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Rozprawy doktorskie na temat „Controlled and sustained release”

Autor: Grafiati

Data publikacji: 7 czerwca 2025

Data aktualizacji: 2 sierpnia 2025

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1

Rodriguez, Lidia Betsabe. "Controlled Release System for Localized and Sustained Drug Delivery Applications." University of Toledo / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1365107103.

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Khamanga, Sandile Maswazi Malungelo. "Formulation and assessment of verapamil sustained release tablets." Thesis, Rhodes University, 2005. http://hdl.handle.net/10962/d1018236.

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The oral route of drug administration is most extensively used due to the obvious ease of administration. Verapamil hydrochloride is a WHO listed phenylalkylarnine, L-type calcium channel antagonist that is mainly indicated for cardiovascular disorders such as angina pectoris, supraventricular tachycardia and hypertension. Due to its relatively short half-life of approximately 4.0 hours, the formulation of a sustained-release dosage form is useful to improve patient compliance and to achieve predictable and optimized therapeutic plasma concentrations. Direct compression and wet granulation wer

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3

Li, Anqi. "Injectable hydrogels for controlled and sustained local drug delivery." Electronic Thesis or Diss., université Paris-Saclay, 2025. http://www.theses.fr/2025UPASQ014.

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Les hydrogels injectables sont largement explorés en tant que réservoirs pour une administration locale de substances actives (SA) afin d'en augmenter la biodisponibilité et réduire la toxicité systémique. En oncologie, une telle approche peut être particulièrement pertinent par exemple dans le traitement de la carcinose péritonéale pour laquelle le protocole thérapeutique standard repose sur une chirurgie cytoréductive suivie de l'administration intrapéritonéale (IP) d'une thermo-chimiothérapie (HIPEC). Cependant, les SA administrés par voie intrapéritonéale ont un temps de résidence court en

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4

McLellan, Bradley John. "Development of an Intraruminal Controlled-Release Device." The University of Waikato, 2007. http://hdl.handle.net/10289/2527.

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Slow-release devices retained in the rumen, are a simple method for continuous administration of bioactives to ruminant animals. To satisfy regulatory requirements and avoid waste of bioactive due to under- or over-dosing, it is advantageous to have a constant and predictable release rate. Existing intraruminal controlled-release technologies cannot easily be adapted for different bioactives or rates of release and can be influenced by the variable physiological environment in the rumen. Some existing commercial products use the pressure generated by a hydrogen gas-producing cell to extrude

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5

Sachikonye, Tinotenda Chipo Victoria. "Development and assessment of minocycline sustained release capsule formulations." Thesis, Rhodes University, 2010. http://hdl.handle.net/10962/d1013127.

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The use of minocycline for the treatment of a broad range of systemic infections and for severe acne has been associated with vestibular side effects. The severity of side effects may lead to poor adherence to therapy by patients. The use of sustained release formulations of minocycline that display slow dissolution of minocycline following administration may be beneficial in reducing the incidence and severity of side effects. Therefore, sustained release capsule dosage forms containing 100 mg minocycline (base) were manufactured and assessed for use as sustained release oral dosage forms of

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6

Kao, Chen-Yu. "Developing a Minimally Invasive Sustained Release System for Glioma Therapy." Thesis, Georgia Institute of Technology, 2007. http://hdl.handle.net/1853/19757.

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Malignant brain tumor is one of the most lethal forms of cancers. In the United States alone, approximately 20,500 new cases of primary malignant brain and central nervous system tumors are expected to be diagnosed in 2007 with 12,740 deaths estimated. Treatment of malignant brain tumor remains a major challenge despite recent advance in surgery and other adjuvant therapies, such as chemotherapy. The failure of potential effective chemotherapeutics for brain tumor treatment is usually not due to the lack of potency of the drug, but rather can be attributed to lack of therapeutic strategies ca

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7

Yeh, Hsi-wei. "Investigation of Polymeric Composites for Controlled Drug Release." VCU Scholars Compass, 2017. http://scholarscompass.vcu.edu/etd/4971.

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The Electrospray (ES) technique is a promising particle generation method for drug delivery due to its capabilities of producing monodisperse PLGA composite particles with unique configurations and high drug encapsulation efficiency. In the dissertation work, the coaxial dual capillary ES was used to generate drug-loaded core-shell PLGA particles to study the effects of particle filling materials, drug loading locations and particle shell thicknesses on the resultant in vitro release behaviors of the hydrophilic and/ or hydrophobic model drugs. Through release profile characterization of drug-

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8

Mohl, Silke. "The Development of a Sustained and Controlled Release Device for Pharmaceutical Proteins based on Lipid Implants." Diss., lmu, 2004. http://nbn-resolving.de/urn:nbn:de:bvb:19-30092.

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9

Patel, Fathima. "The development and assessment of a generic carbamazepine sustained release dosage form." Thesis, Rhodes University, 2006. http://eprints.ru.ac.za/1339/.

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10

Wang, Qing. "STRATEGIES FOR SUSTAINED RELEASE OF SMALL HYDROPHILIC DRUGS FROM HYDROGEL BASED MATRICES." University of Akron / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=akron1515164088562922.

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11

Marquette, Sarah. "Stabilization and development of sustained-release formulations of protein/antibody for subcutaneous delivery." Doctoral thesis, Universite Libre de Bruxelles, 2014. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/209251.

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ABSTRACT<p><p>This project aimed at developing a drug delivery system (DDS) able to enhance the stability and<p>residence time in vivo of antibodies (Abs). The system will deliver drug by the subcutaneous<p>route (SC), while ensuring accurate control of the drug release and the resulting plasmatic level. This technology platform will allow to reduce frequency of injection, potentially decrease side effects and maintain high concentration of Abs which will improve life of patient having chronic disease such as autoimmune and inflammatory disease. Biodegradable synthetic polymer-based formulatio

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12

Ito, Ran. "Adipogenesis using human adipose tissue-derived stem cells sustaining release of basic fibroblast growth factor." Kyoto University, 2014. http://hdl.handle.net/2433/188645.

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13

Ogino, Shuichi. "Efficacy of the dual controlled release of HGF and bFGF impregnated with a collagen/gelatin scaffold." Kyoto University, 2018. http://hdl.handle.net/2433/231010.

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14

Jasti, Bhaskara Rao. "Characterization of polymorphic forms and in vitro release of etoposide from poly-DL-lactic and poly-DL-lactic-co-glycolic acid micromatrices." Scholarly Commons, 1995. https://scholarlycommons.pacific.edu/uop_etds/2654.

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Etoposide has been shown to be effective in the treatment of testicular and small-cell lung cancers, lymphoma, leukemia and Kaposi's sarcoma. Several clinical investigations have suggested that the prolonged maintenance of greater than 1 $\mu$g/ml concentration in plasma would provide better therapeutic response in patients. Thus use of a sustained/controlled release formulation of etoposide was indicated. This investigation focused on the potential for the development of a sustained/controlled release dosage form of etoposide for a 7-15 day delivery using selected polylactic and polylactic-co

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15

Cantin, Oriane. "PEO hot melt extrudates for controlled drug delivery." Thesis, Lille 2, 2016. http://www.theses.fr/2016LIL2S035/document.

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Parmi les procédés de fabrication continue, l’extrusion par fusion à chaud est une technique dont l’intérêt dans le domaine pharmaceutique est grandissant. Ce procédé permet la formation des dispersions solides des substances actives au sein des matrices polymériques ou lipidiques. En fonction de l’excipient et de la substance active, cela peut être largement utilisé pour la conception des systèmes: (i) pour une libération immédiate, (ii) pour une libération modifiée et (iii) pour le masquage de goût. Les systèmes à libération modifiée sont des dispositifs intéressants qui permettent d’amélior

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16

Chaibva, Faith Anesu. "The use of response surface methodology and artificial neural networks for the establishment of a design space for a sustained release salbutamol sulphate formulation." Thesis, Rhodes University, 2010. http://hdl.handle.net/10962/d1010432.

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Quality by Design (QbD) is a systematic approach that has been recommended as suitable for the development of quality pharmaceutical products. The QbD approach commences with the definition of a quality target drug profile and predetermined objectives that are then used to direct the formulation development process with an emphasis on understanding the pharmaceutical science and manufacturing principles that apply to a product. The design space is directly linked to the use of QbD for formulation development and is a multidimensional combination and interaction of input variables and process p

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17

Deguettes, Quentin. "Conception, caractérisation et évaluation de formes galéniques à libération prolongée pour l’administration parentérale d’une protéine naturelle destinée à stimuler l’ovulation chez la vache Controlled delivery of follicle-stimulating hormone in cattle." Thesis, université Paris-Saclay, 2020. http://www.theses.fr/2020UPASQ016.

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La stimulation de l’ovulation chez la vache (superovulation) est nécessaire dans les élevages de bovins pour optimiser la balance coût/production. Pour cela, des traitements nécessitant un nombre important d’injections sur plusieurs jours d’une protéine naturelle existent depuis de nombreuses années. La mise au point d’un système simple à manipuler, garantissant la stabilité de la protéine et permettant de prolonger sa libération apporterait un réel bénéfice pour l’utilisateur (éleveur et/ou vétérinaire) et l’animal. Dans ce travail, nous avons, premièrement, mis en place des méthodes de carac

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18

Awosika, Ajoritsedere. "Biopharmacy of sustained-release theophylline." Thesis, University of Bradford, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.257819.

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19

Cook, Robert Owen. "Sustained release microparticles for pulmonary administration." Thesis, University College London (University of London), 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.408442.

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20

Purkiss, Ronald. "Bioequivalence of sustained release theophylline formulations." Thesis, Aston University, 1986. http://publications.aston.ac.uk/12472/.

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The bioequivalence of sustained release theophylline formulations, marketed in the United Kingdom, has been investigated in relation to the co-administration of food in both single dose and steady state volunteer studies. The effect of food on pharmacokinetic parameters and their clinical relevance was researched. Experimentation using drug induced modification of gastric motility to ascertain the component influences of the rate of gastric emptying on the absorption of theophylline from sustained release formulations was conducted. Prolongation of time to maximum plasma theophylline concentra

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21

Pakalapati, Lalita Varma V. (Lalita Varma Venkata) 1976. "Controlled release microchip." Thesis, Massachusetts Institute of Technology, 2003. http://hdl.handle.net/1721.1/7976.

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Thesis (M. Eng.)--Massachusetts Institute of Technology, Dept. of Materials Science and Engineering, 2003.<br>Includes bibliographical references (leaf 34).<br>Microchips for constant release are not a new concept, but a controlled release chip, which does pulsatile release at variable time intervals, is clearly more efficient and useful. The process was completely understood about the theory of operation, the manufacturing procedure and the robustness of the controlled release microchip. The complete application analysis has been done along with the intellectual property study. The study invo

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22

Mantzavinou, Aikaterini. "Sustained-release implants for intraperitoneal cisplatin delivery." Thesis, Massachusetts Institute of Technology, 2018. http://hdl.handle.net/1721.1/120884.

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Thesis: Ph. D. in Medical Engineering, Harvard-MIT Program in Health Sciences and Technology, 2018.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references (pages 217-226).<br>The objective of this work was to develop materials for continuous low-dose delivery of cisplatin directly into the abdomen, also known as intraperitoneal (IP) chemotherapy. IP chemotherapy can help treat peritoneal metastasis in many advanced gynecologic and gastrointestinal cancers and has shown particular promise in treating advanced ovarian cancer. It is however tremendously underutilized beca

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23

McMillan, Hannah Louise. "Sustained release biodegradable ocular drug delivery systems." Thesis, Queen's University Belfast, 2015. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.678216.

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Delivery of drugs to the posterior segment of the eye is notoriously difficult and unfortunately many chronic conditions of the posterior segment often lead to sight-loss if not treated effectively. Current methods of delivery such as topical drops result in poor bioavailability at the back of the eye, while the blood brain retina imposes restrictions on the entry on drugs into the eye delivered by the systemic system. The gold-standard method for delivery of therapeutic concentrations of drugs is intravitreal delivery, which involves an injection into the vitreous cavity. Although this provid

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24

Pirone, Domenico. "Smart Controlled Release Membranes." Doctoral thesis, Universitat Rovira i Virgili, 2020. http://hdl.handle.net/10803/671550.

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L’objectiu d’aquest projecte de doctorat és millorar el rendiment dels dispositius Air Care que desenvolupen una membrana que pot alliberar les matèries primeres de perfum carregades a l’interior de l’embassament sense ser extremadament afectades per les fluctuacions de temperatura del medi extern, sent així menys significatives. sensible a la temperatura que la membrana actual usada en els productes actuals. Per fer-ho, la membrana principal es recobrirà amb un polímer modificat amb nous fragments d’azobenzen. Aquest sistema es pot desencadenar per la llum perquè actuï com una porta intel·lig

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25

Stockwell, A. F. "Oral controlled release formulations." Thesis, University of Nottingham, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.355630.

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26

Santini, John Thomas 1972. "A controlled release microchip." Thesis, Massachusetts Institute of Technology, 1999. http://hdl.handle.net/1721.1/8742.

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Thesis (Ph.D.)--Massachusetts Institute of Technology, Dept. of Chemical Engineering, 1999.<br>"September 1999."<br>Includes bibliographical references.<br>It is well known that the method by which a drug is delivered can have a significant effect on the drug's therapeutic efficacy. There exist numerous cases where constant release is not the optimal method of drug delivery; instead, delivery of pulses of drug at variable time intervals is the preferred method. This method is commonly referred to as pulsatile delivery, and it is preferred in some cases because it closely mimics the way in whic

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27

Learoyd, Tristan P. "Controlled release in inhalation." Thesis, Aston University, 2007. http://publications.aston.ac.uk/11061/.

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Inhalation has become an increasingly viable alternate route to oral dosing, with the advantage of treating local disease with minimal systemic side effects (Hickey, 1992). However, increasingly complicated medication regimens associated with the necessity of the repeated dosing of multiple agents used in treating pulmonary disease has been shown to compromise both disease management and patient convenience. In this study the viability of spray drying to introduce controlled release vectors into dry powders for inhalation was investigated. The first experimental section highlights the use of l

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28

Coleman, M. D. "Studies on the release of pyrimethamine from conventional and sustained release preparations." Thesis, University of Liverpool, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.356260.

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29

Lowry, Deborah. "Sustained release strategies for HIV microbicides and vaccines." Thesis, Queen's University Belfast, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.486247.

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Human immunodeficiency virus (HIV) lolls more people worldwide than' any other infectious disease. The main mode of transmission of HN is unprotected heterose~al intercourse with an infected partner. There is a need for the development of female controlfed preventative strategies. the most promising approach currently being pursued is the development of vaginally administeled HN. microbicides. The release profiles from silicone intravaginal rings (lVRs) of (i) potential HN fusion inhibitors. dextran sulfate (OS) and ceJJuJose sulfate (CS). (ii) organic acid species, and .(iii) bovine serum alb

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30

Fetherston, S. M. "Novel Sustained Release Divices for Vaginal Drug Administration." Thesis, Queen's University Belfast, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.527695.

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31

Dennis, Andrew Barriball. "Sustained drug release from semi-solid capsule formations." Thesis, Cardiff University, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.328069.

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32

Lee, Jobina J. N. "Investigations into sustained-release hydrophobic matrix pellet formulations." Thesis, University of Strathclyde, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.275167.

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33

Mhaka, Farai Arthur. "Development and manufacture of sustained release captopril beads." Thesis, Rhodes University, 2015. http://hdl.handle.net/10962/54712.

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Hypertension has a high mortality rate in developing countries such as South Africa. Although the prevention and control of hypertension is a health priority, efforts to decrease the global burden of hypertension and improve control over the condition are inadequate. The use of angiotensin converting enzyme (ACE) inhibitors such as captopril (CPT) have been effective for the management of hypertension when used as first line therapy alone or in combination. Commercially available immediate release dosage forms containing 12.5, 25 and 50 mg of CPT are administered two or three times a day to tr

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34

Hussey, Jeremy Steven. "Wood in controlled release technology." Thesis, Bangor University, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.263193.

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35

Feely, L. C. "Controlled release hydroxypropylmethylcellulose mini-matrices." Thesis, University of Nottingham, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.373348.

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36

Holland, Simon J. "Novel polymeric controlled release systems." Thesis, Aston University, 1986. http://publications.aston.ac.uk/14511/.

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37

Fahier, Julie. "Polymeric controlled release film coatings." Thesis, Lille 2, 2016. http://www.theses.fr/2016LIL2S025/document.

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Les mini-granules enrobées offrent un grand potentiel pour la libération contrôlée de médicament par voie orale. Cependant, les mécanismes de libération impliqués ne sont pas toujours élucidés et compris. Ainsi, l’impact de certains paramètres de formulation peut être surprenant. Par exemple, il a été démontré dans ce travail :- La libération du propranolol HCl à partir de mini-granules enrobées avec du Kollicoat SR est plus lente si les mini-granules sont composées de noyaux de sucre comparé à des noyaux de cellulose microcristalline (CMC).Généralement, la tendance inverse est observée, car l

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38

Wagner, Daniel. "Sustained release formulations for compounds underlying intestinal drug efflux." [S.l.] : [s.n.], 2003. http://deposit.ddb.de/cgi-bin/dokserv?idn=96927890X.

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Wilding, Ian Robert. "Some studies of oral sustained release of pellet systems." Thesis, University of Nottingham, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.319343.

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Mwila, Chiluba. "The development and assessment of sustained release nevirapine tablets." Thesis, Rhodes University, 2013. http://hdl.handle.net/10962/54667.

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The use of antiretroviral (ARV) agents in the management of HIV/AIDS has significantly improved the lifestyle and wellbeing of patients. Despite the success that has been achieved with the use of ARV therapy, the occurrence of adverse effects and unpredictable bioavailability associated with most of these drugs remains a major concern. Nevirapine (NVP) is a non-nucleoside reverse transcriptase inhibitor (NNRTI) that is used in combination with other ARV compounds for the treatment of HIV-1 infections. It is also used for the prevention of mother to child transmission of the HIV-1 virus. NVP is

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Zindove, Chiedza Cathrine. "Development and assessment of sustained release stavudine loaded microparticles." Thesis, Rhodes University, 2014. http://hdl.handle.net/10962/54722.

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Stavudine (D4T) has been used as first line treatment for HIV/AIDS and is part of highly active anti retroviral treatment (HAART). It is an affordable medicine and its use is beneficial in resource limited settings. However D4T exhibits dose dependent side effects that may lead to non-adherence in patients. This study was undertaken to formulate, develop and manufacture a dosage form that could reduce dose dependent side effects by decreasing the dose of D4T but still exhibit antiretroviral (ARV) activity. The use of sustained release (SR) formulations of D4T that ensure constant levels of the

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42

Pygall, Samuel R. "Critical processes in drug release from HPMC controlled release matrices." Thesis, University of Nottingham, 2009. http://eprints.nottingham.ac.uk/14128/.

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This study has investigated the drug release mechanisms from hydroxypropyl methylcellulose (HPMC) hydrophilic matrices. A hypothesis was developed from interpretation of a previous study that drug surface activity has an influence on drug liberation. The validity of the hypothesis was tested by studying the interactions between HPMC and the two non-steroidal anti-inflammatory drugs diclofenac Na and meclofenamate Na, using tensiometry, rheology, NMR, neutron scattering and turbimetry. Meclofenamate Na was found to interact with HPMC, resulting in detectable changes in drug diffusion coefficien

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Chan, Cheuk-ming. "Controlled protein release from collagen matrix." Click to view the E-thesis via HKUTO, 2007. http://sunzi.lib.hku.hk/HKUTO/record/B3955868X.

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Chan, Cheuk-ming, and 陳卓銘. "Controlled protein release from collagen matrix." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2007. http://hub.hku.hk/bib/B3955868X.

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45

Gilligan, Claire A. "Controlled release polymeric films and pellets." Thesis, Queen's University Belfast, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.336028.

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Wong, Lai Pun. "Controlled-release matrices for oral administration." Thesis, Queen's University Belfast, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.336033.

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47

Sheldon, Jonathon. "Light Controlled Drug Activation and Release." VCU Scholars Compass, 2015. http://scholarscompass.vcu.edu/etd/4055.

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Cancer constitutes a terrible burden on modern society. In the United States there are an estimated 1,658,370 new cancer diagnoses resulting in 589,430 deaths in 2015 alone.[1] An estimated 41,170 of these cases will be diagnosed right here in Virginia. With new cancer patients comes the expanding demand for new treatments. As we all know, many modern chemotherapeutics cause adverse reactions to patients. This is because the toxic nature of these therapies often affects normal tissue alongside the tumors that are infesting the body. Therefore, researching novel ways to make chemotherapeutics s

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48

Makan, Anjana. "Development and assessment of gastric-retentive sustained release metronidazole microcapsules." Thesis, Rhodes University, 2017. http://hdl.handle.net/10962/59240.

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Oridota, Omoyosola Omolola. "Development and assessment of gastroretentive sustained release captopril micro-balloons." Thesis, Rhodes University, 2018. http://hdl.handle.net/10962/63491.

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Lewis, Karen Jane. "Biodegradable polymers for the sustained release of antisense nucleic acids." Thesis, Aston University, 1996. http://publications.aston.ac.uk/11054/.

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Antisense oligodeoxynucleotides can selectively inhibit individual gene expression provided they remain stable at the target site for a sufficient period of time. Thus, the efficacy of antisense oligodeoxynucleotides may be improved by employing a sustained release delivery system which would protect from degradation by nucleases whilst delivering the nucleic acid in a controlled manner to the site of action. Biodegradable polymer films and micro spheres were evaluated as delivery devices for the oligodeoxynucleotides and ribozymes. Polymers such as polylactide, polyglycolide, polyhydroxybutyr

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