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Rozprawy doktorskie na temat „Cough”

Autor: Grafiati

Data publikacji: 4 czerwca 2021

Data aktualizacji: 25 lipca 2025

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1

Khalid, Saifudin. "Inhalational cough challenges in the assessment of cough." Thesis, University of Manchester, 2013. https://www.research.manchester.ac.uk/portal/en/theses/inhalational-cough-challenges-in-the-assessment-of-cough(8788e20e-3f76-4600-bdc1-e9bee31b5c01).html.

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Introduction: Cough is the commonest reason for which medical advice is sought. In assessment of chronic cough and in developing anti-tussive medications, inhalational cough challenges with capsaicin and citric acid are commonly employed. However the ability of these inhalational cough challenges to distinguish health and disease is not clear and it is not known which end point is best in making such assessments. Methods: Subjects belonging to five different categories (healthy volunteers, subjects with COPD, asthma, healthy current smokers and chronic cough) were compared with each another by

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2

Hassan, H., Gayatri Jaishankar, and Demetrio Macariola. "The "Non" Whooping Cough." Digital Commons @ East Tennessee State University, 2020. https://dc.etsu.edu/etsu-works/8861.

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3

Pillay, Victoria. "A systematic review of the symptomatic treatment of the cough in whooping cough." Master's thesis, University of Cape Town, 2002. http://hdl.handle.net/11427/8789.

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Includes bibliographical references.<br>Background: There are between 20 - 40 million cases of whooping cough annually world-wide, 90% of which occur in developing countries, resulting in an estimated 200 - 300 O00 fatalities each year. Much of the morbidity is due to the paroxysmal cough. Corticosteroids, salbutamol (a β₂- adrenergic stimulant), and pertussis-speciﬁc immunoglobulin have been proposed as standard treatment for the cough. Antihistamines have also been administered. No systematic review of the effectiveness of any of these interventions or others has been performed. Objective: i

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4

Mason, Nicholas. "Mechanisms of altitude-related cough." Doctoral thesis, Universite Libre de Bruxelles, 2012. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/209711.

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The original work presented in this thesis investigates some of the mechanisms that may be responsible for the aetiology of altitude-related cough. Particular attention is paid to its relationship to the long recognised, but poorly understood, changes in lung volumes that occur on ascent to altitude. The literature relevant to this thesis is reviewed in Chapter 1.<p><p>Widespread reports have long existed of a debilitating cough affecting visitors to high altitude that can incapacitate the sufferer and, on occasions, be severe enough to cause rib fractures (22, 34, 35). The prevalence of cough

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5

Dixon, Nicola Jane. "The psychology of chronic cough." Thesis, University of Hull, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.395657.

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6

Yousaf, Nadia. "Cough in health and disease." Thesis, University of Leicester, 2013. http://hdl.handle.net/2381/28114.

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Cough is a common symptom of both acute and chronic respiratory illness. It is poorly understood and treatment options are sparse. One reason is that there are few validated objective measures of cough frequency and severity. In this thesis I have further validated the Leicester Cough Monitor, an automated cough detection system capable of detecting coughs over 24 hours. I have demonstrated that automated cough numbers were similar to those derived from the gold standard of manual counting in healthy adults and in patients with respiratory disease. Cough frequency was then measured using the L

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7

Kelsall, Angela. "Respiratory physiology in chronic cough." Thesis, University of Manchester, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.491479.

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Introduction: Varying methods of cough quantification have been used to describe cough frequency, although there is no consensus which method best relates to subjective rating of cough. With increased availability of semi-automated cough recording devices, the capability to carryout anti-tussive studies is greatly increased. However, there is no data available describing the magnitude of change in cough frequency necessary to provide therapeutic benefit. Female patients are over represented in specialist cough clinics. There is little data describing pulmonary function and airway inflammation

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8

Marsden, Paul Anthony. "Cough, asthma and airways inflammation." Thesis, University of Manchester, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.516825.

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Rationale Cough is an important symptom in asthma. In addition, cough is both troublesome to patients and may be important in the development of more severe disease. Moreover, it is a key symptom in the diagnosis of asthma, according to international guidelines. Little is known regarding the mechanism of cough in asthma. Until now, subjective measures of cough have been used in mechanistic and therapeutic studies relating to both cough in asthma and chronic cough. There is no published literature documenting cough rates in asthma or the relationship between cough rates and both subjective meas

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9

McGuinness, Kevin. "Cough detection. a physiological approach." Thesis, University of Manchester, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.528494.

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10

Elghamoudi, Deblej. "Objective cough monitoring in children." Thesis, University of Manchester, 2018. https://www.research.manchester.ac.uk/portal/en/theses/objective-cough-monitoring-in-children(e3d822f0-d1b1-4056-8f98-1b6dd634c47f).html.

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Background: Cough is extremely common in childhood and a tool to objectively measure cough frequency would be clinically beneficial. To date paediatric cough monitoring systems have relied on manual cough counting which is time consuming and costly. The VitaloJAKâ¢ (Vitalograph, UK) is a custom built 24hr semi-automated cough monitoring device that has been used successfully to quantify cough in adults. This thesis consists of a series of studies using the VitaloJAKâ¢ monitor system in children. Methods: Firstly, we tested the feasibility of using the VitaloJAKâ¢ for 24 hr cough recordin

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11

Blackwelder, Reid B. "Primary Care Approach to Cough." Digital Commons @ East Tennessee State University, 2003. https://dc.etsu.edu/etsu-works/6994.

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12

Lee, Kai Kong. "Objective measures of cough severity." Thesis, King's College London (University of London), 2014. http://kclpure.kcl.ac.uk/portal/en/theses/objective-measures-of-cough-severity(5fd78f7a-7458-41ec-8d58-c804b3d483b6).html.

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Cough is a common complaint that results in significant morbidity and impairment in quality of life. The assessment of cough severity is central to the diagnosis and clinical management of cough. The aim of this thesis was to evaluate objective measures of cough frequency and cough intensity in patients with acute and chronic cough. 24-hour cough frequency was investigated in a longitudinal observational study of 33 healthy subjects with acute cough. At baseline, 24-hour cough frequency was elevated and was associated with impaired health related quality of life. Cough frequency improved signi

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13

Kastelik, Jack A. "Investigation and assessment of chronic cough." Thesis, University of Hull, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.402480.

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14

Kelly, Helana Ellen. "The effect of titrated fentanyl on cough response in healthy participants." Thesis, University of Canterbury. Department of Communication Disorders, 2014. http://hdl.handle.net/10092/9158.

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Background: One population prone to aspiration pneumonia and impaired cough is the postoperative patient. Postoperative pneumonia is the third most common complication among surgical patients after urinary tract and wound infections (Wren, Martin, Yoon, & Bech, 2010). A patient who has their surgical course complicated by aspiration pneumonia has increased morbidity, increased length of hospital stay and places greater demands on the health system. Mortality rates are cited as high as 70% (Wren, et al., 2010). Despite the prevalence of postoperative pneumonia and the high morbidity and mortali

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15

Haji, Sadeghi Mahboobeh. "The emerging role of the eosinophil and its measurement in chronic cough : airway inflammation in chronic cough." Thesis, University of Hull, 2017. http://hydra.hull.ac.uk/resources/hull:16543.

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Although the aetiology of chronic cough in guidelines is clearly stated as asthma and related syndromes, gastro-oesophageal reflux disease, and upper airways disease, the inflammatory mechanisms underlying these conditions differ. Recent studies on asthma have increasingly focused on its molecular phenotypes instead of clinical characteristics. Predominantly in this thesis I hypothesize that by dividing cough patients into the clinical characteristics of eosinophilic and neutrophilic groups will enhance our ability to recognise the type of airway inflammation, and consequently will lead us to

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16

Torvaldsen, Siranda. "The epidemiology and prevention of pertussis in Australia." Thesis, The University of Sydney, 2001. http://hdl.handle.net/2123/808.

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Pertussis (whooping cough) remains an important public health problem in Australia. Although mortality and morbidity from pertussis declined dramatically following the introduction of mass vaccination programs in 1953, the level of morbidity remains unacceptably high for a vaccine-preventable disease. Aims and methods The primary aims of this thesis were (i) to ascertain the epidemiology of pertussis in Australia between 1993 and 2000 by analysing and interpreting sources of routinely collected data on pertussis; and (ii) to examine the effectiveness of vaccination against pertussis in a

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17

Torvaldsen, Siranda. "The epidemiology and prevention of pertussis in Australia." University of Sydney. Paediatrics and Child Health, 2001. http://hdl.handle.net/2123/808.

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Pertussis (whooping cough) remains an important public health problem in Australia. Although mortality and morbidity from pertussis declined dramatically following the introduction of mass vaccination programs in 1953, the level of morbidity remains unacceptably high for a vaccine-preventable disease. Aims and methods The primary aims of this thesis were (i) to ascertain the epidemiology of pertussis in Australia between 1993 and 2000 by analysing and interpreting sources of routinely collected data on pertussis; and (ii) to examine the effectiveness of vaccination against pertussis in a

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18

Birring, Surinder S. "Clinical and laboratory features of chronic cough." Thesis, University of Leicester, 2004. http://hdl.handle.net/2381/10329.

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Chronic cough is a common presenting symptom to both general practice and respiratory clinics and in up to 20% of patients, the cough remains unexplained after extensive investigation and treatment trials. In this thesis, we have shown that patients with idiopathic chronic cough are predominantly female, have an onset of cough in middle age and have a high prevalence of organ specific autoimmune disease, particularly hypothyroidism. We found that idiopathic chronic cough is associated with a bronchoalveolar lavage lymphocytosis and have suggested that this is due to homing of activated lymphoc

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19

Hutchinson, Nicola-Xan. "Studies of cough in Idiopathic Pulmonary Fibrosis." Thesis, Cardiff University, 2016. http://orca.cf.ac.uk/94471/.

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A dry cough is a common symptom described in patients with IPF and impairs quality of life. The exact mechanisms causing cough in IPF remain unclear, however there is evidence that altered cough neurophysiology and sensitisation plays a roleY IPF patients have an enhanced cough reflex sensitivity to the inhalation of capsaicin. It was hypothesised that IPF patients have increased airway expression of the capsaicin receptor TRPVF1 and a coFexpressed receptor TRPAF1. Bronchial biopsies were obtained in 16 IPF patients, 11 chronic cough patients and 8 controls. Quantitative PCR was used to detect

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20

Toop, Leslie John. "Cough sound analysis in children with asthma." Thesis, University of Bristol, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.361104.

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21

Aleixo, de Matos SeÌrgio Guilherme. "Automatic detection and analysis of cough sounds." Thesis, University of Leicester, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.437913.

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22

Iwata, Toshiyuki. "Mechanical stimulation by postnasal drip evokes cough." Kyoto University, 2016. http://hdl.handle.net/2433/215415.

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23

Rafiq, Muhammad. "Mechanically assisted cough in motor neurone disease." Thesis, University of Sheffield, 2014. http://etheses.whiterose.ac.uk/6875/.

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Motor Neurone Disease (MND) is a disabling and inevitably fatal disease, usually with a life expectancy of 2-3 years from symptom onset. It is characterised by progressive wasting and weakness in bulbar, limb and respiratory muscles. There is no cure and treatment is mainly symptomatic. Neuromuscular respiratory failure, with or without a chest infection, is the commonest cause of death in MND patients. It has been shown that supporting respiratory function with non-invasive ventilation, improves survival and quality of life despite progression of the disease. The patients with respiratory mus

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24

Monroe, Margaret Delia. "Citric acid inhalation cough challenge: Establishing normative data." Thesis, University of Canterbury. Communication Disorders, 2010. http://hdl.handle.net/10092/4149.

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One of the most elusive challenges in the diagnosis and treatment of dysphagia is the reliable identification of silent aspiration (aspiration in the absence of cough). The citric acid inhalation cough challenge offers potential for aiding in identification of silent aspiration; however clinical application of this technique is currently problematic due to an absence of normative data. Therefore, this study aimed to establish a normative data set for the Citric- Acid Inhalation Cough Challenge, as administered with facemask method. 80 healthy subjects will participate in this study, constituti

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25

Piyawong, Wirawan. "Spatio-temporal numerical modelling of whooping cough dynamics." Thesis, Brunel University, 2001. http://bura.brunel.ac.uk/handle/2438/6626.

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The SIR (Susceptible/Infectious/Recovered) whooping cough model involving nonlinear ordinary differential equations is studied and extended to incorporate (i) diffusion (ii) convection and (iii) diffusion-convection in one-space dimension. Firstand second-order finite-difference methods are developed to obtained the numerical solutions of the ordinary differential equations. Though implicit in nature, with the resulting improvements in stability, the methods are applied explicitly. The proposed methods are economical and reliable in comparison to classical numerical methods. When extended to t

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26

McFarlane, Mary. "A Pilot Study of Change in Laryngeal Cough Threshold Sensitivity and PAS(Penetration Aspiration Scale) Score Within the Acute Stage." Thesis, University of Canterbury. Speech and language science, 2013. http://hdl.handle.net/10092/10734.

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Background: Cough Reflex Testing (CRT) has been shown to be useful in the challenging task of identifying silent aspiration (aspiration without a cough response). With the emergence of the routine clinical use of CRT in the acute stroke population, the following clinical conundrum often arises: Does passing a previously failed CRT mean the risk of silent aspiration has resolved? The purpose of this study was to evaluate the association between change in laryngeal cough threshold sensitivity and change in PAS (Penetration Aspiration Scale) score within the acute stage post-stroke. Methods: This

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27

Cheung, Yung-yan Terence. "Whooping cough : are we seeing the reemergence of the infection in Hong Kong? /." Click to view the E-thesis via HKUTO, 2005. http://sunzi.lib.hku.hk/hkuto/record/b39724049.

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28

Venkatesan, Priya. "Modulation of airway neural control and the cough reflex." Thesis, Imperial College London, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.326081.

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29

Polley, L. "The role of novel Ion Gates channels in cough." Thesis, Queen's University Belfast, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.517507.

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Johnston, I. D. A. "The current severity and longterm sequelae of whooping cough." Thesis, University of Cambridge, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.605661.

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Fowles, Helen Elizabeth. "An investigation into the mechanism of inhalational cough challenge." Thesis, University of Hull, 2018. http://hydra.hull.ac.uk/resources/hull:16542.

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Chronic cough is a common problem. Historically treatments have focussed on treating underlying physiological causes. More recently an overarching theory of cough hypersensitivity syndrome has developed. In-vitro models of cough have not successfully translated into human studies. Testing the cough reflex in humans via inhalational cough challenge has been utilised since the 1950s. The mechanisms of cough challenge are poorly understood. This thesis sets out to investigate these mechanisms further in three different experiments. By altering pH in a citric acid challenge and measuring cough res

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32

Harle, Amelie. "The characterisation and treatment of cough in lung cancer." Thesis, University of Manchester, 2015. https://www.research.manchester.ac.uk/portal/en/theses/the-characterisation-and-treatment-of-cough-in-lung-cancer(f0ba551d-c7c8-4b5c-8d56-9b0c32d6d3ab).html.

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Cough in lung cancer (LC) is a significant unmet need. There are no evidence-based effective antitussives for its treatment and a lack of well-designed trials incorporating validated cough assessment tools and placebo controls. There is little research on its underlying mechanisms, perhaps with the assumption that it is simply 'due to the cancer'. Therefore, we have sought to characterise cough in terms of its severity, impact on quality of life, frequency and prevalence using LC specific subjective and objective assessment tools for the first time. We have also explored its potential mechanis

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Maher, Ann. "Identification of the prostanoid receptor mediating PGE2-induced cough." Thesis, Imperial College London, 2009. http://hdl.handle.net/10044/1/5490.

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Prostaglandin E2 (PGE2) may provide a novel therapy for the treatment of inflammatory airway diseases as it has been shown to confer both bronchodilator and anti-inflammatory activity in asthmatic subjects. However, PGE2 can cause irritancy of the upper airway resulting in a reflex cough. The aim of this thesis was to identify which of the 9 prostanoid receptors (EP1, EP2, EP3, EP4, DP, FP, IP, TP and CRTh2) mediate the PGE2-induced cough. The cough reflex is under the control of sensory afferent nerve fibres that innervate the lungs via the vagus nerve. Using an in vitro model of vagal sensor

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34

Nasra, Julie. "Modulation of Sensory Nerve Function and the Cough Reflex." Thesis, Imperial College London, 2008. http://hdl.handle.net/10044/1/4252.

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Cough is an important protective reflex. Sensory nerve activity mediating cough may be enhanced during disease. Current antitussives possess little clinical efficacy, therefore research is needed to investigate the modulation of airway sensory nerves in order to understand the mechanisms driving chronic cough. A conscious guinea-pig cough model using different tussive stimuli, known to elicit cough in man, was established. Corresponding in vitro effects of these tussive agents on sensory nerve activation were characterised. These agents were also characterised into sub-types as they produced d

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35

Srikannathasan, Velupillai. "Biochemical and structural analysis of Bordetella pertussis lipopolysaccharide A biosynthetic pathway enzymes." Thesis, University of East Anglia, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.273576.

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Al-Fellah, Giamal Nouri. "Inactivation of Bordetella pertussis by rat lung lavage fluids (LLF)." Thesis, University of Glasgow, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.263427.

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Brotherston, Christopher. "Interaction of Bordetella pertussis adenylate cyclase toxin with target cells." Thesis, University of Glasgow, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.263429.

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MacDonald-Fyall, Julia. "The protective and immunomodulatory properties of Bordetella pertussis adenylate cyclase toxin." Thesis, University of Glasgow, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.248267.

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Garrod, Tracey. "Partial purification and characterisation of Bordetella bronchiseptica dermonecrotic toxin." Thesis, University of Reading, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.239514.

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Funnell, Simon Gordon Paul. "Mechanisms of colonisation of mammalian tissues by Bordetella pertussis." Thesis, Open University, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.239726.

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41

Choudry, Nozhat Bano. "Investigation of the sensitivity of the cough reflex in humans." Thesis, Imperial College London, 1991. http://hdl.handle.net/10044/1/46713.

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Decalmer, Samantha Clare. "Phenotyping patients with chronic cough presenting to a specialist clinic." Thesis, University of Manchester, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.494302.

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Introduction: Chronic cough is a common complaint, accounting for one third of all referrals to chest physicians. National and international guidelines exist for treatment and investigation, despite this, in upto 42% of patients, no cause for cough is found. Whether this represents undiagnosed pathology, inadequate treatment or 'idiopathic cough' is unclear. Gastro-oesophageal reflux is reported as a common cause of chronic cough but the exact mechanism by which this occurs is unclear. Both direct cough receptor stimulation (microaspiration and LPR), and indirect stimulation (an oesophago-trac

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Turner, Richard. "A description of cough in tuberculosis and other respiratory conditions." Thesis, Queen Mary, University of London, 2016. http://qmro.qmul.ac.uk/xmlui/handle/123456789/23613.

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Cough is common but has been under-researched. In tuberculosis cough is probably of particular relevance in transmitting infection. This thesis explores several interlinking areas. Regarding how best to measure cough, coughs are shown to be recognizable to the human ear, but automated cough monitors can disagree with auditory cough counting. A novel approach to testing cough reflex sensitivity is described, E62.5. There was no evidence to support the hypothesis that cough has unique characteristics in tuberculosis, in terms of symptoms, frequency and clustering. A significant reduction of coug

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44

Hilton, Emma. "Towards an understanding of the neurophysiology of cough in humans." Thesis, University of Manchester, 2012. https://www.research.manchester.ac.uk/portal/en/theses/towards-an-understanding-of-the-neurophysiology-of-cough-in-humans(f314ffdd-9ea0-4732-af27-afd7f34f9ffa).html.

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Rationale: Chronic cough (cough >8 weeks) is common, leads to an impaired quality of life, and is difficult to treat. Despite intensive investigation, ~40% of patients referred to a specialist cough clinic will remain resistant to treatment targeted at peripheral triggers such as reflux disease, rhino-sinusitis or airways inflammation. An improved understanding of underlying mechanisms in such patients would facilitate drug development. I propose that there are several important similarities between pain and cough that can be exploited better to understand underlying mechanisms. In chronic pai

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45

Advani, Abdolreza. "Epidemiological characterisation of Bordatella pertussis in Sweden, 1970-2004 /." Stockholm, 2007. http://diss.kib.ki.se/2007/978-91-7357-052-7/.

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46

Zawawi, Nor Shahrina. "Measuring voluntary cough and its relationship to the perception of voice." Thesis, University of Canterbury. Department of Communication Disorders, 2010. http://hdl.handle.net/10092/3923.

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Cough is a motor act of the laryngeal and respiratory systems. Features of coughing have been considered in the examination of respiratory, swallowing and voice disorders. Although some voice disorders have been linked to excessive coughing, the precise relationship between cough and voice remains unknown. The present study examined the acoustic features of cough across sex and age; and its relationship to the perception of voice production. A total of 30 cough samples and 30 voice samples were collected from 15 healthy females and 15 healthy males; ranging from young age (17-25 years old), mi

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47

Gorringe, A. R. "The effects of growth conditions on the expression of virulence determinants of Bordetella pertussis." Thesis, University of Southampton, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.235294.

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48

Berry, P. R. "Production of monoclonal antibodies to Bordetella pertussis as a means of identifying protective antigens." Thesis, University of Reading, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.376819.

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49

Li, Jing-Li. "A molecular study of virulence factors of Bordetella species." Thesis, Open University, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.303193.

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A 1kb HinfI DNA fragment, containing a repeat DNA sequence element was isolated from a Bordetella pertussis BP348 cosmid gene bank. This repeat DNA sequence has subsequently been named IS148. The insertion sequence was demonstrated by have a high copy number only in B.pertissus and to be absent in Bordetella parapertussis and Bordetella bronchiseptica. Using a restriction fragment of IS148 labelled with radioactivity as a probe in DNA or whole cell dot blots between 10-100 cells could be detected or from 100pb-1ng DNA. Furthermore, a pair of oligonucleotide primers was synthesised correspondin

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Черняк, О. М., Г. С. Зайцева, О. Г. Васильєва та ін. "Особливості перебігу кашлюку в м. Суми та Сумській області". Thesis, Видавництво СумДУ, 2012. http://essuir.sumdu.edu.ua/handle/123456789/27426.

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