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Rozprawy doktorskie na temat „CNSO”

Autor: Grafiati

Data publikacji: 3 czerwca 2025

Data aktualizacji: 31 lipca 2025

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1

Esparza, Christine, Chiho Griffith, and William Martin. "Commander Naval Surface, U.S. Pacific Fleet (CNSP) and Commander Naval Surface, U.S. Atlantic Fleet (CNSL) Travel Support Services Analysis and Recommendations." Thesis, Monterey, California. Naval Postgraduate School, 2007. http://hdl.handle.net/10945/7072.

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Kotter, Mark Reinhard. "Macrophages and CNS remyelination." Thesis, University of Cambridge, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.614264.

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Penderis, Jacques. "Neuregulins and CNS remyelination." Thesis, University of Cambridge, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.620066.

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Birzniece, Vita. "Neuroactive steroids and rat CNS." Doctoral thesis, Umeå : Univ, 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-296.

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Fancy, Stephen Philip James. "Transcriptional control of CNS remyelination." Thesis, University of Cambridge, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.613013.

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Rogers, Madolyn Bowman. "Control of CNS neuronal survival /." May be available electronically:, 2007. http://proquest.umi.com/login?COPT=REJTPTU1MTUmSU5UPTAmVkVSPTI=&clientId=12498.

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Ribeiro, Viviane Gomes Pereira. "Obtaining and characterization of magnetic nanosystems derived of CNSL." Universidade Federal do CearÃ, 2013. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=10628.

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CoordenaÃÃo de AperfeiÃoamento de Pessoal de NÃvel Superior<br>Nanotechnology has received great prominence in recent years due to the versatility of new materials and its applications at the various sectors of society. The functionalized magnetic nanoparticles have been the focus of intense research because of the ability to use on different systems, with emphasis on the catalytic processes of environmental decontamination. In particular, we have seen a growing demand for hybrid catalysts capable of utilizing sunlight, constructed from TiO2 particles by photosensitised dyes. Thus, this study

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Svensén, Sofia. "ADHD Läkemedel : Påverkar föräldrars utbildningsnivå medicinering av barn med ADHD?" Thesis, Örebro universitet, Institutionen för juridik, psykologi och socialt arbete, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-43544.

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Studiens syfte var dels att undersöka om det fanns skillnader iförskrivning av centralstimulantia hos barn som kunde kopplas tillföräldrarnas utbildningsnivå och dels att undersöka om det fannsskillnader i förskrivning av centralstimulantia vid nydiagnosticeradADHD som kunde kopplas till föräldrarnas utbildningsnivå. Uppgifterom studiepopulationen hämtades som aggregerad data frånläkemedelsregistret, patientregistret och utbildningsregistret.Deltagarantal för första forskningsfrågan var 37959 personer, varav25385 pojkar och 12574 flickor. Den andra forskningsfråganomfattade 9443 personer varav

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Nordström, Ulrika. "Early Rostrocaudal Patterning of the CNS." Doctoral thesis, Umeå universitet, Molekylärbiologi (Teknat- och Medfak), 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-614.

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The transformation of an initially uniform population of epiblast cells into an intricately complex central nervous system (CNS) is one of the most fascinating processes during embryonic development. Presumptive neural cells are initially specified as cells of forebrain character. Studies in various vertebrates have indicated that cells of more caudal neural character, that will generate the brain stem and spinal cord, are generated through the reprogramming of these initial rostral cells. The initial regionalization of these neural progenitor cells is central to all further diversification of

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Nordström, Ulrika. "Early rostrocaudal patterning of the CNS /." Umeå : Univ, 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-614.

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Karlström, Helena. "Notch receptor processing and CNS disease /." Stockholm : [Karolinska institutets bibl.], 2002. http://diss.kib.ki.se/2002/91-7349-300-7/.

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12

Baker, B. J. "Vascularisation of grafts to the CNS." Thesis, University of Oxford, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.236280.

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13

Rah, Berend. "A rat assay for CNS repair." Thesis, Open University, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.441158.

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Karda, Rajvinder. "Gene transfer to the neonatal CNS." Thesis, Imperial College London, 2016. http://hdl.handle.net/10044/1/43158.

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A novel technology for the generation of light emitting somatic transgenic animals has been developed using lentiviral vectors where luciferase expression is transcriptionally regulated by tandem, synthetic, transcription factor binding elements. This allows signalling pathways in diseased organs to be monitored continually and consciously and in a non-invasive manner. I was able to confirm my hypothesis that long term somatic transgenesis could be achieved within the CNS after a single neonatal intracranial injection of the biosensors. No signs of activated microglia or astrogliosis from the

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15

McMurran, Christopher Edward. "CNS remyelination and the gut microbiota." Thesis, University of Cambridge, 2018. https://www.repository.cam.ac.uk/handle/1810/277088.

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Remyelination describes the regeneration of myelin sheaths, and is considered one of the most promising strategies for improving the prognosis of demyelinating diseases such as multiple sclerosis. Data from animal models and human studies have shown that remyelination can occur extensively in the central nervous system (CNS), leading to functional recovery and axonal protection. However, remyelination does not always proceed to completion, and its failure is associated with progressive neurological disability. Thus, there is clinical need for interventions that can optimise the conditions for

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16

PELASSA, SIMONE. "Signalling from astrocyte processes in CNS." Doctoral thesis, Università degli studi di Genova, 2021. http://hdl.handle.net/11567/1043545.

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The role of astrocytes in the Central Nervous System (CNS) has been increasingly recognized in the last decades. Astrocytes, indeed, not only support neurons but also play a key role in signal transmission in CNS releasing gliotransmitters as glutamate and participating to the tripartite synpases. Here, astrocytes function in signal transmission was modeled using ex-vivo models purified from adult rat brain, named gliosomes. Using the perfusion technique, release from gliosomes was tested in three different contexts: - glutamate release associated to receptor-receptor interactions, - exoso

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17

Шолохова, Світлана Євгенівна, Светлана Евгеньевна Шолохова, Svitlana Yevhenivna Sholokhova, В. М. Псарьов, П. І. Жук та М. М. Гришина. "Ураження ЦНС при паразитарних хворобах". Thesis, Видавництво СумДУ, 2008. http://essuir.sumdu.edu.ua/handle/123456789/14369.

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Конин, Валерий, та Владимир Загоруйко. "Обеспечение точных заходов на посадку методами спутниковой навигации". Thesis, Авіа 2001: Матеріали III Міжнар. наук.–техн. конф."Авіа-2001", 24- 26 квітня 2001 р. - К.: НАУ.– 2001.– C. 7.104 - 7.107, 2001. http://er.nau.edu.ua/handle/NAU/25606.

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Рассмотрены этапы превращения средств спутниковой навигации в единственное средство навигации воздушных судов. Показано, что аэродромные (локальные) контрольно-корректирующие станции обеспечивают решение задачи точных заходов на посадку посредством спутниковой навигации. Проанализировано состоя-ние развития и определены перспективные схемно-конструктивные решения аэродромных контрольно-корректирующих станций. Сформулированы предложения по раз-работке конкурентноспособных контрольно-корректирующих станций.<br>Национальный авиационный университет

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19

Hainzl, Otmar Karl Werner. "Charakterisierung des Cochaperons Cns1 und Funktionsanalyse des molekularen Chaperons Hsp90." München Verl. Dr. Hut, 2008. http://d-nb.info/988229366/04.

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20

Fransson, Moa. "CNS-Targeted Cell Therapy for Multiple Sclerosis." Doctoral thesis, Uppsala universitet, Enheten för klinisk immunologi, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-132364.

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Multiple sclerosis (MS) is an autoimmune disorder of the central nervous system (CNS). In the current thesis, we have preformed an immunological investigation of patients with MS and developed an immunosuppressive cell therapy that could be beneficial for these patients. MS has been considered to be driven by T helper type1 (Th1) lymphocytes but new data indicate the involvement of Th17 responses. T cells from patients with MS that were evaluated for immunological status secreted both interferon-γ and interleukin-17 upon stimulation. However, T cells from patients with MS in remission, in cont

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Wosik, Karolina. "Impact of injury mediators on CNS glia." Thesis, McGill University, 2004. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=85105.

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Multiple Sclerosis (MS) is an inflammatory disorder of the central nervous system (CNS). It is characterized by the infiltration of immune cells into the brain, leading to myelin destruction and the demise of oligodendrocytes (OLs), the myelinating cells of the CNS. The mechanisms of tissue destruction are still being elucidated. We have looked at the effects of two putative injury mediators on resident CNS glia. Firstly, we investigated the functional consequences of signaling via death receptors Fas, DR4 and DR5 and their ligands Fas ligand (FasL) and tumor necrosis factor related apo

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22

Dev, Kumlesh Kumar. "Regulation of AMPA receptors in rat CNS." Thesis, University of Bristol, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.337228.

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Shinawi, Thoraia M. "Genetic and epigenetic changes in CNS cancers." Thesis, University of Birmingham, 2015. http://etheses.bham.ac.uk//id/eprint/6166/.

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Cancer is a result of multiple genetic and epigenetic alterations that are acquired during tumour formation and progression. The development of cost-effective high-throughput technologies has positively contributed to the field of cancer research to identify cancerassociated genes, in addition to diagnostic and prognostic markers. Using the most recent Illumina Infinium HumanMethyaltion450K BeadChip, this work has identified 23 genes that were significantly and differentially hypermethylated in short-term survivor (STS) glioblastoma patients and showed an association with poor prognosis. Inter

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Coutts, David John Charles. "Peripheral type remyelination of the demyelinated CNS." Thesis, University of Cambridge, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.610087.

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Kaltschmidt, Julia Anna. "Generating asymmetry in the developing Drosophila CNS." Thesis, University of Cambridge, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.621281.

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Poul, Ondřej. "Analýza rizik kontejnerových nůžek řady CNS-K." Master's thesis, Vysoké učení technické v Brně. Fakulta strojního inženýrství, 2011. http://www.nusl.cz/ntk/nusl-229923.

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This thesis deals with the safety of an enginery, namely with container shears of Žďas company in Žďár nad Sázavou. Initial familiarization with the machine was followed by the proposition of a relevant block diagram and the definition of the usage limits, in aim to analyse the risks related to the use of such an enginery

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27

Kyles, Andrew Edward. "Evaluation of the spinal and supraspinal roles of antinociceptive drugs in sheep." Thesis, University of Bristol, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.389998.

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Katte, Timothy Aaron. "The Design and Synthesis of Small Non-Peptide Oxytocin Receptor Ligands." Thesis, University of Sydney, 2020. https://hdl.handle.net/2123/23740.

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This thesis describes the design, synthesis and pharmacological evaluation of non-peptide based oxytocin receptor ligands for the treatment of mental disorders. The current work describes the investigation of pharmacophores for the oxytocin receptor based on scaffolds such as diazepines and elaborate carbazole derivatives as head groups. These cores were modified by altering heteroatoms, ring size and shape and adding a pendant cyclic amide. The pendant cyclic amide has been found to be a requisite for observing oxytocin receptor activation and changes to the core were made to synthesise a li

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Guo, Ningning. "GSH : a new candidate neuropeptide in the CNS." Thesis, University of British Columbia, 1991. http://hdl.handle.net/2429/29856.

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The physiological significance of glutathione (GSH) in the mammalian central nervous system is still uncertain, although some evidence has indicated that GSH may play an important role in the CNS. To address the question of whether GSH may be a candidate for a neuropeptide in the CNS, one step is to establish that GSH receptors are present. In the present study, biotinyl-GSH was synthesized and purified to detect the GSH receptor in the CNS. Histochemical experiments showed that GSH binding sites appeared on the white matter ( such as cingulum, dorsal hippocampal commissure, cerebral peduncl

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Aguilar, Salegio Ernest Antonio, and Ernest Aguilar@flinders edu au. "Pre-Conditioned Lesion: Inflammatory Effects on CNS Regeneration." Flinders University. School of Medicine, 2009. http://catalogue.flinders.edu.au./local/adt/public/adt-SFU20100621.024316.

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In the adult central nervous system (CNS) several factors are implicated in the failure of neurons to regenerate after spinal cord injury (SCI). However, this reduced ability of injured CNS neurons to regenerate can be improved by under certain conditions. For instance, in adult dorsal root ganglion (DRG) neurons, injury to its peripheral branch (unilateral conditioning lesion) prior to injury of its central DRG branch (dorsal column cut) enhances the intrinsic capability of some but not all CNS afferent neurons to regenerate. The exact mechanism mediating this type of response is not known. H

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Lothian, Carina. "Nestin regulation in the embryonic and adult CNS /." Stockholm : [Karolinska institutets bibl.], 2001. http://diss.kib.ki.se/2001/91-7349-057-1/.

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Shen, Jun. "Factors influencing topotecan CNS penetration in mouse models." View the abstract Download the full-text PDF version, 2008. http://etd.utmem.edu/ABSTRACTS/2008-026-Shen-Index.html.

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Thesis (Ph.D.)--University of Tennessee Health Science Center, 2008.<br>Title from title page screen (viewed on Sept. 17, 2008). Research advisor: Clinton Stewart, Pharm.D. Document formatted into pages (xiii, 105 p. : ill.). Vita. Abstract. Includes bibliographical references (p. 80-102).

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Tai, Chao. "Cholinergic modulation of ion channels in the CNS." Thesis, University of British Columbia, 2009. http://hdl.handle.net/2429/24215.

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The cholinergic system is one of the most important modulatory neurotransmitter systems in the CNS. In this dissertation, I report novel cholinergic modulations of three Ca²⁺ permaable ion channels, including R-type voltage-gated calcium channels (VGCCs), TRPC5 channels and NMDA receptors, in hippocampal CA1 pyramidal neurons and the potential functional roles of these modulations in both physiological and pathophysiological conditions. I first studied the “toxin-resistant” R-type VGCCs, and found that muscarinic activation specifically enhances R-type, but does not affect T-type, Ca²⁺ current

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Andersson, Peter-Brian. "Leukocyte recruitment and microglial activation in CNS inflammation." Thesis, University of Oxford, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.293391.

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Lalatsa, Aikaterini. "Carbohydrate nanoparticles for peptide delivery to the CNS." Thesis, University of London, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.509308.

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Rigby, Anne. "Targeting the CNS for repair : development of immunotrophs." Thesis, Queen Mary, University of London, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.511343.

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Meister, Sabrina [Verfasser]. "Blood-CNS barriers in neurodegenerative diseases / Sabrina Meister." Mainz : Universitätsbibliothek Mainz, 2015. http://d-nb.info/107232167X/34.

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Caprio, Joseph L., and Daniel Leszczynski. "A Preliminary Investigation into CNO Availability Schedule Overruns." Thesis, Monterey, California. Naval Postgraduate School, 2012. http://hdl.handle.net/10945/7315.

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A naval vessels availability is a scheduled period of time, normally conducted in a shipyard, to perform maintenance on and modernization of the vessel and its systems. The four public naval shipyards are continually challenged to complete depot-level, CNO availabilities on schedule. A naval vessels late return to the fleet results in the decrease in operational readiness due to the reduced number of operational days available for these vessels. Subject-matter experts hypothesize that factors such as inadequate planning for resources, quantity of overtime, and quantity of work stoppages experi

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Zhu, Min. "CNS active principles from selected Chinese medicinal plants." Thesis, University College London (University of London), 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.339881.

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Goncharevich, Alexander. "Epigenetic control of Wnt signalling in CNS remyelination." Thesis, University of Cambridge, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.648183.

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Gnanapavan, S. "Putative biomarkers of neuro-restoration in the CNS." Thesis, University College London (University of London), 2013. http://discovery.ucl.ac.uk/1397881/.

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The aim of this work was to investigate putative biomarkers of neuronal plasticity and repair in the central nervous system. The effects of different disease processes, such as inflammation, demyelination and neurodegeneration were explored. We developed and validated ELISA-based assays for the quantification of neural cell adhesion molecule (NCAM) and growth-associated protein (GAP)-43, two known facilitators of neuronal outgrowth in the nervous system. NCAM isoforms in biological samples were characterised using mass spectrometry. Soluble NCAM was measured in in-vitro and in-vivo models of i

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Ekuase, Philip, and Mhando Catherine Samwel. "Neurospecific enolase - early diagnostical marker of CNS damage." Thesis, Sumy State University, 2015. http://essuir.sumdu.edu.ua/handle/123456789/41257.

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Ignatius, Arokia Doss Prenitha Mercy. "Understanding progressive CNS autoimmunity using transgenic mouse models." Doctoral thesis, Université Laval, 2019. http://hdl.handle.net/20.500.11794/36448.

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La sclérose en plaques (SP) est une maladie auto-immune chronique du système nerveux central (SNC) caractérisée par une neurodégénérescence et une invalidité croissante avec le temps. Au Canada, plus de 100 000 personnes sont atteintes de SP. Plusieurs facteurs peuvent contribuer à l’aggravation de la maladie, mais la cause exacte n’est toujours pas connue. Il est largement admis que les lymphocytes T et B franchissent la barrière hémato-encéphalique et invoquent une attaque inflammatoire contre la myéline du SNC. Le rôle des cellules T et B dans l'auto-immunité du SNC peut être étudié à l'aid

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Smith, Dawn L. "CNS delivery of antisense oligodeoxynucleotides using biodegradable microspheres." Thesis, Aston University, 2000. http://publications.aston.ac.uk/10991/.

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Antisense oligodeoxynucleotides can selectively inhibit gene expression provided they are delivered to their target site successfully for a sufficient duration. Biodegradable microspheres have previously been developed for the potential systemic delivery of antisense oligodeoxynucleotides and offer an excellent strategy for central administration of antisense oligodeoxynucleotides, providing a sustained-release delivery system. Biodegradable microspheres were formulated to entrap antisense oligodeoxynucleotides for stereotaxic implantation into site-specific regions of the rat brain. Release p

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Kishimoto, Wataru. "Expression of Tim-1 in primary CNS lymphoma." 京都大学 (Kyoto University), 2017. http://hdl.handle.net/2433/225485.

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Nezbeda, Filip. "Hydraulický pohon kontejnerových nůžek CNS 730/190 MTC." Master's thesis, Vysoké učení technické v Brně. Fakulta strojního inženýrství, 2012. http://www.nusl.cz/ntk/nusl-230384.

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This work includes design of the drive hydraulic shears. The objective is to replace diesel-engine for electric motor. There is a description of the machine and its technological shearing process, types of hydraulic drives and their applications. The work includes the design, description and calculation of hydraulic power unit with an electric motor in two versions. Then there is evaluation of alternatives and select one to which they are processed further structural elements.

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Eusebi, Silvia. "Creatine supplementation and neural plasticity in CNS development." Doctoral thesis, Urbino, 2018. http://hdl.handle.net/11576/2663607.

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Rinaldo, Carina, and Karin Johansson. "Postoperativ smärtbehandling till barn med hjärntumör." Thesis, Uppsala universitet, Institutionen för folkhälso- och vårdvetenskap, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-126841.

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Smärta i samband med intrakraniell kirurgi liknar smärta i samband med all annan form av kirurgi. Syftet var att granska hur barn med hjärntumör smärtbedömts och smärtbehandlats postoperativt efter tumörkirurgi. Metod: Totalt har journaler för 40 barn (20 barn på Akademiska barnsjukhuset i Uppsala och 20 barn på Astrid Lindgrens barnsjukhus vid Karolinska sjukhuset, Stockholm) som opererats för tumörer i hjärnan granskats, avseende smärtbedömning, användandet av smärtskalor, farmakologiska och ickefarmakologisk smärtbehandling de tre första postoperativa dygnen. Resultat: Studien visade att sm

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Bera, Katarzyna D. "Autoantibodies to N-methyl D-aspartate receptors in autoimmune encephalitis." Thesis, University of Oxford, 2011. http://ora.ox.ac.uk/objects/uuid:6bbda982-ab5c-4982-b23a-0478c689869c.

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N-methyl-D-aspartate receptor (NMDAR) antibody encephalitis is a recently described autoimmune encephalopathy defined by the presence of serum antibodies that bind NMDARs (NMDAR-Abs). NMDAR-Ab encephalitis is a severe, but treatmentresponsive encephalitis with subacute onset. It can be associated with tumours and affects mainly young adults. Patients present with cognitive dysfunction, seizures, psychiatric and sleep disorders and most develop dyskinesias, autonomic instability and reduced consciousness. To explore further the NMDAR-Abs and their potential pathogenicity, a series of in vitro i

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Jerina, Helen. "Studies on chronic pain mechanisms in the central nervous system." Thesis, University of Bath, 2011. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.557799.

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Chronic pain is one of the most significant medical and scientific challenges in western society today. As well as the emotional and physical effects on the individual it proves to be a significant financial burden to society. Studies have shown that chronic pain leads to central sensitisation that is partially regulated by release of proinflammatory molecules within the CNS. Most work has concentrated on the role of the spinal cord and little is known about changes in supraspinal regions. The CFA footpad model was used to investigate the expression of inflammatory mediators in the brain in pe

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