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Rozprawy doktorskie na temat „DNA – Analysis”

Autor: Grafiati

Data publikacji: 4 czerwca 2021

Data aktualizacji: 25 lipca 2025

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1

Rifaat, Rasekh. "Multifractal analysis of DNA." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape17/PQDD_0007/MQ32231.pdf.

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Stephens, Nathan W. "A comparison of genetic microarray analyses : a mixed models approach versus the significance analysis of microarrays /." Diss., CLICK HERE for online access, 2006. http://contentdm.lib.byu.edu/ETD/image/etd1604.pdf.

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3

McClelland, Robyn L. (Robyn Leagh). "Statistical analysis of DNA profiles." Thesis, McGill University, 1994. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=68215.

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DNA profiles have become an extremely important tool in forensic investigations, and a match between a suspect and a crime scene specimen is highly incriminating. Presentation of this evidence in court, however, requires a statistical interpretation, one which reflects the uncertainty in the results due to measurement imprecision and sampling variability. No consensus has been reached about how to quantify this uncertainty, and the literature to date is lacking an objective review of possible methods.<br>This thesis provides a survey of approaches to statistical analysis of DNA profile data cu

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4

O'Donoghue, Kerry. "Chemical analysis of ancient DNA." Thesis, University of Manchester, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.488296.

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5

Akman, Kemal. "Bioinformatics of DNA Methylation analysis." Diss., Ludwig-Maximilians-Universität München, 2014. http://nbn-resolving.de/urn:nbn:de:bvb:19-182873.

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6

Hastings, Patsy-Ann Susan. "MITOCHONDRIAL DNA ANALYSIS BY PYROSEQUENCING." Master's thesis, University of Central Florida, 2004. http://digital.library.ucf.edu/cdm/ref/collection/ETD/id/4447.

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Mitochondrial DNA (deoxyribo nucleic acid) is typically used in forensic casework when small quantities of high molecular weight quality DNA is not expected to be present thus negating the chances of obtaining usable nuclear DNA. Typical samples that utilized mitochondrial DNA analysis are: hair, bones, teeth, ancient remains (samples or remains that are at least 100 years old) or very old samples (samples that are less than 100 but greater than 10 years old). The current method used to evaluate mitochondrial DNA is Sanger sequencing. Although robust, it is also time consuming and labor intens

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7

Wang, Meng. "Mutational analysis of DNA deaminases." Thesis, University of Cambridge, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.611829.

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8

Salman, Abbas Ali Abulwohab. "Miniaturised system for DNA analysis." Thesis, Teesside University, 2013. http://hdl.handle.net/10149/316214.

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The growing markets for analytical techniques in areas such as pathogen detection, clinical analysis, forensic investigation, environmental analysis and food analysis require the development of devices with simultaneous high performance, speed, simplicity and low cost. Analysis of deoxyribonucleic acid (DNA) has been enhanced by use of the polymerase chain reaction (PCR) technique, which is now a widely used tool for in vitro amplification of nucleic acids. In this work, a miniaturised PCR system comprising a microfluidic PCR chip, novel heating method and fluorescence detection unit was devel

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9

Poli, Elena. "DNA METHYLATION ANALYSIS IN RHABDOMYOSARCOMA." Doctoral thesis, Università degli studi di Padova, 2016. http://hdl.handle.net/11577/3424380.

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Rhabdomyosarcoma (RMS) is a highly aggressive pediatric soft-tissue sarcoma. It is mainly classified into two major subtypes characterized by alveolar (ARMS) and embryonal (ERMS) histologies. ARMS are characterized by a more aggressive behavior with a higher tendency to present metastasis at diagnosis and to relapse after treatment. Approximately 80% of ARMS harbour the reciprocal chromosomal translocation t(2;13)(q35;q14) and, less commonly, the variant translocation t(1;13)(p36;q14), in which PAX3 and FOXO1, or PAX7 and FOXO1 genes, respectively, are juxtaposed. Unfortunately, no such specif

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10

Zhang, Jianhua. "Restriction fragment length polymorphism analysis of chloroplast DNA, mitochondrial DNA, and ribosomal DNA in turfgrasses." Diss., This resource online, 1994. http://scholar.lib.vt.edu/theses/available/etd-06062008-170748/.

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11

Patel, Yogen. "DNA methylation analysis of Alzheimer's disease." Thesis, King's College London (University of London), 2013. https://kclpure.kcl.ac.uk/portal/en/theses/dna-methylation-analysis-of-alzheimers-disease(f66ad885-3fdd-4c12-a73a-921cc31ccac2).html.

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There is evidence for a role for epigenetic mechanisms in Alzheimer's disease (AD), the most common age-dependent neurodegenerative disorder. The most studied epigenetic mark DNA methylation -the addition of a methyl group to cytosines located in CpG dinucleotides (5mC) - is known to change with aging and may reflect subtle changes in gene expression. Recently a second type of modified cytosine - a hydroxylated and methylated form (5hmC) - has been detected in the brain and maybe linked to the regulation of gene expression. Case-control differences in post-mortem brain DNA methylation were sou

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12

Gomaa, R. "Analysis of mitochondrial DNA variation in the Egyptian population and its implications for forensic DNA analysis." Thesis, Nottingham Trent University, 2010. http://irep.ntu.ac.uk/id/eprint/357/.

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The genetic sequence of human mitochondrial DNA (mtDNA) is of particular interest to forensic investigations involving human identification, as well as population genetics. The current mtDNA database is lacking sufficient representatives of African mitochondrial DNA sequences compared to European and Asian sequences. The present study was concerned with the analysis of mtDNA in the Egyptian population. FTA cards were used for blood sample collection, storage, and shipment and DNA extraction. An optimised laboratory protocol for rapid PCR amplification of the mitochondrial hypervariable regions

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13

Hare, Brian K. Dinakarpandian Deendayal. "Feature selection in DNA microarray analysis." Diss., UMK access, 2004.

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Thesis (M.S.)--School of Computing and Engineering. University of Missouri--Kansas City, 2004.<br>"A thesis in computer science." Typescript. Advisor: D. Dinakarpandian. Vita. Title from "catalog record" of the print edition Description based on contents viewed Feb. 24, 2006. Includes bibliographical references (leaves 81-86 ). Online version of the print edition.

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14

Nilsson, Martina. "Mitochondrial DNA in Sensitive Forensic Analysis." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-7458.

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15

Dahl, Fredrik. "Selector Technology : For Multiplex DNA Analysis." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-5921.

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16

Shah, Jayna J. "Microfluidic devices for forensic DNA analysis." Fairfax, VA : George Mason University, 2007. http://hdl.handle.net/1920/2878.

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Thesis (Ph. D.)--George Mason University, 2007.<br>Title from PDF t.p. (viewed Jan. 22, 2008). Thesis director: Rao V. Mulpuri. Submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy in Electrical and Computer Engineering. Vita: p. 159. Includes bibliographical references (p. 145-158). Also available in print.

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17

Brandt, Regine, Robert Grützmann, Andrea Bauer, et al. "DNA microarray analysis of pancreatic malignancies." Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2014. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-136556.

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Pancreatic ductal adenocarcinoma (PDAC) has an extremely poor prognosis. To improve the prognosis, novel molecular markers and targets for earlier diagnosis and adjuvant and/or neoadjuvant treatment are needed. Recent advances in human genome research and high-throughput molecular technologies make it possible to cope with the molecular complexity of malignant tumors. With DNA array technology, mRNA expression levels of thousand of genes can be measured simultaneously in a single assay. As several studies using microarrays in PDAC have already been published, this review attempts to compare th

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18

Meade, Andrew Paul. "The computational analysis of DNA sequences." Thesis, University of Reading, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.412195.

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19

Murry, Robert Lester. "Continuum electrostatic analysis of DNA bending." Thesis, Massachusetts Institute of Technology, 1996. http://hdl.handle.net/1721.1/38837.

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20

Ahnesorg, Peter. "Molecular genetic analysis of DNA repair." Thesis, University of Cambridge, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.614127.

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21

Pechstedt, Katrin. "A nanotechnology approach to DNA analysis." Thesis, University of Southampton, 2011. https://eprints.soton.ac.uk/340250/.

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This thesis describes the investigation of quantum dots and nano-structured metallic films for use in single genomic DNA analysis. The fluorescence of continuously illuminated core/shell CdSe/ZnS quantum dots (QDs) under various atmospheric conditions is investigated experimentally. Initial enhancement in fluorescence intensity is observed followed by degradation; both are highly dependent on the atmospheric conditions. Following a series of studies theories are put forward to explain these observations. Solution mixtures of DNA strands and QDs are imaged with Atomic Force Microscopy and Fluor

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22

Brandt, Regine, Robert Grützmann, Andrea Bauer, et al. "DNA microarray analysis of pancreatic malignancies." Karger, 2004. https://tud.qucosa.de/id/qucosa%3A27711.

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Pancreatic ductal adenocarcinoma (PDAC) has an extremely poor prognosis. To improve the prognosis, novel molecular markers and targets for earlier diagnosis and adjuvant and/or neoadjuvant treatment are needed. Recent advances in human genome research and high-throughput molecular technologies make it possible to cope with the molecular complexity of malignant tumors. With DNA array technology, mRNA expression levels of thousand of genes can be measured simultaneously in a single assay. As several studies using microarrays in PDAC have already been published, this review attempts to compare th

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23

Jones, Nathan Jones. "Single Molecule Analysis of DNA Interactions." The Ohio State University, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=osu1511959163350735.

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24

Watt, Kathryn Elizabeth. "Decontamination techniques in ancient DNA analysis /." Burnaby B.C. : Simon Fraser University, 2005. http://ir.lib.sfu.ca/handle/1892/2446.

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25

Molak, Martyna. "Evolutionary Analysis of Ancient DNA Sequences." Thesis, The University of Sydney, 2014. http://hdl.handle.net/2123/11674.

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Studies of genetic data from old specimens – ancient DNA – offer a unique possibility to explore evolutionary history. Ancient DNA allows examination of past populations, extinct prehistoric species, and even large-scale analyses of past ecosystems. Since the beginnings of ancient DNA research in the mid 1980s, the field has undergone major technological and methodological transitions. However, investigations of the theory and methods used to analyse ancient DNA sequences have not kept up with the rapid pace of data generation. This thesis investigates a number of issues associated with the e

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26

Bowler, Frank Ray. "Reading DNA with PNA : a dynamic chemical approach to DNA sequence analysis." Thesis, University of Edinburgh, 2011. http://hdl.handle.net/1842/5270.

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Single nucleotide polymorphisms (SNPs) and insertions/deletions (indels) constitute important sources of genetic variation which provide insight into disease aetiology and idiosyncratic differences in drug response. The analysis of such genetic variation relies upon the generation of allele-specific products, typically by enzymatic extension or the hybridization of allele-specific DNA probes. Herein, a distinct enzyme-free, dynamic chemistry-based method of producing allele-specific products for genotyping was developed. The approach was initially demonstrated in model systems using synthetic

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27

Berge, Torunn. "Structural analysis of DNA and DNA-protein complexes using atomic force microscopy." Thesis, University of Cambridge, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.621339.

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28

Wang, Suyue. "Characterization of a Human 28S Ribosomal RNA Retropseudogene and Other Repetitive DNA Sequence Elements Isolated from a Human X Chromosome-Specific Library." Thesis, University of North Texas, 1994. https://digital.library.unt.edu/ark:/67531/metadc278083/.

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Three genomic clones encompassing human DNA segments (designated LhX-3, LhX-4, and LhX5) were isolated from an X chromosome-specific library and subjected to analysis by physical mapping and DNA sequencing. It was found that these three clones are very rich in repetitive DNA sequence elements and retropseudogenes.

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29

Easthon, Lindsey. "Conformational analysis of E. coli DnaT and the complex with PriA N-terminal domain." University of Toledo / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1271434912.

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30

Savill, Jane Marie. "Analysis of DNA damage sensing and DNA recombination using high-throughput functional genomics." Thesis, University of Cambridge, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.608872.

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31

Thomas, Adam David. "Mechanistic investigations of DNA reactive carcinogens at low dose, through analysis of DNA adducts, mutations and DNA repair." Thesis, Swansea University, 2012. https://cronfa.swan.ac.uk/Record/cronfa43089.

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Genetic toxicology assesses the genotoxic potential of chemicals in consumer products, pharmaceuticals and from agricultural and industrial processes. Such assessment is integral in hazard identification and risk assessment to prevent unnecessary human exposure and limit cancer risk. Human risk assessments for genotoxic alkylating agents were based upon linear dose-response models where genotoxicity accrues proportionally with dose. Evidence is accumulating to support a non-linear dose-response at low doses of ethyl methanesulfonate (EMS), a model alkylating agent. For acceptance of non-linear

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32

Ola, Ayodele Oluronke. "A functional analysis of proliferating cell nuclear antigen (PCNA)." Thesis, King's College London (University of London), 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.391441.

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33

Lee, Kyeong Eun. "Bayesian models for DNA microarray data analysis." Diss., Texas A&M University, 2005. http://hdl.handle.net/1969.1/2465.

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Selection of signi?cant genes via expression patterns is important in a microarray problem. Owing to small sample size and large number of variables (genes), the selection process can be unstable. This research proposes a hierarchical Bayesian model for gene (variable) selection. We employ latent variables in a regression setting and use a Bayesian mixture prior to perform the variable selection. Due to the binary nature of the data, the posterior distributions of the parameters are not in explicit form, and we need to use a combination of truncated sampling and Markov Chain Monte Carlo (MCMC)

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34

Seldeen, Kenneth Ladd. "Biophysical Analysis of the AP1-DNA Interaction." Scholarly Repository, 2009. http://scholarlyrepository.miami.edu/oa_dissertations/259.

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Jun and Fos are components of the AP1 family of transcription factors that bind to the promoters of a diverse multitude of genes involved in critical cellular responses such as cell growth and proliferation, cell cycle regulation, embryonic development and cancer. The specific protein-DNA interactions are driven by the binding of basic zipper (bZIP) domains of Jun and Fos to TPA response element (TRE) and cAMP response element (CRE) within the promoters of target genes. Here, using a diverse array of biophysical techniques, including in particular isothermal titration calorimetry in conjuncti

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35

Fellinger, Karin. "Analysis of Protein Interactions Controlling DNA Methyltransferases." Diss., lmu, 2009. http://nbn-resolving.de/urn:nbn:de:bvb:19-98919.

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36

Russom, Aman. "Microfluidic bead-based methods for DNA analysis." Doctoral thesis, KTH, Skolan för elektro- och systemteknik (EES), 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-155.

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With the completion of the human genome sequencing project, attention is currently shifting toward understanding how genetic variation, such as single nucleotide polymorphism (SNP), leads to disease. To identify, understand, and control biological mechanisms of living organisms, the enormous amounts of accumulated sequence information must be coupled to faster, cheaper, and more powerful technologies for DNA, RNA, and protein analysis. One approach is the miniaturization of analytical methods through the application of microfluidics, which involves the manipulation of fluids in micrometer-size

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37

Edlund, Hanna. "Sensitive Identification Tools in Forensic DNA Analysis." Doctoral thesis, Uppsala universitet, Institutionen för genetik och patologi, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-131904.

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DNA as forensic evidence is valuable in criminal investigations. Implementation of new, sensitive and fast technologies is an important part of forensic genetic research. This thesis aims to evaluate new sensitive methods to apply in forensic DNA analysis including analysis of old skeletal remains. In Paper I and II, two novel systems for analysis of STRs, based on the Pyrosequencing technology, are presented. In Paper I, Y chromosomal STRs are analysed. Markers on the male specific Y chromosome are especially useful in analysis of DNA mixtures. In Paper II, ten autosomal STRs are genotyped. T

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38

Freeman, Emmerson Clare. "Molecular analysis of mutant human mitochondrial DNA." Thesis, University of Oxford, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.297942.

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39

Hon, Wing-hong, and 韓永康. "Analysis of DNA shuffling by computer simulation." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2003. http://hub.hku.hk/bib/B27771027.

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40

高銘謙 and Ming-him Ko. "A multi-agent model for DNA analysis." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1999. http://hub.hku.hk/bib/B31222778.

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41

Shahran, M. K. "The analysis of flow cytometric DNA data." Thesis, University of Nottingham, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.371132.

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42

Routledge, Michael Norman. "'3'2p-Postlabelling analysis of carcinogen DNA adducts." Thesis, University of York, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.292540.

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43

Ghorbani, Mohammadmersad. "Computational analysis of CpG site DNA methylation." Thesis, Brunel University, 2013. http://bura.brunel.ac.uk/handle/2438/8217.

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Epigenetics is the study of factors that can change DNA and passed to next generation without change to DNA sequence. DNA methylation is one of the categories of epigenetic change. DNA methylation is the attachment of methyl group (CH3) to DNA. Most of the time it occurs in the sequences that G is followed by C known as CpG sites and by addition of methyl to the cytosine residue. As science and technology progress new data are available about individual’s DNA methylation profile in different conditions. Also new features discovered that can have role in DNA methylation. The availability of new

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44

Odell, Mark. "An analysis of vaccinia virus DNA ligase." Thesis, University of Oxford, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.670258.

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45

Van, Winkle Carolyn. "Forensic DNA Extraction Strategies for PCR Analysis." Thesis, University of North Texas, 1998. https://digital.library.unt.edu/ark:/67531/metadc278269/.

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There is a transition nationwide on the analysis of forensic evidentiary stains containing biological material from traditional serology to Polymerase Chain Reaction (PCR) methodologies. The increased sensitivity of PCR, the limited number of alleles at each locus, and the necessity of producing unambiguous data for entry into the FBI's Combined DNA Index System make this study of extraction procedures of utmost importance. A "single tube" extraction procedure for blood stains collected onto FTA™ paper and a modified differential nonorganic extraction method from spermatozoa containing mixed

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46

Yoshida, Kanako. "Analysis of DNA polymorphisms for human identification." Kyoto University, 2000. http://hdl.handle.net/2433/181418.

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Ko, Ming-him. "A multi-agent model for DNA analysis /." Hong Kong : University of Hong Kong, 1999. http://sunzi.lib.hku.hk/hkuto/record.jsp?B21949116.

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Joseph, Ansamma K. "DNA sequence analysis of T cell receptors." Thesis, University of Bath, 1996. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.321849.

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Baccouche, Alexandre. "Functional analysis of artificial DNA reaction network." Thesis, Sorbonne Paris Cité, 2015. http://www.theses.fr/2015USPCB135/document.

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La gestion et transmission d’information au sein d’organismes vivants implique la production et le trafic de molécules via des voies de signalisation sutructurées en réseaux de réactions chimiques. Ces derniers varient selon leur forme, taille ainsi que la nature des molécules mises en jeu. Parmi eux, les réseaux de régulation génétiques nous ont servi de modèle pour le développement et la mise en place d’un système de programmation moléculaire in vitro. En effet, l’expression d’un gène est majoritairement dominé par des facteurs de transcription, autres protéines ou acides nucléiques, eux-mêm

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50

LAPI, MICHELA. "STRUCTURAL ANALYSIS OF TRANSCRIPTION FACTOR/DNA COMPLEXES." Doctoral thesis, Università degli Studi di Milano, 2021. http://hdl.handle.net/2434/834212.

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Binding of transcription factors (TFs) to discrete sequences in gene promoters and enhancers is crucial to the process by which genetic information is transferred to biological functions. TF structural analysis is the key to understanding their DNA-binding mode and for the design of specific inhibitors. In this context, the present PhD project focuses on two TFs: (1) NFIX, a TF with unknown structure that binds to the palindromic motif TTGGC(n5)GCCAA and plays an essential role in skeletal muscle development; and (2) NF-Y, a histone-like TF that binds the CCAAT box in promoters of cell cycle g

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