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Artykuły w czasopismach na temat „Combination tablet”

Autor: Grafiati

Data publikacji: 2 czerwca 2025

Data aktualizacji: 31 lipca 2025

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1

Wiendarlina, Ike Yulia, Mindiya Fatmi, Dwi Indriati, and Raraseta P. Novadin. "Preparation of Single Garlic, Red Ginger, Lemon and Apple Vinegar Combination Tablets By Wet Granulation Method." FITOFARMAKA: JURNAL ILMIAH FARMASI 13, no. 2 (2023): 130–38. http://dx.doi.org/10.33751/jf.v13i2.9320.

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Garlic, red ginger, lemon, and apple cider vinegar are spices in Indonesia that can be useful for increasing the body's resistance and preventing degenerative diseases. Tablet preparations are preferred because they are practical, easy to use, and easy to carry anywhere. The aim of this research is to see the effect of differences in the concentration of internal and external disintegrants, binders, gliders, and lubricants in each formula. Tablets are made with the single active ingredients of garlic, red ginger, apple cider vinegar, and lemon. The wet granulation method was chosen because nat

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P, Pavazhaviji, and Rajalakshmi A. N. "FIXED-DOSE COMBINATION DRUGS AS TABLET IN TABLET: A REVIEW." International journal of multidisciplinary advanced scientific research and innovation 1, no. 9 (2021): 169–77. http://dx.doi.org/10.53633/ijmasri.2021.1.9.02.

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The Pharmaceutical industry has become more interested in developing fixed-dose combinations (FDCs) in recent years. FDCs have been used successfully in a variety of clinical areas, including diabetes, HIV/AIDS,and cardiovascular diseases etc. FDCs are intended to extend the product life cycle and enhance patient compliance by decreasing cost. Active Pharmaceutical ingredients are chosen for FDC development based on variety of purposes such as Pharmacokinetic profile, drug-drug interactions, mechanism of action, and manufacturability for successful development. Tablet in tablet technology has

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Dipali, Kakade1 Shabnam khan2 Ramakant Sharma2 Jeevan Patel2 Shivani Khoware2 Rakesh Patel3. "Formulation and Evaluation of Montelukast levocetirizine Tablet." International Journal in Pharmaceutical Sciences 2, no. 3 (2024): 182–92. https://doi.org/10.5281/zenodo.10794492.

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Formulation and Evaluation of tablet containing combination of Montelukast and    Levocetirizine. The objective of present work is-To improve and increase the stability of both montelukast and Levocetirizine in combination as tablet. Enhancement of dissolution of Montelukast. To formulate and evaluate tablets of Levocetirizine and Montelukast for treating allergic rhinitis effectively. The begin with general introduction presenting overview about drugs for allergic rhinitis and combination of montelukast and Levocetirizine tablet. In the present research work, montelukast Levoce

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Luke, Stefani, Martha Ervina, and Lannie Hadisoewignyo. "Optimization of Coating Formula of White Pomegranate Peel Extract (Punica granatum L.) Film Coated Tablet Using Kollicoat Protect." Indonesian Journal of Pharmaceutical Research 1, no. 1 (2021): 19–27. http://dx.doi.org/10.31869/ijpr.v1i1.1993.

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White pomegranate peel has many kinds uses, one of them as antimalaria. The unpleasant appearance and bitter taste of white pomegranate peel tablet can be covered by film coated using Kollicoat Protect. This research aimed to determine the effect of concentration and type of solvent used as a coating on the physical properties of the coated tablets and determine the optimum formula. Tablets were made using direct compression method and then coated using Kollicoat Protect. The optimization of coating formula was performed using a factorial design with design expert software ver 10.0. Responses

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Akshay, Y. Sonawane Shubham S. Sonawane Jyoti Khapre. "Novel Approach And Current Applications Of Bilayer Tablet." International Journal in Pharmaceutical Sciences 2, no. 7 (2024): 1491–504. https://doi.org/10.5281/zenodo.12788774.

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The bi-layer tablet represents a new era in the successful creation of controlled release formulations with numerous characteristics to ensure successful drug delivery. Bi-layer tablets may be the best solution for avoiding chemical incompatibilities across APIs by physical separation and for developing distinct medication release patterns. A bi-layer tablet is appropriate for the sequential release of two medications in combination, as well as for the sustained release of a tablet, with one layer for rapid release as a loading dosage and the second layer for maintenance dose. As a result, the

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Sofyah, Titik Mardiyanti, Tukiran Tukiran, and Suyatno Sutoyo. "Antioxidant of Effervescent Tablet Formulated from Combination of Secang Wood and Red Ginger Extracts." Jurnal ILMU DASAR 23, no. 2 (2022): 121. http://dx.doi.org/10.19184/jid.v23i2.28136.

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Secang wood has strong antioxidant properties because it contains phenolic compounds such as flavonoids and brazilin. Also, red ginger has antioxidant derived from nonvolatile phenolic compounds. Until now, there has been no use of a combination of secang wood extract and red ginger specifically for the manufacture of effervescent tablets. The purpose of this study was to formulate an effervescent tablet by doing combination of secang wood and red ginger extracts with using various concentrations of citric and tartaric acids. The formulations conducted were three acid sources of 20%, 25%, 30%,

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Alkarib, Suad Y., and Deina E. MohamedElhassan. "Evaluation of Acacia- Guar Gum Combination as Delayed Release Coating Former on Solid Placebo Tablets." Journal of Advanced Pharmaceutical Science And Technology 2, no. 4 (2021): 1–10. http://dx.doi.org/10.14302/issn.2328-0182.japst-21-3700.

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Objectives The present study addresses evaluation of acacia-guar gum combination as an enteric former for tablet coating aiming to add knowledge on how develop the ability of enteric forming ability of acacia-guar combination. Methods Five formulations of enteric coating solution incorporating guar gum as delayed release polymers along with film coating material acacia gum followed by CMC and glycerin as plasticizer and coloring agents were prepared to coat placebo tablet cores. Different enteric coating formulations organized in different acacia : guar gum ratios as 1:1, 1:2, 1:3, 1:4 and 1:6

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Prof., Madhuri T. Deshmukh Ganesh Deokate *. Prof. R.V. Shete. "A REVIEW ON BILAYER TECHNOLOGY." Journal of Pharma Research 8, no. 3 (2019): 81–87. https://doi.org/10.5281/zenodo.2620324.

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<strong><em>ABSTRACT</em></strong> <strong><em>O</em></strong><em>ver the past 30 years, the expenses and complications involved in marketing new drug entities have increased with concomitant recognition of therapeutic advantages of controlled drug delivery. Now a days greater attention has been focused on development of controlled & immediate release drug delivery systems. Bi-layer tablet is suitable for sequential release of two drugs in combination and also for sustained release of tablet in which one layer is for immediate release as loading dose and second layer is maintenance dose. S

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Inamdar, Irfan, and Syed Iftequar Ahmed. "Bilayer tablet overview: A revolutionary approach in sustained drug release & combination drug therapy." Journal of Innovations in Pharmaceutical and Biological Sciences 10, no. 02 (2024): 08–19. http://dx.doi.org/10.56511/jipbs.2023.10302.

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A fresh method of administering drug, the bilayer tablet is a single dosage form containing 2 or more Active Pharmaceutical Ingredients (API).By incorporating two distinct layers, bilayer tablets provide improved drug release profiles and enhanced therapeutic efficacy. This review's objective is to pinpoint the challengesthat arise when making bilayer tablets and to suggest solutions for these difficulties. To help you better grasp bilayer tablets, types like double side presses, single side presses, and bilayer tablet displacement presses are discussed along with their uses, advantages, and d

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K, Kulkarni, and Deokar G. "From Challenges to Advancement for Bilayer Tablet Technology as Drug Delivery System." INTERNATIONAL JOURNAL OF DRUG DELIVERY TECHNOLOGY 14, no. 04 (2024): 1676–82. https://doi.org/10.25258/ijddt.14.4.64.

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Bilayer tablet technology is in focus because it advantageous for combination therapy, for combining two different release profile and it gives patent novelty to existing dosage. Hence its advantages, challenges and applications need to be discuss. The objective of preparing a review article on bilayer tablets is multifaceted, aiming to cover challenges at formulation development to scaleup and opportunity for new product development by integrating it bilayer tablet technology with other formulation technology. With reference to all the electronic data it was found that bilayer tablets face ma

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Swetanshu, ,., and Vijay Sharma. "Formulation, Optimization and Evaluation of Bilayer Tablet of Antihypertensive Drug." Journal of Drug Delivery and Therapeutics 9, no. 4 (2019): 704–8. http://dx.doi.org/10.22270/jddt.v9i4.3098.

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Hypertension or high blood pressure occurs when the high cardiac output exerts pressure on the arterial wall as the blood flow increases. Bi-layer tablets are prepared with one layer of drug for immediate release while second layer designed to release drug later, either as second dose or in an extended release manner. Bi-layered tablet is suitable for sequential release of two drugs in combination, separate two incompatible substances, and also for sustained release tablet in which one layer is immediate release as initial dose and second layer is maintenance dose. Bilayer tablet is suitable f

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Sa'adah, Hayatus. "OPTIMASI FORMULA EKSTRAK JAHE MERAH (Zingiber officinale) DENGAN METODE KEMPA LANGSUNG MENGGUNAKAN ANALISIS SIMPLEX LATTICE DESIGN." Jurnal Ilmiah Manuntung 1, no. 1 (2017): 47. http://dx.doi.org/10.51352/jim.v1i1.11.

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Processing of medicinal plants into the appropriate dosage form can ensure security during use. It is a motivation in making acceptable dosage form which is easy and convenient to use, especially the manufacture of ethanol extract red ginger tablets using a combination of starch 1500 and amprotab.The study begins with the manufacture of dry extract of red ginger. Optimization of making tablets using a combination of starch 1500 and disintegrator with simplex lattice design using three formulas is done by direct compaction method. Further testing on the tablet hardness, friability and disintegr

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13

Ermawati, Dian Eka, Rido Rohana Tambunan, and Ulfa Afrinurfadhilah Darojati. "The Effect of Combination of Porang Tuber Starch (Amorphophallus muelleri Blume) with Lactose on the Physical Properties of Bajakah Root (Spatholobus littoralis Hassk) Water Extract’s Tablet." Journal of Pharmaceutical Sciences and Community 21, no. 1 (2024): 17–22. http://dx.doi.org/10.24071/jpsc.005765.

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Kalimantan's people drink bajakah roots as a traditional medicine to restore stamina and treat various diseases. The infusion is less practical and unstable, so it was developed into a tablet. Porang is a local tuber that contains amylum and amylopectin. The combination of starch-lactose has been widely used as a tablet filler and produces tablets with good physical properties. This study aimed to determine the effect of the combination of porang starch-lactose on the granules and tablets' physical properties. Bajakah roots were infused and dried using a freeze-dryer. The antioxidant activity

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Sahasrabuddhe, Vishakha, M. Alagusundaram, Vijeta Bhattacharya, Namrata Mishra, and Priyanka Keshri. "Formulation and Evaluation of Ascorbic Acid Mouth Dissolving Tablets." Asian Journal of Basic Science & Research 06, no. 02 (2024): 167–82. http://dx.doi.org/10.38177/ajbsr.2024.6213.

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Mouth dissolving tablet have better accessibility and tolerability for patients, mouth dissolving tablet is the most essential and recommended way of drug delivery. One more difficulty can be solved by administering the new drug with the mouth dissolving tablet formulation so that the drug quickly dissolves and breaks in the mouth in fewer minute due to the effect of super disintegrating agents that maximize the pore structure of the formulation. The purpose of this research work was to develop mouth-dissolving tablet of Ascorbic Acid. Tablet containing drug and excipients were prepared by dir

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Gangurde, Gayatri* Dhum Manohar Gavali Prashant Sonawane Mitesh. "Review on Bilayer Tablets." International Journal of Pharmaceutical Sciences 3, no. 3 (2025): 1192–203. https://doi.org/10.5281/zenodo.15019244.

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Bi-layer tablets are essential for developing both immediate and modified drug delivery systems for various diseases. They facilitate controlled medication release, representing a significant advancement in Controlled Drug Delivery Systems (CDDS) and improving the effectiveness of medication delivery. Over the past 30 years, the complexity and costs of introducing new drugs have increased, leading to greater focus on sustained or controlled release systems. Bi-layer tablets enable precise delivery of medications with predetermined release profiles, preventing chemical incompatibilities between

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Davydova, V. V., E. F. Stepanova, A. M. Shevchenko, A. S. Chiriapkin, A. S. Pleten, and A. A. Prokopov. "Development of technology and study of combination tablets of prednisolone and loratadine with modified release." Russian Journal of Biotherapy 23, no. 2 (2024): 85–92. http://dx.doi.org/10.17650/1726-9784-2024-23-2-85-92.

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Background. Allergies are a global medical and social problem. According to international statistics, the number of allergic diseases has increased dramatically in recent decades. In recent years, the largest increase in the incidence of bronchial asthma, pollinosis and dermatoses has been noted. Currently, significant success has been achieved in understanding the causes and mechanisms of allergic inflammation and in forming approaches to the treatment of allergic diseases. Among second-generation antihistamines, loratadine, an effective antiallergic drug, is excreted. However, in the pharmac

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Al-anbagi, Mina Shihab, Nawal A. Rajab, Mohammed Abd-Alhussein Aljodah, and Zaid Al-Attar. "Preparation and Characterization of Sumatriptan Timed Delivery System Using Combination of Natural and Synthetic Polymers." Open Access Macedonian Journal of Medical Sciences 10, A (2022): 432–43. http://dx.doi.org/10.3889/oamjms.2022.8358.

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BACKGROUND: Pulsatile drug delivery systems are time-controlled dosage forms that release active pharmaceutical component after a predefined period in order to synchronize circadian cycle of illness. Migraine has a diurnal cycle, with episodes peaking between 6 a.m. and 8 a.m. Sumatriptan acts as a selective agonist for 5-Hydroxytryptamine1 (serotonin) receptors. Thus, it is an effective therapy for acute migraine episodes. AIM: The objective of the study is to create a time-controlled press-coated tablet containing two sumatriptan pulses. The first pulse demonstrated 100% active component rel

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Oldfield, Vicki, and Caroline M. Perry. "Oxycodone/Ibuprofen Combination Tablet." Drugs 65, no. 16 (2005): 2337–54. http://dx.doi.org/10.2165/00003495-200565160-00011.

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Singh, Jyoti Bhusan, Pramod Mourya, Gopal Rai, and Rajesh Shukla. "FORMULATION AND IN-VITRO EVALUATION OF NICARDIPINE HYDROCHLORIDE BILAYERED TABLET FOR CONTROLLED RELEASE." Journal of Advanced Scientific Research 13, no. 11 (2022): 58–62. http://dx.doi.org/10.55218/jasr.2022131109.

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The aim of present research work was to prepare and evaluate the controlled release bilayered tablet of Nicardipine HCL to improve its bioavailability for the treatment of hypertension. To minimize critical process parameters, two layer compression method was used for the formulation of Bilayered tablets. The appropriate formulation was achieved successfully with the combination of Polymers MCC, Carbopol 71G and HPMC K100M produced desired release profile for Metoprolol succinate extended release layer. The combination of disintegrating agents that is Sodium starch glycolate and Dicalcium phos

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Journal, Devanshi, Dibya Kumari, and Umesh Kumar Jain. "Formulation and Evaluation of Gastroretentive Bilayer Tablets." Journal of Drug Delivery and Therapeutics 14, no. 9 (2024): 107–12. http://dx.doi.org/10.22270/jddt.v14i9.6784.

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Gastroretentive bilayer tablets were designed to prolong the gastric residence time after oral administration and to achieve immediate release of lansoprazole and controlled release floating layer of clarithromycin to treat gastric ulcers. Instant release layer has a combination of super disintegrating agents. A combination of effervescent mechanism is used. HPMC K5 was used as swelling polymer and citric acid, sodium bicarbonate as gas generating agent to reduce the floating lag time. Bilayer floating tablets were prepared with varying proportions of instant layer and sustained release floati

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Rokhmah, Nisa Najwa, Erni Rustiani, and Muhamad Nur Ambiya. "EFEKTIVITAS ANTIDIABETES TABLET POLIHERBAL PADA MODEL TIKUS DIABETIK." PROSIDING SERINA 1, no. 1 (2022): 21–30. http://dx.doi.org/10.24912/pserina.v1i1.15384.

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Cinnamon bark (Cinnamomum burmanii), Phaleria macrocarpa fruit, moringa leaves (Moringa oleifera L.), and bay leaves (Syzygium polyanthum) are plants that often used for the treatment of diabetes mellitus. Each plant's antidiabetic activity is known, but the plant combination's synergistic effect is not apparent. The concept of polyherbal is to increase the therapeutic effect and decrease the concentration of a single polyherbal extract. The possibility of changing the bioavailability of polyherbal products in the form of simplicia into tablet form is a big challenge. This result was to test t

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Bhalekar, Mangesh Ramesh, Nitin Madhukar Kadam, Nilam Hindurao Patil, Nitin Somnath Gawale, and Ashwini Madgulkar. "Novel ion exchange resin-based combination drug-delivery system for treatment of gastro esophageal reflux diseases." Brazilian Journal of Pharmaceutical Sciences 46, no. 2 (2010): 335–42. http://dx.doi.org/10.1590/s1984-82502010000200021.

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The present study involves preparation and characterization of a combination tablet of ranitidine in immediate release form and domperidone in sustained release form, using ion exchange resins. Ranitidine lowers acid secretion, while domperidone release over a prolonged period improves gastric motility thus justifying this combination in gastro esophageal reflux diseases (GERD) and ensuring patient compliance. Drug loading was carried out by batch method & resinates were characterized using FTIR, XRPD. Resinates were formulated as a combination tablet and evaluated for tablet properties &a

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Ullah, Ghufran, Asif Nawaz, Muhammad Shahid Latif, et al. "Clarithromycin and Pantoprazole Gastro-Retentive Floating Bilayer Tablet for the Treatment of Helicobacter Pylori: Formulation and Characterization." Gels 9, no. 1 (2023): 43. http://dx.doi.org/10.3390/gels9010043.

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Bilayer/multilayer tablets have been introduced to formulate incompatible components for compound preparations, but they are now more commonly used to tailor drug release. This research aimed to formulate a novel gastro-retentive tablet to deliver a combination of a fixed dose of two drugs to eliminate Helicobacter pylori (H. pylori) in the gastrointestinal tract. The bilayer tablets were prepared by means of the direct compression technique. The controlled-release bilayer tablets were prepared using various hydrophilic swellable polymers (sodium alginate, chitosan, and HPMC-K15M) alone and in

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Eva monica, Rollando Rollando, Rehmadanta Sitepu, Devi Rusvita Khoirul Nisah, Laurensia Nina Irawati, and Sinta Dwi Larasati Listio. "Formulation of Fast Disintegrating Tablet Paracetamol Employing Selected Super-disintegrant." International Journal of Research in Pharmaceutical Sciences 11, no. 3 (2020): 4323–33. http://dx.doi.org/10.26452/ijrps.v11i3.2648.

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The objective of this research was to investigate paracetamol FDT formula with potato starch and xanthan gum or glycine or ac di sol combination that can produce the best tablet quality. The tablets were prepared by direct compression technique. Superdisintegrant such as Glycine, Ac di sol, Xanthan Gum, and Potato Starch Extract was optimized as 1-19 % on the basis of least disintegration time. Binders such as HPMC were optimized along with optimized superdisintegrant concentration. 3,5% HPMC was selected as optimum binder concentration on the basis of least disintegration time. Granule parame

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Tambe, Sujit T., Harshad B. Padekar, S. M. Dhobale, and S. L. Jadhav. "Design and Characterisation of Bi-layer Tablets Containing Simvastatin as Sustained Release and Labetalol HCl as Immediate Release." Journal of Drug Delivery and Therapeutics 9, no. 2-s (2019): 263–70. http://dx.doi.org/10.22270/jddt.v9i2-s.2508.

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The objective of present investigation is to design and characterise sustained release Simvastatin and immediate release of Labetalol HCl, a bi-layer tablet. The combination therapy of Simvastatin and Labetalol HCl can be useful in severe cardiovascular disease such as hypertension, angina pectoris, congestive heart failure which may occur along with increasing cholesterol level in the blood, while this combination remain preferable choice to the patient as compared to single dosage form. The bi-layer tablet is suitable for sequential release of two drugs in combination which are compatible wi

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Yun, Tae Han, Moon Jung Kim, Jung Gyun Lee, Kyu Ho Bang, and Kyeong Soo Kim. "Enhanced Stability and Compatibility of Montelukast and Levocetirizine in a Fixed-Dose Combination Monolayer Tablet." Pharmaceutics 16, no. 7 (2024): 963. http://dx.doi.org/10.3390/pharmaceutics16070963.

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The purpose of this study was to enhance the stability of montelukast and levocetirizine for the development of a fixed-dose combination (FDC) monolayer tablet. To evaluate the compatibility of montelukast and levocetirizine, a mixture of the two drugs was prepared, and changes in the appearance characteristics and impurity content were observed in a dry oven at 60 °C. Excipients that contributed minimally to impurity increases were selected to minimize drug interactions. Mannitol, microcrystalline cellulose, croscarmellose sodium, hypromellose, and sodium citrate were chosen as excipients, an

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Sipos, Emese, Andrea Ramona Oltean, Zoltán-István Szabó, Emőke-Margit Rédai, and Gabriella Dónáth Nagy. "Application of SeDeM expert systems in preformulation studies of pediatric ibuprofen ODT tablets." Acta Pharmaceutica 67, no. 2 (2017): 237–46. http://dx.doi.org/10.1515/acph-2017-0017.

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Abstract Pediatric, ibuprofen containing orodispersible tablets (ODTs) were prepared using the SeDeM expert system methodology. In order to facilitate formulation, directly compressible ibuprofen was employed (Ibuprofen DC 8TM) and characterized using its SeDeM profile. The mannitol based superdisintegrant Ludiflash® was characterized by the SeDeM-ODT expert system, which also allowed calculation of the optimal excipient concentration in order to obtain suitable tablet hardness and disintegration time. After adding a sweetener and a standard combination of lubricants, the optimized formulation

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K., Rekha Rani* Y. Navya Reddy R. Mohana Priya. "FORMULATION AND EVALUATION OF SUSTAINED RELEASE DOSAGE FORM OF KETOPROFEN." indo American Journal of Pharmaceutical Sciences 04, no. 05 (2017): 1384–90. https://doi.org/10.5281/zenodo.804916.

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Sustained release Ketoprofen matrix tablets were prepared by direct compression method. The nature of the polymer influences the physical and release characteristics of the matrix tablet. The hydrophobic polymer, Ethyl cellulose has retarded the drug release from the tablet and the hydrophilic polymer, HPMC (15 cps) has release the drug. While making the combination of both hydrophilic and hydrophobic polymers i.e HPMC and Ethylcellulose with optimized ratio (F7) leads to sustained release of drug from matrix tablet for 12 hours was observed Key words: Ketoprofen, HPMC (15 cps), Ethyl cellulos

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Blatnik, Sandra Urek, Rok Dreu, and Stanko Srčič. "Influence of pH modifiers on the dissolution and stability of hydrochlorothiazide in the bi- and three-layer tablets." Acta Pharmaceutica 65, no. 4 (2015): 383–97. http://dx.doi.org/10.1515/acph-2015-0031.

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Abstract During the past few years, the studies of bi- and multi-layered tablets increased due to the consumption of several different drugs per day by a patient and requests for appropriate patient compliance. The demographic shift toward older population increases the use of combination therapy as polypharmacy. Hydrochlorothiazide (HCTZ), as a model drug, is most commonly used in the treatment of hypertension, congestive heart failure and as a diuretic. The aim of the present study is to investigate the effect of the local environment on dissolution and stability behaviour of HCTZ in fixed m

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Rustiani, Erni, Rina Agustina, and Septia Andini. "Formulation and Pharmaceutical Quality Evaluation of Tablets Containing Extract of Cinnamomum burmannii BARK and Colocasia esculenta (L) Schott Leaves." Jurnal Mandala Pharmacon Indonesia 9, no. 1 (2023): 27–34. http://dx.doi.org/10.35311/jmpi.v9i1.292.

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Cinnamon bark (Cinnamomum burmannii) is used traditionally and has an ingredient containing cinnamic acid compounds. Colocasia esculenta (L) Schott leaves contains of flavonoids, alkaloids, tannins, saponins, steroids, and terpenoids. Both of the plants C. esculenta and C. burmannii plants have the potential as anti-diabetics because they can lower blood glucose levels. This study aims to make combination tablets of C. burmannii bark and C. esculenta leaves extract with various concentrations of PVP K30 binder. This research made four formulas with the concentration of PVP K30, namely F1 (2%),

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Satyajit, Panda, Mishra Bibaswan, and Behera Swayamprava. "Bi-Layer Tablets: An Emerging State of Art Technology in Dosage Form Design." Journal of Advances in Nanotechnology and its Applications 3, no. 2 (2021): 1–14. https://doi.org/10.5281/zenodo.5515151.

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<em>Despite significant advancements in dosage form design, oral route still remains the most favoured route of drug administration. Even now-a-days tablets have got more attention compared to other dosage forms because of simple, inexpensive, greater stability and most suitable nature of tablets. More recently major considerations in tablet sector have been focused on development of controlled and immediate release drug delivery systems. Many pharmaceutical manufacturers are giving more emphasis to bi-layer tablet sector now a day, because of several advantages like extension of patent, impro

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Andini, Septia, Siti Sa’diah, and Suci Puspa. "Preparasi dan Karakteristik Floating Tablet Ekstrak Daun Jambu Biji (Psidium guajava L.) dengan Variasi Kombinasi Xanthan Gum dan HPMC." Jurnal Sains dan Kesehatan 4, no. 4 (2022): 370–78. http://dx.doi.org/10.25026/jsk.v4i4.1226.

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Floating drug delivery system (FRDDS) is a new drug delivery system that is intended to prolong the time of drugs in the stomach. One form of the gastroretentive system is a floating tablet, which can float and stay in the stomach for some time. Preparations with this system are suitable for use in drugs that have an action on the stomach. Gastritis is defined as an inflammation or swelling of the inner lining of the stomach. Guava leaves are proven to have active ingredients that can act as anti-ulcers. This study aims to formulate floating tablets and determine the optimal combination of HPM

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&NA;. "Entacapone/Levodopa/Carbidopa Combination Tablet." Drugs in R & D 4, no. 5 (2003): 310–11. http://dx.doi.org/10.2165/00126839-200304050-00006.

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NIZAMI, FARIDA, and YOGENDRA MALVIYA. "RECENT ADVANCEMENT AND CHALLENGES IN BILAYER TABLET TECHNOLOGY: AN OVERVIEW." Current Research in Pharmaceutical Sciences 11, no. 4 (2022): 91–97. http://dx.doi.org/10.24092/crps.2021.110401.

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Bilayer tablets were developed recently for the effective production of controlled release formulations in various quality levels to give a method of successful drug delivery. Over the last three decades, as the cost and complexity of developing novel pharmacological entities have increased and as the therapeutic benefits of controlled drug administration have been recognized, considerable attention has been focused on developing sustained or controlled release drug delivery systems. It is utilized to produce a variety of antihypertensive formulations. Bilayer tablets allow for the predetermin

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Syahrina, Dahlia, and Noval Noval. "Optimasi Kombinasi Asam Sitrat dan Asam Tartrat sebagai Zat Pengasam pada Tablet Effervescent Ekstrak Ubi Jalar Ungu (Ipomoea batatas L)." Jurnal Surya Medika 7, no. 1 (2021): 156–72. http://dx.doi.org/10.33084/jsm.v7i1.2651.

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Purple sweet potato has the content of anthocyanin compounds that are efficacious as antioxidants. To deliver these efficacious compounds, formulations of effervescent tablets are required as antioxidants with a combination of citric acid and tartrate acid to accelerate the solubility of the drug. The research aims to optimize the combination of citric acid and tartrate acid as a sourgent on effervescent tablets of purple sweet potato extract using the simplex lattice design method. The manufacture of tablets using a direct pumping method with effervescent powder evaluation includes flow rate

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Ting, Susan. "Liquid Chromatographic Determination of Levodopa and Levodopa-Carbidopa in Solid Dosage Forms: Collaborative Study." Journal of AOAC INTERNATIONAL 70, no. 6 (1987): 987–90. http://dx.doi.org/10.1093/jaoac/70.6.987.

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Abstract A liquid chromatographic method for the determination of levodopa in tablets and capsules and levodopa-carbidopa in tablets was collaboratively studied by 6 laboratories. Collaborators were supplied with duplicate powdered composites of levodopa (1 synthetic formulation, 1 commercial tablet, and 1 commercial capsule) and levodopa- carbidopa (1 synthetic formulation and 2 commercial tablets), along with individual levodopa-carbidopa tablets for content uniformity determinations. The repeatability coefficient of variation (CV„) and reproducibility coefficient of variation (CV„) for levo

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Akintunde, J. K., J. A. Ajiboye, E. O. Siemuri, and O. O. Olabisi. "Fansidar drug induces cytotoxicity in some vital tissues in a rat model: combination defensive effect of selenium and zinc capsules." Therapeutic Advances in Drug Safety 12 (January 2021): 204209862110271. http://dx.doi.org/10.1177/20420986211027101.

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Aim: Fansidar (FAN) is widely used as an antimalarial drug, but it may cause hepatoxicity, nephrotoxicity, and neurotoxicity. Hence, the study examines the cytoprotection of selenium (Se) and zinc (Zn) tablets against FAN induced toxicity. Method: Group I was given distilled water. Groups II, III, IV, and V received 50 mg/kg FAN by gavage. Group III was co-treated with a 50 mg/kg Se tablet. Group IV was co-treated with a 50 mg/kg Zn tablet. Group V was co-treated with a 50 mg/kg Se tablet + 50 mg/kg Zn tablet. The exposure lasted for 7 days (sub-acute exposure). Result: FAN causes cytotoxicity

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Viswanad, Vidya, Shammika P, and Aneesh Tp. "FORMULATION AND EVALUATION OF SYNTHESIZED QUINAZOLINONE DERIVATIVE FOR COLON SPECIFIC DRUG DELIVERY." Asian Journal of Pharmaceutical and Clinical Research 10, no. 3 (2017): 207. http://dx.doi.org/10.22159/ajpcr.2017.v10i3.16024.

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ABSTRACTObjective: The current research deals with the formulation and evaluation of synthesized quinazolinone derivative for colon site specific delivery.Methods: The synthesized quinazolinone derivative was enteric coated 5% Eudragit L-100 with by wet granulation method using guar gum, pectin,and guar gum pectin combination as hydrophilic polymer. The prepared matrix tablet was characterized by differential scanning calorimetry andevaluated for different pre-compression and post-compression studies and drug release profiles.Results: All the matrix tablets were within the range of pharmacopei

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Triastutik, Irsalina, Lusia Oktora Ruma Kumala Sari, and Lina Winarti. "Optimasi Hydroxypropyl Methylcellulose dan Chitosan pada Tablet Floating-Mucoadhesive Diltiazem Hidroklorida Menggunakan Desain Faktorial." Pustaka Kesehatan 8, no. 3 (2020): 159. http://dx.doi.org/10.19184/pk.v8i3.11419.

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Diltiazem HCl is one of the drugs used for hypertension treatment. It requires frequent dosing, which is why diltiazem HCl needs to be formulated into preparations using a controlled release drug delivery system. The combination of floating and the mucoadhesive system is expected to increase the stomach's retention of the dosage form. This study aimed to determine the optimum composition of hydroxypropyl methylcellulose (HPMC K100M) and chitosan for floating mucoadhesive diltiazem HCl tablet. Tablets that have been prepared were evaluated for the tablet's physical characterization, powder flow

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Franc, Aleš, Slavomir Kurhajec, Sylvie Pavloková, Dana Sabadková, and Jan Muselík. "Influence of concentration and type of microcrystalline cellulose on the physical properties of tablets containing Cornelian cherry fruits." Acta Pharmaceutica 67, no. 2 (2017): 187–202. http://dx.doi.org/10.1515/acph-2017-0019.

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AbstractThe aim of this study was to find the optimal tablet composition with maximum content of dried fruits (Cornus mas L.). The effect of three different concentrations (12.5, 25 and 50 %) of two types of microcrystalline cellulose (Avicel®PH 101 and Avicel®PH 200) and three different compression pressures (20, 60 and 100 MPa) on the physical properties of tablet blends and tablets was studied. Tablets containing 50 % Avicel®PH 101 compressed under 100 MPa were found to have the best physical properties. This combination of composition and compression pressure resulted in stable tablets eve

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Alhamdany, Anas T., and Ali Khidher Abbas. "FORMULATION AND IN VITRO EVALUATION OF AMLODIPINE GASTRORETENTIVE FLOATING TABLETS USING A COMBINATION OF HYDROPHILIC AND HYDROPHOBIC POLYMERS." International Journal of Applied Pharmaceutics 10, no. 6 (2018): 119. http://dx.doi.org/10.22159/ijap.2018v10i6.28687.

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Objective: The aim of this study was to formulate a developed floating tablet of amlodipine using different concentrations and types of hydrophilic and hydrophobic polymers to be conserved in the stomach for modulating solubility and bioavailability, diminishes drug waste and decline side effects.Methods: Through this study, eleven innovative formulations of amlodipine floating tablets were prepared [mixture of amlodipine, sodium bicarbonate (NaHCO3), hydroxypropyl methylcellulose (HPMC) E50, HPMC K100M, ethylcellulose (EC) 5 mp. a. s.] by direct compression method. The pre-compressed mixtures

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Abidin, Ismin Zainol, Emanuele Rezoagli, Bianca Simonassi-Paiva, et al. "A Bilayer Vaginal Tablet for the Localized Delivery of Disulfiram and 5-Fluorouracil to the Cervix." Pharmaceutics 12, no. 12 (2020): 1185. http://dx.doi.org/10.3390/pharmaceutics12121185.

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This study was performed to develop an adjuvant therapy in the form of a self-administered vaginal tablet regimen for the localized delivery of chemotherapeutic drugs. This therapy will help to reduce relapse by eradicating cancerous cells in the margin of cervical tumors. The vaginal tablet is a very common formulation that is easy to manufacture, easy to place in the vagina, and has a low cost of manufacture, making them ideal for use in developing countries. A combination of disulfiram and 5-fluorouracil, which are both off-patent drugs and provide different modes of action, were evaluated.

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Chandan, Singh* Rita Saini Shivanand Patil. "A Review of Bilayer Tablet Technology Immediate and Extended-Release Drug Delivery." International Journal of Pharmaceutical Sciences 3, no. 5 (2025): 4491–503. https://doi.org/10.5281/zenodo.15534239.

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Compared to monotherapy (traditional dosage forms), combination therapy is more common and has several benefits.  The best and most recent example of mixed dose formulation is bilayer tablet technology. The pharmaceutical industry has seen a rise in single-dose formulation that combines 2 or 3 molecules within the tablets. By lowering the number of dosages and increasing the bioavailability of dosage forms, it is well known for encouraging patient convenience and compliance.  Innovative variations of traditional oral drug delivery technologies are bilayer or multilayer tablets. The o

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Masih, Ashish, and Ajay Kumar Tiwari. "FORMULATION AND EVALUATION OF FAST DISSOLVING TABLETS OF AMOXYCILLIN TRIHYDRATE AND POTASSIUM CLAVULANATE." International Journal of Current Pharmaceutical Research 9, no. 2 (2017): 48. http://dx.doi.org/10.22159/ijcpr.2017v9i2.17385.

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Objective: The present work is aimed to formulate fast dissolving stable tablet formulation a preferred combination of Amoxycillin trihydrate (Beta-lactum antibiotic) and Potassium clavulanate (Beta-lactum inhibitor) by using various super disintegrants.Methods: Fast dissolving tablets are prepared by direct compression method using super disintegrants i.e. sodium starch glycolate, crospovidone, croscarmellose sodium. Aspartame as a sweetener and trusil mango flavor were used to increase palatability. Reduction in the dose of Amoxycillin trihydrate and Potassium clavulanate tablet was possible

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Gawande, Siddhant, Aditya Ghadge, and Asmita Sakore. "Expression and Evaluation of Polyherbal Tablet." International Journal of Pharmaceutical Research and Applications 09, no. 06 (2024): 797–803. https://doi.org/10.35629/4494-0906797803.

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Herbal tablet expression dates back to ancient civilisations, where traditional knowledge and natural resources were employed to create effective remedies. They used a combination of powdered plant substance, natural binders and manual compression techniques to formulate the tablets. Historical records from regions similar as India, China, and the Mediterranean reveal different approaches to herbal tablet preparation. Herbal tablet surfaced as a safe, effective, and accessible substitute to synthetic medicine. This study focuses on the expression and evaluation of a herbal tablet prepared usin

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Dr., N. Sandeepthi *and Dr. L. Satyanarayana. "FORMULATION AND EVALUATION OF NAPROXEN SUSTAINED RELEASE MATRIX TABLET." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES 05, no. 03 (2018): 1498–510. https://doi.org/10.5281/zenodo.1204477.

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The present investigation is concerned with development and evaluation of Sustained release matrix tablets containing Naproxen using the hydrophilic polymer hydroxy propyl methyl cellulose (HPMC K100M & HPMC K4M).Preformulation study was done initially which include characterization of polymers, drug identification, FTIR compatibility and result directed for the further course of formulation. The tablets were prepared by direct compression method and evaluation done. Tablets were compressed by tablet compression machine (Karnavati Rimek Mini press1)and evaluated with different parameters l

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M T, Ranjitha, and C. N. Somashekhar. "PREPARATION AND EVALUATION OF MEFENAMIC ACID AND DICYCLOMINE HYDROCHLORIDE AS ORAL DISINTEGRATING TABLET BY DIRECT COMPRESSION METHOD." Journal of Pharmaceutical and Scientific Innovation 10, no. 4 (2021): 94–101. http://dx.doi.org/10.7897/2277-4572.104211.

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A new dosage form, Oral disintegrating tablets (ODT’s) as a replacement to conventional oral dosage forms. ODT’s are dosage forms they disintegrate in mouth offering various advantages such as better mouth feel, dose accuracy, improved stability and convenient dosing as compared to oral liquids. So, there is need to designed oral disintegrating tablet to release the medicaments with an enhanced rate. Mefenamic acid is an anti- inflammatory drug while Dicyclomine HCl is anti-cholinergic drug. The combination of Mefenamic acid & Dicyclomine HCl controls pain very effectively, also relaxes bo

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Gandhi, Kunjan, Sunil Kumar Shah, C. K. Tyagi, Prabhakar Budholiya, and Harish Pandey. "Formulation, Development and Evaluation of Uncoated Bilayer Tablet of Anti-Hypertensive Agents." Journal of Drug Delivery and Therapeutics 10, no. 4-s (2020): 100–107. http://dx.doi.org/10.22270/jddt.v10i4-s.4229.

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The present research work was carried out to Formulate and evaluation of bilayer tablet dosage form for the treatment of Hypertension.The objective of this study to compare the specific characteristics of Metoprolol [beta selective (cardio selective) adrenoreceptor blocking agent] and Hydrochlorothiazide (Thiazide Diuretics]) in order to design stable formulation. It can be concluded that bilayer tablet were successfully formulated to achieve immediate release of Hydrochlorothiazide (HCTZ) and tailored release of Metoprolol (MPL)by using Dual Release Drug Absorption System(DUREDAS technology).

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Soni, Nikita, Deepak Joshi, Vikas Jain, and Pradeep Pal. "A Review on Applications of Bilayer Tablet Technology for Drug Combinations." Journal of Drug Delivery and Therapeutics 12, no. 1 (2022): 222–27. http://dx.doi.org/10.22270/jddt.v12i1.5206.

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Bilayer tablets are novel drug delivery systems where combination of two drugs in a single unit having different release profiles can be delivered. Bilayer tablets improve patient compliance, prolong the drug(s) action and can deliver two incompatible drugs in a single formulation. Bilayer tablets have one layer of active ingredient for immediate release and a second layer for delayed release, either as a second dose or in an extended release fashion. Bilayer tablets are advancing helpful technologies to overcome the disadvantages of single-layered tablets. However, bilayer tablet technology i

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Huynh, Duyen Thi My, Huynh Thien Hai, Tran Huu Loc, Minh-Ngoc T Le, and Phuoc-Vinh Nguyen. "Formulation Optimization and Preparation of Amlodipine and Telmisartan Double-layer Tablets (5/40Mg) using Wet Granulation Method." INTERNATIONAL JOURNAL OF DRUG DELIVERY TECHNOLOGY 14, no. 02 (2024): 810–26. http://dx.doi.org/10.25258/ijddt.14.2.32.

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The two-layer tablet of amlodipine and telmisartan is an effective strategy to manage hypertension disease through a combination of various treatment mechanisms. However, the spray-drying method is currently used to prepare telmisartan tablets due to its extremely low solubility, which requires sophisticated equipment. In this study, wet granulation was applied to fabricate this two-layer tablet. Furthermore, design of experiments were deployed to design and optimize the formulation in order to obtain an in-vitro equivalence with the reference drug. As a result, a formulation of the two-layer

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