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Rozprawy doktorskie na temat „Corneal epithelial cells”

Autor: Grafiati
Data publikacji: 4 czerwca 2021
Data aktualizacji: 21 lutego 2023

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1

Liu, Ke. "Role of second messengers in controlling growth patterns of corneal epithelial cells /." View thesis, 2002. http://library.uws.edu.au/adt-NUWS/public/adt-NUWS20030718.102224/index.html.

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Thesis (Ph. D.)--University of Western Sydney, 2002.<br>"This thesis is submitted in fulfilment of the requirements of the degree of Doctor of Philosophy to the University of Western Sydney School of Biological Sciences."t.p. Includes bibliographical references (leaves 138-150).
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Binti, Kamarudin Taty Anna. "Differentiation of human pluripotent stem cells into corneal epithelial like cells." Thesis, University of Newcastle upon Tyne, 2018. http://hdl.handle.net/10443/4182.

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Cornea is the clear outermost protective layer of the eye which enables transmission of light onto the retina. The corneal epithelium is regenerated by limbal stem cells (LSCs), whose loss/dysfunction results in limbal stem cell deficiency (LSCD). Transplantations of ex vivo expanded autologous LSCs from patient's healthy eye onto the affected eye have provided a successful treatment for unilateral LSCD. This however is not applicable to patient with total bilateral LSCD, whose both eyes are affected. This thesis investigated the potential of human induced-pluripotent stem cell (hiPSCs) to dif
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Liu, Ke. "Role of second messengers in controlling growth patterns of corneal epithelial cells." Thesis, View thesis, 2002. http://handle.uws.edu.au:8081/1959.7/387.

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The purpose of this thesis was to investigate mechanisms contolling the growth of corneal epithelial cells, particularly the intracellular signals involved with stratification compared with cellular migration and maturation. Buttons of epithelium were cultured in different culture media. The explants were monitored microscopically for their growth patterns and finally fixed and examined for cytokeratin, vimentin and actin. Different growth patterns were observed in the different media, indicating that different signalling patterns must be operating in these cells depending upon the media in wh
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4

Liu, Ke, University of Western Sydney, of Science Technology and Environment College, and of Science Food and Horticulture School. "Role of second messengers in controlling growth patterns of corneal epithelial cells." THESIS_CSTE_SFH_Liu_K.xml, 2002. http://handle.uws.edu.au:8081/1959.7/387.

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The purpose of this thesis was to investigate mechanisms contolling the growth of corneal epithelial cells, particularly the intracellular signals involved with stratification compared with cellular migration and maturation. Buttons of epithelium were cultured in different culture media. The explants were monitored microscopically for their growth patterns and finally fixed and examined for cytokeratin, vimentin and actin. Different growth patterns were observed in the different media, indicating that different signalling patterns must be operating in these cells depending upon the media in wh
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Guo, Ying. "Actin contractility in corneal epithelial cells and regulation of the barrier integrity." [Bloomington, Ind.] : Indiana University, 2006. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3229600.

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Thesis (Ph.D.)--Indiana University, School of Optometry, 2006.<br>"Title from dissertation home page (viewed July 11, 2007)." Source: Dissertation Abstracts International, Volume: 67-08, Section: B, page: 4360. Adviser: Sangly Srinivas.
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6

Terry, S. J. "Identification of regulators and effectors of RhoGTPase signalling in corneal epithelial cells." Thesis, University College London (University of London), 2011. http://discovery.ucl.ac.uk/1306879/.

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Epithelial cells adhere to each other and are connected via a series of junctions. Tight junctions (TJs) are a specific type of junction consisting of heteromeric protein complexes that are linked to the actin cytoskeleton and are important in regulating paracellular permeability and cell polarity. RhoGTPases are small molecular switch proteins that are important regulators of the cytoskeleton and modulators of gene expression. RhoGTPases have thus been identified as being major signalling components associated with TJs. However little is known about how RhoGTPases are regulated to control jun
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7

Bhattacharya, Pradipta. "The corneal epithelium in health and disease." Thesis, Queensland University of Technology, 2022.

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The cornea is the anterior transparent layer of the eye, and understanding corneal epithelial morphology is valuable in monitoring ocular surface diseases. A meta-analysis showed that central corneal basal cell density and nerve parameters were reduced in diseases affecting the ocular surface including limbal stem cell deficiency. Using newly developed image analysis techniques it was observed that epithelial cell density was highest at the corneal nerve whorl region. A decrease in epithelial cell density was observed in eyes with conjunctival ultraviolet autofluorescence, i.e. with sunlight-i
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8

Barnard, Zeke. "Analyses of Cytokeratins and p63 Isoforms Expressed by Human Limbal Epithelial Cells." Thesis, Griffith University, 2005. http://hdl.handle.net/10072/367809.

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Cultivated autologous limbal epithelial grafts have shown promise as a valuable treatment to treat ocular surface injuries. The rationale for this therapy is that the limbus contains progenitor cells of the corneal epithelium and that when expanded and transplanted these cells help to restore a healthy epithelium. Nevertheless, this approach is still experimental and the optimal procedure for producing, grafting and assessing the presence of limbal stem cells in these grafts remains under development. The first results chapter examines the differences in cytokeratin expression between dono
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9

Shortt, A. J. "The limbal epithelial stem cell niche and its relevance to ex-vivo culture and transplantation of corneal limbal epithelial stem cells." Thesis, University College London (University of London), 2009. http://discovery.ucl.ac.uk/18929/.

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Transplantation of ex-vivo cultured limbal epithelial cells (LEC) is an established treatment for total limbal stem cell deficiency. However, this therapy has preceded the scientific understanding of limbal epithelial stem cells (LESC), the LESC niche and the biological mechanism that underpins it. This body of work tested the hypothesis that the LESC niche has a specialised structure and that an understanding of this may lead to improvements in outcomes and understanding of this therapy. The corneal limbus was investigated using 3D confocal microscopy, scanning electron microscopy, wholemount
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10

Yang, Juan. "Universal corneal epithelial-like cells derived from human embryonic stem cells in a defined, xeno-free, and albumin-free condition for cellularization of a corneal scaffold." Thesis, University of Macau, 2018. http://umaclib3.umac.mo/record=b3953938.

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11

Wang, Kemeng. "Role of potassium channel Kir4.1(KCNJ10) in the wound healing of human corneal epithelial cells." Thesis, Boston University, 2013. https://hdl.handle.net/2144/12245.

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Thesis (M.A.)--Boston University<br>The cornea, which is key to maintaining our normal vision by refracting light onto the lens and retina, as well as serving as a physical barrier to protect our eyes from the environment, contains epithelium tissue with one of the highest capacities for renewal and wound healing in the body. Although many studies have looked at the process of wound healing in corneal epithelium, most of them have focused on the various ligand-receptor growth factor signaling pathways, and few studies have been done to study the signaling and regulations of wound healing that
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12

Nili, Ahmadabadi Elham. "Development of a novel mesenchymal stromal cell (MSC) therapy for repairing the cornea." Thesis, Queensland University of Technology, 2018. https://eprints.qut.edu.au/122897/1/Elham_Nili%20Ahmadabadi_Thesis.pdf.

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This thesis has produced advances in our understanding of the biology and potential clinical application of stem cells to aid the treatment of patients with severe eye injuries. This research evaluated the therapeutic potential of a stem cell (called Mesenchymal Stromal Cells (MSCs)) isolated from the peripheral margin of the cornea, known as the limbus. Firstly, a method for routinely isolation and propagation of human limbal MSCs was optimized. Subsequently, the performance of those cells on a silk fibroin membrane was examined.
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13

He, Zhiguo. "Application de l'immunolocalisation à la recherche de la cellule souche endothéliale cornéenne humaine." Phd thesis, Université Jean Monnet - Saint-Etienne, 2011. http://tel.archives-ouvertes.fr/tel-00987968.

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Le contrôle de la transparence de la cornée dépend de l'intégrité de l'endothélium cornéen mono-stratifié qui est classiquement considéré dès la naissance, dépourvu de capacité de régénération chez l'homme. Dans des conditions pathologiques conduisant à la cécité par œdème cornéen, les pertes significatives en cellules endothéliales (CE) ne sont pas remplacée efficacement, ce qui signifie que ni de nouvelles CE provenant de cellules souches (CS), ni la division des cellules voisines des lésions ne peuvent contribuer à la régénération endothéliale. Toutefois, plusieurs travaux ont prouvé depuis
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14

Douvaras, Panagiotis. "Effects of age and Pax6 deficiency on mouse limbal stem cell function." Thesis, University of Edinburgh, 2010. http://hdl.handle.net/1842/4414.

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The conventional view for corneal epithelial maintenance suggests that a stem cell population found in the limbus (at the rim of the cornea) produces daughter cells, called transient amplifying cells, which migrate centripetally. This limbal stem cell (LSC) hypothesis was recently questioned and the alternative model suggests that stem cells are present throughout the corneal epithelium. The main aims of this thesis were to investigate whether age and Pax6 genotype affect LSC function. Previous work with X-inactivation mosaics revealed radial stripes of β-galactosidase-expressing cells in the
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15

Findlay, Amy Siobhan. "The molecular basis of epthelial cell migration : maintenance and repair of the ocular surface." Thesis, University of Aberdeen, 2015. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=228963.

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In vertebrates the cornea must maintain its transparency throughout adult life to ensure sight, and understanding the mechanisms underpinning corneal homeostasis are fundamental to developing new treatments to cure or prevent blindness. This study investigated the role the planar cell polarity pathway plays in the directed migration of adult corneal epithelial cells, in maintaining the homeostatic environment of the eye and during wound healing. RT-PCR confirmed, for the first time, the expression of multiple core PCP genes within human corneal epithelial (HCE) cells. Components of the PCP pat
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16

Mort, Richard Lester. "Stem cell function in the mouse corneal epithelium." Thesis, University of Edinburgh, 2007. http://hdl.handle.net/1842/8187.

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Limbal stem cells maintain the corneal epithelium through a process of clonal growth and ordered migration. In X-inactivation mosaic female mice, that express LacZ from one of their X-chromosomes, random clumps of LacZ-positive cells are seen in the cornea at 3-6 weeks of life. This pattern resolves between 6-10 weeks forming radial stripes thought to represent chords of clonally related, inwardly migrating cells. By measuring the number and width of stripes and correcting for the effects of different proportions of LacZ-positive cells, an estimate of the number of coherent stem cell clones ma
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17

Kolli, Satya Sai Prasad. "Corneal Epithelial Stem Cell Biology and its Therapeutic Application." Thesis, University of Newcastle Upon Tyne, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.506607.

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18

Kucerova, Romana. "Genetic control of corneal epithelial cell migration by Pax6." Thesis, University of Aberdeen, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.485667.

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Coordinated cell migration is essential for tissue regeneration and· development. During migration cells sense various directional cues from the surrounding environment, and intracellular mechanisms process this extracellular information resulting in appropriate vectorial cell movement. During corneal epithelial maintenance, cells migrate centripetally from the limbal region towards the centre of the cornea. This centripetal movement is genetically controlled by Pax6 (Collinson et aI., 2004), one of the master genes in eye development (Kozmik, 2005). The guidance cues and cellular mechanism
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19

Alshammari, Fehaid Salem L. "Mathematical modelling of human corneal oxygenation and cell kinetics in corneal epithelial wound healing." Thesis, Queensland University of Technology, 2016. https://eprints.qut.edu.au/92835/1/Fehaid%20Salem%20L_Alshammari_Thesis.pdf.

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Healthy transparent cornea depends upon the regulation of fluid, nutrient and oxygen transport through the tissue to sustain cell metabolism and other critical processes for normal functioning. This research considers the corneal geometry and investigates oxygen distribution using a two-dimensional Monod kinetic model, showing that previous studies make assumptions that lead to predictions of near-anoxic levels of oxygen tension in the limbal regions of the cornea. It also considers the comparison of experimental spatial and temporal data with the predictions of novel mathematical models with
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20

Masuda, Sayuri. "Angulin/LSR defines cell corners for tricellular tight junction formation in epithelial cells." Kyoto University, 2011. http://hdl.handle.net/2433/142056.

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21

Sagga, Nada A. "Dynamics of limbal and conjunctival stem cell activity during ocular surface maintenance." Thesis, University of Aberdeen, 2017. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=235418.

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Corneal degenerative diseases and opacity are leading causes of corneal impairment and blindness worldwide. Like many epithelial tissues, the constant renewal of transparent corneal epithelial cells is essential for a lifelong healthy cornea and optimal vision. The limbus (the boundary between the cornea and the conjunctiva) is believed to be the site that harbours adult stem cells responsible for corneal maintenance and repair after injury, referred to as limbal epithelial stem cells (LESCs). In the basal limbal epithelium, an active LESC subset divides to yield progenitor cells that migrate
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22

Bentley, Adam James. "Characterisation and replication of the corneal epithelial stem cell niche." Thesis, Lancaster University, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.514445.

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23

McBain, Vikki A. "Small applied electric fields, growth factors and corneal epithelial cell behaviour." Thesis, University of Aberdeen, 1999. http://digitool.abdn.ac.uk/R?func=search-advanced-go&find_code1=WSN&request1=AAIU123848.

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Wounding of the cornea generates lateral electric fields (EFs) and initiates the expression of hepatocyte growth factor (HGF) and keratinocyte growth factor (KGF; Chiang et al., 1992; Wilson et al., 1999a). Therefore, these biologically generated EFs and endogenous growth factors may be of particular significance during wound healing. In the presence of an EF (150 mV/mm) cultured corneal epithelial cells (CECs) oriented perpendicular, directed cathodally and migrated at an enhanced rate. The induction times, induction thresholds and response patterns for these behaviours in increasing field st
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24

Ainscough, Sarah Louise. "Improved strategies for the cultivation of human limbal epithelial (HLE) grafts." Thesis, Queensland University of Technology, 2008. https://eprints.qut.edu.au/18575/1/Sarah%20Ainscough%20Thesis.pdf.

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The limbal stem cell population is located in the limbal junctional zone between the cornea and the conjunctiva, and is responsible for maintaining the corneal epithelium. Damage to the limbal stem cell population results in a condition known as limbal stem cell deficiency (LSCD), which is characterised by conjunctivalisation of the cornea, visual impairment and persistent irritation. To treat LSCD, an alternative source of human limbal epithelial (HLE) cells must be transplanted back onto the diseased cornea. Limbal tissue grafts have had a moderate degree of success. However, autologous graf
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Ainscough, Sarah Louise. "Improved strategies for the cultivation of human limbal epithelial (HLE) grafts." Queensland University of Technology, 2008. http://eprints.qut.edu.au/18575/.

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The limbal stem cell population is located in the limbal junctional zone between the cornea and the conjunctiva, and is responsible for maintaining the corneal epithelium. Damage to the limbal stem cell population results in a condition known as limbal stem cell deficiency (LSCD), which is characterised by conjunctivalisation of the cornea, visual impairment and persistent irritation. To treat LSCD, an alternative source of human limbal epithelial (HLE) cells must be transplanted back onto the diseased cornea. Limbal tissue grafts have had a moderate degree of success. However, autologous graf
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Chandler, Heather Lynn. "Epithelial-mesenchymal transition in the anterior segment of the eye." Columbus, Ohio : Ohio State University, 2006. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1154533588.

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Fok, Elsie. "Advanced stem cell delivery systems for the treatment of corneal epithelial limbal stem cell deficiency." Thesis, University of Brighton, 2014. https://research.brighton.ac.uk/en/studentTheses/134e3b10-9910-40d6-bec8-8a7481b9e67e.

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Limbal stem cell deficiency (LSCD) can be treated successfully using ex vivo limbal epithelial stem cells (LESC) derived from cadaveric donor tissue. However, shortages in such tissues and graft rejection, resulting from inflammation, are persistent issues. The purpose of this study was to optimize current culturing techniques used for LESC transplant tissue, considering expansion and cryopreservation issues surrounding the establishment of a stem cell bank. In addition, a novel anti-inflammatory biomimetic peptide was investigated to address issues surrounding amnion and steroid use in LESC t
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Dziasko, M. A. "Localisation of corneal epithelial progenitors and characterization of cell-cell interactions in the human limbal stem cell niche." Thesis, University College London (University of London), 2016. http://discovery.ucl.ac.uk/1472700/.

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The cornea, the transparent tissue located at the front of the eye, is a highly specialized tissue that transmits and refracts light onto the retina. Maintenance of the corneal epithelium relies on a population of limbal epithelial stem cells (LESCs) that maintain transparency of the ocular surface that is essential for vision. Despite great advances in our understanding of ocular stem cell biology over the last decade, the exact location of the LESC niche remains unclear. After observing a high population of basal epithelial cells expressing stem cell markers within the previously identified
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Panzica, Domenico Alessio. "The roles of planar cell polarity signalling in maintaining the adult corneal epithelium." Thesis, University of Aberdeen, 2015. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=227224.

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Cells of the stratified adult corneal epithelium undergo centripetal migration throughout adult life from the edge of the cornea to the centre. To date nothing is known about the mechanism underpinning the oriented cellular migration. Failure to replenish apoptotic cells lost by desquamation from the superficial layer of the corneal epithelium leads to severe pathological conditions that may result in blindness. In this study we investigated the role of planar cell polarity (PCP) core proteins as the guidance cue for centripetal migration in the cornea. Cre-mediated conditional deletion of flo
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Secker, G. "Characterisation of the corneal epithelium and stem cell niche using models of PAX6 deficiency." Thesis, University College London (University of London), 2009. http://discovery.ucl.ac.uk/17305/.

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The corneal epithelium is continuously renewed by a population of stem cells that reside in the corneo-scleral junction, otherwise known as the limbus. These limbal epithelial stem cells (LESC) are imperative for corneal maintenance, with deficiencies resulting in in-growth of conjunctival cells, neovascularisation of the corneal stroma and eventual corneal opacity and visual loss. One such disease that has traditionally been thought to be due to LESC deficiency is aniridia, a pan-ocular congenital eye disease due to PAX6 heterozygosity. Corneal changes or aniridia related keratopathy (ARK) se
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Hammadi, Shumoos T. H. "Novel medical imaging technologies for processing epithelium and endothelium layers in corneal confocal images. Developing automated segmentation and quantification algorithms for processing sub-basal epithelium nerves and endothelial cells for early diagnosis of diabetic neuropathy in corneal confocal microscope images." Thesis, University of Bradford, 2018. http://hdl.handle.net/10454/16924.

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Diabetic Peripheral Neuropathy (DPN) is one of the most common types of diabetes that can affect the cornea. An accurate analysis of the corneal epithelium nerve structures and the corneal endothelial cell can assist early diagnosis of this disease and other corneal diseases, which can lead to visual impairment and then to blindness. In this thesis, fully-automated segmentation and quantification algorithms for processing and analysing sub-basal epithelium nerves and endothelial cells are proposed for early diagnosis of diabetic neuropathy in Corneal Confocal Microscopy (CCM) images. Firstly,
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Miri, Ammar. "Corneal epithelial stem cell deficiency : in vivo and in vitro analysis of diagnostic features and treatment outcomes." Thesis, University of Nottingham, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.601801.

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Several clinical and laboratory studies suggest that the niche for corneal epithelial stem cells is located in the corneoscleral limbus. Of particular interest are the palisades of Vogt (POV), which are a series of fibrovascular palisade like structures found predominantly along the superior and inferior limbus. The study was designed to use a relatively new and powerful tool, the laser in vivo confocal microscopy (Rostock corneal module confocal microscope) of scanning laser ophthalmoscope, ) HRTII; to evaluate in details normal anatomical features of the limbus and establish diagnostic featu
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Heydenrych, Leonard Goussárd. "Eviscerated corneas as tissue source for ex vivo expansion of limbal epithelial cells on platelet-rich plasma gels." Master's thesis, University of Cape Town, 2016. http://hdl.handle.net/11427/22923.

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Purpose/Aim of the study: To assess if corneal epithelium can be cultured ex-vivo from corneas eviscerated due to irretrievable trauma, according to a cell culture method which made use of autologous platelet-rich plasma (A-PRP) as culture substrate. To compare corneal epithelium cultured ex vivo from corneas eviscerated following trauma using A-PRP combined with DMEM (Dulbecco's modified Eagles medium), versus DMEM alone. Materials and Methods: This was a laboratory case controlled study of human corneal cells cultured in a mixture of A-PRP and DMEM, versus DMEM alone from 6 eviscerated corne
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Bray, Laura Jane. "Evaluation of fibroin-based scaffolds for ocular tissue reconstruction." Thesis, Queensland University of Technology, 2012. https://eprints.qut.edu.au/52665/1/Laura_Bray_Thesis.pdf.

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The epithelium of the corneolimbus contains stem cells for regenerating the corneal epithelium. Diseases and injuries affecting the limbus can lead to a condition known as limbal stem cell deficiency (LSCD), which results in loss of the corneal epithelium, and subsequent chronic inflammation and scarring of the ocular surface. Advances in the treatment of LSCD have been achieved through use of cultured human limbal epithelial (HLE) grafts to restore epithelial stem cells of the ocular surface. These epithelial grafts are usually produced by the ex vivo expansion of HLE cells on human donor amn
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Henkel, Tassilo. "Synthese und Charakterisierung von Limbusepithel-Amnion-Transplantaten aus langzeitorgankonservierten Hornhäuten und kryokonservierten Amnionmembranen." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2011. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-63630.

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In dieser Arbeit wurden Methoden entwickelt und verglichen, um aus Corneoskleralringen langzeitorgankonservierter Hornhäute und intakten, kryokonservierten Amnionmembranen Limbusepithel-Amnion-Transplantate herzustellen. Als erfolgreichste Kultivierungsmethode stellte sich hierbei signifikant die Explantat-Technik mit nach unten gerichtetem Limbusepithel heraus. Hier konnte eine Auswachsrate von 42 % erzielt werden. Es wurde weiterhin gezeigt, dass das ausgewachsene, mehrschichtige Limbusepithel proliferationsfähige TACs (Transient Amplifying Cells) enthält. Weiterhin konnten mittels Regressi
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Rovere, Maria. "Reconstruction cornéenne : traitement des déficiences en cellules souches limbiques totales et bilatérales associées ou non à une atteinte du stroma." Thesis, Lyon, 2018. http://www.theses.fr/2018LYSE1263.

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Certaines brûlures oculaires graves ou d'autres pathologies oculaires rares peuvent être associées à une perte totale de cellules souches épithéliales de la cornée (DCSL), ce qui conduit à une opacification de la cornée par invasion de la conjonctive. Lorsque la DCSL est totale et bilatérale, le limbe controlatéral n'est pas disponible pour la greffe de limbe autologue ou la culture de cellules souches autologues limbiques et la transplantation allogénique de la cornée est impossible car toujours rejetée en raison de la néovascularisation. Une thérapie innovante testée avec succès au sein de n
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Ferraris, Corinne. "Pluripotentialité des kératinocytes épidermiques et cornéens chez les mammifères." Grenoble 1, 1994. http://www.theses.fr/1994GRE10090.

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Afin d'etudier les potentialites de l'epiderme et de l'epithelium corneen a former des annexes cutanees telles que les follicules pileux ainsi que les glandes sebacees et sudoripares, des recombinaisons heterotopiques heterospecifiques ont ete realisees puis greffees sur la souris nude. L'origine des cellules constituant ces structures differenciees, a ete identifiee par hybridation in situ avec une sonde alu reconnaissant l'adn humain, et par marquage differentiel des noyaux de lapin et de souris a l'aide du fluorochrome de hoechst. L'epiderme embryonnaire est capable de former des ensembles
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范姜益園. "Phenotype of corneal epithelial cells on chitosan membrane." Thesis, 2006. http://ndltd.ncl.edu.tw/handle/02041687083082777131.

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"Anatomical and functional analysis of microRNAs in human cornea epithelial progenitor cells." Thesis, 2010. http://library.cuhk.edu.hk/record=b6074820.

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By performing microRNA microarrays to globally detect any novel miRNAs in the limbus, eleven microRNAs (hsa-miR-136, hsa-miR-373*, hsa-miR-150, hsa-miR-143, hsa-miR-455, hsa-miR-145, hsa-miR-381, hsa-miR-224, hsa-miR-338, hsa-miR-154, hsa-miR-377) were found to be upregulated while two microRNAs (hsa-miR-122a and hsa-miR-425-3p) were identified as downregulated by more than 2 folds. Among these, hsa-miR-143 and hsa-miR-145 were distingushed to be the most significantly up-regulated limbal miRNAs. Individual assessement of the microarray results of a recently reported stem cell specific microRN
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McKie, George A. "The effect of nanoscale topography on corneal epithelial cells." 2004. http://catalog.hathitrust.org/api/volumes/oclc/61502514.html.

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Hassan, E., P. Deshpande, F. Claeyssens, Stephen Rimmer, and S. MacNeil. "Amine functional hydrogels as selective substrates for corneal epithelialization." 2014. http://hdl.handle.net/10454/10459.

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No<br>The aim of this study was to develop a synthetic hydrogel to act as a corneal substitute capable of selectively supporting the adhesion and proliferation of limbal epithelial cells (LECs) while inhibiting growth of limbal fibroblasts. Deficiency of LECs causes conjunctival epithelial cells to move over the cornea, producing a thick scar pannus. Unilateral defects can be treated using LEC cultured from the unaffected eye, transplanting them to the affected cornea after scar tissue is removed. The underlying wound bed is often damaged, however, hence the need to develop a corneal inlay to
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Chu, Yen-Chang, and 褚晏彰. "Stiffness of Substrate Affects Corneal Epithelial Cells Migration in Electric Fields." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/57122345459068739762.

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碩士<br>國立臺灣大學<br>醫學工程學研究所<br>98<br>Cell migration involves in many fields, such as wound healing, tumor metastasis, organ development, immune response and morphological change. Cell migration is affected by many factors, such as electric field, rigidity of the substrate, and chemical gradient. Amniotic membrane (AM) is commonly used to treat persistent corneal injuries. In an attempt to understand mechanisms behind this enhancement of the healing process, bovine corneal epithelial cells were used to examine cell migration on the various substrates. External electric field was applied to simulat
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Tsai, Tzu-Yun, and 蔡紫筠. "The cytotoxicity and mechanism of fluoroquinolones on human corneal epithelial cells." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/10253835519971275999.

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碩士<br>臺灣大學<br>臨床醫學研究所<br>98<br>Bacterial keratitis is a common ocular infection and a leading cause of ocular morbidity and blindness worldwide. However, according to our previous report regarding 10-year experience of microbial keratitis at the National Taiwan University Hospital, contact lens-related pseudomonal keratitis was the most common form of microbial keratitis in Taiwan. Effective topical therapy, using fortified antimicrobials or monotherapy commercial ophthalmic preparation selected based on the results of diagnostic corneal smears and cultures, is essential for management of pati
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"Human umbilical cord lining epithelial cells with stem cell-like properties: an adjunct to skin regeneration." 2013. http://library.cuhk.edu.hk/record=b5549751.

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皮膚是人體最大的器官，具有多種功能，其中最重要的功能之一就是作為身體內部和外界環境之間的的保護屏障。完整地修復這一保護屏障是創傷癒合和組織再生領域的一個重要內容。本論文探討了人類臍帶被覆上皮細胞 (cord lining epithelial cells, CLECs)作為一種幹細胞來源，可用于表皮重建的潛能.<br>本論文的第二章對CLECs的體外分離和增殖進行了詳細地描述。這一類細胞具有較長的染色體端粒，較高的增殖潛能和傳代能力。同時，它們表達上皮幹細胞和多能性幹細胞的標誌性表面抗原。它們還具有多種分化潛能，包括成脂、成骨和成軟骨。然而當皮下異種移植後，它們並不會形成畸胎瘤。<br>本論文的第三章對CLECs的免疫特性進行了評估。結果顯示CLECs不但具有低免疫原性，還具有免疫調節功能。它們表達典型性的一型主要組織相容性複合體(MHC class I)，即人白細胞ABC抗原(HLA-ABC)，但不表達典型性的二型主要組織相容性複合體(MHC class II)，即人白細胞DR抗原(HLA-DR)。它們同時還表達非典型性的MHC class I, 包括人白細胞G抗原和人白細胞E 抗原(HLA-G和HLA-E), 但不表達共激分子(CD40, CD80和CD86)。此外，體外檢測還發現它們表達適度的促炎/抗炎細胞因子和大量的生長因子.<br>本論文的第四章對CLECs在表皮重建應用
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Liu, Kuan-Ting, and 劉冠廷. "Effect of ferulic acid on reactive oxygen species induced apoptosis in corneal epithelial cells." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/11405286390992266909.

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碩士<br>國立陽明大學<br>解剖學及細胞生物學研究所<br>101<br>In recent years, ROS was reported that induced associated with corneal diseases by oxidative stress. The oxidative stress induced cell apoptosis of corneal epithelium could lead to impaired vision and has the risk of blindness. A major goal is to reduce the damage induced by ROS. Given that ferulic acid has a great antioxidant activity to eliminate ROS and to suppress apoptosis on varied cell types. We hypotheses that ferulic acid may play a therapeutic role in reducing corneal diseases. Establishment of H2O2-damaged cell model and determination of the sa
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Cheng, Shao-Hui, and 鄭劭蕙. "Evaluation of Epitheliotrophic Capacity of Four Different Blood Derivatives on Bovine Corneal Epithelial cells." Thesis, 2007. http://ndltd.ncl.edu.tw/handle/99659962085711949174.

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碩士<br>國立臺灣大學<br>獸醫學研究所<br>95<br>PURPOSE： Human serum eye drops have been successfully used in treatment of severe ocular surface disorders and enhancement of corneal wound healing. Umbilical cord serum is effective in treatment of dry eye and persistent corneal epithelial defects. Fresh frozen plasma has not yet been tested for use as eye drops in patients, although it is easily available as quality-controlled products from blood banks. Fresh frozen plasma or umbilical cord serum could be used for substituting human serum when the source of human serum lacks. The use of fetal bovine serum (FBS
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WANG, DER-YUAN, and 王德原. "Characterization and Identification of Limbal Epithelial Stem Cells in a Tissue-Engineered Rabbit Corneal Model." Thesis, 2005. http://ndltd.ncl.edu.tw/handle/29736528650469859924.

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博士<br>長庚大學<br>基礎醫學研究所<br>93<br>Severe damage to the limbal epithelium due to chemical/thermal burns, virus infection and other pathological events may lead to loss of the limbal epithelial stem cells. Limbal epithelial stem cell deficiency lead to chronic inflammation and vascular invasion of the cornea eventually and cause functional blindness. The autologous and allogenic transplantation of limbal epithelial cells expanded on human amniotic membrane have been introduced to improve the outcome of ocular surface reconstruction in limbal deficient eyes. However, the identification of limbal
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Ho, Jennifer Hui-Chun, and 何慧君. "Elucidation of the anti-apoptotic mechanisms of exogenous thymosin beta-4 on human corneal epithelial cells." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/67315090189606566067.

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博士<br>國立陽明大學<br>生物藥學研究所<br>96<br>Cornea surface, the first-line defense of the eye, is covered with corneal epithelial cells which functionally protect corneal stroma from injury and maintain the transparency of stroma. Apoptosis is the ultimate pathomechanism of many corneal diseases including dry eye, mechanical or chemical injury, ultraviolet ray injury, contact lens-induced corneal edema and infection. Thymosin beta-4 (Tb4) is a ubiquitous peptide consisting of 43 amino acids that has pleiotropic functions including an anti-apoptotic effect on corneal epithelial cells when exogenously admi
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Tanti, Nicole-Christina. "Investigating The Impact of Multipurpose Solutions Released From Silicone Hydrogel Lenses on Corneal Epithelial Cells, in vitro." Thesis, 2009. http://hdl.handle.net/10012/4985.

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Cytotoxicity of Multi-Purpose Solutions (MPS) is commonly tested on cells using diluted MPS or extracts from MPS soaked contact lenses. There is evidence that lens type will affect uptake and release of compounds contained in MPS. To assess the cytotoxicity of agents contained in MPS that would be released by contact lens, an in vitro “onlay” model was used, whereby MPS soaked silicone hydrogel lenses were directly set onto a confluent monolayer of corneal cells. Chapter 4 describes the impact of MPS released from contact lenses on immortalized human corneal epithelial cells. MPS-soaked lens
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Chiu, Chih-Shen, and 邱志陞. "Studies on the effect of chitosan membranes and chitosan nanoparticles on the behavior of corneal epithelial cells." Thesis, 2005. http://ndltd.ncl.edu.tw/handle/82967286348683783270.

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碩士<br>國立臺灣大學<br>醫學工程學研究所<br>93<br>In recent years, amniotic membranes transplantation is the most important advancement of treatment modality to treat ocular surface diseases. However, there are a lot of flaws for amniotic membranes transplantation. For example, the ethic issue and contamination of amniotic membrane make us to seek a new material to replace the usage of amniotic membrane. The purpose of this project is to evaluate the possibility of replacement of amnitoic membrane with chitosan membrane, which is a biocompatible materials used in many fields of biomedical science. We cultivat
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