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Rozprawy doktorskie na temat „D1 cells”

Autor: Grafiati

Data publikacji: 3 czerwca 2025

Data aktualizacji: 31 lipca 2025

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1

Wood, Eleanor Jane. "Phospholipase D1 dynamics in animal cells." Thesis, University of Cambridge, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.614780.

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Kennedy, Christopher R. J. "Signalling pathways of bradykinin-mediated arachidonic acid release in MDCK-D1 cells." Thesis, University of Ottawa (Canada), 1997. http://hdl.handle.net/10393/4074.

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An investigation was undertaken to elucidate the signal transduction pathways involved in bradykinin (BK)-mediated release of arachidonic acid (AA) from the D1 clone of Madin-Darby canine kidney cells (MDCK-D1) which display distal tubule- and cortical collecting duct principal cell-like characteristics. Prostaglandins (PG), generated subsequent to BK stimulation, are known to modulate arginine-vasopressin (AVP)-stimulated water flow across this portion of the nephron. The enzyme immediately responsible for AA release was determined to be the 85 kDa cytosolic phospholipase A$\sb2$ (cPLA$\sb2),

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Kennedy, Chris R. J. "Signalling pathways of bradykinin-mediated arachidonic acid release in MDCK-D1 cells." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/nq21003.pdf.

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4

Benitez-Rajal, Joaquin. "Phospholipase D1 : a possible role in nucleotide-mediated hepatic stellate cell contraction." Thesis, University of Newcastle Upon Tyne, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.366643.

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Matsuo, Koji. "Significance of dopamine D1 receptor signalling for steroidogenic differentiation of human induced pluripotent stem cells." Kyoto University, 2018. http://hdl.handle.net/2433/232124.

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6

Misiuta, Iwona E. "Characterization of the Dopaminergic Potential of the Human NTera2/D1 (NT2) Cell Line In Vitro." [Tampa, Fla.] : University of South Florida, 2005. http://purl.fcla.edu/fcla/etd/SFE0001184.

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吳毅賢 and Samuel Ng. "Extracellular calcium in dopamine D1-receptor mediated growth hormone release from Chinese grass carp pituitary cells." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1997. http://hub.hku.hk/bib/B31219755.

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Ng, Samuel. "Extracellular calcium in dopamine D1-receptor mediated growth hormone release from Chinese grass carp pituitary cells /." Hong Kong : University of Hong Kong, 1997. http://sunzi.lib.hku.hk/hkuto/record.jsp?B1947104X.

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9

Kruse, Maria Sol. "Plasticity of the dopamine 1 receptor and its signaling pathway /." Stockholm, 2003. http://diss.kib.ki.se/2003/91-7349-652-9/.

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10

Verardi, Laura <1988&gt. "The Function of Cyclin D1 in DNA Repair: A New Possible Approach to Increase Sensitivity of Ovarian Cancer Cells to Irradiation." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2017. http://amsdottorato.unibo.it/8070/1/Verardi_Laura_tesi.pdf.

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Cyclin D1 has been recently investigated as an important protein in homologous recombination-directed repair (HDR) mechanism. Cyclin D1 is recruited to damaged foci by BRCA2 and it enhances RAD51 binding to BRCA2. Furthermore, cyclin D1 is essential for RAD51 gene up-regulation in case of double-stranded break (DSB). Meanwhile molecule 3l, an E-3-(2-chloro-3-indolylmethylene)1,3-dihydroindol-2one, has been showed to reduce cyclin D1 level and, for this reason, 3l treatment could be used to study cyclin D1 role in DNA damage repair. Scope of this thesis is to find a new possible combined appro

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11

Saturno, Juvaní Lago. "Análise imuno-histoquímica da Bcl-2, Bcl-6, c-Myc e ciclina D1 em linfomas de células B da região oral." Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/23/23141/tde-06082014-144841/.

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Neste trabalho foram analisados 30 casos de linfomas de células B da região oral, fixados em solução de formaldeído e incluídos em parafina, através da técnica de imuno-histoquímica para as proteínas c-Myc, Bcl-2, Bcl-6 e ciclina D1. Dos casos analisados 40% foram positivos para a marcação para c-Myc, 33,3% para a marcação para ciclina D1, 83,3% para a marcação para Bcl-2 e 53,3% para a marcação para Bcl-6. Todos os casos foram diagnosticados como linfomas difusos de grandes células B, o subtipo de linfoma com a maior casuística. A análise destas proteínas é de fundamental importância para o d

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12

Bittencourt, Danielle. "Coupling between gene expression steps in mammalian cells : role of transcriptional coregulators and physio-pathological impact." Paris 7, 2008. http://www.theses.fr/2008PA077124.

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J'ai étudié la régulation de l'expression génique en réponse à une hormone stéroïde, l'estradiol, pour trois gènes modèles en prenant en compte fensernbte des étapes impliquées, J'ai pu montrer que l’épissage co-transcriptionnelle est plus efficace dans le cas de la cyctîne 01 par rapport à pS2 et potentialise la production de l’ARNrn de la cycline D1. Ce travail montre que, in vivo, la coordination entre la transcription et l’épissage est nécessaire à la production efficace d’ ARNm en réponse à un stimulus transcriptionnel. Afin de déterminer les acteurs moléculaires responsables du couplage

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Sperandio, Felipe Fornias. "Análise da expressão e mecanismos de ação das proteínas Akt, Hsp90, mTOR e ciclina D1 em cultura de células de carcinoma epidermoide humano e células displásicas após irradiação com laser em baixa intensidade." Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/23/23141/tde-13042013-102741/.

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O carcinoma de cabeça e pescoço é uma neoplasia maligna de origem epitelial que resulta em aproximadamente 500.000 novos casos por ano ao redor do mundo. Diversos estudos têm sido conduzidos de maneira a elucidar os mecanismos de proliferação e invasão desta doença, sendo a via de sinalização Akt/mTOR e proteínas relacionadas, apontada como uma das principais vias envolvidas em sua progressão. Sabe-se que células neoplásicas, bem como células de diferentes tecidos, podem ter seu comportamento modificado após terem sido irradiadas com laser em baixa intensidade (LLLT). Porém, os mecanismos de a

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14

Huang, Jui-Wen. "Part 1: Troglitazone analogues as cyclin D1 ablative agents: the potential drugs for breast cancer therapy Part 2: Vitamin E and its analogues induce apoptosis in prostate cancer cells in part through inhibition of Bcl-2/Bcl-XL functions /." Columbus, Ohio : Ohio State University, 2005. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1128050561.

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15

Kotowski, Sarah. "Regulation of dopamine signaling by D1 receptor membrane trafficking." Diss., Search in ProQuest Dissertations & Theses. UC Only, 2009. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3390053.

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16

Lima, Marcela Sampaio. "Expressão de Ciclina D1 em Carcinoma de Células Renais." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/17/17143/tde-21102013-215129/.

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Carcinoma de Células Renais (CCR) representa uma família de tumores distintos com evolução clínica imprevisível. Uma variedade de moléculas tem sido avaliada como marcadores prognósticos para CCR. Ciclina D1, uma proteína reguladora do ciclo celular, encontra-se superexpressa em vários tumores primários. Nosso objetivo é avaliar sua expressão como marcador prognóstico em CCR. Antes disso, traçamos um perfil clínico e histopatológico da amostra e verificamos sua relação com os fatores prognósticos considerados clássicos pela literatura. 109 espécimes de pacientes diagnosticados com CCR foram ob

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17

Zarkowska, Tamara Anna. "Phosphorylation of the retinoblastoma protein, pRB, by CDK4-cyclin D1." Thesis, Institute of Cancer Research (University Of London), 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.321951.

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18

Salinas, Daniel Cirera. "miR-33 regulates cell proliferation, cell cycle progression and liver regeneration." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2013. http://dx.doi.org/10.18452/16721.

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Der Cholesterin-Stoffwechsel ist sehr streng auf zellulärer Ebene reguliert und ist essentiell für das Zellwachstum. MicroRNAs (miRNAs), eine Klasse nicht-kodierender RNAs, wurden als kritische Regulatoren der Genexpression identifiziert und entfalten ihre Wirkung vorwiegend auf posttranskriptioneller Ebene. Aktuelle Arbeiten aus der Gruppe um Fernández-Hernando haben gezeigt, dass hsa-miR-33a und hsa-miR-33b, miRNAs die in den Intronsequenzen der Gene für die Sterol-regulatorischen Element- Bindungsproteine (SREBP-2 und SREBP -1) lokalisiert sind, den Cholesterin-Stoffwechsel im Einkl

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19

Oliveira, Da Cruz Jose Fernando. "Cell-type specific CB1 receptor modulation of hippocampal synaptic plasticity and memory." Thesis, Bordeaux, 2017. http://www.theses.fr/2017BORD0905.

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Le système endocannabinoïde est un système neuromodulateur majeur du cerveau. Ainsi, il contrôle la mémoire et l’apprentissage, et ce, principalement par l'intermédiaire des récepteurs aux cannabinoïdes de type 1 (CB1) qui régulent de manière fine les activités neuronales et gliales. Dans l’hippocampe, une communication bidirectionnelle entre neurones et astrocytes modèle la plasticité synaptique et le comportement. Il a été rapporté que les effets disruptifs des cannabinoïdes sur la plasticité synaptique et la mémoire de travail sont dépendants de récepteurs CB1 présents dans les astrocytes.

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20

Miloudi, Hadjer. "Étude des anomalies de XPO1 dans les lymphomes B Anomalies de l’exportine 1 dans les he´mopathies malignes : des mutations au ciblage the´rapeutique Cytoplasmic cyclin D1 controls the migration and invasiveness of mantle lymphoma cells STAT6 is a cargo of exportin 1: Biological relevance in primary mediastinal B-cell lymphoma Mutant E571K and wild-type XPO1 effects are balanced in B-cell lymphoma." Thesis, Normandie, 2020. http://www.theses.fr/2020NORMC409.

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L'exportine-1 (ou XPO1) joue un rôle clé dans le transport de nombreux ARN et près de 200 protéines cargos. La mutation « hot-spot » XPO1-E571K est présente chez près de 25% des patients atteints par le lymphome primitif du médiastin (PMBL) et la forme classique du lymphome de hodgkin (cHL), et à plus faible fréquence dans la leucémie lymphoïde chronique (LLC) (3%). Des mutations touchant la voie JAK2/STAT6 sont aussi retrouvées dans le PMBL et le cHL. C’est pourquoi nous avons étudié l’implication de XPO1 dans la voie JAK2/STAT6. Nous avons montré que STAT6 est une protéine cargo de XPO1 par

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21

PETRE, CHRISTIN ELIZABETH. "CYCLIN D1: MECHANISM AND CONSEQUENCE OF ANDROGEN RECEPTOR CO-REPRESSOR ACTIVITY IN PROSTATIC ADENOCARCINOMA." University of Cincinnati / OhioLINK, 2004. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1085487395.

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22

Parinyapong, Piyarat. "An analysis of Antirrhinum majus cyclin A20 and cyclin D1 function in Arabidopsis thaliana." Thesis, University of Liverpool, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.250374.

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23

Peurala, E. (Emmi). "Regulators of hypoxia response and the cell cycle in breast cancer." Doctoral thesis, Oulun yliopisto, 2013. http://urn.fi/urn:isbn:9789526202709.

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Abstract Breast cancer is the most common cancer affecting the female population of the Western world. It is a heterogeneous disease entity that encompasses tumors with remarkably different forms of behaviour, and it is therefore vital to distinguish patients with good and poor prognoses. The classical prognostic and predictive factors for breast cancer serve as tools for clinical oncologists when planning treatment, but the growing awareness of breast cancer biology is bringing about a need for novel prognostic and predictive biomarkers. This thesis examines the prognostic significance of hyp

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Albero, Gallego Robert. "Mantle cell lymphoma pathogenesis: another turn of the screw to cyclin D1 overexpression." Doctoral thesis, Universitat de Barcelona, 2017. http://hdl.handle.net/10803/565574.

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Mantle cell lymphoma (MCL) is an aggressive lymphoid neoplasm derived from mature B cells characterized by the presence of the t(11;14)(q13;q32) translocation that leads to the overexpression of Cyclin D1. Cyclin D1 plays a well-established role in G1/S progression, although other functions including transcription or DNA damage response (DDR) can be regulated by this cyclin. Therefore, the main goal of this thesis is the characterization of the cyclin D1 non-canonical function in MCL and lymphoid cells. Firstly, we analyzed the genomic binding of endogenous cyclin D1 in four MCL cell lines

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Andrews, Anton Oguzhan Alford. "A study of cyclin D1 and its role in the mammalian cell cycle." Thesis, King's College London (University of London), 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.362382.

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Zhang, Dongling. "Delineation of the structure-function relationships within the fourth intracellular loop of dopamine D1-like receptors." Thesis, University of Ottawa (Canada), 2004. http://hdl.handle.net/10393/26823.

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The present study focuses the attention on a region of CT known to participate in the formation of a fourth intracellular loop (IL.4). The central objective of this study is to investigate the potential role of variant residues within IL4 region in regulating distinct D1-like functional properties. Results obtained from ligand binding and agonist-dependent G protein coupling studies using chimeric receptors reveal a crucial role of the N-terminal segment of IL4 (IL4N) in regulating receptor expression, ligand binding and dopamine (DA) potency of D1-like subtypes. Moreover, results show that th

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Josè, Fernando Oliveira Da Cruz. "Cell-type specific CB1 receptor modulation of hippocampal synaptic plasticity and memory." Doctoral thesis, Università di Catania, 2017. http://hdl.handle.net/10761/3982.

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The endocannabinoid system is a major brain modulatory system that controls memory and learning mainly via the cannabinoid receptor type 1 (CB1)-dependent regulation of neuronal and glial activity. In the hippocampus, bidirectional communication between neurons and astrocytes shapes synaptic plasticity and behavior. CB1 receptors have been shown to be present in the astrocytes and to mediate the disruptive effects of cannabinoids in synaptic plasticity and working memory. Yet, it is not currently known the role of this receptor in the physiological modulation of memory processes. Also, previou

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Dunphy, Elizabeth Louise. "TAF1 HAT activity in cell proliferation /." Thesis, Connect to this title online; UW restricted, 2003. http://hdl.handle.net/1773/6250.

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Tut, Vivienne Mai. "Cyclins A and D1 in human bladder cancer and their relationship to cell proliferation." Thesis, University of Newcastle Upon Tyne, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.391399.

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Mastrandrea, Nicholas Joseph. "Pentoxifylline As An Adjuvant Treatment In Renal Cell Carcinoma." Diss., The University of Arizona, 2014. http://hdl.handle.net/10150/337293.

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Cyclin D1, a proto-oncogene, is required for progression from the G1 phase into the S phase of the cell cycle. Over-expression of cyclin D1 causes an increase in cell cycle progression and cell proliferation, implicating it in a variety of cancers including renal cell carcinoma (RCC). The rodent RCC cell model, QTRRE, and human RCC cell models, ACHN, 786-O and Caki-2, exhibit elevated levels of cyclin D1. Pentoxifylline (PTX), a non-specific phosphodiesterase inhibitor, is an FDA-approved hemorheologic agent used to treat intermittent claudication, stemming from peripheral vascular diseases, a

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Nai, Gisele Alborghetti. "O possível papel da proteína ROC1 na expressão da proteína ciclina D1 em melanomas cutâneos /." Botucatu : [s.n.], 2009. http://hdl.handle.net/11449/104578.

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Orientador: Mariângela Esther Alencar Marques<br>Banca: Luciana Patrícia Fernandes Abbade<br>Banca: Luís Fernando Barbisan<br>Banca: Mírian Nacagami Sotto<br>Banca: Cleverson Teixeira Soares<br>Resumo: O aumento da expressão de ciclina D1, demonstrado em melanomas cutâneos, provavelmente está relacionado ao potencial invasivo do tumor. A diminuição da proteína ROC1, envolvida na degradação da ciclina D1, pode constituir uma alternativa para explicar o aumento desta proteína na ausência de superexpressão gênica. O objetivo deste estudo foi avaliar a relação da proteína ROC1 com a expressão de c

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Liu, Hui. "The molecular mechanisms of cyclin D1 gene deregulation by immunoglobulin regulatory sequences in B cell malignancies." Diss., The University of Arizona, 2004. http://hdl.handle.net/10150/280522.

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Cyclin D1 expression is deregulated by chromosome translocation in mantle cell lymphoma and a subset of multiple myeloma. The epigenetic mechanisms involved in this long-distance gene deregulation were studied. The cyclin D1 promoter was hypomethylated and hyperacetylated in expressing cell lines and patient samples. Domains of hyperacetylated histones and hypomethylated DNA extended over 120 kilobases upstream of the cyclin D1 gene. Interestingly, hypomethylated DNA and hyperacetylated histones were also located at the cyclin D1 promoter but not upstream regions in cyclin D1 nonexpressing, no

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Powers, Tiffany M. "Expression patterns of cyclin D1, D2, and D3 in the first three cell cycles in preimplantation embryo development." Virtual Press, 2004. http://liblink.bsu.edu/uhtbin/catkey/1306857.

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Cell-cycle progression in mammalian cells is coordinated by a series of control points. The D-type cyclins are a family of key cell cycle regulators that are controlled largely by mitogens and their association with and activation of cdk 4 and 6 at the G1 phase of the cell cycle. This study seeks to first analyze cyclins D1, D2, and D3 expression patterns in preimplantation mouse embryos using in vivo studies and then analyze the effects of Dilantin on the cyclin D1 expression pattern in cultured embryos. Antibody staining against cyclin D1, D2, and D3 via indirect immunofluorescence using a Z

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Cox, Jr Ruan Rollin. "Aspirin Triggered Resolution Phase Interaction Product D1: A Novel Treatment for Hyperoxic Acute Lung Injury." Scholar Commons, 2015. http://scholarcommons.usf.edu/etd/5931.

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Acute Lung injury (ALI) and the more severe acute respiratory distress syndrome (ARDS) are respiratory maladies that present immense clinical challenges. ALI affects 200,000 individuals annually and features a 40% mortality rate. ALI can be initiated by both pathogenic and sterile insults originating locally in the lungs or systemically. While immense research has been poured into this disease in an effort to find a therapeutic strategy, the heterogeneously diffuse nature of the disease has not yielded a cure for the disease. Death from this disease is strongly attributed to reduced gas exchan

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Nai, Gisele Alborghetti [UNESP]. "O possível papel da proteína ROC1 na expressão da proteína ciclina D1 em melanomas cutâneos." Universidade Estadual Paulista (UNESP), 2009. http://hdl.handle.net/11449/104578.

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Made available in DSpace on 2014-06-11T19:33:24Z (GMT). No. of bitstreams: 0 Previous issue date: 2009-04-27Bitstream added on 2014-06-13T20:44:51Z : No. of bitstreams: 1 nai_ga_dr_botfm.pdf: 3030402 bytes, checksum: 8e4cb8d3e8bdba62388efa31559314a0 (MD5)<br>Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)<br>O aumento da expressão de ciclina D1, demonstrado em melanomas cutâneos, provavelmente está relacionado ao potencial invasivo do tumor. A diminuição da proteína ROC1, envolvida na degradação da ciclina D1, pode constituir uma alternativa para explicar o aumento desta proteí

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Oliveira, Maykon Kennedy Schulz. "Expressão de CD10, Vimentina, Ki-67 e Ciclina D1 em carcinomas espinocelulares de cabeça e pescoço : avaliação clínico-patológica /." Araraquara, 2018. http://hdl.handle.net/11449/153290.

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Orientador: Andreia Bufalino<br>Resumo: O carcinoma espinocelular (CEC) é a sexta malignidade mais comum do mundo, e na região de cabeça e pescoço representa mais de 90% das malignidades. Mesmo com os recentes avanços nos protocolos de tratamento cirúrgico, radioterápico e quimioterápico, a taxa de sobrevida de 5 anos para pacientes com carcinoma espinocelular de cabeça e pescoço (CECCP) permanece reduzida. Diversos fatores podem contribuir para esse baixo índice de sobrevida e, somado a isso, ainda não existem marcadores biológicos que possam contribuir na orientação da melhor opção terapêuti

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Budnjo, Almir. "Gene expression of MAP2K1 and Cyclin D1 in BDII rat model of Endometrial cancer." Thesis, Högskolan i Skövde, Institutionen för biovetenskap, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-12869.

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Endometrial adenocarcinoma (EAC) is the most frequently diagnosed gynecological cancer of the female genital tract in the Western world. Research studies in EC is difficult to conduct on human tumor samples due to the complex nature of tumor arousal and genetic heterogeneousness in the human population. Therefore, inbred animal models can be promising tools to use in EC research due to similar histopathology and pathogenesis as humans. Studies performed on MAP2K1 and CCND1 has shown that their altered expression play a crucial role in carcinogenesis. CCND1 has been demonstrated to have oncogen

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Salvatorelli, Lucia. "Cyclin D1 and wilms tumor transcription factor-1 (WT1): potential diagnostic and therapeutic markers in small rond blue cell tumors of childhood." Doctoral thesis, Università di Catania, 2018. http://hdl.handle.net/10761/4156.

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Wilms tumor 1 (WT1) gene, firstly cloned in 1990 in the childhood kidney cancer Wilms tumor, is a gene located on chromosome 11p13, which encodes zinc-fingers protein characterized by multiple alternative isoforms, with important regulatory functions in cell growth and development. The protein Cyclin D1 (CD1), encoded by the CCND1 gene, belongs to the highly conserved cyclin family, whose members function as regulators of CDKs (cyclin-dependent kinase) through-out the cell cycle. CD1 serves as a key sensor and integrator of extracellular signals of cells to promote progression through the G1

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Pérez, Fusté Noel. "Mecanismes de regulació de l'adhesió i la invasió cel·lulars pel complex ciclina D1-Cdk4 citoplasmàtic." Doctoral thesis, Universitat de Lleida, 2016. http://hdl.handle.net/10803/399572.

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El rol més conegut de ciclina D1 és com a regulador del cicle cel·lular i la proliferació, però diversos estudis suggereixen que ciclina D1 també interacciona amb proteïnes citoplasmàtiques involucrades en la regulació de la migració i la invasió cel·lulars. En aquest treball es mostra que la paxilina, una proteïna dels focus d'adhesió implicada en la regulació de l’adhesió i la migració, és un substrat citoplasmàtic del complex ciclina D1-Cdk4. Aquest complex fosforila una fracció de paxilina que es troba associada a la membrana cel·lular i promou l'activació de la GTPasa Rac1, induint la mig

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Holley, Sarah Louise. "Polymorphism in cyclin D1 : effects on gene function and prognosis in squamous cell carcinoma of the head and neck." Thesis, Keele University, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.275239.

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Garcia, Natália Galvão. "Avaliação da expressão de β-catenina e ciclina D1 como biomarcadores preditivos para o câncer de lábio." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/25/25150/tde-25112016-103300/.

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Um dos objetivos da pesquisa científica, atualmente, é encontrar biomarcadores que possam auxiliar na definição da probabilidade de progressão das lesões orais displásicas, e ainda sejam capazes de identificar os principais agentes moleculares envolvidos na carcinogênese de um determinado tipo de tumor. Assim, o objetivo deste estudo foi investigar a expressão de β-catenina, ciclina D1 e Ki-67 em 15 espécimes de epitélio oral normal, 45 queilites actínicas displásicas e em 30 carcinomas espinocelulares de lábio. Essa amostra foi constituída por pacientes tratados na Faculdade de Medicina

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Åkervall, Jan. "Prognostic factors in squamous cell carcinoma of the head and neck with emphasis on 11q13 rearrangments and Cyclin D1 overexpression /." Lund : Dept. of Otorhinolaryngology, Head and Neck Surgery, University Hospital of Lund, 1998. http://books.google.com/books?id=xp1rAAAAMAAJ.

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Aburad, Arlindo Tadeu Teixeira. "\"Expressão das proteínas ciclina D1, c-jun e do retinoblastoma e pesquisa do HPV em carcinomas epidermóides bucais\"." Universidade de São Paulo, 2006. http://www.teses.usp.br/teses/disponiveis/23/23141/tde-15032007-083003/.

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No Brasil, como no mundo, o carcinoma epidermóide bucal está entre os dez tipos mais comum de câncer e acomete mais de 13 mil pessoas por ano. Apesar de ser um sério problema devido a sua morbidade e mortalidade, alguns casos desta doença têm um comportamento biológico menos agressivo. A proteína ciclina D1, depois que forma complexos com as proteínas CDK4 e CDK6, tem como principal função fosforilar a proteína Retinoblastoma. Após sua fosforilação, a proteína libera um fator de transcrição, o E2F, que leva a célula à progressão da fase G1 para fase S do ciclo celular. A proteína c-jun, que fa

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Chen, Chun, Peng Li, Ye Li, Guan Yao, and Jian-Hua Xu. "Antitumor effects and mechanisms of Ganoderma extracts and spores oil." SPANDIDOS PUBL LTD, 2016. http://hdl.handle.net/10150/622362.

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Ganoderma lucidum is a popular herbal medicine used in China to promote health. Modern studies have disclosed that the active ingredients of Ganoderma can exhibit several effects, including antitumor effects and immunomodulation. The present study evaluated the antitumor effects of self-prepared Ganoderma extracts and spores oil, and investigated the possible underlying mechanisms by observing the effects of the extracts and oil on topoisomerases and the cell cycle. The results showed that Ganoderma extracts and spores oil presented dose-dependent inhibitory effects on tumor cells. The half ma

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Do, Le Duy. "Relation entre l’annexine A6 et la phospholipase D1 pendant le processus d’exocytose dans les cellules PC12." Thesis, Lyon 1, 2014. http://www.theses.fr/2014LYO10160/document.

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L'exocytose régulée, est un processus qui permet la communication entre les cellules à travers la sécrétion des hormones et des neurotransmetteurs. Dans les neurones et les cellules neuroendocrines, l'exocytose est strictement contrôlée par des signaux extracellulaires tels que le potentiel trans-membranaire et la fixation des ligands sur des récepteurs. Des progrès substantiels ont été effectués afin de comprendre le mécanisme moléculaire de l'exocytose. Les composants majeurs de la machinerie de sécrétion ont été dévoilés. Maintenant, la question qui émerge concerne le rôle de la plateforme

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Soppa, Ulf-Werner [Verfasser]. "The protein kinase DYRK1A regulates cell cycle progression, neuronal differentiation, and stability of the proteins p27Kip1, Cyclin D1 and Septin4 / Ulf-Werner Soppa." Aachen : Hochschulbibliothek der Rheinisch-Westfälischen Technischen Hochschule Aachen, 2014. http://d-nb.info/1059533812/34.

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Scott, Lena. "Plasticity in the dopamine 1 receptor system : behavior and cell biological studies /." Stockholm, 2004. http://diss.kib.ki.se/2004/91-7140-060-5/.

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Rodríguez, Ruiz Mar. "Heterómeros de receptores de dopamina D1 y de histamina H3 como potenciales dianas terapéuticas en trastornos adictivos y enfermedades neurodegenerativas." Doctoral thesis, Universitat de Barcelona, 2018. http://hdl.handle.net/10803/663444.

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Los GPCRs son proteínas de membrana versátiles capaces de ser activadas por una amplia variedad de estímulos y son responsables de la transducción de señales extracelulares de manera específica. Regulan múltiples procesos fisiológicos, por lo que constituyen el 34% de las dianas de los fármacos comercializados en la actualidad. Aun así, existe el problema de la falta de selectividad de los ligandos ortostéricos y de la gran variedad de procesos que se ven modulados por la estimulación de un mismo GPCR dependiendo de su localización o interacción con otras proteínas. Concretamente, las interacc

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Iyirhiaro, Grace O. "The Role of Cell Cycle Machinery in Ischemic Neuronal Death." Thèse, Université d'Ottawa / University of Ottawa, 2013. http://hdl.handle.net/10393/26230.

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Ischemic stroke occurs as a result of a lack or severe reduction of blood supply to the brain. Presently therapeutic interventions are limited and there is a need to develop new and efficacious stroke treatments. To this end, a great deal of research effort has been devoted to studying the potential molecular mechanisms involved in ischemic neuronal death. Correlative evidence demonstrated a paradoxical activation of the cell cycle machinery in ischemic neurons. The levels and activity of key cell cycle regulators including cyclin D1, Cdk2 and Cdk4 are upregulated following ischemic insults.

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Quiles, Lara Ignacio. "Análisis de los dominios funcionales del receptor de progesterona en líneas celulares estables de cáncer de mama." Doctoral thesis, Universitat Pompeu Fabra, 2007. http://hdl.handle.net/10803/7178.

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Esta tesis se interesa por distinguir entre los efectos directos de los receptores nucleares y aquellos mediados por las rutas de transducción de señales en la transcripción de genes en respuesta a hormona y proliferación celular. Para esto, nosotros hemos expresado establemente en una línea celular T47Dy desprovista de PR, formas variantes marcadas de la isoforma B del PR en regiones involucradas bien en la unión al DNA(PRB-DBD), en su habilidad para interaccionar con ER y activar la cascada c-Src/Erk (PRB-ERID), o la incapacidad de reclutar coactivadores. La expresión génica en respuesta a p

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