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Rozprawy doktorskie na temat „Dendritic cell”

Autor: Grafiati

Data publikacji: 4 czerwca 2021

Data aktualizacji: 25 lipca 2025

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1

Carnathan, Diane Gail Vilen Barbara J. "Dendritic cell regulation of B cells." Chapel Hill, N.C. : University of North Carolina at Chapel Hill, 2007. http://dc.lib.unc.edu/u?/etd,1200.

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Thesis (M.S.)--University of North Carolina at Chapel Hill, 2007.<br>Title from electronic title page (viewed Mar. 26, 2008). "... in partial fulfillment of the requirements for the degree of Master of Science in the Department of Microbiology and Immunology, School of Medicine." Discipline: Microbiology and Immunology; Department/School: Medicine.

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Liu, Hao. "Dendritic cell development directed by stromal cells." Thesis, University of York, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.516409.

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Greensmith, Julie. "The dendritic cell algorithm." Thesis, Nottingham Trent University, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.444619.

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4

Kavikondala, Sushma. "Dendritic cell and B cell interactions in systemic lupuserythematosus." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2007. http://hub.hku.hk/bib/B39793710.

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5

Kavikondala, Sushma. "Dendritic cell and B cell interactions in systemic lupus erythematosus." View the Table of Contents & Abstract, 2007. http://sunzi.lib.hku.hk/hkuto/record/B39711523.

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Rigby, Rachael Jane. "Intestinal dendritic cells : characterisation of the colonic dendritic cell population and identification of potential precursors." Thesis, Imperial College London, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.407134.

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7

Javorovic, Miran. "T-Cell Stimulation by Melanoma RNA-Pulsed Dendritic Cells." Diss., lmu, 2004. http://nbn-resolving.de/urn:nbn:de:bvb:19-30569.

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8

Pérez, Zsolt Daniel. "New therapeutic strategies targeting dendritic cell-mediated dissemination of enveloped viruses." Doctoral thesis, Universitat Autònoma de Barcelona, 2020. http://hdl.handle.net/10803/669547.

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Les cèl·lules dendrítiques (DCs) són clau en la inducció de respostes immunitàries adaptatives gràcies a la seva capacitat de capturar, processar i presentar antígens derivats de patògens als limfòcits T. Tanmateix, aquestes cèl·lules podrien contribuir a la disseminació inicial del VIH-1 a través de la captura i transmissió viral a les cèl·lules T CD4+ diana, un procés conegut com a trans-infecció. Aquest mecanisme es basa en l’expressió del receptor Siglec-1 (CD169), que reconeix gangliòsids sialilats a la membrana viral. Els nivells de Siglec-1 augmenten en DCs estimulades amb interferó-alf

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9

Sarris, Milka. "Dynamics of helper T cell and regulatory T cell interactions with dendritic cells." Thesis, University of Cambridge, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.611896.

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10

Mahmood, Sajid. "Diverse regulation of natural killer cell functions by dendritic cells." Public Library of Science, 2012. http://hdl.handle.net/1993/23963.

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Natural killer (NK) cells are innate lymphocytes with inherent ability to eliminate infected cells and produce several cytokines/chemokines. They express surface receptors to sense environment and interact with other immune cells including the Dendritic cells (DC). Reciprocally, DCs are also shown to activate NK-cells. NK/DC cross-talk is well-documented, yet the molecular interactions and the diverse NK-cell activities regulated by DC remain unclear. Several target proteins such as MHC-1, Qa-1 mediate NK-cell target recognition. One such antigen, Ocil/Clr-b functions as a cognate ligand o

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11

Talay, Oezcan. "Efficient dendritic cell maturation and initiation of a strong T cell immune response requires B7-H1-mediated dendritic cell 'conditioning' during interaction with T cells." [S.l. : s.n.], 2008. http://nbn-resolving.de/urn:nbn:de:bsz:16-opus-89195.

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12

Lu, Tangying (Lily). "Cannabinoids suppress dendritic cell-induced T helper cell polarization." [Tampa, Fla] : University of South Florida, 2006. http://purl.fcla.edu/usf/dc/et/SFE0001790.

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13

Chagnon, Fanny. "A dendritic cell vaccine for murine renal cell carcinoma." Thesis, McGill University, 2003. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=19400.

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Renal Cell Carcinoma (RCC) has a very high rate of mortality since it does not respond to conventional therapies such as chemotherapy and radiation therapy. Furthermore, in the majority of cases, metastases are already present at the time of diagnosis. The objective of our study is to develop a noval treatment for RCC, using a dendritic cell (DC) vaccine. An animal model of RCC, RENCA, was used to develop the vaccine.

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14

SPREAFICO, ROBERTO. "Mechanisms of dendritic cell-mediated natural killer cell activation." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2010. http://hdl.handle.net/10281/10317.

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The cross-talk between DC and NK cells is relevant for immune responses to infectious agents and tumors. However, the molecular basis of such interaction was largely unknown. Here we defined the nature of the signals involved in DC-mediated NK cell activation, focusing on LPS stimulation, thereby mimicking the context of bacterial infections. NK cells were not able to directly sense LPS, but required TLR4-equipped accessory cells. We demonstrated that DC produce IL-2, IL-18 and IFN-β in response to LPS, and this is the minimal set of cytokines necessary and sufficient to activate NK cells in

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15

Wurzenberger, Cornelia. "Dendritic cell vaccines in tumor immunotherapy." Diss., lmu, 2009. http://nbn-resolving.de/urn:nbn:de:bvb:19-95530.

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16

Suri, Rakesh Mark. "Dendritic cell maturation, migration and function." Thesis, University of Oxford, 1998. https://ora.ox.ac.uk/objects/uuid:47d2be37-0508-47d6-8b97-a3cf8e39f9f6.

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Dendritic cells (DC) have a fundamental role in priming naive T-cell responses and a suspected importance in the regulation of central and peripheral tolerance. Before DC can be responsibly used in human clinical trials, the generation of both immature and mature subsets must be standardised and their in vivo migratory and functional characteristics explored. The generation of human blood monocyte-derived DC in either fetal calf serum (PCS) or autologous plasma (HP) were compared. Phenotypic and functional assays demonstrated that DC derived from either system were similarly immature and under

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17

Groot, Fedde. "Dendritic cell-mediated hiv-1 transmission." [S.l. : Amsterdam : s.n.] ; Universiteit van Amsterdam [Host], 2006. http://dare.uva.nl/document/36281.

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18

Morel, Anne-Sophie. "Manipulation of human dendritic cell function." Thesis, Imperial College London, 1999. http://hdl.handle.net/10044/1/11840.

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19

Netravali, Ilka Arun. "Elucidation of plasmacytoid dendritic cell development." Thesis, Harvard University, 2014. http://dissertations.umi.com/gsas.harvard:11311.

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Most currently defined hematopoietic progenitor pools are heterogeneous, contributing to uncertainty regarding the development of certain blood cells. The origins of plasmacytoid dendritic cells, for instance, have long been controversial and progenitors exclusively committed to this lineage have never been described. We show here that the fate of hematopoietic progenitors is determined in part by their surface levels of 9-O-acetyl sialic acid. Pro-plasmacytoid dendritic cells were identified as lineage negative 9-O-acetyl sialic acid low progenitors that lack myeloid and lymphoid potential

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20

Whelan, Kathryn Theresa. "Dendritic cell function in HIV disease." Thesis, University of Oxford, 2003. http://ora.ox.ac.uk/objects/uuid:15b65f1c-4d92-48ec-bcab-aecc92dc674c.

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Human immunodeficiency virus (HIV) infection is a worldwide epidemic where infected individuals usually develop acquired immunodeficiency syndrome (AIDS). HIV is primarily spread by sexual transmission across mucosal tissue where dendritic cells (DC) reside. DC regulate immune responses through their unique ability to capture antigen, migrate to lymphoid tissue, and activate naive T cells. In this Thesis, we have investigated whether HIV influences the migration of DC, thereby influencing their capacity to regulate immune function and facilitate transport of HIV to T cell rich lymphoid tissue.

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21

Meltzer, Ulrike Anne. "Dendritic cell maturation and antigen presentation." Thesis, University College London (University of London), 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.407647.

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22

Uronen-Hansson, Heli Anneli. "Dendritic cell interactions with neisseria meningitidis." Thesis, University College London (University of London), 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.405680.

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23

Kim, Jong-won. "Signalling initiation by blood dendritic cell antigen 2, a novel immunoglobulin receptor on plasmacytoid dendritic cells." Thesis, Imperial College London, 2018. http://hdl.handle.net/10044/1/63862.

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The focus of this project is a human-specific C-type lectin with potential roles in cell signalling: blood dendritic cell antigen 2 (BDCA-2). BDCA-2, a plasmacytoid dendritic cell-specific molecular marker, has been evaluated as a therapeutic target against auto-immune disorders, because antibodies to BDCA-2 inhibit the production of type I interferon. Accordingly, key goals of the project were to identify endogenous ligands for BDCA-2, to characterise the mechanism of ligand binding and ultimately to determine how ligands stimulate signalling pathways. A combination of BDCA-2 affinity chromat

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24

Smits, Hermelijn Hélène. "Instruction of effector T cell programs by flexible dendritic cells." [S.l. : Amsterdam : s.n.] ; Universiteit van Amsterdam [Host], 2003. http://dare.uva.nl/document/86946.

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25

Drakesmith, Alexander Hal. "Antigen processing and T cell priming by mouse dendritic cells." Thesis, University College London (University of London), 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.300533.

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26

Stuart, Lynda Maria. "Cell death, dendritic cells and downregulation of the immune response." Thesis, University of Edinburgh, 2003. http://hdl.handle.net/1842/23214.

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Apoptotic cells are an important source of many autoantigens and the realization that dendritic cells (DCs), the main antigen presenting cell of the adaptive immune system, not only internalise such drying cells but present antigen derived from them had important implications for our understanding of autoimmunity, tumour immunology and anti-viral responses. The aim of this thesis was to explore the likely consequences of clearance of cells dying by constitutive apoptosis by myeloid phagocytes, with particular emphasis on the mechanism and outcome of DC clearance and the implications for autoim

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27

Eaton, Laura. "Skin dendritic cells : activation, maturation and migration." Thesis, University of Manchester, 2012. https://www.research.manchester.ac.uk/portal/en/theses/skin-dendritic-cells-activation-maturation-and-migration(0831ed5e-c580-406c-a404-4b1eb59b040d).html.

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Langerhans’ cells (LC) are the dendritic cells (DC) of the epidermis and, as sentinels of the immune system, act as a bridge between the innate and adaptive immune responses. When LC, and other DC, recognise an antigen or pathogen they mature and are stimulated to migrate to the lymph nodes, where they orchestrate immune responses. Pathogen derived toll-like receptor (TLR) ligands, and chemical allergens, are recognised as being potentially harmful and stimulate LC to mobilise and mature. Cytokine signals, including tumour necrosis factor (TNF)-α, interleukin (IL)-1β, and IL-18, all induce LC

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28

Thompson, Angus Gordon. "Dendritic cell NFkB function in T cell activation and autoimmunity /." [St. Lucia, Qld.], 2004. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe18273.pdf.

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29

Schnorfeil, Frauke Marie. "MicroRNAs regulate Dendritic Cell Development and Function." Diss., lmu, 2011. http://nbn-resolving.de/urn:nbn:de:bvb:19-137930.

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30

Naik, Shalin Hemant. "Distinct precursors of the dendritic cell subtypes /." Connect to thesis, 2006. http://eprints.unimelb.edu.au/archive/00001885.

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31

Burns, Siobhan Oisn. "Dendritic cell defects in Wiskott-Aldrich syndrome." Thesis, University College London (University of London), 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.252178.

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32

Bruckner, Markus [Verfasser]. "Modulation of Dendritic Cell Behaviour / Markus Bruckner." Konstanz : Bibliothek der Universität Konstanz, 2011. http://d-nb.info/1041832877/34.

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33

Che, Karlhans Fru. "Immunomodulatory Effects of Human ImmunodeficiencyVirus (HIV-1) on Dendritic Cell and T cell Responses : Studies of HIV-1 effects on Dendritic cell functionality reflected in primed T cells." Doctoral thesis, Linköpings universitet, Molekylär virologi, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-71279.

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The human immunodeficiency virus (HIV)-1 is the causative agent of acquired immune deficiency syndrome (AIDS) worldwide. Till date there are no vaccines or cure for this infection as the virus has adapted myriad ways to remain persistent in the host where it causes severe damage to the immune system. Both humoral and cellular immune responses are mounted against HIV-1 during the initial phase of infection but fail to control viral replication as these responses are severely depleted during disease progression. Of great importance in HIV-1 research today is the in depth understanding of the typ

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Raïch, Regué Dàlia. "Generation of Tolerogenic Dendritic Cells for Cell Therapy in Multiple Sclerosis." Doctoral thesis, Universitat Autònoma de Barcelona, 2012. http://hdl.handle.net/10803/96710.

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L’esclerosi múltiple (EM) és considerada una malaltia autoimmune crònica que afecta el sistema nerviós central. Els tractaments actuals pels pacients amb EM remitent-recurrent (EM-RR) redueixen la freqüència dels brots i l’activitat inflamatòria general, però el seu efecte en la progressió de la malaltia encara no està clar. Per això és necessari desenvolupar noves aproximacions terapèutiques més específiques per tal de modificar el curs de la malaltia. En aquest sentit, una estratègia terapèutica interessant és la inhibició o supressió específica de les cèl·lules T autoreactives amb la finali

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35

Barroso, Herrera Osquel Miguel. "Manipulation of antigen-specific T cell responses by modified dendritic cells." Thesis, Imperial College London, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.405941.

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Worsley, Alan G. F. "T-cell polarisation by dendritic cells : a role for Notch ligands?" Thesis, University of Edinburgh, 2009. http://hdl.handle.net/1842/3281.

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The intention of the work described in this thesis was to identify whether the Notch signalling pathway is utilized by antigen presenting cells in order to influence CD4+ adaptive immune responses. The notion that Notch proteins may be involved in polarising CD4+ T cells is relatively recent and most of the work that had been done in this area so far has concentrated on the consequences of Notch signalling within T cells. In contrast, the work that I have done has focussed on Notch ligand expression by antigen presenting cells and addresses the question whether Notch signalling is a redundant,

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37

Williams, Charlotte Anne. "The immunoregulatory role of dendritic cells in response to cell deaths." Thesis, University of the West of England, Bristol, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.444498.

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38

Hu, Yang. "Regulation of dendritic cell and monocyte migration by interferons /." Access full-text from WCMC:, 2006. http://proquest.umi.com/pqdweb?did=1296095631&sid=1&Fmt=2&clientId=8424&RQT=309&VName=PQD.

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Sampangi, Sandeep. "Autologous human kidney proximal tubule epithelial cells (PTEC) modulate dendritic cell (DC), T cell and B cell responses." Thesis, Queensland University of Technology, 2015. https://eprints.qut.edu.au/82033/1/Sandeep_Sampangi_Thesis.pdf.

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This is a comprehensive study of human kidney proximal tubular epithelial cells (PTEC) which are known to respond to and mediate the pathological process of a range of kidney diseases. It identifies various molecules expressed by PTEC and how these molecules participate in down-regulating the inflammatory process, thereby highlighting the clinical potential of these molecules to treat various kidney diseases. In the disease state, PTEC gain the ability to regulate the immune cell responses present within the interstitium. This down-regulation is a complex interaction of contact dependent/indep

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Kalogeropoulos, Michail. "Novel mechanisms of dendritic cell regulation by leukocyte immunoglobulin-like receptor B1." Thesis, University of Aberdeen, 2014. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=210082.

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Dendritic cells play an essential role in activating immune responses upon recognition of pathogens. This results in maturation and migration to the lymph nodes, where T cells are stimulated by upregulated antigen presentation, co-stimulation and cytokine secretion. DCs are also considered important in inhibiting inappropriate immune responses against self-peptides which could lead to the development of autoimmunity. This has been attributed to DCs that demonstrate inhibited co-stimulation and cytokine secretion. It has been previously shown that the continuous ligation of an immunomodulatory

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41

Mohib, Kanishka. "Embryonic Stem Cell Extracts Possess Immune Modulatory Properties That Prevent Dendritic Cell Maturation and T Cell Activation." Thèse, Université d'Ottawa / University of Ottawa, 2012. http://hdl.handle.net/10393/22794.

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Embryonic stem cells (ESC) possess immune privileged properties and have the capacity to modulate immune activation. ESCs can persist across allogeneic immunological barriers, prevent lymphocyte proliferation in mixed lymphocyte reaction (MLR) assays and can promote graft acceptance. However, clinical application of live ESC to treat immunological disorders is not feasible as live ESC can form teratoma in-vivo. In order to harness these properties of ESCs without adverse risk to patients, we hypothesized that ESC derived extracts may retain immune modulatory properties of whole cells and there

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42

Goddard, Ruth Victoria. "Generation of in vitro B-cell chronic lymphocytic leukaemia-specific T cell responses using dendritic cells." Thesis, University of Plymouth, 2002. http://hdl.handle.net/10026.1/2695.

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Immunotherapy using dendritic cells has shown encouraging results in both haematological and non-haematological malignancies. In this study, monocyte-derived dendritic cells from patients with B-cell Chronic Lymphocytic Leukaemia were generated by culture in Interleukin-4 and Granulocyte Macrophage-Colony Stimulating Factor. Lysate-pulsed autologous dendritic cells were used as antigen presenting cells in co-culture with autologous B-cell Chronic Lymphocytic Leukaemia T-cells. B-cell Chronic Lymphocytic Leukaemia T-cells stimulated with B-cell Chronic Lymphocytic Leukaemia lysate-pulsed autolo

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Kanazawa, Nobuo. "Fractalkine and macrophage-derived chemokine : T cell attracting chemokines expressed in T cell area dendritic cells." Kyoto University, 2000. http://hdl.handle.net/2433/180886.

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Hu, Yaling. "Fucoidin enhances dendritic cell-mediated T-cell cytotoxicity against NY-ESO-1 expressing human cancer cells /." View abstract or full-text, 2008. http://library.ust.hk/cgi/db/thesis.pl?BIOL%202008%20HU.

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45

Valentin-Torres, Alice M. "Bidirectional Natural Killer Cell and Dendritic Cell Interactions in HIV-1 Pathogenesis." Case Western Reserve University School of Graduate Studies / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=case1346268879.

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Cabezón, Cabello Raquel. "Tolerogenic dendritic cell-based immunotherapy in Crohn’s disease." Doctoral thesis, Universitat de Barcelona, 2015. http://hdl.handle.net/10803/310604.

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The quality of life of a significant proportion of IBD patients is poor as a result of persistent disease activity and repeated surgery, among others. Current treatments for Crohn’s disease are not able to neither prevent this serious impact nor improve the long term prognosis of a significant proportion of patients. Therefore, new therapeutic approaches are needed in order to modify the immune response of these patients. We hypothesize that administration of ex-vivo generated autologous tol-DCs to Crohn’s disease patients may arrest Th1 lymphocyte proliferation and therefore may restore sp

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Milne, Paul. "Dendritic cell development in haematological malignancies and neoplasia." Thesis, University of Newcastle upon Tyne, 2015. http://hdl.handle.net/10443/3015.

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Dendritic cells (DC) play a major role in the detection of antigens, initiation of immunity and induction and regulation of tolerance. DCs are Bone Marrow (BM) derived and their development may be influenced by haematological malignancy in several ways. Firstly, myelodysplastic, myeloproliferative or leukaemic transformation of bone marrow progenitors may involve DC precursors directly, when they become part of a malignant clone, or indirectly when neoplastic expansion of other lineages compromises the development of DCs. Secondly, neoplasia of the dendritic cell lineage itself may occur in a

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48

Burke, Fiona. "Characterisation of dendritic cell subsets and their interactions." Thesis, Imperial College London, 2004. http://hdl.handle.net/10044/1/11955.

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Adikari, Sanjaya Bandara. "Cytokine-modulated dendritic cell immunotherapy in autoimmune diseases /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-149-0/.

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Stamataki, Zacharenia. "Identification and characterisation of folllicular dendritic cell subsets." Thesis, Imperial College London, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.417698.

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