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1

Colombo, Armando W. [Verfasser], Klaus [Akademischer Betreuer] Feldmann, Klaus [Gutachter] Feldmann, W. [Gutachter] Bär, Klaus [Herausgeber] Feldmann, and Manfred [Herausgeber] Geiger. "Development and Implementation of Hierarchical Control Structures of Flexible Production Systems Using High Level Petri Nets / Armando Walter Colombo ; Gutachter: Klaus Feldmann, W. Bär ; Betreuer: Klaus Feldmann ; Herausgeber: Klaus Feldmann, Manfred Geiger." Erlangen : Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 1998. http://nbn-resolving.de/urn:nbn:de:bvb:29-opus4-136547.

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Colombo, Armando Walter [Verfasser], Klaus [Akademischer Betreuer] Feldmann, Klaus [Gutachter] Feldmann, W. [Gutachter] Bär, Klaus [Herausgeber] Feldmann, and Manfred [Herausgeber] Geiger. "Development and Implementation of Hierarchical Control Structures of Flexible Production Systems Using High Level Petri Nets / Armando Walter Colombo ; Gutachter: Klaus Feldmann, W. Bär ; Betreuer: Klaus Feldmann ; Herausgeber: Klaus Feldmann, Manfred Geiger." Erlangen : Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 1998. http://d-nb.info/1209741288/34.

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Liu, Jingyu. "Development of bioinspired composites with hierarchical structures." Thesis, Queensland University of Technology, 2020. https://eprints.qut.edu.au/205618/1/Jingyu_Liu_Thesis.pdf.

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This research presents a novel method for fabrication of bioinspired composites with hierarchical structures, developed via combined 3D print and freeze casting techniques. Mechanical characterization and numerical modelling are conducted at different material length scales to understand the structure-property relationship. Tailored mechanical behaviour and biocompatibility have been achieved, demonstrating great potential for biomedical applications such as personalized implants and scaffolds. This work also provides some new insights on the strengthening and toughening mechanisms in biomaterials.
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de, Leon Al Caimol. "Development, Fabrication, and Application of Hierarchically-Structured Polymer Systems." Case Western Reserve University School of Graduate Studies / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=case1448375702.

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Xu, Yansong W. "A hierarchical diagnostic system for STUMPS-based BIST structures." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape4/PQDD_0013/MQ60197.pdf.

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Sawaragi, Tetsuo. "Intelligent Decision Support System Based on Hierarchical Causal Knowledge Structures." Kyoto University, 1987. http://hdl.handle.net/2433/74703.

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Haj, Hassine Sammi. "Investigation of Navigation on Mobile Websites with Hierarchical Information Structures : A Development Basis for Mobile Hierarchical Navigation." Thesis, Uppsala universitet, Institutionen för informationsteknologi, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-207621.

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In this thesis issues regarding hierarchical navigation structures on mobile websites have been investigated with focus on usability. The goal has been to provide a complementary basis for hierarchical mobile navigation development. Two mobile website prototypes with the same hierarchical structured content, but with different types of navigation solutions, were developed and tested on test persons. Due to a relatively low amountof test persons, the tests purpose was to provide qualitative information regarding the issue of hierarchal mobile navigation, which then could be discussed and analysed. The results of the thesis points to relevant usability issues that can arise if hierarchical structure is used on mobile websites, and explains aspects to considerate during the development of such sites.
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Salger, Frank. "Verification in the hierarchical development of reactive systems /." [S.l. : s.n.], 2001. http://www.bsz-bw.de/cgi-bin/xvms.cgi?SWB9216991.

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Gledhill, Peter L. "Cutting and deployment system development for decommissioning of underwater steel structures." Thesis, University of Aberdeen, 2012. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=196133.

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This thesis was stimulated by the requirement to decommission offshore steel structures in the North Sea Offshore Oil and Gas Industry, but applies worldwide, where Oil and Gas production has ceased. It initially shows the UK Government assessment of the scale of decommissioning in the UKCS where there are several hundred structures with associated pipelines, risers and wellheads that have to be cut into sub-structures and individual pieces and then removed. Factors other than cessation of production drive the sequence and timing of structural decommissioning, such as the price of oil &gas and what new development might require already installed infrastructure. The nature of decommissioning of underwater steel lattice structure of offshore oil platforms called ‘jackets’ and underwater infrastructure is briefly discussed with the focus on cutting. The comparison of the performance of different underwater cutting tools currently most used in decommissioning is investigated with respect to two new underwater cutting techniques not only in terms of speed of cut but also in terms of deployment time and infrastructure requirements. A number of mainstream cutting tools and deployment systems are briefly introduced to provide a background, showing the range of tools preceding those investigated in more detail in terms of cutting and deployment efficiency. During the initial cutting research it was considered that fibre lasers had developed sufficiently in terms of power density, size and cost to be applied to underwater cutting. They were considered to have potential benefits over other underwater cutting techniques due to the continually increasing power density at the cut and have the advantage of a small envelope due to the small size of the potential cutting head The potential footprint of the laser head was envisaged to be similar to that of the rotating electrode arc tool therefore the deployment issues investigated might apply to both. The later development There is little published information on underwater cutting by laser particularly for the Oil and Gas Industry except for application to cutting rock for drilling. Research has been biased towards the nuclear industry using manufacturing techniques for surface treatment and cooling to reduce stress cracking. Fibre lasers are expensive to buy and logistically difficult to rent therefore it was considered that 1.2 kW CO2 laser at the University of Aberdeen (UoA) could be employed in obtaining an insight into the cutting and deployment issues concerned. Thus, the author designed, built and tested an underwater laser cutting head that would interface to the CO2 laser and would work at different orientations, fully submerged underwater in a tank. The trials were designed to assess the relationship of cutting parameters and performance at three orthogonal attitudes underwater, (beam downward, horizontal and upward pointing) to represent the orthogonal approach to horizontal and vertical primary axis tubular members, that comprise a jacket’s construction. The cutting parameters and their effects were then analysed to determine trends, behaviour and technical issues. Although an underwater laser cutting system could use a fibre laser, the CO2 laser enabled preliminary tests to be carried out and the viability of a cutting head to be explored. In the conclusion the design and performance of the laser cutting head is assessed with respect to the performance of other main-stream underwater cutting tools developed earlier. Offshore deployment of the laser cutting head is also discussed. Recommendations for future research and development work, to enable the realisation of underwater laser cutting, are presented.
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Jaffer, Seema. "Development of modular system structures for assembling microfluidic components of disparate materials /." Burnaby B.C. : Simon Fraser University, 2007. http://ir.lib.sfu.ca/handle/1892/9292.

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Thesis (M.A.Sc.) - Simon Fraser University, 2007.<br>Theses (School of Engineering Science) / Simon Fraser University. Senior supervisor: Dr. Bonnie Gray -- School of Engineering Science. Also issued in digital format and available on the World Wide Web.
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Kok, Wing Hang (Ronald). "Development of a wireless MEMS inertial system for health monitoring of structures." Link to electronic thesis, 2004. http://www.wpi.edu/Pubs/ETD/Available/etd-11244-122741/.

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Thesis (M.S.)--Worcester Polytechnic Institute.<br>Keywords: angular rate; cantilever; wireless; RF; microcontroller; tilt and rotation; health monitoring; inertial sensors; MEMS. Includes bibliographical references (p. 139-145).
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Potiyaraj, Pranut. "Mathematical modelling and development of a CAD/CAM system for 3d woven structures." Thesis, University of Manchester, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.488318.

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Marks, Mary Catherine. "Development of a System for the Observation of Task Structures in Physical Education." The Ohio State University, 1988. http://rave.ohiolink.edu/etdc/view?acc_num=osu1392821384.

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Hackenberger, Christian. "Development of models to implement low dimensional structures in correlated electronic systems." kostenfrei, 2006. http://d-nb.info/992037174/34.

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Grant, Eleanor. "The development of corticothalamic and corticotectal connections in the murine visual system." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:4266d733-fa8f-4cc3-b963-91ba0e671ce6.

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All peripheral sensory information is represented in the thalamus before being transmitted to the cortex, with the exception of olfaction. The thalamus projects to all areas of the neocortex and all neocortical areas project to the thalamus. I am interested in the development of three corticothalamic populations which are anatomically and functionally distinct; they project to different thalamic nuclei and generate different post-synaptic responses. Layer V fibres project exclusively to higher order thalamic nuclei. These projections drive thalamic neuron activity and mediate a trans-thalamic cortico-cortical relay. Layer VI and VIb fibres project to both first order and higher order thalamic nuclei. These projections modulate thalamic neuron activity and mediate feedback to the thalamus. Using three transgenic mouse lines I demonstrate that developing corticothalamic fibres target the specific groups of thalamic nuclei to which they project in adulthood. Rbp4-Cre::tdTomato labels layer V; Ntsr1-Cre::tdTomato labels layer VI; Golli-τ-eGFP labels layer VI and VIb. By P4 layer V fibres arborise densely in higher order nuclei but do not innervate the first order nuclei at any age. In contrast, at this age VI and VIb fibres densely innervate the first order ventral posterior-medial nucleus (VPM), as well as higher order nuclei. Layer VI and VIb fibres accumulate outside the dorsal Lateral Geniculate Nucleus (dLGN) from P2 before entering at P6. During this waiting period, retinal fibres transmit spontaneous waves of activity to the dLGN. To assess whether retinal input regulates corticothalamic circuit development I performed monocular enucleation. I demonstrate that after loss of retinal input, layer VI and VIb fibres enter the dLGN prematurely, by P2. Furthermore layer V fibres which target the retino-recipient superior colliculus also enter prematurely following enucleation. These results suggest there may be a retinal mechanism which regulates the timing of corticofugal ingrowth to joint retinal/cortical targets. The loss of retinal driver input to the dLGN also induces layer V driver fibres to aberrantly enter the first order dLGN. These results are the first to show cross-hierarchical rewiring after losing peripheral sensory input. The role of peripheral activity in the developing nervous system is underscored by activity dependent molecular mechanisms. I therefore performed a microarray gene expression experiment to systematically analyse molecular changes in the dLGN following enucleation. The expression of numerous genes is altered following enucleation including potassium channels Kcnk9 and Kcnn3, kinase pathway mediators, Shc3 and Dgkk, and immediate early genes BDNF, Egr1 and Egr2. The majority of genes regulated by enucleation are regulated in the opposite direction over development indicating that the loss of the retinal input delays maturation of the dLGN transcriptome. In this thesis I demonstrate that early corticothalamic development targets specific thalamic nuclei. Using the visual system as a model I demonstrate that retinal input regulates corticothalamic development and contributes to the transcriptome of thalamic nuclei.
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CUI, Yao. "Development of Joint Systems Using SFRCC for Enhanced Seismic Performance of Steel Structures." 京都大学 (Kyoto University), 2009. http://hdl.handle.net/2433/85393.

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Kyoto University (京都大学)<br>0048<br>新制・課程博士<br>博士(工学)<br>甲第14935号<br>工博第3162号<br>新制||工||1474(附属図書館)<br>27373<br>UT51-2009-M849<br>京都大学大学院工学研究科建築学専攻<br>(主査)教授 中島 正愛, 教授 金子 佳生, 准教授 吹田 啓一郎<br>学位規則第4条第1項該当
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Moodi, Faramarz. "Development of a knowledge-based system for the repair and maintenance of concrete structures." Thesis, University of Newcastle Upon Tyne, 2001. http://hdl.handle.net/10443/481.

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Information Technology (IT) can exploit strategic opportunities for new ways of facilitating information and data exchange and the exchange of expert and specialist opinions in any field of engineering. Knowledge-Based Systems are sophisticated computer programs which store expert knowledge on specific subject and are applied to a broad range of engineering problems. Integrated Database applications have facilitated the essential capability of storing data to overcome an increasing information malaise. Integrating these areas of Information Technology (IT) can be used to bring a group of experts in any field of engineering closer together by allowing them to communicate and exchange information and opinions. The central feature of this research study is the integration of these hitherto separate areas of Information Technology (IT). In this thesis an adaptable Graphic User Interface Centred application comprising a Knowledge-Based Expert System (DEMARECEXPERT), a Database Management System (REPCON) and Evaluation program (ECON) alongside visualisation technologies is developed to produce an innovative platform which will facilitate and encourage the development of knowledge in concrete repair. Diagnosis, Evaluation, MAintenance and REpair of Concrete structures (DEMAREC) is a flexible application which can be used in four modes of Education, Diagnostic, Evaluation and Evolution. In the educational mode an inexperienced user can develop a better understanding of the repair of concrete technology by navigating through a database of textual and pictorial data. In the diagnostic mode, pictures and descriptive information taken from the database and performance of the expert system (DEMAREC-EXPERT) are used in a way that makes problem solving and decision making easier. The DEMAREC-EXPERT system is coupled to the REPCON (as an independent database) in order to provide the user with recommendations related to the best course required for maintenance and in the selection of materials and methods for the repair of concrete. In the evaluation mode the conditions observed are described in unambiguous terms that can be used by the user to be able to take engineering and management actions for the repair and maintenance of the structure. In the evolution mode of the application, the nature of distress, repair and maintenance of concrete structures within the extent of the database management system has been assessedT. he new methodology of data/usere valuation could have wider implications in many knowledge rich areas of expertise. The benefit of using REPCON lies in the enhanced levels of confidence which can be attributed to the data and to contribution of that data. Effectively, REPCON is designed to model a true evolution of a field of expertise but allows that expertise to move on in faster and more structured manner. This research has wider implications than within the realm of concrete repair. The methodology described in this thesis is developed to provide tecýnology transfer of information from experts, specialists to other practitioners and vice versa and it provides a common forum for communication and exchange information between them. Indeed, one of the strengths of the system is the way in which it allows the promotion and relegation of knowledge according to the opinion of users of different levels of ability from expert to novice. It creates a flexible environment in which an inexperienced user can develop his knowledge in maintenance and concrete repair structures. It is explained how an expert and a specialist can contribute his experience and knowledge towards improving and evolving the problem solving capability of the application.
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Pepe, Christian. "Comparative design of Dual-System structures through the development of a seismic-design oriented software." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2012. http://amslaurea.unibo.it/3649/.

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Martino, Aldo. "Development of an integrated system for the geometry definition, load determination and analysis of steel structures." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp01/MQ27003.pdf.

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Rozumilowicz, Beatrice. "Organizational structures and programmatic stances : the development of the political party system in Poland, 1989-1997." Thesis, University of Oxford, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.323742.

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Kral, Zachary Tyler. "Development of a decentralized artificial intelligence system for damage detection in composite laminates for aerospace structures." Diss., Wichita State University, 2013. http://hdl.handle.net/10057/10612.

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Because of economic impact that results from downtime, aircraft maintenance is an important issue in the aerospace industry. In-service structures will decay over time. Compared to low-cycle loading structures, aerospace structures experience extreme loading conditions, resulting in rapid crack propagation. The research involved in this dissertation concerns development of the initial stages of structural health monitoring (SHM) system that includes a network of ultrasonic testing sensors with artificial intelligence capable of detecting damage before structure failure. A series of experiments examining the feasibility of ultrasonic sensors to detect the initial onset of damage on a composite laminate, similar in structure to that used in aerospace components, was conducted. An artificial neural network (ANN) with the best accuracy was found to be a hybrid of a self-organizing map (SOM) with a feed-forward hidden and output layer. This was used for the single actuator-to-sensor scans on a composite laminate with simulated damage. It was concluded that a decentralized network of sensors was appropriate for such a system. The small four-sensor system was proven to be capable of predicting the presence of damage within a scanning area on a composite laminate, as well as predict the location once damage was detected. The main experimentation for this dissertation involved four ultrasonic sensors operated in a pitch-catch configuration. Simulated damage, verified through experimentation, was placed at various locations in the scanning area of interest. Signals obtained from the ultrasonic sensors were analyzed by a multi-agent system in which each agent describes an ANN. The system was trained to determine damage size. A second multi-agent system was constructed to determine the location of the detected damage. The architecture was similar to the damage-sizing system. Results demonstrated that with the artificial intelligence post-processing of ultrasonic sensors, 95% confidence can be obtained for detecting and locating damage that is 0.375 in. in diameter, which was verified through a bootstrap method. This dissertation validated the initial stages of constructing such a network of ultrasonic sensors. Future research in this area could involve combining the four-sensor network into a larger network of sensors by means of multi-agent processing (i.e., developing scanning regions). The novel method presented here provides the basis for the development of the SHM system for typical aerospace structures.<br>Thesis (Ph.D.)--Wichita State University, College of Engineering, Dept. of Aerospace Engineering.
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Hopping, Jakob A. "Development of rapidly deployable structures for military applications : a system based approach to command post facilities." Thesis, Massachusetts Institute of Technology, 2006. http://hdl.handle.net/1721.1/36747.

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Thesis (S.B.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2006.<br>Vita.<br>Includes bibliographical references (p. 91-94).<br>Today's battlespace is the most dynamic in recorded history. Accompanying other military improvements, Command and Control (C2) technology has also been modernized. In spite of advances in technology, it currently takes six times as long to deploy a Command Post (CP) as it did eight years ago. This decline in performance results in poor communication with forward units due to an increased distance between the units and the CP. This performance decline also increases the danger posed to command centers by enemy elements in the rear. Although each component of a modern CP functions well, CP structures are slow to deploy because many of the components of the command structure are developed separately to fulfill specific functions. Separately, these components are quick and innovative. Combined, they are cumbersome and labor intensive to assemble. The command structure must be viewed as a system that requires an encompassing solution. This thesis presents a rapidly deployable CP structure developed using a system based approach.<br>(cont.) The functional elements of a Command Post were analyzed and a comprehensive structure was designed to enhance the speed of CP establishment. Also, the appropriate background theory for structural and safety analysis was developed and applied to the resulting design. The proposed design, termed the Automated Command Post (ACP), is capable of establishing Command and Control in a mere fifteen minutes from start to finish; this is a 92% improvement over existing CP structures. In order to maximize the potential usefulness of the physical space within the ACP, the recommended ACP layout was constructed by modifying existing command post layouts using network theory. The ACP is an air-supported structure that requires a nominal pressure of only 0.036 psi to withstand up to 75 mph winds. Also, the ACP inflation system has an estimated fuel cost of only '/2 a gallon per day to maintain this pressure.<br>by Jakob A. Hopping.<br>S.B.
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Martino, Aldo (Aldo Emilio) Carleton University Dissertation Engineering Civil and Environmental. "Development of an integrated system for the geometry definition, load determination and analysis of steel structures." Ottawa, 1997.

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Raby, Douglas Allan. "Development of a system architecture and applications for an integrated computer software system for the analysis and design of steel structures." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape8/PQDD_0017/MQ48372.pdf.

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Leslie, Benjamin John. "The Development and Validation of a Non-tearing Floor Precast Concrete Structural System for Seismic Regions." Thesis, University of Canterbury. Civil and Natural Resources Engineering, 2010. http://hdl.handle.net/10092/4924.

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Traditional seismic design philosophy for reinforced concrete seismic frame structures localises damage and inelastic deformation to regions of significant plasticity within the beam (plastic hinge zones) during a severe earthquake event. Collapse prevention of the frame is applied through capacity design methods, requiring the maximum expected flexural strength of the beam plastic hinges to be reliably assessed in order to design for, and ensure, the predominantly elastic flexural response of the columns in the frame. Previous experimental and numerical investigations have shown that significant and detrimental damage to the frame and floor system occurs due to the formation and elongation of ductile beam plastic hinges; requiring extensive post-earthquake repair or demolition with likely loss of function of the building. This poses significant economic consequences to occupiers of the building, as the time required to reinstate the integrity of the structural and non-structural building components is often lengthy. More importantly, it has been highlighted that the interaction between elongating ductile plastic hinges and the accompanying floor system enhances the flexural strength of the beam hinges, altering the distribution of forces in the seismic frame compared to that assumed during capacity design. Research has shown that the consideration of frame-floor interaction in current New Zealand design codes significantly underestimates the flexural strength enhancement of beam plastic hinges, threatening the hierarchy of strength and collapse prevention mechanisms employed in capacity design. Recent research has introduced change in the design philosophy of precast concrete seismic frames. Rather than designing for localised damage in the frame, unique Non-tearing (of the floor) connection details have been developed which provide a gap or slot between the end of the beam and column face and force connection rotation to occur about a shallow hinge located at the top of the beam, thereby avoiding the formation of plastic hinges and associated beam elongation effects altogether. Research investigations have shown that Non-tearing connections successfully minimise damage to the structural frame and floor, while providing seismic energy dissipation characteristics at least comparable to that of traditional reinforced concrete connections. In this research, the mechanics of different non-tearing connection arrangements were investigated and original theory introduced for the aspects of connection behaviour which diverged from fundamental reinforced concrete design. A variety of precast concrete non-tearing connection details were developed, with the design focus placed on economic and construction efficiency in order to encourage the rapid implementation of non-tearing connection technology into New Zealand construction industry. The performance of the developed connection details were explored and assessed experimentally and analytically. A two bay precast concrete frame with precast floor system was tested under a demanding reversed cyclic, quasi-static loading protocol using displacement control. The seismic response of the non-tearing connection details employed in the test frame successfully minimised damage to the frame and floor systems. Only minor repair of one primary crack at each connection between the floor diaphragm and supporting beam would be required after a design level earthquake. Issues encountered with buckling of the longitudinal reinforcement in the bottom of the beam reduced the connection performance at high levels of drift. However, detailing measures were successfully employed in successive tests which improved the drift capacity of the connections. Detailing improvements to enhance the seismic response of the developed non-tearing connections were recommended based observations from the frame test. Numerical analysis of the non-tearing connection details was performed using simple rotational and compound spring models, with the key features of the experimental response captured with excellent accuracy. The analytical models were constructed using engineering theory, rather than by calibration with experimental observations. The modelling assumptions and principles adopted in the analysis have been presented for use in design offices or future research programmes when designing and analysing seismic frames using non-tearing connections. This research successfully contributed to the development and progression of non-tearing frame technology. With further research and the refinement of construction details, non-tearing floor connections exhibit impressive potential for providing superior seismic safety, performance and efficiency in precast concrete seismic frame buildings.
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Rupert, Francois Johannes. "Control of surfaces in confined spaces : Tab-aileron control system development." Thesis, Stellenbosch : University of Stellenbosch, 2011. http://hdl.handle.net/10019.1/6605.

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Thesis (MScEng (Electrical and Electronic Engineering))--University of Stellenbosch, 2011.<br>ENGLISH ABSTRACT: This thesis forms part of the Control Surfaces in Confined Spaces (CoSICS) project conducted at Stellenbosch University. The aim of this project is reduction of control surface actuator footprints on the existing wing structures of commercial airliners such as the Airbus A320 and A330. This is achieved by reducing control surface hinge moments through the application of trailing edge tabs. This results in smaller actuator requirements. The first tier of the project focussed on the geometric optimisation of the tab applied to an aileron. This thesis focusses on the development of dynamic control of the aileron through either tab-only or concurrent tab and aileron actuation. In the effort to develop dynamic control, a fully coupled generalised dynamic model of the tab and aileron is derived and presented. Through linearisation of this model, linear controllers are developed. Two distinctly different controllers are presented; the first controller makes use of classical methods for control of the tab-only actuated aileron and the second controller makes use of modern control techniques such as full state feedback to facilitate controlled concurrent tab and aileron actuation. Each proposed controller is evaluated in terms of dynamic performance, robustness, disturbance rejection and noise immunity. Based on the controller development, a summary of dynamic actuator requirements is given. Practical verification of the model and the controller performance is then undertaken. The development of the necessary hardware and software is also presented. The concept of aileron control through tab-only actuation and concurrent tab and aileron actuation is then validated. Conclusion are then drawn about the accuracy of the theoretical model and the practical performance of the controllers. The thesis is concluded with recommendations for future work to increase the fidelity of the model. Important aspects about the practical implementation of the concept on commercial jetliners are also summarised.<br>AFRIKAANSE OPSOMMING: Hierdie tesis is deel van die Control Surfaces in Confined Spaces1 projek by Stellenbosch Universiteit. Die doel van hierdie projek behels die verkleining van die aktueerder spasie en ondersteunings struktuur vereistes, op die bestaande vlerk struktuur van kommersiële vliegtuie soos die Airbus A320 en Airbus A330. Dit is bereik deur die vermindering van die beheeroppervlak skarnier se draaimoment met behulp van aerodinamiese hulpvlakke. Kleiner aktueerders word dus benodig. Die eerste stadium van die projek fokus op die geometriese optimisering van die hulpvlak op ’n aileron. Hierdie tesis fokus op die ontwikkeling van dinamiese beheer van die aileron deur middel van hulpvlak aktueering alleenlik of met die gelyktydige aktueering van die hulpvlak en aileron. In die proses van onwikkeling is ’n volgekoppelde veralgemeende dinamiese model van die hulpvlak en aileron afgelei en voorgelê. Deur middel van linearisasie van die model is linieêre beheerders ontwikkel. Tans is twee verskillende beheerders ontwikkel. Die eerste beheerder is gebaseer op die klassieke metodes en maak staat op die aktueering van die hulpvlak alleenlik. Die tweede beheerder maak gebruik van moderne beheer tegnieke soos vol toestand terugvoer om gelyktydige hulpvlak en aileron aktueering te realiseer. Die beheerders is elk geëvalueer in terme van dinamiese gedrag, robuustheid, versteurings verwerping en ruis verwerping. Die beheerstelsel ontwikkeling lei tot ’n opsomming van die dinamiese aktueerder vereistes. Dit word gevolg deur praktiese verifikasie van die model en die beheerstelsel gedrag. ’n Opsomming van die ontwikkeling van nodige hardeware en sagteware word voorgelê. In hierdie proses is die konsep van beide hulpvlak alleenlike aktueering en gelyktydige hulpvlak en aileron aktueering bewys. Gevolgtrekkings word gemaak oor die akkuraatheid van die model en die praktiese gedrag van die beheerders. Die tesis word afgerond met voorstelle vir toekomstige werk wat die model se betroubaarheid kan verbeter. Verder word belangrike punte oor die praktiese aspekte van konsep implementering op kommersiële vliegtuie ook uitgelig.
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Le, Dong D. Vaidyanathan Vijay Varadarajan. "Electrical resistivity as a measure of change of state in substrates design, development and validation of a microprocessor-based system /." [Denton, Tex.] : University of North Texas, 2009. http://digital.library.unt.edu/ark:/67531/metadc12149.

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Vikas, Sharma. "Development of Space-Time Finite Element Method for Seismic Analysis of Hydraulic Structures." Kyoto University, 2018. http://hdl.handle.net/2433/235094.

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Kyoto University (京都大学)<br>0048<br>新制・課程博士<br>博士(農学)<br>甲第21374号<br>農博第2298号<br>新制||農||1066(附属図書館)<br>学位論文||H30||N5147(農学部図書室)<br>京都大学大学院農学研究科地域環境科学専攻<br>(主査)教授 村上 章, 教授 藤原 正幸, 教授 渦岡 良介<br>学位規則第4条第1項該当
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Svensson, Marcus. "A Reporting System for a Device Management Application." Thesis, Linköping University, Department of Computer and Information Science, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-16488.

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<p>Device Management Applications are applications which are used to manage software on devices such as mobile phones. OMSI Forum provides such an application which is used to update the software on a phone. Software updates can be done at device management stations placed in stores or other service locations. Whenever a phone's software is updated, information about the update process is stored in a log. These logs can then be analyzed to generate statistics about updates such as the number of successful or failed updates or which faults that are common.</p><p>This master thesis project solves the problem of manually collecting and compiling logs from several stores by making this process automatic. Rather than collecting logs manually, each device management station sends its logs to a centralized server which stores all collected logs in a database. This makes it possible to generate charts and statistics in a simple manner from a web application. This solution makes the analysis more e ective, allowing users to concentrate on analyzing data by removing the work task of collecting logs.</p>
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Sabino, Danilo Damasceno. "Development of a 3D multi-camera measurement system based on image stitching techniques applied for dynamic measurements of large structures." Ilha Solteira, 2018. http://hdl.handle.net/11449/157103.

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Orientador: João Antonio Pereira<br>Resumo: O objetivo específico deste trabalho é estender as capacidades da técnica de rastreamento de pontos em 3 dimensões (three-dimensional point tracking – 3DPT) para identificar as características dinâmicas de estruturas grandes e complexas, tais como pás de turbina eólica. Um sistema multi-camera (composto de múltiplos sistemas de estéreo visão calibrados independentemente) é desenvolvido para obter alta resolução espacial de pontos discretos a partir de medidas de deslocamento sobre grandes áreas. Uma proposta de técnica de costura é apresentada e empregada para executar o alinhamento de duas nuvens de pontos, obtidas com a técnica 3DPT, de uma estrutura sob excitação dinâmica. Três diferentes algoritmos de registro de nuvens de pontos são propostos para executar a junção das nuvens de pontos de cada sistema estéreo, análise de componentes principais (Principal Component Analysis - PCA), decomposição de valores singulares (Singular value Decomposition - SVD) e ponto mais próximo iterativo (Iterative Closest Point - ICP). Além disso, análise modal operacional em conjunto com o sistema de medição multi-camera e as técnicas de registro de nuvens de pontos são usadas para determinar a viabilidade de usar medidas ópticas (e.g. three-dimensional point tracking – 3DPT) para estimar os parâmetros modais de uma pá de gerador eólico comparando seus resultados com técnicas de medição mais convencionais.<br>Abstract: The specific objective of this research is to extend the capabilities of three-dimensional (3D) Point Tracking (PT) to identify the dynamic characteristics of large and complex structures, such as utility-scale wind turbine blades. A multi-camera system (composed of multiple independently calibrated stereovision systems) is developed to obtain high spatial resolution of discrete points from displacement measurement over very large areas. A proposal of stitching techniques is presented and employed to perform the alignment of two point clouds, obtained with 3DPT measurement, of a structure under dynamic excitation. The point cloud registration techniques are exploited as a technique for dynamic measuring (displacement) of large structures with high spatial resolution of the model. Three different image registration algorithms are proposed to perform the junction of the points clouds of each stereo system, Principal Component Analysis (PCA), Singular value Decomposition (SVD) and Iterative Closest Point (ICP). Furthermore, operational modal analysis in conjunction with the multi-camera measurement system and registration techniques are used to determine the feasibility of using optical measurements (e.g. three-dimensional point tracking (3DPT)) to estimate the modal parameters of a utility-scale wind turbine blade by comparing with traditional techniques.<br>Doutor
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Rodríguez, Sánchez Fernando. "Impact of technology readiness in the development of automotive systems when incorporating new styling : a graph theory approach to OPM hierarchical decomposition of the system's architecture." Thesis, Massachusetts Institute of Technology, 2014. http://hdl.handle.net/1721.1/107345.

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Thesis: S.M. in Engineering and Management, Massachusetts Institute of Technology, School of Engineering, Institute for Data, Systems, and Society, System Design and Management Program, 2014.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references (page 55).<br>This thesis addresses to find whether technology readiness, while developing a system of new derivative vehicles, has an influence on the time required to design a part that involves styling and engineering activities. For doing so Styling Level and Technology Readiness were identified as independent variables, whereas Styling Iterations and Styling Iterations Time were designated as the dependent variables. In this case, the tools used to confirm correlation among variables were simple and multiple linear regressions. As it will be further detailed, Styling Iterations Time had the highest response to Technology Readiness while the rest of variables had no significant correlation on time duration for Studio and Engineering design activities. Based on hypothesis results and using OPM hierarchical decomposition, relations between processes and objects were analyzed at a given design state in order to evaluate complete matching relying on bipartite graphs and Hall's Marriage theorem. In addition, it was outlined how to identify delayed processes that fail to coexist due to a low technology readiness at a given design state using the Four-Colour theorem and elaborating about the application of chromatic number and polynomials to the OPM system's architecture. The system of interest was the headlamps system developed under Ford Global Product Development System (GPDS) using the Global Exterior Lighting Plan (PDP).<br>by Fernando Rodríguez Sánchez.<br>S.M. in Engineering and Management
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Ivanov, Ivan [Verfasser], Burkhard [Akademischer Betreuer] Corves, and Lena [Akademischer Betreuer] Zentner. "Methodical development of a parallel kinematic positioning system based on monolithic structures with flexure hinges / Ivan Ivanov ; Burkhard Corves, Lena Zentner." Aachen : Universitätsbibliothek der RWTH Aachen, 2016. http://d-nb.info/1130871592/34.

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Howlader, Md Omar Faruq. "Development of a wall climbing robot and ground penetrating radar system for non-destructive testing of vertical safety critical concrete structures." Thesis, London South Bank University, 2016. http://researchopen.lsbu.ac.uk/1798/.

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This research aims to develop a unique adhesion mechanism for wall climbing robot to automate the technology of non-destructive testing (NDT) of large safety critical reinforced concrete structures such as nuclear power plants, bridge columns, dams etc. This research work investigates the effect of key design parameters involved in optimizing the adhesion force achieved from rare earth neodymium magnets. In order to penetrate a nominal concrete cover to achieve magnetic coupling with buried rebar and generate high enough adhesion force by using minimum number of permanent magnets, criteria such as distance between multiple magnets, thickness of flux concentrator are evaluated by implementing finite element analysis (FEA). The proposed adhesion module consists of three N42 grade neodymium magnets arranged in a unique arrangement on a flux concentrator called yoke. The preliminary FEA results suggest that, using two yoke modules with minimum distance between them generate 82 N higher adhesion force compared to a single module system with higher forceto-weight ratio of 4.36. Presence of multiple rebars in a dense mesh setting can assist the adhesion module to concentrate the magnetic flux along separate rebars. This extended concentration area has led to higher adhesion force of 135.73 N as well as enabling the robot to take turns. Results suggest that, having a 50×50 mm rebar meshing can sustain steep robot rotational movement along it’s centre of gravity where the adhesion force can fall as low as 150 N. A small, mobile prototype robot with on-board force sensor is built that exhibited 3600 of manoeuvrability on a 50×50 mm meshed rebars test rig with maximum adhesion force of 108 N at 35 mm air gap. Both experiment and simulationresults prove that the magnetic adhesion mechanism can generate efficient adhesion force for the climbing robot to operate on vertical reinforced concrete structures. In terms of the NDT sensor, an in-depth analysis of the ground penetrating radar (GPR) is carried out to develop a low cost operational laboratory prototype. A one-dimensional numerical framework based on finite difference time domain (FDTD) method is developed to model response behaviour of a GPR. The effects of electrical properties such as dielectric constant, conductivity of the media are evaluated. A Gaussian shaped pulse is used as source which propagates through the 1D array grid, and the pulse interactions at different media interfaces are investigated. A real life application of GPR to detect a buried steel bar in 1 m thick concrete block is modelled, and the results present 100% accurate detection of the steel bar along with measured depth of the concrete cover. The developed framework could be implemented to model multi-layer dielectric blocks with detection capability of various buried objects. Experimental models are built by utilizing a proposed antenna miniaturization technique of dipole antenna with additional radiating arms. The resultant reflection coefficient values indicate a reduction of 55% and 44% in length reduction compared to a conventional 100 MHz and 200 MHz dipole antenna respectively. The GPR transmitting pulse generator features an enhanced tuneable feature to make the GPR system more adaptable to various environmental conditions. The prototype pulse generator circuit can produce pulses with variable width from 750 ps to 10 ns. The final assembled robotic GPR system’s performance is validated by its capability of detecting and localizing an aluminium sheet and a rebar of 12 mm diameter buried under a test rig built of wood to mimic the concrete structure environment. The final calculations reveal a depth error of +0.1 m. However, the key focus of this work is to prove the design concept and the error in measurement can be addressed by utilizing narrower bandwidth pulse that the proposed pulse generator is capable of generating. In general, the proposed robotic GPR system developed in this research proves the concept of feasibility of undertaking inspection procedure on large concrete structures in hazardous environments that may not be accessible to human inspectors.
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Das, S. C. "Zinc rich paint as anode system for cathodic protection (CP) of reinforced concrete structures and development of corrosion/CP monitoring probes." Thesis, Coventry University, 2012. http://curve.coventry.ac.uk/open/items/5f6b4228-1557-4cf8-bebd-97b5b70bb594/1.

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Since mid-80‟s cathodic protection (CP) has been recognised as the „‟only technique known to stop corrosion regardless of the levels of chloride contamination in concrete‟‟ (FHWA, 1982) and is proved to be the most cost effective means to extend the useful life of the structure. Cathodic protection is an electrochemical technique to stop/mitigate corrosion by supplying „current‟ from an external source in order to suppress the „internally generated‟ current flow due to corrosion processes. The „external‟ current source could be obtained simply by coupling the steel to another electrochemically more active metal, e.g. zinc; alternatively the „external‟ current may be derived from a mains operated low voltage DC power source, viz. transformer/rectifier unit. These two different approaches to supply „external‟ current to stop corrosion are generically termed as: „Sacrificial Anode Cathodic Protection (SACP)‟ system and „Impressed Current Cathodic Protection (ICCP)‟ system, respectively. Both approaches have proved to be feasible, but the impressed current CP system offers greater flexibility with regard to its ability to provide the necessary current in situations where concrete resistivity is relatively high and variable. The sacrificial anode system is most effective if the concrete resistivity is very low or the anode is placed in a very low resistivity environment such as soil with low resistivity, as the inherent driving voltage is low e.g. the potential difference between zinc and corroding steel in concrete is limited to approximately 0.7 volts. Other contra-distinction between the two approaches are that the design life of the sacrificial anode systems are usually range between 10 -15 years; on the other hand the design life of the ICCP systems could be well in excess of 60+ years ( depending on the type of anode system). Page 2 Following the successful application of first CP system, based on impressed current CP (ICCP), on a bridge deck in California, USA 1973, the technology has advanced significantly, particularly the anode systems (which is the main arbiter of a CP system) to deliver the protection current efficiently providing adequate protection (i.e. meeting the criteria recommended in BS EN ISO 12696: 2012 and other International Standards). Most of the CP installations worldwide are operating in ICCP mode. However, due to the escalating cost of anode systems and associated external power supply as well as monitoring/control units for ICCP installation has led researchers to actively pursue different means of developing low cost anode systems. Researchers have mainly focused on sacrificial anode CP (SACP) systems, as SACP does not require an external power supply and control units, but the drawback to this anode system is that it has a shorter life span (usually 10 -15 years compared to 60+ years for ICCP anodes). This work describes the development of an ICCP anode system design utilising commercially available zinc rich paint (ZRP) as a primary anode material offering an innovative but considerably low cost alternative to currently used materials for ICCP anode systems. It also describes the development of a simple and low cost „multifunctional‟ probe for monitoring the performance of the installed CP system, among other functions, such as LPR measurements, macrocell corrosion current measurement, E-log I tests for assessing the current requirements for CP design. For these functions both laboratory investigations and field trial on real life structure were employed.
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Le, Dong D. "Electrical resistivity as a measure of change of state in substrates: Design, development and validation of a microprocessor-based system." Thesis, University of North Texas, 2009. https://digital.library.unt.edu/ark:/67531/metadc12149/.

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Smart structures are relevant and significant because of their relevance to phenomena such as hazard mitigation, structural health monitoring and energy saving. Electrical resistance could potentially serve as an indicator of structural well-being or damage in the structure. To this end, the development of a microprocessor-based automated resistance measurement system with customized GUI is desired. In this research, a nodal electrical resistance acquisition circuit (NERAC) system was designed. The system hardware interfaces to a laptop, which houses a customized GUI developed using DAQFactory software. Resistance/impedance was measured using DC/AC methods with four-point probes technique, on three substrates. Baseline reading before damage was noted and compared with the resistance measured after damage. The device was calibrated and validated on three different substrates. Resistance measurements were taken from PVDF samples, composite panels and smart concrete. Results conformed to previous work done on these substrates, validating the effective working of the NERAC device.
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VARETTI, SARA. "Study and development of an innovative L-PBF demonstrator and an anti-ice solution based on trabecular structures." Doctoral thesis, Politecnico di Torino, 2020. http://hdl.handle.net/11583/2836780.

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Abou-Kandil, Hisham. "Elaboration de structures de commande hiérarchisées : approches monocritère et multicritères." Paris 6, 1986. http://www.theses.fr/1986PA066074.

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Pour un problème de commande optimale linéaire-quadratique monocritère les lois de commande partiellement en boucle fermée à deux niveaux sont étudiées. Une généralisation des moyens de synthèse de ces lois est proposée. Pour les problèmes multicritères linéaires-quadratiques, l'utilisation des stratégies de Nash et de Stackelberg nécessite la résolution d'un ensemble d'équations matricielles couplées. La solution analytique exacte de tous les jeux de Stackelberg en boucle ouverte et d'une large classe des jeux de Nash est obtenue. Ces résultats s'appuient sur les propriétés des spectres des matrices caractérisant les conditions nécessaires à satisfaire par les différentes stratégies.
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Alexa, Kristen M. "Endoderm Patterning in Zebrafish: Pancreas Development: A Dissertation." eScholarship@UMMS, 2009. https://escholarship.umassmed.edu/gsbs_diss/450.

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The pancreas is located below the liver and adjacent to the small intestine where it connects to the duodenum. It consists of exocrine and endocrine components. The exocrine portion makes enzymes which are deposited in the duodenum to digest fats, proteins, and carbohydrates. Exocrine tissue also makes bicarbonates that neutralize stomach acids. The endocrine portion produces hormones such as insulin and glucagon which are released into the blood stream. These hormones regulate glucose transport into the body's cells and are crucial for energy production. The pancreas is associated with diseases such as cancer, diabetes, Annular pancreas and Nesidioblastosis. Annular pancreas and Nesidioblastosis are congenital malformations associated with excess endocrine tissue of the pancreas and its structures. Understanding the development of the pancreas might lead to insight of these diseases. The pancreas arises from the endoderm. In zebrafish, Nodal signaling activates mix-type and gata genes that then function together to regulate sox32 expression which is necessary and sufficient to induce endoderm formation. Interestingly, sox32 is exclusive to zebrafish and works synergistically with pou5f1 to regulate its own expression and turn on sox17 expression. sox17is evolutionarily conserved from zebrafish to mouse and is necessary for endoderm formation. Signals from within the endoderm and the surrounding mesoderm specify regions in the endoderm to develop into the pancreas and other endodermal organs. Sonic hedgehog (shh) expression in the foregut establishes the anterior boundary of the pancreas primordium while cdx4 expression establishes the posterior boundary, but what regulates these factors is unclear. We determined that two Three Amino Acid Loop Extension (TALE) homeodomain transcription cofactors, Meis3 and Pbx4, regulate shh expression in the anterior endoderm. Disrupting either meis3 or pbx4 reduces shh expression in the anterior endoderm. As a result, anterior ectopic insulin expression occurs outside the normal pancreatic domain. Therefore, we discovered upstream regulatory factors of shhexpression in the anterior endoderm, which is necessary for patterning the endoderm and pancreas primordium. We performed an ENU (N-ethyl-N-nitrosurea) haploid screen to look for endocrine pancreas mutants and to find other factors involved in pancreas development and patterning. From the screen, we characterized two mutants. We identified an aldh1a2 mutant, aldh1a2um22, which blocks the production of Retinoic Acid (RA) from vitamin A. While RA is known to be necessary for differentiation of the pancreas and liver, we also found it to be necessary for intestine differentiation. Two other aldh family genes exist in the zebrafish genome, but our data suggests that aldh1a2is the only Aldh that functions in endoderm differentiation and it is maternally deposited. From the screen, we discovered a second mutant, 835.4, that spontaneously arose within the background. pou5f1 expression is normal in mutant embryos, but sox32 expression is reduced and sox17 expression is lost. Downstream endoderm genes of sox17 are also lost and as a result no endodermal organs develop. Rescue experiments indicate that the mutation is located between sox32 and sox17 in the endoderm pathway. We currently have not been successful at mapping this mutation and therefore are unable to rule out the possibility that it lies in the sox17 gene. However, our data suggest that the mutation occurs in a new gene that is necessary for sox17 expression, potentially working with sox32 and/or pou5f1.
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Warsal, Daisy. "The impact of culture on women's leadership in Vanuatu secondary schools." The University of Waikato, 2009. http://hdl.handle.net/10289/2776.

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The government of Vanuatu ratified the Convention on the Elimination of all forms of Discrimination Against Women (CEDAW) in 1995. Following the ratification, Gender Equity in Education Policy was developed in 2005 by the Ministry of Education of Vanuatu. One of the objectives was to increase the number of women principals. However, recent statistics on women in educational leadership in Vanuatu show a decline in the number of women principals. The low percentage of women in educational leadership in the secondary schools of Vanuatu indicates that gender equity in educational leadership is still far from being achieved. This study looks at how Vanuatu culture affects women's leadership in secondary schools and identifies ways in which women's leadership might be developed. Qualitative methods were employed to study the experiences of six women leaders and five aspiring women leaders in several Vanuatu secondary schools. The findings from the study indicate three main areas inherent in Vanuatu culture that significantly impact upon the leadership practices of the participants. The findings reveal the existence of entrenched cultural barriers in the education system, in the social structures of Vanuatu and in the attitudes of individual men, women and some students towards women leaders. These barriers, it seems, are the major impediments to women's advancement in educational leadership in Vanuatu secondary schools.
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Zaini, Raafat Mahmoud. "Modeling Manifest and Latent Structures in a University: Understanding Resources and Dissent Dynamics." Digital WPI, 2017. https://digitalcommons.wpi.edu/etd-dissertations/435.

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Using modeling and computer simulation, this research focuses on studying two different views to organizational design and their implications for performance in the context of academic institutions. One view represents the manifest structure that includes resources (students, faculty, administration, facilities, finances, partners, donors, etc.); the other view represents the latent structure that focuses on dissent. The dissertation addresses the following two questions; 1. What are the tangible dynamic interdependencies constituting the manifest structure within academic institutions and their impact on performance? 2. What is the impact of the latent structures composed of intangible organizational processes, especially dissent, on performance? The dissertation proposes generic system dynamics simulation models untangling the complexity of the topic by tackling various slices of the problem in separate papers. The models are based on three different theoretical frameworks addressing resources and their composition, dissent, and stakeholder engagement. It is observed that while both the manifest and the latent parts of the university organization impact its performance, the latent part, being invisible, is often ignored. In the long run, the influence of the latent part of the organization can slowly but seriously compromise intangible performances components like quality, reputation, and attractiveness. When the manifest part of the organization is dysfunctional, its tangible performance rapidly suffers. The damage control policies will often impact the latent organizational performance leading the institution into a vicious cycle. The presence of time delays in this framework may create an oscillatory behavior that might modulate a growth or decline trend. Performance measures addressing intangible performance components must be factored into the organizational design since faculty, students, and other stakeholders are not only driven by financial rewards, but also by the organizational environment. The research, besides addressing the important question of the role of latent elements in organization design and demonstrating this can be done using system dynamics modeling and computer simulation, should also be of value to the design and management of higher education institutions.
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Henriksen, Eva. "Understanding in Healthcare Organisations- a prerequisite for development." Doctoral thesis, Uppsala University, Department of Public Health and Caring Sciences, 2002. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3072.

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<p>This study proposes that poor understanding of the structures, processes and outcomes of organisations seriously hampers collaboration between professional groups in care organisations. Three care settings were investigated: follow-up of patients with heart disease, an intensive care unit and care services for older people.</p><p>The overall aim was to investigate how people understand structures, processes and outcomes in care organisations. The participants were patients, patient representatives, healthcare professionals, managers and politicians.</p><p>A qualitative approach was used. Thematic analysis and grounded theory were employed in analysing the data.</p><p>Despite considerable efforts, no major changes took place over a 7-year period as to how cardiac follow-up services were understood. The system of cardiac follow-up services was found fragmented in its organisation and in the way individuals understood it. The results indicate that care professionals, patients and leaders have dissimilar understandings. The data suggest that care is organised from a professional-centred perspective rather than from a holistic worldview of the patients’ total context. Leaders in intensive care perceive their organisation as a learning organisation. However, in daily work healthcare tends to function to what can be described as a mass production approach to care. This state of conflict caused confusion and chaos among the leaders. The municipal elderly care services and the county council’s geriatric organisation had difficulties in co-ordination. Older people were perceived as passive recipients of healthcare, rather than as consumers whose well being and outcome were a reflection to the quality of the service.</p><p>The study concludes that despite the major changes that have taken place in the Swedish health and elderly care organisations over the past years, healthcare professionals’ understanding of their work has gone largely unchanged. Their understanding of care structures and processes did not change despite outside pressures. Lack of understanding of what others understand hampers development with the result that care organisations risk stagnation.</p>
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Roy, Nicole Marie. "Regulation of Zebrafish Hindbrain Development by Fibroblast Growth Factor and Retinoic Acid: A Dissertation." eScholarship@UMMS, 2003. https://escholarship.umassmed.edu/gsbs_diss/128.

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Fibroblast growth factor (Fgf) and Retinoic acid (RA) are known to be involved in patterning the posterior embryo. Work has shown that Fgf can convert anterior tissue into posterior fates and that embryos deficient in Fgf signaling lack posterior trunk and tail structures. Likewise, studies performed on RA have shown that overexpression of RA posteriorizes anterior tissue, while disrupting RA signaling yields a loss of posterior fates. While it appears these signals are necessary for posterior development, the role Fgf and RA play in development of the hindbrain is still enigmatic. A detailed study of the requirements for Fgf and RA in the early vertebrate hindbrain are lacking, namely due to a deficiency in gene markers for the presumptive hindbrain at early developmental stages. In this study, we make use of recently isolated genes, which are expressed in the presumptive hindbrain region at early developmental stages, to explore Fgf and RA regulation of the early vertebrate hindprain. We employed both overexpression and loss of function approaches to explore the role of Fgf in early vertebrate development with an emphasis on the presumptive hindbrain region in zebrafish embryos. By loss of function analysis, we show that Fgf regulates genes expressed exclusively in the hindbrain region (meis3 and hoxbla) as well as genes whose expression domains encompass both the hindbrain and more caudal regions (nlz and hoxb1b), thus demonstrating a requirement for Fgf signaling throughout the anteroposterior axis of the hindbrain (rostral to caudal hindbrain) by mid-gastrula stages. To further characterize early gene regulation by Fgf, we utilized an in vitro system and found that Fgf is sufficient to induce nlz directly and hoxb1b indirectly, while it does not induce meis3 or hoxb1a. Furthermore, in vivo work demonstrates that Fgf soaked beads can induce nlz and hoxb1b adjacent to the bead and meis3at a distance. Given the regulation of these genes in vitro and in vivo by Fgf and their position along the rostrocaudal axis of the embryo, our results suggest an early acting Fgf resides in the caudal end of the embryo and signals at a distance to the hindbrain. We detect a similar regulation of hindbrain genes by RA at gastrula stages as well, suggesting that both factors are essential for early hindbrain development. Interestingly however, we find that the relationship between Fgf and RA is dynamic throughout development. Both signals are required at gastrula stages as disruption of either pathway alone disrupts hindbrain gene expression, but a simultaneous disruption of both pathways at later stages is required to disrupt the hindbrain. We suggest that Fgf and RA are present in limiting concentrations at gastrula stages, such that both factors are required for gene expression or that one factor is necessary for activation of the other. Our results also reveal a changing and dynamic relationship between Fgf and RA in the regulation of the zebrafish hindbrain, suggesting that at segmentation stages, Fgf and RA may no longer be limiting or that they are no longer interdependent. As we have demonstrated that an early Fgf signal is required for gastrula stage hindbrain development, we next questioned which Fgf performed this function. We have demonstrated that the early Fgf signal required for hindbrain development is not Fgf3 or Fgf8, two Fgfs known to be involved in signaling centers at the mid-hindbrain boundary (MHB) and rhombomere (r) 4. We further show that two recently identified Fgfs, Fgf4 and Fgf24 are also insufficient alone or in combination with other known Fgfs to regulate hindbrain gene expression. However, as Fgfs may act combinatorially, we do not rule out the possibility of their involvement in early hindbrain gene regulation. However, as time passes and additional Fgfs are isolated and cloned, the elusive Fgf signal required for early hindbrain development will likely be identified. Taken together, we propose that an early acting Fgf residing in the caudal end of the embryo regulates hindbrain genes together with RA at gastrula stages. We suggest that both Fgf and RA are required for gene expression at gastrula stages, but this requirements changes over time as Fgf and RA become redundant. We also demonstrate that the Fgf required for gastrula stage hindbrain development has yet to be identified.
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43

Su, Vivian F. "Quantitative Analysis of Hedgehog Gradient Formation Using an Inducible Expression System: a Dissertation." eScholarship@UMMS, 2006. https://escholarship.umassmed.edu/gsbs_diss/304.

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The Hedgehog (Hh) family of proteins are secreted growth factors that play an essential role in the embryonic development of all organisms and the main components in the pathway are conserved from insects to humans. These proteins affect patterning and morphogenesis of multiple tissues. Therefore, mutations in the Hh pathway can result in a wide range of developmental defects and oncogenic diseases. Because the main components in the pathway are conserved from insects to humans, Drosophilahas been shown to provide a genetically tractable system to gain insight into the processes that Hh is involved in. In this study, the roles of Hh cholesterol modification and endocytosis during gradient fonnation are explored in the Drosophila larval wing imaginal disc. To exclude the possibility of looking at a redistribution of preexisting Hh instead of Hh movement, a spatially and temporally regulated system has been developed to induce Hh expression. Functional Hh-GFP with and without the cholesterol-modification was expressed in a wild-type or shi-tslendocytosis mutant background. The Gal80 system was used to temporally express (pulse) the Hh-GFP transgenes to look at the rate of Hh gradient formation over time and determine whether this process was affected by cholesterol modification and/or endocytosis. Hh with and without cholesterol were both largely detected in punctate structures and the spreading of the different forms of Hh was quantified by measuring distances of these particles from the expressing cells. Hh without cholesterol showed a greater range of distribution, but a lower percentage of particles near the source. Loss of endocytosis blocked formation of intracellular Hh particles, but did not dramatically alter its movement to target cells. Staining for Hh, its receptor Ptc and cortical actin revealed that these punctate structures could be classified into four types of Hh containing particles: cytoplasmic with and without Ptc, and cell surface with and without Ptc. Cholesterol is specifically required for the formation of cytoplasmic particles lacking Ptc. While previous studies have shown discrepancies in the localization of Hh following a block in endocytosis, Hh with and without cholesterol is detected at both apical and basolateral surfaces, but not at basal surfaces. In the absence of cholesterol and endocytosis, Hh particles can be observed in the extracellular space. Through three-dimensional reconstruction and quantitative analysis, this study concludes that the cholesterol modification is required to restrict Hh movement. In addition, the cholesterol modification promotes Ptc-independent internalization. This study also observes that Dynamin-dependent endocytosis is necessary for internalization but does not play an essential role in Hh distribution. The data in this thesis supports the model in which Hh movement occurs via planar diffusion.
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44

Choi, Olivia J. "Spag17 Deficiency Impairs Neuronal Cell Differentiation in Developing Brain." VCU Scholars Compass, 2019. https://scholarscompass.vcu.edu/etd/5877.

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The development of the nervous system is a multi-level, time-sensitive process that relies heavily on cell differentiation. However, the molecular mechanisms that control brain development remain poorly understood. We generated a knockout (KO) mouse for the cilia associated gene Spag17. These animals develop hydrocephalus and enlarged ventricles consistent with the role of Spag17 in the motility of ependymal cilia. However, other phenotypes that cannot be explained by this role were also present. Recently, a mutation in Spag17 has been associated with brain malformations and severe intellectual disability in humans. Therefore, we hypothesized that Spag17 plays a crucial role in nervous system development. To investigate this possibility, we first characterized the spatiotemporal expression of Spag17 in the developing brain by using Beta-galactosidase staining and immunohistochemistry. Results showed Spag17 expression in the spinal cord in embryonic E11. By E11.5-12.5 the expression extends to the rhombic lip from the developing hindbrain, as well as to the forebrain and midbrain regions. E14.5-15.5 embryos exhibit an intense expression in the developing ventricles as well as the cerebellum. From E17.5 to birth (P0), the gene is more broadly expressed. We then used a global Spag17 KO mouse model to characterize the function of Spag17 during brain development. Immunohistochemical studies performed in brain sections from E15.5 and P0 time points showed increased expression of the neural progenitor marker Nestin, and reduced expression of mature neuron marker NeuN, increasing positive trend with the young neuron marker Tuj1. Altogether, these findings reveal that Spag17 has a unique spatiotemporal distribution and may be critical for the maturation of neural progenitor cells.
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45

Sundberg, Björn. "Patriarchy and Masculinity in Doris Lessing's The Fifth Child and in Ben in the World." Thesis, Högskolan i Gävle, Avdelningen för humaniora, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:hig:diva-8471.

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The English novelist, Doris Lessing elucidates the rigidity of a society, which is based upon patriarchy, in her novels, The Fifth Child and Ben in the World. This essay illustrates the causes and the effects of a patriarchal system in the light of feminist ideology supported by Freud’s theories about the acquisition of gender roles. The analysis in this essay of patriarchy and masculinity shows that the novels’ societies as a whole, as well as their criminal subcultures are upheld by people who hold prejudice against others, who do not fit in society’s normal structures, believe in authoritarian social systems and prefer rational solutions to decisions for reasons of conscience. Lessing depicts the complexity of the social relations between characters of different social classes and their relations to society’s institutions. Her unprejudiced penetration into the minds of society’s marginalized people and into the minds of those who represent the oppressive established society illuminates different sides of patriarchy. Lessing gives us to understand that it is extremely difficult, from a moral point of view, to distinguish the established society from its criminal subcultures or society’s oppressors from its victims. Society’s accepted gender roles in the patriarchal system are often ironically described in these novels, certainly with the aim of making us question normative manners, habits and attitudes.
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46

Tillet, Yves. "Les monoamines de l'encephale du mouton (ovis aries) : etude immunocytochimique de la microanatomie et de l'ontogenese des structures concernees." Paris 6, 1986. http://www.theses.fr/1986PA066580.

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L'utilisation d'antiserums reconnaissant la serotonine et les enzymes de synthese des catecholamines a permis la mise en evidence, par immunocytochimie, des structures serotoninergiques et catecholaminergiques dans le snc du mouton. Des investigations identiques faites chez le foetus ont permis de montrer une apparition tres precoce de ces amines dans le snc. Le developpement des structures serotoninergiques est precoce et rapide, plus que celui des structures catecholaminergiques
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47

"Hierarchical Manipulation for Constructing Free Standing Structures." Master's thesis, 2019. http://hdl.handle.net/2286/R.I.55628.

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abstract: In order for a robot to solve complex tasks in real world, it needs to compute discrete, high-level strategies that can be translated into continuous movement trajectories. These problems become increasingly difficult with increasing numbers of objects and domain constraints, as well as with the increasing degrees of freedom of robotic manipulator arms. The first part of this thesis develops and investigates new methods for addressing these problems through hierarchical task and motion planning for manipulation with a focus on autonomous construction of free-standing structures using precision-cut planks. These planks can be arranged in various orientations to design complex structures; reliably and autonomously building such structures from scratch is computationally intractable due to the long planning horizon and the infinite branching factor of possible grasps and placements that the robot could make. An abstract representation is developed for this class of problems and show how pose generators can be used to autonomously compute feasible robot motion plans for constructing a given structure. The approach was evaluated through simulation and on a real ABB YuMi robot. Results show that hierarchical algorithms for planning can effectively overcome the computational barriers to solving such problems. The second part of this thesis proposes a deep learning-based algorithm to identify critical regions for motion planning. Further investigation is done whether these learned critical regions can be translated to learn high-level landmark actions for automated planning.<br>Dissertation/Thesis<br>Masters Thesis Computer Science 2019
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48

Chang, Chao Ming, and 張堯銘. "Development of a Hierarchical Control Model for Flexible Manufacturing System." Thesis, 1995. http://ndltd.ncl.edu.tw/handle/18035928969916229824.

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49

Hus, Ming-Tsan, and 許明燦. "Development of Intelligent System for Hierarchical Searching of Research Materials." Thesis, 2006. http://ndltd.ncl.edu.tw/handle/05572927892810106761.

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碩士<br>華梵大學<br>工業管理學系碩士班<br>94<br>This paper focuses on the problem of developing an intelligent system of hierarchical searching for research materials, which can be done by an intelligent searching method and document classifier. The system considers searching objects that scattered in the Internet and then the searching outcomes automatically generate a well organized report with hierarchical classifications when the searching is complete. For the practicality of searching results, an indexing mechanism and a synonym database from research fields are formed before material searching. Then searching is done among related research sites. Finally, Lightweight Document Clustering approach is applied into these information, gathered from the intelligent search engine, to have the hierarchically organized reports. The proposed system is processed by following steps. First of all, the system fetches the related information from indexing and synonym database in order to perform the intelligent searching. Secondly, a Spider/Crawler retrieves information from Internet based on the information, which is found at the first stage, and related research sites. Thirdly, an intelligent document clustering is applied to form the hierarchical classification of documents. Finally, a feedback system is developed in order to update the indexing database in real time based on the outcomes of document clustering. Following the algorithm, a set of computer programs and a web site was developed. The performance of proposed system is evaluated by the accuracy of searching results, which means searching results matches exactly what users want. From the simulation results, the proposed method is shown as a highly efficient information-filter. And the representation of hierarchical documents based on clustering is really practical method to present the searching results.
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50

Wu, Pei-Jheng, and 吳佩錚. "The Development of Simulation-Based Learning System for Tree Structures of Data Structures." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/v45m3f.

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碩士<br>臺北市立大學<br>資訊科學系<br>104<br>Tree structures are very important concepts in data structure, but their abstract concepts with multiple categories and complex properties are difficult for the learners. The simulation-based learning providing concrete and interactive environment have the potential for reducing the learning problems in tree structures. As a result, the main purpose of this study is to develop a Simulation-Based Learning System (SBLST) for supporting the undergraduate students to learn tree structures of data structure. SBLST offers animation learning and test environment, and the animation environment consists of property illustration mode and step learning mode. In addition, SBLST adopts ICDE learning cycle for helping learners to learn tree structures systematically. After finished the development of SBLST, the study invite 40 ICT experts to evaluate system functions for improving the SBLST. Eventually, this study conducted a self-regulated learning experiment, the samples were 99 undergraduate students, quasi-experimental design method was employed for exploring the learning effectiveness of the SBLST. After class, the experimental group accept self-regulated learning with SBLST, while the control group accept traditional self-regulated learning with textbook. The research period lasted for six weeks. At the end of the experiment, these two groups took the paper-based test of tree structures, and independent sample t-test is used for assessing the learning effect. In addition, the experimental group was asked to fill out the questionnaire for evaluating the system. The research results are shown as follows: 1. The learning achievement in the experiment group was significantly better than that in the control group. 2. The evaluation results show that the learners gave high appraisal toward the system functions including easy to use, useful to use, fun to use and willing to use.
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