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Rozprawy doktorskie na temat „Differentiated thyroid cancers”

Autor: Grafiati

Data publikacji: 7 grudnia 2024

Data aktualizacji: 31 lipca 2025

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1

Sheremet, M. I. "Differential diagnosis of nodular goiter on the background autoimmune thyroiditis and differentiated thyroid cancers." Thesis, БДМУ, 2022. http://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/19664.

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Leboulleux, Sophie. "Place de l'iode 131 et de l'imagerie scintigraphique dans la prise en charge des cancers différenciés de la thyroïde." Thesis, Paris 11, 2013. http://www.theses.fr/2013PA11T062.

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Le traitement initial des cancers différenciés de la thyroïde (CTD) consiste en une thyroïdectomie totale suivie, dans de nombreux cas par l’administration d’iode 131. Après thyroïdectomie totale, un traitement par iode 131 est indiqué en fonction des caractéristiques tumorales initiales. Chez les patients à risque élevé de rechute il est recommandé d’administrer une forte activité d’iode 131. Chez les patients à très faible risque il est recommandé de ne pas administrer d’iode 131. Dans le groupe intermédiaire, il a été montré par deux études prospectives multicentriques randomisées (ESTIMABL

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D'Andréa, Grégoire. "Apport de l'intelligence artificielle, de la protéomique et de la métabolomique dans la prise en charge des cancers thyroïdiens différenciés." Electronic Thesis or Diss., Université Côte d'Azur, 2024. http://www.theses.fr/2024COAZ6011.

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Les nodules thyroïdiens (NT) sont fréquents, et seuls 5-10% s'avèrent être cancéreux. La stratégie diagnostique qu'ils imposent est bien codifiée et permet de stratifier leur risque de malignité, mais ne permet toutefois pas de conclure sur la nature des NT dans 20-25% des cas, on parle alors de NT indéterminés (NTI). Cette situation conduit souvent à la réalisation d'une chirurgie diagnostique, retrouvant 66% de NT bénins. L'amélioration du diagnostic de ces NTI reste donc cruciale. Les cancers thyroïdiens différenciés (CDT) sont de très bon pronostic, grâce à des traitements reposant sur la

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Lang, Brian. "Cancer staging for differentiated thyroid carcinoma." Click to view the E-thesis via HKUTO, 2006. http://sunzi.lib.hku.hk/hkuto/record/B36916134.

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Mehrotra, Pallavi. "Molecular characteristics of differentiated thyroid cancer." Thesis, University of Newcastle upon Tyne, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.405074.

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Chow, Sin-ming, and 周倩明. "Differentiated thyroid cancer in Hong Kong." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2007. http://hub.hku.hk/bib/B41290847.

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Lang, Brian, and 梁熊顯. "Cancer staging for differentiated thyroid carcinoma." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2006. http://hub.hku.hk/bib/B36916134.

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Chow, Sin-ming. "Differentiated thyroid cancer in Hong Kong." Click to view the E-thesis via HKUTO, 2007. http://sunzi.lib.hku.hk/hkuto/record/B41290847.

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Ciappuccini, Renaud. "Apport de l'imagerie fonctionnelle par TEMP/TDM et TEP/TDM dans la prise en charge des cancers différenciés de la thyroïde Incremental Value of a Dedicated Head and Neck Acquisition during 18F-FDG PET/CT in Patients with Differentiated Thyroid Cancer Full text links full-text provider logo Actions Favorites Share Page navigation Title & authors Abstract Conflict of interest statement Figures Similar articles Cited by References Related information LinkOut - more resources EJNMMI Res . 2018 Dec 3;8(1):104. doi: 10.1186/s13550-018-0461-x. Optimization of a dedicated protocol using a small-voxel PSF reconstruction for head-and-neck 18 FDG PET/CT imaging in differentiated thyroid cancer 78 Lymph node involvement in head-and-neck and thyroid cancers with digital PET/CT: the impact of ultra-high definition voxels and point-spread function Tumor burden of persistent disease in patients with differentiated thyroid cancer: correlation with postoperative risk-stratification and impact on outcome 133 18F-Fluorocholine PET/CT is a highly sensitive but poorly specific tool for identifying malignancy in thyroid nodules with indeterminate cytology: The Chocolate study PSMA expression in neovasculature of persistent/recurrent differentiated thyroid cancerin the neck: relationship with radioiodine uptake, 18Fluorodeoxyglucose avidity and outcome." Thesis, Normandie, 2020. http://www.theses.fr/2020NORMC424.

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L’imagerie scintigraphique des cancers thyroïdiens différenciés (CTD) présente la particularité d’utiliser deux radiopharmaceutiques, l’iode 131 (131I) et le 18-Fluorodésoxyglucose (18FDG). La fixation de ces traceurs dépend habituellement du degré de différenciation et de l’agressivité de la tumeur. L’objectif de ce travail était d’étudier l’apport de différents aspects techniques et d’instrumentation, à savoir l’imagerie hybride par TEMP/TDM et TEP/TDM, la point-spread function (PSF), la taille des voxels et la technologie TEP digitale, et d’explorer si d’autres traceurs TEP pouvaient présen

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10

Marcelino, Ana Sousa. "Targeting thyroid stimulating hormone receptors in radioiodine resistent de-differentiated thyroid cancer." Thesis, Queen Mary, University of London, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.576914.

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The most common type of thyroid cancer, differentiated thyroid cancer (DTC), is diagnosed by radioactive iodine whole body scanning (WBS) and treated with radiotherapy using iodine-13I C31 I). The success of this diagnosis/treatment approach relies on the relatively selective localisation of the sodium/iodide symporter (NIS) in cells of the thyroid gland. However, in some de-differentiated thyroid cancers, NIS expression is lost. This results in the inability of WBS to stage the disease and it also decreases the effectiveness of treatment with 131 I. A number of reports have shown that de-diff

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11

Lundgren, Catharina Ihre. "Incidence and prognosis of differentiated thyroid cancer in Sweden /." Stockholm, 2006. http://diss.kib.ki.se/2006/91-7140-577-1/.

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Ifad, D. R. Masud. "Radioiodine dosimetry in the management of differentiated thyroid cancer." Thesis, Institute of Cancer Research (University Of London), 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.503095.

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13

Craig, Wendy. "Differentiated thyroid cancer : the rationale for a risk stratified approach to management." Thesis, University of Aberdeen, 2013. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=196011.

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Background: Differentiated thyroid cancer (DTC), although rare, is the commonest endocrine malignancy, with a significant recent increase in incidence. Natural history is well understood: the majority of patients have an extremely good prognosis, but with a tendency for late recurrences, up to twenty years post diagnosis. These features have combined to effect a lack of evidence underlying current practice, the majority of guidelines based around retrospective series and opinion. A number of validated risk stratification systems exist, unique to DTC, some applicable at the point of interventio

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14

Joseph, Kyle Reece. "An Investigation of the Risk Factors of Differentiated Thyroid Cancer by Meta-Analysis." Thesis, The University of Sydney, 2017. http://hdl.handle.net/2123/18686.

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INTRODUCTION: Thyroid cancer is the most common endocrine malignancy and its incidence is increasing, of which the most common subtype is papillary thyroid cancer. Risk factors for papillary thyroid cancer have been investigated extensively. Given the good prognosis of papillary thyroid cancer there is growing concern regarding the development of second primary malignancies following thyroid cancer. This study specifically considered breast cancer is the most common cancer in women and has been theorized to be associated with thyroid cancer under certain conditions. Multifocality is a risk fac

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15

Martins, Mayane Emanuela Melo Lopes. "Immunohistochemical evaluation ESTROGEN RECEPTORS ΑLFA EXPRESSION AND PROGESTERONE in differentiated thyroid cancer." Universidade Federal do CearÃ, 2015. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=16565.

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Conselho Nacional de Desenvolvimento CientÃfico e TecnolÃgico<br>With the use of sensitive imaging methods, there is an increase in thyroid nodules diagnosed. Even the CDT (differentiated thyroid cancer) being proportionately rare, its incidence is increasing, especially small tumors whose clinical outcome is uncertain. It is observed that in clinical practice most patients with CDT develops well when properly treated, mortality rates similar to the general population. On the other hand, a non-negligible percentage has relapses and some eventually not respond to conventional therapies, and die

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16

Chen, Guofang [Verfasser]. "Effect of metformin on growth of differentiated thyroid cells and thyroid carcinoma cells and their derived cancer stem cells : implication for metformin as adjuvant treatment for undifferentiated thyroid cancer / Guofang Chen." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2012. http://d-nb.info/1029792062/34.

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17

Alrasheed, Maha Meshal. "Association of gene polymorphisms in thyroid function-related genes with differentiated thyroid cancer risk and post thyroidectomy l-thyroxine suppressive dose requirements." Thesis, University of Brighton, 2013. https://research.brighton.ac.uk/en/studentTheses/a70cf85d-a940-4ab0-8eff-51c3fb069d2d.

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Patients with differentiated thyroid cancer (DTC) are usually managed with total thyroidectomy and subsequent radioiodine ablation of the remnant thyroid tissue. Since these patients become athyrotic, L-throxine (L-T4) therapy is required for life, in order to replace the thyroid hormones and also to suppress the endogenous thyroid stimulating hormone (TSH) which may have a growth-promoting effect on any residual thyroid cancer cells. The approximate dose required to achieve this suppression is about 2 g/kg. However, there is wide variation between patients in their L-T4 requirement. Although

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18

CROCE, LAURA. "THE COMPLEX RELATIONSHIP BETWEEN CHRONIC INFLAMMATION AND DIFFERENTIATED THYROID CANCER: EVIDENCE FROM IN VITRO AND CLINICAL STUDIES." Doctoral thesis, Università degli studi di Pavia, 2022. http://hdl.handle.net/11571/1463185.

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Inflammation is an essential component of malignancies, including differentiated thyroid cancer (DTC). Thyroid cancer microenvironment is composed of a mixture of immune cells and soluble mediators. Among them, the chemokine CXCL8 exerts multiple pro-tumorigenic activities, including a chemotactic action on circulating neutrophils, induction of tumor cells growth, increase in angiogenesis and induction of the epithelial to mesenchymal transition, which promotes cell migration. Clinical studies in patients affected by several types of cancer evidenced that CXCL8 serum levels reflect the tumor b

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19

Grassi, E. S. "P53 AND MICROTUBULES TARGETING AS A NOVEL STRATEGY WITH POTENTIAL FOR TREATMENT OF AGGRESSIVE POORLY DIFFERENTIATED THYROID CANCER." Doctoral thesis, Università degli Studi di Milano, 2014. http://hdl.handle.net/2434/232400.

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Thyroid cancer is the most common endocrine malignancy and his global incidence has rapidly increased in last decades. Despite the major part of thyroid cancer is represented by well differentiated hystotypes, the acquisition of additional mutations, such as p53 and β-catenin ones, causes loss of differentiation and confer high malignancy. Current treatment for undifferentiated thyroid cancers is regarded as almost ineffective, with a median survival of 3- 4 months, somewhat better in localized and worse in metastatic disease. SP600125 is a multi-kinase inhibitor that has recently been shown

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20

Alam, Md Sayeedul. "Study on Usefulness of ^[99m]Tc-MTBI Scinitigraphy in Detection of Local Recurrence and Metastases from Differentiated Thyroid Cancer." Kyoto University, 1999. http://hdl.handle.net/2433/181711.

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要旨pdfファイル:タイトル「Diagnostic Value of Technetium-99m Isonitrile (^[99m]Tc-MIBI) Scintigraphy in Detecting Thyroid Cancer Metastases : A Critical Evaluation」<br>Kyoto University (京都大学)<br>0048<br>新制・課程博士<br>博士(医学)<br>甲第7742号<br>医博第2095号<br>新制||医||710(附属図書館)<br>UT51-99-G336<br>京都大学大学院医学研究科内科系専攻<br>(主査)教授山邊博彦, 教授高橋隆, 教授小西淳二<br>学位規則第4条第1項該当

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21

Ren, Yan. "L’apport alimentaire en iode, sélénium dans les ongles, et risque du cancer différencié de la thyroïde : analyses d’études cas-témoins du consortium Epi-Thyr." Thesis, Université Paris-Saclay (ComUE), 2017. http://www.theses.fr/2017SACLS120/document.

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Contexte: L’iode est un micronutriment provenant des aliments. Il est établi que, dans les régions d'endémie goitreuse caractérisées par un apport d'iode insuffisant, l’incidence des goitres et des cancers différenciés de la thyroïde (CDT) de type folliculaire est plus élevée qu'ailleurs. En revanche, l’influence de l’apport alimentaire en iode sur le risque de CDT de type papillaire, forme représentant actuellement plus de 80% des CDTs dans la plupart des pays, ne fait pas l’objet d’un consensus. Il semble cependant que cette incidence soit plus élevée dans les îles du pacifique qu’ailleurs.

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Petrocelli, Diego. "Revisão Sistemática e Metanálise da Eficácia da Pesquisa de Corpo Inteiro pré-dose terapêutica com 131I em indivíduos com Carcinoma Diferenciado da Tireoide." Botucatu, 2018. http://hdl.handle.net/11449/155881.

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Orientador: Vania dos Santos Nunes Nogueira<br>Abstract: Although being controversial, some services use Whole Body Imaging (WBI) with 131I prior to the ablative dose with this radiopharmaceutical in the treatment of differentiated thyroid cancers (DTC). Proponents of this approach argue for a better optimization of the ablative dose, and opponents argue that this WBI could lead to the "stunning effect" characterized by reduced tissue uptake of 131I in ablative dose treatment, thereby compromising treatment and prognosis of these individuals. Objective: To evaluate whether WBI with 131I, ablat

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Coelho, Maria João de Gusman Geraldes Correia. "Role of mThor Pathway in Differentiated Thyroid Cancer." Master's thesis, 2015. https://repositorio-aberto.up.pt/handle/10216/81858.

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Coelho, Maria João de Gusman Geraldes Correia. "Role of mThor Pathway in Differentiated Thyroid Cancer." Dissertação, 2015. https://repositorio-aberto.up.pt/handle/10216/81858.

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Yang, Huei-Ping, and 楊蕙萍. "Health Care Needs and Related Factors in Differentiated Thyroid Cancer Patients Post Surgery." Thesis, 2019. http://ndltd.ncl.edu.tw/handle/p3s756.

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碩士<br>國立臺灣大學<br>護理學研究所<br>107<br>The purposes of this study were to (1) explore the level of symptom severity, body image changes, fear cancer recurrence (FCR), and supportive care need; and (2) the relationship between care needs and disease/ treatments and above mentioned factors in Differentiated Thyroid Cancer (DTC) patients within three year post surgery. A cross-sectional design with consecutive sampling was conducted to recruit DTC patients in one medical center in Northern Taiwan. Two research nurses assessed for patients’ Symptom Severity, Body Image, Fear of Cancer Recurrence, (4) S

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Tasevski, Robert. "Management Patterns and Outcomes of Differentiated Thyroid Cancer in Ontario: A Population-based Study." Thesis, 2013. http://hdl.handle.net/1807/35143.

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The incidence of differentiated thyroid cancer (DTC) is rising, but controversy exists in many aspects of its treatment. This study described the change in incidence of DTC in Ontario, variations in management including extent of thyroidectomy and the influence of provider volume, and the impact of these parameters on recurrence and thyroid cancer-specific death (TCSD). A population-based study identified all new cases of DTC between 1992-2007. The incidence of DTC increased dramatically (annual percentage change 7.6%). Linkage to administrative databases revealed that extent of thyroidectomy

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Wu, Che-Wei, and 吳哲維. "Association of Gene Polymorphisms in DNA Base-Excision Repair Pathway with Differentiated Thyroid Cancer." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/88403440826927501376.

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碩士<br>高雄醫學大學<br>醫學研究所碩士班<br>96<br>Objectives/Hypothesis DNA base excision repair (BER) pathway has been shown to be related with carcinogenesis. We hypothesized that functional polymorphisms of five BER genes, hOGG1 (human oxoguanine glycosylase 1), MBD4 (methyl-CpG binding domain protein 4), XRCC1 (X-ray repair cross complementing group 1), APE1 (apurinic/apyrymidinic endonuclease/redox effector-1) and ADPRT (adenosine diphosphate ribosyl transferase) confer a risk for differentiated thyroid carcinoma (DTC) and lymph node (LN) metastasis. Methods In a case–control study of 283 DTC cases an

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Lin, Jen-Chih, and 林荏志. "Tagging single-Nucleotide Polymorphisms in GPX-3 gene and susceptibility to Differentiated Thyroid Cancer." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/00458343512506935649.

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碩士<br>高雄醫學大學<br>醫學研究所碩士班<br>96<br>Introduction: Although the exact etiology of differentiated thyroid cancer (DTC) is not well understood, exposure to radiation is considered as a risk factor. Radiation can cause direct DNA damage and the generation of reactive oxygen species (ROS). In the thyroid, ROS and free radicals can participate in physiological and pathological processes. The antioxidant enzymes such as glutathione peroxidase (GPX), especially GPX3, can lower down the oxidative stress in thyrocyte. We want to find the relationship between the genetic variants of GPX3 and differentiated

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Adedapo, Kayode Solomon. "Adequate duration and modality of follow-up for patients treated with 131 I for differentiated thyroid cancer." Thesis, 2009. http://hdl.handle.net/10539/7454.

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Santos, Luis Filipe de Sepúlveda Silva. "DNA repair SNPs as genetic modulators of individual susceptibility to differentiated thyroid cancer and response to radioiodine therapy." Doctoral thesis, 2021. https://hdl.handle.net/10216/134414.

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Santos, Luis Filipe de Sepúlveda Silva. "DNA repair SNPs as genetic modulators of individual susceptibility to differentiated thyroid cancer and response to radioiodine therapy." Tese, 2021. https://hdl.handle.net/10216/134414.

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Lima, Ana Rita Marçal Dantas de. "Role of the MITOchondrial fission protein DRP1 as a prognosis and predictive biomarker in the treatment of differentiated thyroid cancer (ROMITO-DRP1)." Doctoral thesis, 2021. https://hdl.handle.net/10216/133414.

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Lima, Ana Rita Marçal Dantas de. "Role of the MITOchondrial fission protein DRP1 as a prognosis and predictive biomarker in the treatment of differentiated thyroid cancer (ROMITO-DRP1)." Tese, 2021. https://hdl.handle.net/10216/133414.

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Marotta, Vincenzo. "Molecular predictors of clinical outcome in differentiated thyroid cancer: prognostic significance of germline polymorphisms of VEGF-A, VEGFR-2, and PDGFR-α". Tesi di dottorato, 2016. http://www.fedoa.unina.it/10733/1/marotta_vincenzo_28.pdf.

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Angiogenesis is crucial for cancer progression and its efficiency may affect disease evolution, and therefore clinical outcome. Given that cancer-related vessel formation relies on the host angiogenic machinery, individual genetic variability affecting physiological angiogenesis may impact on cancer prognosis. Function of angiogenesis-regulating genes may be affected from single nucleotide polymorphisms (SNPs) through the modulation of gene-expression. Prognostic stratification of differentiated thyroid cancer (DTC) is still suboptimal as no effective tools are available for identifying

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Oliveira, Luís Ferreira de. "Caso clínico – carcinoma da tireoide refratário ao iodo radioativo." Master's thesis, 2018. http://hdl.handle.net/10316/82652.

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Trabalho Final do Mestrado Integrado em Medicina apresentado à Faculdade de Medicina<br>Introduction: Tyrosine kinase inhibitors (TKI) are the main therapeutic alternative for differentiated thyroid carcinomas refractory to radioiodine (131I), progressive and metastatic. Few data are available on the efficacy and safety of sequentially using a second drug of this class.Clinical case: A patient submitted to total thyroidectomy in 2012 for papillary carcinoma measuring 9 cm, with extrathyroidal extension, venolymphatic invasion, lymph node metastasis (pT3N1bMx;R0;LVI) and neoplastic thromboembos

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Μανωλάκου, Σταυρούλα. "Ο μεταγραφικός παράγων Nrf2 στο διαφοροποιημένο καρκίνωμα του θυρεοειδούς αδένα". Thesis, 2014. http://hdl.handle.net/10889/8166.

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Θεωρητικό υπόβαθρο: Το οξειδωτικό στρες (ΟΣ) ορίζεται ως το παθολογικό αποτέλεσμα που προκύπτει από τη διαταραχή της ισορροπίας των κυτταρικών συγκεντρώσεων των οξειδωτικών, δραστικών ενώσεων και των αντιοξειδωτικών μορίων. Εκτός από τη βλάβη που υπόκεινται οι πρωτεΐνες και τα λιπίδια, το ΟΣ μπορεί επίσης να προκαλέσει μεταλλάξεις και επιγενετικές μεταβολές καταστρέφοντας τόσο το DNA όσο και τις πρωτεΐνες που τροποποιούν τη χρωματίνη. Παρ' όλα αυτά, στα θυρεοειδικά θυλακικά κύτταρα παράγονται σε καθημερινή βάση υψηλές ποσότητες υπεροξειδίου του υδρογόνου (H2O2), οξειδωτικής ουσίας απαραίτητης

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