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1

Scott, Alexander. "Tendon overuse pathology : clinical and laboratory studies." Thesis, University of British Columbia, 2008. http://hdl.handle.net/2429/5621.

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Background: Painful tendon overuse pathology (tendinosis) is poorly understood. The objectives were to identify major cell populations within clinical tendinosis lesions, and to examine factors involved in the regulation of tendon cell death, survival, or proliferation. The overarching hypothesis was that both cell death and cell proliferation play roles in the development of tendinosis. Methods: 1: Chronic patellar tendinosis tissue was compared with normal, pain-free patellar tendon using Western blot, immunohistochemistry and in situ hybridization. A variety of cell types were examined in r
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Patel, Soyab Ahmed. "Chemical imaging for clinical pathology and bioanalysis." Thesis, University of Manchester, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.488821.

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McNicol, A. M. "Pathology of pituitary corticotrophs : Clinical and experimental studies." Thesis, University of Glasgow, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.372421.

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MUZIO, DIANE. "Clinical Supervision of Externs in Speech-Language Pathology." OpenSIUC, 2017. https://opensiuc.lib.siu.edu/dissertations/1467.

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The focus of this qualitative study was to investigate clinical supervisors’ perceptions about the externship experience in speech-language pathology. This study was designed to investigate the range of supervisors’ preparedness to mentor the extern student, self-perceptions of the role of the externship supervisor, and opinions regarding a possible professional credential. Data was collected from a focus group and individual interviews. All participants were SLPs who supervised a minimum of two graduate student externs from the same large Midwestern university. The results indicated that exte
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Akin, Faith W. "Best Practice: Clinical Vestibular Assessment." Digital Commons @ East Tennessee State University, 2011. https://dc.etsu.edu/etsu-works/2441.

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Baguley, David M., and Marc A. Fagelson. "Tinnitus: Clinical and Research Perspectives." Digital Commons @ East Tennessee State University, 2015. https://www.amzn.com/1597567213.

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Book Summary: Tinnitus: Clinical and Research Perspectives summarizes contemporary findings from basic and clinical research regarding tinnitus mechanisms, effects, and interventions. The text features a collection of international authors, active researchers, and clinicians who provide an expansive scope of material that ensures relevance for patients and professionals. Reviews and reports of contemporary research findings underscore the text s value for classroom use in audiology and otolaryngology programs. Patients and students of audiology will benefit from the text s coverage of tinnitus
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7

Thornhill, Jaime. "Emotional intelligence : aetiological role in sub-clinical eating pathology /." [St. Lucia, Qld.], 2005. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe18667.pdf.

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8

Maddison, John. "Digital image processing for prognostic and diagnostic clinical pathology." Thesis, University of Huddersfield, 2005. http://eprints.hud.ac.uk/id/eprint/22322/.

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When digital imaging and image processing methods are applied to clinical diagnostic and prognostic needs, the methods can be seen to increase human understanding and provide objective measurements. Most current clinical applications are limited to providing subjective information to healthcare professionals rather than providing objective measures. This Thesis provides detail of methods and systems that have been developed both for objective and subjective microscopy applications. A system framework is presented that provides a base for the development of microscopy imaging systems. This prac
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9

Sheepway, Lyndal. "Influences on Competency Development in Speech Pathology Students." Thesis, The University of Sydney, 2014. http://hdl.handle.net/2123/11449.

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Due to shortages of clinical education experiences for allied health students, there is a risk that curriculum decisions are made based on availability of experiences rather than evidence regarding competency development. This research was situated in the speech pathology profession in Australia. The aims were to establish current clinical education practices internationally and the drivers behind these practices, explore growth of competency in a cohort of students, and compare impacts of features of clinical placements on students’ competency growth. This was achieved through three related s
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10

Flygt, Johanna. "Oligodendrocyte pathology following Traumatic Brain Injury : Experimental and clinical studies." Doctoral thesis, Uppsala universitet, Institutionen för neurovetenskap, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-316401.

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Traumatic brain injury (TBI) caused by traffic and fall accidents, sports-related injuries and violence commonly results in life-changing disabilities. Cognitive impairments following TBI may be due to disruption of axons, stretched by the acceleration/deceleration forces of the initial impact, and their surrounding myelin in neuronal networks. The primary injury, which also results in death to neuronal and glial cells, is followed by a cascade of secondary injury mechanisms including a complex inflammatory response that will exacerbate the white matter injury. Axons are supported and protecte
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11

Bosman, Michelle. "Assessment of the effectiveness of electronic gatekeeping as a utilization management tool at Groote Schuur Hospital." Master's thesis, Faculty of Health Sciences, 2018. http://hdl.handle.net/11427/30151.

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BACKGROUND: Utilization management ensures the appropriateness of laboratory testing by reducing the performance of tests which can be reasonably avoided with no adverse effects for the patient. Electronic gatekeeping, a utilization management tool, was introduced at Groote Schuur in 2010. Criteria were based on the minimum retesting interval, healthcare location, level of experience and discipline of the requesting clinician and specific ICD-10 codes. METHODS: A retrospective observational study assessing the effectiveness of electronic gatekeeping at Groote Schuur Hospital (Cape Town, Sout
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12

Swanepoel, Hendré. "Utility of chloride and adenosine deaminase measurement in cerebrosphinal fluid for the early presumptive diagnosis of tuberculous meningitis." Master's thesis, University of Cape Town, 2017. http://hdl.handle.net/11427/25438.

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Background: Chloride and adenosine deaminase measurements in cerebrospinal fluid are still sporadically requested as part of tuberculous meningitis work-up. In the literature, evidence is contradictory and opinion is divided on their utility in clinical practice. The accuracy of both for the early presumptive diagnosis of tuberculous meningitis was investigated in patients in a region with high prevalence of tuberculosis and HIV infection in order to inform a decision on whether to continue offering these tests to clinicians. Methods: A retrospective descriptive study of diagnostic accuracy wa
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Haumann, Carel Eduard. "Investigation of an atypical protoporphyric family in South Africa." Master's thesis, University of Cape Town, 2010. http://hdl.handle.net/11427/11184.

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Includes bibliographical references (leaves 171-184).<br>Affected members of the family investigated in this dissertation presented with photosensitivity and raised red cell protoporphyrin concentrations, indicative of protoporphyria. Further examination of this family revealed features that were atypical of erythropoietic protoporphyria. These included a highly penetrant disease, disease severity as expressed by more prevalent hepatic complications, a preponderance of protoporphyrin in its zinc chelated form, a therapeutic response to iron supplementation, and an absence of mutations in the f
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14

Williams, A. Lynn. "Phonology in Clinical Settings: It’s about Time." Digital Commons @ East Tennessee State University, 2004. https://dc.etsu.edu/etsu-works/2023.

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15

Elmedhem, Abdurrezagh Mansur. "Acute tubulo-interstitial nephritis : clinical profile and pathogenic mechanisms." Thesis, University of Birmingham, 2010. http://etheses.bham.ac.uk//id/eprint/570/.

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Acute tubulointerstitial nephritis (ATIN) is an important cause of renal morbidity. This study showed that it represents up to 8% of acute renal failure where biopsy material was available and accounted for 1% of all renal biopsy material. This study, which is believed to be the largest single retrospective study carried out to date, consists of 78 cases over nineteen years (1984-2002). Forty one cases were males and 37 were females. Acute tubulointerstitial nephritis (ATIN) was divided into three groups according to the cause: drug-induced ATIN, idiopathic ATIN and TINU syndrome. Drug-induced
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16

Ali, Asif. "Biomarkers for pancreatic cancer : identification, validation and clinical application." Thesis, University of Glasgow, 2015. http://theses.gla.ac.uk/6272/.

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Pancreatic cancer is common and aggressive: the main type is pancreatic ductal adenocarcinoma (PDAC). It is the fifth most common cause of cancer death in the UK with an overall five year survival of only 2-3%. Establishing the diagnosis of PDAC is important for optimal patient management but can be difficult and relies on imaging and cytology/pathology. Although imaging may be highly suggestive of PDAC, a pathological diagnosis is preferred prior to definitive treatment; therefore tissue samples are required. Cytology samples are obtained at endoscopy. Cytological analysis requires the identi
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17

Hotaling, Mary. "Effect of clinical laboratory practitioner licensing on wages." ScholarWorks, 2011. https://scholarworks.waldenu.edu/dissertations/860.

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Professional licensing directly affects about 29% of U.S. workers and is considered a primary means to establish and maintain health care practitioner competence. Clinical laboratory practitioner licensing was largely ignored in the literature with only 2 studies 30 years apart that provided conflicting conclusions regarding wage effects. This research provided the first study of clinical laboratory practitioner licensing effects on wages after controlling for human capital and individual characteristics wage determinants. This nonexperimental correlational study extended the literature on lic
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18

Mirabile, I. "Prion pathology in the brainstem : clinical target areas in prion disease." Thesis, University College London (University of London), 2012. http://discovery.ucl.ac.uk/1346475/.

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Prion diseases are fatal transmissible neurodegenerative disorders characterized by spongiform changes, neuronal loss, reactive astrocytosis, and deposition of disease associated prion protein (PrP). Our aim was to investigate "clinical target areas" for prion disease, responsible for disease onset, progression, and the clinical phenotype, using PrP overexpressing MloxP and PrP depleted NFH-Cre/MloxP transgenic mouse lines. Upon infection with different prion strains NFH-Cre/MloxP mice have significantly longer survival than MloxP mice (first set of experiments: Me7, ~29 weeks vs. ~17 weeks; M
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19

GUALA, ANDREA. "Mathematical modelling of cardiovascular fluid mechanics: physiology, pathology and clinical practice." Doctoral thesis, Politecnico di Torino, 2015. http://hdl.handle.net/11583/2615064.

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The cardiovascular apparatus is a complex dynamical system that carries oxygen and nutrients to cells, removes carbon dioxide and wastes and performs several other tasks essential for life. The physically-based modelling of the cardiovascular system has a long history, which begins with the simple lumped Windkessel model by O. Frank in 1899. Since then, the development has been impressive and a great variety of mathematical models have been proposed. The purpose of this Thesis is to analyse and develop two different mathematical models of the cardiovascular system able to (i) shed new
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20

Smurzynski, Jacek. "New Clinical Applications of Otoacoustic Emissions." Digital Commons @ East Tennessee State University, 2016. https://dc.etsu.edu/etsu-works/2158.

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21

Wenham, Philip R. "Multiple forms of γ-glutamyltransferase". Thesis, University of Edinburgh, 1985. http://hdl.handle.net/1842/19404.

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22

Williams, A. Lynn. "Making Phonology Functional: Assessment and Intervention in Clinical Settings." Digital Commons @ East Tennessee State University, 2003. https://dc.etsu.edu/etsu-works/2024.

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23

Williams, A. Lynn. "Making Phonology Functional: Assessment and Intervention in Clinical Settings." Digital Commons @ East Tennessee State University, 2000. https://dc.etsu.edu/etsu-works/2025.

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24

Innes, David Findlay. "The value of the autopsy in clinical medicine." Master's thesis, University of Cape Town, 1993. http://hdl.handle.net/11427/26604.

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The main purpose of this study was to assess the value of the autopsy in clinical medicine today. This has been achieved by analysing several variables. Clinical diagnostic accuracy was determined by assessing the concordance/discrepancy of clinical and autopsy diagnoses. In addition, several variables were assessed, namely whether or not the size of the hospital, type of ward, autopsy rate, age of the patient, and degree of confidence with which the clinical diagnosis was made had any bearing on the accuracy of the diagnosis. The impact of the newer diagnostic tests on clinical diagnosis was
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25

Akin, Faith W., and Owen D. Murnane. "ASHA Perspectives: Clinical Assessment of Otolith Function." Digital Commons @ East Tennessee State University, 2009. https://dc.etsu.edu/etsu-works/1794.

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The two otolith organs (the saccule and utricle) are positioned perpendicular to each other and sense linear acceleration, head tilt, and gravity, with the primary role of providing input to the vestibulospinal reflex for postural stability. The vestibulospinal reflex serves to modulate posture via two descending pathways that aid in tonic contractions of the antigravity muscles in the arms and legs (lateral vestibulospinal tract) and activate neck motoneurons for the coordination of neck and eye movements (medial vestibulospinal tract). The lateral vestibulospinal tract receives the majority
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26

Akin, Faith W. "Clinical Perspectives in Audiology: Cervical Vestibular Evoked Myogenic Potentials." Digital Commons @ East Tennessee State University, 2010. https://dc.etsu.edu/etsu-works/2442.

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This session was developed by Special Interest Division #6: Hearing & Hearing Disorders. Cervical vestibular evoked myogenic potentials (cVEMP) supplement the current vestibular test battery by providing diagnostic information about saccular and/ or inferior vestibular nerve function. The session will provide background, recording method, and clinical application of the cVEMP
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27

Joseph, Shari. "The neuropsychological risk factors associated with borderline pathology in children." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape11/PQDD_0006/MQ44192.pdf.

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Dronik, T. A. "Clinical markers of gastrointestinal disorders in newborns who have undergone perinatal pathology." Thesis, БДМУ, 2022. http://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/19797.

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29

Giori, L. "IDENTIFICATION OF NEW BIOMARKERS AND INNOVATIVE ANALYTICAL METHODS IN VETERINARY CLINICAL PATHOLOGY." Doctoral thesis, Università degli Studi di Milano, 2012. http://hdl.handle.net/2434/168079.

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Since laboratory tests are becoming more and more important in the diagnostic process even in the veterinary clinical practice, a specialist, able to manage the quality of the amount of work inside the laboratory itself, becomes a must. The main challenge for the clinical pathologist, when introducing instruments or new methods in the laboratory, is the “validation phase” to ensure that all the results show the real clinical condition of the patient rather than the variable analytical nature of the test itself. Diagnostic test or instrument validation is composed of four steps, including bot
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30

Murnane, Owen D. "Clinical Assessment of Otolith Organ Function." Digital Commons @ East Tennessee State University, 2015. https://dc.etsu.edu/etsu-works/1930.

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31

Arnold, Amanda, Lisa Phillips, Lindsay Pickler, Whitney White, Amanda McCamey, and Christopher McCrea. "Voice Onset Time as a Clinical Indicator of Hypofunctional Voice Disorders." Digital Commons @ East Tennessee State University, 2008. https://dc.etsu.edu/etsu-works/1960.

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The purpose of this study was to measure and compare the voice onset times (VOTs) of healthy individuals using a normal and breathy voice in an effort to determine if VOT can be used as a noninvasive clinical indicator of laryngeal function. Recordings were made of 20 adults between the ages of 20-48 with normal laryngeal function, each using a normal (Group 1) and breathy voice (Group 2). The participants’ productions were designed and collected in such a manner to control for speaking rate, vowel context, pitch, and loudness; all of which have been shown to influence VOT. A mixed analyses of
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Williams, A. Lynn, and T. Boggs. "Efficacy in Clinical Education: Comparison of Supervisory Models." Digital Commons @ East Tennessee State University, 2000. https://dc.etsu.edu/etsu-works/2100.

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Basich, Dinko. "The role of IL-4Rá in Nippostrongylus brasiliensis-induced chronic lung pathology." Master's thesis, University of Cape Town, 2010. http://hdl.handle.net/11427/13437.

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Includes bibliographical references (leaves 108-126).<br>Infection by the parasitic nematode Nippostrongylus brasiliensis involves migration through the lungs, causing significant damage and generating chronic lung pathology. The resolution of N. brasiliensis infection and also the induction of pulmonary pathology, including goblet cell hyperplasia and acute airway inflammation, depend on IL-4Rá signalling. A key feature of IL-4Rá signalling is the induction of a strong TH2 response which induces the development of alternatively activated macrophages (AAMs). AAMs are associated with tissue rem
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Reece, Benjamin K. "Facilitating collaborative supervision in a university speech-language pathology clinic." Scholarly Commons, 2020. https://scholarlycommons.pacific.edu/uop_etds/3667.

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Clinical education is a key element of graduate school training in the field of speech-language pathology. Graduate students are required to obtain 375 supervised clinical practice hours in order to earn their provisional license and begin their career. Supervision of clinical hours is most often provided by experienced speech-language pathologists with minimal, if any, training in effective supervision practices. Within the field of speech-language pathology, Anderson’s Continuum of Supervision (Anderson, 1988) is the most widely accepted model and provides a structure and sequence for supe
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35

Fagelson, Marc, and David M. Baguley. "Hyperacusis and Disorders of Sound Intolerance: Clinical and Research Perspectives." Digital Commons @ East Tennessee State University, 2018. https://dc.etsu.edu/etsu_books/190.

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Hyperacusis and Disorders of Sound Intolerance: Clinical and Research Perspectives is a professional resource for audiology practitioners involved in the clinical management of patients who suffer from sound tolerance concerns. The text covers emerging assessment and intervention strategies associated with hyperacusis, disorders of pitch perception, and other unusual processing deficits of the auditory system. In order to illustrate the patients perspectives and experiences with disorders of auditory processing, cases are included throughout. This collection of diagnostic strategies and tools,
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36

Cunningham, M., Faith W. Akin, Owen D. Murnane, C. Clinard, and J. Tampas. "The Clinical Evaluation Of Bilateral Vestibular Loss." Digital Commons @ East Tennessee State University, 2006. https://dc.etsu.edu/etsu-works/1896.

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37

Akin, Faith W., Owen D. Murnane, and T. Medley. "Clinical Application of Vestibular Evoked Myogenic Potentials." Digital Commons @ East Tennessee State University, 2002. https://dc.etsu.edu/etsu-works/1910.

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38

Mohammed, Mohammed Zubair Khuder. "Pre-clinical development of human apurinic/apyrimidinic endonuclease (APE1) inhibitors for cancer therapy." Thesis, University of Nottingham, 2011. http://eprints.nottingham.ac.uk/13980/.

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Modulation of DNA base excision repair (BER) has the potential to enhance response to chemotherapy and improve outcomes in tumours such as melanoma, glioma and pancreatic cancer. APE1, a critical protein in BER that processes potentially cytotoxic abasic sites (AP sites), is a promising new target in cancer. In the current study, my aim was to develop small molecule inhibitors of APE1 for cancer therapy. An industry-standard high throughput virtual screening strategy was adopted. The SYBYL8.0 (Tripos, St Louis, MO, USA) molecular modelling software suite was used to build inhibitor templates.
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Cardozo, Karin. "Speech-Language Pathology Interns’ Perceptions of What Supervisors Value Most During Clinical Practicum." FIU Digital Commons, 2015. http://digitalcommons.fiu.edu/etd/2276.

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The purpose of this investigation was to analyze interns’ perceptions of what supervisors considered important supervisory behaviors and to compare those perceptions with what the supervisors considered important. Participants consisted of 33 interns and 23 supervisors. Results of two surveys collected in previous studies were compared and analyzed. Tihen’s (1983) “Tihen’s Student Expectations of their Clinical Supervisor(s) Scale” was used for the intern group. A modified version of the same scale was used for the supervisor group. The scale rated five domains: passive, evaluative, active, co
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40

Namati, Eman, and eman@namati com. "Pre-Clinical Multi-Modal Imaging for Assessment of Pulmonary Structure, Function and Pathology." Flinders University. Computer Science, Engineering and Mathematics, 2008. http://catalogue.flinders.edu.au./local/adt/public/adt-SFU20081013.044657.

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In this thesis, we describe several imaging techniques specifically designed and developed for the assessment of pulmonary structure, function and pathology. We then describe the application of this technology within appropriate biological systems, including the identification, tracking and assessment of lung tumors in a mouse model of lung cancer. The design and development of a Large Image Microscope Array (LIMA), an integrated whole organ serial sectioning and imaging system, is described with emphasis on whole lung tissue. This system provides a means for acquiring 3D pathology of fixed w
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41

Barnett, Sue. "The clinical effectiveness of orthoses prescribed to control and reduce diabetic foot pathology." Thesis, University of the West of England, Bristol, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.249150.

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42

Anokhina, A. "Implicit attitudes towards food and the self in sub-clinical eating disorder pathology." Thesis, University College London (University of London), 2015. http://discovery.ucl.ac.uk/1464573/.

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This thesis focuses on the assessment of implicit cognition in disordered eating behaviour, and specifically on the role of implicit attitudes towards the self and food in sub-clinical levels of eating disorder (ED) pathology. Chapter I reviews key theoretical approaches to implicit cognition and an assessment of the properties of implicit attitudes. Chapter II discusses methodological approaches to implicit attitude assessment, with a focus on the Implicit Attitude Test (IAT) which was used in the empirical studies. Chapter III (Study 1) outlines research in implicit cognition in ED pathology
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43

Start, Roger David. "Attitudes towards autopsy." Thesis, University of Sheffield, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.285544.

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44

McAllister, Sue Margery. "Competency based assessment of speech pathology students' performance in the workplace." University of Sydney, 2005. http://hdl.handle.net/2123/1130.

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Doctor of Philosophy (PhD)<br>Ensuring that speech pathology students are sufficiently competent to practise their profession is of critical importance to the speech pathology profession, students, their future employers, and clients/patients. This thesis describes the development and validation of a competency based assessment of speech pathology students’ performance in the workplace and their readiness to enter the profession. Development involved an extensive literature review regarding the nature of competency and its relationship to professional practice, the purpose and nature of assess
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45

Algahtani, Mohammad. "Development of platelet function analysis for use in haematological and clinical investigations." Thesis, University of Nottingham, 2016. http://eprints.nottingham.ac.uk/33393/.

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Platelets are highly specialised cells that play a pivotal role in the regulation of haemostasis and thrombosis. Accurate measurement of platelet function is important in identifying patients with platelet abnormalities: for example, platelet hyperfunction, which may result in hyperthrombotic risk, or platelet hypofunction, which may lead to enhanced bleeding. Also, accurate measurement is becoming crucial for assessing the adequacy of treatment with antiplatelet therapy. Platelet function testing to assess the efficacy of antiplatelet drugs is becoming widely used and a range of assays has be
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46

Williams, A. Lynn, Jan Edwards, Benjamin Munson, Amy Glaspey, and Shelley Velleman. "Assessment of Speech Sound Disorders: Clinical Decision Making." Digital Commons @ East Tennessee State University, 2013. https://dc.etsu.edu/etsu-works/2055.

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This session is developed by, and presenters invited by Speech Sound Disorders in Children. A case-based approach will be used to assess the complexity of SSD through assessment and analysis measures that guide clinical decisions regarding differential diagnosis, intervention planning, and progress monitoring.
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47

Johnson, Robyn Bethany. "We all hate the ‘F’ word, but some speech pathology students do fail clinic: can this difficulty developing clinical competence be predicted?" Thesis, The University of Sydney, 2021. https://hdl.handle.net/2123/25468.

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All speech pathology (SP) students in Australia must achieve entry-level clinical competence at the end of their degrees to graduate and enter the profession. Little is known about predictors of competence development. This thesis describes three reviews and four studies investigating predictors of the difficulty developing competence some students experience, with Astin’s Input-Environment-Output (I-E-O) model as a conceptual framework. A mixed methods approach was used to answer the questions informed by the narrative review: What input and environment factors contribute to students’ diffi
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48

Black, Deborah Naomi. "Familial leukoencephalopathy in Chisasibi, Nouveau Québec : clinical epidemiological, and genetic aspects." Thesis, McGill University, 1986. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=61267.

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Two distinct patterns of neurological disease have been identified among Cree Indian children in Chisasibi, Nouveau Quebec and among Native Indian infants in Northern Manitoba. Both affect the cerebral white matter. The fifteen patients in the first group may suffer from an autosomal recessive defect causing defective development of cerebral myelin. The eleven patients in the second group have systemic immune dysfunction and meningoencephalitis. Together, these diseases are responsible for over half the deaths of infants and young children in Chisasibi. Inbreeding, and the familial occurrence
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49

Smurzynski, Jacek. "Otoacoustic Emissions: Recent Advances in Research and in Clinical Applications." Digital Commons @ East Tennessee State University, 2007. https://dc.etsu.edu/etsu-works/2164.

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Williams, A. Lynn, R. Epperly, J. R. Rodgers, and L. Feltes. "Treatment Efficacy in Phonological Intervention: Clinical Case Studies." Digital Commons @ East Tennessee State University, 1999. https://dc.etsu.edu/etsu-works/2102.

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