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Rozprawy doktorskie na temat „CNOT3”

Autor: Grafiati
Data publikacji: 14 grudnia 2024
Data aktualizacji: 31 lipca 2025

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1

Martufi, Matteo. "Role of Cnot3 in gene regulation and cell cycle progression." Thesis, Imperial College London, 2014. http://hdl.handle.net/10044/1/24778.

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Gene expression is a process that is tightly regulated by many factors. Different genes are transcribed not only in a cell specific manner but are also differentially expressed at different stages of the cell cycle. Cnot3 is part of the CCR4-NOT deadenylation complex, which is involved in the turnover of mRNAs in the cytoplasm and has also been shown to have roles in regulating transcription and cell proliferation and in maintaining ES cell pluripotency. Previous work demonstrated that Cnot3 interacts directly with Aurora B kinase and is phosphorylated by Aurora B in an in vitro assay. Aurora
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Doidge, Rachel L. "The anti-proliferative activity of BTG/TOB proteins is mediated via the Caf1a (CNOT7)/Caf1b (CNOT8) deadenylase enzymes." Thesis, University of Nottingham, 2013. http://eprints.nottingham.ac.uk/13012/.

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The human BTG/TOB protein family comprises six members (BTG1, BTG2/PC3/Tis21, BTG3/Ana, BTG4/PC3B, TOB1/Tob, and TOB2) that display anti-proliferative activity in a number of cell types. They are characterised by a conserved N-terminal BTG domain that mediates interactions with the Caf1a (CNOT7) and Caf1b (CNOT8) deadenylases. It was unclear whether the anti-proliferative activity of the BTG/TOB proteins was mediated through interactions with Caf1a (CNOT7) and Caf1b (CNOT8). To address this we further characterised the amino acid residues located along the BTG2 and TOB1 interaction surface wit
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Engel, Camille. "Description phénotypique de formes rares de trouble du développement intellectuel et caractérisation des mécanismes moléculaires impliqués." Electronic Thesis or Diss., Bourgogne Franche-Comté, 2024. http://www.theses.fr/2024UBFCE006.

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L’avènement des nouvelles techniques de séquençage a permis d’augmenter de façon considérable le taux diagnostique des troubles du développement intellectuel (TDI) et plus de 2000 gènes impliqués sont aujourd’hui connus. Malgré ces progrès considérables, l’interprétation des variants identifiés par les techniques de séquençage reste parfois difficile et l’histoire naturelle des TDI nouvellement décrits est souvent méconnue. Notre travail a consisté à étudier quatre formes de TDI rares de modes de transmissionvariés sur les plans clinique et génétique afin de mieux comprendre ces affections et
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McFleder, Rhonda L. "Regulation of Local Translation, Synaptic Plasticity, and Cognitive Function by CNOT7." eScholarship@UMMS, 2017. https://escholarship.umassmed.edu/gsbs_diss/915.

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Local translation of mRNAs in dendrites is vital for synaptic plasticity and learning and memory. Tight regulation of this translation is key to preventing neurological disorders resulting from aberrant local translation. Here we find that CNOT7, the major deadenylase in eukaryotic cells, takes on the distinct role of regulating local translation in the hippocampus. Depletion of CNOT7 from cultured neurons affects the poly(A) state, localization, and translation of dendritic mRNAs while having little effect on the global neuronal mRNA population. Following synaptic activity, CNOT7 is rapidly d
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Oliveira, Maria do Socorro Ribeiro de. "Contribuições para comunicação e computação quânticas: análise do PMD e PDL em um sistema de DQC, geração de um estado entrelaçado de quatro modos e uma porta CNOT para qubits de estados coerentes." reponame:Repositório Institucional da UFC, 2013. http://www.repositorio.ufc.br/handle/riufc/10869.

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OLIVEIRA. M. S. R. Contribuições para comunicação e computação quânticas: análise do PMD e PDL em um sistema de DQC, geração de um estado entrelaçado de quatro modos e uma porta CNOT para qubits de estados coerentes. 2013. 60 f. Dissertação (Mestrado em Engenharia de Teleinformática) - Centro de Tecnologia, Universidade Federal do Ceará, Fortaleza, 2013.<br>Submitted by Marlene Sousa (mmarlene@ufc.br) on 2015-02-27T16:34:03Z No. of bitstreams: 1 2013_dis_msroliveira.pdf: 1514414 bytes, checksum: a6c9d9ebe5e73e7933bbb4f387ec9e14 (MD5)<br>Approved for entry into archive by Marlene Sousa(mmarl
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6

Goubault, de Brugière Timothée. "Methods for optimizing the synthesis of quantum circuits Quantum CNOT Circuits Synthesis for NISQ Architectures Using the Syndrome Decoding Problem Quantum circuits synthesis using Householder transformations Synthesizing quantum circuits via numerical optimization Reuse method for quantum circuit synthesis." Thesis, université Paris-Saclay, 2020. http://www.theses.fr/2020UPASG018.

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Pour exécuter un algorithme abstrait sur un ordinateur quantique il faut compiler l'algorithme en une séquence d'instructions bas niveau exécutables par le processeur. L'étape de compilation est cruciale car elle détermine la quantité de ressources nécessaire pour l'exécution d'un algorithme ; par conséquent elle se doit d'être optimisée. Dans cette thèse nous nous intéressons à une brique de la compilation~: la synthèse de circuits quantiques à partir d'une spécification abstraite d'un opérateur. Dans un premier temps nous étudions le cas où la matrice unitaire d'un opérateur quantique nous e
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7

Pasquini, Michael. "Computer quantistici a ioni intrappolati." Bachelor's thesis, Alma Mater Studiorum - Università di Bologna, 2021. http://amslaurea.unibo.it/24678/.

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L'obiettivo di questo elaborato è di dare una descrizione generale del funzionamento di un computer quantistico a ioni intrappolati, dal confinamento degli ioni in trappole unidimensionali fino all’implementazione delle porte logiche. Partendo dalla descrizione della trappola ionica di Paul che confina gli ioni tramite un potenziale di tipo armonico, si è poi descritto in che modo è possibile modificare lo stato interno degli ioni tramite l’interazione con il campo elettromagnetico generato da un laser esterno Si è esaminato nel dettaglio quali sono le principali tipologie di gate a sin
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8

Tsai, Dung-Bang, and 蔡東邦. "Optimal Control of CNOT gate." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/17370157583852447562.

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碩士<br>國立臺灣大學<br>物理研究所<br>96<br>We investigate how pulse-sequences and operation times of elementary quantum gates can be optimized for silicon-based donor electron spin quantum computer architecture, complementary to the original Kane''s nuclear spin proposal. This gate-sequence-optimal or time-optimal quantum gate control in a quantum circuit is in addition to the more conventional concept of optimality in terms of the number of elementary gates needed in a quantum transformation. The optimal control method we use is the so-called gradient ascent pulse engineering (GRAPE) scheme. We focus on
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Tsai, Dung-Bang. "Optimal Control of CNOT gate." 2008. http://www.cetd.com.tw/ec/thesisdetail.aspx?etdun=U0001-1507200819593900.

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Lin, Yu-Chen, and 林育楨. "The Role of CNOT4 E3 Ubiquitin ligase in Influenza A virus replication." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/78341434155778519053.

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碩士<br>國立陽明大學<br>生命科學系暨基因體科學研究所<br>102<br>Abstract Influenza A virus (IAV) is an enveloped RNA virus. Its genome consists of eight single-stranded negative-sense RNAs that encode 12 viral proteins. Each viral RNA segment is packaged with viral nucleoprotein (NP) and RNA-dependent RNA polymerase complex (PB1, PB2 and PA) to form viral ribonucleoprotein (vRNP) complexes. Our previous report showed that NP is a mono-ubiquitinated protein and can be specifically deubiquitinated by cellular deubiquitinase USP11. Ubiquitination of NP could alter the interaction of NP with viral RNA, and USP11 can cle
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11

Yang, Tsun-Yi, and 楊存毅. "Optimal Control of CNOT Gate Operation with Leakagestates and Non-Markovian Environments." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/41258403533969586769.

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碩士<br>國立臺灣大學<br>應用物理所<br>101<br>When building a quantum computer, high precision gate operations are needed. In particular, the controlled-not (CNOT) operation regarded as a crucial universal two-qubit gate is a very important quantum gate to implement. However, real world contains a lot of problems and causes the difference between experimental results and theoretical simulations. In this thesis, we investigate CNOT gate operation using quantum optimal control theory for superconducting charge qubit system taking into account the effects of leakage states and a non-Markovian environment. Firs
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12

Eagleton, Navada Lorraine. "Novel Functions for the Pregnane X Receptor include Regulation of mRNA Turnover and Involvement in Colon Cancer Progression." Thesis, 2010. http://hdl.handle.net/1969.1/ETD-TAMU-2010-08-8029.

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To understand the mechanisms of transcriptional regulation of PXR, we performed yeast two-hybrid screenings to search for PXR-interacting proteins in a human liver cDNA library using the PXR ligand binding domain as the bait. More than one million independent clones were screened. One positive clone was a partial cDNA of CNOT2 (amino acid 183-540). CNOT2 is a component of CCR4-NOT that is a multi-subunit protein complex highly conserved from yeast to humans. Using a mammalian two-hybrid system in CV-1 cells and GST-pull down assays, we confirmed the direct interaction between PXR and CNOT2 and
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13

Brion, E., D. Comparat, and Gil Harel. "Implementation of a CNOT gate in two cold Rydberg atoms by the nonholonomic control technique." 2006. http://hdl.handle.net/10454/3493.

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No<br>We present a demonstrative application of the nonholonomic control method to a real physical system composed of two cold Cesium atoms. In particular, we show how to implement a CNOT quantum gate in this system by means of a controlled Stark field.
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14

Xu, Jing-Yu, and 許景喻. "Sampling-based Optimal Control Method for CNOT Gates of Donor Electron Spin qubits in Silicon." Thesis, 2019. http://ndltd.ncl.edu.tw/handle/zy7g4k.

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碩士<br>國立臺灣大學<br>物理學研究所<br>107<br>Every realistic quantum computer inevitably suffers from decoherence and noise, resulting in errors. Hence, for quantum computing to be viable, delving into the errors for quantum systems and looking for a method, such as the optimal control method for error suppression, has become a critical task. This thesis investigates quantum gate operations for quantum computing based on the electron spins of donors in silicon, which is one of the most promising candidates for spin-based quantum computation as the electron spin qubits have relatively long $T_{1}^{*}$ and
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Dimitrijević, Ivan. "In cammimo verso la totalitá. Esperienza personale come problema filosofico nel pensiero di Nietzsche, Benn, Warburg e Biral." Doctoral thesis, 2013. http://depotuw.ceon.pl/handle/item/243.

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Główna teza dysertacji zatytułowanej In cammino verso la totalità. Esperienza personale come problema filosofico nel pensiero di Nietzsche, Benn, Warburg e Biral, zakłada, że myśl Nietzschego, Benna, Warburga i Birala skierowana jest wobec całości. Nietzsche, Benn, Warburg i Biral deklinują całość na własny sposób: według Nietzschego całość zakłada nobilitację i udoskonalenie człowieka pojmowanego jako ciało i duch, a to uszlachetnienie wymaga totalnego przewartościowania kultury, nowożytnych moralnych, politycznych i religijnych wartości – człowiek musi stać się silniejszy; zdaniem Benna cało
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Cieplak-Rotowska, Maja. "Biophysical and molecular biology studies of proteins involved in gene silencing." Doctoral thesis, 2017. https://depotuw.ceon.pl/handle/item/2368.

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This thesis provides biophysical bases of the interactions between two proteins involved in microRNA (miRNA)-mediated silencing: CNOT1 and the silencing domain of GW182. The regulation of gene expression at the post-transcriptional level involves the crucial CCR4-NOT deadenylase complex, which deadenylates mRNA, and can also inhibit translation in an independent fashion. In miRNA-mediated silencing, the CCR4-NOT complex is brought into the vicinity of the target mRNA by the successive actions of the miRNA, the Argonaute protein and finally, the GW182 protein, which interacts directly with CCR4
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Getka-Kenig, Mikołaj. "Pomniki w Księstwie Warszawskim, Królestwie Polskim oraz Wolnym Mieście Krakowie w latach 1807-1830: komemoracja wizualno-przestrzenna a problem zasługi we "wskrzeszonej" wspólnocie narodowej." Doctoral thesis, 2015.

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Niniejsza rozprawa dotyczy publicznych przedsięwzięć pomnikowych w Księstwie Warszawskim, Królestwie Polskim oraz Wolnym Mieście Krakowie w latach 1807-1830, a więc w tych politycznych bytach, które powszechnie uznawano wówczas za "wskrzeszoną" Polskę (po rozbiorach Rzeczypospolitej Obojga Narodów pod koniec XVIII wieku). Jest to interdyscyplinarne studium łączące metodologię historii kultury z metodami historycystycznego podejścia do sztuki i architektury, skupiające się na problemie ideologicznego i politycznego ugruntowania pomnikowych przedsięwzięć komemoracyjnych dotyczących wybitnych jed
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