Zaloguj się

Gotowe bibliografie tematyczne / D-aspartate / Rozprawy doktorskie

Kliknij ten link, aby zobaczyć inne rodzaje publikacji na ten temat: D-aspartate.

Rozprawy doktorskie na temat „D-aspartate”

Autor: Grafiati

Data publikacji: 4 czerwca 2021

Data aktualizacji: 20 lutego 2023

Utwórz poprawne odniesienie w stylach APA, MLA, Chicago, Harvard i wielu innych

Wybierz rodzaj źródła:

Sprawdź 50 najlepszych rozpraw doktorskich naukowych na temat „D-aspartate”.

Przycisk „Dodaj do bibliografii” jest dostępny obok każdej pracy w bibliografii. Użyj go – a my automatycznie utworzymy odniesienie bibliograficzne do wybranej pracy w stylu cytowania, którego potrzebujesz: APA, MLA, Harvard, Chicago, Vancouver itp.

Możesz również pobrać pełny tekst publikacji naukowej w formacie „.pdf” i przeczytać adnotację do pracy online, jeśli odpowiednie parametry są dostępne w metadanych.

Przeglądaj rozprawy doktorskie z różnych dziedzin i twórz odpowiednie bibliografie.

1

Carlson, Stephen Lee. "Characterization of D-Aspartate Receptor Currents in Aplysia californica." Scholarly Repository, 2010. http://scholarlyrepository.miami.edu/oa_dissertations/478.

Pełny tekst źródła

Streszczenie:

D-Aspartate (D-Asp) is an endogenous compound found in the central nervous system (CNS) of a variety of organisms. Despite its prevalence, however, relatively little understood of its physiological role. The prevailing theory is that D-Asp is an alternate agonist of N-methyl-D-aspartate receptor (NMDAR) channels. The goal of this work was to characterize the currents activated by D-Asp in neurons Aplysia californica, focusing on cells of the buccal S cluster (BSC). First, a general electrophysiological characterization was carried out, examining ion permeability, agonist dose-response, and th

Style APA, Harvard, Vancouver, ISO itp.

2

Sim, Neil. "Molecular imaging probes for N-methyl-D-aspartate receptors." Thesis, Durham University, 2014. http://etheses.dur.ac.uk/10816/.

Pełny tekst źródła

Streszczenie:

The non-invasive detection of neuronal transmission is of prime importance in order to understand brain function better. This will aid cognitive neuroscience, as well as medical science, in the early detection of diseased states. Herein, approaches to molecular imaging of the NMDA receptor, a receptor subtype of the excitatory neurotransmitter glutamate, through the use of targeted contrast agents, is described. Initially, a series of NMDA receptor-targeted MRI contrast agents was developed based upon a known competitive NMDA receptor antagonist, appended to an N-linked ‘Gd-DOTA’ core that pos

Style APA, Harvard, Vancouver, ISO itp.

3

Bera, Katarzyna D. "Autoantibodies to N-methyl D-aspartate receptors in autoimmune encephalitis." Thesis, University of Oxford, 2011. http://ora.ox.ac.uk/objects/uuid:6bbda982-ab5c-4982-b23a-0478c689869c.

Pełny tekst źródła

Streszczenie:

N-methyl-D-aspartate receptor (NMDAR) antibody encephalitis is a recently described autoimmune encephalopathy defined by the presence of serum antibodies that bind NMDARs (NMDAR-Abs). NMDAR-Ab encephalitis is a severe, but treatmentresponsive encephalitis with subacute onset. It can be associated with tumours and affects mainly young adults. Patients present with cognitive dysfunction, seizures, psychiatric and sleep disorders and most develop dyskinesias, autonomic instability and reduced consciousness. To explore further the NMDAR-Abs and their potential pathogenicity, a series of in vitro i

Style APA, Harvard, Vancouver, ISO itp.

4

Yassin, Maged M. I. "N-methyl-D-aspartate, anoxia and glutamate antagonists in mammalian brain." Thesis, Queen's University Belfast, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.241524.

Pełny tekst źródła

Style APA, Harvard, Vancouver, ISO itp.

5

Wu, Y. "Extrasynaptic signalling and plasticity mediated by N-Methyl-D-aspartate receptors." Thesis, University College London (University of London), 2012. http://discovery.ucl.ac.uk/1369568/.

Pełny tekst źródła

Streszczenie:

Synaptic N-Methyl-D-aspartate receptors (NMDARs) are crucial for neural coding and plasticity. However, little is known about the adaptive function of extrasynaptic NMDARs located on the dendritic shaft. Here we find that in CA1 pyramidal neurons backpropagating action potentials (bAPs) recruit shaft NMDARs exposed to ambient glutamate of non-vesicular origin. In contrast, spine NMDARs are "protected" under baseline conditions from such glutamate by perisynaptic transporters: bAP-evoked Ca2+ entry through these receptors can be detected upon synaptic glutamate release or local glutamate uncagi

Style APA, Harvard, Vancouver, ISO itp.

6

Lui, Pik Wa. "Modulation of N-methyl-D-aspartate receptor expression in neuronal cell culture." HKBU Institutional Repository, 2002. http://repository.hkbu.edu.hk/etd_ra/419.

Pełny tekst źródła

Style APA, Harvard, Vancouver, ISO itp.

7

LeMaistre, Jillian. "Regulation of brain blood flow by astrocyte D-serine and N-methyl-D-aspartate receptors." Journal of Cerebral Blood Flow and Metabolism, 2012. http://hdl.handle.net/1993/8585.

Pełny tekst źródła

Streszczenie:

Functional hyperemia is an endogenous regulatory process coupling synaptic activity and elevated neuronal energy demand with increased local blood flow. This involves signalling between neurons, astrocytes and blood vessels, comprising the neurovascular unit. Astrocyte processes ensheath both synapses and blood vessels, permitting multi-modal responses to synaptic activity, where astrocyte cytoplasmic Ca2+ is elevated, triggering endfeet processes to release vasoactive molecules, such as arachidonic acid (AA) metabolites and gliotransmitters, such as D-serine. D-Serine is a co-agonist of the

Style APA, Harvard, Vancouver, ISO itp.

8

Rutter, Anthony Richard. "Biochemical and pharmacological characterisation of the interaction between NMDA receptors and the scaffolding protein PSD-95." Thesis, University College London (University of London), 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.248043.

Pełny tekst źródła

Style APA, Harvard, Vancouver, ISO itp.

9

Kotecha, Suhas Ashok. "G-protein coupled receptor modulation of N-methyl-D-aspartate channel activity." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp05/NQ63766.pdf.

Pełny tekst źródła

Style APA, Harvard, Vancouver, ISO itp.

10

Tofighy, Azita. "N-methyl-d-aspartate receptor desensitisation and anoxia in rat olfactory cortex." Thesis, Queen's University Belfast, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.361309.

Pełny tekst źródła

Style APA, Harvard, Vancouver, ISO itp.

11

Torres, Jacques-Henri. "Récepteur au n-méthyl-d-aspartate et souffrance neuronale du coma hypoglycémique." Montpellier 1, 1988. http://www.theses.fr/1988MON11381.

Pełny tekst źródła

Style APA, Harvard, Vancouver, ISO itp.

12

Elhallaoui, Menana. "Modélisation moléculaire d'antagonistes non compétitifs du récepteur NMDA [N-Méthyl-D-aspartate]." Bordeaux 2, 1994. http://www.theses.fr/1994BOR2B003.

Pełny tekst źródła

Style APA, Harvard, Vancouver, ISO itp.

13

Nixon, Kimberly. "N-methyl-D-aspartate receptor subunit expression following perinatal exposure to ethanol /." Digital version accessible at:, 2000. http://wwwlib.umi.com/cr/utexas/main.

Pełny tekst źródła

Style APA, Harvard, Vancouver, ISO itp.

14

Paliouras, Grigorios Nikiforos. "Effect of ethanol on the Jak-Stat pathway : is this an NMDA mediated event?" Thesis, McGill University, 2002. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=79062.

Pełny tekst źródła

Streszczenie:

Alcohol affects many neurochemical processes, causing long-lasting changes in both the adult and developing brain. The Jak-Stat transcriptional activation pathway plays a role in the control of neuronal proliferation, survival and differentiation, but the effects of ethanol on the system have not been fully elucidated. The goal of this project was to define the effects of acute and subchronic ethanol exposure on the expression of proteins in the Jak-Stat pathway, using cultured NG108-15 cells, and in addition, to test the hypothesis that these effects are mediated through the NMDA recep

Style APA, Harvard, Vancouver, ISO itp.

15

Wenzel, Andreas. "Heterogeneity and developmental regulation of N-methyl-D-aspartate receptors in the brain /." Zürich, 1997. http://e-collection.ethbib.ethz.ch/show?type=diss&nr=12006.

Pełny tekst źródła

Style APA, Harvard, Vancouver, ISO itp.

16

Wilson, John A. "The role of N-methyl D-aspartate (NMDA) receptor antagonists in neuropathic pain." Thesis, University of Edinburgh, 2008. http://hdl.handle.net/1842/25324.

Pełny tekst źródła

Streszczenie:

The aim of this thesis is to investigate the use of NMDAR antagonists in preventing naturopathic sensitisation. The chronic constriction injury (CCI) model of neuropathic pain is used to study the role of NMDARs in the development of neuropathic pain and subsequent modulation. Behavioural effects are assessed in association with changes in NMDAR subtypes. Memantine and ketamine (NMDAR antagonists) are shown to attenuate typical behavioural responses (thermal hyperalgesia and cold allodynia) to nerve injury. In addition, NMDAR antagonist pre-treatment is shown to effect the subsequent NMDAR sub

Style APA, Harvard, Vancouver, ISO itp.

17

Fan, Mannie Man Yee. "Mechanisms of modulation of N-methyl-D-aspartate (NMDA) receptors by mutant huntingtin." Thesis, University of British Columbia, 2007. http://hdl.handle.net/2429/30863.

Pełny tekst źródła

Streszczenie:

Evidence supports a role for neuronal damage arising from excessive activation of glutamate receptors (especially the NMDA subtype) in the pathogenesis of Huntington's disease (HD), although clinical trials involving NMDA receptor inhibition have mostly failed. Further understanding of the underlying molecular mechanisms is therefore needed to refine therapeutic approaches. My work has focused on the elucidation of molecular pathways linking huntingtin (htt) to NMDA receptors (NMDARs). I found that NMDAR subunits NR1/NR2B are shifted from internal pools to the plasma membrane, with fast

Style APA, Harvard, Vancouver, ISO itp.

18

Raouf, Ramin K. "Functional regulation of N-methyl-D-aspartate receptors by serine/threonine protein kinases." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape16/PQDD_0009/MQ29348.pdf.

Pełny tekst źródła

Style APA, Harvard, Vancouver, ISO itp.

19

Lomas, Lisa Madonia Picker Mitchell Jon. "Sex differences in opioid antinociception modulation by the N-methyl-D-aspartate system /." Chapel Hill, N.C. : University of North Carolina at Chapel Hill, 2007. http://dc.lib.unc.edu/u?/etd,1441.

Pełny tekst źródła

Streszczenie:

Thesis (Ph. D.)--University of North Carolina at Chapel Hill, 2007.<br>Title from electronic title page (viewed Apr. 25, 2008). "... in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the Department of Psychology Behavioral Neuroscience." Discipline: Psychology; Department/School: Psychology.

Style APA, Harvard, Vancouver, ISO itp.

20

Morgan, Elaine M. "The role of nitric oxide in N-methyl-D-aspartate receptor-mediated neurotoxicity." Thesis, University of Southampton, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.243084.

Pełny tekst źródła

Style APA, Harvard, Vancouver, ISO itp.

21

Jocoy, Emily Laura. "NR2 subunits and their role in striatal N-methyl-D-aspartate receptor function." Diss., Restricted to subscribing institutions, 2009. http://proquest.umi.com/pqdweb?did=1872142721&sid=9&Fmt=2&clientId=1564&RQT=309&VName=PQD.

Pełny tekst źródła

Style APA, Harvard, Vancouver, ISO itp.

22

Jezequel, Julie. "Impact of psychotomimetic molecules on glutamatergic N-Methyl-D-Aspartate receptors surface trafficking." Thesis, Bordeaux, 2016. http://www.theses.fr/2016BORD0232/document.

Pełny tekst źródła

Streszczenie:

Les récepteurs glutamatergiques de type N-Méthyl-D-Aspartate (RNMDA) jouent un rôle majeur dans de nombreux processus physiologiques, et leur implication dans la physiopathologie de certains troubles neuropsychiatriques tels que la schizophrénie est suggérée par un robuste faisceau de données cliniques et précliniques. Cependant, les mécanismes cellulaires et moléculaires conduisant à une telle dérégulation des RNMDA restent inexpliqués. La diffusion membranaire, mécanisme de contrôle spatial et temporel de la distribution des RNMDA à la surface des neurones, constitue un puissant régulateur d

Style APA, Harvard, Vancouver, ISO itp.

23

Steinmetz, Ralf Dirk. "Functional expression of recombinant N-methyl-D-aspartate (NMDA) receptors in eukaryotic cell lines." [S.l.] : [s.n.], 2000. http://deposit.ddb.de/cgi-bin/dokserv?idn=961238070.

Pełny tekst źródła

Style APA, Harvard, Vancouver, ISO itp.

24

King, Rachel Marie. "NR2Aand NR2B containing N-methyl-D-aspartate receptors in synaptic plasticity during cortical development." Thesis, University of Bristol, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.520637.

Pełny tekst źródła

Style APA, Harvard, Vancouver, ISO itp.

25

Riedemann, Maria-Therese. "Corticosterone-induced changes in N-methyl-D-aspartate receptor-mediated transmission in the hippocampus." Thesis, University of Bristol, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.550309.

Pełny tekst źródła

Streszczenie:

Due to its great importance in learning and memory, the hippocampus has received a lot of attention from studies investigating synaptic plasticity, the molecular correlates of learning and memory. Corticosterone (CaRT) is the endogenous glucocorticoid in rodents and is of high physiological significance to the organism. In response to stress the glucocorticoid concentration rises rapidly, releasing the hormone into the blood and allowing it to exert its actions on the level of the pituitary, the hypothalamus and the hippocampus. Interestingly, learning and memory are also subject to glucocorti

Style APA, Harvard, Vancouver, ISO itp.

26

Foster, Brett Lucas. "Modulation of resting human electroencephalographic dynamics by N-methyl-D-aspartate Antagonist Nitrous Oxide." Swinburne Research Bank, 2009. http://hdl.handle.net/1959.3/69924.

Pełny tekst źródła

Streszczenie:

Thesis (PhD) - Swinburne University of Technology, Brain Sciences Institute, 2009.<br>A thesis submitted for the degree of Doctorate of Philosophy, Brain Sciences Institute, Swinburne University of Technology - 2009. Typescript. Bibliography: p. 153-183.

Style APA, Harvard, Vancouver, ISO itp.

27

Bright, Nieka L. "Glutamate Receptor, Ionotropic N-methyl-D-aspartate 2B Polymorphisms and Concussive Recovery in Athletes." Diss., Temple University Libraries, 2013. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/216565.

Pełny tekst źródła

Streszczenie:

Kinesiology<br>Ph.D.<br>Athletes vary in their ability to recover from concussions. Following a concussion, a pathophysiological cascade of events transpires, rendering symptoms. One such event, the indiscriminate release of the excitatory neurotransmitter glutamate, may result in hyperactivation of glutamate receptors (e.g., N-methyl-D-aspartate receptors [NMDARs]) and self-propagate a state of neurotoxicity that may be enhanced via the concomitant release of Ca2+, particularly through NMDARs containing the NR2B subunit. Genetic variation in regulatory regions of the glutamate receptor, ionot

Style APA, Harvard, Vancouver, ISO itp.

28

Vasuta, Oana Cristina. "Functional regulation of N-methyl-D-aspartate receptor subtypes and their involvement in hippocampal plasticity." Thesis, University of British Columbia, 2009. http://hdl.handle.net/2429/17410.

Pełny tekst źródła

Streszczenie:

Regulation of NMDAR activity by desensitization is important in physiological and pathological states. We previously reported that desensitization decreases during hippocampal neuronal development, correlating with NMDAR composition, synaptic localization and association with PSD-95. To determine if PSD-95-induced changes in NMDAR desensitization occur because of direct binding to NR2 subunits or due to recruitment of regulatory proteins, we tested the effects of various PSD-95 constructs on NMDAR currents in HEK293 cells and neurons. In HEK cells, wt PSD-95 significantly reduced wt NMDAR dese

Style APA, Harvard, Vancouver, ISO itp.

29

She, Kevin. "N-methyl-D-aspartate receptors of the central nervous system : network connectivity, trafficking, and plasticity." Thesis, University of British Columbia, 2012. http://hdl.handle.net/2429/43286.

Pełny tekst źródła

Streszczenie:

Activity through NMDA type glutamate receptors sculpts connectivity in the developing nervous system and is typically studied in the visual system in vivo where individual synapses are difficult to visualize. Here, we developed a model of NMDA-receptor dependent synaptic competition in dissociated cultured hippocampal neurons. GluN1 -/- (KO) mouse hippocampal neurons were cultured alone or in defined ratios with wild type (WT) neurons. Synapse development was assessed by immunofluorescence for PSD-95 apposed to VGlut1. Synapse density was specifically enhanced only onto minority WT neurons co-

Style APA, Harvard, Vancouver, ISO itp.

30

Reynolds, Anna R. "Examination of Hippocampal N-Methyl-D-Aspartate Receptors Following Chronic Intermittent Ethanol Exposure In Vitro." UKnowledge, 2013. http://uknowledge.uky.edu/psychology_etds/14.

Pełny tekst źródła

Streszczenie:

Chronic intermittent ethanol exposure (CIE) is associated with degeneration of hippocampal neurons. The present study used hippocampal cultures to examine the loss of NeuN immunoreactivity, a relaible marker or neuronal density, after 1, 2, or 3 cycles of 5 days EtOH exposure (50 mM), followed by a 24-hour period of EWD or continuous EtOH exposure. NeuN immunoreactivity was decreased by 13%, 19%, and 16% in the CA1, CA3, and dentate gyrus after 3 cycles of CIE respectively; thionine staining confirmed significant cellular losses within each hippocampal subregion. Two cycles of CIE in aged tiss

Style APA, Harvard, Vancouver, ISO itp.

31

Semos, Madeline Louise. "The role of N-methyl-D-aspartate receptors and nitric oxide in spinal nociceptive processing." Thesis, University of Bristol, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.294627.

Pełny tekst źródła

Style APA, Harvard, Vancouver, ISO itp.

32

Hobbs, Catherine M. "The functional expression of N-methyl-D-aspartate glutamate-type receptors by megakaryocytes and platelets." Thesis, University of Bath, 2010. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.527791.

Pełny tekst źródła

Streszczenie:

This study investigated the role of NMDARs in the differentiation of MEG-01 cells and in the activation of human platelets. This investigation demonstrated that the NR1, NR2D and NR3 subunit proteins are expressed in human platelets, with the NR1 subunit also expressed in MEG-01 cells. The NR2A subunit protein was not detectable in either MEG-01 cells or human platelets. PMA-induced differentiation of MEG-01 cells did not appear to stimulate changes in expression of any of the subunit proteins tested. Using assays to measure the changes in [Ca2+]i and ATP secretion, it was determined that dono

Style APA, Harvard, Vancouver, ISO itp.

33

Thouin, Anaïs Chiara. "Investigating the effects of N-methyl-D-aspartate receptor autoantibodies on cortical oscillations in vitro." Thesis, University of Newcastle upon Tyne, 2017. http://hdl.handle.net/10443/3730.

Pełny tekst źródła

Streszczenie:

N-methyl-D-Aspartate receptors (NMDARs) play a key role in memory formation and learning, and modulate gamma-frequency oscillations (-: 30-80Hz). Gamma-oscillations are important in perception, cognition and memory formation. They are disrupted in patients with schizophrenia, in whom NMDAR hypofunction has been posited, and in animal models of schizophrenia. Furthermore, NMDAR antagonists reduce -oscillation power and frequency in vitro. NMDA receptor antibody (NMDAR-Ab) encephalitis recapitulates some of the features seen with blockade or ablation of NMDARs, including anterograde memory los

Style APA, Harvard, Vancouver, ISO itp.

34

Wendt, Stefan [Verfasser]. "Microglia sense cortical spreading depression via N-methyl-D-aspartate receptor dependent potassium currents / Stefan Wendt." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2017. http://d-nb.info/1133074367/34.

Pełny tekst źródła

Style APA, Harvard, Vancouver, ISO itp.

35

Ward, Amie S. (Amie Sue). "Characterization of Tolerance and Cross-tolerance between Noncompetitive N-methyl-D-aspartate (NMDA) Antagonists in Rats Trained to Self-administer Ketamine." Thesis, University of North Texas, 1995. https://digital.library.unt.edu/ark:/67531/metadc278135/.

Pełny tekst źródła

Streszczenie:

Ketamine and phencyclidine (PCP) are noncompetitive antagonists of the N-methyl-D-aspartate (NMDA) type of ligand-gated glutamate receptors. Both agents have high abuse liability, and may produce dependence. Tolerance to the reinforcing effects of drugs of abuse is widely regarded as a key component of the dependence process. Therefore, the present study was conducted to examine whether tolerance develops to the reinforcing effects of ketamine, and whether PCP and dizocilpine, a noncompetitive NMDA antagonist with negligible abuse liability, produce cross-tolerance to the reinforcing effects o

Style APA, Harvard, Vancouver, ISO itp.

36

Meddows, Elisabeth. "Identification of the molecular determinants important in the assembly of N-methyl-D-aspartate (NMDA) receptors." Thesis, University of Oxford, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.365682.

Pełny tekst źródła

Style APA, Harvard, Vancouver, ISO itp.

37

Ring, Joshua Roderick. "SYNTHETIC AROMATIC AGMATINE ANALOGS AS ALLOSTERIC MODULATORS OF THE N-METHYL-D-ASPARTATE (NMDA) RECEPTOR CHANNEL." UKnowledge, 2006. http://uknowledge.uky.edu/gradschool_diss/413.

Pełny tekst źródła

Streszczenie:

The N-methyl-D-aspartate (NMDA) receptors are highly regulated ligand-gated ion channels, which are affected by many substrates. Overactivation of the NMDA receptor can lead to hyperexcitability and a number of neurotoxic effects and neurological diseases. Agmatine has been demonstrated to act allosterically as an inhibitory modulator at the polyamine recognition sites of the NMDA receptor complex. The present study synthesized and evaluated a library of agmatine analogs for their ability to displace tritiated MK-801 from NMDARs in P2 membrane preparations from rat brains at ligand concentrati

Style APA, Harvard, Vancouver, ISO itp.

38

Berry, Jennifer Nicole. "TIME-DEPENDENCE OF DISTAL-TO-PROXIMAL HIPPOCAMPAL NEURODEGENERATION PRODUCED BY N-METHYL-D-ASPARTATE RECEPTOR ACTIVATION." UKnowledge, 2010. http://uknowledge.uky.edu/gradschool_theses/72.

Pełny tekst źródła

Streszczenie:

Excitotoxicity is the overexcitation of neurons due to the excessive activation of excitatory amino acid receptors and is thought to be involved in many neurodegenerative states. The manner in which the neuron breaks down during excitotoxicity is still unclear. The current study used the organotypic hippocampal slice culture model to examine the time-dependent loss of the synaptic vesicular protein synaptophysin and the loss of N-methyl-D-aspartate (NMDA) receptor NR1 subunit availability following an excitotoxic insult (20 μM NMDA) to provide a better understanding of the topographical nature

Style APA, Harvard, Vancouver, ISO itp.

39

Davidson, Avril. "A biochemical investigation of the N-methyl-D-aspartate receptor in the rat central nervous system." Thesis, University of Edinburgh, 1993. http://hdl.handle.net/1842/19668.

Pełny tekst źródła

Streszczenie:

Activation of the N-methyl-D-aspartate(NMDA) receptor is important in both physiological and pathological phenomena, including synaptogenesis, long-term potentiation, neuroexcitotoxicity and epilepsy. Although implicated in postnatal formation of synaptic connections, over-activation of the NMDA receptor in the neonate, as a result of say a hypoxic-ischaemic insult, can lead to neuronal damage. Antagonists for specific sites on the NMDA receptor complex may therefore prove to be novel therapeutic agents for preventing excitotoxic neuronal damage. I have therefore investigated the ontogeny of t

Style APA, Harvard, Vancouver, ISO itp.

40

Martin, Elodie. "Etude de l'impact des antagonistes du récepteur N-méthyl-D-aspartate (NMDA) dans la douleur neuropathique." Thesis, Université Clermont Auvergne‎ (2017-2020), 2017. http://www.theses.fr/2017CLFAS012.

Pełny tekst źródła

Streszczenie:

Les antagonistes du récepteur N-méthyl-D-aspartate (NMDA) comme la kétamine, le dextrométhorphane et la mémantine sont utilisés pour la prise en charge de la douleur neuropathique. La kétamine est très efficace contre les douleurs neuropathiques réfractaires aux traitements conventionnels. Cependant, son utilisation est limitée du fait de nombreux effets indésirables. Un relais antalgique est alors proposé. Ce travail de thèse s’insère dans un programme de recherche dédié aux antagonistes du récepteur NMDA dans la prise en charge de la douleur neuropathique. Le premier objectif était d’évaluer

Style APA, Harvard, Vancouver, ISO itp.

41

Yongtao, Zhang, and Zhang Yongtao. "Synthesis and structural characterization of silver (I)-(D-, L- and DL-) aspartate and silver (I)-(D- and L-) glutamate coordination polymers." Thesis, The University of Arizona, 2017. http://hdl.handle.net/10150/626799.

Pełny tekst źródła

Streszczenie:

Chiral assemblies of metal atoms linked by organic ligands are attracting considerable attention for their unique structural aesthetics and interesting properties. In order to explore the novel helical supramolecular of silver with amino acid complexes and develop the potential applications of them, the silver nitrate and two types of amino acid (L-, D- and DL-) aspartic acid and (L- and D-) glutamic acid are used to generate chiral silver(I) coordination polymers. In this work, five coordination polymers, {[Ag3(D-Asp)2(NO3)]}n. nH2O (1), {[Ag3(L-Asp)2(NO3)]}n. nH2O (2), {[Ag4(DL-Asp)2(NO3)2]}

Style APA, Harvard, Vancouver, ISO itp.

42

Dumontet, Charles. "Acide d-aspartique beta-hydroxamate : essai clinique de phase i/ii chez les patients atteints de sida." Lyon 1, 1991. http://www.theses.fr/1991LYO1M069.

Pełny tekst źródła

Style APA, Harvard, Vancouver, ISO itp.

43

Greyling, Yolande. "N-methyl-D-aspartate (NMDA) and sigma receptor antagonism as neuroprotective strategy for polycyclic amines / Yolande Greyling." Thesis, North-West University, 2008. http://hdl.handle.net/10394/4202.

Pełny tekst źródła

Streszczenie:

Polycyclic cage compounds and their effects on different receptors and receptor channels have been studied extensively. It is evident that these compounds may prove to be of great value in future treatment of neurodegenerative diseases. Although many of the mechanisms involved in the process of neurodegeneration are still not fully elucidated, researchers are getting closer to identifying more and new possible targets for drug treatment. In this study the focus was mainly on the effect of polycyclic cage compounds on calcium homeostasis, a key process in neurodegeneration. The role of sigma re

Style APA, Harvard, Vancouver, ISO itp.

44

Morgan, Celia Janet Ann. "An investigation of the acute and chronic effects of the N-methyl-D-aspartate receptor antagonist ketamine." Thesis, University College London (University of London), 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.429564.

Pełny tekst źródła

Style APA, Harvard, Vancouver, ISO itp.

45

Dorville, Agnès. "Optimisation des propriétés des antagonistes des récepteurs N-méthyl-D-aspartate et cholecystokinine-B par modélisation moléculaire." Paris 5, 1993. http://www.theses.fr/1993PA05P608.

Pełny tekst źródła

Style APA, Harvard, Vancouver, ISO itp.

46

Morel, Véronique. "Approche translationnelle de l'impact des antagonistes du récepteur NMDA (N-méthyl-D-aspartate) dans la douleur neuropathique." Thesis, Clermont-Ferrand 1, 2014. http://www.theses.fr/2014CLF1MM07.

Pełny tekst źródła

Streszczenie:

Les antagonistes du récepteur NMDA sont des molécules intéressantes dans la prise en charge des douleurs neuropathiques. Certaines d’entre elles, comme la kétamine, génèrent de nombreux effets indésirables, limitant leur utilisation en clinique. D’autres comme la mémantine ou le dextrométhorphane, ont fait l’objet de nombreuses études précliniques et cliniques aux résultats controversés. L’objectif de ce travail était de déterminer l’impact de ces deux molécules sur la douleur neuropathique en évaluant leurs effets antinociceptifs, cognitifs, et les événements cellulaires associés au récepteur

Style APA, Harvard, Vancouver, ISO itp.

47

Abu, Izuddin Fahmy. "Exploring block and permeation of N-methyl-D-Aspartate (NMDA) receptor channels for treatment of neurodegenerative disorders." Thesis, University of Nottingham, 2016. http://eprints.nottingham.ac.uk/38591/.

Pełny tekst źródła

Streszczenie:

N-methyl-D-aspartate receptors (NMDAR) are ionotropic glutamate receptors which can be blocked by Mg2+ in a voltage-dependent manner and are highly permeable to Ca2+, hence they represent a medically relevant target for neurodegenerative disorders caused by excitotoxicity. The two main objectives of this study were, (i) to determine the impact of Q/R/N, +1 and -8 sites modification in the M2 pore region of GluN2A NMDAR subunit on Mg2+ block and other open channel blockers; and (ii) to evaluate novel multi-target-directed ligands (MTDL) for Alzheimer’s disease therapy. The Xenopus laevis oocyte

Style APA, Harvard, Vancouver, ISO itp.

48

Lau, Wai Kit Jaeger. "Developmental expression of N-methyl-D-aspartate and gamma-aminobutyric acid receptors in the rat basal ganglia." HKBU Institutional Repository, 2004. http://repository.hkbu.edu.hk/etd_ra/535.

Pełny tekst źródła

Style APA, Harvard, Vancouver, ISO itp.

49

Braganza, Elena Marie [Verfasser]. "Influence of the N-Methyl-D-Aspartate Receptor coagonist, D-Cycloserine, on Memory Consolidation and subsequent Learning under Sleep Deprivation / Elena Marie Braganza." Tübingen : Universitätsbibliothek Tübingen, 2020. http://d-nb.info/1224232801/34.

Pełny tekst źródła

Style APA, Harvard, Vancouver, ISO itp.

50

Martel, Marc-Andre´. "Role of the NR2 subunit composition and intracellular C-terminal domain in N-methy-D-aspartate receptor signalling." Thesis, University of Edinburgh, 2009. http://hdl.handle.net/1842/4228.

Pełny tekst źródła

Streszczenie:

N-methyl-D-aspartate receptors (NMDARs) are glutamate-gated ionotropic receptors. When activated, NMDARs let extracellular sodium and calcium ions enter neurons. This calcium influx, depending on its duration, intensity and the presence of nearby signalling proteins can signal to synaptic plasticity. Additionally, physiological NMDAR activity promotes pro-survival cascades and gene transcription, whereas both lack of activation and overactivation of these receptors trigger pro-death signals. Several neurodegenerative pathologies such as stroke/ischemia and Alzheimer’s disease are thought to in

Style APA, Harvard, Vancouver, ISO itp.

Oferujemy zniżki na wszystkie plany premium dla autorów, których prace zostały uwzględnione w tematycznych zestawieniach literatury. Skontaktuj się z nami, aby uzyskać unikalny kod promocyjny!