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Artykuły w czasopismach na temat „Dendritic cell”

Autor: Grafiati

Data publikacji: 4 czerwca 2021

Data aktualizacji: 25 lipca 2025

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1

Christie, J. M., and G. L. Westbrook. "Regulation of Backpropagating Action Potentials in Mitral Cell Lateral Dendrites by A-Type Potassium Currents." Journal of Neurophysiology 89, no. 5 (2003): 2466–72. http://dx.doi.org/10.1152/jn.00997.2002.

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Dendrodendritic synapses, distributed along mitral cell lateral dendrites, provide powerful and extensive inhibition in the olfactory bulb. Activation of inhibition depends on effective penetration of action potentials into dendrites. Although action potentials backpropagate with remarkable fidelity in apical dendrites, this issue is controversial for lateral dendrites. We used paired somatic and dendritic recordings to measure action potentials in proximal dendritic segments (0–200 μm from soma) and action potential-generated calcium transients to monitor activity in distal dendritic segments

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Ligon, Cheryl, Eunju Seong, Ethan J. Schroeder та ін. "δ-Catenin engages the autophagy pathway to sculpt the developing dendritic arbor". Journal of Biological Chemistry 295, № 32 (2020): 10988–1001. http://dx.doi.org/10.1074/jbc.ra120.013058.

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The development of the dendritic arbor in pyramidal neurons is critical for neural circuit function. Here, we uncovered a pathway in which δ-catenin, a component of the cadherin–catenin cell adhesion complex, promotes coordination of growth among individual dendrites and engages the autophagy mechanism to sculpt the developing dendritic arbor. Using a rat primary neuron model, time-lapse imaging, immunohistochemistry, and confocal microscopy, we found that apical and basolateral dendrites are coordinately sculpted during development. Loss or knockdown of δ-catenin uncoupled this coordination,

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3

Chen, Wei R., Gongyu Y. Shen, Gordon M. Shepherd, Michael L. Hines, and Jens Midtgaard. "Multiple Modes of Action Potential Initiation and Propagation in Mitral Cell Primary Dendrite." Journal of Neurophysiology 88, no. 5 (2002): 2755–64. http://dx.doi.org/10.1152/jn.00057.2002.

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The mitral cell primary dendrite plays an important role in transmitting distal olfactory nerve input from olfactory glomerulus to the soma-axon initial segment. To understand how dendritic active properties are involved in this transmission, we have combined dual soma and dendritic patch recordings with computational modeling to analyze action-potential initiation and propagation in the primary dendrite. In response to depolarizing current injection or distal olfactory nerve input, fast Na+ action potentials were recorded along the entire length of the primary dendritic trunk. With weak-to-mo

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4

Kalb, R. G. "Regulation of motor neuron dendrite growth by NMDA receptor activation." Development 120, no. 11 (1994): 3063–71. http://dx.doi.org/10.1242/dev.120.11.3063.

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Spinal motor neurons undergo great changes in morphology, electrophysiology and molecular composition during development. Some of this maturation occurs postnatally when limbs are employed for locomotion, suggesting that neuronal activity may influence motor neuron development. To identify features of motor neurons that might be regulated by activity we first examined the structural development of the rat motor neuron cell body and dendritic tree labeled with cholera toxin-conjugated horseradish peroxidase. The motor neuron cell body and dendrites in the radial and rostrocaudal axes grew progr

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Fujishima, Kazuto, Junko Kurisu, Midori Yamada та Mineko Kengaku. "βIII spectrin controls the planarity of Purkinje cell dendrites by modulating perpendicular axon-dendrite interactions". Development 147, № 24 (2020): dev194530. http://dx.doi.org/10.1242/dev.194530.

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ABSTRACTThe mechanism underlying the geometrical patterning of axon and dendrite wiring remains elusive, despite its crucial importance in the formation of functional neural circuits. The cerebellar Purkinje cell (PC) arborizes a typical planar dendrite, which forms an orthogonal network with granule cell (GC) axons. By using electrospun nanofiber substrates, we reproduce the perpendicular contacts between PC dendrites and GC axons in culture. In the model system, PC dendrites show a preference to grow perpendicularly to aligned GC axons, which presumably contribute to the planar dendrite arbo

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6

Grueber, Wesley B., Lily Y. Jan, and Yuh Nung Jan. "Tiling of the Drosophila epidermis by multidendritic sensory neurons." Development 129, no. 12 (2002): 2867–78. http://dx.doi.org/10.1242/dev.129.12.2867.

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Insect dendritic arborization (da) neurons provide an opportunity to examine how diverse dendrite morphologies and dendritic territories are established during development. We have examined the morphologies of Drosophila da neurons by using the MARCM (mosaic analysis with a repressible cell marker) system. We show that each of the 15 neurons per abdominal hemisegment spread dendrites to characteristic regions of the epidermis. We place these neurons into four distinct morphological classes distinguished primarily by their dendrite branching complexities. Some class assignments correlate with k

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7

Nithianandam, Vanitha, and Cheng-Ting Chien. "Actin blobs prefigure dendrite branching sites." Journal of Cell Biology 217, no. 10 (2018): 3731–46. http://dx.doi.org/10.1083/jcb.201711136.

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The actin cytoskeleton provides structural stability and adaptability to the cell. Neuronal dendrites frequently undergo morphological changes by emanating, elongating, and withdrawing branches. However, the knowledge about actin dynamics in dendrites during these processes is limited. By performing in vivo imaging of F-actin markers, we found that F-actin was highly dynamic and heterogeneously distributed in dendritic shafts with enrichment at terminal dendrites. A dynamic F-actin population that we named actin blobs propagated bidirectionally at an average velocity of 1 µm/min. Interestingly

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8

Sharp, D. J., W. Yu, and P. W. Baas. "Transport of dendritic microtubules establishes their nonuniform polarity orientation." Journal of Cell Biology 130, no. 1 (1995): 93–103. http://dx.doi.org/10.1083/jcb.130.1.93.

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The immature processes that give rise to both axons and dendrites contain microtubules (MTs) that are uniformly oriented with their plus-ends distal to the cell body, and this pattern is preserved in the developing axon. In contrast, developing dendrites gradually acquire nonuniform MT polarity orientation due to the addition of a subpopulation of oppositely oriented MTs (Baas, P. W., M. M. Black, and G. A. Banker. 1989. J. Cell Biol. 109:3085-3094). In theory, these minus-end-distal MTs could be locally nucleated and assembled within the dendrite itself, or could be transported into the dendr

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9

Golding, Nace L., William L. Kath, and Nelson Spruston. "Dichotomy of Action-Potential Backpropagation in CA1 Pyramidal Neuron Dendrites." Journal of Neurophysiology 86, no. 6 (2001): 2998–3010. http://dx.doi.org/10.1152/jn.2001.86.6.2998.

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In hippocampal CA1 pyramidal neurons, action potentials are typically initiated in the axon and backpropagate into the dendrites, shaping the integration of synaptic activity and influencing the induction of synaptic plasticity. Despite previous reports describing action-potential propagation in the proximal apical dendrites, the extent to which action potentials invade the distal dendrites of CA1 pyramidal neurons remains controversial. Using paired somatic and dendritic whole cell recordings, we find that in the dendrites proximal to 280 μm from the soma, single backpropagating action potent

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10

Lin, Chin-Hsien, Hsun Li, Yi-Nan Lee, Ying-Ju Cheng, Ruey-Meei Wu, and Cheng-Ting Chien. "Lrrk regulates the dynamic profile of dendritic Golgi outposts through the golgin Lava lamp." Journal of Cell Biology 210, no. 3 (2015): 471–83. http://dx.doi.org/10.1083/jcb.201411033.

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Constructing the dendritic arbor of neurons requires dynamic movements of Golgi outposts (GOPs), the prominent component in the dendritic secretory pathway. GOPs move toward dendritic ends (anterograde) or cell bodies (retrograde), whereas most of them remain stationary. Here, we show that Leucine-rich repeat kinase (Lrrk), the Drosophila melanogaster homologue of Parkinson’s disease–associated Lrrk2, regulates GOP dynamics in dendrites. Lrrk localized at stationary GOPs in dendrites and suppressed GOP movement. In Lrrk loss-of-function mutants, anterograde movement of GOPs was enhanced, where

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11

Mitchell, Josephine W., Ipek Midillioglu, Ethan Schauer, Bei Wang, Chun Han, and Jill Wildonger. "Coordination of Pickpocket ion channel delivery and dendrite growth in Drosophila sensory neurons." PLOS Genetics 19, no. 11 (2023): e1011025. http://dx.doi.org/10.1371/journal.pgen.1011025.

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Sensory neurons enable an organism to perceive external stimuli, which is essential for survival. The sensory capacity of a neuron depends on the elaboration of its dendritic arbor and the localization of sensory ion channels to the dendritic membrane. However, it is not well understood when and how ion channels localize to growing sensory dendrites and whether their delivery is coordinated with growth of the dendritic arbor. We investigated the localization of the DEG/ENaC/ASIC ion channel Pickpocket (Ppk) in the peripheral sensory neurons of developing fruit flies. We used CRISPR-Cas9 genome

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12

Schutter, Erik De. "Dendritic Voltage and Calcium-Gated Channels Amplify the Variability of Postsynaptic Responses in a Purkinje Cell Model." Journal of Neurophysiology 80, no. 2 (1998): 504–19. http://dx.doi.org/10.1152/jn.1998.80.2.504.

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De Schutter, Erik. Dendritic voltage and calcium-gated channels amplify the variability of postsynaptic responses in a Purkinje cell model. J. Neurophysiol. 80: 504–519, 1998. The dendrites of most neurons express several types of voltage and Ca2+-gated channels. These ionic channels can be activated by subthreshold synaptic input, but the functional role of such activations in vivo is unclear. The interaction between dendritic channels and synaptic background input as it occurs in vivo was studied in a realistic computer model of a cerebellar Purkinje cell. It previously was shown using this

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13

A, Bajaji. "Adjunctive and Transformed Immunity: Histiocytic & Dendritic Cell Neoplasm." Gastroenterology & Hepatology International Journal 3, no. 1 (2022): 1–10. http://dx.doi.org/10.23880/ghij-16000139.

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Exceptional malignancies of the lymph nodes or soft tissue comprising of < 1% of the tumour incidence are the Histiocytic and Dendritic cell neoplasm. A definitive appearance/biology/ Hematology/ histopathology / exclusive therapeutic options describe the condition. Morphology and Immune reactive appraisal may be mandated to distinguish the neoplasm. Preface: Histiocytic and Dendritic neoplasms are infrequent disorders which incriminate the accessory immune system or mesenchymal cells. Subject to the origin of the neoplasm, from the bone marrow precursors or the mesenchye, the lesions may b

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14

Alizzi, Rebecca A., Derek Xu, Conrad M. Tenenbaum, Wei Wang, and Elizabeth R. Gavis. "The ELAV/Hu protein Found in neurons regulates cytoskeletal and ECM adhesion inputs for space-filling dendrite growth." PLOS Genetics 16, no. 12 (2020): e1009235. http://dx.doi.org/10.1371/journal.pgen.1009235.

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Dendritic arbor morphology influences how neurons receive and integrate extracellular signals. We show that the ELAV/Hu family RNA-binding protein Found in neurons (Fne) is required for space-filling dendrite growth to generate highly branched arbors of Drosophila larval class IV dendritic arborization neurons. Dendrites of fne mutant neurons are shorter and more dynamic than in wild-type, leading to decreased arbor coverage. These defects result from both a decrease in stable microtubules and loss of dendrite-substrate interactions within the arbor. Identification of transcripts encoding cyto

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15

Feng, Chengye, Pankajam Thyagarajan, Matthew Shorey, et al. "Patronin-mediated minus end growth is required for dendritic microtubule polarity." Journal of Cell Biology 218, no. 7 (2019): 2309–28. http://dx.doi.org/10.1083/jcb.201810155.

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Microtubule minus ends are thought to be stable in cells. Surprisingly, in Drosophila and zebrafish neurons, we observed persistent minus end growth, with runs lasting over 10 min. In Drosophila, extended minus end growth depended on Patronin, and Patronin reduction disrupted dendritic minus-end-out polarity. In fly dendrites, microtubule nucleation sites localize at dendrite branch points. Therefore, we hypothesized minus end growth might be particularly important beyond branch points. Distal dendrites have mixed polarity, and reduction of Patronin lowered the number of minus-end-out microtub

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16

Kloosterman, Fabian, Pascal Peloquin, and L. Stan Leung. "Apical and Basal Orthodromic Population Spikes in Hippocampal CA1 In Vivo Show Different Origins and Patterns of Propagation." Journal of Neurophysiology 86, no. 5 (2001): 2435–44. http://dx.doi.org/10.1152/jn.2001.86.5.2435.

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There is controversy concerning whether orthodromic action potentials originate from the apical or basal dendrites of CA1 pyramidal cells in vivo. The participation of the dendrites in the initialization and propagation of population spikes in CA1 of urethan-anesthetized rats in vivo was studied using simultaneously recorded field potentials and current source density (CSD) analysis. CSD analysis revealed that the antidromic population spike, evoked by stimulation of the alveus, invaded in succession, the axon initial segment (stratum oriens), cell body and ∼200 μm of the proximal apical dendr

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17

Fernandez, Fernando R., W. Hamish Mehaffey, and Ray W. Turner. "Dendritic Na+ Current Inactivation Can Increase Cell Excitability By Delaying a Somatic Depolarizing Afterpotential." Journal of Neurophysiology 94, no. 6 (2005): 3836–48. http://dx.doi.org/10.1152/jn.00653.2005.

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Many central neurons support active dendritic spike backpropagation mediated by voltage-gated currents. Active spikes in dendrites have been shown capable of providing feedback to the soma to influence somatic excitability and firing dynamics through a depolarizing afterpotential (DAP). In pyramidal cells of the electrosensory lobe of weakly electric fish, Na+ spikes in dendrites undergo a frequency-dependent broadening that enhances the DAP to increase somatic firing frequency. We use a combination of dynamical analysis and electrophysiological recordings to demonstrate that spike broadening

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18

Çelenk, Fatih. "Follicular dendritic cell sarcoma of the palatine tonsil." Praxis of Otorhinolaryngology 1, no. 2 (2013): 81–84. http://dx.doi.org/10.5606/kbbu.2013.36844.

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19

Zagha, Edward, Satoshi Manita, William N. Ross, and Bernardo Rudy. "Dendritic Kv3.3 Potassium Channels in Cerebellar Purkinje Cells Regulate Generation and Spatial Dynamics of Dendritic Ca2+ Spikes." Journal of Neurophysiology 103, no. 6 (2010): 3516–25. http://dx.doi.org/10.1152/jn.00982.2009.

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Purkinje cell dendrites are excitable structures with intrinsic and synaptic conductances contributing to the generation and propagation of electrical activity. Voltage-gated potassium channel subunit Kv3.3 is expressed in the distal dendrites of Purkinje cells. However, the functional relevance of this dendritic distribution is not understood. Moreover, mutations in Kv3.3 cause movement disorders in mice and cerebellar atrophy and ataxia in humans, emphasizing the importance of understanding the role of these channels. In this study, we explore functional implications of this dendritic channe

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20

Kilo, Lukas, Tomke Stürner, Gaia Tavosanis, and Anna B. Ziegler. "Drosophila Dendritic Arborisation Neurons: Fantastic Actin Dynamics and Where to Find Them." Cells 10, no. 10 (2021): 2777. http://dx.doi.org/10.3390/cells10102777.

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Neuronal dendrites receive, integrate, and process numerous inputs and therefore serve as the neuron’s “antennae”. Dendrites display extreme morphological diversity across different neuronal classes to match the neuron’s specific functional requirements. Understanding how this structural diversity is specified is therefore important for shedding light on information processing in the healthy and diseased nervous system. Popular models for in vivo studies of dendrite differentiation are the four classes of dendritic arborization (c1da–c4da) neurons of Drosophila larvae with their class-specific

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21

Kato, Mizuki, and Erik De Schutter. "Models of Purkinje cell dendritic tree selection during early cerebellar development." PLOS Computational Biology 19, no. 7 (2023): e1011320. http://dx.doi.org/10.1371/journal.pcbi.1011320.

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We investigate the relationship between primary dendrite selection of Purkinje cells and migration of their presynaptic partner granule cells during early cerebellar development. During postnatal development, each Purkinje cell grows more than three dendritic trees, from which a primary tree is selected for development, whereas the others completely retract. Experimental studies suggest that this selection process is coordinated by physical and synaptic interactions with granule cells, which undergo a massive migration at the same time. However, technical limitations hinder continuous experime

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Komendantov, Alexander O., and Giorgio A. Ascoli. "Dendritic Excitability and Neuronal Morphology as Determinants of Synaptic Efficacy." Journal of Neurophysiology 101, no. 4 (2009): 1847–66. http://dx.doi.org/10.1152/jn.01235.2007.

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The ability to trigger neuronal spiking activity is one of the most important functional characteristics of synaptic inputs and can be quantified as a measure of synaptic efficacy (SE). Using model neurons with both highly simplified and real morphological structures (from a single cylindrical dendrite to a hippocampal granule cell, CA1 pyramidal cell, spinal motoneuron, and retinal ganglion neurons) we found that SE of excitatory inputs decreases with the distance from the soma and active nonlinear properties of the dendrites can counterbalance this global effect of attenuation. This phenomen

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23

Velte, Toby J., and Richard H. Masland. "Action Potentials in the Dendrites of Retinal Ganglion Cells." Journal of Neurophysiology 81, no. 3 (1999): 1412–17. http://dx.doi.org/10.1152/jn.1999.81.3.1412.

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Action potentials in the dendrites of retinal ganglion cells. The somas and dendrites of intact retinal ganglion cells were exposed by enzymatic removal of the overlying endfeet of the Müller glia. Simultaneous whole cell patch recordings were made from a ganglion cell’s dendrite and the cell’s soma. When a dendrite was stimulated with depolarizing current, impulses often propagated to the soma, where they appeared as a mixture of small depolarizations and action potentials. When the soma was stimulated, action potentials always propagated back through the dendrite. The site of initiation of a

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Li, Haimin, Gang Chen, Bing Zhou, and Shumin Duan. "Actin Filament Assembly by Myristoylated, Alanine-rich C Kinase Substrate–Phosphatidylinositol-4,5-diphosphate Signaling Is Critical for Dendrite Branching." Molecular Biology of the Cell 19, no. 11 (2008): 4804–13. http://dx.doi.org/10.1091/mbc.e08-03-0294.

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Dendrites undergo extensive growth and branching at early stages, but relatively little is known about the molecular mechanisms underlying these processes. Here, we show that increasing the level of myristoylated, alanine-rich C kinase substrate (MARCKS), a prominent substrate of protein kinase C and a phosphatidylinositol-4,5-diphosphate [PI(4,5)P2] sequestration protein highly expressed in the brain, enhanced branching and growth of dendrites both in vitro and in vivo. Conversely, knockdown of endogenous MARCKS by RNA interference reduced dendritic arborization. Results from expression of di

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Göbel, Werner, and Fritjof Helmchen. "New Angles on Neuronal Dendrites In Vivo." Journal of Neurophysiology 98, no. 6 (2007): 3770–79. http://dx.doi.org/10.1152/jn.00850.2007.

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Imaging technologies are well suited to study neuronal dendrites, which are key elements for synaptic integration in the CNS. Dendrites are, however, frequently oriented perpendicular to tissue surfaces, impeding in vivo imaging approaches. Here we introduce novel laser-scanning modes for two-photon microscopy that enable in vivo imaging of spatiotemporal activity patterns in dendrites. First, we developed a method to image planes arbitrarily oriented in 3D, which proved particularly beneficial for calcium imaging of parallel fibers and Purkinje cell dendrites in rat cerebellar cortex. Second,

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Yuan, Q., and T. Knöpfel. "Olfactory Nerve Stimulation-Induced Calcium Signaling in the Mitral Cell Distal Dendritic Tuft." Journal of Neurophysiology 95, no. 4 (2006): 2417–26. http://dx.doi.org/10.1152/jn.00964.2005.

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Olfactory receptor neuron axons form the olfactory nerve (ON) and project to the glomerular layer of the olfactory bulb, where they form excitatory synapses with terminal arborizations of the mitral cell (MC) tufted primary dendrite. Clusters of MC dendritic tufts define olfactory glomeruli, where they involve in complex synaptic interactions. The computational function of these cellular interactions is not clear. We used patch-clamp electrophysiology combined with whole field or two-photon Ca2+ imaging to study ON stimulation-induced Ca2+ signaling at the level of individual terminal branches

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Szakal, A. K., R. L. Gieringer, M. H. Kosco, and J. G. Tew. "Isolated follicular dendritic cells: cytochemical antigen localization, Nomarski, SEM, and TEM morphology." Journal of Immunology 134, no. 3 (1985): 1349–59. http://dx.doi.org/10.4049/jimmunol.134.3.1349.

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Abstract The objectives of the present study were to determine the cytological features of isolated follicular dendritic cells (FDC), which distinguish them from other leukocytes or dendritic cell types. Consequently, we have developed methods for the fixation, peroxidase cytochemistry, and visualization of FDC, which are applicable to cytological evaluations by Nomarski optics, scanning, and transmission electron microscopy. A functionally supported identification of FDC in vitro was made possible by utilizing, in conjunction with the dendritic morphology, the cytochemically identifiable anti

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Lam, Y. W., C. L. Cox, C. Varela, and S. Murray Sherman. "Morphological Correlates of Triadic Circuitry in the Lateral Geniculate Nucleus of Cats and Rats." Journal of Neurophysiology 93, no. 2 (2005): 748–57. http://dx.doi.org/10.1152/jn.00256.2004.

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We used an in vitro slice preparation of the lateral geniculate nucleus in cats and rats to study morphological correlates of triadic circuitry in relay cells. The three triadic elements involve a retinal synapse onto a GABAergic dendritic terminal of an interneuron, a synapse from the same retinal terminal onto a relay cell dendrite, and a synapse from the same interneuron terminal onto the same relay cell dendrite. We made whole cell recordings and labeled cells with biocytin. Previous methods were used to identify triadic circuitry based on evidence that the retinal terminal activates a met

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Foley, J. F. "From Dendrite to Dendritic." Science Signaling 1, no. 17 (2008): ec152-ec152. http://dx.doi.org/10.1126/stke.117ec152.

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Sharp, David J., Wenqian Yu, Lotfi Ferhat, Ryoko Kuriyama, David C. Rueger, and Peter W. Baas. "Identification of a Microtubule-associated Motor Protein Essential for Dendritic Differentiation." Journal of Cell Biology 138, no. 4 (1997): 833–43. http://dx.doi.org/10.1083/jcb.138.4.833.

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The quintessential feature of the dendritic microtubule array is its nonuniform pattern of polarity orientation. During the development of the dendrite, a population of plus end–distal microtubules first appears, and these microtubules are subsequently joined by a population of oppositely oriented microtubules. Studies from our laboratory indicate that the latter microtubules are intercalated within the microtubule array by their specific transport from the cell body of the neuron during a critical stage in development (Sharp, D.J., W. Yu, and P.W. Baas. 1995. J. Cell Biol. 130:93– 104). In ad

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Hamze, Kassem, Sabine Autret, Krzysztof Hinc, et al. "Single-cell analysis in situ in a Bacillus subtilis swarming community identifies distinct spatially separated subpopulations differentially expressing hag (flagellin), including specialized swarmers." Microbiology 157, no. 9 (2011): 2456–69. http://dx.doi.org/10.1099/mic.0.047159-0.

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The non-domesticated Bacillus subtilis strain 3610 displays, over a wide range of humidity, hyper-branched, dendritic, swarming-like migration on a minimal agar medium. At high (70 %) humidity, the laboratory strain 168 sfp + (producing surfactin) behaves very similarly, although this strain carries a frameshift mutation in swrA, which another group has shown under their conditions (which include low humidity) is essential for swarming. We reconcile these different results by demonstrating that, while swrA is essential for dendritic migration at low humidity (30–40 %), it is dispensable at hig

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Yap, Chan Choo, Laura Digilio, Lloyd P. McMahon, A. Denise R. Garcia, and Bettina Winckler. "Degradation of dendritic cargos requires Rab7-dependent transport to somatic lysosomes." Journal of Cell Biology 217, no. 9 (2018): 3141–59. http://dx.doi.org/10.1083/jcb.201711039.

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Neurons are large and long lived, creating high needs for regulating protein turnover. Disturbances in proteostasis lead to aggregates and cellular stress. We characterized the behavior of the short-lived dendritic membrane proteins Nsg1 and Nsg2 to determine whether these proteins are degraded locally in dendrites or centrally in the soma. We discovered a spatial heterogeneity of endolysosomal compartments in dendrites. Early EEA1-positive and late Rab7-positive endosomes are found throughout dendrites, whereas the density of degradative LAMP1- and cathepsin (Cat) B/D–positive lysosomes decre

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Risner, Michael L., Silvia Pasini, Nolan R. McGrady, and David J. Calkins. "Bax Contributes to Retinal Ganglion Cell Dendritic Degeneration During Glaucoma." Molecular Neurobiology 59, no. 3 (2022): 1366–80. http://dx.doi.org/10.1007/s12035-021-02675-5.

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AbstractThe BCL-2 (B-cell lymphoma-2) family of proteins contributes to mitochondrial-based apoptosis in models of neurodegeneration, including glaucomatous optic neuropathy (glaucoma), which degrades the retinal ganglion cell (RGC) axonal projection to the visual brain. Glaucoma is commonly associated with increased sensitivity to intraocular pressure (IOP) and involves a proximal program that leads to RGC dendritic pruning and a distal program that underlies axonopathy in the optic projection. While genetic deletion of the Bcl2-associated X protein (Bax-/-) prolongs RGC body survival in mode

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Kelliher, Michael T., Yang Yue, Ashley Ng, et al. "Autoinhibition of kinesin-1 is essential to the dendrite-specific localization of Golgi outposts." Journal of Cell Biology 217, no. 7 (2018): 2531–47. http://dx.doi.org/10.1083/jcb.201708096.

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Neuronal polarity relies on the selective localization of cargo to axons or dendrites. The molecular motor kinesin-1 moves cargo into axons but is also active in dendrites. This raises the question of how kinesin-1 activity is regulated to maintain the compartment-specific localization of cargo. Our in vivo structure–function analysis of endogenous Drosophila melanogaster kinesin-1 reveals a novel role for autoinhibition in enabling the dendrite-specific localization of Golgi outposts. Mutations that disrupt kinesin-1 autoinhibition result in the axonal mislocalization of Golgi outposts. Autoi

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Gillessen, Thomas, and Christian Alzheimer. "Amplification of EPSPs by Low Ni2+- and Amiloride-Sensitive Ca2+ Channels in Apical Dendrites of Rat CA1 Pyramidal Neurons." Journal of Neurophysiology 77, no. 3 (1997): 1639–43. http://dx.doi.org/10.1152/jn.1997.77.3.1639.

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Gillessen, Thomas and Christian Alzheimer. Amplification of EPSPs by low Ni2+- and amiloride-sensitive Ca2+ channels in apical dendrites of rat CA1 pyramidal neurons. J. Neurophysiol. 77: 1639–1643, 1997. Distal synaptic input to hippocampal CA1 pyramidal neurons was evoked by electrical stimulation of afferent fibers in outer stratum radiatum. Whole cell recordings from CA1 cell somata served to monitor excitatory postsynaptic potential (EPSP) envelopes after dendritic processing. To probe a functional role of low-voltage-activated Ca2+ current [or T current ( I T)] in the apical dendrite, EP

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Shibata, A., M. V. Wright, S. David, L. McKerracher, P. E. Braun, and S. B. Kater. "Unique Responses of Differentiating Neuronal Growth Cones to Inhibitory Cues Presented by Oligodendrocytes." Journal of Cell Biology 142, no. 1 (1998): 191–202. http://dx.doi.org/10.1083/jcb.142.1.191.

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During central nervous system development, neurons differentiate distinct axonal and dendritic processes whose outgrowth is influenced by environmental cues. Given the known intrinsic differences between axons and dendrites and that little is known about the response of dendrites to inhibitory cues, we tested the hypothesis that outgrowth of differentiating axons and dendrites of hippocampal neurons is differentially influenced by inhibitory environmental cues. A sensitive growth cone behavior assay was used to assess responses of differentiating axonal and dendritic growth cones to oligodendr

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Cho, Kwang-Hyun, Jin Hwa Jang, Hyun-Jong Jang, et al. "Subtype-Specific Dendritic Ca2+ Dynamics of Inhibitory Interneurons in the Rat Visual Cortex." Journal of Neurophysiology 104, no. 2 (2010): 840–53. http://dx.doi.org/10.1152/jn.00146.2010.

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The Ca2+ increase in dendrites that is evoked by the backpropagation of somatic action potentials (APs) is involved in the activity-dependent modulation of dendritic and synaptic functions that are location dependent. In the present study, we investigated dendritic Ca2+ dynamics evoked by backpropagating APs (bAPs) in four subtypes of inhibitory interneurons classified by their spiking patterns: fast spiking (FS), late spiking (LS), burst spiking (BS), and regular-spiking nonpyramidal (RSNP) cells. Cluster analysis, single-cell RT-PCR, and immunohistochemistry confirmed the least-overlapping n

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Yang, Sihui Z., and Jill Wildonger. "Golgi Outposts Locally Regulate Microtubule Orientation in Neurons but Are Not Required for the Overall Polarity of the Dendritic Cytoskeleton." Genetics 215, no. 2 (2020): 435–47. http://dx.doi.org/10.1534/genetics.119.302979.

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Microtubule-organizing centers often play a central role in organizing the cellular microtubule networks that underlie cell function. In neurons, microtubules in axons and dendrites have distinct polarities. Dendrite-specific Golgi “outposts,” in particular multicompartment outposts, have emerged as regulators of acentrosomal microtubule growth, raising the question of whether outposts contribute to establishing or maintaining the overall polarity of the dendritic microtubule cytoskeleton. Using a combination of genetic approaches and live imaging in a Drosophila model, we found that dendritic

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Steele, V. J., and D. H. Steele. "Cellular organization and fine structure of type II microtrich sensilla in gammaridean amphipods (Crustacea)." Canadian Journal of Zoology 77, no. 1 (1999): 88–107. http://dx.doi.org/10.1139/z98-185.

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The cellular organization of type II microtrich sensilla was studied in male Anonyx lilljeborgi Boeck, 1871 (Lysianassoidea) by light and transmission electron microscopy. The sensillum consists of two bipolar sensory neurons and three concentric sheath cells. The sensory cell bodies are subepidermal. In each sensillum both dendrites are enclosed by the thecogen cell process. The inner dendritic segments are filled with mitochondria and lucent vesicles and expand in the epidermis into a spindle-shaped swelling. One of the neurons gives rise to two cilia and the second to a single cilium. These

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M.D. Pathology, Vishal Dhingra. "Follicular Dendritic Cell Sarcoma in Colon: A Rare Case Report." Journal of Medical Science And clinical Research 05, no. 04 (2017): 20035–38. http://dx.doi.org/10.18535/jmscr/v5i4.50.

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Curti, Antonio, Elisa Ferri, Simona Pandolfi, Alessandro Isidori, and Roberto M. Lemoli. "Dendritic Cell Differentiation." Journal of Immunology 172, no. 1 (2003): 3–4. http://dx.doi.org/10.4049/jimmunol.172.1.3.

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&NA;. "Dendritic cell vaccines." Reactions Weekly &NA;, no. 1231 (2008): 12. http://dx.doi.org/10.2165/00128415-200812310-00035.

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Mosca, Paul, J. "Dendritic cell vaccines." Frontiers in Bioscience 12, no. 8-12 (2007): 4050. http://dx.doi.org/10.2741/2371.

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Proudfoot, Owen, Dodie Pouniotis, Kuo-Ching Sheng, Bruce E. Loveland, and Geoffrey A. Pietersz. "Dendritic cell vaccination." Expert Review of Vaccines 6, no. 4 (2007): 617–33. http://dx.doi.org/10.1586/14760584.6.4.617.

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Pitzer, Ashley L., and Annet Kirabo. "Dendritic Cell A20." Circulation Research 125, no. 12 (2019): 1067–69. http://dx.doi.org/10.1161/circresaha.119.316198.

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Vyas, Jatin M. "The dendritic cell." Virulence 3, no. 7 (2012): 601–2. http://dx.doi.org/10.4161/viru.22975.

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Da Silva, Kevin. "Dendritic cell demise." Nature Medicine 18, no. 1 (2012): 34. http://dx.doi.org/10.1038/nm.2642.

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Van Epps, Heather L. "Dendritic cell paralysis." Journal of Experimental Medicine 203, no. 7 (2006): 1621. http://dx.doi.org/10.1084/jem.2037iti4.

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McCarter, Martin. "Dendritic Cell Enumeration." Annals of Surgical Oncology 15, no. 7 (2008): 2058. http://dx.doi.org/10.1245/s10434-008-9857-6.

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Fogg, Christiana N. "Dendritic cell dynamics." Science 363, no. 6431 (2019): 1052.17–1054. http://dx.doi.org/10.1126/science.363.6431.1052-q.

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