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Artykuły w czasopismach na temat „Control of Biologicals”

Autor: Grafiati

Data publikacji: 3 czerwca 2025

Data aktualizacji: 31 lipca 2025

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1

Serhiienko, V. H., O. I. Borzykh, H. M. Tkalenko, and H. O. Balan. "CONTROL OF WHITE CABBAGE DISEASES USING BIOLOGICALS." Vegetable and Melon Growing, no. 73 (July 27, 2023): 81–88. http://dx.doi.org/10.32717/0131-0062-2023-73-81-88.

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Purpose. To investigate effects of biologicals on disease-induced damage to white cabbage plants during the growing period and on yield. Methods. Informational/analytical (collection and review of publications), field research (planning and conducting experiments, records of plant damage, harvesting and accounting of yields), phytopathological (isolation and identification of pathogens), mathematical/statistical (processing of data). The following biologicals were used in he experiments: Azotobacterin liq. (Azotobacter chroococcum IMV B-7171), Ecophosphorin liq. (Bacillus megaterium IMV B-7168

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Gutiérrez-Benicio, Glenda Margarita, César Leobardo Aguirre-Mancilla, Jesús Manuel Arreola-Tostado, and Gerardo Armando Aguado-Santacruz. "Growth, Health, Quality, and Production of Onions (Allium cepa L.) Inoculated with Systemic Biological Products." Microorganisms 13, no. 4 (2025): 797. https://doi.org/10.3390/microorganisms13040797.

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The efficiency and consistency of biologicals in the field remain a drawback of current conventional products. The development of systemic biological products has opened a new avenue for microbiological and agricultural research. In this study, we evaluated over a two-year period (2022 and 2023) the functioning of two systemic products, a biofertilizer and biofungicide, on the performance of the onion. The first indicator of proper functioning of these products in onions was reflected in increased chlorophyll accumulation. At the end of both years, the inoculated plants were taller, heavier, a

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Berdnikova, Z. E., and A. S. Tikhonova. "Recommendations for the development of sterility testing procedures for biological medicinal products based on pharmacopoeial methods." Biological Products. Prevention, Diagnosis, Treatment 24, no. 2 (2024): 229–36. http://dx.doi.org/10.30895/2221-996x-2024-24-2-229-236.

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INTRODUCTION. The distinctive nature and composition of biological medicinal products present certain challenges for the detection of microbial contamination, which affects the reliability of sterility control results. The main challenges associated with testing biologicals include changes in the appearance and physical properties of culture media or samples, an increased risk of contamination or false-positive results in direct inoculation tests, filtration issues, etc. When drafting product specification files and analytical method validation reports in dossiers for biologicals, manufacturer

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Jeffcoate, S. L., M. J. Corbel, P. D. Minor, R. Gaines-Das, and G. C. Schild. "The control and standardisation of biological medicines." Proceedings of the Royal Society of Edinburgh. Section B. Biological Sciences 101 (1993): 207–26. http://dx.doi.org/10.1017/s0269727000005753.

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SynopsisAssuring the quality, safety and efficacy of the complex medicinal drugs known as ‘biologicals’ has many facets of importance to public health. This survey covers the historical basis of this area of medical science through current issues and practices to the anticipation of future challenges. The key role of the World Health Organization in promoting international biological standardisation and of biostatistics in the design and analysis of biological assays is emphasised. Examples of the importance of quality control and standardisation are drawn especially from the fields of bacteri

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Timoshenko, D. O., K. S. Pavlova, O. M. Kurbacheva, et al. "Impact of biologicals on chronic rhinosinusitis with nasal polyps in combination with severe asthma." PULMONOLOGIYA 33, no. 5 (2023): 600–610. http://dx.doi.org/10.18093/0869-0189-2023-33-5-600-610.

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Chronic rhinosinusitis with nasal polyps (CRSwNP) is often associated with asthma. This combination aggravates the course of both conditions, including the frequency and severity of asthma and CRSwNP exacerbations. Currently, the main strategy in the treatment of severe asthma is the use of biologicals, which may also impact CRSwNP symptoms, considering the similarity of pathogenic mechanisms of these diseases. The aim of our study was to evaluate the impact of biological therapy on CRSwNP in combination with severe asthma. Methods. 49 patients with CRSwNP and severe asthma were included in a

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Halder, Marlies, Michael Balls, Coenraad Hendriksen, and Klaus Cussler. "ECVAM's Activities on Biologicals." Alternatives to Laboratory Animals 30, no. 2_suppl (2002): 125–28. http://dx.doi.org/10.1177/026119290203002s20.

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This paper summarises key activities initiated and the progress achieved between April 1993 and June 2002 in implementing the Three Rs in one of ECVAM's priority areas — the production and quality control of biologicals. These have included: organising nine key workshops; financially supporting and/or participating in a number of prevalidation and/or validation studies; financial contributions and sponsorship to relevant international workshops, symposia and conferences; and financial support for the compilation of manuals and expert reports, and training in test methods. The paper complements

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Cussler, Klaus, Marlies Halder, and Coenraad Hendriksen. "Future Activities: ECVAM and the Quality Control of Biologicals." Alternatives to Laboratory Animals 30, no. 2_suppl (2002): 225–26. http://dx.doi.org/10.1177/026119290203002s38.

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ECVAM's activities in the field of biologicals have contributed in many ways to the successful incorporation of Three Rs methods, as summarised elsewhere in these proceedings. The progress achieved is impressive, but large numbers of animals are still needed in order to meet the requirements stipulated by various regulations. ECVAM's activities in this area should therefore be continued and extended. Besides the well-established organisation of ECVAM workshops and contributions to conferences, further prevalidation and validation studies should be funded. In addition, studies on refinement, an

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Ashok kumar P, Divija P M, Reshma B R, Bhoomika K R, and Ramya Shree R. "Regulatory requirements for approval of biological products as per CDSCO in Indian comparison with South Korea." World Journal of Advanced Research and Reviews 20, no. 1 (2023): 758–67. http://dx.doi.org/10.30574/wjarr.2023.20.1.2079.

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Biologicals are restorative, therapeutic, analytic, preventive, arrangements created or got from living life forms and their turn for human use. Biological products are expected to continue to play a significant role in the future of medicine and health care. They include vaccines, serum, blood and blood products, gene therapy, antibodies, etc. The Indian administrative expert (CDSCO), is the body which is in charge of the advancement and promoting biologics in India. And in South Korea MFDS is responsible for regulations of biologics. Objective: Unveiling the differences in regulatory approva

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Balan, Radu-Gheorghe, Diana Mihaela Deleanu, Irena Pintea, et al. "Managing Severe Adverse Reactions to Biologicals in Severe Asthma." Biomedicines 11, no. 12 (2023): 3108. http://dx.doi.org/10.3390/biomedicines11123108.

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Background: The use of biological agents in the treatment of various inflammatory and malignancy conditions has expanded rapidly. However, these agents can induce hypersensitivity reactions, posing significant clinical challenges. Methods: We conducted a retrospective study that included nine patients with severe asthma who experienced hypersensitivity reactions to biological agents (omalizumab, benralizumab and dupilumab). Results: Hypersensitivity reactions to biologicals in severe asthma were observed in 9 of 68 patients treated. In five cases, treatment was stopped or changed to another av

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Sergeeva, Galina R., and Alexander V. Emelyanov. "Effectiveness and safety of biological therapy in patients with severe asthma in a real clinical practice." Terapevticheskii arkhiv 96, no. 3 (2024): 240–45. http://dx.doi.org/10.26442/00403660.2024.03.202626.

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Aim. To assess effectiveness and safety of biological therapy in patients with severe asthma during 5 yr follow-up. Materials and methods. We recruited 129 adult outpatients (29% males) aged 18–81 yrs with severe asthma were followed up during 5 yrs and were examined for every 3–6 months. Eighty five patients were treated by conventional therapy (ICS/LABA ± tiotropium, montelukast, OCS) only and 44 pts additionally received biologicals (оmalizumab – 9 pts, мepolizumab – 8 pts, benralizumab – 11 pts, dupilumab – 16 pts). Pulmonary function tests were measured by dry spirometer (2120, Vita

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Gaiderova, L. A., N. A. Alpatova, O. V. Golovinskaya, A. M. Guskov, E. K. Lipatova, and M. N. Lavrova. "Implementation of the 3Rs Concept in Quality Control of Biologicals: Status and Prospects (Review)." Safety and Risk of Pharmacotherapy 13, no. 2 (2025): 229–39. https://doi.org/10.30895/2312-7821-2025-13-2-229-240.

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INTRODUCTION. Many countries are implementing an increasing number of alternatives to animal testing in the research, development, and quality control of medicines under the concept of 3Rs (replacement, reduction, and refinement). However, the implementation of in vitro alternatives to in vivo methods into batch release testing of biologicals, primarily vaccines, is a challenging process. The introduction of the 3Rs principles into regulatory and industry standards requires a comprehensive analysis, including, among other things, a study of specific considerations for national frameworks.AIM.

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Kaper, James B. "Developments in Biological Standardization, Volume 59: Standardization and Control of Biologicals Produced by Recombinant DNA Technology." American Journal of Tropical Medicine and Hygiene 35, no. 4 (1986): 866. http://dx.doi.org/10.4269/ajtmh.1986.35.4.tm0350040866a.

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Malcolm, Sue. "Developments in biological standardization, vol. 59, standardization and control of biologicals produced by recombinant DNA technology." Journal of Immunological Methods 86, no. 2 (1986): 278–79. http://dx.doi.org/10.1016/0022-1759(86)90465-5.

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Vandendorpe, Ann-Sophie, Kurt de Vlam, and Rik Lories. "Evolution of psoriatic arthritis study patient population characteristics in the era of biological treatments." RMD Open 5, no. 1 (2019): e000779. http://dx.doi.org/10.1136/rmdopen-2018-000779.

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ObjectivesPsoriatic arthritis is a chronic inflammatory disease that affects the musculoskeletal system. It can include arthritis, spondylitis, dactylitis and enthesitis, and is strongly associated with the presence of psoriasis. The introduction of biological therapies as a treatment option has brought a significant improvement in disease control for patients with psoriatic arthritis. Here, we aimed to detect emerging differences in demographic and clinical characteristics of the psoriatic arthritis patient study population since the introduction of biologicals. We hypothesised that evolving

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Ashok, kumar P., P. M. Divija, B. R. Reshma, K. R. Bhoomika, and Shree R. Ramya. "Regulatory requirements for approval of biological products as per CDSCO in Indian comparison with South Korea." World Journal of Advanced Research and Reviews 20, no. 1 (2023): 758–67. https://doi.org/10.5281/zenodo.12204079.

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Biologicals are restorative, therapeutic, analytic, preventive, arrangements created or got from living life forms and their turn for human use. Biological products are expected to continue to play a significant role in the future of medicine and health care. They include vaccines, serum, blood and blood products, gene therapy, antibodies, etc. The Indian administrative expert (CDSCO), is the body which is in charge of the advancement and promoting biologics in India. And in South Korea MFDS is responsible for regulations of biologics. <strong>Objective:</strong> Unveiling the differences in r

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Huyen Trang, Canh, Duong Thi Cam Le, Dam Thi Lieu, and Pham Quang Minh. "Determination of total protein content in biologicals using biuret method." JOURNAL OF CONTROL VACCINES AND BIOLOGICALS, no. 1 (December 31, 2021): 118–30. http://dx.doi.org/10.56086/jcvb.vi1.13.

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Biuret is one of the methods of protein quantification with many advantages: fast, simple, accurate, suitable for samples with high protein content and purity. In order to convert the method of determining total protein content in biological products with high protein content from Lowry to Biuret method, from April to December 2018, at the Department of Physical Chemical – National Institute for Control of Vaccine and Biologicals, we have conducted an experimental laboratory research methods to evaluate the suitability of the procedure for determining total protein content by Biuret method on

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Brito, Carlos A. A. de, Claudia D. L. Marques, Rafael F. O. França, et al. "Reduced Duration of Postchikungunya Musculoskeletal Pain in Rheumatological Patients Treated with Biologicals." Journal of Tropical Medicine 2020 (July 10, 2020): 1–6. http://dx.doi.org/10.1155/2020/2071325.

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Chikungunya fever (CHIK) has caused important epidemic outbreaks in the Americas, with musculoskeletal involvement being the main manifestation, causing chronic symptoms in half of the affected patients. This study was performed to evaluate the clinical course of the infection in 168 patients with autoimmune inflammatory disease using biological disease-modifying antirheumatic drugs (bDMARDs), comparing this group with 56 household controls. Anti-CHIKV IgG serology was positive in 42 (25%) of the patients in the bDMARD group and in 15 (27%) of the controls (p=0.79). Of those with positive sero

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Chand, Tara, Manoj Kumar, Brij Bhushan, et al. "Role of the National Control Laboratories in Ensuring the Quality, Safety and Efficacy of Blood Products in India." INTERNATIONAL JOURNAL OF PHARMACEUTICAL QUALITY ASSURANCE 14, no. 04 (2023): 1302–6. http://dx.doi.org/10.25258/ijpqa.14.4.73.

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National control laboratories (NCLs) are responsible for testing of the batches of drugs prior to their release on the market. NCLs play an important role in strengthening a country’s regulatory systems. The National Institute of Biologicals is an NCL in India for the testing and coenzyme A (CoA) release of biologicals such as biotherapeutics, vaccines, and diagnostic medical devices. Every year, the National Institute of Biologicals tests and CoA releases thousands of batches of blood products following compendial specifications and schedule F, part XII-C (G) of Drugs and Cosmetics Rules 1945

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Bernardos, Maria, Natalia Sierra Cornejo, Carmen G. Rodriguez, Jose R.Arevalo, and Raimundo Cabrera. "SCREENING FOR BIOLOGICALS TO CONTROL RUMEX LUNARIA L. IN LANZAROTE ISLAND." Romanian Journal for Plant Protection 14 (2021): 114–26. http://dx.doi.org/10.54574/rjpp.14.15.

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"Rumex lunaria L., a Polygonaceae shrub, has colonized large areas of Lanzarote, Canary Islands, from the 1980s to the present day, revealing an invasive behaviour. Recently, symptoms of disease like leaf spots and lack of turgidity in trunks have been observed. This fact has led to the investigation on fungal communities present in this invasive species in several areas of the National Park and other locations in Lanzarote Island. Our objectives were to detect and select fungal strains with phytopathogenic traits isolated from disease symptomatic plants using different screening techniques. T

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Remington, Kathryn Martin, and Marian McKee. "Evaluation of Disinfection Procedures for Control of Potential Contamination of Biologicals." BioProcessing Journal 14, no. 2 (2015): 14–21. http://dx.doi.org/10.12665/j142.remington.

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Gils, Ann. "Combining Therapeutic Drug Monitoring with Biosimilars, a Strategy to Improve the Efficacy of Biologicals for Treating Inflammatory Bowel Diseases at an Affordable Cost." Digestive Diseases 35, no. 1-2 (2017): 61–68. http://dx.doi.org/10.1159/000449085.

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Background: Biologicals provide a tight disease control but not all patients respond favourably to treatment. Some patients do not respond at all (primary non-responders), while other patients respond initially but show loss of response over time (secondary non-responders). Drug concentrations in the serum of patients can be monitored and correlated with biological, clinical or endoscopic response. Therapeutic thresholds have been defined for infliximab and adalimumab. The European Medicines Agency has approved 3 biosimilars of infliximab and new biosimilars are waiting approval. Key Messages:

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Aledort, Louis M., and James G. Coates. "Hemophilia Treatment - A Model for Appropriate Cost Control." Blood 110, no. 11 (2007): 3942. http://dx.doi.org/10.1182/blood.v110.11.3942.3942.

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Abstract Hemophilia patients consume large quantities of biologicals. Many are on prophylactic regimens which cost substantially more and have better outcomes as compared to on-demand treatment. In either situation, 95% of costs of care are biologics. As costs are high, third-party payers frequently challenge various treatment regimens. Aetna Inc., working with nurses and a hemophilia treater, initiated a systematic evaluation program of 400 members with hemophilia enrolled in HMO plans to investigate whether these costs could be appropriately controlled. Several caveats were agreed to: No the

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Nanau, Radu M., and Manuela G. Neuman. "Safety of Anti-Tumor Necrosis Factor Therapies in Arthritis Patients." Journal of Pharmacy & Pharmaceutical Sciences 17, no. 3 (2014): 324. http://dx.doi.org/10.18433/j3wp4f.

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Purpose. Inflammatory and rheumatic arthritis remain leading causes of disability worldwide. The arthritis therapeutic area commands the largest market for the prescription of biological and non-steroidal anti-inflammatory drugs (NSAID). Yet biotechnology and pharmaceutical companies conducting research and providing therapeutics in this area frequently face challenges in patient safety. The purpose of our study was to assess safety of anti-tumor necrosis factor therapies in arthritis patients. Methods: The present study systematically reviews adverse events of biologicals alone or in the pres

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Abd-Elgawad, Mahfouz M. M. "Optimizing Safe Approaches to Manage Plant-Parasitic Nematodes." Plants 10, no. 9 (2021): 1911. http://dx.doi.org/10.3390/plants10091911.

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Plant-parasitic nematodes (PPNs) infect and cause substantial yield losses of many foods, feed, and fiber crops. Increasing concern over chemical nematicides has increased interest in safe alternative methods to minimize these losses. This review focuses on the use and potential of current methods such as biologicals, botanicals, non-host crops, and related rotations, as well as modern techniques against PPNs in sustainable agroecosystems. To evaluate their potential for control, this review offers overviews of their interactions with other biotic and abiotic factors from the standpoint of PPN

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Hendriksen, Coenraad F. M. "Reduction of Numbers of Animals Used in the Quality Control of Biologicals." Alternatives to Laboratory Animals 32, no. 2_suppl (2004): 53–58. http://dx.doi.org/10.1177/026119290403202s11.

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Allaart, Laurens Jan Houterman, James Lech, Arno Alexander Macken, et al. "Biomodulating healing after arthroscopic rotator cuff repair: the protocol of a randomised proof of concept trial (BIOHACK)." BMJ Open 13, no. 8 (2023): e071078. http://dx.doi.org/10.1136/bmjopen-2022-071078.

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Purpose/introductionOver the last decades, there has been increasing interest in biological stimulation or bioaugmentation after rotator cuff repair. So far, there is no consensus on the appropriate composition of biologicals or which patients would benefit most, and moreover, these biologicals are often expensive. However, there are other, non-pharmacological strategies that are also believed to achieve biological stimulation. This randomised controlled trial evaluates the possible cumulative effect of pragmatic application of cryobiomodulation, photobiomodulation and electrobiomodulation—col

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Feldman, Madelaine, and Michael S. Reilly. "European prescribers’ attitudes and beliefs on biologicals prescribing and automatic substitution." Generics and Biosimilars Initiative Journal 9, no. 3 (2020): 116–24. http://dx.doi.org/10.5639/gabij.2020.0903.020.

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Introduction: The European Union (EU) and the European Medicines Agency (EMA) have led the development of a regulatory framework for biosimilars since 2004. By end of December 2019, 64 biosimilars of 15 originator biological medicines have a marketing authorization in Europe. Now, for the second time, the Alliance for Safe Biologic Medicines (ASBM) asked European prescribers for their views on the prescribing, adverse drug reaction reporting, automatic substitution and switching of biologicals and biosimilars. Methods: In March 2019, the ASBM surveyed 579 prescribers in France, Germany, Italy,

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Hasan, Nasiq, Rohan Chawla, Nawazish Shaikh, Sindhuja Kandasamy, Shorya Vardhan Azad, and M. Dheepak Sundar. "A comprehensive review of intravitreal immunosuppressants and biologicals used in ophthalmology." Therapeutic Advances in Ophthalmology 14 (January 2022): 251584142210974. http://dx.doi.org/10.1177/25158414221097418.

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Systemic immunosuppressants and biologicals have been a valuable tool in the treatment of inflammatory diseases and malignancies. The safety profile of these drugs has been debatable, especially in localized systems, such as the eye. This has led to the search for fairly local approaches, such as intravitreal, subconjunctival, and topical route of administration. Immunosuppressants have been used as a second-line drug in patients intolerable to corticosteroids or those who develop multiple recurrences on weaning corticosteroids. Similarly, biologicals have also been used as the next line of th

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Volkova, R. A., O. V. Fadeikina, O. B. Ustinnikova, et al. "Requirements for the information on reference standards submitted in the dossier for biologicals." Biological Products. Prevention, Diagnosis, Treatment 24, no. 1 (2024): 7–20. http://dx.doi.org/10.30895/2221-996x-2024-24-1-7-20.

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SCIENTIFIC RELEVANCE. The use of appropriately certified reference standards (RSs) is a necessary element of analytical procedure standardisation that ensures comparability of results across different laboratories assessing the quality of medicines, which is important for the quality control of biologicals. Marketing authorisation involves providing information on RSs, but no specific requirements are given for the relevant section of the dossier. Therefore, it is necessary to develop the requirements for the appropriate guidelines.AIM. This study aimed to develop specific requirements for the

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Halder, Marlies, Michael Balls, Coenraad Hendriksen, and Klaus Cussler. "ECVAM's Activities in Promoting the Three Rs in the Quality Control of Biologicals." Alternatives to Laboratory Animals 32, no. 1_suppl (2004): 93–98. http://dx.doi.org/10.1177/026119290403201s14.

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Hendriksen, Coenraad, Klaus Cussler, and Marlies Halder. "ECVAM's Role in the Implementation of the Three Rs Concept in the Field of Biologicals." Alternatives to Laboratory Animals 30, no. 2_suppl (2002): 41–46. http://dx.doi.org/10.1177/026119290203002s06.

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Biologicals can be defined as products that are derived from living organisms or are produced by them. They include vaccines, hormones, monoclonal and polyclonal antibodies, blood products and rDNA products. The production of conventionally produced biologicals requires an extensive batch-related quality control, to ensure that these products are both safe and potent. As several of the control tests rely on animal models, it is inevitable that large numbers of animals are used. Many initiatives have been undertaken in the last few decades to reduce, refine and replace the use of animals in thi

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Mizell, R. F., and D. E. Schiffhauer. "Control of Glyphidocera Juniperella Adamski in Container-Grown Juniper, 1984." Insecticide and Acaricide Tests 11, no. 1 (1986): 411–12. http://dx.doi.org/10.1093/iat/11.1.411a.

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Abstract Liquid insecticides were applied to runoff on 1 Nov 84 to juniper plants in 2-gal pots in a commercial nursery with a Solo hand-pumped compressed-air sprayer at 8.5 kg/cm2 pressure. Granular and bait formulations were applied to pots by hand from premeasured containers. Four replicates/treatment of 5 plants each were arranged in a CRD. Treatments were evaluated at 7, 18, or 25 days posttreatment depending on formulation or mode of action: liquids-7, baits and biologicals-18, and granulars-25 days. Separate controls were evaluated on each day treatments were evaluated.

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Vlasenko*, N. G., V. A. Pavlyushin, O. I. Teplyakova, O. V. Kulagin, and D. O. Morozov. "Protection of spring wheat with biopreparations and fungicides in the forest steppe of Priobye: II. Activity under conditions of moisture deficiency." PLANT PROTECTION NEWS 105, no. 4 (2022): 181–92. http://dx.doi.org/10.31993/2308-6459-2022-105-4-15357.

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The effectiveness of chemical, fungal and bacterial fungicide treatments of spring soft wheat seeds and stands against major diseases was compared on leached chernozem of Novosibirsk region in 2021. Biological preparations including Sternifag, WP (Trichoderma harzianum) showed effect as early as in the tillering phase. The biologicals’ effectiveness in root rot suppression was comparable to Scarlet, ME (imazalil+tebuconazole) and amounted to 62–64 %, while Sternifag, WP halved the disease development. By the end of the growing season, all treatments, including the chemical one, equally suppres

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Novikova, Irina, Vladislav Minin, Julia Titova, et al. "New Polyfunctional Biorationals Use to Achieve Competitive Yield of Organic Potatoes in the North-West Russian Ecosystem." Plants 11, no. 7 (2022): 962. http://dx.doi.org/10.3390/plants11070962.

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To increase the organic potato yield, it is necessary to provide the crop with sufficient nutrients and effective means of biocontrol the diseases. The research goal was to characterize the biorationals’ efficacy to achieve competitive organic potatoes’ yield under various weather conditions. A 4-year trial was carried out in the Leningrad region using Udacha variety potatoes. The tests used liquid forms of new polyfunctional biologicals Kartofin based on highly active Bacillus subtilis I-5-12/23 and organic fertilizer BIAGUM obtained from poultry manure by aerobic fermentation in a closed bio

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Mitkova, Zornitsa, Ivan Manev, Konstantin Tachkov, et al. "How Managed Entry Agreements Influence the Patients’ Affordability to Biological Medicines—Bulgarian Example." Healthcare 11, no. 17 (2023): 2427. http://dx.doi.org/10.3390/healthcare11172427.

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Managed entry agreements are applied in almost all European countries in order to improve patients’ access to therapy. The current study aims to evaluate the changes in the affordability of biological medicines for patients in Bulgaria during 2019–2022. The study is a top-down macroeconomic analysis of the key economic indicators and reimbursed costs of biologic therapies. Affordability was determined as the number of working hours needed to pay for monthly therapy. The average NHIF budget for pharmaceuticals increased significantly along with inflation in the healthcare sector. Bulgarian pati

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Husband, Alan J. "Section Review: Biologicals and Immunologicals: Novel developmental vaccines for the control of mucosal infection." Expert Opinion on Investigational Drugs 3, no. 9 (1994): 895–906. http://dx.doi.org/10.1517/13543784.3.9.895.

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Aliu, Arta, Zlatan Mujagic, Mariëlle Romberg-Camps, Steven F. Jeuring, Adriaan A. Van Bodegraven, and Marie J. Pierik. "Mo1253: EFFECT OF NOVEL BIOLOGICALS AND SMALL MOLECULES ON SUBJECTIVE DISEASE CONTROL IN IBD." Gastroenterology 169, no. 1 (2025): S—1070. https://doi.org/10.1016/s0016-5085(25)03366-9.

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Nanau, Radu M., Lawrence E. Cohen, and Manuela G. Neuman. "Risk of Infections of Biological Therapies with Accent on Inflammatory Bowel Disease." Journal of Pharmacy & Pharmaceutical Sciences 17, no. 4 (2014): 485. http://dx.doi.org/10.18433/j3gg6d.

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Background: Biological therapies using anti-tumor necrosis factor (TNF)-α agents have an important impact in the treatment of inflammatory bowel disease, rheumatoid arthritis, psoriasis, and other inflammatory conditions. However, a significant number of patients lose their response to these medications over time. Clinical trials have demonstrated that antibodies against anti-TNF agents may impact treatment response and increase the risk of infusion reactions. Of concern is also the possibility of developing adverse events induced by anti-TNF agents. The purpose of the present systematic revie

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Xavier, Katia V., and Gary E. Vallad. "Efficacy of Biological and Conventional Fungicide Programs for Foliar Disease Management on Pomegranate (Punica granatum) in Florida." Plant Health Progress 21, no. 3 (2020): 199–204. http://dx.doi.org/10.1094/php-02-20-0012-rs.

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Pomegranate (Punica granatum L.) is an emerging alternative perennial crop in the southeastern United States. However, foliar diseases are present across this production area, causing almost 100% premature defoliation. A series of fungicide efficacy trials were conducted to evaluate biological, systemic, and contact fungicides at two locations in Florida, Plant City (cv. Angel Red) and Parrish (cvs. Christina, Azadi, Vikusnyi, Alsirinnar, Sakerdze, and Wonderful), for foliar disease management. Based on AUDPC, the fungicides Captan 80 WDG (captan, 78.2%), Penncozeb 75DF (mancozeb, 75%), Merivo

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Tosca, Maria Angela, Donata Girosi, Oliviero Sacco, Roberto Bernardini, and Giorgio Ciprandi. "Steroid-sparing effect of mepolizumab in children with severe eosinophilic nonallergic asthma." Allergologia et Immunopathologia 49, no. 5 (2021): 113–16. http://dx.doi.org/10.15586/aei.v49i5.466.

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Background: Asthma is characterized by a chronic airway inflammation, usually sustained by type 2 immunity. Bronchial and peripheral eosinophilia are biomarkers for type 2 asthma. Biologicals are the most effective treatment for severe asthma at present. Mepolizumab is an antagonist of interleukin-5 (IL-5), the most relevant cytokine involved in eosinophilia.Objective: This case report evaluated the effectiveness of mepolizumab in two girls with severe eosinophilic non-allergic asthma.Materials and methods: Two female children with severe eosinophilic nonallergic asthma were treated with mepol

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Thi Van Quynh, Nguyen, Nguyen Thi Mai Huong, Nguyen Thu Quynh, Nguyen Thi Thu Thuy, and Nguyen Khanh Ly. "Apply Mycoflour kit for detection of Mycoplasma in cell lines at National Institute for Control of Vaccines and Biologicals." JOURNAL OF CONTROL VACCINES AND BIOLOGICALS, no. 1 (December 31, 2021): 43–55. http://dx.doi.org/10.56086/jcvb.vi1.4.

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Control of Mycoplasma in cell culture used in testing is necessary to ensure the accuracy of quality control and vaccine release. Research on fluorescent dyeing process using Mycoplasma detection cell indicators to develop standard operating procedures before routinely used at National Institute for Control of Vaccines and Biologicals (NICVB). Outcome showed that the parameters of the Mycoplasma detection procedure by the Vero cell indicator method using the MycoFlourTM kit at NICVB were optimized for the concentration of Vero cells inoculated into coverslip 10 x104 TB/ml; Wash cells twice wit

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Khanh Linh, Do, Bui Thi Kim Xuyen, Le Thi Hoang Yen, Nguyen Phuong Lien, Nguyen Thi Kim Ngan, and Ngo Thi Hoa. "Evaluation of the potency of Tetanus national reference standard vaccine RT4-01 for quality control of Tetanus vaccine." JOURNAL OF CONTROL VACCINES AND BIOLOGICALS, no. 1 (December 31, 2021): 112–17. http://dx.doi.org/10.56086/jcvb.vi1.12.

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The study determined the average number of potency units in a Tetanus national reference standard lot RT4-01 at the time of the study (2016-2017) by five independent experiments. The results determine that the potency of the standard sample RT4-01 was 545 IU/tube, which meets the standards of the World Health Organization for use in the tetanus efficacy test at the National Institute for Control of Vaccines and Biologicals (NICVB).

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Belyaev, Vladimir I., Roman E. Prokopchuk, Olga V. Cherepanova, and Liudmila V. Sokolova. "Grain quality and spring soft wheat yield when grown using biologicals "Azofit N" and "Azofit P"." Far Eastern Agrarian Herald 17, no. 4 (2023): 7–13. https://doi.org/10.22450/1999-6837-2023-17-4-7-13.

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The purpose of this work is to analyze the spring wheat yield and grain quality when grown using agricultural biologicals "Azofit N" and "Azofit P" against the background of reducing doses of mineral fertilizers in various soil fertility zones of fields compared to the basic option of their use. "Azofit" is a microbiological fertilizer with fungicidal and stimulating properties. The place where the experiments were carried out was APC "Kolos", located in East Kulunda arid steppe zone. This zone is characterized by insufficient moisture during the growing season with a large amount of heat and

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Oh, Hokyung, Jinho Shin, Chung Keel Lee, et al. "The 2nd Meeting of National Control Laboratories for Vaccines and Biologicals in the Western Pacific." Osong Public Health and Research Perspectives 9, no. 3 (2018): 133–39. http://dx.doi.org/10.24171/j.phrp.2018.9.3.10.

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Nguyen Thi Van Quynh, Pham Van Hung, Doan Huu Thien, et al. "EVALUATING THE QUALITY OF VERO 76 CELL BANK NATIONAL REFERENCE STANDARD USED FOR QUALITY CONTROL OF VACCINES AND BIOLOGICALS PRODUCTS USED IN TESTING VACCINES AND BIOLOGICALS PRODUCTS." JOURNAL OF CONTROL VACCINES AND BIOLOGICALS 3, no. 3 (2023): 4–17. http://dx.doi.org/10.56086/jcvb.v3i3.101.

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The Master cell bank (Vero 76 NICVB/MCB01-18) and Working cell bank (Vero 76 NICVB/WCB01-19) are produced from international standard Vero cells ATCC 76 (ATCC CRLM- 1587TM) was studied and evaluated for quality according to the standards of the World Health Organization (WHO) including criteria such as (identification; sterility; homogeneity; viability; Mycoplasma; Retrovirus; tuberculosis bacteria; extraneous agents in vitro and in vivo). The research results show that the cell banks Vero 76 NICVB/MCB01-18 and Vero 76 NICVB/WCB01-19 meet the quality requirements according to WHO TRS 978, part

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Figueiredo-Braga, Margarida, Caleb Cornaby, Alice Cortez, et al. "Influence of Biological Therapeutics, Cytokines, and Disease Activity on Depression in Rheumatoid Arthritis." Journal of Immunology Research 2018 (July 17, 2018): 1–9. http://dx.doi.org/10.1155/2018/5954897.

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Purpose. Rheumatoid arthritis (RA) is an often debilitating autoinflammatory disease. Patients with rheumatoid arthritis are often troubled by co-occurring depression or other psychological manifestations. RA patients have a variety of treatment options available, including biologicals that inhibit cytokines or immune cells. If these cytokines influence the psychological symptoms, then the use of cytokine inhibitors should modulate these symptoms. Methods. A cohort of 209 individuals was recruited. This group included 82 RA patients, 22 healthy subjects, 32 depressed control subjects, and 73 s

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Noetzel, David, and Cliff Watrin. "Biological and Synthetic Insecticide Combinations for Control of Resistant Colorado Potato Beetle, Big Lake, MN, 1992." Insecticide and Acaricide Tests 18, no. 1 (1993): 149–50. http://dx.doi.org/10.1093/iat/18.1.149.

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Abstract This trial was established to compare several combinations of biologicals and synthetic materials for control of resistant CBP. Plots were established in a commercial potato field and consisted of 4 rows, 0.91 m wide and 9.1 m long. Treatments were arranged in a randomized complete block, replicated 3 times. The entire plot area was treated for adult control on 18 May and 24 Jun. The foliars were applied on 2, 12, 18, and 27 Jun, and then sprayed off with Karate 1 E 0.028 kg Al/ha on 7 Jul. Defoliation readings and larval ratings were taken 12, 18, 27 Jun, and 7 Jul.

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Zamora-Avilés, Norma, Alonso A. Orozco-Flores, Teodora Cavazos-Vallejo, et al. "Intra-Phenotypic and -Genotypic Variations of Beauveria bassiana (Bals.) Vuill. Strains Infecting Aedes aegypti L. Adults." International Journal of Molecular Sciences 25, no. 16 (2024): 8807. http://dx.doi.org/10.3390/ijms25168807.

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Beauveria bassiana has potential for Aedes aegypti biological control. However, its efficacy depends on the strain’s geographic location, host susceptibility, and virulence. The present study aimed to evaluate the effectiveness of B. bassiana strain BBPTG4 conidia in controlling Ae. aegypti adults and its detection via introns profile on exposed mosquito corpses. Morphologic characteristics among strains were highly similar. Comprehensive testing of these strains demonstrated that BBPT4 exhibited the ideal biological activity for Ae. aegypti control, with a median lethal time (TL50) of 7.5 d c

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Rivarez, Mark Paul Selda, Elizabeth P. Parac, Niño R. Laurel, Benjamin V. Cunanan, Angelie B. Magarro, and Shajara Fatima M. Dimasingkil. "Antagonistic activity of bacteria from wild honey against Colletotrichum musae, and testing of wild honey as biopesticide spray to control banana anthracnose." Bioscience Journal 37 (December 29, 2021): e37089. http://dx.doi.org/10.14393/bj-v37n0a2021-49921.

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Anthracnose is a foliar and fruit disease caused by Colletotrichum spp. affecting a wide range of crops. Infection occurs early followed by quiescence in fruits, such as in banana, where chemical-based pesticides are used as a dependable fungal control for many years. There is an increasing need for a safe control and as implicated in the Organic Agriculture Act of 2010 (RA 10068) in the Philippines. This scenario drove the use of alternative pest control such as the use of biologicals and natural products. In this study, seven bacteria were isolated from wild honey, produced by Apis mellifera

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Silchenko, Katerina, and Taisiya Ryzhkova. "Influence of vegetable biostimulators on physical and chemical parameters of cows’ milk." Roczniki Naukowe Polskiego Towarzystwa Zootechnicznego 17, no. 2 (2021): 1–10. http://dx.doi.org/10.5604/01.3001.0015.3058.

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<b>The results of a comparative study of the effectiveness of plant biostimulators “Biosvit” and “Megasvit” on changes in the physicochemical composition of milk, which was obtained from dairy cows of the Ukrainian black-and-white dairy breed, kept in Ltd “Renaissance +1881” Zolochivskyi district of Kharkiv region are reflected in the article. There were used 2 biological batches in our studies. One batch of the biological product was made on the basis of a dry mixture, which is called ‘11-Tigers by “Eleven Tigers Herbal Bar Energizer” and consists of seven species of plants of foreign o

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