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Artykuły w czasopismach na temat „Clonal fitness”

Autor: Grafiati

Data publikacji: 14 grudnia 2024

Data aktualizacji: 31 lipca 2025

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1

Wikberg, Sofie. "Fitness in Clonal Plants." Oikos 72, no. 2 (1995): 293. http://dx.doi.org/10.2307/3546232.

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Watson, Caroline J., A. L. Papula, Gladys Y. P. Poon, et al. "The evolutionary dynamics and fitness landscape of clonal hematopoiesis." Science 367, no. 6485 (2020): 1449–54. http://dx.doi.org/10.1126/science.aay9333.

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Somatic mutations acquired in healthy tissues as we age are major determinants of cancer risk. Whether variants confer a fitness advantage or rise to detectable frequencies by chance remains largely unknown. Blood sequencing data from ~50,000 individuals reveal how mutation, genetic drift, and fitness shape the genetic diversity of healthy blood (clonal hematopoiesis). We show that positive selection, not drift, is the major force shaping clonal hematopoiesis, provide bounds on the number of hematopoietic stem cells, and quantify the fitness advantages of key pathogenic variants, at single-nuc

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Burns, Thomas P. "Fitness in Clonal Organisms: A Special Case of Extensive Fitness." Oikos 65, no. 3 (1992): 535. http://dx.doi.org/10.2307/3545572.

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Pan, Jean J., and Jason S. Price. "Fitness and evolution in clonal plants: the impact of clonal growth." Evolutionary Ecology 15, no. 4-6 (2001): 583–600. http://dx.doi.org/10.1023/a:1016065705539.

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Barrett, Spencer C. H. "Influences of clonality on plant sexual reproduction." Proceedings of the National Academy of Sciences 112, no. 29 (2015): 8859–66. http://dx.doi.org/10.1073/pnas.1501712112.

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Flowering plants possess an unrivaled diversity of mechanisms for achieving sexual and asexual reproduction, often simultaneously. The commonest type of asexual reproduction is clonal growth (vegetative propagation) in which parental genotypes (genets) produce vegetative modules (ramets) that are capable of independent growth, reproduction, and often dispersal. Clonal growth leads to an expansion in the size of genets and increased fitness because large floral displays increase fertility and opportunities for outcrossing. Moreover, the clonal dispersal of vegetative propagules can assist “mate

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6

Avagyan, S., J. E. Henninger, W. P. Mannherz, et al. "Resistance to inflammation underlies enhanced fitness in clonal hematopoiesis." Science 374, no. 6568 (2021): 768–72. http://dx.doi.org/10.1126/science.aba9304.

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Colorful clones in the blood Stem cells in regenerating tissues such as the blood can acquire mutations that enable a growth advantage, increasing the chance of developing cancer. It is unclear how such diverse mutations promote clonal fitness. Avagyan et al . generated a platform in zebrafish to label clones with unique hues while inducing mutations in genes implicated in human blood disorders. Mutations in some genes caused clones to expand over time, resulting in clonal dominance. Progenitors in the dominant clone expressed anti-inflammatory factors to resist the inflammatory environment pr

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Skums, Pavel, Viachaslau Tsyvina, and Alex Zelikovsky. "Inference of clonal selection in cancer populations using single-cell sequencing data." Bioinformatics 35, no. 14 (2019): i398—i407. http://dx.doi.org/10.1093/bioinformatics/btz392.

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Abstract Summary Intra-tumor heterogeneity is one of the major factors influencing cancer progression and treatment outcome. However, evolutionary dynamics of cancer clone populations remain poorly understood. Quantification of clonal selection and inference of fitness landscapes of tumors is a key step to understanding evolutionary mechanisms driving cancer. These problems could be addressed using single-cell sequencing (scSeq), which provides an unprecedented insight into intra-tumor heterogeneity allowing to study and quantify selective advantages of individual clones. Here, we present Sing

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8

Derbal, Youcef. "Cell Adaptive Fitness and Cancer Evolutionary Dynamics." Cancer Informatics 22 (January 2023): 117693512311546. http://dx.doi.org/10.1177/11769351231154679.

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Genome instability of cancer cells translates into increased entropy and lower information processing capacity, leading to metabolic reprograming toward higher energy states, presumed to be aligned with a cancer growth imperative. Dubbed as the cell adaptive fitness, the proposition postulates that the coupling between cell signaling and metabolism constrains cancer evolutionary dynamics along trajectories privileged by the maintenance of metabolic sufficiency for survival. In particular, the conjecture postulates that clonal expansion becomes restricted when genetic alterations induce a suffi

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9

Fuzi, Miklos, and Evgeni Sokurenko. "Commensal Fitness Advantage May Contribute to the Global Dissemination of Multidrug-Resistant Lineages of Bacteria—The Case of Uropathogenic E. coli." Pathogens 12, no. 9 (2023): 1150. http://dx.doi.org/10.3390/pathogens12091150.

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It is widely accepted that favorable fitness in commensal colonization is one of the prime facilitators of clonal dissemination in bacteria. The question arises as to what kind of fitness advantage may be wielded by uropathogenic strains of the two predominant fluoroquinolone- and multidrug-resistant clonal groups of E. coli—ST131-H30 and ST1193, which has permitted their unprecedented pandemic-like global expansion in the last few decades. The colonization-associated genes’ content, carriage of low-cost plasmids, and integrons with weak promoters could certainly contribute to the fitness of t

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10

Gordo, Isabel, and Paulo R. A. Campos. "Evolution of clonal populations approaching a fitness peak." Biology Letters 9, no. 1 (2013): 20120239. http://dx.doi.org/10.1098/rsbl.2012.0239.

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Populations facing novel environments are expected to evolve through the accumulation of adaptive substitutions. The dynamics of adaptation depend on the fitness landscape and possibly on the genetic background on which new mutations arise. Here, we model the dynamics of adaptive evolution at the phenotypic and genotypic levels, focusing on a Fisherian landscape characterized by a single peak. We find that Fisher's geometrical model of adaptation, extended to allow for small random environmental variations, is able to explain several features made recently in experimentally evolved populations

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11

Demetrio, Guilherme Ramos, Dalton Serafim, and Flávia de Freitas Coelho. "Is Clonal Integration a Buffer for the Stress of Resource Acquisition Depletion in Eichhornia crassipes (Pontederiaceae) Ramets?" Stresses 4, no. 4 (2024): 734–43. http://dx.doi.org/10.3390/stresses4040047.

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Natural selection favors the allocation of finite resources to different functions maximizing fitness. In this sense, some functions may decrease whereas others increase when resources are limited in a process called a trade-off. However, a great variety of situations may obscure trade-off detection in clonal plants, such as the ability to generate offspring by clonal growth that represents opportunities for resource uptake. The aim of this work was to evaluate if clonal integration and resource availability mediate biomass allocation patterns in E. crassipes through a greenhouse experiment. W

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12

Dorken, Marcel E., and Wendy E. Van Drunen. "Sex allocation in clonal plants: might clonal expansion enhance fitness gains through male function?" Evolutionary Ecology 24, no. 6 (2010): 1463–74. http://dx.doi.org/10.1007/s10682-010-9393-2.

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Traulsen, Arne, Tom Lenaerts, Jorge M. Pacheco, and David Dingli. "On the dynamics of neutral mutations in a mathematical model for a homogeneous stem cell population." Journal of The Royal Society Interface 10, no. 79 (2013): 20120810. http://dx.doi.org/10.1098/rsif.2012.0810.

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The theory of the clonal origin of cancer states that a tumour arises from one cell that acquires mutation(s) leading to the malignant phenotype. It is the current belief that many of these mutations give a fitness advantage to the mutant population allowing it to expand, eventually leading to disease. However, mutations that lead to such a clonal expansion need not give a fitness advantage and may in fact be neutral—or almost neutral—with respect to fitness. Such mutant clones can be eliminated or expand stochastically, leading to a malignant phenotype (disease). Mutations in haematopoietic s

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14

Kirschner, Kristina, Simon Cox, Tamir Chandra Neil Robertson Eric Crespo, and Linus Schumacher. "FITNESS AND TIME OF MUTATION ACQUISITION A BETTER PREDICTOR OF OUTCOME IN CLONAL HEMOPOIESIS COMPARED TO CLONE SIZE." Innovation in Aging 8, Supplement_1 (2024): 445. https://doi.org/10.1093/geroni/igae098.1448.

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Abstract The prevalence of clonal hematopoiesis of indeterminate potential (CHIP) in healthy individuals increases rapidly from age 60 onwards and has been associated with increased risk for malignancy, heart disease and ischemic stroke. CHIP is driven by somatic mutations in stem cells that are also drivers of myeloid malignancies. We previously reported gene specific fitness effects in two longitudinal cohorts of aging. We now set out to define fitness effects across three longitudinal cohorts of aging in a total of 713 participants. We found that fitness correlates with timing of mutations,

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15

Avagyan, Serine, Jonathan E. Henninger, William P. Mannherz, et al. "Loss of nr4a1 abrogates Fitness of asxl1-mutant Hematopoietic Clones." Blood 138, Supplement 1 (2021): 3272. http://dx.doi.org/10.1182/blood-2021-149731.

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Abstract Clonal fitness of mutant hematopoietic stem and progenitor cells (HSPCs) underlies clonal hematopoiesis (CH), a state of clonal expansion associated with increased risk of blood malignancies and cardiovascular disease. Mechanisms by which acquired mutations lead to clonal fitness are not known. We used a zebrafish model to study the effect of acquired asxl1 mutations on HSPC clonality with TWISTR (Tissue editing With Inducible Stem cell Tagging via Recombination) that combined mosaic CRISPR-Cas9 mutagenesis with color labeling of HSPC clones. TWISTR asxl1 mutants showed clonal dominan

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16

Viny, Aaron D. "DNMT3A-Mutant Leukemia Cells Primed to “Fork It Over” under DNA Damage." Clinical Cancer Research 28, no. 4 (2021): 573–75. http://dx.doi.org/10.1158/1078-0432.ccr-21-3949.

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Summary Mutations in the gene DNMT3A have been identified in various hematopoietic conditions, including clonal hematopoiesis, myelodysplastic syndrome, and acute myeloid leukemia. The clinical significance of this early mutation and the resultant enhanced clonal fitness have been a focus for therapeutic intervention. See related article by Venugopal et al., p. 756

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17

Van Drunen, Wendy E., Mark van Kleunen, and Marcel E. Dorken. "Consequences of clonality for sexual fitness: Clonal expansion enhances fitness under spatially restricted dispersal." Proceedings of the National Academy of Sciences 112, no. 29 (2015): 8929–36. http://dx.doi.org/10.1073/pnas.1501720112.

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Clonality is a pervasive feature of sessile organisms, but this form of asexual reproduction is thought to interfere with sexual fitness via the movement of gametes among the modules that comprise the clone. This within-clone movement of gametes is expected to reduce sexual fitness via mate limitation of male reproductive success and, in some cases, via the production of highly inbred (i.e., self-fertilized) offspring. However, clonality also results in the spatial expansion of the genetic individual (i.e., genet), and this should decrease distances gametes and sexually produced offspring must

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18

Bingham, Brian L., James L. Dimond, and Gisèle Muller-Parker. "Symbiotic state influences life-history strategy of a clonal cnidarian." Proceedings of the Royal Society B: Biological Sciences 281, no. 1789 (2014): 20140548. http://dx.doi.org/10.1098/rspb.2014.0548.

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Along the North American Pacific coast, the common intertidal sea anemone Anthopleura elegantissima engages in facultative, flexible symbioses with Symbiodinium muscatinei (a dinoflagellate) and Elliptochloris marina (a chlorophyte). Determining how symbiotic state affects host fitness is essential to understanding the ecological significance of engaging in such flexible relationships with diverse symbionts. Fitness consequences of hosting S. muscatinei , E. marina or negligible numbers of either symbiont (aposymbiosis) were investigated by measuring growth, cloning by fission and gonad develo

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19

Kato, Masayasu, Eduardo S. Mizubuti, Stephen B. Goodwin, and William E. Fry. "Sensitivity to Protectant Fungicides and Pathogenic Fitness of Clonal Lineages of Phytophthora infestans in the United States." Phytopathology® 87, no. 9 (1997): 973–78. http://dx.doi.org/10.1094/phyto.1997.87.9.973.

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Since 1991, dramatic changes have occurred in the genetic composition of populations of Phytophthora infestans in the United States. Clonal lineages recently introduced into the United States (US-7 and US-8) are more common now than the previously dominant lineage (US-1). To help determine why these changes occurred, four clonal lineages of P. in-festans common during the early 1990s in the United States and Canada were evaluated for sensitivity to the protectant fungicides mancozeb and chlorothalonil using amended agar assays for isolates collected from 1990 to 1994. No isolate or lineage was

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20

MURRAY, J. L. S., and PETER A. JUMARS. "Clonal Fitness of Attached Bacteria Predicted by Analog Modeling." BioScience 52, no. 4 (2002): 343. http://dx.doi.org/10.1641/0006-3568(2002)052[0343:cfoabp]2.0.co;2.

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Bolton, Kelly L., Ryan N. Ptashkin, Teng Gao, et al. "Cancer therapy shapes the fitness landscape of clonal hematopoiesis." Nature Genetics 52, no. 11 (2020): 1219–26. http://dx.doi.org/10.1038/s41588-020-00710-0.

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Pedersen, Bård, Juha Tuomi, and Bard Pedersen. "Hierarchical Selection and Fitness in Modular and Clonal Organisms." Oikos 73, no. 2 (1995): 167. http://dx.doi.org/10.2307/3545905.

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23

Hodgson, D. J. "Monoclonal aphid colonies and the measurement of clonal fitness." Ecological Entomology 26, no. 4 (2001): 444–48. http://dx.doi.org/10.1046/j.1365-2311.2001.00327.x.

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24

Frede, Julia, David J. Adams, and Philip H. Jones. "Mutation, clonal fitness and field change in epithelial carcinogenesis." Journal of Pathology 234, no. 3 (2014): 296–301. http://dx.doi.org/10.1002/path.4409.

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Fam, D. F., S. P. Koh, Tiong Sieh Kiong, and K. H. Chong. "Comparative Analysis of Selective Clonal Mutation with Conventional GA Operators in Solar Tracking Environment." Advanced Materials Research 341-342 (September 2011): 456–61. http://dx.doi.org/10.4028/www.scientific.net/amr.341-342.456.

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Genetic Algorithm (GA) belongs to elementary stochastic optimization algorithms inspired by evolution.It points out the ability of simple representations using bit strings to encode complicated structures and the power of simple transformations to reach the desired solution. Research shows that a new operator namely Selective Clonal Mutation (SCM) for better genetic solutions has been successfully developed so that faster convergence to the best desired solution could be obtained. This operator has produced the best fitness value as compared to the conventional genetic algorithm result within

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Link, Daniel C. "Clonal Evolution During Stress Hematopoiesis." Blood 130, Suppl_1 (2017): SCI—38—SCI—38. http://dx.doi.org/10.1182/blood.v130.suppl_1.sci-38.sci-38.

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Hematopoietic stem and progenitor cells (HSPCs) acquire somatic mutations with age resulting in a heterogeneous cell population, with each HSPC possessing its own unique set of private mutations. HSPCs that acquire somatic mutations that confer a competitive fitness advantage relative to their normal counterparts may clonally expand. Indeed, several groups have documented the presence of clonal hematopoiesis in healthy individuals. Although originally thought to be limited to older individuals, a recent study using an ultra-sensitive sequencing technique showed that expanded hematopoietic clon

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Miller, Peter G., Christopher J. Gibson, Arnav Mehta, et al. "Fitness Landscape of Clonal Hematopoiesis Under Selective Pressure of Immune Checkpoint Blockade." JCO Precision Oncology, no. 4 (September 2020): 1027–33. http://dx.doi.org/10.1200/po.20.00186.

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PURPOSE Conventional cytotoxic therapies increase the risk of clonal hematopoiesis and select for TP53-mutant clones, which carry a high risk for transformation to therapy-related myelodysplastic neoplasms. In contrast, the effect of immune checkpoint blockade (ICB) on clonal hematopoiesis is unknown. METHODS Paired peripheral-blood samples taken before and after treatment with ICB were obtained for 91 patients with either cutaneous melanoma or basal cell carcinoma. Error-corrected sequencing of a targeted panel of genes recurrently mutated in clonal hematopoiesis was performed on peripheral-b

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Ho, I.-Lin, Chieh-Yuan Li, Fuchenchu Wang, et al. "Abstract 1494: Clonal dominance defines metastatic dissemination in pancreatic cancer." Cancer Research 84, no. 6_Supplement (2024): 1494. http://dx.doi.org/10.1158/1538-7445.am2024-1494.

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Abstract Tumors represent ecosystems where subclones compete during tumor growth. While extensively investigated, a comprehensive picture of the interplay of clonal lineages during dissemination is still lacking. Using patient-derived pancreatic cancer cells, we created orthotopically-implanted clonal replica tumors to trace clonal dynamics of unperturbed tumor expansion and dissemination. This model revealed the multifaceted nature of tumor growth, with rapid changes in clonal fitness leading to continuous reshuffling of tumor architecture and alternating clonal dominance as a distinct featur

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Seidl Johnson, Anna C., Kenneth E. Frost, Douglas I. Rouse, and Amanda J. Gevens. "Effect of Temperature on Growth and Sporulation of US-22, US-23, and US-24 Clonal Lineages of Phytophthora infestans and Implications for Late Blight Epidemiology." Phytopathology® 105, no. 4 (2015): 449–59. http://dx.doi.org/10.1094/phyto-03-14-0064-r.

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Epidemics of late blight, caused by Phytophthora infestans (Mont.) de Bary, have been studied by plant pathologists and regarded with great concern by potato and tomato growers since the Irish potato famine in the 1840s. P. infestans populations have continued to evolve, with unique clonal lineages arising which differ in pathogen fitness and pathogenicity, potentially impacting epidemiology. In 2012 and 2013, the US-23 clonal lineage predominated late blight epidemics in most U.S. potato and tomato production regions, including Wisconsin. This lineage was unknown prior to 2009. For isolates o

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Testa, Ugo, Germana Castelli, and Elvira Pelosi. "Clonal Hematopoiesis, a Risk Condition for Developing Myeloid Neoplasia." Hemato 6, no. 2 (2025): 10. https://doi.org/10.3390/hemato6020010.

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Clonal hematopoiesis (CH) is an age-related process in which hematopoietic stem/progenitor cells increase their fitness due to the acquisition of mutations that lead to a proliferative advantage and to clonal expansion. Its frequency increases with age, and it mostly affects people older than 70 years. The most mutated genes in CH are epigenetic regulators, DNA damage response genes, and splicing factors, which are all involved in the development of myeloid neoplasia. Some risk factors, including age, smoking, and prior cytotoxic therapy, increase the risk of developing CH or increase the fitn

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Wong, Terrence Neal, Jeffery M. Klco, Ryan Demeter, et al. "Non-Malignant Oligoclonal Hematopoiesis Commonly Follows Cytoreductive Chemotherapy in Adult De Novo AML Patients." Blood 126, no. 23 (2015): 686. http://dx.doi.org/10.1182/blood.v126.23.686.686.

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Abstract Our group (Welch, Cell 2012) previously showed that hematopoietic stem and progenitor cells (HSPCs) acquire somatic mutations with age. This produces a genetically heterogeneous HSPC population with each HSPC possessing its own unique set of mutations. Later work from our group (Xie, Nature Medicine 2014) and others (Genovese, Jaiswal, NEJM 2014) demonstrated that some these mutations may provide HSPCs with a fitness advantage, allowing them to clonally expand over time in healthy individuals. We recently published data (Wong, Nature 2015) suggesting that cytotoxic therapy can select

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Weaver, Scott C., Aaron C. Brault, Wenli Kang, and John J. Holland. "Genetic and Fitness Changes Accompanying Adaptation of an Arbovirus to Vertebrate and Invertebrate Cells." Journal of Virology 73, no. 5 (1999): 4316–26. http://dx.doi.org/10.1128/jvi.73.5.4316-4326.1999.

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ABSTRACT The alternating host cycle and persistent vector infection may constrain the evolution of arboviruses. To test this hypothesis, eastern equine encephalitis virus was passaged in BHK or mosquito cells, as well as in alternating (both) host cell passages. High and low multiplicities were used to examine the effect of defective interfering particles. Clonal BHK and persistent mosquito cell infections were also evaluated. Fitness was measured with one-step growth curves and competition assays, and mutations were evaluated by nucleotide sequencing and RNA fingerprinting. All passages and a

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Vorburger, C., and N. Ramsauer. "Genetic variation and covariation of aphid life-history traits across unrelated host plants." Bulletin of Entomological Research 98, no. 6 (2008): 543–53. http://dx.doi.org/10.1017/s0007485308005853.

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AbstractA central paradigm of life-history theory is the existence of resource mediated trade-offs among different traits that contribute to fitness, yet observations inconsistent with this tenet are not uncommon. We previously found a clonal population of the aphid Myzus persicae to exhibit positive genetic correlations among major components of fitness, resulting in strong heritable fitness differences on a common host. This raises the question of how this genetic variation is maintained. One hypothesis states that variation for resource acquisition on different hosts may override variation

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Huber, Meret, Saskia Gablenz, and Martin Höfer. "Transgenerational non-genetic inheritance has fitness costs and benefits under recurring stress in the clonal duckweed Spirodela polyrhiza." Proceedings of the Royal Society B: Biological Sciences 288, no. 1955 (2021): 20211269. http://dx.doi.org/10.1098/rspb.2021.1269.

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Although non-genetic inheritance is thought to play an important role in plant ecology and evolution, evidence for adaptive transgenerational plasticity is scarce. Here, we investigated the consequences of copper excess on offspring defences and fitness under recurring stress in the duckweed Spirodela polyrhiza across multiple asexual generations . Growing large monoclonal populations (greater than 10 000 individuals) for 30 generations under copper excess had negative fitness effects after short and no fitness effect after prolonged growth under recurring stress. These time-dependent growth r

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Jaiswal, Siddhartha, and Benjamin L. Ebert. "Clonal hematopoiesis in human aging and disease." Science 366, no. 6465 (2019): eaan4673. http://dx.doi.org/10.1126/science.aan4673.

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As people age, their tissues accumulate an increasing number of somatic mutations. Although most of these mutations are of little or no functional consequence, a mutation may arise that confers a fitness advantage on a cell. When this process happens in the hematopoietic system, a substantial proportion of circulating blood cells may derive from a single mutated stem cell. This outgrowth, called “clonal hematopoiesis,” is highly prevalent in the elderly population. Here we discuss recent advances in our knowledge of clonal hematopoiesis, its relationship to malignancies, its link to nonmaligna

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Watson, Caroline J., Sophia Apostolidou, Usha Menon, and Jamie R. Blundell. "Tracing the Evolution of Clonal Hematopoiesis to AML Using Longitudinal Pre-Diagnosis Blood Samples." Blood 138, Supplement 1 (2021): 599. http://dx.doi.org/10.1182/blood-2021-147503.

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Abstract The acquisition of somatic mutations in hematopoietic stem and progenitor cells (HSPCs) is increasingly common with age (`clonal hematopoiesis'). If sequential acquisition and clonal expansion of mutations occurs, progression to Acute Myeloid Leukemia (AML) can occur. While the mutational landscape of clonal hematopoiesis antecedent to AML development has been well-defined (Abelson et al. 2018, Desai et al. 2018), the timing of acquisition and growth dynamics of these high-risk mutations remain largely unknown. At what age are these mutations acquired? Are the fitness effects (growth

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Fennell, Katie A., Dane Vassiliadis, Enid Y. N. Lam, et al. "Non-genetic determinants of malignant clonal fitness at single-cell resolution." Nature 601, no. 7891 (2021): 125–31. http://dx.doi.org/10.1038/s41586-021-04206-7.

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Hughes, D. J. "Genotype-Environment Interactions and Relative Clonal Fitness in a Marine Bryozoan." Journal of Animal Ecology 61, no. 2 (1992): 291. http://dx.doi.org/10.2307/5322.

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Frick, Peter L., Bishal B. Paudel, Darren R. Tyson, and Vito Quaranta. "Quantifying heterogeneity and dynamics of clonal fitness in response to perturbation." Journal of Cellular Physiology 230, no. 7 (2015): 1403–12. http://dx.doi.org/10.1002/jcp.24888.

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Ajisebutu, A., F. Fan, C. Gui, et al. "F.2 Single cell CRISPR/Cas-9 lineage tracing reveals fitness axis in glioblastoma." Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques 52, s1 (2025): S14. https://doi.org/10.1017/cjn.2025.10180.

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Background: We’ve adopted a novel approach that combines cellular barcoding with CRISPR/Cas-9 technology and single-cell RNA sequencing known as continuous lineage tracing to track the development, treatment and inevitable recurrence of glioblastoma. Methods: Patient derived glioma initiating cell lines were engineered with expressed DNA barcodes with CRISPR/Cas-9 targets and engrafted into NOD scid-mice. Clonal and relationships are surmised through identification of expressed barcodes, and cells were characterized by their transcriptional profiles. Phylogenetic lineage trees are created usin

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Willi, Yvonne, and Josh Van Buskirk. "Genomic compatibility occurs over a wide range of parental genetic similarity in an outcrossing plant." Proceedings of the Royal Society B: Biological Sciences 272, no. 1570 (2005): 1333–38. http://dx.doi.org/10.1098/rspb.2005.3077.

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The theory of inbreeding and outbreeding suggests that there is a hump-shaped relationship between the genetic similarity of sexually reproducing parents and the performance of their offspring. Inbreeding depression occurs when genetic similarity is high, whereas hybrid breakdown is expected when genetic similarity is low. Between these extremes, the effect of genetic similarity on fitness is unclear. We studied the shape of this relationship by crossing 65 target genotypes of the clonal, self-incompatible Ranunculus reptans with partner genotypes spanning a broad scale of genetic similarity,

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Laruelle, Annick, Claudia Manini, José I. López, and André Rocha. "Early Evolution in Cancer: A Mathematical Support for Pathological and Genomic Evidence in Clear Cell Renal Cell Carcinoma." Cancers 15, no. 24 (2023): 5897. http://dx.doi.org/10.3390/cancers15245897.

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Clear cell renal cell carcinoma (CCRCC) is an aggressive form of cancer and a paradigmatic example of intratumor heterogeneity (ITH). The hawk-dove game is a mathematical tool designed to analyze competition in biological systems. Using this game, the study reported here analyzes the early phase of CCRCC development, comparing clonal fitness in homogeneous (linear evolutionary) and highly heterogeneous (branching evolutionary) models. Fitness in the analysis is a measure of tumor aggressiveness. The results show that the fittest clone in a heterogeneous environment is fitter than the clone in

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Elena, Santiago F., Fernando González-Candelas, Isabel S. Novella, et al. "Evolution of Fitness in Experimental Populations of Vesicular Stomatitis Virus." Genetics 142, no. 3 (1996): 673–79. http://dx.doi.org/10.1093/genetics/142.3.673.

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Abstract The evolution of fitness in experimental clonal populations of vesicular stomatitis virus (VSV) has been compared under different genetic (fitness of initial clone) and demographic (population dynamics) regimes. In spite of the high genetic heterogeneity among replicates within experiments, there is a clear effect of population dynamics on the evolution of fitness. Those populations that went through strong periodic bottlenecks showed a decreased fitness in competition experiments with wild type. Conversely, mutant populations that were transferred under the dynamics of continuous pop

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Petrone, Giulia, Isik Turker, Pradeep Natarajan, and Kelly L. Bolton. "Clinical and Therapeutic Implications of Clonal Hematopoiesis." Annual Review of Genomics and Human Genetics 25, no. 1 (2024): 329–51. http://dx.doi.org/10.1146/annurev-genom-120722-100409.

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Clonal hematopoiesis (CH) is an age-related process whereby hematopoietic stem and progenitor cells (HSPCs) acquire mutations that lead to a proliferative advantage and clonal expansion. The most commonly mutated genes are epigenetic regulators, DNA damage response genes, and splicing factors, which are essential to maintain functional HSPCs and are frequently involved in the development of hematologic malignancies. Established risk factors for CH, including age, prior cytotoxic therapy, and smoking, increase the risk of acquiring CH and/or may increase CH fitness. CH has emerged as a novel ri

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Demetrio, Guilherme Ramos, Luziene Seixas, and Flávia de Freitas Coelho. "Flower Position and Clonal Integration Drive Intra-Individual Floral Trait Variation in Water-Hyacinth (Eichhornia crassipes, Pontederiaceae)." Biology 14, no. 2 (2025): 114. https://doi.org/10.3390/biology14020114.

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Intra-individual variation in floral traits is linked to plant fitness, playing a central role in sexual selection. This variation can arise from architectural constraints, such as flower position on the inflorescence axis, and from environmental factors. In relation to the environmental influences on floral traits, the most common causes of variation are linked to the presence of pollinators, to plant resource acquisition strategies and to the availability of local resource pools. We investigated how clonal integration and resource depletion through defoliation affect floral trait stability i

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Samadzadegan, Farhad, Shahin Rahmatollahi Namin, and Mohammad Ali Rajabi. "Evaluating the Potential of Clonal Selection Optimization Algorithm to Hyperspectral Image Feature Selection." Key Engineering Materials 500 (January 2012): 799–805. http://dx.doi.org/10.4028/www.scientific.net/kem.500.799.

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The great number of captured near spectral bands in hyperspectral images causes the curse of dimensionality problem and results in low classification accuracy. The feature selection algorithms try to overcome this problem by limiting the input space dimensions of classification for hyperspectral images. In this paper, immune clonal selection optimization algorithm is used for feature selection. Also one of the fastest Artificial Immune classification algorithms is used to compute fitness function of the feature selection. The comparison of the feature selection results with genetic algorithm s

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Naddaf, Lamis, Marco De Dominici, Xiaowen Chen, et al. "Title: In Vivo Clonal Tracing of Hematopoietic Stem and Progenitor Cells Reveals Increased Clonal Heterogeneity during Aging, Alongside Critical Changes in Selection Patterns." Blood 144, Supplement 1 (2024): 2671. https://doi.org/10.1182/blood-2024-202289.

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Aging impacts the bone marrow microenvironment by inducing inflammation. We hypothesize that aging increases heritable epigenetic heterogeneity, leading to transcriptome heterogeneity within hematopoietic stem and progenitor cells (HSPC). This resulting heterogenous state, combined with the aged microenvironment-driven selection, shifts the functional capacity of the hematopoietic system, contributing to the functional decline of the hematopoietic system as well as the evolution of diseases such as myelodysplastic syndrome and leukemias. Our research aims to investigate clonal heterogeneity in

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Salehi, Sohrab, Farhia Kabeer, Nicholas Ceglia, et al. "Clonal fitness inferred from time-series modelling of single-cell cancer genomes." Nature 595, no. 7868 (2021): 585–90. http://dx.doi.org/10.1038/s41586-021-03648-3.

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Reusch, T. B. H. "Fitness-consequences of geitonogamous selfing in a clonal marine angiosperm (Zostera marina)." Journal of Evolutionary Biology 14, no. 1 (2001): 129–38. http://dx.doi.org/10.1046/j.1420-9101.2001.00257.x.

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Zhang, Yunchun, Xiaojun Du, Qiaoying Zhang, Xianming Gao, and Zhixian Su. "Fitness analysis of seed and vegetative reproduction of clonal tree Symplocos laurina." Frontiers of Forestry in China 1, no. 2 (2006): 142–49. http://dx.doi.org/10.1007/s11461-006-0014-8.

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