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Artykuły w czasopismach na temat „CNSO”

Autor: Grafiati

Data publikacji: 3 czerwca 2025

Data aktualizacji: 31 lipca 2025

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1

Smolczyk, Tyler J., and Timothy D. Lash. "Alphabet soup within a porphyrinoid cavity: synthesis of heterocarbaporphyrins with CNNO, CNOO, CNSO and CNSeO Cores from an oxacarbatripyrrin." Chemical Communications 54, no. 65 (2018): 9003–6. http://dx.doi.org/10.1039/c8cc04976a.

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Gossai, Nathan, Stuart S. Winter, Meenakshi Devidas, et al. "Prognostic Impact of CNS-2 status in T-ALL: A report from the Children’s Oncology Group." Journal of Clinical Oncology 39, no. 15_suppl (2021): 10003. http://dx.doi.org/10.1200/jco.2021.39.15_suppl.10003.

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10003 Background: In B-acute lymphoblastic leukemia (B-ALL), CNS2 was associated with inferior 5-year (yr) event-free and overall survival (EFS/OS) in recent trials. Here, we report the impact of CNS2 in T-ALL on AALL0434 and AALL1231, recently completed consecutive randomized phase 3 trials for children and young adults with T-ALL and T Lymphoblastic Lymphoma. This report is limited to T-ALL. Both trials used augmented Berlin Frankfurt Münster regimens. AALL0434 compared Capizzi escalating methotrexate+pegaspargase (C-MTX) vs High Dose MTX (HDMTX) +/- six nelarabine (Nel) courses; outcomes im

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Kumar, Ashok, K. Rajan, M. Rajaram Naraynan, and K. R. Senthil Kumar. "Performance and Emission Characteristics of a Di Diesel Engine Fuelled with Cashew Nut Shell Oil (CNSO)-Diesel Blends with Diethyl Ether as Additive." Applied Mechanics and Materials 787 (August 2015): 746–50. http://dx.doi.org/10.4028/www.scientific.net/amm.787.746.

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Cashew nut shell oil (CNSO) is potential alternative fuel for diesel engine. Its drawback is incomplete combustion and low brake thermal efficiency (BTE) due to high viscosity. To overcome this problem the CNSO was blended with diethyl ether (DEE) which is less viscous and burns easily. The influence of blends on CO, NOx and smoke emission is investigated by emission tests. The fuel containing 20% CNSO and 80% diesel fuel (B20), 95% B20 and 5% DEE by volume (B20D5), 90% B20 and 10%DEE by volume (B20D10) 85% and B20 and 15% DEE by volume (B20D15) are tested. Initially the experiment was conduct

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Johnston, Donna, Jeffrey E. Rubnitz, Todd A. Alonzo, et al. "An Analysis of CNS2 Patients with AML: Do They Require Additional Intrathecal Therapy? a Report from Children’s Oncology Group Protocols AAML0531 and 03P1 and St Jude Children’s Research Hospital Protocol AML02." Blood 124, no. 21 (2014): 277. http://dx.doi.org/10.1182/blood.v124.21.277.277.

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Abstract Introduction: Pediatric patients with acute myeloid leukemia (AML) require central nervous system (CNS) directed chemotherapy to minimize CNS relapse. Patients with AML who have CNS disease at diagnosis, defined as >5 white blood cells (WBC) with positive blast in cytospin, require more intensive CNS directed therapy to clear CNS disease and prevent CNS relapse. Those with <5 WBC but with a positive cytospin are designated as CNS2 disease. Those without any blast (negative cytospin) are designated as CNS1. The need for extra CNS therapy for CNS2 patients varies among treatment p

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Bürger, Britta, Martin Zimmermann, Georg Mann, et al. "Diagnostic Cerebrospinal Fluid Examination in Children With Acute Lymphoblastic Leukemia: Significance of Low Leukocyte Counts With Blasts or Traumatic Lumbar Puncture." Journal of Clinical Oncology 21, no. 2 (2003): 184–88. http://dx.doi.org/10.1200/jco.2003.04.096.

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Purpose: To determine the significance of leukemic blasts or traumatic lumbar puncture (TLP) in diagnostic CSF of children enrolled in the Berlin-Frankfurt-Münster (BFM) Acute Lymphoblastic Leukemia–BFM-95 trial. Patients and Methods: A total of 2,021 patients were retrospectively evaluated according to initial central nervous system (CNS) status. Patients were classified as follows: CNS1 (CNS negative, n = 1,605), CNS2 (≤ 5 WBC/μL CSF with blasts, n = 103), CNS3 (CNS positive, n = 58), TLP+ (TLP with blasts, n = 135), or TLP− (TLP without blasts, n = 111). Patients with CNS2 and TLP+ status w

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6

Kabulova, I. V., and L. V. Tsallagova. "The role of new medical technologies in the relief of chronic pelvic pain and the rehabilitation of reproductive function." CARDIOMETRY, no. 23 (August 20, 2022): 58–63. http://dx.doi.org/10.18137/cardiometry.2022.23.5863.

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The low efficacy of ongoing conventional therapy and a significant decrease in the quality of life in patients with reconstructive plastic surgery (RPO) on the pelvic organs (PO) due to tubal-peritoneal infertility (TPI) and chronic nonspecific salpingo-oophoritis (CNSO) requires searching for new, promising methods of non-drug treatment, in particular, taking into account the regional characteristics of the Republic of North Ossetia-Alania and its natural resources. One of the main ways to increase the efficacy and intensify the treatment of this category of patients is the use of natural fac

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7

Winick, Naomi, Meenakshi Devidas, Si Chen, et al. "Impact of Initial CSF Findings on Outcome Among Patients With National Cancer Institute Standard- and High-Risk B-Cell Acute Lymphoblastic Leukemia: A Report From the Children’s Oncology Group." Journal of Clinical Oncology 35, no. 22 (2017): 2527–34. http://dx.doi.org/10.1200/jco.2016.71.4774.

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Purpose To determine the prognostic significance of blasts, and of white and red blood cells, in CSF samples at diagnosis of acute lymphoblastic leukemia (ALL), a uniform CSF and risk group classification schema was incorporated into Children’s Oncology Group B-cell ALL (B-ALL) clinical trials. Methods CSF status was designated as follows: CNS1, no blasts; CNS2a to 2c, < 5 WBCs/μL and blasts with/without ≥ 10 RBCs/μL or ≥ 5 WBCs/μL plus blasts, with WBCs ≥ 5 times the number of RBCs; CNS3a to 3c, ≥ 5 WBCs/μL plus blasts with/without ≥ 10 RBCs/μL or clinical signs of CNS disease. CNS2 status

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8

Sekunowo, O. I., and G. U. Uduh. "Extraction and physicochemical characterization of cashew nut-shell liquid in metal forming." Nigerian Journal of Technological Development 19, no. 2 (2022): 110–15. http://dx.doi.org/10.4314/njtd.v19i2.2.

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ABSTRACT: Effective lubrication during metal working is critical to mitigating undesirable tool wear and poor surface finish of formed components. This paper investigated the physicochemical characteristics of cashew nut-shell-liquid (CNSL) with a view of determining its suitability for the development of an eco-friendly lubricant used in metal forming. The cashew nut shell oil (CNSO) was extracted by soxhlet method and characterised to determine its physicochemical properties including density, free fatty acid (FFA), and viscosity. In addition, the saponification value, iodine value, pH, flas

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9

Broge-Reynen, Kristine, Emily Giever, Aniko Szabo, et al. "CNS Status at Diagnosis Can Identify Acute Myeloid Leukemia Patients with Poor Induction Outcomes." Blood 144, Supplement 1 (2024): 5173. https://doi.org/10.1182/blood-2024-208834.

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Background: The incidence of central nervous system (CNS) involvement in acute myeloid leukemia (AML) is not well known, and the use of routine lumbar punctures (LPs) in these patients (pts) has been widely debated. Clear guidelines for diagnostic LP in newly diagnosed AML pts are lacking, practices vary among experts and institutions, and LPs are not routinely performed in AML pts. Estimates of CNS involvement vary due to differing detection methods, and current AML management may have reduced the frequency of leukemic CNS involvement. Our institution guidelines recommend performing LPs for p

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10

Johnston, Donna L., Todd A. Alonzo, Robert B. Gerbing, et al. "The Effect of Traumatic Diagnostic Lumbar Puncture in De Novo Pediatric Acute Myeloid Leukemia - a Report from the Children's Oncology Group." Blood 128, no. 22 (2016): 4016. http://dx.doi.org/10.1182/blood.v128.22.4016.4016.

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Abstract Background - In many adult protocols for acute myeloid leukemia (AML), the standard of care is to perform a lumbar puncture (LP) at the time of diagnosis only if there are central nervous system (CNS) symptoms present, and if absent, the LP is performed after a period of systemic therapy in order to avoid contamination of the cerebrospinal fluid (CSF) with circulating blasts in the case of a traumatic LP, or is not done at all. This differs from the practice in pediatric AML protocols where LP is performed as part of the diagnostic workup and intrathecal (IT) cytarabine given at the t

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11

Yu, Fengtao, Zhiqiang Wang, Shicong Zhang, et al. "Construction of polymeric carbon nitride and dibenzothiophene dioxide-based intramolecular donor–acceptor conjugated copolymers for photocatalytic H2 evolution." Nanoscale Advances 3, no. 6 (2021): 1699–707. http://dx.doi.org/10.1039/d0na01011a.

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A series of intramolecular g-C<sub>3</sub>N<sub>4</sub>-based donor–acceptor conjugated copolymers have been obtained by copolymerizing urea with 3,7-dihydroxydibenzo[b,d]thiophene 5,5-dioxide (SO). As a result, the AQY of CNSO-20 reached 10.16% at 420 nm.

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12

Zwaan, Christian M., A. J. P. Veerman, Birgit E. M. Van der Linden-Schrever, and Elisabeth van Wering. "Dexamethasone-Based Treatment and the Risk of CNS-Relapse in Acute Lymphoblastic Leukemia: Results from DCOG Protocol ALL-9." Blood 108, no. 11 (2006): 1867. http://dx.doi.org/10.1182/blood.v108.11.1867.1867.

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Abstract Several groups recently reported on the significance of small numbers of blasts (CNS2; WBC ≤5×106/l with morphological blasts) in the cerebrospinal fluid (CSF), as well as on traumatic lumbar puncture (TLP+; >10 eyrthrocytes ×106/l, with blasts). In general, CNS2 does not have poor prognostic significance, whereas TLP+ does. We retrospectively analysed the prognostic influence of CSF involvement in DCOG ALL-9, which was highly dexamathasone (DEX) driven. The induction consisted of 3 drugs with DEX 6 mg/m2, followed by 3 MTX courses 2 g/m2 (4 × 3 gr/m2 for high-risk (HR) patients),

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13

Johnston, Donna L., Todd A. Alonzo, Robert B. Gerbing, Beverly J. Lange, and William G. Woods. "The Presence of Central Nervous System Disease at Diagnosis in Pediatric Acute Myeloid Leukemia Does Not Affect Outcome." Blood 110, no. 11 (2007): 1827. http://dx.doi.org/10.1182/blood.v110.11.1827.1827.

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Abstract Introduction: The presence of disease in the central nervous system (CNS) in pediatric acute myeloid leukemia (AML) is often thought to confer a worse prognosis. This study examined the outcome of children with AML who had CNS disease at diagnosis. Methods: Patients enrolled on Children’s Oncology Group protocols 2891 (N=836)and 2961 (N=901) being treated for de novo AML were classified for the presence of CNS disease at diagnosis as: CNS1 (less than 5 WBC in the CSF with no blasts), CNS2 (less than 5 WBC in the CSF with blasts) or CNS3 (5 or more WBC in the CSF with blasts). CNS dise

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14

te Loo, D. Maroeska W. M., Willem A. Kamps, Anna van der Does-van den Berg, Elisabeth R. van Wering, and Siebold S. N. de Graaf. "Prognostic Significance of Blasts in the Cerebrospinal Fluid Without Pleiocytosis or a Traumatic Lumbar Puncture in Children With Acute Lymphoblastic Leukemia: Experience of the Dutch Childhood Oncology Group." Journal of Clinical Oncology 24, no. 15 (2006): 2332–36. http://dx.doi.org/10.1200/jco.2005.03.9727.

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Purpose To determine the significance of blasts in the CSF without pleiocytosis and a traumatic lumbar puncture in children with acute lymphoblastic leukemia (ALL). Patients and Methods We retrospectively studied a cohort of 526 patients treated in accordance with the virtually identical Dutch protocols ALL-7 and ALL-8. Patients were classified into five groups: CNS1, no blasts in the CSF cytospin; CNS2, blasts present in the cytospin, but leukocytes less than 5/μL; CNS3, blasts present and leukocytes more than 5/μL. Patients with a traumatic lumbar puncture (TLP; > 10 erythrocytes/mL) were

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15

G.V.VN., Sivanjaneyulu*1 &. V.Dhana Raju2. "EXPERIMENTAL STUDIES ON DIESEL ENGINE FULLED WITH CASHEW NUT SHELL OIL AS AN ALTERNATE FUEL." INTERNATIONAL JOURNAL OF ENGINEERING SCIENCES & RESEARCH TECHNOLOGY 6, no. 7 (2017): 433–43. https://doi.org/10.5281/zenodo.828935.

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This paper evaluates the novel use of cashew nut shell oil (CNSO) as an alternative fuel for diesel. Biodiesel is produced free from environment, and different types of vegetable oils and animal fats. It has highly oxygenated, non-toxic, sulfur free.The renewable fuel that can be adoption in diesel engines without any change. Direct injection diesel engine have been experimentally examine with CNSO methyl esters and its blends (C10, C20 and C30) with diesel fuel. Engine performance parameters namely Brake specific fuel consumption, Brake thermal efficiency, combustion and exhaust emissions of

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Zhang, Yibing, Jing PAN, Fan Wu, Zhuojun Ling, and Kai Wang. "Safety and Feasibility of Intrathecal Infusion of CD19 and/or CD22 CAR T Cells in r/r B-ALL Patients with CNSL or High-Risk CNS Relapse." Blood 144, Supplement 1 (2024): 3466. https://doi.org/10.1182/blood-2024-201376.

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The central nervous system (CNS) is a sanctuary for leukemia and approximately 10% of patients have pre-existing CNS infiltration at diagnosis. Conventional central nervous system leukemia (CNSL) therapy included high-dose chemotherapy, intrathecal drugs and cranial radiotherapy. However, challenges remain in CNS relapse after multiple chemotherapy and stem cell transplantation. A novel treatment for relapsed or refractory B-cell acute lymphoblastic leukemia (r/r B-ALL) using CD19 or CD22 chimeric antigen receptor (CAR) T cells has recently shown promising results. Considering CAR T infusion m

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Yang, Xiaomei, Jing Yang, Shuang Huang, et al. "Clinical Features and Therapeutic Evaluation of Central Nervous System Involvement in Pediatric Anaplastic Large Cell Lymphoma." Blood 142, Supplement 1 (2023): 1709. http://dx.doi.org/10.1182/blood-2023-188173.

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Objective：To analyze the clinical features of central nervous system involvement (CNS3) in pediatric anaplastic large cell lymphoma (ALCL) and evaluate the efficacy of CNCL-ALCL-2017 protocol for the treatment of CNS3. Methods：The clinical data of 215 pediatric ALCL patients ≤18 years old enrolled in the Chinese Children's Cancer Group (CNCL) between April 2017 and March 2023 were collected sequentially. All enrolled patients staging and CNS layering were according to the IPNHLSS staging system and treated with CNCL-ALCL-2017 protocol (modified BFM-ALCL99 protocol). The clinical features at di

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Rodriguez, Alyssa, Maximilian Wengyn, My H. Vu, et al. "Impact of Central Nervous System (CNS) Leukemia Status-Based Therapeutic Protocol Change on the Incidence of CNS2 Diagnosis in Pediatric B-Lymphoblastic Acute Leukemia." Blood 142, Supplement 1 (2023): 1457. http://dx.doi.org/10.1182/blood-2023-190743.

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B-lymphoblastic acute leukemia (B-ALL) is the most prevalent cancer among children, and prophylactic central nervous system (CNS) therapy has significantly contributed to high cure rates for the past 50 years. However, relapses in bone marrow and/or CNS continue to pose challenges to achieving cure for all patients, especially in those with high-risk disease. CNS status at diagnosis, defined as CNS1 (no blasts present), CNS2 (blasts with &lt;5 total white blood cells [WBC] per mm 3 in a cerebrospinal fluid [CSF] sample), and CNS3 (blasts with ≥5 total WBC per mm 3 or grossly traumatic), pl

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Johnston, Donna, Todd Alonzo, Robert Gerbing, Beverly Lange, and William G. Woods. "Pediatric Patients with Extramedullary Leukemia Involving the Central Nervous System Have a Superior Outcome." Blood 112, no. 11 (2008): 920. http://dx.doi.org/10.1182/blood.v112.11.920.920.

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Abstract Purpose: Extramedullary leukemia (EML), formally known as chloroma, is discrete collections of leukemia cells outside of the bone marrow. EML is often seen within the central nervous system (CNS) and these are often treated in a similar fashion as leukemia cells within the cerebral spinal fluid (CSF). We previously demonstrated that the presence of leukemia cells within the CSF (CNS leukemia) does not affect overall survival. We sought to determine the outcome of patients with central nervous system EML and compare these patients with those with CNS disease and non CNS EML. Methods: P

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S. Santhanakrishnan, S. Santhanakrishnan, and S. Jose S. Jose. "A Study on Compression Ignition Engine Performance Using Diesel-Cnso-Eea Blend." Global Journal For Research Analysis 3, no. 4 (2012): 68–69. http://dx.doi.org/10.15373/22778160/apr2014/22.

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Dimov, Stojce Ilcev. "Architecture of the regional satellite augmentation system for maritime applications." TELKOMNIKA Telecommunication, Computing, Electronics and Control 18, no. 3 (2020): 1610–20. https://doi.org/10.12928/TELKOMNIKA.v18i3.15641.

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This paper describes architecture of regional satellite augmentation system (RSAS) in the function of the maritime space communications, navigation and surveillance (CNS) and global navigation satellite systems (GNSS) networks for enhanced safety and surveying of oceangoing ships, management and tracking of cargo, security of Mariners onboard commercial and passenger ships, yachts, sea platforms and other types of craft. The RSAS network are designed to improve vessel management and transport operation because of the enormous expansion of the world's merchant fleet. However, this network w

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Romdhini, Mamika Ujianita, Ashraf Al Al-Quran, Faisal Al Al-Sharqi, Hazwani Hashim, and Abdalwali Lutfi. "Unveiling an Innovative Approach to Q-Complex Neutrosophic Soft Rings." International Journal of Neutrosophic Science 22, no. 4 (2023): 29–35. http://dx.doi.org/10.54216/ijns.220402.

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In this paper, our aim is to investigate the algebraic structures within the Q-complex neutrosophic soft model. We introduce two fundamental concepts: the Q-complex neutrosophic soft ring (Q-CNSR) and the Q-complex neutrosophic soft ideal (Q-CNSI). Q-CNSRs combine the properties of Q-complex neutrosophic soft sets (Q-CNSSs) with ring theory, effectively capturing uncertainty and indeterminacy present in ring operations through the incorporation of Q-complex neutrosophic membership values. Additionally, we define Q-CNSIs as subsets of Q-CNSRs that possess distinctive properties and hold signifi

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Seth, Tulika, Kavya Keerthana, Jasmita Dass, Mukul Agarwal, Deepam Pushpam, and Saumyaranjan Mallick. "Kinetics of Blast Clearance in Cerebrospinal Fluid (CSF) Detected on Flow Cytometric Immunophenotyping (FCM), but Negative By Cytopathology in Newly Diagnosed Acute Lymphoblastic Leukemia Patients." Blood 144, Supplement 1 (2024): 4181. https://doi.org/10.1182/blood-2024-210015.

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Background: Flow cytometric immunophenotyping (FCM) detects two-fold higher CSF disease. Limited data on kinetics of CNS disease detected in this manner. Our study aimed to identify and follow course of CSF FCM+ in newly diagnosed ALL. Serial CSF FCM examinations performed to detect and see persistence of blasts. Identify risk factors for CSF involvement any correlation with post-induction measurable residual disease (PI-MRD). Methods: Enrolled 125 patients newly diagnosed treatment naïve ALL patients from April 2022 to December 2023, Ethics approval and informed consent. CNS status assessed C

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Guo, Lin, Tianguo Chen, Xue Chu, et al. "Anatomical and Transcriptome Analyses of Moso Bamboo Culm Neck Growth: Unveiling Key Insights." Plants 12, no. 19 (2023): 3478. http://dx.doi.org/10.3390/plants12193478.

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The Moso bamboo culm neck, connected with the rhizome and the shoot bud, is an important hub for connecting and transporting the aboveground and belowground systems of bamboo for the shoot bud development and rapid growth. Our previous study revealed that the culm neck generally undergoes six different developmental stages (CNS1–CNS6), according to the primary thickening growth of the underground shoot bud. However, the molecular mechanism of the culm neck development remains unknown. The present study focused on the developmental process of the CNS3–CNS5 stages, representing the early, middle

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Hicks, Chindo, Jitsuda Sitthi-Amorn, Jessica Douglas, et al. "Molecular Analysis of Central Nervous System Disease Spectrum in Childhood Acute Lymphoblastic Leukemia." Clinical Medicine Insights: Oncology 10 (January 2016): CMO.S18180. http://dx.doi.org/10.4137/cmo.s18180.

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Treatment of the central nervous system (CNS) is an essential therapeutic component in childhood acute lymphoblastic leukemia (ALL). The goal of this study was to identify molecular signatures distinguishing patients with CNS disease from those without the disease in pediatric patients with ALL. We analyzed gene expression data from 207 pediatric patients with ALL. Patients without CNS were classified as CNS1, while those with mild and advanced CNS disease were classified as CNS2 and CNS3, respectively. We compared gene expression levels among the three disease classes. We identified gene sign

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Di Fazio, Ilaria, Lena Behrmann, Valerie de Haas, et al. "Cerebrospinal Fluid Flow Cytometry Improves Patient Stratification in Central Nervous System Acute Lymphoblastic Leukaemia but Requires Careful Standardization: Results from the ALLTogether1 CSF-FLOW Sub-Study." Blood 144, Supplement 1 (2024): 2831. https://doi.org/10.1182/blood-2024-203138.

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The central nervous system (CNS) is an important sanctuary site for acute lymphoblastic leukaemia (ALL). Sensitive biomarkers are needed to guide CNS treatment intensity and identify patients at risk of CNS relapse. Currently, cerebrospinal fluid (CSF) cell counts and cytology are used to stage patients as CNS1 (no detectable CNS leukaemia), CNS2 (≤5 white blood cells (WBC)/µl, ≥2 visible blasts on cytospin), and CNS3 (&gt;5 WBC/µl with blasts or overt clinical CNS involvement). However, most CNS relapses occur in CNS1 patients, and the prognostic value of CNS2 disease is disputed. Wide va

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Ting-Gao, Yang, Shu Cheng-Gang, Fu Cheng-Qi, Jiang Dong-Rong, and Peng Qiu-He. "The Luminosity Function of the Main Sequence Stars in the Solar Neighborhood." Highlights of Astronomy 11, no. 1 (1998): 400. http://dx.doi.org/10.1017/s153929960002150x.

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The Third Catalogue of Nearby Stars (CNS3) was analyzed. A study of the stellar luminosity function in the solar neighborhood with CNS3 was described. The luminosity function for main sequence stars derived from CNS3 was compared with that from CNS2 and that based on the method of photometric parallaxes. The results from CNS3 for stars with Mv <15.5 were well defined. Luminosity functions for the giants and A, F, G, K and M type main sequence stars are also given, based on CNS3.

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Haddad, Rodrigo, Josiane Lilian dos Santos Schiavinato, Felipe Saldanha Saldanha-Araújo, et al. "Generation of Functional Regulatory T Cells From Umbilical Cord Blood Naïve T Cells: Potential Role of Hydroxymethylation in the Epigenetic Reprograming and Transcriptional Induction of FoxP3." Blood 120, no. 21 (2012): 4835. http://dx.doi.org/10.1182/blood.v120.21.4835.4835.

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Abstract Abstract 4835 The development and functionality of CD4+CD25hi regulatory T cells (Tregs) depends on stable FoxP3 expression, a central regulator of Treg differentiation. It is believed that this is accomplished by regulatory regions in the promoter and 3 evolutionarily conserved noncoding sequences, termed CNS1, CNS2 (or TSDR) and CNS3. The activation of TCR (with anti-CD2/3/28) in CD4+CD25− naïve T cells from PBMCs, in the presence of IL-2, TGF-β and atRA, induces the generation of Foxp3+ induced regulatory T cells (iTreg). While demethylation of 5mC residues in the CNS2 is associat

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Lee-Miller, Cathy A., John A. Kairalla, Emily Hibbitts, et al. "Additional Induction Intrathecal Cytarabine for Patients with CNS2 Disease at Diagnosis Is Not Beneficial for Patients with B-ALL Treated on Children's Oncology Group Protocols AALL0932 and AALL1131." Blood 144, Supplement 1 (2024): 4195. https://doi.org/10.1182/blood-2024-203456.

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Background: Children's Oncology Group (COG) trials AALL0932 and AALL1131 enrolled children with newly diagnosed National Cancer Institute (NCI) standard-risk (SR) and high-risk (HR) B-ALL from 2010-2019 and 2012-2019, respectively. In 2016, COG amended these trials to incorporate additional induction intrathecal (IT) therapy for patients with B-ALL and CNS2 status [CSF &lt;5/μL WBCs and cytospin positive for blasts; or traumatic lumbar puncture (LP) with ≥5/μL WBCs and cytospin positive for blasts that was negative by Steinherz/Bleyer algorithm]. Based on data demonstrating worse outcomes

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KUMAR, ASHOK, M. R. WILSON JOHN, K.RAJAN, and A. ANIMESH. "EFFECT OF HIGHER BLENDS OF CASHEW NUT SHELL OIL WITH DIESEL FUEL BY THERMAL BARRIER COATED PISTON IN A DIESEL ENGINE." Pollution Research 42, no. 01 (2023): 48–58. http://dx.doi.org/10.53550/pr.2023.v42i01.009.

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Swiftly developing industrialization, growing population, environmental threat, energy demands, have directed research towards alternative fuels. This experimental investigation aims to determine the temperature distributions by coating on piston crown to analyze the effect of higher blends (B30 & B40) of Cashew nut shell oil (CNSO) diesel blends and studied the combustion behavior. The thickness of the coating layer on the piston crown of the test engine are 500 ìm. Prior to coating, the surface of the crown area was grinded upto 500 μm so that the compression ratio of the existing engine

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Kumar, Ashok, K. Rajan, K. R. Senthil Kumar, K. Maiyappan, and Usama Tariq Rasheed. "Green fuel utilization for diesel engine, combustion and emission analysis fuelled with CNSO diesel blends with Diethyl ether as additive." IOP Conference Series: Materials Science and Engineering 197 (May 2017): 012013. http://dx.doi.org/10.1088/1757-899x/197/1/012013.

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Al-Quran, Ashraf Al, Faisal Al Al-Sharqi, Zahari Md Rodzi, et al. "The Algebraic Structures of Q-Complex Neutrosophic Soft Sets Associated with Groups and Subgroups." International Journal of Neutrosophic Science 22, no. 1 (2023): 60–76. http://dx.doi.org/10.54216/ijns.220105.

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Groups and subgroups are rich algebraic structures, and both of them depend on binary operations in their work. The discussion of this paper is organized into two parts. In the first part, we define the notion of Qcomplex neutrosophic soft sets (Q-CNSSs) by amalgamating two previous models of Q-complex neutrosophic set (Q-CNS) and soft set (SS) to address the issues of two-dimensionality (two variables) in a universal set under a parametric environment. Subsequently, the relation between Q-CNSSs and Q- neutrosophic soft sets (Q-NSSs) is verified. A basic set theory for this hybrid model is dev

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Fontela, Miguel G., Laura Notario, Elisenda Alari-Pahissa, Elena Lorente, and Pilar Lauzurica. "The Conserved Non-Coding Sequence 2 (CNS2) Enhances CD69 Transcription through Cooperation between the Transcription Factors Oct1 and RUNX1." Genes 10, no. 9 (2019): 651. http://dx.doi.org/10.3390/genes10090651.

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The immune regulatory receptor CD69 is expressed upon activation in all types of leukocytes and is strongly regulated at the transcriptional level. We previously described that, in addition to the CD69 promoter, there are four conserved noncoding regions (CNS1-4) upstream of the CD69 promoter. Furthermore, we proposed that CNS2 is the main enhancer of CD69 transcription. In the present study, we mapped the transcription factor (TF) binding sites (TFBS) from ChIP-seq databases within CNS2. Through luciferase reporter assays, we defined a ~60 bp sequence that acts as the minimum enhancer core of

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Normand, Charline, Estelle Thébaud-Léculée, Francoise Mazingue, et al. "Impact of Traumatic Lumbar Puncture on CNS Relapse in Children with Acute Lymphoblastic Leukemia." Blood 106, no. 11 (2005): 879. http://dx.doi.org/10.1182/blood.v106.11.879.879.

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Abstract Rationnal: In children with de novo acute lymphoblastic leukemia (ALL) event-free survival (EFS) and overall survival (OS) could be decreased when the diagnostic lumbar puncture is traumatic, as showed by two previous studies. The cerebrospinal fluid (CSF) should be contaminated with circulating leukemic blasts. Purpose: The aim of this study is to further investigate the influence of traumatic diagnostic lumbar puncture (LP) on CNS relapse rate as first endpoint and then on OS in a single center (Lille Academic Hospital, France) from 1989 to 2004. Patients and Methods: A total of 352

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Romdhini, Mamika Ujianita, Ashraf Al Al-Quran, Faisal Al Al-Sharqi, Mohammad K. Tahat, and Abdalwali Lutfi. "Exploring the Algebraic Structures of Q-Complex Neutrosophic Soft Fields." International Journal of Neutrosophic Science 22, no. 4 (2023): 93–105. http://dx.doi.org/10.54216/ijns.220408.

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A field is a fundamental algebraic structure that finds extensive applications in algebra and various mathematical domains. On the other hand, a Q-complex neutrosophic soft set (Q-CNSS) is a unique hybrid model that combines the characteristics of soft sets and neutrosophic sets within a complex number framework. It utilizes the effectiveness of Q-set as a powerful tool in the domain of this particular model. In this article, we leverage this model to define fields under uncertainty. We present the Q-complex neutrosophic soft field (Q-CNSF) and examine the unique algebraic properties associate

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Seca, Abdulai Ismail, Henrique Dos Santos Pereira, and Suzy Cristina Predroza da Silva. "Expansion of Cashew Cultivation and its Environmental and Economic Impacts on Guinea-Bissau." Revista Brasileira de Ciências Ambientais 56, no. 3 (2021): 385–97. http://dx.doi.org/10.5327/z21769478950.

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Guinea-Bissau has recently become the fifth largest producer and exporter in the world of Cashew Nut Shell (CNS) and the product accounts for 90% of the country’s total exports. The objective of this study was to analyze the expansion of cashew cultivation and its environmental and economic impacts on the country, from the perspective of sustainable development. In the methodology, correlational statistical analyses were used, based on multiple regression, correlation, and linear regression techniques. To qualify the empirical results based on the historical series of secondary data, an online

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Sambati, Vanessa, Serena Laudisio, Matteo Motta, and Susanna Esposito. "Therapeutic Options for Crigler–Najjar Syndrome: A Scoping Review." International Journal of Molecular Sciences 25, no. 20 (2024): 11006. http://dx.doi.org/10.3390/ijms252011006.

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Crigler–Najjar Syndrome (CNS) is a rare genetic disorder caused by mutations in the UGT1A1 gene, leading to impaired bilirubin conjugation and severe unconjugated hyperbilirubinemia. CNS presents in the following forms: CNS type 1 (CNS1), the more severe form with the complete absence of UGT1A1 activity, and CNS type 2 (CNS2), with partial enzyme activity. This narrative review aims to provide a detailed overview of CNS, highlighting its clinical significance and the need for new, more effective treatments. By summarizing current knowledge and discussing future treatments, this article seeks t

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Yue, Xiaojing, Sara Trifari, Tarmo Äijö, et al. "Control of Foxp3 stability through modulation of TET activity." Journal of Experimental Medicine 213, no. 3 (2016): 377–97. http://dx.doi.org/10.1084/jem.20151438.

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Ten-eleven translocation (TET) enzymes oxidize 5-methylcytosine (5mC) to 5-hydroxymethylcytosine and other oxidized methylcytosines, intermediates in DNA demethylation. In this study, we examine the role of TET proteins in regulating Foxp3, a transcription factor essential for the development and function of regulatory T cells (T reg cells), a distinct lineage of CD4+ T cells that prevent autoimmunity and maintain immune homeostasis. We show that during T reg cell development in the thymus, TET proteins mediate the loss of 5mC in T reg cell–specific hypomethylated regions, including CNS1 and C

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Robinson, Blaine W., Kajia Cao, Joanne M. Hilden, et al. "Age Is the Strongest Determinant of Leukemia Blast Cell Gene Expression in MLL-Rearranged Infant ALL and MLL-AF4 Directs a Distinct Gene Expression Profile Related to CNS Disease." Blood 112, no. 11 (2008): 1200. http://dx.doi.org/10.1182/blood.v112.11.1200.1200.

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Abstract In infant ALL a constellation of features (young age, hyperleukocytosis, extramedullary/CNS disease, CD10− phenotype, MLL translocation, slow early response to treatment) are associated with poor outcome. Despite the frequent MLL translocations, the biologic basis for these features is unknown. In this study, gene expression profiles of leukemia cells from diagnosis were determined in MLL-rearranged infant ALL and relationships were sought between gene expression and clinical covariates. Patients and Methods: Seventeen infants treated on COG protocol CCG 1953 were studied. Features at

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Eldadah, Saleem, Wasil Jastaniah, Ahmad Alsaeed, et al. "Treatment of adolescents and young adults with Philadelphia negative acute lymphoblastic leukemia (AYA Ph-ALL) using a risk and response based protocol with extended intensification and high dose methotrexate: A report from a single center in Saudi Arabia." Journal of Clinical Oncology 35, no. 15_suppl (2017): e18527-e18527. http://dx.doi.org/10.1200/jco.2017.35.15_suppl.e18527.

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e18527 Background: Studies have shown superior outcomes of AYA Ph-ALL when treated with pediatric or pediatric-inspired protocol. Since 2003 we used a modified Children’s Oncology Group (COG) protocol to treat AYA Ph-ALL aiming to improve outcomes. Methods: This study involved 67 consecutive patients aged 14-35 years with Ph-ALL diagnosed between October 2003 and March 2016. Patients with precursor B ALL, CNS1/CNS2, and negative day 29 minimal residual disease (MRD-) received single interim maintenance (IM) and delayed intensification (DI) (Arm B). While CNS3 or MRD+ patients received double I

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Hultquist, Haley, Alyssa Rodriguez, My H. Vu, Alexandra E. Kovach, and Paul S. Gaynon. "Initial Cerebrospinal Fluid Blast Clearance Rate in Pediatric B-Lymphoblastic Leukemia Is Associated with Overall Survival." Blood 144, Supplement 1 (2024): 4183. https://doi.org/10.1182/blood-2024-211645.

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Among children, B-lymphoblastic acute leukemia (B-ALL) is one of the most prevalent cancers, accounting for roughly a quarter of pediatric cancer cases. Children with disease in the central nervous system (CNS) at B-ALL diagnosis have higher risk clinical features and greater rates of relapse. At diagnosis, lumbar punctures (LP) collect cerebrospinal fluid (CSF) samples to allow for patient stratification based on CNS involvement: CNS1 = no blasts, CNS2 = blasts amid &gt;5 total white blood cells (WBC)/mm3, and CNS3 = blasts amid WBC ≥5/mm3 or grossly traumatic tap. Once diagnosis is confi

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Hasegawa, Daisuke, Atsushi Manabe, Akira Ohara, et al. "Significance of Initial Lumbar Puncture on Day8 of Remission Induction Therapy in Childhood Acute Lymphoblastic Leukemia: The Results from the Tokyo Children’s Cancer Study Group L99-15 Protocol." Blood 112, no. 11 (2008): 914. http://dx.doi.org/10.1182/blood.v112.11.914.914.

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Abstract Traumatic lumbar puncture with the presence of leukemic blasts (TLP+) in the cerebrospinal fluid (CSF) has been shown to adversely affect the outcome of children with acute lymphoblastic leukemia (ALL). In the Tokyo Children’s Cancer Study Group (TCCSG), we adopted a strategy to defer the initial lumbar puncture (LP) and intrathecal (IT) chemotherapy until 1 week after prednisolone (PSL) monotherapy so that circulating blasts were substantially reduced when the initial LP/IT was performed. The result of L89-12 study was previously reported, in which the incidence of TLP+ was significa

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Rheingold, Susan R., Lanyi Nora Chen, Shannon L. Maude, et al. "Efficient Trafficking of Chimeric Antigen Receptor (CAR)-Modified T Cells to CSF and Induction of Durable CNS Remissions in Children with CNS/Combined Relapsed/Refractory ALL." Blood 126, no. 23 (2015): 3769. http://dx.doi.org/10.1182/blood.v126.23.3769.3769.

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Abstract Background Relapsed/refractory pediatric acute lymphoblastic leukemia (ALL) poses a substantial therapeutic challenge. This is especially true in children with multiple central nervous system (CNS)/combined relapses that have been through radiation and bone marrow transplant (BMT) with no curative options left. We previously reported complete remissions (CR) and prolonged persistence of engineered T cells in children with ALL treated with CTL019 (CD19 CAR T cells). We now report on outcomes of 12 children with prior CNS relapse, isolated or combined with bone marrow (BM) relapse, trea

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Choi, John K., Sima Jeha, Jianbiao Zheng, Victoria Carlton, Malek Faham, and Ching-Hon Pui. "Assessment of Central Nervous System Involvement in Pediatric Acute Lymphoblastic Leukemia Patients Using Next-Generation Sequencing Method." Blood 126, no. 23 (2015): 4981. http://dx.doi.org/10.1182/blood.v126.23.4981.4981.

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Abstract Background: Successful outcome in childhood acute lymphoblastic leukemia (ALL) relies upon appropriate central nervous system (CNS)-directed therapy for treatment of subclinical or overt CNS leukemia. Patients with leukemia blasts detected in the cerebrospinal fluid (CSF) at diagnosis have poorer survival compared with patients without blasts in the CSF and require intensified intrathecal therapy to avert a higher rate of relapse. Traditionally, CSF assessment is performed by morphological analysis of CSF smears and the blasts confirmed by immunohistochemistry or flow cytometry. The c

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Atallah, Ehab, Susan O’Brien, Susan Kaled, et al. "Traumatic Lumbar Puncture (TLP) Is Not Associated with Worse Outcome in Adults with Acute Lymphocytic Leukemia (ALL) or Burkitt-Type Leukemia/Lymphoma (BLL) Receiving Hyper-CVAD Regimens." Blood 110, no. 11 (2007): 4346. http://dx.doi.org/10.1182/blood.v110.11.4346.4346.

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Abstract Background: TLP has been associated with worse outcome in pediatric ALL patients (pts). However, this has not been well studied in adults with ALL or BLL. Our aim was to investigate the prognostic significance of CNS status at presentation in adult ALL pts undergoing frontline therapy with hyper-CVAD (fractionated cyclophosphamide, vincristine, doxorubicin, and dexamethasone alternating with methotrexate and cytarabine) or variations incorporating rituximab and/or imatinib. Pts were stratified to receive standard intrathecal treatments (IT) with methotrexate alternating with cytarabin

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Kuznicki, Michelle L., Adrianne Mallen, Kristal Ha, et al. "Prognostic features of endometrial cancer metastasis to the central nervous system." PLOS ONE 17, no. 8 (2022): e0268794. http://dx.doi.org/10.1371/journal.pone.0268794.

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Objectives Central nervous system metastases (CNSm) secondary to endometrial cancer (EC) are rare. As a result, prognostic factors for this patient population are not well described. Methods EC patients with CNSm were identified retrospectively from two academic centers. EC patients without CNSm (non-CNSm) were used as controls. Chi-square and Fisher’s exact tests were used for analysis of categorial variables. Wilcoxon tests were used for quantitative measures. Overall survival (OS) was compared with Log-rank test. Cox proportional hazard models were used to estimate hazard ratios for OS. Res

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Mongwe, T., T. Ntuli, L. Sikeyi, et al. "The use of ex-situ nitrogen-doped olive oil-derived carbon nano-onions for application in chemi-resistive gas sensors to detect acetone at room temperature." South African Journal of Chemistry 76 (2022): 38–48. http://dx.doi.org/10.17159/0379-4350/2022/v76a07.

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This study reports on the synthesis of carbon nano-onions (CNOs; ca. d ≤ 55 nm) and nitrogen-doped CNOs (N-CNOs) using a facile pyrolysis method and ex-situ doping of the CNOs. Elemental analysis of the N-CNOs revealed that their nitrogen content depended on the ammonia flow rate. Analysis of the N-CNOs revealed that they all exhibited structural defects. After the successful synthesis of CNOs and N-CNOs, polyvinylpyrrolidone (PVP):CNOs/N-CNOs:MnO2-nanorods (MONRs) composites were prepared and used as active sensing materials. In every case, the PVP polymer was used to stabilize the MONRs for

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Sharp, John, Philip Young, Songzhu Zhao, et al. "A multi-center cohort study Examining risk factors for central nervous system metastases (CNSm) in patients with stage III non-small cell lung cancer (NSCLC) treated with definitive chemoradiation (ChemoRT) followed by durvalumab (Durva)." Journal of Clinical Oncology 42, no. 16_suppl (2024): 8076. http://dx.doi.org/10.1200/jco.2024.42.16_suppl.8076.

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8076 Background: In the PACIFIC trial, 6.3% of patients with unresectable stage III NSCLC receiving durva after chemoRT developed CNSm. In a single center study, we previously reported real-world incidence of CNSm is higher at 19.8%. Risk factors for development of CNSm post-durva are incompletely understood. Methods: We conducted a multi-center retrospective study of patients with unresectable stage III NSCLC treated with durva after chemoRT from 2018 to 2022 with no CNSm on baseline brain MRI to assess for incidence of CNSm. Patient characteristics were compared between cohorts with and with

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Feng, Zhenbao, Wei Ding, Yangming Lin, et al. "Electron momentum density of boron-doped carbon nano-onions studied by electron energy-loss spectroscopy." Physical Chemistry Chemical Physics 23, no. 46 (2021): 26343–48. http://dx.doi.org/10.1039/d1cp04334j.

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Kang, Ning, Jin Hua, Lizhen Gao, Bin Zhang, and Jiewen Pang. "The Interplay between Whey Protein Fibrils with Carbon Nanotubes or Carbon Nano-Onions." Materials 14, no. 3 (2021): 608. http://dx.doi.org/10.3390/ma14030608.

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Whey protein isolate (WPI) fibrils were prepared using an acid hydrolysis induction process. Carbon nanotubes (CNTs) and carbon nano-onions (CNOs) were made via the catalytic chemical vapor deposition (CVD) of methane. WPI fibril–CNTs and WPI fibril–CNOs were prepared via hydrothermal synthesis at 80 °C. The composites were characterized by SEM, TEM, FTIR, XRD, Raman, and TG analyses. The interplay between WPI fibrils and CNTs and CNOs were studied. The WPI fibrils with CNTs and CNOs formed uniform gels and films. CNTs and CNOs were highly dispersed in the gels. Hydrogels of WPI fibrils with C

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