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Artykuły w czasopismach na temat „Compound enumeration”

Autor: Grafiati

Data publikacji: 7 grudnia 2024

Data aktualizacji: 19 lipca 2025

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1

Dagar, Komal, Shankar Gupta, Alamjot Singh та Vivek Asati. "In silico studies for the identification of potential thiazolidine-2,4-diones as α-amylase inhibitors". Pharmaspire 15, № 01 (2023): 48–53. http://dx.doi.org/10.56933/pharmaspire.2023.15109.

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Type 2 diabetes, which is characterized by hyperglycemia, is a chronic endocrine metabolic condition. α-amylase inhibitors may have a major therapeutic impact in type 2 diabetic mellitus. In the present study, virtual screening database preparation by R-group enumeration, virtual screening, docking study, and pharmacokinetics analysis was performed by taking α-amylase as a target. The results highlight the important binding features of novel thiazolidine-2,4-dione compounds as α-amylase inhibitors. An R-group enumeration study was performed for the generation of novel thiazolidine-2,4-dione de

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Osaka, Ichie, Jeffrey M. Hills, Sarah L. Kieweg, Heather E. Shinogle, David S. Moore, and P. Scott Hefty. "An Automated Image-Based Method for Rapid Analysis of Chlamydia Infection as a Tool for Screening Antichlamydial Agents." Antimicrobial Agents and Chemotherapy 56, no. 8 (2012): 4184–88. http://dx.doi.org/10.1128/aac.00427-12.

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ABSTRACTA major limitation in the identification of novel antichlamydial compounds is the paucity of effective methods for large-scale compound screening. The immunofluorescence assay is the preferred approach for accurate quantification of the intracellular growth ofChlamydia. In this study, an immunofluorescence image-based method (termed image-based automated chlamydial identification and enumeration [iBAChIE]) was customized for fully automated quantification ofChlamydiainfection using the freely available open-source image analysis software program CellProfiler and the complementary data

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Silverstein, J., T. F. Hess, N. Al Mutaari, and R. Brown. "Enumeration of Toxic Compound Degrading Bacteria in a Multi-Species Activated Sludge Biomass." Water Science and Technology 29, no. 7 (1994): 309–16. http://dx.doi.org/10.2166/wst.1994.0357.

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A most probable number (MPN) method has been described for the enumeration of bacteria responsible for 2,4-dinitrophenol (DNP) degradation in activated sludge cultures. Because of the encapsulation of cells within the activated sludge floc, the method of pretreatment may be critical for producing a homogeneous distribution of bacteria to insure accurate dilution and enumeration. In these experiments, pretreatments using mechanical shear and incubation of cultures in EDTA have been tested. The combination of mechanical shearing in a high speed blender and incubation in a 0.5% EDTA solution resu

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Smith, Bryan J. K., Melissa A. Boothe, Brice A. Fiddler, Tania M. Lozano, Russel K. Rahi, and Mark J. Krzmarzick. "Enumeration of Organohalide Respirers in Municipal Wastewater Anaerobic Digesters." Microbiology Insights 8s2 (January 2015): MBI.S31445. http://dx.doi.org/10.4137/mbi.s31445.

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Organohalide contaminants such as triclosan and triclocarban have been well documented in municipal wastewater treatment plants (WWTPs), but the degradation of these contaminants is not well understood. One possible removal mechanism is organohalide respiration by which bacteria reduce the halogenated compound. The purpose of this study was to determine the abundance of organohalide-respiring bacteria in eight WWTP anaerobic digesters. The obligate organohalide respiring Dehalococcoides mccartyi was the most abundant and averaged 3.3 × 107 copies of 16S rRNA genes per gram, while the Dehalobac

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Feuston, Bradley, Subhas Chakravorty, John Conway, et al. "Web Enabling Technology for the Design, Enumeration, Optimization and Tracking of Compound Libraries." Current Topics in Medicinal Chemistry 5, no. 8 (2005): 773–83. http://dx.doi.org/10.2174/1568026054637656.

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Mat Ripen, Adiratna, Hamidah Ghani, Chai Teng Chear, et al. "Whole exome sequencing identifies compound heterozygous variants of CR2 gene in monozygotic twin patients with common variable immunodeficiency." SAGE Open Medicine 8 (January 2020): 205031212092265. http://dx.doi.org/10.1177/2050312120922652.

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Objectives: A pair of female Malay monozygotic twins who presented with recurrent upper respiratory tract infections, hepatosplenomegaly, bronchiectasis and bicytopenia were recruited in this study. Both patients were suspected with primary immunodeficiency diseases. However, the definite diagnosis was not clear due to complex disease phenotypes. The objective of this study was to identify the causative gene mutation in these patients. Methods: Lymphocyte subset enumeration test and whole exome sequencing were performed. Results: We identified a compound heterozygous CR2 mutation (c.1916G>A

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Hamdy, Rania, Bahgat Fayed, Ahmed Mostafa, et al. "Iterated Virtual Screening-Assisted Antiviral and Enzyme Inhibition Assays Reveal the Discovery of Novel Promising Anti-SARS-CoV-2 with Dual Activity." International Journal of Molecular Sciences 22, no. 16 (2021): 9057. http://dx.doi.org/10.3390/ijms22169057.

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Unfortunately, COVID-19 is still a threat to humankind and has a dramatic impact on human health, social life, the world economy, and food security. With the limited number of suggested therapies under clinical trials, the discovery of novel therapeutic agents is essential. Here, a previously identified anti-SARS-CoV-2 compound named Compound 13 (1,2,5-Oxadiazole-3-carboximidic acid, 4,4′-(methylenediimino) bis,bis[[(2-hydroxyphenyl)methylene]hydrazide) was subjected to an iterated virtual screening against SARS-CoV-2 Mpro using a combination of Ligand Designer and PathFinder. PathFinder, a co

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Osaka, Ichie, and P. Scott Hefty. "Simple Resazurin-Based Microplate Assay for Measuring Chlamydia Infections." Antimicrobial Agents and Chemotherapy 57, no. 6 (2013): 2838–40. http://dx.doi.org/10.1128/aac.00056-13.

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ABSTRACTThe conventional method for quantification ofChlamydiainfection using fluorescence microscopy typically involves time- and labor-intensive manual enumeration, which is not applicable for a large-scale analysis required for an inhibitory compound screen. In this study, an alamarBlue (resazurin) assay was adopted to measureChlamydiainfection by measuring the redox capability of infected host cells in a 96-well format. The assay provided measurements comparable to those of the conventional microscopy method while drastically reducing the time required for analysis.

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Stachelska, Milena Alicja, Adam Ekielski, Piotr Karpiński, Tomasz Żelaziński, and Bartosz Kruszewski. "New Genetic Determinants for qPCR Identification and the Enumeration of Selected Lactic Acid Bacteria in Raw-Milk Cheese." Molecules 29, no. 7 (2024): 1533. http://dx.doi.org/10.3390/molecules29071533.

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Lactic acid bacteria (LAB) play an important role in the ripening of cheeses and contribute to the development of the desired profile of aroma and flavor compounds. Therefore, it is very important to monitor the dynamics of bacterial proliferation in order to obtain an accurate and reliable number of their cells at each stage of cheese ripening. This work aimed to identify and conduct a quantitative assessment of the selected species of autochthonous lactic acid bacteria from raw cow’s milk cheese by the development of primers and probe pairs based on the uniqueness of the genetic determinants

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Meringer, Markus, and H. James Cleaves. "Exploring astrobiology using in silico molecular structure generation." Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences 375, no. 2109 (2017): 20160344. http://dx.doi.org/10.1098/rsta.2016.0344.

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The origin of life is typically understood as a transition from inanimate or disorganized matter to self-organized, ‘animate’ matter. This transition probably took place largely in the context of organic compounds, and most approaches, to date, have focused on using the organic chemical composition of modern organisms as the main guide for understanding this process. However, it has gradually come to be appreciated that biochemistry, as we know it, occupies a minute volume of the possible organic ‘chemical space’. As the majority of abiotic syntheses appear to make a large set of compounds not

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Vieira, Vítor, Paulo Maia, Miguel Rocha, and Isabel Rocha. "Comparison of pathway analysis and constraint-based methods for cell factory design." BMC Bioinformatics 20, no. 1 (2019): 350. https://doi.org/10.1186/s12859-019-2934-y.

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<strong>Background: </strong>Computational strain optimisation methods (CSOMs) have been successfully used to exploit genome-scale metabolic models, yielding strategies useful for allowing compound overproduction in metabolic cell factories. Minimal cut sets are particularly interesting since their definition allows searching for intervention strategies that impose strong growth-coupling phenotypes, and are not subject to optimality bias when compared with simulation-based CSOMs. However, since both types of methods have different underlying principles, they also imply different ways to formul

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Ley, Arthur Newton, Raymond John Bowers та Saul Wolfe. "Indoxyl-β-D-glucuronide, a novel chromogenic reagent for the specific detection and enumeration of Escherichia coli in environmental samples". Canadian Journal of Microbiology 34, № 5 (1988): 690–93. http://dx.doi.org/10.1139/m88-115.

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About 97% of Escherichia coli strains produce β-glucuronidase, but almost all other Enterobacteriaceae lack this enzyme. A D-glucopyranosiduronic acid (glucuronide) possessing a readily detectable β-linked aglycone should, therefore, constitute a specific reagent for the detection of this organism. For this purpose, the title compound has been synthesized for the first time. The synthesis proceeds in eight steps from readily available D-glucuronolactone, anthranilic acid, and chloroacetic acid and can be carried out on a large scale. The compound has the predicted properties: when included in

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Osmulski, Pawel A., Jodie Cropper, Matt Giletto, et al. "Anticancer applications of allosteric inhibitors of proteasome." Journal of Clinical Oncology 35, no. 15_suppl (2017): e23066-e23066. http://dx.doi.org/10.1200/jco.2017.35.15_suppl.e23066.

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e23066 Background: Proteasome as a hub protease of the ubiquitin proteasome pathway is an established anticancer drug target. Several drugs that inhibit proteasome are currently used to successfully treat aggressive blood cancers. These drugs are based on their competition with protein substrates of proteasome. However, efficacy of these drugs toward solid cancers is inadequate. Besides, the side effects and developing drug resistance are increasingly hampering the therapy. Therefore, there is an unmet challenge to develop new types of proteasome targeting compounds that are efficient against

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Bjerrum, Esben, and Boris Sattarov. "Improving Chemical Autoencoder Latent Space and Molecular De Novo Generation Diversity with Heteroencoders." Biomolecules 8, no. 4 (2018): 131. http://dx.doi.org/10.3390/biom8040131.

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Chemical autoencoders are attractive models as they combine chemical space navigation with possibilities for de novo molecule generation in areas of interest. This enables them to produce focused chemical libraries around a single lead compound for employment early in a drug discovery project. Here, it is shown that the choice of chemical representation, such as strings from the simplified molecular-input line-entry system (SMILES), has a large influence on the properties of the latent space. It is further explored to what extent translating between different chemical representations influence

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Abedini, Amin, Marius Colin, Jane Hubert, et al. "Abundant Extractable Metabolites from Temperate Tree Barks: The Specific Antimicrobial Activity of Prunus Avium Extracts." Antibiotics 9, no. 3 (2020): 111. http://dx.doi.org/10.3390/antibiotics9030111.

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Tree barks are mainly considered as wood wastes from forestry activities, but represent valuable resources as they may contain antimicrobial compounds. Here, we aimed to evaluate the possible antimicrobial activities of bark extracts and to characterize the chemical composition of the most active extract. Ten methanol bark extracts were tested in vitro against 17 bacterial strains and 5 yeast strains, through minimum inhibitory concentration (MIC) and minimum bactericidal (or fungicidal) concentration (MBC/MFC) assays. The extract from Prunus avium (E2-4) displayed the largest bactericidal act

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Gherbawy, Youssuf A., Karima E. Abdel Fattah, Abdullah Altalhi, Pet Ioan, and Mohamed A. Hussein. "Detection of Mycotoxins and Aflatoxigenic Fungi Associated with Compound Poultry Feedstuffs in Saudi Arabia." Microbiology Research 16, no. 1 (2025): 11. https://doi.org/10.3390/microbiolres16010011.

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Poultry feeds with cereal grain-based constituents are vulnerable to fungal contamination during the processing and storage stages. A total of 100 samples of compound poultry feedstuffs were collected from the cities of Riyadh, Alhassa, Qassim, and Jeddah in Saudi Arabia. A quantitative enumeration of fungal colony-forming units (CFUs) was performed on Dichloran Rose Bengal Chloramphenicol Agar (DRBC) and Czapek Iprodione Dichloran Agar (CZID) media. Aspergillus flavus was the most predominant species, accounting for 18.714 × 103 and 3.956 × 103 CFU/g, with frequencies of 84 and 42% in the fee

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Edwall, Christy. "Clare's Poetic Binomials." Romanticism 26, no. 2 (2020): 116–27. http://dx.doi.org/10.3366/rom.2020.0458.

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John Clare's confessed preference for the ‘vulgar’ names of flowers and his apparent dismissal of the sexual system as ‘darkness visible’ seems to keeps the taint of Linnaean influence at a distance. His enumeration of flowers in ‘The Wild Flower Nosgay’, however, looks very much like two eighteenth-century descriptive procedures: poetic diction and binomial nomenclature. Dryden's popular translation of Virgil's Georgics modified a classical inheritance of compound epithets into phrases later recognised as poetic diction. This inheritance finds an unexpected consonance in the binomial nomencla

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YEWALE, SADANAND, ZEBA FARASH, SANMAN KOLHE, et al. "Benefits of Soleris® over the Conventional Method for Enumeration of Microbial Load in Salacia Herbal Extract." Polish Journal of Microbiology 69, no. 4 (2020): 453–62. http://dx.doi.org/10.33073/pjm-2020-048.

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Stems and roots of Salacia genus plants have been used as a specific remedy for early-stage diabetes, and one of the four sulphonium sulphates, salacinol is the compound responsible for the anti-diabetic activity. Salacia is prone to microbial contamination and insect infestation; hence, methods to estimate the microbial load in such plants will enhance its nutritional value. This paper highlights the novel use of Soleris® to quantify microbes of all types, namely bacteria, yeasts, molds, and coliforms in herbal extracts. The microbial analysis results obtained with Soleris® test vial have bee

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Lyons, E. T., J. H. Drudge та S. C. Tolliver. "Controlled test of anthelmintic activity of a macrocyclic lactone (compound F28249-α) in lambs". American Journal of Veterinary Research 50, № 6 (1989): 975–77. https://doi.org/10.2460/ajvr.1989.50.06.975.

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SUMMARY A controlled blind test was performed in 1984 to evaluate the anthelmintic activity of experimental formulations of compound F28249-α against gastrointestinal parasites in lambs in Kentucky. Twenty-five lambs were allotted to 5 groups of 5 lambs/group. The drug was administered sc to 2 groups (A, 0.2 mg/ kg of body weight; B, 0.3 mg/kg) and orally to 2 groups (C, 0.2 mg/kg; D, 0.3 mg/kg). Group E received a placebo subcutaneously. Lambs were euthanatized 7 days after treatment for necropsy and identification and enumeration of worm parasites in the gastrointestinal tract. Group-E lambs

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Wagle, B. R., K. Arsi, A. Upadhyay та ін. "β-Resorcylic Acid, a Phytophenolic Compound, Reduces Campylobacter jejuni in Postharvest Poultry". Journal of Food Protection 80, № 8 (2017): 1243–51. http://dx.doi.org/10.4315/0362-028x.jfp-16-475.

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ABSTRACTHuman Campylobacter infections, a leading foodborne illness globally, has been linked with the high prevalence of this bacterium on raw retail chicken products. Reduction of Campylobacter counts on poultry products would greatly reduce the risk of subsequent infections in humans. To this end, this study investigated the potential of the phytophenolic compound β-resorcylic acid (BR) to reduce Campylobacter counts on postharvest poultry (chicken skin or meat). Four trials in total, two each on thigh skin or breast meat, were conducted in which chicken skin or meat samples (2 ± 0.1 g; 10

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Bhattacharyya, L. H., Gayatree Borah, Vipin Parkash, and P. N. Bhattacharyya. "Fungal endophytes associated with the ethnomedicinal plant Meyna spinosa Roxb." Current Life Sciences 3, no. 1 (2017): 1–5. https://doi.org/10.5281/zenodo.258104.

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Endophytes are a group of microorganism that grow within the tissues of higher plants and colonize them without causing any noticeable injury to the host. Both bacteria and fungi are considered as endophytes. As endophytes represent a potential hub of novel bioactive compounds such as antibiotics, anticancer and other biological control agents, scientific investigations to explore the diversity of endophytic microbes seemed to be significant. <em>Meyna spinosa Roxb</em>. belongs to the family Rubiaceae (local name: <em>Kutkura</em>) is a medium sized tree with potent medicinal properties. Alto

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Mangal, Anupam K., Chinmay Rath, Selim Mehmud, et al. "Medico-ethnobotanical Claims used against Gastrointestinal Disorders by Different Tribes of Assam, India." Journal of Drug Research in Ayurvedic Sciences 2, no. 3 (2017): 175–82. http://dx.doi.org/10.5005/jp-journals-10059-0017.

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ABSTRACT Aim The present communication deals with some newly reported Medico-ethnobotanical claims used for the treatment of various gastrointestinal disorders like blood dysentery, chronic dysentery, diarrhea, and cholera by using medicinal plants documented during field survey since last 3 years. Materials and methods Field surveys were conducted in different locations of Assam where many folk healers were interviewed for documentation of Medico-ethnobotanical information. The reported plants are collected, identified, and specimens are preserved. Results Nine different tribes and communitie

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Sipiczki, Bojána. "Studies on the Suitability of Different Mould Media Compositions for the Mycological Evaluation of Hay Samples." Acta Agraria Debreceniensis, no. 10 (May 11, 2003): 34–38. http://dx.doi.org/10.34101/actaagrar/10/3459.

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t evaluating mould contamination of hay samples in more than the half of the cases Mucor spp. (and Trichoderma spp. in a smaller extent) overgrew slower developing moulds, spoiling the assessment of total mould CFU and the detection of fastidious organisms, among others the toxinogenic Fusaria. In parallel microbiological evaluation of hay samples comparing to the ISO 7954 medium as reference a) the overgrowth inhibiting effect of Rose Bengal (ISO 7954-RB); b) the combined inhibiting effect of Rose Bengal and Dichloran (dichloro-mononitroaniline) in DRBC; c) the inhibition of Dichlorane in ISO

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Reindel, J. F., C. M. Hoorn, J. G. Wagner, and R. A. Roth. "Comparison of response of bovine and porcine pulmonary arterial endothelial cells to monocrotaline pyrrole." American Journal of Physiology-Lung Cellular and Molecular Physiology 261, no. 6 (1991): L406—L414. http://dx.doi.org/10.1152/ajplung.1991.261.6.l406.

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Monocrotaline (MCT)-induced vascular injury in liver and lung may be caused by interaction of MCT metabolites such as monocrotaline pyrrole (MCTP) with vascular cells. Responses of bovine and porcine pulmonary artery endothelial cells (BECs and PECs, respectively) to a single administration of MCTP were compared. MCTP caused a delayed and progressive release of lactate dehydrogenase (LDH) activity from BECs and a gradual decrease in monolayer cellularity. Surviving cells became markedly hypertrophic. PECs were less sensitive to the cytolytic effects of MCTP, showing minimal cell detachment and

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Ushiyama, Masashi, and Mihoko Iwasaki. "Evaluation of Sanita-kun E. coli & Coliform Sheet Medium for the Enumeration of Total Coliforms and E. coli." Journal of AOAC INTERNATIONAL 93, no. 1 (2010): 163–83. http://dx.doi.org/10.1093/jaoac/93.1.163.

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Abstract The Sanita-kun E. coli & Coliform sheet medium consists of a transparent cover film, an adhesive sheet, a layer of nonwoven fabric, and a water-soluble compound film, including a culture medium formula for the enumeration of total coliforms and differentiation of Escherichia coli. The Sanita-kun E. coli & Coliform sheet is a chromogenic medium and contains X-Gal, which is hydrolyzed by β-galactosidase from coliforms to produce a visible blue dye and Salmon-glucuronic acid, which is hydrolyzed by β-glucuronidase from E. coli to produce a red-purple dye. It is easy to distinguis

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Venkatraman, Vishwesh, Jeremiah Gaiser, Daphne Demekas, Amitava Roy, Rui Xiong, and Travis J. Wheeler. "Do Molecular Fingerprints Identify Diverse Active Drugs in Large-Scale Virtual Screening? (No)." Pharmaceuticals 17, no. 8 (2024): 992. http://dx.doi.org/10.3390/ph17080992.

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Computational approaches for small-molecule drug discovery now regularly scale to the consideration of libraries containing billions of candidate small molecules. One promising approach to increased the speed of evaluating billion-molecule libraries is to develop succinct representations of each molecule that enable the rapid identification of molecules with similar properties. Molecular fingerprints are thought to provide a mechanism for producing such representations. Here, we explore the utility of commonly used fingerprints in the context of predicting similar molecular activity. We show t

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Cluff, Christopher W., Jory R. Baldridge, Axel G. Stöver, et al. "Synthetic Toll-Like Receptor 4 Agonists Stimulate Innate Resistance to Infectious Challenge." Infection and Immunity 73, no. 5 (2005): 3044–52. http://dx.doi.org/10.1128/iai.73.5.3044-3052.2005.

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ABSTRACT A compound family of synthetic lipid A mimetics (termed the aminoalkyl glucosaminide phosphates [AGPs]) was evaluated in murine infectious disease models of protection against challenge with Listeria monocytogenes and influenza virus. For the Listeria model, intravenous administration of AGPs was followed by intravenous bacterial challenge 24 h later. Spleens were harvested 2 days postchallenge for the enumeration of CFU. For the influenza virus model, mice were challenged with virus via the intranasal/intrapulmonary route 48 h after intranasal/intrapulmonary administration of AGPs. T

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Novak, Igor. "Isonumeric Compounds: Derivative Enumeration." Zeitschrift für Naturforschung A 49, no. 7-8 (1994): 790–92. http://dx.doi.org/10.1515/zna-1994-7-810.

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Granados-Chinchilla, Fabio, Carol Valenzuela-Martínez, Berny García-Murillo, David Aguilar-Madrigal, Mauricio Redondo-Solano, and Andrea Molina. "Microbiological Safety and Presence of Major Mycotoxins in Animal Feed for Laboratory Animals in a Developing Country: The Case of Costa Rica." Animals 11, no. 8 (2021): 2389. http://dx.doi.org/10.3390/ani11082389.

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Safety and quality of compound feed for experimental animals in Costa Rica is unknown. Some contaminants, such as Salmonella spp. and mycotoxins, could elicit confounding effects in laboratory animals used for biomedical research. In this study, different batches of extruded animal feed, intended for laboratory rodents in Costa Rica, were analyzed to determine mycotoxin and microbiological contamination (i.e., Salmonella spp., Escherichia coli, total coliform bacteria, and total yeast and molds enumeration). Two methods for Salmonella decontamination (UV light and thermal treatment) were asses

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Watmough, Gary R., Charlotte L. J. Marcinko, Clare Sullivan, et al. "Socioecologically informed use of remote sensing data to predict rural household poverty." Proceedings of the National Academy of Sciences 116, no. 4 (2019): 1213–18. http://dx.doi.org/10.1073/pnas.1812969116.

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Tracking the progress of the Sustainable Development Goals (SDGs) and targeting interventions requires frequent, up-to-date data on social, economic, and ecosystem conditions. Monitoring socioeconomic targets using household survey data would require census enumeration combined with annual sample surveys on consumption and socioeconomic trends. Such surveys could cost up to $253 billion globally during the lifetime of the SDGs, almost double the global development assistance budget for 2013. We examine the role that satellite data could have in monitoring progress toward reducing poverty in ru

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Toruan, R. L., S. H. Nasution, T. Sukmono, R. Kurniawan, Imroatushshoolikhah, and D. Listyarini. "Zooplankton community structure in Batanghari riverine systems." IOP Conference Series: Earth and Environmental Science 1436, no. 1 (2024): 012004. https://doi.org/10.1088/1755-1315/1436/1/012004.

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Abstract The Batanghari River flows from the province of West Sumatra into the West Coast of Jambi, covering a distance of approximately 870 km. Within the Batanghari watershed, diverse habitats have been recognized, including riverine channels, floodplains and oxbow lakes. These distinct habitats provide unique niches for a highly diverse aquatic biota, including zooplankton. This study focused on investigating the zooplankton community structures within the Batanghari riverine systems. The research employed a snapshot sampling methodology, in which each sampling station was visited and sampl

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Pizon, Monika, Dorothea Zimon, Ulrich A. Pachmann, and Katharina Pachmann. "In vitro chemosensitivity testing of mammospheres cultured from circulating epithelial tumor cells (CETCs) of breast cancer patients: Comparision to chemosensitivity of total CETCs." Journal of Clinical Oncology 32, no. 26_suppl (2014): 50. http://dx.doi.org/10.1200/jco.2014.32.26_suppl.50.

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50 Background: In vitro chemosensitivity testing of circulating epithelial tumor cells (CETCs) provides real-time information about the sensitivity of the tumor cells present in the patient. Nevertheless, a fraction of CETCs can survive after conventional chemotherapy and grow into distant metastasis. This may be a subpopulation of CETCs with proliferation activity which has the ability to form floating spheres in suspension culture. Spheroids exhibit stem cell-like properties and may be responsible for chemotherapeutic resistance. Therefore, the aim of our study was to determine the efficacy

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Tagle, Darra Maida. "The Effectiveness of the Creative Mathematical Problem-Solving Practices in Improving the Performance in General Mathematics of the Grade 11 Learners in Calauag West District, Division of Quezon." Psychology and Education: A Multidisciplinary Journal 29, no. 10 (2024): 1595–616. https://doi.org/10.5281/zenodo.14580053.

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This study assessed the effectiveness of creative mathematical problem-solving practices in enhancing the performance of Grade 11 learners in General Mathematics in the Calauag West District, Division of Quezon, for the School Year 2023–2024. It examined the level of creative problem-solving practices in terms of flexibility, fluency, originality, and elaboration, and evaluated their impact on performance in topics such as logarithmic functions, simple and compound interest, functions and their graphs, and basic business mathematics. The study also explored significant agreements in the

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Henderson-Walshe, George, Michael Langton, Jeanette McLeod, and Phillip Wilson. "Algebraic Enumeration of Polypolyhedra." PUMP Journal of Undergraduate Research 7 (October 20, 2024): 207–30. http://dx.doi.org/10.46787/pump.v7i0.3936.

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Polypolyhedra are edge-transitive compounds of polyhedra. In this paper we use group theory to determine the number of distinct polypolyhedra whose symmetry group is any given finite irreducible Coxeter group. We apply this result in order to enumerate the 3-dimensional polypolyhedra.

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Bentley, Victoria L., Chansey J. Veinotte, Dale Corkery, et al. "Zebrafish Xenotransplantation and Focused Chemical Genomics: A Preclinical Therapeutic Model For T-Cell Acute Lymphoblastic Leukemia." Blood 122, no. 21 (2013): 2670. http://dx.doi.org/10.1182/blood.v122.21.2670.2670.

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Abstract T-cell acute lymphoblastic leukemia (T-ALL) is a high-risk subset of ALL, for which there is a need for new therapeutic strategies and efficient preclinical screening methods. We have pioneered an innovative zebrafish human cancer xenotransplantation (XT) model to examine drug-tumor interactions in vivo. T-ALL cell lines and primary patient T-ALL samples were microinjected into 48-hour zebrafish embryos, a stage at which the adaptive immune system has not yet developed. Fluorescent labelling of tumor cells prior to injection and use of casper pigment mutant fish facilitates evaluation

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ZHAO, YANG, MORIHIRO HAYASHIDA, JIRA JINDALERTUDOMDEE, HIROSHI NAGAMOCHI, and TATSUYA AKUTSU. "BREADTH-FIRST SEARCH APPROACH TO ENUMERATION OF TREE-LIKE CHEMICAL COMPOUNDS." Journal of Bioinformatics and Computational Biology 11, no. 06 (2013): 1343007. http://dx.doi.org/10.1142/s0219720013430075.

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Molecular enumeration plays a basic role in the design of drugs, which has been studied by mathematicians, computer scientists, and chemists for quite a long time. Although many researchers are involved in developing enumeration algorithms specific to drug design systems, molecular enumeration is still a hard problem to date due to its exponentially increasing large search space with larger number of atoms. To alleviate this defect, we propose efficient algorithms, BfsSimEnum and BfsMulEnum to enumerate tree-like molecules without and with multiple bonds, respectively, where chemical compounds

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Merris, Russell, G. Polya, and R. C. Read. "Combinatorial Enumeration of Groups, Graphs, and Chemical Compounds." American Mathematical Monthly 96, no. 3 (1989): 269. http://dx.doi.org/10.2307/2325230.

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Anderson, I., G. Polya, and R. C. Read. "Combinatorial Enumeration of Groups, Graphs and Chemical Compounds." Mathematical Gazette 72, no. 461 (1988): 244. http://dx.doi.org/10.2307/3618278.

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King, R. B., and D. H. Rouvray. "ISOMER ENUMERATION IN POLYTERTIARY PHOSPHINES AND RELATED COMPOUNDS." Phosphorus and Sulfur and the Related Elements 22, no. 2 (1985): 177–82. http://dx.doi.org/10.1080/03086648508073445.

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Kvasnička, Vladimír, and Jiří Pospíchal. "Constructive enumeration of acyclic molecules." Collection of Czechoslovak Chemical Communications 56, no. 9 (1991): 1777–802. http://dx.doi.org/10.1135/cccc19911777.

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Simple combinatorial theory of constructive enumeration of rooted trees and trees is suggested. As a byproduct of this approach very simple recursive formulae for numerical (i.e. nonconstructive) enumeration are obtained. The method may be simply generalized for (rooted) trees with edges evaluated by multiplicities and vertices evaluated by alphabetic – atomic symbols. In the process of constructive enumeration the (rooted) trees are represented by unambiguous linear code composed of valences of vertices, edge multiplicities, and atomic symbols assigned to vertices. The elaborated theory may s

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li, Zhaoang, Chenyu Lin, David J. Bearss, and Hariprasad Vankayalapati. "Abstract 4587: Development of highly selective, potent, orally available PIM1 inhibitor BLX0631 shows a therapeutics potential in multiple myeloma models." Cancer Research 84, no. 6_Supplement (2024): 4587. http://dx.doi.org/10.1158/1538-7445.am2024-4587.

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Abstract Background: The Proto-oncogenic PIMs family are nuclear and cytoplasmic Ser/Thr kinases (PIM1, PIM2, and PIM3) that are constitutively active and play a vital role in proliferation and survival in Multiple Myeloma (MM). Activated PIM1 kinase can induce progression of the cell cycle, inhibition of apoptosis, and modulation of other signal transduction pathways. Methods: BLX-0631 and a few analogs evaluated against a panel of MM cell lines (EJM, IM-9, L-363, LP-1, MM-1R, MM.1S, MOLP-2, NCI-H929, OPM-2, RPMI8226 and U-266) and primary MM patient samples by CellTiter-Glo® (CTG) assays. Ce

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KALCHAYANAND, NORASAK, TERRANCE M. ARTHUR, JOSEPH M. BOSILEVAC, et al. "Efficacy of Antimicrobial Compounds on Surface Decontamination of Seven Shiga Toxin–Producing Escherichia coli and Salmonella Inoculated onto Fresh Beef†." Journal of Food Protection 78, no. 3 (2015): 503–10. http://dx.doi.org/10.4315/0362-028x.jfp-14-268.

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Several antimicrobial compounds have been used in commercial meat processing plants for decontamination of pathogens on beef carcasses, but there are many commercially available, novel antimicrobial compounds that may be more effective and suitable for use in beef processing pathogen-reduction programs. Sixty-four prerigor beef flanks (cutaneous trunci) were used in a study to determine whether hypobromous acid, neutral acidified sodium chlorite, and two citric acid–based antimicrobial compounds effectively reduce seven Shiga toxin–producing Escherichia coli (STEC) serogroups and Salmonella on

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Sood, Raman, Linda Rivera, Jagman Chahal, et al. "Generation of Zebrafish Lines with New Gata1 Mutations and Their Characterization with a Novel In Vitro Colony-Forming Assay." Blood 108, no. 11 (2006): 1336. http://dx.doi.org/10.1182/blood.v108.11.1336.1336.

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Abstract Gata1 is a transcription factor critical for erythroid and megakaryocyte differentiation. We have shown previously that the lethal bloodless phenotype of the zebrafish mutant vlad tepes (vlt) is due to a nonsense mutation in gata1, suggesting that hematopoietic regulation is conserved between zebrafish and mammals. We have now generated fish with 2 novel missense mutations, T301K and K333R, identified by sequencing exons 5 and 6 in 1235 F1 fish derived from ENU-mutagenized males. Both mutations change conserved residues in the C-terminal zinc finger domain of gata1. Embryos homozygous

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Morikawa, Tetsuo. "Graph-Theoretical Enumeration of Conjugated Patterns for Carbocyclic and Heterocyclic Compounds*." Zeitschrift für Naturforschung A 49, no. 3 (1994): 511–14. http://dx.doi.org/10.1515/zna-1994-0310.

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Abstract An algorithmic analysis of the existence of conjugated patterns for carbocyclic and heterocyclic compounds is presented. This graph theoretical method is applicable to the enumeration of Kekulé patterns for hydrocarbon benzenoids, as a special case.

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Chávez-Hernández, Ana L., Johny R. Rodríguez-Pérez, Héctor F. Cortés-Hernández, Hoover A. Valencia-Sanchez, Miguel Á. Chávez-Fumagalli, and José L. Medina-Franco. "Fragment Library of Colombian Natural Products: Generation and Comparative Chemoinformatic Analysis." Drugs and Drug Candidates 3, no. 4 (2024): 736–50. http://dx.doi.org/10.3390/ddc3040042.

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Fragment libraries have a major significance in drug discovery due to their role in de novo design and enumerating large and ultra-large compound libraries. Although several fragment libraries are commercially available, most are derived from synthetic compounds. The number of fragment libraries derived from natural products is still being determined. Still, they represent a rich source of building blocks to generate pseudo-natural products and bioactive synthetic compounds inspired by natural products. In this work, we generated and analyzed a fragment library of natural products from Colombi

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Mesarch, Matthew B., Cindy H. Nakatsu, and Loring Nies. "Development of Catechol 2,3-Dioxygenase-Specific Primers for Monitoring Bioremediation by Competitive Quantitative PCR." Applied and Environmental Microbiology 66, no. 2 (2000): 678–83. http://dx.doi.org/10.1128/aem.66.2.678-683.2000.

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ABSTRACT Benzene, toluene, xylenes, phenol, naphthalene, and biphenyl are among a group of compounds that have at least one reported pathway for biodegradation involving catechol 2,3-dioxygenase enzymes. Thus, detection of the corresponding catechol 2,3-dioxygenase genes can serve as a basis for identifying and quantifying bacteria that have these catabolic abilities. Primers that can successfully amplify a 238-bp catechol 2,3-dioxygenase gene fragment from eight different bacteria are described. The identities of the amplicons were confirmed by hybridization with a 238-bp catechol 2,3-dioxyge

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Tkhagazitov, Yuri M., Takhir Z. Tolgurov, and Fatima T. Uzdenova. "Introverted Spatial Narrative: Azimuths and Linearity." Current Issues in Philology and Pedagogical Linguistics, no. 4 (December 25, 2022): 204–16. http://dx.doi.org/10.29025/2079-6021-2022-4-204-216.

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The article is devoted to the analysis of topological models of L.N. Tolstoy. The goal is to recearch the narrative and suggestive functions of the writer’s individual spatial representations, as well as their role in creating the emotive-evaluative structure of the narrative. The material of the study was the works: “Childhood”, “Foray”, “Master and Worker”, “Resurrection”. In modern literary criticism, there are de facto no studies of the writer’s spatial reflection, which already ensures a high level of relevance of the material presented. The main research methods were comparative, structu

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Shestakov, V. A., and E. V. Grachev. "Enumeration of Melting Diagrams for Four-Component Systems Comprising Stoichiometric Compounds." Russian Journal of Inorganic Chemistry 67, no. 4 (2022): 488–91. http://dx.doi.org/10.1134/s0036023622040179.

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Kosyakov, V. I., V. A. Shestakov, and E. V. Grachev. "Enumeration of melting diagrams of three-component systems with stoichiometric compounds." Russian Journal of Inorganic Chemistry 55, no. 4 (2010): 611–19. http://dx.doi.org/10.1134/s0036023610040194.

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Cole, Jacqueline M. "Enumerating Intramolecular Charge Transfer in Conjugated Organic Compounds." Journal of Chemical Information and Modeling 60, no. 12 (2020): 6095–108. http://dx.doi.org/10.1021/acs.jcim.0c00913.

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