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Rozprawy doktorskie na temat „Cytoskeleton”

Autor: Grafiati

Data publikacji: 4 czerwca 2021

Data aktualizacji: 25 lipca 2025

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1

Morgan, Rachel E. "Is the Cytoskeleton Necessary for Viral Replication?" Digital Archive @ GSU, 2012. http://digitalarchive.gsu.edu/biology_theses/38.

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The cytoskeleton plays an important role in trafficking proteins and other macromolecular moieties throughout the cell. Viruses have been thought to depend heavily on the cytoskeleton for their replication cycles. However, studies, including one in our lab, found that some viruses are not inhibited by anti-microtubule drugs. This study was undertaken to evaluate the replication of viruses from several families in the presence of cytoskeleton-inhibiting drugs and to examine the intracellular localization of the proteins of one of these viruses, Sindbis virus, to test the hypothesis that alterna

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2

McDermott, Joshua D. "The ovine lens cytoskeleton." Lincoln University, 2007. http://hdl.handle.net/10182/700.

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The lens of the eye is a vital tissue in the visual system, responsible for the collection and focusing of light on to the retina. Comprised of epithelial cells at differing stages of differentiation, the transparency of the lens is dependent on the highly ordered crystalline structure of lens proteins. The lens consists of several proteins including crystallins (α, β, γ) that make up 90% of the soluble protein, and the lens cytoskeletal proteins. Cytoskeletal proteins contribute only a fraction of the total lens protein, but are thought to play an important role in the establishment and maint

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3

Snyder, Heidi Ghent. "Fiber type-specific desmin content in human single muscle fibers /." Diss., CLICK HERE for online access, 2006. http://contentdm.lib.byu.edu/ETD/image/etd1253.pdf.

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4

Fawell, E. H. "Studies on the microvillus cytoskeleton." Thesis, University of Leeds, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.355700.

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5

Schneider, André. "The cytoskeleton of Trypanosoma brucei /." [S.l.] : [s.n.], 1988. http://www.ub.unibe.ch/content/bibliotheken_sammlungen/sondersammlungen/dissen_bestellformular/index_ger.html.

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6

McCarthy, David James. "Analysis of the novel Lyn-associated cytoskeletal modular protein, LACM." University of Western Australia. School of Medicine and Pharmacology, 2009. http://theses.library.uwa.edu.au/adt-WU2009.0180.

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A yeast-two hybrid screen with Lyn identified a novel 130 kDa multidomain protein with a 36% identity to Actin Filament Associated Protein (AFAP) 110 and similar domains, including PH domains, potential sites of tyrosine and serine/threonine phosphorylation, a leucine-zipper domain, a potential actin binding site and multimerization site. AFAP110 has been shown to have a role in modulating actin filament integrity and induce lamellipodia formation, and is known to interact with Src family kinases. The aim of this thesis was to characterize this novel protein named Lyn-Associated Cytoskeletal M

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7

Tharmann, Rainer. "Mechanical properties of complex cytoskeleton networks." [S.l.] : [s.n.], 2006. http://deposit.ddb.de/cgi-bin/dokserv?idn=97998002X.

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8

Brown, Jennifer. "Investigating the actin cytoskeleton in cancer." Thesis, University of Glasgow, 2016. http://theses.gla.ac.uk/7266/.

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Dynamic alterations in the actin cytoskeleton, under the regulation of the Rho/ROCK pathway, permit cell motility, cell-to-cell and cell-to-matrix adhesion, and have also been shown to participate in apoptosis and cell proliferation. These facets of cellular behaviour all have the capacity to become dysregulated in cancer; components of the Rho/ROCK pathway are known to play varying roles in these processes, both within primary tumours and within the tumour microenvironment. The LIM kinases are phosphorylated and activated by ROCK, leading to inactivation of cofilin and subsequent stabilisatio

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9

Balanda, Matthew L. "The use of cytoskeletal inhibitors to determine the role of the cytoskeleton in the activation of hypertonicity-induced currents in xenopus oocytes /." View abstract, 1999. http://library.ctstateu.edu/ccsu%5Ftheses/1561.html.

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Thesis (M.A.)--Central Connecticut State University, 1999.<br>Thesis advisor: Kathy Martin. " ... in partial fulfillment of the requirements for the degree of Master of Arts in Biological Sciences." Includes bibliographical references (leaves 42-44).

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10

Huber, Florian. "Emergent structure formation of the actin cytoskeleton." Doctoral thesis, Universitätsbibliothek Leipzig, 2012. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-86666.

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Anders als menschengemachte Maschinen verfügen Zellen über keinen festgeschriebenen Bauplan und die Positionen einzelner Elemente sind häufig nicht genau festgelegt, da die Moleküle diffusiven Zufallsbewegungen unterworfen sind. Darüber hinaus sind einzelne Bauteile auch nicht auf eine einzelne Funktion festgelegt, sondern können parallel in verschiedene Prozesse einbezogen sein. Basierend auf Selbstorganisation und Selbstassemblierung muß die Organisation von Anordnung und Funktion einer lebenden Zelle also bereits in ihren einzelnen Komponenten inhärent enthalten sein. Die intrazelluläre Or

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11

Boey, Seng Kee. "Computer simulation of the human erythrocyte cytoskeleton." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/nq24296.pdf.

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12

Nuydens, Rony Maria. "Dynamics of the neuronal cytoskeleton during apoptosis." Maastricht : Maastricht : Universiteit Maastricht ; University Library, Maastricht University [Host], 1999. http://arno.unimaas.nl/show.cgi?fid=6860.

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13

Förster, Florian. "Targeting the actin cytoskeleton with natural compounds." Diss., Ludwig-Maximilians-Universität München, 2014. http://nbn-resolving.de/urn:nbn:de:bvb:19-168914.

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Targeting the cytoskeleton (CSK) of cancer cells offers a valuable strategy in cancer therapy. Whereas drugs which address microtubule CSK such as vinca alkaloids or taxanes are well established in the clinic, compounds binding to the actin CSK are still far away from their therapeutical application. One reason might be the lacking knowledge on their mode of cytotoxicity and moreover their tumor specific mechanism of action. We used the myxobacterial compound Chondramide as a tool to first elucidate the mechanisms of cytotoxicity by actin targeting in different breast cancer cells, namely MC

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14

Kim, Taeyoon Ph D. Massachusetts Institute of Technology. "Simulation of actin cytoskeleton structure and rheology." Thesis, Massachusetts Institute of Technology, 2007. http://hdl.handle.net/1721.1/39875.

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Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2007.<br>Includes bibliographical references (p. 81-87).<br>Structures consisting of G-actin or other filament-forming monomers show a variety of morphologies with widely different properties in regard to pore size, degree of isotropy, and extent of cross-linking. These characteristics are primarily determined by the concentration and feature of proteins which cross-link filaments, but little is known how the filament-forming monomers and cross-linking proteins are organized in order to produce various netwo

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15

Ju, M. "Role of membrane cytoskeleton in fenestra biogenesis." Thesis, University College London (University of London), 2013. http://discovery.ucl.ac.uk/1383777/.

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Fenestrae are transcellular membrane pores that mediate blood-tissue exchange in highly specialized vascular endothelia such as in choroidal capillaries. Substances that traverse the pore never encounter the contents of the cytoplasm and are transported in a rapid and presumably energy-efficient manner. Fenestrae arise in attenuated regions of the endothelial cell periphery and are highly organized in clusters termed sieve plates. My PhD project was based on the identification of novel components of fenestrae and how these components contribute to mechanisms regulating fenestra formation. Usin

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16

Dobbins, G. Clement. "The role of the cytoskeleton in AChR clustering." Thesis, Birmingham, Ala. : University of Alabama at Birmingham, 2007. https://www.mhsl.uab.edu/dt/2007p/dobbins.pdf.

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17

Esson, Heather Jean. "Morphological evolution and development of the euglenid cytoskeleton." Thesis, University of British Columbia, 2009. http://hdl.handle.net/2429/6814.

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In an effort to better understand character evolution in the cytoskeleton (pellicle) of euglenid protists, I used comparative and descriptive methods to investigate the morphological diversity and development of pellicle surface patterns formed by differences in strip length at the anterior and posterior ends of the cell (strip reduction). By observing dividing Euglena gracilis cells with scanning electron microscopy (SEM) and integrating these data with previous evolutionary and developmental research, I showed that these patterns result from the semiconservative duplication and subsequent in

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18

Attaran, Amir. "CTL cytotoxicity and the cytoskeleton : a microscopical study." Thesis, University of Oxford, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.308607.

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19

Carballido-Lopez, Rut. "Bacterial cytoskeleton : cell shape determination in Bacillus subtilis." Thesis, University of Oxford, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.270007.

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20

Corben, Elizabeth Bower. "An immunological approach to the higher plant cytoskeleton." Thesis, University of East Anglia, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.540595.

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21

Cain, R. J. "Manipulation of the eukaryotic cytoskeleton by invasive Salmonella." Thesis, University of Cambridge, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.597214.

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Mechanical cell fractionation and immunofluorescence microscopy were applied to systematically investigate the subcellular localisation of epitope-tagged effectors in cultured cells after transfection or infection with wildtype <i>Salmonella </i>strains exogenously expressing individual effectors. Although five <i>Salmonella</i> effectors contain no apparent membrane-targeting domains, all six localised to the plasma membrane fraction and were visualised a the cell periphery, from where they induced distinct effects on the actin cytoskeleton. Unexpectedly, no translocated cytoplasmic effector

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22

Advani, Andrew. "The blood cell cytoskeleton in type 2 diabetes." Thesis, University of Newcastle Upon Tyne, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.289211.

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23

Feret, Dorota. "Proteasomal control of the fission yeast microtubule cytoskeleton." Thesis, University of Manchester, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.704739.

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24

Speldewinde, Shaun. "Prions, autophagy, ageing and actin cytoskeleton in yeast." Thesis, University of Manchester, 2017. https://www.research.manchester.ac.uk/portal/en/theses/prions-autophagy-ageing-and-actin-cytoskeleton-in-yeast(03085d7f-283a-40e1-bcf7-d9533ff2e2fc).html.

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Prions are infectious protein entities capable of self-replication. Prions are the causal agents behind the transmissible spongiform encephalopathies causing neurodegeneration and death in affected organisms. Prions have been identified in yeast with the best-characterized prions being [PSI+] and [PIN+], whose respective native proteins are the Sup35 translation termination factor and Rnq1 (function unknown). Autophagy is a cellular housekeeping mechanism mediating the degradation of damaged proteins and superfluous organelles. It is a highly sequential process regulated by autophagy related g

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25

Uppal, Sonal. "Studies of Microtubule Inhibitor Combinations on Cytoskeleton Architecture." Bowling Green State University / OhioLINK, 2006. http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1162842626.

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26

Turner, Jerrold Ross. "Secretory organelles and the cytoskeleton: Organization and interdependence." Case Western Reserve University School of Graduate Studies / OhioLINK, 1990. http://rave.ohiolink.edu/etdc/view?acc_num=case1054668919.

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27

Kumar, Sanjay. "Molecular mechanisms of organization in the neurofilament cytoskeleton." Available to US Hopkins community, 2002. http://wwwlib.umi.com/dissertations/dlnow/3080703.

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28

Ricci, Mario. "The marsupial sperm tail cytoskeleton : a morphological and biochemical study /." Title page, table of contents and abstract only, 2004. http://web4.library.adelaide.edu.au/theses/09PH/09phr4911.pdf.

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29

Turina, Dean. "Propofol changes the cytoskeletal function in neurons : An experimental study in cortical cultures." Doctoral thesis, Linköpings universitet, Anestesiologi med intensivvård, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-77219.

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Every day, general anaesthetics are given to a large number of patients around the world but the cellular mechanisms of how anaesthetics act are still not clear. General anaesthetics cause the intended unconsciousness, amnesia and immobility in patients, but also side effects such as a decrease in mean arterial pressure and arrhythmia, both of which contribute to complications such as heart damage and stroke. With more knowledge of the mechanism of anaesthetic drugs, these complications could be reduced. It has been shown that anaesthetics cause a disruption of the thalamocortical connectivity

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30

Jopson, Martin Frederick. "Plant microtubules, their associated proteins and the cell cycle." Thesis, University of East Anglia, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.318090.

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31

Bellamy, Matthew Laurence. "A study of non-erythroid isoforms of protein 4.1." Thesis, University of Kent, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.298166.

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32

Marks, John. "Cytological and biochemical investigation of actin in the fission yeast Schizosaccharomyces pombe." Thesis, University College London (University of London), 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.337930.

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33

Wong, Chun-ming. "B-Catenin mutations and expression in hepatocellular carcinoma." Hong Kong : University of Hong Kong, 2000. http://sunzi.lib.hku.hk/hkuto/record.jsp?B24729942.

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34

Hoyos-Flight, Monica. "Wnt signalling and the regulation of the axonal cytoskeleton." Thesis, Imperial College London, 2005. http://hdl.handle.net/10044/1/11773.

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35

Flear, Andrea Karen. "The cytoskeleton during muscle cell fusion in early myogenesis." Thesis, University of Oxford, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.236303.

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36

Shuttleworth, Rebecca Jane. "Role of the chondrocyte cytoskeleton in health and disease." Thesis, Cardiff University, 2010. http://orca.cf.ac.uk/54356/.

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Introduction: Articular cartilage comprises a dense extracellular matrix (ECM) of primarily collagen, proteoglycans and water interspersed with the cartilage cell- the chondrocyte. Osteoarthritis (OA) is a disease characterised by articular cartilage degradation and a change in chondrocyte phenotype. Increased or abnormal joint loading is a risk factor for OA and can regulate chondrocyte phenotype. The chondrocyte cytoskeleton comprises actin microfilaments, tubulin microtubules and vimentin intermediate filaments and has been implicated in the propagation of physical signals to the chondrocyt

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37

Thodey, Catherine. "Actin cytoskeleton dynamics mediate sugar response in Arabidopsis thaliana." Thesis, University of East Anglia, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.518364.

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38

Hawkins, Stephen Francis. "Studies relevant to the cytoskeleton in chronic lymphocytic leukaemia." Thesis, University of Liverpool, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.539727.

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39

KleinJan, Fenneke [Verfasser]. "Viscoelastic and structural properties of the cytoskeleton / Fenneke KleinJan." Ulm : Universität Ulm, 2018. http://d-nb.info/1155827732/34.

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40

Tong, Peter. "Interactions between cell membrane dynamics, the cytoskeleton and insulin." Thesis, University of Newcastle Upon Tyne, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.242381.

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41

Price, Leo Sebastian. "Secretion and the actin cytoskeleton in rat mast cells." Thesis, University College London (University of London), 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.307776.

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42

Filippi, Beatrice Maria. "Cellular effects of phosphoinositide derivatives on the actin cytoskeleton." Thesis, Open University, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.424620.

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43

Rocchetti, Alessandra. "Interactions between the plant Golgi apparatus and the cytoskeleton." Thesis, Oxford Brookes University, 2016. https://radar.brookes.ac.uk/radar/items/e035b419-1acc-4031-aadd-2cfc1f9ed3c8/1/.

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In animal cells, the relationship between the Golgi apparatus and cytoskeleton has been well characterised but not much is known in plants. The functions of the Golgi apparatus are conserved amongst eukaryotes. It is one of the main stations in the secretory pathway and is involved in protein processing and sorting to different destinations. In plants, it is also involved in trafficking and positioning of cell wall components. In tobacco epidermal cells, fluorescent labelling with Golgi marker proteins has shown that the Golgi apparatus is made of hundreds of individual units scattered in the

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44

Dickinson, Sarah. "Regulation of the actin cytoskeleton by ephrin-B signalling." Thesis, University College London (University of London), 2006. http://discovery.ucl.ac.uk/1445415/.

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Ephrin ligands and their Eph receptors play an essential role in angiogenesis during development. Both ephrins and Eph receptors are membrane-tethered proteins and their interaction at sites of cell-cell contact triggers bi-directional signalling, with signals transduced from the receptor (forward signalling) and ligand (reverse signalling). I have used two model systems to study ephrin-B2 signalling: Swiss 3T3 fibroblasts expressing exogenous ephrin-B2 and Human Umbilical Arterial Endothelial Cells (HUAECs) endogenously expressing ephrin-Bs. Stimulation of ephrin-B2 with soluble EphB receptor

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45

Fan, Yi. "POLARIZATION OF CYTOSKELETON-REGULATORY PROTEINS DURING ENDOTHELIAL CELL MIGRATION." Case Western Reserve University School of Graduate Studies / OhioLINK, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=case1247148451.

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46

Caution, Kyle J. "Legionella pneumophila and caspases: modulation of the actin cytoskeleton." The Ohio State University, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=osu1449147516.

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47

Rodrigues, Joana Nogueira. "Dissecting the role of adducin in the axonal cytoskeleton." Master's thesis, Universidade de Aveiro, 2015. http://hdl.handle.net/10773/14771.

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Mestrado em Biologia Molecular e Celular<br>The neuronal cytoskeleton is an interconnected network of filamentous polymers, having in its constitution three major components: actin, microtubules and intermediate filaments. Up to the discovery of axon actin rings, the neuronal actin cytoskeleton has gained relevance. Still, the molecular details of the regulation of the actin cytoskeleton in neurons are largely unknown. Helping in the actin cytoskeleton regulation and maintenance, there is adducin. Adducin is organized in heterotetamers of heterodimers which comprises α/β and α/γ subunit

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48

Pereira, José Carlos Ribeiro Ferreira. "Cytoskeleton regulation in bladder cancer cells after photodynamic treatment." Master's thesis, Universidade de Aveiro, 2016. http://hdl.handle.net/10773/21089.

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Mestrado em Biologia Molecular e Celular<br>A terapia fotodinâmica (PDT) é uma modalidade promissora para o tratamento do cancro. Esta terapia baseia-se na interação entre um composto químico (fotossensibilizador, PS), luz com um determinado comprimento de onda e oxigénio molecular para originar a produção de espécies reativas de oxigénio (ROS). Devido à sua elevada reatividade, estas espécies tóxicas podem causar danos severos conduzindo à morte celular. Atualmente, os PS disponíveis na clínica para o tratamento de tumores apresentam baixa seletividade para as células tumorais. Estudos anteri

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49

Martin, Stuart S. "Phosphoinositide-dependent regulation of the actin cytoskeleton by insulin /." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 1998. http://wwwlib.umi.com/cr/ucsd/fullcit?p9904827.

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50

Zimmerman, Matthew J. "Regulation of the cytoskeleton in human microvascular endothelial cells /." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2000. http://wwwlib.umi.com/cr/ucsd/fullcit?p9956453.

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