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Rozprawy doktorskie na temat „Circulating Tumour Cells; Exosomes”

Autor: Grafiati

Data publikacji: 7 czerwca 2025

Data aktualizacji: 2 sierpnia 2025

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1

MAZZITELLI, CARLOTTA. "CIrculating TUmor CELls (CTCs), circulating tumor DNA (ctDNA) and exosomes (Ex) in breast cancer patients: a prospective study." Doctoral thesis, Università degli studi di Genova, 2021. http://hdl.handle.net/11567/1044956.

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Background The translational study CITUCEL aims to correlate the presence of CTCs and ctDNA at different time points with the clinical outcome of BC patients in neo-adjuvant, adjuvant or advanced setting and to compare the mutational profiles of the primary tumor, CTCs and ctDNA in the different settings. Methods CTCs have been characterized and isolated single or in pool with the DEPArray system, after immunologic negative enrichment with antibodies coupled to magnetic beads against common leukocytes and red blood cells antigens, followed by cells labelling with specific antibody for ep

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Buscail, Etienne. "Intérêt diagnostique de la biopsie liquide dans la prise en charge de l'adénocarcinome canalaire du pancréas à un stade précoce." Thesis, Bordeaux, 2019. http://www.theses.fr/2019BORD0081.

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Introduction:Un des problèmes du cancer du Pancréas (CP) est le temps de latence entre la suspicion du CP et la mise en place des traitements. Les méthodes de biopsie liquide pourraient accélérer la mise en évidence d’éléments tumoraux et le diagnostic.Objectif :L’objectif principal de l’étude était de comparer la performance diagnostique de plusieurs techniques de biopsie liquide chez des patients atteint d’un CP résécable d’emblé. L’objectif secondaire était la corrélation avec le taux de récidive post-opératoire.Méthodes:Tout d'abord, nous avons testé 2 méthodes d'enrichissement CTC pour es

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Bollu, Bapesh Krishna. "Circulating Tumour Cells in Osteosarcoma." Thesis, The University of Sydney, 2022. https://hdl.handle.net/2123/29874.

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Introduction There is now a growing body of work being conducted in the field of liquid biopsies. A liquid biopsy is a technique to look for biomarkers, arising from cancer, within the blood stream which are accessed in a non-invasive manner. These may include circulating tumour cells (CTCs), circulating tumour DNA, circulating RNA or exosomes. Osteosarcoma is the most common bony malignancy of the paediatric population. Metastatic disease has a poor prognosis with a 20-30% survival. The number of tumour cells present at distant sites when identified by traditional radiological and clini

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Khan, M. S. "Circulating tumour cells and biomarkers in neuroendocrine tumours." Thesis, University College London (University of London), 2013. http://discovery.ucl.ac.uk/1380186/.

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Neuroendocrine tumours(NETs) are heterogeneous with respect to biological behavior. Consequently, prognosis is variable and biomarkers predicting survival or tumour progression are required to inform clinical management. The best available biomarker, histological grade, is assigned using Ki-67 or mitotic count. Agreement between these two indices is implied but analysis of 131 pancreatic and 136 midgut NETs suggested discordances of 44% and 38% respectively. Ki-67 was the superior prognostic marker, making the additional value of mitotic count questionable. Detection of Circulating Tumour Cell

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Kulasinghe, Arutha Jeevana. "Circulating tumour cells in head and neck cancers." Thesis, Queensland University of Technology, 2017. https://eprints.qut.edu.au/110534/1/Arutha%20Jeevana_Kulasinghe_Thesis.pdf.

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Metastasis in head and neck cancer patients is responsible for over 50% of deaths. There are currently no tools to identify patients at risk of developing metastasis. Circulating tumour cells (CTC) represent a transient cancer cell population in the blood. In this study, the researcher has developed CTC isolation methodologies and used novel culture formulations to expand patient derived CTCs for therapy testing. Furthermore, the researcher identified biomarkers present on CTCs which could select patients for immunotherapies, a current unmet need. This work sets the foundation for a personaliz

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Nageswaran, Haritharan. "Capture of colorectal circulating tumour cells for mutational analysis." Thesis, University of Surrey, 2016. http://epubs.surrey.ac.uk/810722/.

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Colorectal cancer accounts for 13% of all cancers in the UK. Surgical resection offers the best prospects of a cure but 45% of these patients will still develop metastases with haematogenous spread suspected to be the main method of dissemination to distant sites. Circulating tumour cells (CTCs) are intermediaries in this process and whilst their exact role remains unclear, their presence has proven to be an independent prognostic factor in breast, prostate and colorectal cancer. The capture and isolation of intact CTCs for mutational analysis could not only shed light on the process of metast

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Kapeleris, Joanna C. "Circulating tumour cells in non-small cell lung cancer." Thesis, Queensland University of Technology, 2022. https://eprints.qut.edu.au/228607/1/Joanna_Kapeleris_Thesis.pdf.

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Circulating tumour cells (CTCs) have the potential to transform the management of patients with non-small cell lung cancer (NSCLC). The applications of CTCs can identify clinically actionable targets to predict treatment response and to better understand metastasis. CTCs isolated using microfluidics can be used as prognostic indicators of NSCLC as well as characterizing for markers of immunotherapy (PD-L1), molecular targets (ALK, EGFR). Short term cultures were successfully expanded in 9/70 NSCLC patients and cultured for up to 3 months. Optimization of this novel CTC culture model provides o

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Acheampong, Emmanuel. "Assessment of circulating tumour cells in lung cancer patients." Thesis, Edith Cowan University, Research Online, Perth, Western Australia, 2022. https://ro.ecu.edu.au/theses/2554.

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Lung cancer is among the most prevalent forms of cancer and remains the leading cause of cancer-associated deaths globally. Traditionally, lung cancers are classified as either non-small cell lung cancer (NSCLC) (85%) or small cell lung cancer (SCLC) (15%). About 60% of all cases are diagnosed at an advanced stage, at which the 5-year survival is only 4%. Anti-programmed cell death-1 and its ligand 1 (anti-PD-1/PD-L1) therapies have significantly improved the outcomes for lung cancer patients in recent years. However, prognosis and understanding of an individual patient’s lung cancer are often

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Hamid, Faysal-Bin. "Genetic profiling of circulating tumour cells and DNAs in patients with colorectal carcinoma." Thesis, Griffith University, 2021. http://hdl.handle.net/10072/404861.

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Over the decades, it has been considered that blood-based biopsy or liquid biopsy could be an alternative approach of tumour biopsy. To date, blood-based biomarkers such as circulating tumour cell (CTC) and circulating tumour DNA (ctDNA) have been widely studied and found their significance in patients with several carcinomas including colorectal carcinoma (CRC). Biologically, both CTC and cell-free DNA (cfDNA) have been released from the tumour and circulate freely in the blood. Although they are present in trivial quantity due to minute scale of discharge and rapid clearance from the blood,

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Payne, Rachel. "The clinical and prognostic use of circulating tumour cells in breast cancer." Thesis, Imperial College London, 2011. http://hdl.handle.net/10044/1/6957.

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Adjuvant therapies such as endocrine or cytotoxic chemotherapy have been demonstrated to improve overall survival in early breast cancer patients. A blood test to monitor patients at risk of relapse is needed to identify those patients who would benefit from these treatments and those for whom it is not necessary. This is in favour of detecting disseminated tumour cells (DTCs) from painful bone marrow aspirates, currently the gold‐standard method for detecting minimal residual disease (MRD). The use of circulating tumour cells (CTCs) enriched from the blood was investigated for this purpose al

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Kimura, Kimitoshi. "Circulating exosomes suppress the induction of regulatory T cells via let-7i in multiple sclerosis." Kyoto University, 2018. http://hdl.handle.net/2433/232138.

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Lemech, C. R. "Biomarker development in endometrial cancer : circulating tumour cells, tissue methylation and genotyping studies." Thesis, University College London (University of London), 2015. http://discovery.ucl.ac.uk/1464123/.

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Endometrial cancer (EC) is the most common gynaecological malignancy in the developed world and 4th most common women’s cancer in the UK. Although approximately 75% of women present with surgically resectable disease, 20% of these will relapse and 25% of initial diagnoses occur with metastatic disease. There are currently no validated biomarkers to assess treatment response or target molecular therapies, despite evidence for targetable aberrations in the literature. The PI3K pathway in particular is commonly mutated in EC and stathmin is a recently identified phosphoprotein associated with PI3

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Marsavela, Anda-Gabriela. "Optimisation of the isolation and identification of circulating melanoma cells." Thesis, Edith Cowan University, Research Online, Perth, Western Australia, 2017. https://ro.ecu.edu.au/theses/1993.

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Although melanoma is largely curable when detected in its earliest stages, it can metastasise to other tissues, drastically reducing survival rates. The most recent therapies used to treat metastatic melanoma are effective long-term in only 11 to 33% of patients. Our ability to monitor treatment failure is limited. New prognostic markers are urgently required to allow monitoring of treatment response and disease progression. Circulating tumour cells (CTCs) are released into the bloodstream by the tumours within a patient, this being a key step in melanoma spread. Since CTCs can be detected in

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Balathasan, Lukxmi. "Characterising the role of circulating immune cells in brain metastasis." Thesis, University of Oxford, 2012. http://ora.ox.ac.uk/objects/uuid:e7620d30-7e4a-468b-b819-db4cf27eaef6.

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Brain metastasis is a frequent occurrence in cancer patients and carries a high mortality rate. The incidence of brain metastasis is on the rise, highlighting the need for improved therapeutic intervention. Immune cells have been shown to promote disseminated tumour cells to colonise the lung and liver. Therefore, we aim to determine whether immune cells also facilitate brain metastasis by describing the host immune response to tumour cells attached to the brain vasculature. We developed a model of brain metastasis by using ultrasound guidance to perform intracardiac injection of tumour cells.

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Nannmark, Ulf. "Tumour cell rheology experimental studies in vivo and in vitro on factors influencing tumor cell lodgement and survival in microvessels /." Göteborg : Dept. of Anatomy, University of Göteborg, 1992. http://books.google.com/books?id=9PhpAAAAMAAJ.

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Tay, Andee. "Circulating tumour cells and EpCAM as tools for diagnostic and mechanistic studies of lung cancer." Thesis, Imperial College London, 2015. http://hdl.handle.net/10044/1/25756.

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Increasingly, lung cancer treatment depends on the molecular characteristics of the lung tumour and studying the mechanisms of potential lung cancer molecular markers is important in order to identify new, targeted treatment options. The cell surface protein, EpCAM is one potential therapeutic target. Traditionally considered an adhesion protein, recent studies in breast and colon cancer have shown that EpCAM also undergoes proteolytic cleavage. Its c-terminal tail is released, acting as nuclear signalling factor that may contribute to cancer progression. Lung Cancer is the leading cause of gl

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Kaplinsky, Joseph John. "Single cell analysis and cell sorting using microfluidic devices with application to circulating tumour cells." Thesis, Imperial College London, 2012. http://hdl.handle.net/10044/1/9474.

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This thesis describes the development of integrated microfluidic technology for single cell proteomic analysis, focusing on circulating tumour cells (CTCs). While single cell proteomic analysis has wide applicability across biology and medicine, CTCs form an ideal first application. Circulating tumour cells are intimately involved in metastasis, the step in cancer overwhelmingly responsible for death, yet have proved hard to study. Single cell microfluidic technology is ideal first because the quantity of material available is inherently at the level of a few cells and second because cell to c

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Hassan, Sara. "Epithelial-mesenchymal plasticity in circulating tumour cells from patients with metastatic cancers and PDX models." Thesis, Queensland University of Technology, 2022. https://eprints.qut.edu.au/228621/8/Sara_Hassan_Thesis.pdf.

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There is growing concern about the relevance of epithelial mesenchymal plasticity (EMP) status of primary tumours in influencing their metastatic potential. Circulating tumour cells (CTCs) provide a window into the metastatic process, and molecular characterisation of CTCs could lead to better understanding of the mechanisms involved in the metastatic cascade. This thesis is an investigation of molecular characteristics of EMP in tumours and CTCs using patient-derived xenograft models and patient blood samples. The CTC heterogeneity observed emphasises the complexity in CTC isolation and class

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Theocharous, Panteli. "Novel approaches in the detection and characterisation of circulating and micrometastatic tumour cells in epithelial malignancies." Thesis, University College London (University of London), 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.248387.

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Beasley, Aaron. "Genetic markers in circulating tumour cells as a measure of the metastatic propensity of uveal melanoma." Thesis, Edith Cowan University, Research Online, Perth, Western Australia, 2017. https://ro.ecu.edu.au/theses/1968.

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Background: Uveal melanoma (UM) is an extremely aggressive disease with approximately 50% of patients developing incurable metastatic disease. Therefore, accurate prognosis of a patient is necessary for closer follow up and the earlier implementation of systemic adjuvant therapies in those most likely to develop metastatic disease. Fortunately, UM can be classified into two distinct molecular classes based on clinically validated gene expression profiling, chromosomal aberrations and specific driver mutations, which accurately predict the metastatic propensity of the primary tumour. However, g

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Asante, Du-Bois. "Development and evaluation of methodologies for analysis of CTC and ctDNA in patients with ovarian carcinoma." Thesis, Edith Cowan University, Research Online, Perth, Western Australia, 2022. https://ro.ecu.edu.au/theses/2570.

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About 70% of patients with ovarian cancer (OC) are diagnosed at an advanced stage (III-IV), with associated poor prognosis, even after chemotherapeutic interventions (mostly platinum taxane-based), leading to poor survival rates. The current biomarkers available in the clinic are not enough for efficient prognostication and surveillance of OC. Hence, more accurate and reliable biomarkers of patient disease status are urgently required. Currently, histopathological evaluation of tumour biopsies is the gold standard in clinical practice with the purpose of evaluating specific biomarkers to predi

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Spåre, Emil. "Affinity Based Capture of Circulating Tumour Cells Using Designed Ankyrin Repeat Proteins (DARPins) in a Microfluidic System." Thesis, KTH, Proteinvetenskap, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-299888.

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Designade ankyrinupprepningsproteiner (DARPiner) är små, mycket stabila antikroppsmimetiska proteiner. I det här projektet användes anti-EpCAM-DARPiner tillsammans med mikrofluidik för att avgära om de kunde fånga upp HCT116-celler mer effektivt än anti-EpCAM-antikroppar. Ytorna på insidan av mikroffluidikkanaler förändrades genom bindning av N-γ-maleimidobutyryl-oxysuccinimidester (GMBS) och merkaptopropyltrietoxysilan (MPTES) för anti-EpCAM-antikroppar och GMBS och (3-aminopropyl)trietoxysilan (APTES) för DARPiner. Båda kanaltyperna testades genom inflöde av cancerceller och helblod blandat

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Ahmad-Cognart, Hamizah. "Study of the Metastatic Process of Circulating Tumour Cells by Organ-on-a-Chip In Vitro Models." Thesis, Sorbonne Paris Cité, 2018. http://www.theses.fr/2018USPCC139/document.

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90% de la mortalité par cancer provient de tumeurs disséminées, ou métastases. Ces métastases se forment à partir de cellules tumorales qui s'échappent d'une tumeur primaire, circulent dans le sang, puis quittent les vaisseaux sanguins pour enfin aller nicher dans des organes distants et former des tumeurs secondaires. Les processus par lesquels ces cellules circulantes envahissent les organes distants, remodèlent leur environnement pour créer une «niche micrométastatique», prolifèrent pour produire des métastases macroscopiques, sont mal connus, principalement en raison d'un manque de modèles

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Saggese, Matilde. "A novel method to quantify gamma H2AX foci in circulating tumour cells in patients receiving chemotherapy for colorectal cancer." Thesis, University College London (University of London), 2018. http://discovery.ucl.ac.uk/10049500/.

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Colorectal cancer (CRC) is the third most common cancer in males and females. Circulating tumour cells (CTCs) are epithelial cancer cells that mediate haematogenous metastases and can be used as predictive and prognostic markers. Gamma-H2AX (γ- H2AX) foci represent double strand DNA breaks and DNA damage. Assessing γ-H2AX foci in CTCs could be utilised as a biomarker to measure patient response to DNAinteractive anti-cancer treatments in real time, aiding treatment decisions. The aim of this study was to develop a method to quantify changes in γ-H2AX in CTCs from metastatic CRC patients underg

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Qin, Yubo. "Developing a Poly(Dimethylsiloxane) (PDMS)/SU-8 (Negative Photoresist) Hybrid Microfluidic System for Sensitive Detection of Circulating Tumour Cells." Thesis, Université d'Ottawa / University of Ottawa, 2018. http://hdl.handle.net/10393/37892.

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Cancer is the second leading cause of death in the world. It is therefore critically important to detect cancer in its early stage to significantly increase the survival rate of cancer patients. Circulating tumour cells (CTCs) are cancer cells that peel off from primary tumour and enter bloodstream in early stage of a cancer, and thus it has been established that these CTCs are reliable targets for early cancer diagnosis. However, background signal reduction and optimization of CTC capturing mechanisms are still significant challenges in CTC detections with high sensitivities and accuracies. T

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Khattak, Muhammad Adnan. "Blood based biomarkers of response to immunotherapy in advanced melanoma." Thesis, Edith Cowan University, Research Online, Perth, Western Australia, 2023. https://ro.ecu.edu.au/theses/2652.

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Advanced melanoma is an aggressive cancer with a poor prognosis once disseminated to other organs. However, survival outcomes have improved recently with the introduction of new immune modulating agents, more commonly known as immune checkpoint inhibitors (ICI), with some patients deriving durable long-term benefit. The latest data indicate that the 5-year overall survival for advanced melanoma patients is now approaching 50%. These agents are very expensive and can lead to substantial toxicity that can place a huge economic burden on the health system. Moreover, different combinations of thes

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Chudasama, Dimple. "Discovery and development of liquid biomarkers for ovarian and lung cancer." Thesis, Brunel University, 2018. http://bura.brunel.ac.uk/handle/2438/16174.

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Survival rates in cancers have improved vastly over the years. However, some survival rates remain extremely low, as is the case for ovarian and lung cancer. The lack of robust and reliable biomarkers is strongly reflected in the absence of pre-screening programs, and as such, most patients in these cancer types are diagnosed only in advanced stages, leaving few treatment options. Moreover, relapse and resistance to therapies adds to the complexities of treating these diseases, even in the era of targeted drug development. Research has shown the presence of cancer material, in the form of circ

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Jain, Jayati. "Engineering antibodies to study and improve immunomagnetic isolation of tumour cells." Thesis, University of Oxford, 2013. http://ora.ox.ac.uk/objects/uuid:81355801-b331-4705-bfef-204a29ee0347.

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Cell separation based on antibody-targeted magnetic beads has been widely used in a number of applications in immunology, microbiology, oncology and more recently, in the isolation of circulating tumour cells (CTCs) in cancer patients. Although other cell separation techniques such as size based cell filtration and Fluorescence Activated Cell Sorting have also been in popular use, immunomagnetic cell isolation possesses the advantages of high throughput, good specificity and reduced cell stress. However, certain fundamental features of the cell-bead interface are still unknown. In this study,

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Lampignano, Rita [Verfasser], Hans [Akademischer Betreuer] Neubauer, and Vlada B. [Gutachter] Urlacher. "Enrichment, isolation and molecular characterization of circulating tumour cells for treatment optimization in metastatic breast cancer / Rita Lampignano ; Gutachter: Vlada B. Urlacher ; Betreuer: Hans Neubauer." Düsseldorf : Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf, 2018. http://d-nb.info/1159767076/34.

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Milbank, Edward. "Extracellular vesicles as a therapeutic strategy to prevent or reverse obesity and its metabolic complications in the field of nanomedicine Extracellular vesicles: Pharmacological modulators of the peripheral and central signals governing obesity Microparticles from apoptotic RAW 264.7 macrophage cells carry tumour necrosis factor-a functionally active on cardiomyocytes from adult mice." Thesis, Angers, 2016. http://www.theses.fr/2016ANGE0074.

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A ce jour, les thérapies anti-obésité restent limitées. De récente études ont fourni des résultats prometteurs en démontrant une diminution du poids de la souris via une injection stéréotaxique d’une forme dominante négative de l’AMPK (AMPK DN) directement dans le noyau ventromédial hypothalamique (VMH). Cependant, le potentiel thérapeutique de cette thérapie génique se voit entravé par une libération non spécifique de l’AMPK suite à une injection intraveineuse, plus adaptée à une approche clinique. Nous avons donc développé une approche de « nanobiomédecine » en utilisant des exosomes - nanov

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Rhee, Handoo V. "Androgen deprivation therapy (ADT), metabolic syndrome and metastatic prostate cancer: In vivo and in vitro assessments of effects of metformin." Thesis, Queensland University of Technology, 2018. https://eprints.qut.edu.au/118290/2/Handoo%20Rhee%20Thesis.pdf.

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This thesis describes a translational research approach to identifying a cancer mechanism driven by metabolic syndrome. It examines the impact of androgen deprivation therapy, its association with metabolic syndrome and prostate cancer progression, and the therapeutic and metabolic benefits of adjuvant metformin. The study investigates with a randomized placebo controlled clinical trial, with characterization of the molecular mechanism of metformin in vitro using conditions to mimic physiological hormonal milieu.

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Vilsmaier, Theresa [Verfasser], and Udo [Akademischer Betreuer] Jeschke. "Influence of circulating tumour cells on the immune response of T-Lymphocytes and Angiogenic cytokines in sera of patients with the primary diagnosis of breast cancer before treatment / Theresa Vilsmaier ; Betreuer: Udo Jeschke." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2019. http://d-nb.info/1192215427/34.

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Akpe, Victor. "Breast Cancer Cell Detection and Profiling Using Nanomaterial-Derived Scaffolds." Thesis, Griffith University, 2021. http://hdl.handle.net/10072/407561.

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Background: The concentration of circulating tumour cells (CTCs) or cancer cell per mL in clinical blood sample is estimated to contain 106 white blood cells and 109 red bloods, suggesting CTCs are very rare. Other characteristics of cancer cells such as vulnerability in vitro, their minuscule sizes and variability (4-10 μm) in cluster, and the cancer cell subtypes and phenotypes etc. have been areas of intense research. Technological innovations have therefore focused on platforms for cancer cell detection, selective cancer cell capture, cancer cell separation/analysis platforms etc. Addition

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Martel, Arnaud. "Impact de la biopsie liquide dans le mélanome uvéal primitif et métastatique." Electronic Thesis or Diss., Université Côte d'Azur, 2023. http://www.theses.fr/2023COAZ6050.

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Le mélanome uvéal (MU) est le cancer intraoculaire primitif le plus fréquent chez l'adulte. Malgré une prise en charge médico-chirurgicale adaptée permettant un contrôle local de la tumeur dans plus de 90% des cas, on estime qu'environ 50% des patients présenteront des métastases, principalement hépatiques, dans les 10 années suivant le diagnostic. La dissémination métastatique du MU s'effectue uniquement par voie hématogène. Détecter le plus précocement possible la présence de cellules tumorales dans le sang circulant permettrait une prise en charge très précoce des patients, avant la survenu

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Bertazza, Loris. "Analisi delle Cellule Tumorali Circolanti nel carcinoma gastrico e nelle metastasi epatiche da cancro del colon-retto: ruolo di Survivin e CD133 come fattori prognostici." Doctoral thesis, Università degli studi di Padova, 2011. http://hdl.handle.net/11577/3427460.

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Background At present the only prognostic system routinely employed for the management of gastric cancer patients is the TNM staging classification, that identifies broad risk categories with a significant prognostic variability within each stage, which makes TNM a suboptimal predictive tool on the single patient basis. Only 10-20% of patients with liver metastases from colorectal cancer is resectable with radical intent and 60-70% will develop a relapse despite apparently curative surgery. Both these classes of patients therefore would benefit from additional treatments after surgery suc

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Lynch, David. "The isolation and identification of circulating tumour cells and circulating tumour DNA in glioblastoma patients." Thesis, 2019. http://hdl.handle.net/1959.7/uws:55969.

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Liquid biopsies are emerging as an important scientific development in cancer medicine to provide prognostic information and to help guide patient treatment and management. ‘Liquid biopsies’ is a more comprehensive term that refers to any liquid samples from patients (blood, cerebrospinal fluid, and urine predominantly), due to the vast quantity of biologic information that can be gleaned from them. They are an attractive source for biopsies because they can be easily repeated for individual patients to track disease progress, are reproducible, and can provide biological information or even di

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Morgan, Richard, and Mohamed El-Tanani. "HOX genes as potential markers of circulating tumour cells." 2015. http://hdl.handle.net/10454/9895.

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Yes<br>Circulating tumour cells (CTCs) have significant diagnostic potential as they can reflect both the presence and recurrence of a wide range of cancers. However, this potential continues to be limited by the lack of robust and accessible isolation technologies. An alternative to isolation might be their direct detection amongst other peripheral blood cells, although this would require markers that allow them to be distinguished from an exceptionally high background signal. This review assesses the potential role of HOX genes, a family of homeodomain containing transcription factors with k

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Ladeiras, Vera Maria Fernandes Bugalho. "Análises sanguíneas na detecção de cancro." Master's thesis, 2019. http://hdl.handle.net/10437/10128.

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Orientação: Marisa Nicolai<br>O cancro representa uma das principais ameaças para a nossa sociedade, tanto a nível económico, como em qualidade de vida. O diagnóstico precoce pode aumentar a probabilidade de cura e melhorar as condições de sobrevida. A detecção de cancro no sangue pode ser realizada através de biomarcadores tumorais. Hoje em dia, os principais marcadores utilizados ainda não apresentam a especificidade e a sensibilidade pretendidas. São raras as excepções em que são utilizados na practica oncológica. As biópsias líquidas vieram trazer um novo conceito para a área de oncologi

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Karlsson, Caroline. "Validation of a New Technology for Isolation of Circulating Tumour Cells." Thesis, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-261644.

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Ferreira, Dylan Gomes. "Improvement of metastic gastric cancer management glyco- exploring circulating tumour cells." Master's thesis, 2019. https://hdl.handle.net/10216/124721.

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Silva, Maria Gabriela Ferreira da. "Characterization of circulating tumour cells (CTCs) isolated on a microfluidic chip." Master's thesis, 2020. https://hdl.handle.net/10216/129980.

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Silva, Maria Gabriela Ferreira da. "Characterization of circulating tumour cells (CTCs) isolated on a microfluidic chip." Dissertação, 2020. https://hdl.handle.net/10216/129980.

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Ferreira, Dylan Gomes. "Improvement of metastic gastric cancer management glyco- exploring circulating tumour cells." Dissertação, 2019. https://hdl.handle.net/10216/124721.

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Hsieh, Chia Hsun, and 謝佳訓. "A Study of Circulating Tumour Cells Identification, Isolation and Cultivation with Clinical Relevance." Thesis, 2017. http://ndltd.ncl.edu.tw/handle/j7vtf7.

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Po, Joseph W. "Beyond epithelial circulating tumour cells (CTCs) : establishing important methods for CTC isolation and analysis." Thesis, 2019. http://hdl.handle.net/1959.7/uws:56104.

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This thesis has demonstrated the various applications for antibody-based CTC capture, extending beyond conventional methods. We reported the inclusion of EMT-markers for detection and characterisation of EMT-CTCs in the ovarian cancer setting. This methodological advancement may prove a critical step in understanding the role EMT plays in CTC formation, metastasis and potentially therapeutic resistance. In addition, we explored integration of electron microscopy methods into CTC sample processing, allowing for ultrastructure analysis of CTCs and improving the tools to help understand CTC biolo

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Wark, Landon, and Landon Wark. "Three dimensional telomeric profiles in circulating tumour cells as a method of monitoring treatment response in high-risk prostate cancer patients." 2016. http://hdl.handle.net/1993/31793.

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Prostate cancer is the second most commonly diagnosed cancer in men worldwide. Because prognosis can vary depending on tumour stage, precise diagnosis is vital. Circulating tumour cells (CTC) detach from primary and secondary tumour sites into the bloodstream. Changes in three-dimensional (3D) nuclear organization are associated with different types of cancer and were examined in this study in CTCs of high-risk prostate cancer patients. CTCs were isolated from 3mL of patient blood samples of 20 high-risk prostate cancer patients before treatment; after neoadjuvant androgen deprivation ther

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Mendes, Raquel Rodrigues. "Clinical applications of circulating tumour cells in breast cancer patients : based on a case report." Master's thesis, 2019. http://hdl.handle.net/10451/43580.

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Trabalho Final do Curso de Mestrado Integrado em Medicina, Faculdade de Medicina, Universidade de Lisboa, 2019<br>Mundialmente, o cancro da mama (CM) é considerado o cancro mais diagnosticado e mortal, sendo a maioria desta mortalidade resultado de doença metastática. Para combater este problema global, é essencial reforçar os programas de prevenção, diagnóstico e tratamento. As células tumorais circulantes (CTC) têm sido propostas como uma possível abordagem para retratar a heterogeneidade e dinâmica do CM, contribuindo para uma gestão do doente mais personalizada e holística. As CTC são célu

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Fernandes, Mariana Regueiras Teixeira Pinto. "A Microfluidic Chip for Size-Based Isolation, Detection and Characterization of Circulating Tumour Cells in Lung Cancer." Master's thesis, 2021. https://hdl.handle.net/10216/135578.

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Fernandes, Mariana Regueiras Teixeira Pinto. "A Microfluidic Chip for Size-Based Isolation, Detection and Characterization of Circulating Tumour Cells in Lung Cancer." Dissertação, 2021. https://hdl.handle.net/10216/135578.

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Carneiro, Adriana Filipa Ribeiro. "Circulating Tumour Cells: Paving the Way Towards the Identification of Epithelial and Mesenchymal Phenotypes in the Clinic." Master's thesis, 2020. http://hdl.handle.net/10316/92925.

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Dissertação de Mestrado em Biotecnologia Farmacêutica apresentada à Faculdade de Farmácia<br>O cancro colorretal (CCR) é o terceiro cancro mais incidente e o segundo com maior taxa de mortalidade a nível mundial. A principal causa de morte nestes doentes continua a ser a metastização, cerca de 60% dos mesmos são diagnosticados numa fase mais avançada da doença (fase III e IV). Há, por essa razão, uma necessidade urgente no desenvolvimento de estratégias que permitam o diagnóstico precoce e monitorização da doença metastática em CCR. Nesta perspetiva, as células tumorais circulantes (CTCs), lib

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