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Artykuły w czasopismach na temat „Cytoprotective agent”

Autor: Grafiati

Data publikacji: 2 czerwca 2025

Data aktualizacji: 31 lipca 2025

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1

Marcantonini, Giada, Desirée Bartolini, Linda Zatini, et al. "Natural Cryoprotective and Cytoprotective Agents in Cryopreservation: A Focus on Melatonin." Molecules 27, no. 10 (2022): 3254. http://dx.doi.org/10.3390/molecules27103254.

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Cryoprotective and cytoprotective agents (Cytoprotective Agents) are fundamental components of the cryopreservation process. This review presents the essentials of the cryopreservation process by examining its drawbacks and the role of cytoprotective agents in protecting cell physiology. Natural cryoprotective and cytoprotective agents, such as antifreeze proteins, sugars and natural deep eutectic systems, have been compared with synthetic ones, addressing their mechanisms of action and efficacy of protection. The final part of this article focuses melatonin, a hormonal substance with antioxid

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Bock, Fabian, Khurrum Shahzad, Nathalie Vergnolle, and Berend Isermann. "Activated protein C based therapeutic strategies in chronic diseases." Thrombosis and Haemostasis 111, no. 04 (2014): 610–17. http://dx.doi.org/10.1160/th13-11-0967.

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SummaryActivated protein C (aPC) is a natural anticoagulant and a potent antiinflammatory and cytoprotective agent. At the expense of increased bleeding risk aPC has been used – with some success – in sepsis. The design of cytoprotective-selective aPC variants circumvents this limitation of increased bleeding, reviving the interest in aPC as a therapeutic agent. Emerging studies suggest that aPC’s beneficial effects are not restricted to acute illness, but likewise relevant in chronic diseases, such as diabetic nephropathy, neurodegeneration or wound healing. Epigenetic regulation of gene expr

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Johns, Paul, Suzette L. Pereira, Amanda E. Leonard, et al. "Cytoprotective Agent in Lactobacillus bulgaricus Extracts." Current Microbiology 54, no. 2 (2007): 131–35. http://dx.doi.org/10.1007/s00284-006-0256-6.

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Sikiric, Predrag, Rudolf Rucman, Branko Turkovic, et al. "Novel Cytoprotective Mediator, Stable Gastric Pentadecapeptide BPC 157. Vascular Recruitment and Gastrointestinal Tract Healing." Current Pharmaceutical Design 24, no. 18 (2018): 1990–2001. http://dx.doi.org/10.2174/1381612824666180608101119.

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Years ago, we revealed a novel cytoprotective mediator, stable gastric pentadecapeptide BPC 157, particular anti-ulcer peptide that heals different organs lesions when given as a therapy, native in human gastric juice while maintaining GI-tract mucosal integrity, already tested in trials (ulcerative colitis and now multiple sclerosis). The stomach cytoprotection is the most fundamental concept, stomach cell protection and endothelium protection are largely elaborated, but so far cell, protection and endothelium protection outside of the stomach were not implemented in the therapy. However, hav

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Muddu Krishna, C., J. N. Kolla, Hari Babu Bollikolla, T. Sravan Kumar Reddy, and S. Asha. "Ethyl Gallate: Promising Cytoprotective against HIV-1-Induced Cytopathy and Antiretroviral-Induced Cytotoxicity." Advances in Virology 2023 (July 12, 2023): 1–8. http://dx.doi.org/10.1155/2023/6727762.

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Introduction. HIV-1 infection in cell culture is typically characterized by certain cytopathic effects such as vacuolization of cells and development of syncytia, which further lead to cell death. In addition, the majority of drugs during HIV treatment exhibit serious adverse effects in patients, apart from their beneficial role. During the screening of cytoprotective agents to protect the cells from HIV-1-associated cell death and also drug-associated toxicity, antioxidants from a natural source are assumed to be a choice. A well-known antioxidant, ethyl gallate (EG), was selected for cytopro

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Gundersen, R. Y., P. Vaagenes, T. Breivik, F. Fonnum, and P. K. Opstad. "Glycine - an important neurotransmitter and cytoprotective agent." Acta Anaesthesiologica Scandinavica 49, no. 8 (2005): 1108–16. http://dx.doi.org/10.1111/j.1399-6576.2005.00786.x.

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Hackler, László, Márió Gyuris, Orsolya Huzián, et al. "Enantioselective Synthesis of 8-Hydroxyquinoline Derivative, Q134 as a Hypoxic Adaptation Inducing Agent." Molecules 24, no. 23 (2019): 4269. http://dx.doi.org/10.3390/molecules24234269.

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Hypoxia is a common feature of neurodegenerative diseases, including Alzheimer’s disease that may be responsible for disease pathogenesis and progression. Therefore, the hypoxia-inducible factor (HIF)1 system, responsible for hypoxic adaptation, is a potential therapeutic target to combat these diseases by activators of cytoprotective protein induction. We have selected a candidate molecule from our cytoprotective hydroxyquinoline library and developed a novel enantioselective synthesis for the production of its enantiomers. The use of quinidine or quinine as a catalyst enabled the preparation

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Plotnikov, Evgenii, Innokenty Losenkov, Elena Epimakhova, and Nikolay Bohan. "Protective Effects of Pyruvic Acid Salt Against Lithium Toxicity and Oxidative Damage in Human Blood Mononuclear Cells." Advanced Pharmaceutical Bulletin 9, no. 2 (2019): 302–6. http://dx.doi.org/10.15171/apb.2019.035.

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Purpose: Aim of present work was to study cytoprotective properties of lithium pyruvate, as a prospective pharmacological agent. Pyruvate has a lot of potential benefits due to positive influence on cell metabolism. Lithium is "gold-standard" mood-stabilizer. Combination of both may lead advantages. Methods: Lithium pyruvate was tested as cytoprotector on human blood mononuclears under induced oxidative stress. Cells were obtained from healthy donors and patients with alcoholism. The detection of cell viability, apoptosis and determination of oxidative stress level were conducted by flow cytom

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Kuprash, Liana, Tetyana Panteleymonova, Nina Sykalo, Irina Labunets, and Vladislav Bezrukov. "Nootropic properties of a new combined cytoprotective agent." Issue 3 2022, no. 3 2022 (August 11, 2022): 92–100. http://dx.doi.org/10.47855/jal9020-2022-3-4.

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Medicinal products of nootropic action, which have a positive effect on neurometabolism and normalize memory and intellectual functions, are an important component of complex pharmacotherapy for various neurological and cerebrovascular diseases. The aim of the work was an experimental study of the nootropic activity of the new combined drug Melarginin, which includes 3-(2,2,2-trimethylhydrazinium) propionate (meldonium), L-arginine, and inosine in a fixed ratio. In experiments on female Balb/c mice, it was established that Melarginin in doses of 250 and 500 mg/kg (per os for 14 days) statistic

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10

Martinel Lamas, D. J., M. B. Nicoud, H. A. Sterle, G. A. Cremaschi, and V. A. Medina. "Histamine: a potential cytoprotective agent to improve cancer therapy?" Cell Death & Disease 6, no. 12 (2015): e2029-e2029. http://dx.doi.org/10.1038/cddis.2015.378.

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Jiang, Z. G., X. C. M. Lu, V. Nelson, et al. "A multifunctional cytoprotective agent that reduces neurodegeneration after ischemia." Proceedings of the National Academy of Sciences 103, no. 5 (2006): 1581–86. http://dx.doi.org/10.1073/pnas.0510573103.

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Zhong, Zhi, Micheal D. Wheeler, Xiangli Li, et al. "L-Glycine: a novel antiinflammatory, immunomodulatory, and cytoprotective agent." Current Opinion in Clinical Nutrition and Metabolic Care 6, no. 2 (2003): 229–40. http://dx.doi.org/10.1097/00075197-200303000-00013.

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Amico-Roxas, M., A. Caruso, and V. M. C. Cutuli. "Gastric cytoprotective activity of ALAU, A novel antiulcer agent." Pharmacological Research 25 (May 1992): 271. http://dx.doi.org/10.1016/1043-6618(92)90399-v.

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Hassane, Duane C., Siddhartha Sen, Mohammad Minhajuddin, et al. "Chemical genomic screening reveals synergism between parthenolide and inhibitors of the PI-3 kinase and mTOR pathways." Blood 116, no. 26 (2010): 5983–90. http://dx.doi.org/10.1182/blood-2010-04-278044.

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Abstract We have previously shown that the plant-derived compound parthenolide (PTL) can impair the survival and leukemogenic activity of primary human acute myeloid leukemia (AML) stem cells. However, despite the activity of this agent, PTL also induces cellular protective responses that likely function to reduce its overall cytotoxicity. Thus, we sought to identify pharmacologic agents that enhance the antileukemic potential of PTL. Toward this goal, we used the gene expression signature of PTL to identify compounds that inhibit cytoprotective responses by performing chemical genomic screeni

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15

Romashchenko, O. V. "Personalized trimetazidine prescription as a cytoprotective agent in patients with coronary artery disease." Russian Journal of Cardiology 26, no. 6 (2021): 4532. http://dx.doi.org/10.15829/1560-4071-2021-4532.

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Aim. To develop a personalized approach to the trimetazidine use in patients with coronary artery disease (CAD) based on the criteria for predicting the cytoprotective activity tested in vitro.Material and methods. We examined 30 patients with class I-III stable effort angina with concomitant hypertension and heart failure. The patients underwent echocardiography, complete blood count, biochemical tests with determination of the lipid profile, creatine phosphokinase (CPK), CPK-MB, renal and hepatic parameters. To determine the cytoprotective activity of trimetazidine, white blood cells (WBCs)

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Staresinic, Mario, Mladen Japjec, Hrvoje Vranes, et al. "Stable Gastric Pentadecapeptide BPC 157 and Striated, Smooth, and Heart Muscle." Biomedicines 10, no. 12 (2022): 3221. http://dx.doi.org/10.3390/biomedicines10123221.

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First, we review the definitively severed myotendinous junction and recovery by the cytoprotective stable gastric pentadecapeptide BPC 157 therapy, its healing that might combine both transected and detached tendon and transected muscle, ligament and bone injuries, applied alone, as native peptide therapy, effective in rat injury, given intraperitoneally or in drinking water or topically, at the site of injury. As a follow up, we reviewed that with the BPC 157 therapy, its cytoprotective ability to organize simultaneous healing of different tissues of and full recovery of the myotendinous junc

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Kenneth Maiese, Bentham Science Publisher, Bentham Science Publisher Shi-Hua Lin, and Bentham Science Publisher Zhao Zhong Chong. "Elucidating Neuronal and Vascular Injury Through the Cytoprotective Agent Nicotinamide." Current Medicinal Chemistry-Immunology, Endocrine & Metabolic Agents 1, no. 3 (2001): 257–67. http://dx.doi.org/10.2174/1568013013359069.

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LEVY, J. H. "The ideal agent for perioperative hypertension and potential cytoprotective effects." Acta Anaesthesiologica Scandinavica 37 (September 1993): 20–25. http://dx.doi.org/10.1111/j.1399-6576.1993.tb03819.x.

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Lefer, Allan M. "Peroxynitrite as a cytoprotective agent in myocardial ischemia/reperfusion injury." Pathophysiology 5 (June 1998): 38. http://dx.doi.org/10.1016/s0928-4680(98)80423-9.

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Cásedas, Guillermo, Francisco Les, Carmen Choya-Foces, Martín Hugo, and Víctor López. "The Metabolite Urolithin-A Ameliorates Oxidative Stress in Neuro-2a Cells, Becoming a Potential Neuroprotective Agent." Antioxidants 9, no. 2 (2020): 177. http://dx.doi.org/10.3390/antiox9020177.

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Urolithin A is a metabolite generated from ellagic acid and ellagitannins by the intestinal microbiota after consumption of fruits such as pomegranates or strawberries. The objective of this study was to determine the cytoprotective capacity of this polyphenol in Neuro-2a cells subjected to oxidative stress, as well as its direct radical scavenging activity and properties as an inhibitor of oxidases. Cells treated with this compound and H2O2 showed a greater response to oxidative stress than cells only treated with H2O2, as mitochondrial activity (MTT assay), redox state (ROS formation, lipid

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Lee, Phil Jun, Hye-Jin Park, Hee Min Yoo, and Namki Cho. "Betulin Protects HT-22 Hippocampal Cells against ER Stress through Induction of Heme Oxygenase-1 and Inhibition of ROS Production." Natural Product Communications 14, no. 12 (2019): 1934578X1989668. http://dx.doi.org/10.1177/1934578x19896684.

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A key pathologic event in neurodegenerative diseases, such as Alzheimer’s disease and Parkinson’s disease, is endoplasmic reticulum (ER) stress-induced neuronal cell death. ER stress-induced generation of reactive oxygen species (ROS) has been implicated in neurological disease processes. Betulin is one of the major triterpenoids found in Betula platyphylla that possesses several biological properties, including cytoprotective and antioxidative effects. Therefore, we investigated whether betulin could prevent ER stress-induced neurotoxicity in HT-22 hippocampal neuronal cells. We observed that

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Eftekhari, Aziz, Reza Heidari, Elham Ahmadian, and Mohammad Ali Eghbal. "Cytoprotective Properties of Carnosine against Isoniazid-Induced Toxicity in Primary Cultured Rat Hepatocytes." Pharmaceutical Sciences 24, no. 4 (2018): 257–63. http://dx.doi.org/10.15171/ps.2018.38.

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Background: Drug-induced liver injury is a critical clinical complication. Hence, finding new and safe protective agents with potential clinical application is of value. Isoniazid (INH) is an antituberculosis agent widely used against Mycobacterium tuberculosis infection in human. On the other hand, hepatotoxicity is a clinical complication associated with isoniazid therapy. Oxidative stress and its associated events are major mechanisms identified for INH-induced liver injury. Carnosine is an endogenously found peptide widely investigated for its hepatoprotective effects. On the other hand, r

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Elshazly, Ahmed M., and David A. Gewirtz. "Is Autophagy Inhibition in Combination with Temozolomide a Therapeutically Viable Strategy?" Cells 12, no. 4 (2023): 535. http://dx.doi.org/10.3390/cells12040535.

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Temozolomide is an oral alkylating agent that is used as the first line treatment for glioblastoma multiform, and in recurrent anaplastic astrocytoma, as well as having demonstrable activity in patients with metastatic melanoma. However, as the case with other chemotherapeutic agents, the development of resistance often limits the therapeutic benefit of temozolomide, particularly in the case of glioblastoma. A number of resistance mechanisms have been proposed including the development of cytoprotective autophagy. Cytoprotective autophagy is a survival mechanism that confers upon tumor cells t

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Koga, Tetsufumi, Harumi Kawada, Yukio Utsui, Haruki Domon, Chika Ishii, and Hiroshi Yasuda. "Bactericidal effect of plaunotol, a cytoprotective antiulcer agent, against Helicobacter pylori." Journal of Antimicrobial Chemotherapy 38, no. 3 (1996): 387–97. http://dx.doi.org/10.1093/jac/38.3.387.

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Juan, O., A. Rocher, B. Quintana, R. Ferrando, A. Sánchez-Alcaraz, and V. Alberola. "Influence of the cytoprotective agent amifostine on the pharmacokinetics of paclitaxel." European Journal of Cancer 37 (April 2001): S69. http://dx.doi.org/10.1016/s0959-8049(01)80736-x.

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Playford, Raymond J., Tania Marchbank, Rebecca Chinery, et al. "Human spasmolytic polypeptide is a cytoprotective agent that stimulates cell migration." Gastroenterology 108, no. 1 (1995): 108–16. http://dx.doi.org/10.1016/0016-5085(95)90014-4.

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Cardinali, Daniel P., and Arturo Garay. "Melatonin as a Chronobiotic/Cytoprotective Agent in REM Sleep Behavior Disorder." Brain Sciences 13, no. 5 (2023): 797. http://dx.doi.org/10.3390/brainsci13050797.

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Dream-enactment behavior that emerges during episodes of rapid eye movement (REM) sleep without muscle atonia is a parasomnia known as REM sleep behavior disorder (RBD). RBD constitutes a prodromal marker of α-synucleinopathies and serves as one of the best biomarkers available to predict diseases such as Parkinson disease, multiple system atrophy and dementia with Lewy bodies. Most patients showing RBD will convert to an α-synucleinopathy about 10 years after diagnosis. The diagnostic advantage of RBD relies on the prolonged prodromal time, its predictive power and the absence of disease-rela

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Lee, Jong Yoon, and Jin Seok Jang. "The effect of PPIs Alone, PPIs plus cytoprotective agent, and H2RA plus cytoprotective agent on ulcer healing after endoscopic submucosal dissection: A prospective randomized controlled trial." Arab Journal of Gastroenterology 22, no. 2 (2021): 115–20. http://dx.doi.org/10.1016/j.ajg.2020.09.007.

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Moroz, V. V., A. M. Chernysh, and Elena K. Kozlova. "Coronavirus SARS-CoV-2: Hypotheses of Impact on the Circulatory System, Prospects for the Use of Perfluorocarbon Emulsion, and Feasibility of Biophysical Research Methods." General Reanimatology 16, no. 3 (2020): 4–13. http://dx.doi.org/10.15360/1813-9779-2020-3-0-1.

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This paper highlights published hypotheses on the possibility of coronavirus SARS-CoV-2 entry into the bloodstream, its interaction with vascular endothelium, red blood cells, hemoglobin and its fragments. As a result of such interaction, iron ions may be released into the bloodstream and, subsequently, a cytokine storm may occur. In this context, it is important to find a cytoprotective agent capable of blocking such processes. The perfluorocarbon emulsion could be a candidate for this role.The aim of the paper is to show the feasibility of biophysical methods to study the molecular mechanism

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Bhardwaj Shukla, Ritwiz, N. Ganesh, and M. L. Kori. "Cytoprotection Alternatives for Cancer Treatment: In-vitro Evaluation of Alpinia Zerumbet as a Radioprotective Agent." Journal of Drug Delivery and Therapeutics 9, no. 4-s (2019): 171–76. http://dx.doi.org/10.22270/jddt.v9i4-s.3268.

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Cancer radiotherapy and modern synthetic medicine are critical for the treatment of cancer patients, but on the other hand they may have tremendous harmful side effect from the point of view of a weakened immune system. The focus of current research efforts in the industry and academia is not only to find affordable treatment methodologies but also to discover sources that mitigates or prevents the negative impact of these treatments on the patient’s immune system. This review will provide details of optimal methodology involving Invitro application of techniques such as phytochemical analysis

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Golda, Anna, Paulina Kosikowska-Adamus, Aleksandra Kret, et al. "The Bactericidal Activity of Temporin Analogues Against Methicillin Resistant Staphylococcus aureus." International Journal of Molecular Sciences 20, no. 19 (2019): 4761. http://dx.doi.org/10.3390/ijms20194761.

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Staphylococcus aureus is a major infectious agent responsible for a plethora of superficial skin infections and systemic diseases, including endocarditis and septic arthritis. Recent epidemiological data revealed the emergence of resistance to commonly used antibiotics, including increased numbers of both hospital- and community-acquired methicillin-resistant S. aureus (MRSA). Due to their potent antimicrobial functions, low potential to develop resistance, and immunogenicity, antimicrobial peptides (AMPs) are a promising alternative treatment for multidrug-resistant strains. Here, we examined

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Wills, Brandon K., Steven E. Aks, Gerry E. Maloney, James W. Rhee, Rhonda Brand, and Marin Sekosan. "The effect of amifostine, a cytoprotective agent, on paraquat toxicity in mice." Journal of Medical Toxicology 3, no. 1 (2007): 1–6. http://dx.doi.org/10.1007/bf03161031.

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Zager, R. A., K. M. Burkhart, D. S. Conrad, D. J. Gmur, and M. Iwata. "Phospholipase A2-induced cytoprotection of proximal tubules: potential determinants and specificity for ATP depletion-mediated injury." Journal of the American Society of Nephrology 7, no. 1 (1996): 64–72. http://dx.doi.org/10.1681/asn.v7164.

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Addition of phospholipase A2 (PLA2) to isolated proximal tubular segments (PTS) has previously been shown to decrease hypoxic cell death without altering ATP concentrations. The study presented here was undertaken to identify determinant(s) of this protection, and to define the spectrum of injuries against which it can operate. PTS were extracted from mouse kidneys and subjected to diverse forms of injury (hypoxia/reoxygenation, antimycin A, Ca2+ ionophore, amphotericin B, FeSO4, and myohemoglobin). In subtoxic doses, addition of PLA2 significantly reduced hypoxic- and antimycin A-induced inju

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Srdjenovic, Branislava, Marija Slavic, Karmen Stankov, et al. "Size distribution of fullerenol nanoparticles in cell culture medium and their influence on antioxidative enzymes in Chinese hamster ovary cells." Chemical Industry 69, no. 4 (2015): 425–31. http://dx.doi.org/10.2298/hemind131218054s.

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Fullerenol (C60(OH)24) nanoparticles (FNP) have a significant role in biomedical research due to their numerous biological activities, some of which are cytoprotective and antioxidative properties. The aim of this study was to measure distribution of fullerenol nanoparticles and zeta potential in cell medium RPMI 1640 with 10% fetal bovine serum (FBS) and to investigate the influence of FNP on Chinese hamster ovary cells (CHO-K1) survival, as well as to determine the activity of three antioxidative enzymes: superoxide-dismutase, glutathione-reductase and glutathione-S-transferase in mitomycin

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Anbesse, Reta Wakoya. "Impact of Embalica Officinalis: A miracle multipurpose plant." Journal of Medical Research and Innovation 4, no. 1 (2019): e000199. http://dx.doi.org/10.32892/jmri.199.

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Plants are a major source of nutrition and health care. Embalicalofficinalis is one of the most widely used in traditional Indian medicine in different form and believed to alleviate against several disease. This article summarizes multipurpose and medicinal value of Embalicaofficinalis (EO). I reviewed the application of EO in antioxidant, antidiabetic, anticancer, antiulcer, cardioprotective activity, cytoprotective, antitussive, immunomodualation, chelating agent, and respiratory problems.

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Song, Hwa Young, Sejong Jin, Sekwang Lee, Angela Melinda Anthony Jalin, Kyung-Hye Roh, and Won-Ki Kim. "The Therapeutic Effects of SP-8356, a Verbenone Derivative, with Multimodal Cytoprotective Mechanisms in an Ischemic Stroke Rat Model." International Journal of Molecular Sciences 25, no. 23 (2024): 12769. http://dx.doi.org/10.3390/ijms252312769.

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An ischemic cerebral stroke results from the interruption of blood flow to the brain, triggering rapid and complex cascades of excitotoxicity, oxidative stress, and inflammation. Current reperfusion therapies, including intravenous thrombolysis and mechanical thrombectomy, cause further brain injury due to reperfusion-induced cytotoxicity. To date, novel cytoprotective therapies that could address these challenges have yet to be developed, likely due to the limitations of targeting a single pathologic mechanism. To address these unmet clinical needs, we investigated a synthetic verbenone deriv

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Luckring, Emilee J., Patrick D. Parker, Homayoun Hani, et al. "In Vitro Evaluation of a Novel Synthetic Bilirubin Analog as an Antioxidant and Cytoprotective Agent for Pancreatic Islet Transplantation." Cell Transplantation 29 (January 1, 2020): 096368972090641. http://dx.doi.org/10.1177/0963689720906417.

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Bilirubin is a natural cytoprotective agent and physiologic doses have proven to be beneficial in various models of organ and cellular transplantation. Recently, we showed that bilirubin has protective effects in models of pancreatic islet transplantation, preventing cell death associated with islet stress and suppressing the release of damage-associated molecular patterns. Despite these promising therapeutic attributes, the natural bilirubin used in these research studies is animal-derived (porcine), making it unsuitable for clinical application. In the current study, we synthesized two bilir

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Kondo, Isamu, and Masashl Yamaguchi. "Morphological changes of Helicobacter pylori caused in vitro by cytoprotective anti-ulcer drug, Sofalcone." Proceedings, annual meeting, Electron Microscopy Society of America 48, no. 3 (1990): 620–21. http://dx.doi.org/10.1017/s0424820100160650.

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Since Helicobacter pylori has recently been regarded as a possible causative agent of a chronic gastritis and a peptic ulcer disease, the susceptibilities of this organism to anti-ulcer agents or antibiotics have attracted much interest of not only clinical docters but also medicobiologists.We have reported that Sofalcone, a cytoprotective anti-ulcer drug, has anti-bacterial and bactericidal activity as well as TDS (tripotassium dicitrats bithmuthate) and Clarithromycin (a derivative of erythromycin), but the other anti-ulcer drugs Including anti-acid or H2 receptor antagonists such as cimetid

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CARDINALI, D. P. "Clinical Perspectives for the Use of Melatonin as a Chronobiotic and Cytoprotective Agent." Annals of the New York Academy of Sciences 1057, no. 1 (2005): 327–36. http://dx.doi.org/10.1196/annals.1356.025.

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MURAKAMI, Motonobu, Jung Keun YOO, Sanae TERAMURA, et al. "Cytoprotective Effect of Plasmin Inhibitor on Necrotizing Agent-Induced Gastric Lesions in Rats." Japanese Journal of Pharmacology 50, no. 1 (1989): 72–74. http://dx.doi.org/10.1016/s0021-5198(19)42488-8.

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Son, Sohee, Eun Ji Park, Yejin Kim, Kang Choon Lee та Dong Hee Na. "Chemical chaperone-conjugated exendin-4 as a cytoprotective agent for pancreatic β-cells". International Journal of Biochemistry & Cell Biology 105 (грудень 2018): 13–19. http://dx.doi.org/10.1016/j.biocel.2018.09.018.

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Ostenfeld, Marie Stampe, Maria Høyer-Hansen, Lone Bastholm, et al. "Anti-cancer agent siramesine is a lysosomotropic detergent that induces cytoprotective autophagosome accumulation." Autophagy 4, no. 4 (2008): 487–99. http://dx.doi.org/10.4161/auto.5774.

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MURAKAMI, Motonobu, Jung Keun YOO, Sanae TERAMURA, et al. "Cytoprotective effect of plasmin inhibitor on necrotizing agent-induced gastric lesions in rats." Japanese Journal of Pharmacology 50, no. 1 (1989): 72–74. http://dx.doi.org/10.1254/jjp.50.72.

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Suganth, Dr V. "Epigallo Catechin Gallate (EGCG) and Sorafenib: A Better Cytoprotective Agent in Diethyl Nitrosamine (DEN) Induced Liver Cancer – Anin Vivo Study." Chettinad Health City Medical Journal 12, no. 02 (2023): 63–70. http://dx.doi.org/10.24321/2278.2044.202329.

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Vaha-Koskela, Markus, Muhammad Ammad-ud-din, Kirsi Siivola, et al. "Expanding the Utility of Midostaurin in Acute Myeloid Leukemia - Predictive Mutational Signatures in Patient Samples without FLT3 mutations and Clinically Applicable Synergistic Drug Combinations." Blood 132, Supplement 1 (2018): 2743. http://dx.doi.org/10.1182/blood-2018-99-116391.

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Abstract Background Following the positive outcome of the RATIFY phase 3 clinical trial, the multi-kinase inhibitor midostaurin was approved for the treatment of adult patients with newly diagnosed FLT3-mutated acute myeloid leukemia (AML). However, we and others have observed that single agent midostaurin yields responses also in a substantial portion of patients not carrying FLT3 mutations. The molecular basis and the kinase targets mediating these responses are poorly understood and no biomarkers predictive of response in FLT3 wildtype (wt) AML patients exist. To identify markers distinguis

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Pan, Jianru, Lingling Li, Lili Liang, et al. "Cytoprotective Effects of Cell-Permeable Bifunctional Antioxidant Enzyme, GST-TAT-SOD, against Cisplatin-Induced Cell Damage." Oxidative Medicine and Cellular Longevity 2017 (2017): 1–7. http://dx.doi.org/10.1155/2017/9530791.

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GST-TAT-SOD, a cell-permeable bifunctional antioxidant enzyme, is a potential selective radioprotector. This study aimed to investigate the cytoprotective activity of GST-TAT-SOD against cisplatin-induced damage. The current study showed that cisplatin induced the formation of reactive oxygen species in normal L-02 cells. GST-TAT-SOD (2000 U/mL) executed its antioxidant role by directly scavenging excess intracellular free radicals and augmenting cellular antioxidant defense such as reducing MDA level, enhancing the SOD activity, GST activity, and T-AOC. Thus, it suppressed the growth inhibiti

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Lee, Wonseok, Yewon Mun, Kang-Yo Lee, et al. "Mefenamic Acid-Upregulated Nrf2/SQSTM1 Protects Hepatocytes against Oxidative Stress-Induced Cell Damage." Toxics 11, no. 9 (2023): 735. http://dx.doi.org/10.3390/toxics11090735.

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Mefenamic acid (MFA) is a commonly prescribed non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory and analgesic properties. MFA is known to have potent antioxidant properties and a neuroprotective effect against oxidative stress. However, its impact on the liver is unclear. This study aimed to elucidate the antioxidative effects of MFA and their underlying mechanisms. We observed that MFA treatment upregulated the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway. Treatment with various anthranilic acid derivative-class NSAIDs, including MFA, increased the expression o

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Rondags, Angelique, Wing Yan Yuen, Marcel F. Jonkman, and Barbara Horváth. "Fullerene C60with cytoprotective and cytotoxic potential: prospects as a novel treatment agent in Dermatology?" Experimental Dermatology 26, no. 3 (2017): 220–24. http://dx.doi.org/10.1111/exd.13172.

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Chamulitrat, W., J. Burhenne, T. Rehlen, A. Pathil-Warth, and W. Stremmel. "138 A NOVEL BILE SALT-PHOSPHOLIPID CONJUGATE URSODEOXYCHOLYL-LYSOPHOSPHATIDYLETHANOLAMIDE AS A HEPATIC CYTOPROTECTIVE AGENT." Journal of Hepatology 48 (January 2008): S59. http://dx.doi.org/10.1016/s0168-8278(08)60140-3.

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Genvresse, Isabelle, Catalina Lange, Julie Schanz, et al. "Tolerability of the cytoprotective agent amifostine in elderly patients receiving chemotherapy: a comparative study." Anti-Cancer Drugs 12, no. 4 (2001): 345–49. http://dx.doi.org/10.1097/00001813-200104000-00007.

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