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Artykuły w czasopismach na temat „Colon targeted tablets”

Autor: Grafiati

Data publikacji: 2 czerwca 2025

Data aktualizacji: 31 lipca 2025

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1

Dr.Shaikh, Siraj N* Mo. Irfan Mo.Hasnain Dr.G. J. Khan Shoaib Ahmad. "FORMULATION, OPTIMIZATION AND EVALUATION COLON TARGATED DRUG DELIVERY SYSTEM FOR ORNIADAZOLE." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES 05, no. 04 (2018): 3168–76. https://doi.org/10.5281/zenodo.1238402.

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The colon is a site where both local and systemic delivery of drugs can take place. The present investigation concerns with formulation and evaluation of Colon Targeted dip coated tablets of Ornidazole by using HPMCK4 M, Xanthan gum polymers .Initially core tablets were prepared and then coated by using Eudragit S100 as a enteric coating polymer with the help of Isopropyl alcohol, acetone (1:1) by deep coating. Optimization of colon targeted tablet of Ornidazole was carried out by using design expert software considering combination of HPMC K 4 M & Xanthan gum as independent variable &

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Jaiswal, Anamika, Ashok Koshta, Sapna Malviya, and Anil Kharia. "Formulation and Evaluation of Colon Targeted Matrix Tablets of Mesalazine." American Journal Of Pharmacy And Health Research 10, no. 12 (2022): 23–36. https://doi.org/10.5281/zenodo.7479322.

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ABSTRACT The present work involves the formulation of colon targeted matrix tablet of Mesalazine by using direct compression method. Excipients including in the formulation are Eudragit S100, Ethyl cellulose, Lactose, Talc, Magnesium stearate. Preformulation studies have also been performed to study the nature of API and compatibility of API with excipients by physical observation and TLC studies. The result showed that API was compatible with all the excipients selected. The tablets were formulated by direct compression method using the selected excipient quantities. The formulated tablets we

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K. Sunil kumar, R. G. Chandrakala, A. R. Sravanthi, P. Swarna latha, D. peeravali, and A. Vamsi. "Formulation and evaluation of colon targeted matrix tablet of ibuprofen." World Journal of Advanced Research and Reviews 18, no. 2 (2023): 519–35. http://dx.doi.org/10.30574/wjarr.2023.18.2.0562.

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The present work involves the formulation of colon targeted matrix tablet of Ibuprofen by using direct compression method. Literatures regarding, Ibuprofen tablet dosage form preparation, excipients selection, manufacturing method etc., has been collected and reviewed. In this work, selection of excipients was done based on a literature review. Excipients include Eudragit S100, Ethyl cellulose, Lactose, Talc, Magnesium stearate. Quantities of the excipients were selected performing FT-IR method which is an HIS of Fourrts India Laboratory. Preformulation studies have also been performed to stud

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K., Sunil kumar, G. Chandrakala R., R. Sravanthi A., Swarna latha P., peeravali D., and Vamsi A. "Formulation and evaluation of colon targeted matrix tablet of ibuprofen." World Journal of Advanced Research and Reviews 18, no. 2 (2023): 519–35. https://doi.org/10.5281/zenodo.8404828.

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The present work involves the formulation of colon targeted matrix tablet of Ibuprofen by using direct compression method. Literatures regarding, Ibuprofen tablet dosage form preparation, excipients selection, manufacturing method etc., has been collected and reviewed. In this work, selection of excipients was done based on a literature review. Excipients include Eudragit S100, Ethyl cellulose, Lactose, Talc, Magnesium stearate. Quantities of the excipients were selected performing FT-IR method which is an HIS of Fourrts India Laboratory. Preformulation studies have also been performed to stud

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5

Vemula, Sateesh Kumar, and Vijaya Kumar Bontha. "Colon Targeted Guar Gum Compression Coated Tablets of Flurbiprofen: Formulation, Development, and Pharmacokinetics." BioMed Research International 2013 (2013): 1–8. http://dx.doi.org/10.1155/2013/287919.

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The rationale of the present study is to formulate flurbiprofen colon targeted compression coated tablets using guar gum to improve the therapeutic efficacy by increasing drug levels in colon, and also to reduce the side effects in upper gastrointestinal tract. Direct compression method was used to prepare flurbiprofen core tablets, and they were compression coated with guar gum. Then the tablets were optimized with the support ofin vitrodissolution studies, and further it was proved by pharmacokinetic studies. The optimized formulation (F4) showed almost complete drug release in the colon (99

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N, Audinarayana, Anala Srinivasulu, Vellore Sruthikumari, Likitha, and Ananda Deepak V. "Colon targeting oral matrix tablets of mesalamine: Design, development and invitro evaluation." International Journal of Novel Trends in Pharmaceutical Sciences 10, no. 1 (2020): 18–27. http://dx.doi.org/10.26452/ijntps.v10i1.1144.

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The principle in this present research is to formulate Mesalamine containing colon targeted tablets by using different polymers and evaluate the effect of different polymers in drug release pattern. The matrix tablets of Mesalamine are formulated by polysaccharides based polymers like Cellulose acetate phthalate (CAP), Ethyl cellulose (EC), Guar gum (GG) and Xanthan gum (XG) which protects the drug to release in Stomach and Small Intestine. The invitro drug dissolution investigation of F2 (GG and XG) Matrix tablet was controlled by swelling into a viscous gel in colonic pH, which have been acc

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7

MD, Rawoof, Rajnarayana K, and Ajitha M. "Development and In Vivo Evaluation of Mesalazine Colon Targeted Tablets." International Journal of Pharmaceutical Sciences and Nanotechnology 12, no. 3 (2019): 4552–58. http://dx.doi.org/10.37285/ijpsn.2019.12.3.6.

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The main objective of the present study was to develop colon-targeted tablets of mesalazine by wet granulation method using 33 Response surface method with design of experiment software and HPMC K4M, Eudragit RL100, Ethyl cellulose and PVP K-30 used as pH dependent polymers. All the formulations (F1 to F27) were evaluated for the physicochemical parameters and were subjected to in vitro drug release studies. The amount of Mesalazine released from tablets at different time intervals was estimated by UV spectrophotometer. The formulation F26 released 98.16 % of mesalazine after 24 h, whereas mar

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8

Godge, GR, and SN Hiremath. "Development and evaluation of colon targeted drug delivery system by using natural Polysaccharides/Polymers." Dhaka University Journal of Pharmaceutical Sciences 13, no. 1 (2015): 105–13. http://dx.doi.org/10.3329/dujps.v13i1.21874.

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Colon is being extensively investigated as a drug delivery site. This study contains comparison of the usual enteric coating polymers viz. xanthan gum, guar gum, chitosan and ethyl cellulose, as carriers for colon specific drug delivery. Lactose based metoprolol succinate tablets were prepared. These were coated with one of the coating polymers to a varying coat thickness. Tablets were prepared using polysaccharides or synthetic polymer as binders. These included xanthan gum, guar gum, chitosan and ethyl cellulose. Metoprolol Succinate was used as a model drug. The prepared tablets were enteri

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Mobarak, Hussain, Das Biswajit, and Chakraborty Jashabir. "Formulation, Optimization and Evaluation of Capecitabine Tablet for Colon Specific Drug Delivery System." INTERNATIONAL JOURNAL OF PHARMACEUTICAL AND CLINICAL RESEARCH 09, no. 07 (2017): 539–49. https://doi.org/10.25258/ijpcr.v9i7.8788.

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Aim: The present research is focused on development and optimization of colon specific, fast disintegrating Capecitabine tablet for the treatment of Colon cancer. Methods: Colon targeted core tablet of Capecitabine was prepared by using CCS (Croscarmellose sodium) as a super disintegrating agent by direct compression method and coating was done over the core tablets by using pectin in different ratios by compression coating method. The colon targeted coating was done on the compression coated tablets by using ES100 and CAP (Cellulose acetate phthalate) in different ratios by dip coating method

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10

Vivekanandan, K. 1. *. Dr. Gunasekaran V. 2. "FORMULATION AND EVALUATION OF COLON TARGETED MATRIX FORMULATIONS OF BUDESONIDE OF PREDNISOLONE." Journal of Scientific Research in Pharmacy 7, no. 9 (2018): 96–101. https://doi.org/10.5281/zenodo.1421246.

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<strong><em>ABSTARCT</em></strong> <strong><em>I</em></strong><em>n the present research work sustained release matrix formulation of Budesonide targeted to colon by using various polymers developed. </em><em>Budesonide is a selective cyclooxygenase-2 inhibitor with pH-dependent solubility. To achieve pH-independent drug release of budesonide, pH modifying agents (buffering agents) were used. Colon targeted tablets were prepared in two steps. Initially core tablets were prepared and then the tablets were coated by using different pH dependent polymers. Ethyl cellulose, Eudragit L100 and S100 w

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11

Kumar, Lavi, Bhupendra Singh, Geetanjali Saini, et al. "Design, Formulation, Optimization and In-vitro Evaluation of Colon-targeted Tablet Utilizing Polymer Isolated from Artocarpus heterophyllus." INTERNATIONAL JOURNAL OF DRUG DELIVERY TECHNOLOGY 12, no. 03 (2022): 1112–19. http://dx.doi.org/10.25258/ijddt.12.3.31.

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Objective: The objective of the present study is to formulate, optimize, and evaluate the colon-targeted oral Tablet by utilizing the polymer obtained from Artocarpus heterophyllus. Ibuprofen was used as a model drug in the study. Methods: The Polymer was extracted from the fresh fruits of Artocarpus heterophyllus and subjected to identification and characterization. The formula of the Tablet was optimized using 3 factors 3 levels Box-Behnken design (Design Expert Software). The colon-targeted Tablets were then formulated and coated with pH-dependent polymer to avoid release in the upper gastr

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12

Reddy, Poreddy Srikanth, Penjuri Subhash Chandra Bose, Damineni Saritha, and Vuppula Sruthi. "FORMULATION AND EVALUATION OF COLON TARGETED MATRIX TABLET USING NATURAL TREE GUMS." International Journal of Pharmacy and Pharmaceutical Sciences 10, no. 9 (2018): 92. http://dx.doi.org/10.22159/ijpps.2018v10i9.27255.

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Objective: To develop a novel colon targeted tablet formulation using natural polysaccharides such as kondagogu gum and ghatti gum as carriers and diltiazem hydrochloride as a model drug.Methods: The polymer-drug tablets were prepared by wet granulation technique, coated with two layers viz., inulin as an inner coat followed by shellac as outer coat and evaluated for properties such as average weight, hardness and coat thickness. In vitro release studies of prepared tablets were carried out for 2 h in pH 1.2 HCl buffer, 3 h in pH 7.4 phosphate buffer and 6 h in simulated colonic fluid (SCF) in

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13

Anusha Gaddameedi and Anand Kumar Yegnoor. "Formulation and in vitro evaluation of compression coated mebeverine HCl tablets for colon targeting." GSC Biological and Pharmaceutical Sciences 23, no. 3 (2023): 019–29. http://dx.doi.org/10.30574/gscbps.2023.23.3.0210.

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The aim of the study was to develop colon targeted compression coated Mebeverine HCl (MEB) tablets using pH dependent, swellable and rupturable polymers for effective treatment of irritable bowel syndrome (IBS). The MEB loaded core tablets were prepared by direct compression method using CCM and CP as super disintegrating agents at different concentrations and evaluated for pre compression and post compression parameters. The optimized core tablets were further used to fabricate compression coated tablets using different ratios of Eudragit L100, Eudragit S100 as pH- dependent polymers, Keltone

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Anusha, Gaddameedi, and Kumar Yegnoor Anand. "Formulation and in vitro evaluation of compression coated mebeverine HCl tablets for colon targeting." GSC Biological and Pharmaceutical Sciences 23, no. 3 (2023): 019–29. https://doi.org/10.5281/zenodo.8260293.

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The aim of the study was to develop colon targeted compression coated Mebeverine HCl (MEB) tablets using pH dependent, swellable and rupturable polymers for effective treatment of irritable bowel syndrome (IBS). The MEB loaded core tablets were prepared by direct compression method using CCM and CP as super disintegrating agents at different concentrations and evaluated for pre compression and post compression parameters. The optimized core tablets were further used to fabricate compression coated tablets using different ratios of Eudragit L100, Eudragit S100 as pH- dependent polymers, Keltone

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Elias, Edwin J., Singhal Anil, Showkat Ahmad, and Anwar Daud. "Colon Targeted Curcumin Delivery Using Guar Gum." Natural Product Communications 5, no. 6 (2010): 1934578X1000500. http://dx.doi.org/10.1177/1934578x1000500621.

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Curcumin is used in the treatment of colon cancer, but its very poor absorption in the upper part of the GIT is a major concern. As a site for drug delivery, the colon offers a near neutral pH, reduced digestive enzymatic activity, a long transit time and an increased responsiveness to absorption enhancers. The aim of the present study was to identify a suitable polymer (guar gum) based matrix tablet for curcumin with sufficient mechanical strength and promising in vitro mouth-to-colon release profile. Three formulations of curcumin were prepared using varying concentrations of guar gum contai

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Sahu, Shilpa, Prasanta Kumar Choudhury, Gourishyam Pasa, Padala Narasimha Murthy, Poonam Sahu, and Renuka Verma. "Modulation of mesalamine release from enteric-coated matrix tablets using natural polysaccharides for localized colonic delivery." Journal of Applied Pharmaceutical Research 12, no. 2 (2024): 93–108. http://dx.doi.org/10.18231/j.joapr.2024.12.2.93.108.

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Background: Inflammatory bowel diseases (IBD) require effective colon-targeted drug delivery for improved therapeutic efficacy and minimized systemic side effects. Objectives: The objective of this research was to develop and evaluate novel colon-targeted matrix tablet formulations of mesalamine (5-aminosalicylic acid) for the treatment of IBD. Materials and Methods: Mesalamine matrix tablets were prepared by wet granulation technique using pH-sensitive polymers (HPMC K4M) and biodegradable natural polysaccharides (pectin, chitosan, and guar gum). Tablets were characterized for physicochemical

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Thulluru, Ashok, K. C. Anuradha, K. Saravanakumar, Nawaz Mahammed, Ch S. Phani Kumar, and K. Siva Jagan Mohan. "Colon targeted tablets of Albendazole with enhanced solubility by Complexation and Micellar Solubilization." International Journal of Research and Development in Pharmacy & Life Sciences 8, no. 3 (2019): 12–19. http://dx.doi.org/10.21276/ijrdpl.2278-0238.2019.8(3).12-19.

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Prasad, Garrepally. "Design and Optimization of Metformin Hcl of Colon Targeted Drug Delivery System." Journal of Clinical and Medical Case Reports and Reviews 1, no. 1 (2021): 1–4. http://dx.doi.org/10.59468/2837-469x/001.

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The aim of the present study was to develop colon targeted matrix tablets of Metformin HCl using various conc. of selected polymers such as HPMC, Ethyl Cellulose Guar gum and combination of the same. Tablets were prepared by direct compression method and both pre- compression and post- compression parameters for all batches shows in the acceptable ranges.Short term accelerated stability studies was performed according to ICH guidelines temperature of 400±20 and relative humidity of 75%±5% RH to study any physical changesand chemical decomposition of drug, no formulation shown any physical or c

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Abd Elbary, Ahmed, Howida K. Ibrahim, and Balquees S. Hazaa. "Formulation and evaluation of colon targeted tablets containing simvastatin solid dispersion." Drugs and Therapy Studies 1, no. 1 (2011): 16. http://dx.doi.org/10.4081/dts.2011.e16.

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Solid dispersions (SDs) of simvastatin with mannitol, Ineutic®, Pluronic® F-68, PEG 4000 and PVP K-30 were prepared and evaluated to deliver simvastatin to the colon in a pre-solubilized form. The formula of choice was compressed into fast disintegrating tablets using drug compatible excipients and was coated with Eudragit® S100 as a pH-responsive polymer. We investigated the effects of several variables related to both SD preparation (carrier type, combined carriers and drug to carrier ratio) and tablet coating (coat level and type of plasticizer) on drug dissolution. Differential scanning ca

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Pravin, Suruse, Godbole Mangesh, Bhamre Kumudini, and Shivhare Umesh. "Formulation and Evaluation of Colon Targeted Drug Delivery System." Indo Global Journal of Pharmaceutical Sciences 12 (2022): 115–21. http://dx.doi.org/10.35652/igjps.2022.12011.

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Purpose:The objective of the present study was to develop colon targeted drug delivery system of Metronidazole using guar gum as the carrier.Methods:Matrix tablets containing various proportions of guar gum were prepared by direct compression technique. Rapidly disintegrating Metronidazole core tablets were prepared and compression coated with guar gum and 20% of microcrystalline cellulose. The tablets were evaluated for hardness, thickness, drug uniformity and subjected to in vitro drug release studies under conditions mimicking mouth to colon transit. Results and Conclusions: The FTIR study

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JAHNAVI, SAI, GS Sharma, B. Rama, and ,. Jyothirani. "FORMULATION AND EVALUATION OF COLON TARGETED DRUG DELIVERY SYSTEM OF BUSULFAN: USING COMBINATION OF pH AND TIME DEPENDANT SYSTEMS." Journal of Drug Delivery and Therapeutics 9, no. 4-A (2019): 396–402. http://dx.doi.org/10.22270/jddt.v9i4-a.3437.

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In present work Colon targeting drug delivery system was developed for Busulfan an anticancer drug by using combination of delayed systems one is pH dependant and other is time dependant delayed system. Rapid release core tablet (RRCT) formulations were prepared using Busulfan drug with different disintegrating agents in different concentrations. The pre-compression and post-compression parameters of all formulations were determined and the values were found to be satisfactory. From the In-vitro dissolution studies, F6 formulation with 12% Hydroxy propyl cellulose (HPC) was the best formulatio

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Srinivasan, K., R. Suresh, S. Chandra, and N. Senthil Kumar. "Formulation and Evaluation of Gastro Resistant-Colon Targeted Drug Delivery System Containing Mesalazine Tablets." International Journal of Science and Research (IJSR) 12, no. 11 (2023): 377–85. http://dx.doi.org/10.21275/sr23830174058.

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Goli, Swathi. "Development of colon targeted matrix tablets of Metformin HCl using various concentration of selected polymers." Gastroenterology Pancreatology and Hepatobilary Disorders 1, no. 1 (2017): 01–02. http://dx.doi.org/10.31579/2641-5194/002.

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The aim of the present study was to develop colon targeted matrix tablets of Metformin HCl using various conc. of selected polymers such as HPMC, Ethyl Cellulose Guar gum and combination of the same. Tablets were prepared by direct compression method and both pre-compression and post- compression parameters for all batches shows in the acceptable ranges. Short term accelerated stability studies was performed according to ICH guidelines temperature of 400±20 and relative humidity of 75%±5% RH to study any physical changes and chemical decomposition of drug, no formulation shown any physical or

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Ofokansi, Kenneth Chibuzor, and Franklin Chimaobi Kenechukwu. "Formulation Development and Evaluation of Drug Release Kinetics from Colon-Targeted Ibuprofen Tablets Based on Eudragit RL 100-Chitosan Interpolyelectrolyte Complexes." ISRN Pharmaceutics 2013 (August 6, 2013): 1–8. http://dx.doi.org/10.1155/2013/838403.

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Colon-targeted drug delivery systems (CTDDSs) could be useful for local treatment of inflammatory bowel diseases (IBDs). In this study, various interpolyelectrolyte complexes (IPECs), formed between Eudragit RL100 (EL) and chitosan (CS), by nonstoichiometric method, and tablets based on the IPECs, prepared by wet granulation, were evaluated as potential oral CTDDSs for ibuprofen (IBF). Results obtained showed that the tablets conformed to compendial requirements for acceptance and that CS and EL formed IPECs that showed pH-dependent swelling properties and prolonged the in vitro release of IBF

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Vivekanandan, K. 1. *. Dr. Gunasekaran V. 2. "DEVELOPMENT OF COLON TARGETED SUSTAINED RELEASE MATRIX TABLETS OF PREDNISOLONE." Journal of Pharma Research 7, no. 9 (2018): 210–15. https://doi.org/10.5281/zenodo.1421240.

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<strong><em>ABSTARCT</em></strong> <strong><em>I</em></strong><em>n the present research work sustained release matrix formulation of prednisolone targeted to colon by using various polymers developed. </em><em>Various eudragit polymers were employed as polymers. Prednisolone dose was fixed as 20 mg. Total weight of the tablet was considered as 300 mg. Polymers were used in the concentration of 30, 60 and 90 mg concentration. All the formulations were passed various physicochemical evaluation parameters and they were found to be within limits. Whereas from the dissolution studies it was eviden

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Ch, Ramesh, Ramu B, and Rajkamal B. "Formulation of Colon Specific Didanosine Enteric Coated Matrix Tablets Using pH Sensitive Polymer." Pharmaceutical and Chemical Journal 3, no. 2 (2016): 207–20. https://doi.org/10.5281/zenodo.13754051.

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The objective of present study is to develop the colon specific Didanosine enteric coated matrix tablets using release retardant polymer and pH sensitive polymer Eudragit L100 that retard the liberation of drug in upper gastro intestinal system and also show progressive release in colon. The influence of core tablet compositions, polymer combination ratios and coating levels on the in vitro release rate of Didanosine from coated tablets was investigated. The results showed that less than 10% drug was released in 0.1 N HCl within 2 hr, and about 90% of the drug was released in the pH 7.4 phosph

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Kudupudi, Venkateswarlu, Ravi Shankar Kakarparthy, Prakash Nathaniel Kumar Sarella, and Venkata Ramana Murthy Kolapalli. "Formulation Development and Characterization of Vancomycin Hydrochloride Colon-Targeted Tablets Using In-Situ Polyelectrolyte Complexation Technique." International Journal of Pharmaceutical Sciences and Nanotechnology(IJPSN) 16, no. 3 (2023): 6533–45. http://dx.doi.org/10.37285/ijpsn.2023.16.3.7.

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Introduction: Vancomycin hydrochloride (VH) is an amphoteric glycopeptide antibiotic used to manage enterocolitis and pseudomembranous colitis. However, VH is prone to proteolytic degradation in the stomach, thus obscuring the drug entry into the colon. Colon-targeted drug delivery can prevent gastric degradation and localise the drug in the colon.  Methodology: The applicability of in situ polyelectrolyte complexation technique using the polymers Chitosan, Karaya gum, and Hupu gum at various concentrations along with enteric coating using Eudragit S100 was studied for the preparation of

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Ramanathan, M. "FORMULATION AND EVALUATION OF COLON TARGETED MATRIX TABLETS OF IBUPROFEN." Asian Journal of Pharmaceutical Research and Development 6, no. 2 (2018): 9–19. http://dx.doi.org/10.22270/ajprd.v6i2.366.

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Shaikh, M. S. "Double Coated Tablets of Nimesulide for Colon Targeting." International Journal of Pharmaceutical Sciences and Nanotechnology 3, no. 2 (2010): 1000–1005. http://dx.doi.org/10.37285/ijpsn.2010.3.2.14.

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The present study was aimed at developing oral colon targeted drug delivery system for Nimesulide utilizing recently designed and patented system called CODESTM, which consisted of a lactulose containing core overcoated with both Eudragit E and Eudragit L designed to rapidly disintegrate in the colon, in order to give a new life for an existing banned drug. CODESTM tablets were prepared by tabletting Nimesulide and lactulose, followed with film coating of Eudragit. The prepared tablets were evaluated on the basis of in vitro dissolution study and in vivo disintegration study was performed by g

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Hammad Ayaz, Muhammad Ahmad, Mustafa Kazmi, et al. "Formulation and evaluation of 5-fluorouracil controlled release chronotherapeutic drug delivery system (CTDDS) for colorectal cancer." Journal of Contemporary Pharmacy 6, no. 2 (2022): 65–72. http://dx.doi.org/10.56770/jcp2022624.

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Objective: As most of the drugs disintegrate and dissolve in stomach before reaching the target site and to substitute intravenous (IV) route based chrono modulated chemotherapy, oral colon target drug delivery system was formed. The aim of this study was to design, develop, and evaluate a colon targeted tablet containing 5-Fluorouracil (5-FU) to give a controlled release effect of drug for colonic cancer with a goal to increase the bioavailability and improve the patient compliance. Methods: Varied concentration of different polymers such as Xanthan gum and Eudragit were used to get an optimi

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Zou, Meijuan, Caixia Wang, Xuezhu Zhang, et al. "A suppository-base-matrix tablet for time-dependent colon-specific delivery system." Brazilian Journal of Pharmaceutical Sciences 50, no. 3 (2014): 535–41. http://dx.doi.org/10.1590/s1984-82502014000300012.

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Our research has focused on the main design features and release performances of time-dependent colon-specific (TDCS) delivery tablets, which relies on the relative constancy that is observed in the small intestinal transit time of dosage forms. But inflammatory bowel disease（IBD）can affect the transit time, and usually results in watery stool. Compared to the TDCS and wax-matrix TDCS tablet, a promising time-dependent colon-specific delivery system was investigated. In our study, a suppository-base-matrix coated tablet was evaluated. Water soluble suppository-base helps the expansion of table

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Kadam, Sagar, Pradip Yadav, and Dhananjay Landge. "Formulation and Evaluation of Colon Targeted Enteric Coated Tablets of Loperamide." Research Journal of Pharmacy and Technology 13, no. 3 (2020): 1447. http://dx.doi.org/10.5958/0974-360x.2020.00264.4.

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., Komal, Ujjwal Nautiyal, Ramandeep ,. Anita Devi Singh, and Anita Devi. "Primary and Novel Approaches in Colon Targeted Drug Delivery System: A Review." Indian Journal of Pharmaceutical and Biological Research 3, no. 02 (2015): 37–57. http://dx.doi.org/10.30750/ijpbr.3.2.5.

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Targeted drug delivery into the colon is highly desirable for local treatment of a variety of bowel diseases such as ulcerative colitis, Crohn’s disease, amoeabiasis , colonic cancer, local treatment of colonic pathologies, and systemic delivery of protein and peptide drugs. Colonic delivery refers to targeted delivery of drugs into the lower GI tract, which occurs primarily in the large intestine (i.e. colon). The colon specific drug delivery system (CDDS) should be capable of protecting the drug en route to the colon i.e. drug release and absorption should not occur in the stomach as well as

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Y. Al-hurr, Marwan. "Development of Modified Release Nicotine Tablet Formulation for Treatment of Ulcerative Colitis." Iraqi Journal of Pharmaceutical Sciences ( P-ISSN: 1683 - 3597 , E-ISSN : 2521 - 3512) 19, no. 2 (2017): 75–81. http://dx.doi.org/10.31351/vol19iss2pp75-81.

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One of the therapeutic effects of nicotine is used as a protective against developing ulcerative colitis . ulcerative colitis is an inflammatory disease of the bowel affecting the superficial lining mucosa in the rectum and large intestine. In this study nicotine tablets were formulated as modified release tablets targeted to the colon. All formulas were studied for drug release , effect of diluent, retardant concentration, avicel grade,and compression force, the selected formula was then further studied for drug release in 3 different pH ( coated tablets) .The kinetic study revealed acceptabl

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Tambe, Srushti, and Namita Desai. "Development and Evaluation of Bioresponsive Tablets of a Selective COX-2 Inhibitor for Colonic Delivery." Drug Delivery Letters 10, no. 1 (2020): 72–83. http://dx.doi.org/10.2174/2210303109666190828095726.

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Background: We report the effectiveness of a targeted delivery system containing Meloxicam using polysaccharides for the treatment of colorectal cancer. We also propose a novel biorelevant dissolution method to overcome drawbacks of existing dissolution methodologies of polysaccharidebased systems. The proposed method includes a mixture of probiotics cultured under anaerobic conditions in the presence of prebiotic in the in vitro dissolution study to surrogate colonic conditions. Polysaccharide- based system can be simple, safe and effective drug delivery system to target drugs to colon. Metho

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Ramasamy, Thiruganesh, Uma Devi Subbaih Kandhasami, Himabindhu Ruttala, and Suresh Shanmugam. "Formulation and evaluation of xanthan gum based aceclofenac tablets for colon targeted drug delivery." Brazilian Journal of Pharmaceutical Sciences 47, no. 2 (2011): 299–311. http://dx.doi.org/10.1590/s1984-82502011000200011.

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The objective of the present study is to develop a colon targeted drug delivery systems for Aceclofenac using xanthan gum as a carrier. In this study, multilayer coated system that is resistant to gastric and small intestinal conditions but can be easily degraded by colonic bacterial enzymes was designed to achieve effective colon delivery of Aceclofenac. The xanthan gum, the drug and the physical mixture were characterized by Fourier transform infrared spectroscopy (FTIR) and differential scanning calorimetry (DSC). All the formulations were evaluated for hardness, drug content uniformity and

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Naga Durga, D. Hema, T. Lakshmi Sowjanya, T. Pavani, and Lohithasu Duppala. "Formulation development and in-vitro evaluation of Molsidomine matrix tablets for colon specific release." Journal of Drug Delivery and Therapeutics 10, no. 2 (2020): 59–68. http://dx.doi.org/10.22270/jddt.v10i2.3900.

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Colon targeted tablets were prepared in two steps. Initially core tablets were prepared and then the tablets were coated by using different pH dependent polymers. Ethyl cellulose, Eudragit L100 and S100 were used as coating polymers. FT-IR studies were carried out to find out the possible interaction between the selected drugs and polymer. FT-IR studies revealed that there was no interaction between the selected drug and excipients. The pre-compression blend of all formulations was subjected to various flow property tests and all the formulations passed the tests. The tablets were coated by us

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Maity, Siddhartha, Amit Kundu, Sanmoy Karmakar, and Biswanath Sa. "In Vitro and In Vivo Correlation of Colon-Targeted Compression-Coated Tablets." Journal of Pharmaceutics 2016 (February 17, 2016): 1–9. http://dx.doi.org/10.1155/2016/5742967.

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This study was performed to assess and correlate in vitro drug release with in vivo absorption of prednisolone (PDL) from a colon-targeted tablet prepared by compression coating of core tablet. In vivo drug absorption study was conducted using a high performance liquid chromatographic (HPLC) method, which was developed and validated for the estimation of PDL in rabbit plasma. The calibration curve showed linearity in the concentration range of 0.05 to 50 μg/mL with the correlation coefficient (r) of 0.999. The method was specific and sensitive with the limit of detection (LOD) and lower limit

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Helmis, Mario, and Mont Kumpugdee-Vollrath. "Polymer Mixtures as Colon Targeted Drug Delivery Systems." Advanced Materials Research 690-693 (May 2013): 2131–36. http://dx.doi.org/10.4028/www.scientific.net/amr.690-693.2131.

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For the development of colon delivery systems (CDS) formulations have to be gastric resistant. The advantage of the CDS is the ability for a local treatment for colon diseases but also its systemic action. CDS can also increase the bioavailability of poorly water soluble drugs e.g. resveratrol, which can be degraded in the upper gastrointestinal tract or by the First-Pass-Effect. In this project the coating technique with different polymer mixtures containing Kollicoat MAE-30DP, Eudragit-NM, Eudragit-L, and Eudragit-NE was investigated. Resveratrol was used as a model drug and all formulations

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Godge, Ganesh, and Shivanand Hiremath. "Colonic delivery of film coated meloxicam tablets using natural polysaccharide polymer mixture." International Current Pharmaceutical Journal 1, no. 9 (2012): 264–71. http://dx.doi.org/10.3329/icpj.v1i9.11617.

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Now days natural polysaccharides are extensively used for the development of solid dosage forms for delivery of drug to the colon. The objective of the present study was to develop a site-specific drug, single unit formulation allowing targeted drug release in the colon. Solid unit dosage forms were prepared using polysaccharides or synthetic polymer included xanthan gum, pectin, chitosan and Eudragit-E. Meloxicam was used as a model drug. The prepared tablets were enteric coated with Eudragit-S 100 to give protection in the stomach. The coated tablets were tested in-vitro for their suitabilit

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Srilatha, K. S., Beulah Milton, and Dili RAJ Biswas. "Formulation and Evaluation Of Colon Targeted Drug Delivery System Of Edotolac Tablets." American Journal of PharmTech Research 8, no. 5 (2020): 63–74. http://dx.doi.org/10.46624/ajphr.2020.v8.i5.006.

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Kumar, Pravin, Babli Devi, Bhumika Thakur, and Mahendra Singh Ashawat. "Colon Targeted Press Coated Tablets of Venlafaxine Hydrochloride for Treatment of Depression." Current Psychopharmacology 7, no. 1 (2018): 69–82. http://dx.doi.org/10.2174/2211556007666180126112405.

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Soukhya, Joshi G. Saqib Akram Wani Sushma Touseef Vanishree K. H. Doddayya Ayesha Sultana* Pradnya B. Patil Sarfaraz MD. "Formulation And In-Vitro Evaluation of Compression Coated Core Tablets of Metronidazole for Colon Specific Drug Delivery." International Journal of Pharmaceutical Sciences 3, no. 5 (2025): 2380–86. https://doi.org/10.5281/zenodo.15421663.

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The study aimed to formulate and evaluate colon-specific compression-coated core tablets of Metronidazole for treating intestinal amoebiasis, focusing on improved efficacy, reduced dosing frequency, and enhanced patient compliance. Core tablets were prepared using wet granulation method with PVP K-30 as a binder and sodium starch glycolate as a disintegrant. Compression-coated tablets utilized varying ratios of chitosan and Carbopol 934P polymers. Granules were assessed for physical properties like angle of repose, bulk density, compressibility index, etc.  Tablets underwent tests for wei

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Malik, Mayank Kumar, Vipin Kumar, Vinoth Kumarasamy, et al. "Film Coating of Phosphorylated Mandua Starch on Matrix Tablets for pH-Sensitive Release of Mesalamine." Molecules 29, no. 13 (2024): 3208. http://dx.doi.org/10.3390/molecules29133208.

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Chemically modified mandua starch was successfully synthesized and applied to coat mesalamine-loaded matrix tablets. The coating material was an aqueous dispersion of mandua starch modified by sodium trimetaphosphate and sodium tripolyphosphate. To investigate the colon-targeting release competence, chemically modified mandua starch film-coated mesalamine tablets were produced using the wet granulation method followed by dip coating. The effect of the coating on the colon-targeted release of the resultant delivery system was inspected in healthy human volunteers and rabbits using roentgenograp

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Elkhodairy, Kadria A., Hanna A. Elsaghir, and Amal M. Al-Subayiel. "Formulation of Indomethacin Colon Targeted Delivery Systems Using Polysaccharides as Carriers by Applying Liquisolid Technique." BioMed Research International 2014 (2014): 1–17. http://dx.doi.org/10.1155/2014/704362.

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The present study aimed at the formulation of matrix tablets for colon-specific drug delivery (CSDD) system of indomethacin (IDM) by applying liquisolid (LS) technique. A CSDD system based on time-dependent polymethacrylates and enzyme degradable polysaccharides was established. Eudragit RL 100 (E-RL 100) was employed as time-dependent polymer, whereas bacterial degradable polysaccharides were presented as LS systems loaded with the drug. Indomethacin-loaded LS systems were prepared using different polysaccharides, namely, guar gum (GG), pectin (PEC), and chitosan (CH), as carriers separately

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Zartasha, Khalid, Tabassum Mahira, Razaque Ghulam, et al. "Formulation Development and Characteristics Assessment of Metronidazole Tablets (Colon Specific Coated)." Pakistan's Multidisciplinary Journal for Arts & Science 4, no. 2 (2023): 12–22. https://doi.org/10.5281/zenodo.7903316.

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<strong>Abstract</strong> The system of drug delivery mainly depends on targeted therapy synthesis that is the formulations active pharmaceuticals ingredients from drug will only be released target area, so the action generated by active pharmaceutical ingredients in specific time period depends on formulation of drug therapy. Colon specified drug targeted system either in the form of polymers or in single can be used to obtain the desired and needed therapeutic effect. FTIR were done of active ingredient (Metronidazole and polymers separately and their combination), pre-compression tests (Flo

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Anusha Gaddameedi and Anand Kumar Yegnoor. "QbD: A novel approach for formulation and optimization of colon targeted drug delivery system containing mebeverine HCl." Magna Scientia Advanced Research and Reviews 9, no. 1 (2023): 071–81. http://dx.doi.org/10.30574/msarr.2023.9.1.0123.

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The aim of the work is to study the programmed release of model antispasmodic drug Mebeverine HCl based on pulsatile principle to target colon proximity. Compression coated tablets included core tablet consisting of Croscarmellose as super disintegrant and pulsatile layer comprising impermeable Ethocel cup and mixture of Keltone, Eudragit S100, Ethocel as swellable and rupturable layer. The prepared core tablet was evaluated for weight variation, hardness, thickness, friability, drug content, disintegration time and in vitro dissolution studies. For optimization Box-Behnken design was employed

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Katole, Gayatri, Wadulkar R.D., Om M. Bagade, et al. "Formulation And Characterization of Lovastatin Tablets Enteric and Non-enteric Coated with Polymer Blends for Colon-specific Drug Release." Journal of Neonatal Surgery 14, no. 7S (2025): 318–30. https://doi.org/10.52783/jns.v14.2412.

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The study focused on developing a colon-specific drug delivery system for Lovastatin using β-cyclodextrin inclusion complexes and compression-coated tablets. The inclusion complexes were prepared via a kneading method, where Lovastatin was mixed with β-cyclodextrin in a 1:2 molar ratio. Core tablets were formulated using direct compression, incorporating Lovastatin, β-cyclodextrin, and excipients. These cores were subsequently coated with polymer blends of Inulin with either HPMC or Ethyl Cellulose to achieve colon-specific drug release. The swelling behaviour of the polymers was evaluated in

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P, Mahalakshmi, Suriyaprakash T N K, and S. Lakshmana Prabu. "Chronomodulated Delivery of Pantoprazole for Nocturnal Hyperacidity." International Journal of Pharmaceutical Sciences and Nanotechnology 8, no. 4 (2015): 3038–44. http://dx.doi.org/10.37285/ijpsn.2015.8.4.7.

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The objective of this work was to design and evaluate an oral site-specific, pulsatile drug delivery system containing Pantoprazole sodium which can be targeted to colon in a pH and time dependent manner, to modulate the drug level in synchrony with the circadian rhythm of nocturnal hyperacidity. Five different composition of Core tablets were prepared by direct compression technique. Based on the release studies of core tablets, nine different compositions of press coated tablets were prepared and analyzed. The press coated tablet further coated by using five different proportions of Eudragit

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S, Subimol, and Amjadkhan A. Pathan. "Formulation And In Vitro, In Vivo Evaluation of Colon Targeted Drug Delivery System Of 5-Fluorouracil." International Journal of Membrane Science and Technology 10, no. 3 (2023): 3753–67. http://dx.doi.org/10.15379/ijmst.v10i3.3636.

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Colon-targeted drug delivery systems can provide therapeutic benefits including better patient compliance and lower costs. The present investigation is aimed to design a colon specific microbially triggered system using biodegradable co-polymer mixtures. The calibration curves of 5-FU were measured in distilled water, 0.1N HCl and phosphate buffer of pH 6.8 and 7.4 which showed good linearity. Compatibility study of pure drugs, excipients and their physical mixtures were evaluated and passed as per standards. Solubility determination was carried out in different solvents. Satisfactory results

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