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Rozprawy doktorskie na temat „Disintegrant”

Autor: Grafiati

Data publikacji: 2 czerwca 2025

Data aktualizacji: 31 lipca 2025

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1

Mendonça, Rafaela Silva. "O papel da insularina, uma disintegrina recombinante (GST-INS), em processos de progressão tumoral: estudos in vitro." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/42/42133/tde-12092016-104116/.

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Plaquetas e células tumorais interagem em uma reação cruzada com proteínas do plasma, via integrina αIIbβ3 e αvβ3, respectivamente. A integrina αvβ3 também encontra-se presente na angiogênese tumoral. O objetivo desse trabalho foi avaliar a GST-INS, uma disintegrina recombinante do veneno de Bothrops insularis em eventos da progressão tumoral. Em condições estáticas, GST-INS foi capaz de inibir totalmente a adesão de células HUVECs e SK-MEL-28 às plaquetas em comparação ao controle e ao Aggrastat® (inibidor seletivo da integrina αIIbβ3). Além de inibir a

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Geppert, Harald-Gerhard. "Klonierung, Expression und Charakterisierung der Metalloproteinase-Domäne und Disintegrin-Domäne von humanem ADAM 15." [S.l. : s.n.], 2001. http://deposit.ddb.de/cgi-bin/dokserv?idn=96304849X.

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Pretorius, Milandi. "The evaluation and comparison of various tablet disintegrants / Milandi Pretorius." Thesis, North-West University, 2008. http://hdl.handle.net/10394/2315.

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Atherton, Ruth Elizabeth. "Catalytic activity and maturation of the metalloprotease-disintegrin protein, MDC9 /." Access full-text from WCMC, 1999. http://proquest.umi.com/pqdweb?did=733095101&sid=8&Fmt=2&clientId=8424&RQT=309&VName=PQD.

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Mattatall, Fiona M. "Disintegrin purification and characterization by biological activity and specificity." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/mq24683.pdf.

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6

Hundhausen, Christian. "Untersuchungen zur limitierten Proteolyse transmembraner Chemokine durch Disintegrin-ähnliche Metalloproteinasen." [S.l.] : [s.n.], 2005. http://e-diss.uni-kiel.de/diss_1497/d1497.pdf.

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Bull, Camilla Louise. "Localisation and expression of epididymal apical protein I." Thesis, University of Bristol, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.319142.

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8

Schneider, Ryan Anthony. "Regulation of tumor growth by synthetic disintegrins or depletion of PIN1." The Ohio State University, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=osu1291159683.

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9

Kang, Tiebang. "Intracellular activation and processing of human disintegrin and metalloproteinase 19 (hADAM19)." [S.l.] : [s.n.], 2003. http://deposit.ddb.de/cgi-bin/dokserv?idn=968455743.

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10

Maretzky, Thorsten. "Funktionelle Analyse der proteolytischen Spaltung von Adhäsionsmolekülen durch Disintegrin-ähnliche Metalloproteasen." [S.l.] : [s.n.], 2005. http://e-diss.uni-kiel.de/diss_1613/d1613.pdf.

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11

Tian, Jing. "Inhibition of melanoma cell motility by the snake venom disintegrin eristostatin." Access to citation, abstract and download form provided by ProQuest Information and Learning Company; downloadable PDF file, 61 p, 2007. http://proquest.umi.com/pqdweb?did=1397900451&sid=10&Fmt=2&clientId=8331&RQT=309&VName=PQD.

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12

Wayne, Gareth. "'The use of Fluorescent Substrates in the Characterisation of Disintegrin Metallopeptidases'." Thesis, University of East Anglia, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.490592.

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The development of higher wavelength Forster (Fluorescence) Resonance Energy Transfer (FRED substrates has provided a useful enabling tool for the purposes of studying the interactions of drugs, and potential drugs, with biologically active proteins in vitro, overcoming many of the problems such as poor sensitivity and interference associated with traditional fluorescent substrates. In particular these substrates have proven highly useful to the study of peptidases (the proteins responsible for hydrolytic cleavage of the peptide bonds between amino acids during peptide/protein catabolism) wher

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13

Cakebread, Julie Ann. "Genetic and molecular characterisation of A Disintegrin and Metalloprotease (ADAM) 33." Thesis, University of Southampton, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.436931.

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Menon, Vasudev Ramdas. "Analysis of the role and regulation of disintegrin metalloproteases in renal fibrosis." Thesis, University of Glasgow, 2012. http://theses.gla.ac.uk/3872/.

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Chronic Kidney Disease (CKD) affects about 10-20% of the adult population of the developed world. The underlying molecular mechanisms contributing to its varied pathophysiology CKD are still unclear. Without early diagnosis and therapeutic intervention, patients with CKD risk progressing to end stage renal failure (ESRF) requiring renal replacement therapy such as dialysis and eventually a renal transplant. Tubulointerstitial fibrosis is the common end point in most progressive renal diseases and has consistently been shown to be the best histological predictor of progression towards end stage

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15

Walsh, Erin. "Crossreactivity of alpha9beta1 integrin with p75NTR in modulation of proinvasive activities of glioma cells." Diss., Temple University Libraries, 2011. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/143048.

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Biology<br>Ph.D.<br>Gliomas are the most common and difficult to treat tumors of the central nervous system. Current treatments often fail to slow progression of disease due to the high invasive nature of glioma leading to a high percentage of recurrence. Our previous studies have demonstrated that the levels of alpha; 9 beta; 1 integrin found on high grade glioma were significantly increased in comparison to normal brain tissue where the levels were negligible. We also found that interaction between alpha; 9 beta; 1 integrin and nerve growth factor (NGF) plays a major role in progression of e

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16

Evers, Astrid [Verfasser]. "Transaktivierung des EGF-Rezeptors in Abhängigkeit von Disintegrin-ähnlichen Metalloproteasen (ADAMs) / Astrid Evers." Kiel : Universitätsbibliothek Kiel, 2013. http://d-nb.info/1036242722/34.

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17

Müller, Miryam [Verfasser]. "The role of a disintegrin and metalloprotease 10 in the liver / Miryam Müller." Kiel : Universitätsbibliothek Kiel, 2018. http://d-nb.info/1169132553/34.

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18

Norris, Jeffrey William. "Biophysical properties of disintegrin loop peptides that initiate the development of Xenopus laevis /." For electronic version search Digital dissertations database. Restricted to UC campuses. Access is free to UC campus dissertations, 2002. http://uclibs.org/PID/11984.

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Bella, Angelo. "Synthetic disintegrins as mediators of cell-matrix interactions : implication for cancer and regenerative therapies." Thesis, University of Leicester, 2011. http://hdl.handle.net/2381/9996.

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The term disintegrin was coined in the early 90s to describe a class of proteins found in snake venoms. The same term is used today for molecules that can recognise and bind to integrins: membrane receptors that are responsible for the activation of many vital pathways that lead to cell proliferation. By binding integrins, disintegrins can stop the internal cellular signalling, which can result in apoptosis, induced cell death. Laminin is a trimeric glycoprotein, found in the extracellular matrix, formed from three different chains: α, β and γ and is also involved in the binding of integrins.

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20

Hamel, Michelle Grace. "Modulation of neural plasticity by the ADAMTSs (a disintegrin and metalloproteinase with thrombospondin motifs)." [Tampa, Fla] : University of South Florida, 2006. http://purl.fcla.edu/usf/dc/et/SFE0001684.

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21

Kordowski, Felix [Verfasser]. "Epigenetic and posttranslational regulation of the disintegrin and metalloproteases ADAM17 and ADAMTS-16 / Felix Kordowski." Kiel : Universitätsbibliothek Kiel, 2019. http://d-nb.info/1181096847/34.

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22

Kelwick, Richard John Robert. "The role of A Disintegrin and Metalloproteinase with thrombospondin motifs-15 (ADAMTS-15) in breast cancer." Thesis, University of East Anglia, 2013. https://ueaeprints.uea.ac.uk/48756/.

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Breast cancer is the most common cancer in women and in 2008 accounted for 8% of UK cancer related deaths. A poor prognosis is particularly conferred upon individuals with evidence of metastatic breast cancer. With some studies noting that at least 70% of patients dying with breast cancer have evidence of metastatic disease. In order to develop novel therapeutic strategies a greater understanding of breast cancer tumourigenesis and metastasis is required. Metalloproteinases were implicated as key drivers of metastasis through their ability to degrade the components of the extracellular matrix.

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23

Gaultier, Alban. "Analyse fonctionnelle de la région adhésive de la protéine ADAM13." Paris 6, 2002. http://www.theses.fr/2002PA066153.

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Stevanovic, Marija [Verfasser]. "Analysis of A Disintegrin and Metalloprotease 17 (ADAM17) in the metastatic niche of the lung / Marija Stevanovic." Kiel : Universitätsbibliothek Kiel, 2017. http://d-nb.info/1137509686/34.

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Pang, Yun Yun. "Investigating the proteolytic function of A disintegrin and metalloproteinase 33 (ADAM33) and its role in asthma pathogenesis." Thesis, University of Southampton, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.443074.

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26

Mino, Nobuya. "A Disintegrin and Metalloprotease 12 (ADAM12) is a Prognostic Factor in Resected Pathological Stage I Lung Adenocarcinoma." Kyoto University, 2010. http://hdl.handle.net/2433/97946.

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Jolly, Carrie E. "Localization of a Microsporidia ADAM (A Disintegrin and Metalloprotease Domain) Protein and Identification of Potential Binding Partners." Digital Commons @ East Tennessee State University, 2007. https://dc.etsu.edu/etd/2052.

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Microsporidia are spore-forming, obligate intracellular pathogens typically associated with opportunistic infections in immunocompromised individuals. Treatment options for microsporidia infections in humans are limited and additional research is necessary to create better therapeutic agents. For many pathogenic organisms, adhesion to the host cell surface is a prerequisite for tissue colonization and invasion. Our previous research has demonstrated a direct relationship between adherence of microsporidia spores to the surface of host cells and infectivity in vitro. In an effort to better unde

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28

Lusa, Ana Letícia Gori. "Estudos bioquímicos e biofísicos de metaloproteinases/desintegrinas de venenos de serpentes." Universidade de São Paulo, 2008. http://www.teses.usp.br/teses/disponiveis/76/76132/tde-13052010-144612/.

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Metaloproteases/desintegrinas (MD) isoladas de venenos de serpentes são potentes inibidores de agregação plaquetária e de adesão celular, processos envolvidos em doenças como trombose e câncer. As MD pertencem a classe PIII das SVMPs (´snake venom metalloproteinases´) que são constituídas por três domínios: metaloprotease (M), tipo-desintegrina (D) e rico em cisteína (C). A função dos três domínios nas atividades das moléculas ainda não é totalmente conhecida, e estudos com o objetivo de esclarecer suas funções são importantes para o desenvolvimento de novos fármacos. Algumas proteínas da clas

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29

Gibb, David. "ADAM10 is a critical regulator of B cell development, antibody production, and myeloid-derived suppressor cell expansion: Effects of B cell-specific ADAM10 deletion and overexpression in vivo." VCU Scholars Compass, 2010. http://scholarscompass.vcu.edu/etd/2269.

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Proteolytic processing of transmembrane receptors and ligands can have dramatic effects on cell signaling and subsequent cellular responses. Previous studies demonstrated that a disintegrin and metalloproteinase 10 (ADAM10) may cleave numerous B cell-expressed receptors, including the low affinity IgE receptor (CD23). However, lethality of ADAM10-deficient embryos has limited examination of these cleavage events in lymphocytes. To investigate their role in B cell development and function, we generated B cell-specific ADAM10 knockout mice. Intriguingly, deletion prevented development of the ent

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30

Groth, Esther Verfasser], Andreas [Akademischer Betreuer] Ludwig, Marlies [Akademischer Betreuer] Fabry, and Gabriele [Akademischer Betreuer] [Pradel. "Regulation und Transport der Disintegrin und Metalloproteinasen ADAM10 und ADAM17 / Esther Groth ; Andreas Ludwig, Marlies Fabry, Gabriele Pradel." Aachen : Universitätsbibliothek der RWTH Aachen, 2016. http://d-nb.info/1138988707/34.

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Dentten, Ellen Dilys. "Expression and characterisation of the catalytic and disintegrin domains of MS2, a major surface antigen on mouse macrophages." Thesis, University of Kent, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.246579.

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Groth, Esther [Verfasser], Andreas [Akademischer Betreuer] Ludwig, Marlies [Akademischer Betreuer] Fabry, and Gabriele [Akademischer Betreuer] Pradel. "Regulation und Transport der Disintegrin und Metalloproteinasen ADAM10 und ADAM17 / Esther Groth ; Andreas Ludwig, Marlies Fabry, Gabriele Pradel." Aachen : Universitätsbibliothek der RWTH Aachen, 2016. http://nbn-resolving.de/urn:nbn:de:hbz:82-rwth-2016-012105.

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Groth, Esther [Verfasser], Andreas Akademischer Betreuer] Ludwig, Marlies [Akademischer Betreuer] [Fabry, and Gabriele [Akademischer Betreuer] Pradel. "Regulation und Transport der Disintegrin und Metalloproteinasen ADAM10 und ADAM17 / Esther Groth ; Andreas Ludwig, Marlies Fabry, Gabriele Pradel." Aachen : Universitätsbibliothek der RWTH Aachen, 2016. http://d-nb.info/1138988707/34.

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Clissa, Patricia Bianca. "Caracterização do Efeito da Jacaragina sobre a Produção e Liberação de Citocinas Pró-inflamatórias em Modelo Murino." Universidade de São Paulo, 2002. http://www.teses.usp.br/teses/disponiveis/42/42133/tde-20062002-113130/.

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O efeito inflamatório da jararagina, toxina hemorrágica do veneno de Bothrops jararaca, foi avaliado através de um sistema in vitro (células peritoneais murinas-MPACs) e in vivo (coxim plantar de camundongos), onde foi avaliada a produção de mRNA que codifica as citocinas TNF-a, IL-1b e IL-6 por RT-PCR e a liberação destas no sobrenadante de cultura e no local de injeção (ELISA). Além disso, o domínio da jararagina responsável pela liberação local das citocinas foi estudado. Nossos resultados mostram que a jararagina induziu a expressão de mRNA que codifica para o TNF-a, IL-1b e IL-6 em MPACs,

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Sahin, A. R. Umut. "The role of metalloprotease-disintegrin (ADAM) proteins in postranslational processing of EGF receptor ligands and insights into regulatory mechanisms /." View online version; access limited to Brown University users, 2005. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pqdiss&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&rft_dat=xri:pqdiss:3174669.

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Gonçalves, Daniele Fernanda Chiarelli. "Minimização da estrutura da DisBa-01, uma desintegrina com potenciais atividades anti-trombótica e anti-metastática." Universidade de São Paulo, 2008. http://www.teses.usp.br/teses/disponiveis/76/76132/tde-12052008-185026/.

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A DisBa-01, uma desintegrina RGD recombinante ainda não isolada do veneno de Bothrops alternatus, exibe alta afinidade pela integrina aIIbB3, contribuindo para inibição da agregação plaquetária (RAMOS, 2005). DisBa-01 possui também atividades anti-trombótica e anti-metastática comprovadas in vivo (Ramos, 2005). A fim de obter moléculas menores mantendo as atividades da DisBa-01, dois mutantes estão em estudo. Moléculas chamadas DisBa (1-32) e DisBa (1-36) apresentam 32 e 36 resíduos a menos que a DisBa-01, respectivamente, na região N-terminal. Oligonucleotídeos foram construídos e os DNAs for

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Bozkulak, Esra Cagavi. "Characterization of roles for the disintegrin and metalloproteases, Kuzbanian and tumor necrosis factor-alpha converting enzyme, in mammalian notch signaling." Diss., Restricted to subscribing institutions, 2009. http://proquest.umi.com/pqdweb?did=1835418681&sid=10&Fmt=2&clientId=1564&RQT=309&VName=PQD.

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Coronado, Mônika Aparecida. "Estudo por Modelagem e Dinâmica Molecular da Interação da Integrina alfa6beta1 com o Domínio Tipo-disintegrina de ADAM2 E ADAM9 Humanas." Laboratório Nacional de Computação Científica, 2008. http://www.lncc.br/tdmc/tde_busca/arquivo.php?codArquivo=148.

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A integração entre o citoesqueleto celular e a MEC mediada pelas integrinas gera a produção de força mecânica sobre a membrana plasmática. Isto permite às células gerar tração durante sua migração e tensão durante o remodelamento da MEC. Várias proteínas com diferentes funções já foram identificadas como ligantes das subunidades a e b das integrinas. O estudo de proteínas capazes de se ligar e interferir na sinalização via integrina, como as desintegrinas-like e cisteina-rich presentes nos venenos de serpente e proteínas conhecidas como ADAM (A Disintegrin And Metaloprotease), torna-se cada ve

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Aghababaei, Mahroo. "A disintegrin and metalloproteinase 12 (ADAM12) localizes to invasive trophoblast, promotes cell invasion and directs column outgrowth in early placental development." Thesis, University of British Columbia, 2015. http://hdl.handle.net/2429/54045.

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Placental development is a highly regulated process requiring signals from both fetal and maternal uterine compartments. Within this complex system, trophoblasts, placental cells of epithelial lineage, form the maternal-fetal interface controlling nutrient, gas and waste exchange. The commitment of progenitor villous cytotrophoblasts to differentiate into diverse trophoblast subsets is a fundamental process in placental development. Differentiation of trophoblasts into invasive stromal- and vascular- remodeling subtypes is essential for uterine arterial remodeling and placental function. Inade

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Wetzel, Sebastian [Verfasser]. "Analyse der Funktionen der A Disintegrin und Metalloprotease 10 (ADAM10) in Leber und Niere und der Regulation der Proteaseaktivität / Sebastian Wetzel." Kiel : Universitätsbibliothek Kiel, 2019. http://d-nb.info/1192755421/34.

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Ashlin, Timothy. "Studies on a disintegrin and metalloproteinase with thrombospondin motifs-1, -4 and -5 and the regulation of their gene expression in macrophages." Thesis, Cardiff University, 2012. http://orca.cf.ac.uk/42104/.

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A disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) are a family of proteins that are closely related to the matrix metalloproteinases (MMPs). It has been suggested that the proteins have a critical role in the breakdown of articular cartilage during osteoarthritis (OA). More recently it has been suggested that their actions could potentially regulate atherosclerotic plaque stability. Atherosclerosis is a chronic, inflammatory disorder characterised by lipid and cholesterol accumulation and the development of fibrotic plaques within the walls of large and medium arteries. T

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Seipold, Lisa [Verfasser], Paul [Akademischer Betreuer] Saftig, and Eric [Gutachter] Beitz. "The role of tetraspanins in the regulation of the A Disintegrin and Metalloprotease 10 (ADAM10) / Lisa Seipold ; Gutachter: Eric Beitz ; Betreuer: Paul Saftig." Kiel : Universitätsbibliothek Kiel, 2017. http://d-nb.info/1236287533/34.

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Martin, Ana Carolina Baptista Moreno. "Papel do domínio desintegrina da ADAM9 humana na modulação da migração e invasão de células tumorais." Universidade Federal de São Carlos, 2011. https://repositorio.ufscar.br/handle/ufscar/5484.

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Made available in DSpace on 2016-06-02T20:21:26Z (GMT). No. of bitstreams: 1 3510.pdf: 4191245 bytes, checksum: 06d51dcbc27b48e71902ca9fa212b568 (MD5) Previous issue date: 2011-02-25<br>Universidade Federal de Sao Carlos<br>Cancer metastasis is the major cause of death, consequently studies to understand the molecular mechanisms involved in this process are essential to the knowledge of this disease. Cell migration and invasion are part of the metastatic process; therefore, molecules that are able to prevent cell migration can be used as model to develop new anti-metastasis drugs. The aim

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Vieira, Puebla Cassini. "Ensaio pré-clínico da desintegrina recombinante DisBa-01 na angio-gênese inflamatória induzida por implantes sintéticos em camundongos." Universidade Federal de Uberlândia, 2014. https://repositorio.ufu.br/handle/123456789/12421.

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Angiogenesis and inflammation act simultaneously in several pathophysiological processes. The interactions with the extracellular matrix (ECM) are required in inflammatory angiogenesis. The non-enzymatic disintegrins comprise a family of peptides, low molecular weight, derived from the venom of snakes, which strongly inhibit the functions of integrins. In this study we evaluated the therapeutic effect of disintegrin DisBa-01, derived from the venom of the snake Rhinocerophis alternatus in inflammatory angiogenesis induced by synthetic implants in mice. Treatment with DisBa-01 inhibited the mai

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Haitchi, Hans Michael. "The expression and function of the asthma susceptibility gene, a Disintegrin and Metalloprotease (ADAM) 33, in airways of normal and asthmatic subjects and in developing lungs." Thesis, University of Southampton, 2008. https://eprints.soton.ac.uk/380396/.

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Asthma affects 1 in 12 adults and 1 in 10 children in the UK. It is a complex disease involving genetic and environmental factors. ADAM33 is an asthma susceptibility gene whose polymorphic variation has been linked to asthma and bronchial hyperresponsiveness, as well as decline in lung function in asthma and COPD and reduced lung function in young children. ADAM33 mRNA is almost exclusively expressed in mesenchymal cells, such as fibroblasts, myofibroblasts and smooth muscle cells. These cells play an important role in modelling of the airways during lung development and in remodelling of the

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Soulairol, Ian. "Etude des phénomènes liés à la conception de mini-comprimés orodispersibles par compression directe." Thesis, Montpellier, 2017. http://www.theses.fr/2017MONTT115/document.

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La possibilité d’administrer des formes sèches orales est encore de nos jours un enjeu dans certaines spécialités médicales telles que la pédiatrie, la neurologie ou la gériatrie. Les mini-comprimés orodispersibles présentent un intérêt majeur pour répondre à cette problématique.L’objectif de ce travail est d’étudier les différents phénomènes qui régissent la conception de cette forme pharmaceutique par compression directe.Trois axes de recherche ont été fixés pour la réalisation de ce travail : - Premièrement, étudier les paramètres de formulation et de fabrication des mini-comprimés orodispe

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Pontes, Carmen Lucia Salla. "Otimização da purificação e caracterização adicional de uma desintegrina-RGD recombinante de Bothrops alternatus e seu efeito em células endoteliais humanas (HUVEC)." Universidade Federal de São Carlos, 2006. https://repositorio.ufscar.br/handle/ufscar/5435.

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Made available in DSpace on 2016-06-02T20:21:18Z (GMT). No. of bitstreams: 1 DissCLSP.pdf: 1835751 bytes, checksum: 94d92e1d4b14f4f8befcd6cb0b350de1 (MD5) Previous issue date: 2006-11-23<br>Universidade Federal de Sao Carlos<br>Disintegrins are snake venom protein, of low molecular weight, rich in cysteines and RGDcontaining peptides that bind specifically to integrins αIIbβ3, α5β1, and αvβ3 expressed on platelets, endothelial and tumor cells. The biological effects of these peptides are related with biological process of cellular adhesion where receptors ca

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Muniz, João Renato Carvalho. "Estrutura tridimensional da bothropasina, uma metaloprotease/desintegrina do veneno de bothrops jararaca." Universidade de São Paulo, 2007. http://www.teses.usp.br/teses/disponiveis/76/76132/tde-05062008-160009/.

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A bothropasina é uma proteína hemorrágica de 48 kDa, pertencente à classe P-III das metaloproteases, isolada a partir do veneno bruto da serpente brasileira Bothrops jararaca, e que possui os domínios adesivos desintegrina (D) e rico em cisteína (C). Neste trabalho, nós apresentamos a estrutura cristalográfica da bothropasina complexada ao inibidor POL647. O domínio catalítico , metaloprotease (M), pode ser dividido em dois subdomínios, dispostos de maneira muito similar aos descritos para essa família de metaloproteases de venenos de serpentes (em inglês \"SVMPs\"), que inclui os sítios de li

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Georges, Steven. "Implication d’Adam12 dans la pathogenèse des ostéosarcomes." Nantes, 2012. http://archive.bu.univ-nantes.fr/pollux/show.action?id=310ddbf4-e5ad-42a3-9c69-32cd8dd77fe1.

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L'ostéosarcome est une tumeur osseuse primitive maligne qui survient généralement sur une population jeune. La problématique biologique de ce cancer repose en partie sur l'existence d'un cercle vicieux qui s'établit entre la phase de croissance tumorale et la phase de résorption osseuse. Une nouvelle stratégie thérapeutique consiste ainsi à cibler à la fois les cellules tumorales mais également l'ostéolyse associée. Il est donc nécessaire de définir de nouvelles cibles protéiques favorisant ce processus pro-tumoral. La première partie de ce travail de thèse a permis d'identifier une métallopro

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Wise, Randi. "The role of the secretory pathway and cell surface proteolysis in the regulation of the aggressiveness of breast cancer cells." Diss., Kansas State University, 2017. http://hdl.handle.net/2097/38199.

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Doctor of Philosophy<br>Biochemistry and Molecular Biophysics Interdepartmental Program<br>Anna Zolkiewska<br>Cancer cells exploit key signaling pathways in order to survive, proliferate, and metastasize. Understanding the intricacies of the aberrant signaling in cancer may provide new insight into how to therapeutically target tumor cells. The goal of my research was to explore the role of two modulators of transmembrane signaling, the secretory pathway and cell surface proteolysis, in the aggressiveness of breast cancer cells. To study the role of the secretory pathway, I focused on the fami

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