous issue date: 2005<br>Resumo: Esta pesquisa teve como objetivo verificar a variabilidade circadiana das temperaturas timpânica, oral e axilar; correlacionar as medidas da temperatura timpânica considerando o ângulo de posicionamento e comparar as medidas entre si, em paciente
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27

Peschel, Nicolai. "New insights into circadian photoreception and the molecular regulation of the resetting of Drosophilas circadian clock." kostenfrei, 2008. http://www.opus-bayern.de/uni-regensburg/volltexte/2009/1063/.

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Martínez, Nicolás Antonio. "Interrelación entre los sincronizadores y el sistema circadiano humano= Crosstalk between synchronizers and the human circadian system." Doctoral thesis, Universidad de Murcia, 2014. http://hdl.handle.net/10803/277216.

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Establecer el patrón de temperatura de la piel de la muñeca como ritmo marcador para evaluar el sistema circadiano humano. Para ello, se plantearon los siguientes objetivos específicos: 1. Obtener el ritmo endógeno de temperatura periférica distal por medio de procedimientos matemáticos para eliminar y cuantificar los efecto enmascarantes. 2. Describir la ontogenia y el envejecimiento del patrón de temperatura periférica distal. 3. Caracterizar el régimen de exposición a la luz y su influencia sobre el sistema circadiano evaluado mediante el ritmo de temperatura en la muñeca. 4. Analizar el ef
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29

Harper, David G. "Circadian rhythm disturbances in advanced dementia /." Thesis, Connect to Dissertations & Theses @ Tufts University, 2000.

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Thesis (Ph.D.)--Tufts University, 2000.<br>Adviser: David Harder. Submitted to the Dept. of Psychology. Includes bibliographical references (leaves 90-116). Access restricted to members of the Tufts University community. Also available via the World Wide Web;
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Dowling, Glenna Annette. "Women with Parkinson's disease : circadian function /." Thesis, Connect to this title online; UW restricted, 1989. http://hdl.handle.net/1773/7326.

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Seifert, Erin. "Circadian patterns of breathing and thermoregulation." Thesis, McGill University, 2002. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=37657.

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Circadian rhythms, &sim;24-h oscillations in physiological variables, are pervasive throughout nature. Synchronization of these oscillations to the 24-h day enables organisms to take advantage of environmental cycles. In mammals, a circadian pacemaker located in the hypothalamus coordinates the overt rhythms.<br>The present study investigates aspects of the 24-h organization of breathing, and its chemical control, and of thermoregulation in mammals. Pulmonary ventilation (V&dot;E), oxygen consumption ( V&d2;O2 ), body temperature (Tb), and locomotor activity were monitored by non-invasive mean
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32

Shaw, Linda Marie. "Characterisation of ENU-induced circadian mutants." Thesis, University of Oxford, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.497452.

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Gesto, João Silveira Moledo. "Circadian clock genes and seasonal behaviour." Thesis, University of Leicester, 2011. http://hdl.handle.net/2381/10266.

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Circadian and photoperiodic phenomena serve to organize the temporal pattern of various biological processes. While the former generates endogenous daily rhythms, the latter is related to seasonality. In Drosophila melanogaster, the gene timeless (tim) encodes a cardinal component of the circadian clock and also contributes to photoperiodism, which is observed as an adult reproductive diapause. In this work, natural tim variants were examined for diapause across different temperatures and photoperiods. The newly derived allele, ls-tim, exhibited consistently higher diapause levels than the anc
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34

Valekunja, Utham Kashyap. "The mammalian circadian transcriptome and epigenome." Thesis, University of Cambridge, 2015. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.709142.

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Curran, Jack. "Ageing and the Drosophila circadian clock." Thesis, University of Bristol, 2019. http://hdl.handle.net/1983/7b02ec7c-f6a2-4640-b50f-ce97a66a5a11.

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It is well established that elderly individuals have increased difficulty sleeping at night combined with falling asleep and waking up earlier. Although these age-related declines in circadian output are clearly observable in activity recordings of laboratory animals, the underlying changes in molecular and neuronal activity remain unknown. The fruit fly, Drosophila melanogaster, has long been used as a model for studying the circadian system and for ageing research. In this thesis Drosophila was used as a model to study the effect of ageing on circadian and sleep behaviour. Circadian behaviou
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Beynon, Amy Louise. "Neuroimmune modulation of the circadian clock." Thesis, Swansea University, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.678517.

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Kushniryk, O. V. "Impact of seasons on circadian rhythm." Thesis, БДМУ, 2020. http://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/18035.

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Santos, Carlo Steven. "Circadian Control of Cell Cycle Progression." Thesis, Virginia Tech, 2009. http://hdl.handle.net/10919/76987.

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Tumorigenesis is the result of uncontrolled cell growth due to the deregulation of cell cycle checkpoints 1. Period 2 (Per2) is a tumor suppressor that oscillate in expression in a 24-hour cycle 2, 3. Here, we show that Per2 interacts with the tumor suppressor protein p53. Both G1 and G2 checkpoint pathways involve a p53 dependent pathway which can trigger the cell to go through cell arrest or programmed cell death4. Understanding all the mitigating factors involved in regulating cell cycle progression under DNA damage can offer a better idea in how cells become immortal. Initially discovere
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Wang, Louisa Mei-Chen. "Circadian Regulation of learning and memory." Diss., Restricted to subscribing institutions, 2008. http://proquest.umi.com/pqdweb?did=1695050971&sid=1&Fmt=2&clientId=1564&RQT=309&VName=PQD.

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40

Pearson, Kristen A. "Circadian rhythms, fatigue, and manpower scheduling." Thesis, Monterey, Calif. : Springfield, Va. : Naval Postgraduate School ; Available from National Technical Information Service, 2004. http://library.nps.navy.mil/uhtbin/hyperion/04Dec%5FPearson.pdf.

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41

Sra, Sana. "Circadian Variations and Risky Decision Making." Scholarship @ Claremont, 2019. https://scholarship.claremont.edu/scripps_theses/1291.

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Over the past decades, decision making under risk has garnered a great amount of attention both in the field of economics and psychology. Although state-dependent variabilities of risk taking are well-documented, little is known about the effects of a person’s preferred time of day, or chronotype, in risky decision making. Under circumstances of circadian mismatch (e.g., when an “early bird” makes decisions in the evening), research suggests that decision making may reflect a greater reliance on heuristics, such as using stereotypes in social judgments. However, the effects of circadian mismat
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MORBIATO, ELISA. "Modulation of circadian rhythms by glucocorticoids." Doctoral thesis, Università degli studi di Ferrara, 2020. http://hdl.handle.net/11392/2478787.

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Il comportamento è concepito come una relazione dipendente stimolo-risposta tra un input sensoriale e una risposta motoria. Nel passaggio da input a output, l’omeostasi interna è continuamente modellata per mantenere un equilibrio ottimale della spesa energetica. Lo scopo ultimo di mantenere l’omeostasi in relazione al mondo circostante viene raggiunto attraverso la produzione di comportamenti adattativi che permettono di incrementare la fitness alla luce della selezione naturale. L’ambiente circostante può essere sia prevedibile sia imprevedibile. La prima condizione ha portato all’evoluzion
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Southern, Megan Morgan. "Mutants in the Arabidopsis circadian clock : genetic approaches to explore circadian mechanisms in the model higher plant." Thesis, University of Warwick, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.425525.

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Gil, Rodríguez Sergio. "Functional characterization of the connection between the circadian clock and the DNA damage and repair response in Arabidopsis thaliana." Doctoral thesis, Universitat Autònoma de Barcelona, 2019. http://hdl.handle.net/10803/669601.

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En la mayoría de los organismos estudiados, el reloj circadiano mantiene ritmos en fisiología, metabolismo y desarrollo en sintonía con los cambios medioambientales que suceden durante los ciclos diurnos y nocturnos. En plantas, el reloj circadiano regula la correcta periodicidad de muchos procesos cruciales como las respuestas a un gran número de estreses abióticos y bióticos. En esta Tesis Doctoral, hemos estudiado la conexión entre el reloj circadiano y la vía de respuesta al daño y reparación del DNA (DNA Damage and Repair (DDR)) en respuesta al daño de doble cadena del DNA (double s
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Trujillo, Jennifer L. "Relationships between circadian rhythms and ethanol intake in mice." Diss., [La Jolla] : University of California, San Diego, 2009. http://wwwlib.umi.com/cr/ucsd/fullcit?p3359855.

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Thesis (Ph. D.)--University of California, San Diego, 2009.<br>Title from first page of PDF file (viewed July 23, 2009). Available via ProQuest Digital Dissertations. Vita. Includes bibliographical references (p. 127-136).
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Bailey, Michael J. "Functional genomics of the avian circadian system." Texas A&M University, 2004. http://hdl.handle.net/1969.1/3318.

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The genetic identification of molecular mechanisms responsible for circadian rhythm generation has advanced tremendously over the past 25 years. However the molecular identities of the avian clock remain largely unexplored. The present studies seek to determine candidate clock components in the avian species Gallus domesticus. Construction and examination of the transcriptional profiles of the pineal gland and retina using DNA microarray analysis provided a clear view into the avian clock mechanism. Investigation of the pineal and retina transcriptomes determined the mRNA profiles of several t
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Lamba, Pallavi. "Neuronal circuitry controlling circadian photoreception in Drosophila." eScholarship@UMMS, 2017. http://escholarship.umassmed.edu/gsbs_diss/925.

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Circadian clocks are endogenous timekeeping mechanisms, which give the sense of time-of-day to most organisms. To help the organisms to adapt to daily fluctuations in the environment, circadian clocks are reset by various environmental cues. Light is one of the cardinal environmental cues that synchronize circadian clocks. In a standard 12:12 light-dark condition, Drosophila exhibits bimodal activity pattern in the anticipation of lights-on and -off. The morning peak of activity is generated by Pigment Dispersing Factor (PDF) positive small ventro-lateral neurons (sLNvs) called the M-oscillato
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Abdou, Jeanne Anne. "Circadian rhythm disruption and post-surgical recovery." FIU Digital Commons, 1998. http://digitalcommons.fiu.edu/etd/1252.

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Circadian rhythms, patterns of each twenty-four hour period, are found in most bodily functions. The biological cycles of between 20 and 28 hours have a profound effect on an individual's mood, level of performance, and physical well being. Loss of synchrony of these biological rhythms occurs with hospitalization, surgery and anesthesia. The purpose of this comparative, correlational study was to determine the effects of circadian rhythm disruption in post-surgical recovery. Data were collected during the pre-operative and post-operative periods in the following indices: body temperature, bloo
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Walmsley, Lauren. "Sensory processing in the mouse circadian system." Thesis, University of Manchester, 2016. https://www.research.manchester.ac.uk/portal/en/theses/sensory-processing-in-the-mouse-circadian-system(bd32ea60-48a8-46d4-b5db-dd83d0326d87).html.

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In order to anticipate the predictable changes in the environment associated with the earth’s rotation, most organisms possess intrinsic biological clocks. To be useful, such clocks require a reliable signal of ‘time’ from the external world. In mammals, light provides the principle source of such information; conveyed to the suprachiasmatic nucleus circadian pacemaker (SCN) either directly from the retina or indirectly via other visual structures such as the thalamic intergeniculate leaflet (IGL). Nonetheless, while the basic pathways supplying sensory information to the clock are well unders
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Power, Andrea. "Neuronal Regulation of Circadian Rhythms in Mice." Thesis, University of Manchester, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.501978.

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