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Artykuły w czasopismach na temat „Dechallenge”

Autor: Grafiati

Data publikacji: 3 czerwca 2025

Data aktualizacji: 31 lipca 2025

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1

Stephens, Myles D. "Dechallenge Revisited." Drug Information Journal 29, no. 1 (1995): 335–38. http://dx.doi.org/10.1177/009286159502900139.

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V.Vijaya, Prasad* P.Venkata Sravan Kumar Dr R. Siddarama. "DEATH DUE TO STEVENS JOHNSON SYNDROME; A RARE CASE REPORT." Indo American Journal of Pharmaceutical Sciences 04, no. 07 (2017): 2072–76. https://doi.org/10.5281/zenodo.835176.

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Stevens Johnson’s syndrome is a life threatening drug induced hypersensitivity reaction. The drugs that cause SJS commonly are antibacterials (sulfonamides), anticonvulsants (phenytoin, phenobarbital, and carbamazepine), non-steroidal anti-inflammatory drugs (oxicam derivatives) and oxide inhibitors (allopurinol).Clinical symptoms are urticarial skin eruptions, arthralgia or arthritis, lymphadenopathy and fever.Treatment of Stevens Johnsons Syndrome includes systemic steroids, cyclosporine, intravenous immunoglobulin’s and supportive therapy.A male patient of 58 years was admitted in cardiolog

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Lefebvre, Jean, Luc Poirier, and Yves Lacourcière. "Prospective Trial on Captopril-Related Cough." Annals of Pharmacotherapy 26, no. 2 (1992): 161–64. http://dx.doi.org/10.1177/106002809202600202.

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OBJECTIVE: Quantify and characterize cough as an adverse reaction secondary to captopril. DESIGN: Cohort analytic study: six-month prospective trial including two-week, placebo, run-in period; five-month, single-blind, active treatment; and two-week, dechallenge period. SETTING: Outpatient clinic. PATIENTS: 199 previously treated or newly diagnosed untreated patients with mild to moderate hypertension. INTERVENTIONS: Captopril 50 mg/d during five months. OUTCOME MEASURES: Self-questionnaires, interviews, dechallenge, and rechallenge periods, Naranjo's algorithm. RESULTS AND CONCLUSIONS: (1) Cu

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4

Romaszko, Jerzy, Ryszard Targonski, Leszek Cichowski, and Janusz Sadowski. "Indapamide-induced hyponatremia or the syndrome of inappropriate antidiuretic hormone secretion: a case report." Open Medicine 6, no. 4 (2011): 407–10. http://dx.doi.org/10.2478/s11536-011-0027-z.

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AbstractWe report a case of an apparently well-documented indapamide-induced hyponatremia. The initial diagnosis was made on the basis of dechallenge and rechallenge performed on two occasions. Further course of the disease, which proved inconsistent with our expectations, prompted us to look for another aetiology leading to the final diagnosis of the syndrome of inappropriate antidiuretic hormone secretion (SIADH) complicated by indapamide treatment.

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Zeiner, Evmarie, Lea S. Blaser, Kai Tisljar, Dominik Heim, and Anne Taegtmeyer. "Fatale Agranulozytose nach Metamizol-Reexposition." Praxis 104, no. 3 (2015): 151–54. http://dx.doi.org/10.1024/1661-8157/a001916.

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Wir stellen den Fall eines 63-jährigen Mannes vor, der einen schweren septischen Schock mit letalem Ausgang auf Basis einer Agranulozytose entwickelte. Aufgrund des zeitlichen Zusammenhangs, der Verbesserung nach Dechallenge in der Vorgeschichte und aktuellem Rechallenge ist der Kausalzusammenhang für eine erneute Metamizol-induzierte Agranulozytose sicher. Wir diskutieren die Wichtigkeit, Patienten mit einer verdächtigten Metamizol-induzierten Agranulozytose nicht erneut zu exponieren und Patienten sowie behandelnde Ärzte lückenlos zu informieren.

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Schneider, Jenny Sarah, Matteo Montani, and Felix Stickel. "Drug-Induced Autoimmune Hepatitis following Treatment with Zoledronic Acid." Case Reports in Gastroenterology 11, no. 2 (2017): 440–45. http://dx.doi.org/10.1159/000479314.

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Adverse drug reactions are among the most frequent side effects of synthetic and complementary alternative drugs and represent the premier causes of license revocations and acute liver failure. Drug-induced liver injury can resemble literally any other genuine liver disease and usually responds well to drug dechallenge. However, in some cases autoimmune-like hepatitis can evolve, requiring short- and sometimes long-term immunosuppression. Here, we present the hitherto first case of autoimmune-like hepatitis following treatment with zoledronic acid.

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7

Hulisz, Darrell T., Jeffrey R. Welko, and Darell E. Heiselman. "Sinus Arrest Associated With Continuous‐Infusion Cimetidine." Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy 13, no. 1 (1993): 64–67. http://dx.doi.org/10.1002/j.1875-9114.1993.tb02691.x.

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The administration of intermittent intravenous infusions of cimetidine is infrequently associated with the development of bradyarrhythmias. A 40‐year‐old man with leukemia and no history of cardiac disease developed recurrent, brief episodes of apparent sinus arrest while receiving continuous‐infusion cimetidine 50 mg/hour. The arrhythmias were temporally related to cimetidine administration, disappeared after dechallenge, and did not recur during ranitidine treatment. This is the first reported case of sinus arrest associated with continuous‐infusion cimetidine.

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Tandon, Vishal R., Sheikh Hanan Ismail, and Amarjeet Singh. "Fixed drug combination (levosulpiride and rabeprazole)-induced atypical Parkinsonian’s disorders with associated anxiety and low-lying depression." Indian Journal of Pharmacology 56, no. 1 (2024): 52–54. http://dx.doi.org/10.4103/ijp.ijp_929_21.

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We hereby describe a rare case of levosulpiride-induced atypical parkinsonism presenting with sluggish movements, atypical kinetic tremors (tremors with voluntary movement), periorbital tremors, dystonia, difficulty in speech and coordination, postural imbalance, with additional features of difficulty in swallowing and drooling with associated recent onset psychiatric disturbances such as anxiety and low-lying depression. The dechallenge of levosulpiride and medications for associated anxiety and low-lying depression caused a complete remission of the disease within 2 ½ months.

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9

Carlini, Elisaldo Luiz de Araújo, and Solange Aparecida Nappo. "The pharmacovigilance of psychoactive medications in Brazil." Revista Brasileira de Psiquiatria 25, no. 4 (2003): 200–205. http://dx.doi.org/10.1590/s1516-44462003000400004.

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OBJETIVE: The present study aimed to analyze 219 notifications of suspected adverse reactions (AR) produced by psychoactive medicaments (ARPM), notified by Brazilian psychiatrists, during a 3-month period (April 1999 up to September 2001). METHOD: A notifying card for adverse reactions possibly produced by psychoactive medications was quarterly sent to all psychiatrists affiliated to the Brazilian Association of Psychiatry. Once each notification, dully filled in, was received, the possible adverse reaction was analyzed in order to verify the causality RESULTS: The psychiatrists classified as

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10

GAUJOUX-VIALA, CÉCILE, CECILIA GIAMPIETRO, THOMAS GAUJOUX, et al. "Scleritis: A Paradoxical Effect of Etanercept? Etanercept-associated Inflammatory Eye Disease." Journal of Rheumatology 39, no. 2 (2011): 233–39. http://dx.doi.org/10.3899/jrheum.110865.

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Objective.To describe 3 cases of scleritis associated with etanercept use for rheumatoid arthritis (RA) and to review the literature related to inflammatory eye diseases associated with the use of etanercept.Methods.Three cases of severe scleritis during etanercept therapy were analyzed. A systematic review of the literature in PubMed, Embase, and the Cochrane Library was performed, from 1962 to July 2010.Results.Three patients with seropositive RA developed scleritis 7–28 months after initiation of etanercept, for the first time during their long-lasting disease. In all patients the underlyin

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11

Banu, ABazila, SAppavu Alias Balamurugan, and Ponniah Thirumalaikolundusubramanian. "Detection of dechallenge in spontaneous reporting systems: A comparison of Bayes methods." Indian Journal of Pharmacology 46, no. 3 (2014): 277. http://dx.doi.org/10.4103/0253-7613.132157.

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Tumanan-Mendoza, Bernadette A., Antonio L. Dans, Lourdes Lucienne Villacin, et al. "Dechallenge and rechallenge method showed different incidences of cough among four ACE-Is." Journal of Clinical Epidemiology 60, no. 6 (2007): 547–53. http://dx.doi.org/10.1016/j.jclinepi.2006.06.017.

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13

Abtahi-Naeini, Bahareh, Tooba Momen, Rezvan Amiri, Parvin Rajabi, and Fereshte Rastegarnasab. "Metformin-Induced Generalized Bullous Fixed-Drug Eruption with a Positive Dechallenge-Rechallenge Test: A Case Report and Literature Review." Case Reports in Dermatological Medicine 2023 (March 31, 2023): 1–6. http://dx.doi.org/10.1155/2023/6353919.

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Metformin is a commonly used medication in diabetic patients. It can cause different complications including cutaneous adverse reactions. Metformin-induced fixed-drug eruption (FDE) has been reported in limited cases. Due to the popularity of metformin, clinicians need to be aware of uncommon drug reactions for proper diagnosis and treatment. Herein, we report a 43-year-old man with generalized bullous lesions with a positive dechallenge-rechallenge test diagnosed as metformin-induced generalized bullous fixed-drug eruption. Metformin dosage was stopped and lesions were treated with topical cl

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14

Chawla, Harsimran Singh, Mohammad Rafi, Sonny K. Varkey, M. Manitha Kumarie, and Ben George. "Apremilast induced intolerable dizziness: A rare unlisted adverse effect." Indian Journal of Drugs in Dermatology 9, no. 2 (2023): 80–81. https://doi.org/10.4103/ijdd.ijdd_12_23.

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Abstract Apremilast is a small-molecule biologic that has been approved by the U.S. Food and Drug Administration for the treatment of plaque psoriasis, psoriatic arthritis, and Behcet’s disease. It was approved by the European Union in 2015 for psoriatic arthritis. Apremilast is generally well tolerated, with gastrointestinal side effects and headache being the most commonly reported adverse events. We here report an unusual case of an adult male patient who developed progressive nervous system adverse effects namely dizziness and lightheadedness shorly after initiating titration doses of Apre

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15

Ursini, Francesco, Saverio Naty, Caterina Bruno, Marilena Calabria, Francesco Spagnolo, and Rosa Daniela Grembiale. "CD4+ T-cells lymphocytosis and reduction of neutrophils during treatment with adalimumab: Challenge and dechallenge study." Clinical Immunology 135, no. 3 (2010): 499–500. http://dx.doi.org/10.1016/j.clim.2010.02.004.

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Thompson, Dennis F., and Penny A. Skaehill. "Drug‐Induced Lichen Planus." Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy 14, no. 5 (1994): 561–71. http://dx.doi.org/10.1002/j.1875-9114.1994.tb02852.x.

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Lichen planus is a relatively common skin disorder of unknown etiology. A wide variety of drugs have been implicated in its cause. Using five or more cases of drug‐induced lichen planus reported in at least three separate reports with at least one case of probable cause by the scale of Naranjo et al as criteria, sufficient evidence exists that β‐blockers, methyldopa, penicillamine, quinidine, and quinine play a role in this disorder. Evidence is insufficient for angiotensin‐converting enzyme inhibitors, sulfonylurea agents, carbamazepine, gold, lithium, and a host of miscellaneous drugs. Given

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Šíma, Martin, Miroslav Pokorný, František Paďour, and Ondřej Slanař. "Terlipressin Induced Severe Hyponatremia." Prague Medical Report 117, no. 1 (2016): 68–72. http://dx.doi.org/10.14712/23362936.2016.7.

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Terlipressin is a vasopressin analogue used for its vasoconstrictor effect in the treatment of variceal bleeding. Despite its good safety profile compared to vasopressin, some adverse reactions may occur during its use – e.g. hyponatremia. We describe a case of a cirrhotic patient with active variceal bleeding treated during two separate hospitalizations with terlipressin. In both drug treatment periods, severe laboratory hyponatremia developed. After terlipressin discontinuation, mineral disbalance corrected rapidly. Positive dechallenge and rechallenge corresponding to the drug administratio

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Kusuma, Kumari.S* Rajesh .G Dr. Siddarama. R. "DRUG INDUCED DYSELECTROLYTEMIA –A CASE REPORT." Indo American Journal of Pharmaceutical Sciences 04, no. 07 (2017): 2047–50. https://doi.org/10.5281/zenodo.834968.

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Abstract: Spiranolactone and Eplerenone were belongs to the class of potassium sparing diuretics where as Torsemide belongs to the loop diuretic class, they mainly acts by blocking the function of aldosterone hormone to retain the sodium and excrete potassium. By irrational use of these drugs induced dyselectrolytemia like hyperkalemia and hyponatremia. A 55 years female patient was admitted in cardiology department with the chief complaints of drowsiness and slow response to commands by using of the diuretics (Spiranolactone , Eplerenone and Torsemide) causes the electrolytes induced hyperkal

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Harsh H. Patel, Harsha D. Makwana, and Supriya D. Malhotra. "Linezolid Induced Thrombocytopenia: A Case Report." Innovative Journal of Medical and Health Science 11, no. 05 (2021): 1702–4. http://dx.doi.org/10.15520/ijmhs.v11i05.3307.

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Linezolid (LZD) is an antimicrobial agent with a broad spectrum of activity against virtually all clinically important Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA), methicillin-resistant coagulase-negative staphylococci (MRCoNS) and vancomycin-resistant enterococci (VRE). Thrombocytopenia (TP) is a common adverse effect of Linezolid (LZD). Prolonged treatment duration, renal insufficiency, chronic liver disease, malignancy, previous vancomycin use, baseline platelet count, and lower body weight have been reported as possible risk factors for LZD-associat

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Saad Shaikh, Saad Shaikh, and Ashvi Vashi Ashvi Vashi. "Betamethasone induced Iatrogenic Cushing’s Syndrome in a patient with Systemic Lupus Erythematosus: A Case Report." International Journal of Pharmaceutical Research and Applications 10, no. 3 (2025): 1008–12. https://doi.org/10.35629/4494-100310081012.

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Background: Cushing’s syndrome (CS) is a disorder characterized by prolonged exposure to elevated glucocorticoid levels. Exogenous or iatrogenic CS is the most common form, frequently associated with long-term corticosteroid therapy, particularly in autoimmune diseases such as systemic lupus erythematosus (SLE). Case Summary: We report a case of a 72-year-old female with a history of SLE and hypertension who developed iatrogenic Cushing’s syndrome following 2–3 months of oral betamethasone therapy. She presented with progressive weight gain, moon facies, truncal obesity, and fatigue. Diagnosti

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Attardo, Silvia, Olimpia Musumeci, Daniele Velardo, and Antonio Toscano. "Statins Neuromuscular Adverse Effects." International Journal of Molecular Sciences 23, no. 15 (2022): 8364. http://dx.doi.org/10.3390/ijms23158364.

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Statins are drugs widely prescribed in high-risk patients for cerebrovascular or cardiovascular diseases and are, usually, safe and well tolerated. However, these drugs sometimes may cause neuromuscular side effects that represent about two-third of all adverse events. Muscle-related adverse events include cramps, myalgia, weakness, immune-mediated necrotizing myopathy and, more rarely, rhabdomyolysis. Moreover, they may lead to peripheral neuropathy and induce or unmask a preexisting neuromuscular junction dysfunction. A clinical follow up of patients assuming statins could reveal early side

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Zambrone, Flávio Ailton Duque, Cristiana Leslie Corrêa, and Ligia Mesquita Sampaio do Amaral. "A critical analysis of the hepatotoxicity cases described in the literature related to Herbalife (r) products." Brazilian Journal of Pharmaceutical Sciences 51, no. 4 (2015): 785–96. http://dx.doi.org/10.1590/s1984-82502015000400004.

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Abstract The aim of this study was to assess the hepatotoxicity cases described in the literature, attributed to the consumption of Herbalife(r) products, and to determine whether a causal relationship exists between the reported cases of liver injury and the use of these products. A literature search was performed on the PubMed, LILACS and PAHO databases. Seven publications reporting a total of 53 cases of hepatotoxicity linked to the use of Herbalife(r) products were retrieved. All of the studies lacked sufficient information to some degree, whether related to patients' history, concomitant

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Barry, Arden R., Jessica E. Beach, and Glen J. Pearson. "Prevention and management of statin adverse effects: A practical approach for pharmacists." Canadian Pharmacists Journal / Revue des Pharmaciens du Canada 151, no. 3 (2018): 179–88. http://dx.doi.org/10.1177/1715163518768534.

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Statin-associated adverse effects, primarily muscle-related symptoms, occur in up to approximately one-third of patients in clinical practice. Recently, a Canadian Consensus Working Group outlined 6 key principles to assess and manage patients with goal-inhibiting statin intolerance, defined as a syndrome characterized by symptoms or biomarker abnormalities that prevent the long-term use of and adherence to indicated statin therapy, which includes a trial of at least 2 statins and precludes reversible causes of statin adverse effects. These principles ensure patients are appropriately receivin

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Raschi, Emanuel, Michele Fusaroli, Milo Gatti, Paolo Caraceni, Elisabetta Poluzzi, and Fabrizio De Ponti. "Liver Injury with Nintedanib: A Pharmacovigilance–Pharmacokinetic Appraisal." Pharmaceuticals 15, no. 5 (2022): 645. http://dx.doi.org/10.3390/ph15050645.

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Drug-induced liver injury (DILI) with nintedanib has emerged as an adverse event of special interest in premarketing clinical trials. We characterized DILI with nintedanib in the real world and explored the underlying pharmacological basis. First, we assessed serious hepatic events reported to the Food and Drug Administration’s Adverse Event Reporting System by combining the disproportionality approach [reporting odds ratio (ROR) with 95% confidence interval (CI)] with individual case assessment. Demographic and clinical features were inspected (seriousness, onset, discontinuation, dechallenge

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Schlienger, Raymond G., Martin J. Keller, and Stephan Krähenbühl. "Tolterodine-Associated Acute Mixed Liver Injury." Annals of Pharmacotherapy 36, no. 5 (2002): 817–19. http://dx.doi.org/10.1345/aph.1a418.

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OBJECTIVE: To report a patient with an acute mixed liver injury associated with tolterodine therapy. CASE SUMMARY: An 81-year-old white woman with urge incontinence experienced malaise, fever, and gastrointestinal disturbances 18 days after starting tolterodine 2 mg twice daily. The patient's concurrent medications included flunitrazepam, diclofenac, and dorzolamide/timolol eye drops. Laboratory examination was consistent with the presentation of an acute mixed liver injury with increased transaminase enzymes, alkaline phosphatase, λ-glutamyltransferase, and bilirubin. Additionally, she had mi

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Adam, Jean-Philippe, Philippe Gauthier, and Nathalie Letarte. "Safe administration of docetaxel after weekly paclitaxel-induced acute pancreatitis." Journal of Oncology Pharmacy Practice 23, no. 7 (2016): 540–44. http://dx.doi.org/10.1177/1078155216660184.

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Acute pancreatitis is an inflammatory process of the pancreas that can be mild to severe. It requires biochemical or radiologic evidence to establish the diagnosis. Only few chemotherapy agents are directly linked to acute pancreatitis. In this case report, we describe a patient who developed a mild acute pancreatitis on weekly paclitaxel with a positive dechallenge and rechallenge. A 57-year-old woman with advanced ovarian cancer started chemotherapy with carboplatin (AUC 5 every three weeks) and weekly paclitaxel (80 mg/m2 on days 1, 8, and 15). On day 13 of cycle 1, the patient presented wi

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Subbaiah, Meda Venkata, Veesam Harinath Reddy, Y. Maneesha, et al. "Retrospective Analysis of Adverse Drug Reactions at South Indian Tertiary Care Teaching Hospital." Journal of Drug Delivery and Therapeutics 12, no. 2 (2022): 78–82. http://dx.doi.org/10.22270/jddt.v12i2.5383.

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Background: Adverse drug reaction (ADR) is an appreciably harmful reaction from an intervention related to the use of the medicinal product, which predicts hazard from future administration and specific treatment, or alteration of the dosage regimen, or withdrawal of the product. This study aimed to analyze ADRs retrospectively to understand their nature at the study site. Methods: Retrospective analysis of the ADRs reported over 6 months was conducted at a South Indian Tertiary Care Teaching Hospital.We analyzed Patient characteristics, Causality, Severity,Dechallenge, Rechallenge, Mana

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Kurysheva, N. I., О. А. Pererva, А. А. Ivanova, and G. А. Sharova. "A clinical case of choroidal effusion associated with the use of carbonic anhydrase inhibitors." Fyodorov journal of ophthalmic surgery, no. 1 (March 20, 2021): 63–67. http://dx.doi.org/10.25276/0235-4160-2021-1-63-67.

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Relevance. Choroidal effusion is a complication accompanying both surgical interventions and ophthalmopathies of predominantly inflammatory etiology. The release of proteins from choriocapillaries lumen and decrease of intraocular pressure relative to the pressure in the episcleral veins lead to the choroid detachment. Purpose. To analyze the causal link between choroidal effusion and topical application of carbonic anhydrase inhibitors using a clinical example. Material and methods. The paper describes a clinical case of the development of unilateral recurrent choroidal effusion 13 years afte

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Cui, Yuqi, Sayed Aliul Hasan Abdi, Jeanne Wei, and Gohar Azhar. "The Long-Term Cardiovascular Risks of Duloxetine Use in Older Adults: A Retrospective Medical Record-Based Adverse Drug Reaction Assessment." Journal of Clinical Medicine 13, no. 24 (2024): 7595. https://doi.org/10.3390/jcm13247595.

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Background: Duloxetine, a Serotonin–Norepinephrine Reuptake Inhibitor (SNRI), is frequently used to treat diabetic peripheral neuropathy, depression, and fibromyalgia. However, its long-term cardiovascular implications in older individuals remain underexplored, particularly in those with pre-existing cardiovascular diseases. This medical record assessment aimed to evaluate the potential cardiovascular risks of duloxetine use in older persons after prolonged use. Methods: We evaluated adverse drug reactions (ADRs) using six medical records from elderly individuals (aged 70–79) with cardiovascul

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Duga, Alemayehu Lelisa, Francesco Salvo, Alexander Kay, and Albert Figueras. "Safety Profile of Medicines Used for the Treatment of Drug-Resistant Tuberculosis: A Descriptive Study Based on the WHO Database (VigiBase®)." Antibiotics 12, no. 5 (2023): 811. http://dx.doi.org/10.3390/antibiotics12050811.

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Background: The introduction of new drugs that increase the usage of repurposed medicines for managing drug-resistant tuberculosis (DR-TB) comes with challenges of understanding, properly managing, and predicting adverse drug reactions (ADRs). In addition to the health consequences of ADRs for the individual, ADRs can reduce treatment adherence, thus contributing to resistance. This study aimed to describe the magnitude and characteristics of DR-TB-related ADRs through an analysis of ADRs reported to the WHO database (VigiBase) in the period from January 2018 to December 2020. Methods: A descr

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Bucșa, Camelia, Ioana Frenț, Ramona Stefan, et al. "Adverse Drug Reactions to SGLT2i Reported by Type 2 Diabetes New Users: An Active Surveillance Study." Pharmaceuticals 18, no. 6 (2025): 904. https://doi.org/10.3390/ph18060904.

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Background/Objectives: Patients’ perspectives on adverse drug reactions (ADRs) may be used to update the safety profile of a drug. We aimed to prospectively follow-up on type 2 diabetes (T2D) patients who were new users of sodium-glucose co-transporter 2 inhibitors (SGLT2i) and to characterize the patient-reported ADRs within routine practice in Romania. Methods: T2D patients from ambulatory settings were interviewed over the phone based on standardized forms, at four time-points across 12 months. We captured the patients’ history and auto-medication, as well as any ADR that implied causality

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Perez, E. A., J. A. Byrne, I. W. Hammond, et al. "Results of an analysis of cardiac function in 2,812 patients treated with lapatinib." Journal of Clinical Oncology 24, no. 18_suppl (2006): 583. http://dx.doi.org/10.1200/jco.2006.24.18_suppl.583.

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583 Background: Lapatinib is an orally bioavailable reversible, dual tyrosine kinase ErbB1 and ErbB2 inhibitor. Trastuzumab, an ErbB2 inhibitor, has been associated with cardiotoxicity. Methods: Left ventricular ejection fraction (LVEF) was monitored every 8 weeks using MUGA or echocardiogram. Cardiac risk factors including age, underlying cardiovascular disease, previous exposure to AC, trastuzumab, or mediastinal/left sided radiation (XRT) were also collected. LVEF data were evaluated for ≥ NCI CTC grade 3, or ≥ 20% decline relative to baseline (& below institutional LLN). Results: 1.3%,

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Krishnasamy, Suryashri, and Acsah Annie Paul. "Decitabine-induced Sweet syndrome." BMJ Case Reports 17, no. 12 (2024): e260106. https://doi.org/10.1136/bcr-2024-260106.

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Sweet syndrome, also known as acute febrile neutrophilic dermatosis, is a rare inflammatory skin condition associated with the sudden onset of high-grade fever, painful rashes usually on the upper body, leukocytosis and neutrophilia. Approximately 21% of patients with Sweet syndrome have a concurrent malignancy, 80% of which are linked to haematological diseases, especially myelodysplastic syndrome and acute myeloid leukaemia. This is a case report of a woman in her 50s who was recently diagnosed with acute myeloid leukaemia and was started on decitabine 20 mg/m2(40 mg). She complained of feve

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GAUJOUX-VIALA, CÉCILE, CECILIA GIAMPIETRO, THOMAS GAUJOUX, et al. "Scleritis: A Paradoxical Effect of Etanercept? Etanercept-associated Inflammatory Eye Disease." December 16, 2011. https://doi.org/10.3899/jrheum.110865.

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Objective.To describe 3 cases of scleritis associated with etanercept use for rheumatoid arthritis (RA) and to review the literature related to inflammatory eye diseases associated with the use of etanercept.Methods.Three cases of severe scleritis during etanercept therapy were analyzed. A systematic review of the literature in PubMed, Embase, and the Cochrane Library was performed, from 1962 to July 2010.Results.Three patients with seropositive RA developed scleritis 7–28 months after initiation of etanercept, for the first time during their long-lasting disease. In all patients the underlyin

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Gupta, Aditya K., Mary A. Bamimore, Robert Haber, Greg Williams, Vincent Piguet, and Mesbah Talukder. "The Role of Patient‐ and Drug‐Related Factors in Oral Minoxidil and Pericardial Effusion: Analyses of Data From the United States Food and Drug Administration Adverse Event Reporting System." Journal of Cosmetic Dermatology, December 16, 2024. https://doi.org/10.1111/jocd.16732.

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ABSTRACTBackgroundWhile oral minoxidil (OM) has been associated with pericardial effusion (PE), its etiology is presently inconclusive.AimsWe characterized patient‐ and drug‐related factors across reports from the United States Food and Drug Administration Adverse Event Reporting System (FAERS) for PE and OM.MethodsOur observation period spanned 18.5 years. Parametric and non‐parametric analyses were used; we stratified our findings according to two groups of adverse events (AEs), namely, PE and all other AEs.ResultsAcross reports of OM (n = 2747), positive dechallenge (complete resolution or

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S, Naga subrahmanyam, Indu Harini S, Swathi M, and Roshin D. "Case report: adverse drug reaction due to ciprofloxacin - a case of fixed drug eruption." International Journal of Pharmaceutics and Drug Analysis, January 15, 2025, 1–3. https://doi.org/10.47957/ijpda.v13i1.613.

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A 45-year-old female presented to the dermatology department with complaints of uterine itching and a burning sensation during micturition. Ciprofloxacin 500mg PO BD was prescribed to alleviate the symptoms. However, within two hours of initiating treatment, the patient developed red lesions on her right forearm and left hand, associated with fluid-filled lesions on an erythematous base. Ciprofloxacin was identified as the causative agent of this adverse drug reaction (ADR). Given the potential severity of ADRs associated with Ciprofloxacin, it is crucial to closely monitor patients for early

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Alberico, L. Catapano. "Reported muscle symptoms during statin treatment amongst Italian dyslipidaemic patients in the real-life setting: the PROSISA Study." March 22, 2021. https://doi.org/10.5281/zenodo.4622647.

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Abstract <strong>Aim: </strong> Statin-associated muscle symptoms (SAMS) are a major determinant of poor treatment adherence and/or discontinuation, but a definitive diagnosis of SAMS is challenging. The PROSISA study was an observational retrospective study aimed to assess the prevalence of reported SAMS in a cohort of dyslipidaemic patients. <strong>Methods: </strong> Demographic/anamnestic data, biochemical values and occurrence of SAMS were collected by 23 Italian Lipid Clinics. Adjusted logistic regression was performed to estimate odds ratio (OR) and 95% confidence intervals for associat

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Pozzi, Federico Emanuele, Lucio Tremolizzo, Carlo Ferrarese, and Ildebrando Appollonio. "Donepezil-Induced Complex Multimodal Hallucinations: Two Cases and a Review of the Literature." Case Reports in Neurology, September 19, 2022, 359–65. http://dx.doi.org/10.1159/000526159.

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Hallucinations are common in neurodegenerative dementias, being present in a significant proportion of patients. Most of the available studies show that acetylcholinesterase inhibitors may be beneficial in preventing and treating hallucinations in patients with neurodegenerative and even psychiatric disorders, even though there are reports that they might also develop as an adverse effect of such therapy. However, a clear causal relationship for the latter association was not previously established. Here we describe 2 cases of patients treated with donepezil who developed complex multimodal ha

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Saccaro, Luigi F., Natacha Perez, Othman Sentissi, and Alexandre Wullschleger. "Systematic quantification of oral paliperidone dose-dependent sialorrhea in a psychotic patient: a case report of a challenge–dechallenge–rechallenge trial." Psychiatry Research Case Reports, April 2023, 100113. http://dx.doi.org/10.1016/j.psycr.2023.100113.

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Kandra, Nagavishnu, Murali Krishna Balijepalli, Upendra Rao Uttaravelli, et al. "Anti-tubercular therapy-induced maculopapular exanthema – A case series." Journal of Laboratory Physicians, May 25, 2024, 1–4. http://dx.doi.org/10.25259/jlp_2_2024.

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Tuberculosis (TB) is the most common, treatable and curable chronic infectious disease rampant in the developing countries. Anti-TB medications may be associated with several adverse effects including cutaneous reactions. Maculopapular exanthemas (MPE) are small cutaneous reddish macules and papules. Here we present 3 tuberculosis cases, treated with antitubercular therapy (ATT) enrolled in the outpatient department of Dermatology. Chief complaints were generalized rashes with itching and redness over the body. ATT was instantly stopped. Antihistamine, corticosteroid and topical emollients wer

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Alfalah, Haifa A., and Khalid N. Nagshabandi. "Confirmation of Metformin-Induced Acute Generalized Exanthematous Pustulosis Through a Positive Dechallenge-Rechallenge Test: A Case Report and Review of Cutaneous Manifestations Associated With Metformin." Cureus, January 14, 2025. https://doi.org/10.7759/cureus.77441.

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Dugauquier, Artémise, and Sina Bidgoli. "Methylphenidate-associated Alice in Wonderland syndrome." European Journal of Ophthalmology, December 9, 2020, 112067212097888. http://dx.doi.org/10.1177/1120672120978882.

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Introduction: We describe the case of a child affected by typical symptoms of Alice in Wonderland syndrome (AIWS), related to the methylphenidate treatment he was taking for an attention deficit hyperactivity disorder (ADHD). To our knowledge, this is the first case of methylphenidate-associated AIWS. Methods: Retrospective single center observational case report. Case description: A 12-year-old boy was complaining of micropsias and macropsias. Except a disruptive ADHD treated by methylphenidate for 2 years, his medical history was banal. His symptoms coincided with a change in his treatment r

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Fusaroli, Michele, Emanuel Raschi, Valentina Giunchi, et al. "Impulse Control Disorders by Dopamine Partial Agonists: A Pharmacovigilance-Pharmacodynamic Assessment through the FDA Adverse Event Reporting System." International Journal of Neuropsychopharmacology, May 27, 2022. http://dx.doi.org/10.1093/ijnp/pyac031.

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Abstract Background The dopaminergic partial agonism of the so-called third-generation antipsychotics (TGAs: aripiprazole, brexpiprazole, cariprazine) is hypothesized to cause Impulse Control Disorders (ICDs). Relevant warnings by the Food and Drug Administration (FDA) were posted on aripiprazole (2016) and brexpiprazole (2018). Our study investigated the FDA Adverse Event Reporting System (FAERS) and the pharmacodynamic CHEMBL database to further characterize TGA-induced ICDs. Methods We downloaded and pre-processed the FAERS up to December 2020. We adapted Bradford Hill criteria to assess ea

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Gill, Rupam, Balaji O., Meena K. Kumari, Amberkar Mohan Babu V., and Karthik S. Udupa. "ZOLEDRONIC ACID: A MISCHIEVOUS SUSPECT FOR LIVER INJURY." Asian Journal of Pharmaceutical and Clinical Research, September 26, 2016, 3. http://dx.doi.org/10.22159/ajpcr.2016.v9s2.13412.

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<p>ABSTRACT<br />A 47-year-old male diagnosed as adenocarcinoma of the lung and received 8 cycles of chemotherapy comprising intravenous administration of<br />cisplatin 125 mg, pemetrexed 850 mg along with zoledronic acid 4 mg. After the completion of the 8<br /> cycle, the liver enzymes were found to be<br />markedly elevated, evincing zoledronic acid as the cause for hepatotoxicity. The case details were taken from the patient’s medical record along with<br />the biochemical test reports and radiographic images. The causal association was confirmed using

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Allemang-Trivalle, Aude, Sophie Leducq, Annabel Maruani, and Bruno Giraudeau. "Designs used in published therapeutic studies of rare superficial vascular anomalies: a systematic literature search." BMC Medical Research Methodology 23, no. 1 (2023). http://dx.doi.org/10.1186/s12874-023-02017-0.

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Abstract Background Rare superficial vascular anomalies represent a wide range of diseases. Their management is difficult given the broad spectrum and the lack of clinical trials assessing treatment efficacy. A randomized clinical trial of vascular anomalies is difficult because of the rarity of the diseases and is enhanced by the population of interest often being children. Therefore, suitable designs are needed. We conducted a methodological systematic literature search to identify designs implemented for investigating the treatment of rare superficial vascular anomalies. Methods We conducte

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Wysowski, Diane K., Marilyn Pitts, and Julie Beitz. "An analysis of reports of depression and suicide in patients with isotretinoin." November 1, 2001. https://doi.org/10.1067/mjd.2001.117730.

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Background: The Food and Drug Administration (FDA) has received reports of depression and suicide in patients treated with isotretinoin. Objective: Our purpose was to provide the number and describe the cases of depression and suicide reported to the FDA in US patients treated with isotretinoin and to consider the nature of a possible association between isotretinoin and depression. Methods: An analysis was made of reports of depression, suicidal ideation, suicide attempt, and suicide in US isotretinoin users voluntarily submitted to the manufacturer and the FDA from 1982 to May 2000 and enter

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