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Rozprawy doktorskie na temat „Digoxin”

Autor: Grafiati

Data publikacji: 4 czerwca 2021

Data aktualizacji: 25 lipca 2025

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1

Alexandrovich, Susan K. "Characterization of monoclonal antibodies against digoxin /." Online version of thesis, 1987. http://hdl.handle.net/1850/10681.

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Matthewson, Beryl Ellen. "Digoxin-like immunoreactive substances in the neonate." Thesis, University of British Columbia, 1988. http://hdl.handle.net/2429/28022.

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Digoxin, a steroidal glycoside that inhibits Na⁺/K⁺-ATPase, is the most commonly prescribed cardiac medication in North America. Blood levels of this drug are routinely measured to reduce the risks of toxicity. Reports questioning the specificity of antisera used in radioimmunoassays for serum digoxin measurements began to appear after 1975¹ when plasma from patients with renal failure, not on glycoside therapy, showed false-positive digoxin levels. Since then, digoxin-like immunoreactive substances (DLIS) have been found in sera from patients with hepatic failure, hypertension, pre-eclampsia,

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3

Hui, James. "Analysis for digoxin and metabolites in serum and digoxin disposition in the elderly with gastrointestinal disease after two oral dosage forms /." The Ohio State University, 1988. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487587604130428.

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4

Hallberg, Pär. "Pharmacogenomics of antihypertensive treatment & clinical pharmacological studies of digoxin treatment /." Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-5782.

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Cavet, Megan Elizabeth. "Intestinal secretion of organic solutes." Thesis, University of Newcastle Upon Tyne, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.318538.

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6

Svensson, Åsa. "Applications of a new logic to old drugs: angiogenesis inhibition in neuroblastoma /." Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2003. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3458.

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7

BARROS, Isabel Cristina Medeiros. "Monitoração terapêutica das concentrações plásmaticas da digoxina em pacientes com insuficiência cardíaca." Universidade Federal de Goiás, 2008. http://repositorio.bc.ufg.br/tede/handle/tde/1703.

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Made available in DSpace on 2014-07-29T15:29:05Z (GMT). No. of bitstreams: 1 dissertacao isabel cristina.pdf: 549593 bytes, checksum: ff591d0e143ca66263716f60188e9801 (MD5) Previous issue date: 2008-10-27<br>It was investigated the clinical, lab and plasma digoxin concentration profiles in 15 cardiac heart failure (CHF) outpatients of the Cardiac Heart Service of the Goias Federal University Clinical Hospital. It was aimed to know plasma digoxin concentration profile in 15 cardiac heart failure (CHF) outpatients by two analytical methods, taking account clinical, laboratorial, habits, anthro

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8

Embree, Leanne. "Development of a sensitive, quantitative high-performance liquid chromatographic assay for the measurement of digoxin in patient groups with high levels of digoxin-like immunoreactive substances." Thesis, University of British Columbia, 1989. http://hdl.handle.net/2429/29093.

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Digoxin is the most commonly used digitalis glycoside for the treatment of congestive heart failure and certain disturbances of cardiac rhythm. The low therapeutic index observed for digoxin and the clinical significance of digoxin therapy have necessitated the development of sensitive analytical methods for the quantitation of digoxin in biological samples. Digoxin may be analysed by several methods including immunoassays, chromatographic procedures and various biological and chemical methods. Immunoassays, both radioimmunoassay (RIA) and fluorescence polarization immunoassay (FPIA) procedur

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9

Hallberg, Pär. "Pharmacogenomics of Antihypertensive Treatment & Clinical Pharmacological Studies of Digoxin Treatment." Doctoral thesis, Uppsala universitet, Institutionen för medicinska vetenskaper, 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-5782.

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In Part I we found that the CYP2C9 genotype appears to influence the diastolic blood pressure response to the angiotensin II-receptor antagonist irbesartan in patients with hypertension and left ventricular hypertrophy. Those with the *1/*2 genotype (slower metabolism) responded better than those with the *1/*1 genotype (normal metabolism), likely due to a slower elimination of the drug. We further found that a +9/-9 exon 1 polymorphism of the B2 bradykinin receptor gene – shown to affect mRNA expression - appears to influence the regression of left ventricular mass during therapy with irbesar

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10

Vetticaden, Santosh John. "Evaluation of Analytical, Pharmacokinetic and Pharmacodynamic Methods for the Study of Digoxin." VCU Scholars Compass, 1985. http://scholarscompass.vcu.edu/etd/5103.

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The primary objective of the research was to investigate the pharmacodynamics of digoxin in dogs. Initially an assay specific for digoxin in the presence of its major metabolites, viz., digoxigenin, digoxigenin mono-digitoxoside, digoxigenin bis-digitoxoside and dihydrodigoxin was developed using HPLC-RIA. Methodology for non-invasive measurement of left ventricular ejection time (LVET) and other systolic time intervals (STI) in beagle dogs were developed. This involved surgery for exteriorization of the carotid artery in the dogs and subsequent measurements of LVET and STI after recovery. STI

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11

Murata, Viviane Midori. "Produção e caracterização da porção Fab do anticorpo anti-digoxina utilizando a tecnologia de phage display." Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/87/87131/tde-11062012-083314/.

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A digoxina é um medicamento usado para tratar distúrbios cardíacos, com janela terapêutica muito estreita. Para combater seu efeito tóxico, fragmentos Fab do anticorpo policlonal anti-digoxina estão disponíveis comercialmente. Nosso objetivo foi a obtenção de variantes de fragmentos Fab do anticorpo monoclonal anti-digoxina usando a tecnologia phage display, que permite gerar fragmentos de anticorpos de alta afinidade e especificidade. Uma biblioteca combinatória de fragmentos Fab anti-digoxina foi construída no vetor pComb3X a partir do RNA total do hibridoma anti-digoxina. Seis clones foram

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12

Tzou, Meir-Chyun. "Development and validation of a specific high performance liquid chromatographic method for determination of digoxin and metabolites in serum and its applications to digoxin metabolism and therapeutic drug monitoring studies in humans /." The Ohio State University, 1994. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487854314873705.

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13

Baek, Myoungki. "Dynamic system analysis of receptor interaction and effectuation mechanisms of digoxin in the rat heart." [S.l.] : [s.n.], 2005. http://deposit.ddb.de/cgi-bin/dokserv?idn=975656562.

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Weitkamp, Christine. "Warum zeigen die Herzglykoside Ouabain und Digoxin unterschiedliche Kreislaufwirkung? Charakterisierung eines mutmasslichen Herzglykosid-Bindungsproteins im Serum und Analyse der Wirkung beider Steroide auf die Endothelin-1- und NO-Freisetzung aus arteriellen Endothelzellen /." Wettenberg : VVB Laufersweiler, 2005. http://deposit.ddb.de/cgi-bin/dokserv?idn=976405792.

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15

Gashi, Elida. "Hur påverkar johannesört farmakokinetiken utav warfarin, ciklosporin, digoxin, preventivmedel och teofyllin? Vad har detta för klinisk betydelse?" Thesis, Linnéuniversitetet, Institutionen för naturvetenskap, NV, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-18745.

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St. John’s wort extract is composed of a large number of components, about 150, but the most studied and interesting substance are hyperforin and hypericin. The herb is very popular and it is known for its pharmacological efficacy in numerous disorders. It is used for treatment of mild to moderated depression as an alternative to synthetic antidepressants. The St. John’s wort products are available in several preparations, as tablets, capsules, tea, fresh plant juice etc. Hyperforin is the part of St. John’s wort that gives the antidepressant effect through inhibition of reuptake of neurotrans

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16

Inocencio, André Luís. "Purificação e caracterização do fragmento Fab anti-digoxina obtido pela técnica de phage display." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/87/87131/tde-25082016-085639/.

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A digoxina é um dos medicamentos indicados para o tratamento de falência cardíaca. Possui janela terapêutica estreita, sendo responsável por casos de intoxicação. O único antídoto disponível para a desintoxicação é o anticorpo policlonal DigiFab®, no formato Fab. O seu uso é eficaz, porém de custo elevado. Clones bacterianos produtores de fragmento Fab monoclonal anti-digoxina foram obtidos previamente pelo nosso grupo, pela técnica de phage display. Neste trabalho as variantes Fab dos 4 clones foram expressas em E.coli para estabelecer o método para a purificação. Com a obtenção dos fragment

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17

Meseg, Antje [Verfasser]. "Einfluss von Polymorphismen im Multidrug resistance Gen Typ 1 (ABCB1) auf die Single dose Kinetik von Digoxin / Antje Meseg." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2008. http://d-nb.info/1022941127/34.

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18

Hopoate-Sitake, Moana Lee. "A Novel Use of Digoxin Immune Fab Fragment in Identification and Isolation of an Endogenous Digitalis-like Factor Found in Preeclampsia." BYU ScholarsArchive, 2011. https://scholarsarchive.byu.edu/etd/2599.

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The mechanisms mediating the hypertension of preeclampsia (PE) are unclear. Endogenous digitalis-like factors (EDLFs) are specific sodium pump (SP) inhibitors implicated in essential and experimental hypertension, but they have not been fully explored in the setting of PE. This study uses a digoxin antibody Fab fragment to address the question of whether such factors are present and increased in PE, to investigate a possible treatment of PE, and to isolate and characterize all EDLFs present in PE. Sera and placenta from women with PE did show a significant increase in SP inhibition in comparis

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19

Svensson, Åsa. "Application of a New Logic to Old Drugs: Angiogenesis Inhibition in Neuroblastoma." Doctoral thesis, Uppsala University, Department of Medical Cell Biology, 2003. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3458.

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<p>Neuroblastoma is one of the most common solid cancers of early childhood. In Sweden, approximately 10-15 cases occur annually. The overall five-year neuroblastoma survival in Europe is approximately 45%. Since cancer treatment involves drugs with risks of side effects in the growing child, there is a need for more effective and less toxic drugs. One new approach in cancer treatment is inhibition of tumor angiogenesis, i.e., of new blood vessel growth into the tumor. An angiogenesis inhibitor may be combined with cytostatic drugs to enhance the efficacy. The aim of this study was to investig

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20

Ma, Jie. "Human Endogenous Sodium Pump Inhibitors Measurement, Source, Synthesis and Regulation." BYU ScholarsArchive, 2011. https://scholarsarchive.byu.edu/etd/2953.

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The sodium pump (SP or Na+,K+-ATPase) is a membrane embedded protein complex that pumps 3 sodium ions out and 2 potassium ions into the cell per cycle and in so doing creates a cell membrane electrochemical potential. The membrane potential is critical for any functional cell. In the vasculature, reduction in the voltage potential causes vascular smooth muscle contraction and a narrowing of blood vessels (vasoconstriction) which can lead to increased blood pressure (hypertension). Substantial research over the past several decades has provided a vast amount of research on SP inhibitors, someti

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21

Neves, Claodete Hasselstrom. "Efeitos da administração crônica da digoxina e do verapamil sobre o desempenho físico e a estrutura e função cardíaca em ratos submetidos ao treinamento físico intervalado." Universidade Federal de Mato Grosso, 2015. http://ri.ufmt.br/handle/1/682.

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Nguyen, Khoa Thuy Diem. "Energy metabolism in the brain and rapid distribution of glutamate transporter GLAST in astrocytes." Thesis, The University of Sydney, 2008. http://hdl.handle.net/2123/3996.

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Glutamate transporters play a role in removing extracellular excitatory neurotransmitter, L-glutamate into the cells. The rate of the uptake depends on the density of the transporters at the membrane. Some studies claimed that glutamate transporters could transit between the cytoplasm and the membrane on a time-scale of minutes. The present study examined the distribution of glutamate transporter GLAST predominantly expressed in rat cortical cultured astrocytes between the membrane and the cytoplasm by using deconvolution microscopy and then analyzing the images. The regulation of the dist

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Nguyen, Khoa Thuy Diem. "Energy metabolism in the brain and rapid distribution of glutamate transporter GLAST in astrocytes." University of Sydney, 2008. http://hdl.handle.net/2123/3996.

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Doctor of Philosophy (Medicine)<br>Glutamate transporters play a role in removing extracellular excitatory neurotransmitter, L-glutamate into the cells. The rate of the uptake depends on the density of the transporters at the membrane. Some studies claimed that glutamate transporters could transit between the cytoplasm and the membrane on a time-scale of minutes. The present study examined the distribution of glutamate transporter GLAST predominantly expressed in rat cortical cultured astrocytes between the membrane and the cytoplasm by using deconvolution microscopy and then analyzing the

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24

Howard, Cory M. "Characterization of the CXCR4-LASP1-eIF4F Axis in Triple-Negative Breast Cancer." University of Toledo Health Science Campus / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=mco1596298549051863.

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Abarca, Jacob. "The effect of beta-blocker therapy, ACE inhibitor therapy,and digoxin therapy on the risk of hospitalization and resource utilizationamong patients with congestive heart failure enrolled in a managed care organization." Thesis, The University of Arizona, 2001. http://hdl.handle.net/10150/291440.

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Congestive heart failure (CHF) represents the end-stage of all heart disease. The current incidence of CHF in the US is 550,000 cases per year and is expected to increase in the future. Therapy with β-blockers, ACE inhibitors, and digoxin has been associated with a decreased risk of all-cause hospitalization and CHF-related hospitalization in randomized clinical trials. The purpose of this study was to evaluate the effect of beta-blocker, ACE inhibitor, and digoxin therapy on these outcomes and total direct medical costs among patients with CHF enrolled in a managed care plan. Neither therapie

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26

Duan, Qiming. "Cardiac Na/K-ATPase in Ischemia-Reperfusion Injury and Cardioprotection." University of Toledo Health Science Campus / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=mco1388151402.

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ALEMANNI, MATTEO. "The modulation of SERCA pump activity as a tool for management of hearth failure." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2009. http://hdl.handle.net/10281/7462.

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The current positive inotropic interventions for the management of heart failure (HF) are all associated to an unchanged or increased long term mortality, which limit their use. Istaroxime (IST) is a novel positive inotrope able to inhibit Na+, K+ ATPase and to stimulate SERCA pump. We employed IST as a tool to assess the role of a mild SERCA stimulation as a positive inotropic intervention. In a guinea pig model of HF, where the sarcoplasmic reticulum (SR) function was deranged, IST was able to restore an optimal SR function, increase the SR Ca2+ content and to improve all the EC coupling par

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28

Claassen, Marleen. "Exploring the contribution of prenatal stress to the pathogenesis of autism as a neurobiological developmental disorder : a dizygotic twin study." Diss., University of Pretoria, 2006. http://hdl.handle.net/2263/23190.

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This research project explores the contribution of prenatal stress to the pathogenesis of autism as a neurobiological developmental disorder. The neurobiological impact of stress prior to the 28th week of gestation might produce structural neural changes, specifically regarding the cerebellum, the brain stem and limbic pathways, including the hippocampal area, which concept relates closely to the pathogenesis of autism. In this research project a significant focus is placed on prenatal hipothalamic-pituary-adrenal (HPA) activity due to the HPA axis’ interactivity with cortisol, digoxin and ser

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Weitkamp, Christine [Verfasser]. "Warum zeigen die Herzglykoside Ouabain und Digoxin unterschiedliche Kreislaufwirkung? : Charakterisierung eines mutmaßlichen Herzglykosid-Bindungsproteins im Serum und Analyse der Wirkung beider Steroide auf die Endothelin-1- und NO-Freisetzung aus arteriellen Endothelzellen / Christine Weitkamp." Wettenberg : VVB Laufersweiler, 2005. http://d-nb.info/976405792/34.

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HANOT, REGIS. "Tolerance de l'association digoxine - cibenzoline : impact des antiarythmiques sur le traitement par digoxine." Lille 2, 1993. http://www.theses.fr/1993LIL2M037.

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Moriau, Didier. "Aspects pharmacocinétiques de l'interaction digoxine-quinidine/." Paris 5, 1989. http://www.theses.fr/1989PA05P010.

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Boe͏̈l, Frédéric. "Automatisation du prélèvement et du dosage HPLC de l'essai de dissolution des comprimés de digoxine." Paris 5, 1994. http://www.theses.fr/1994PA05P189.

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MOLINARI, BENOIT PATRICIA. "La digoxine chez le sujet age : interet du dosage de la digoxinemie ; application pratique." Toulouse 3, 1992. http://www.theses.fr/1992TOU31089.

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CANO, CANO NATHALIE. "Evaluation de l'immunoreactivite d'anticorps anti-digoxine en immunotoxicotherapie." Paris 6, 1993. http://www.theses.fr/1993PA066706.

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L'immunotoxicotherapie repose sur l'administration d'anticorps ou de fragments specifiques d'un toxique. L'objectif de notre etude a ete d'evaluer l'influence des caracteristiques d'un anticorps (affinite et dose) sur son potentiel de detoxication. Nous avons compare l'activite de 3 anticorps monoclonaux anti-digoxine, d'affinites differentes, a l'aide de modeles in vitro et in vivo. In vitro, la dissociation de la digoxine de son recepteur en presence d'anticorps est d'autant plus elevee que l'affinite de l'anticorps est grande. De plus, pour un anticorps donne, la dissociation est fonction d

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Pignotti, René-Pierre. "Digoxine et fonction ventriculaire gauche de la personne agee." Bordeaux 2, 1988. http://www.theses.fr/1988BOR25288.

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Oweis, Shadi. "Cardiotonic Steroids Down-Regulate Sodium Hydrogen Exchanger Expression in the Proximal Tubule Cells." University of Toledo Health Science Campus / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=mco1278521957.

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CLADET, PHILIPPE. "Digoxine - digitaline : le choix du traitement face au risque de surdosage chez la personne agee : a propos de 46 observations." Lille 2, 1990. http://www.theses.fr/1990LIL2M029.

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DAMASE, LUC. "Recherches pharmacologiques sur le mecanisme d'interaction digoxine amiodarone chez l'homme." Toulouse 3, 1988. http://www.theses.fr/1988TOU31164.

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Wahyono, Djoko. "Production et caractérisation d'anticorps monoclonaux dirigés contre la digoxine. Intérêt en immunoanalyse." Montpellier 1, 1990. http://www.theses.fr/1990MON13507.

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LAURANT, ERIC. "Intoxication grave au laurier rose : a propos d'un cas traite par les anticorps anti-digoxine." Clermont-Ferrand 1, 1991. http://www.theses.fr/1991CLF13061.

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Guedeney, Xavier. "Contribution à l'étude des composés digitaliques endogènes : propriétés immunologiques et biochimiques en période périnatale." Paris 5, 1988. http://www.theses.fr/1988PA05P614.

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BESSON, LAVEDAN SYLVIE. "Etude de la prescription de digoxine et de ses dosages seriques dans trente services du c. H. U. Purpan (toulouse) pendant deux ans." Toulouse 3, 1991. http://www.theses.fr/1991TOU31050.

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Marcaggi, P. "Intoxications digitaliques aigues : conduite a tenir en urgence ; interet de l'antidote anti-digoxine." Aix-Marseille 2, 1994. http://www.theses.fr/1994AIX20052.

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Commeau, Philippe. "Etude des variations de la pharmacocinétique et des effets pharmacodynamiques cardiovasculaires de la Digoxine sous l'influence de la coadministration de la Nicardipine chez l'homme en insuffisance cardiaque." Rouen, 1986. http://www.theses.fr/1986ROUE05NR.

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L'effet des inhibiteurs du canal calcique lent sur les taux sériques de digoxine a largement été étudié. Ces travaux ont principalement porté sur le vérapamil et la nifépipine Ces inhibiteurs calciques augmentent de façon significative les concentration,. Sériques de la digoxine , principalement par une réduction de la clearance totale de la digoxine. Par contre l'association nicardipine-digoxine a été beaucoup plus rarement étudiée. Le but de cette étude a été double i -apprécier l'influence de la nicardipine orale sur la pharmacocinétique de la digoxine -apprécier les variations éventuelles

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45

POULAIN, GELARD YVETTE. "Traitement des intoxications digitaliques massives par les anticorps anti-digoxine fractionnes (fab) : a propos d'un cas, revue de la litterature." Nantes, 1989. http://www.theses.fr/1989NANT005M.

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Navarro-Teulon, Isabelle. "Ingénierie génétique des immunoglobulines appliquée au diagnostic et à l'immunoanalyse : mise au point d'un nouvel immunodosage de Digoxine, construction de banques combinatoires de fragments d'anticorps anti-thyroglobuline." Montpellier 1, 1995. http://www.theses.fr/1995MON13508.

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Salphati, Laurent. "P-glycoproteine et cytochrome p450 3a : interactions potentielles et roles complementaires dans l'absorption et la disposition des drogues." Paris 11, 1998. http://www.theses.fr/1998PA114805.

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Mundet, i. Tudurí Xavier. "Estudi de la utilització de la digoxina. Utilitat de la digoxinèmia com a marcador del seu ús." Doctoral thesis, Universitat Autònoma de Barcelona, 1990. http://hdl.handle.net/10803/5401.

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Lacarelle, Bruno. "Contribution de la pharmacocinetique a la maitrise et a l'elucidation des origines de la variabilite de la reponse therapeutique : applications aux aminosides et a la digoxine." Aix-Marseille 2, 1988. http://www.theses.fr/1988AIX22963.

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Reibel, Monique. "Le dosage des digitaliques chez l'hemodialyse : pharmacocinetique de la digitoxine, presence d'une activite digitalis-like endogene." Strasbourg 1, 1988. http://www.theses.fr/1988STR1M058.

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