Gotowa bibliografia na temat „DNA damage”

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Artykuły w czasopismach na temat "DNA damage"

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Chakarov, Stoyan, Rumena Petkova, George Ch Russev, and Nikolai Zhelev. "DNA damage and mutation. Types of DNA damage." BioDiscovery 11 (February 23, 2014): e8957. https://doi.org/10.7750/BioDiscovery.2014.11.1.

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This review outlines the basic types of DNA damage caused by exogenous and endogenous factors, analyses the possible consequences of each type of damage and discusses the need for different types of DNA repair. The mechanisms by which a minor damaging event to DNA may eventually result in the introduction of heritable mutation/s are reviewed. The major features of the role of DNA damage in ageing and carcinogenesis are outlined and the role of iatrogenic DNA damage in human health and disease (with curative intent as well as a long-term adverse effect of genotoxic therapies) are discussed in d
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Mitra, Manu. "DNA Repairing and its Mechanism in the Cell." ACTA Scientific Medical Sciences 3, no. 8 (2019): 116–19. https://doi.org/10.5281/zenodo.3338556.

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DNA (Deoxyribonucleic Acid) repair denotes collection of processes by which a cell identifies and corrects the damage to the DNA molecules that encode its genome. Several incisions causes structural damage to the DNA molecule and may alter or eliminate the cell’s ability to transcribe the gene that are affected DNA encodes. There are many techniques and methods to repair DNA, however, in this paper few methods are reviewed. For instance – Mechanism for repairing damaged DNA, Novel technique to repair damaged DNA, Scientist confirm DNA repair, Repairing faulty genes to cure diseases
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Chakarov, Stoyan, Rumena Petkova, George Russev, and Nikolai Zhelev. "DNA damage and mutation. Types of DNA damage." BioDiscovery, no. 11 (February 23, 2014): 1. http://dx.doi.org/10.7750/biodiscovery.2014.11.1.

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Yeung, ManTek, and Daniel Durocher. "Engineering a DNA damage response without DNA damage." Genome Biology 9, no. 7 (2008): 227. http://dx.doi.org/10.1186/gb-2008-9-7-227.

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Bagchi, Srilata, and Pradip Raychaudhuri. "Damaged-DNA Binding Protein-2 Drives Apoptosis Following DNA Damage." Cell Division 5, no. 1 (2010): 3. http://dx.doi.org/10.1186/1747-1028-5-3.

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Wallace, Bret D., and R. Scott Williams. "Ribonucleotide triggered DNA damage and RNA-DNA damage responses." RNA Biology 11, no. 11 (2014): 1340–46. http://dx.doi.org/10.4161/15476286.2014.992283.

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Nawy, Tal. "DNA variants or DNA damage?" Nature Methods 14, no. 4 (2017): 341. http://dx.doi.org/10.1038/nmeth.4254.

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Chakarov, Stoyan, Rumena Petkova, George Ch Russev, and Nikolai Zhelev. "DNA damage and the circadian clock." BioDiscovery 13 (September 14, 2014): e8960. https://doi.org/10.7750/BioDiscovery.2014.13.1.

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The role of the circadian clock has already been demonstrated for virtually all physiological processes, but it was only recently shown that cells were more sensitive to DNA damage at specific times of the day; that the peak of synthesis of mRNA and proteins of genes coding for products involved directly or indirectly in DNA repair was differentially timed in different tissues; and that the growth of some types of cancer followed a circadian pattern. The paper reviews the specificities of the clockwork mechanism in living cells associated with repair of DNA damage with regards to its role in a
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Stokes, Matthew P., Ruth Van Hatten, Howard D. Lindsay, and W. Matthew Michael. "DNA replication is required for the checkpoint response to damaged DNA in Xenopus egg extracts." Journal of Cell Biology 158, no. 5 (2002): 863–72. http://dx.doi.org/10.1083/jcb.200204127.

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Alkylating agents, such as methyl methanesulfonate (MMS), damage DNA and activate the DNA damage checkpoint. Although many of the checkpoint proteins that transduce damage signals have been identified and characterized, the mechanism that senses the damage and activates the checkpoint is not yet understood. To address this issue for alkylation damage, we have reconstituted the checkpoint response to MMS in Xenopus egg extracts. Using four different indicators for checkpoint activation (delay on entrance into mitosis, slowing of DNA replication, phosphorylation of the Chk1 protein, and physical
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Chakarov, Stoyan, Rumena Petkova, and George Ch Russev. "DNA repair systems." BioDiscovery 13 (September 22, 2014): e8961. https://doi.org/10.7750/BioDiscovery.2014.13.2.

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This paper provides detailed insight into the mechanisms of repair of different types of DNA damage and the direct molecular players (enzymes repairing the damage or tagging the damaged site for further processing; damage sensor molecules; other signalling and effector molecules). The genetic bases of diseases and conditions associated with defective DNA repair are comprehensively reviewed, from the ''classic'' severe diseases such as xeroderma pigmentosum and Cockayne syndrome to the much more subtle UV sensitivity syndromes. The review analyses the basic molecular mechanisms underlying the r
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Rozprawy doktorskie na temat "DNA damage"

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Sunter, Nicola. "DNA Damage Responses." Thesis, University of Newcastle Upon Tyne, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.489314.

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The histone H2AX has been established as a reliable biomarker of DNA damage, becoming phosphorylated rapidly following damage in discrete foci which can be correlated with DNA DSB number. In the present study, the phosphorylation of H2AX was used as a marker of DNA DSB damage to compare and contrast the damage induced by ionizing radiation, the topo II poison, etoposide, and the topo II catalytic inhibitor, ICRF-193. To examine the DNA damage numbers at time-points in the 24 hours following exposure to these damaging agents. Topo lIP null cells were used to investigate the contribution of topo
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Fazendeiro, Marta Sofia Pereira Pingarilho. "DNA damage induced by acrylamide: roe of genetic polymorphisms in DNA damage levels." Doctoral thesis, Faculdade de Ciências Médicas. UNL, 2013. http://hdl.handle.net/10362/10000.

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RESUMO:Em 1994 a acrilamida (AA) foi classificada pela IARC como um provável cancerígeno para o homem. Para além da utilização de AA em numerosas aplicações industriais, a AA está também presente numa grande variedade de alimentos ricos em amido e processados a temperaturas elevadas. Esta exposição através da ingestão de produtos alimentares despoletou elevadas preocupações ao nível do risco para a saúde pública e poderá implicar um risco adicional para o aparecimento de cancro. A glicidamida (GA), o metabolito epóxido formado a partir da oxidação da AA provavelmente através do citocromo P450
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Håkansson, Pelle. "Ribonucleotide reductase and DNA damage." Doctoral thesis, Umeå universitet, Institutionen för medicinsk kemi och biofysik, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-706.

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A prerequisite for a multicellular organism to survive is the ability to correctly replicate and repair DNA while minimizing the number of heritable mutations. To achieve this, cells need a balanced supply of deoxyribonucleoside triphosphates (dNTPs), the precursors for DNA synthesis. The rate-limiting step in de novo biosynthesis of dNTPs is catalyzed by the enzyme ribonucleotide reductase (RNR). The classic eukaryotic RNR enzyme consists of a large and a small subunit. Together, these subunits form a heterotetrameric RNR complex. The larger subunit harbours active sites whereas the smaller s
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Håkansson, Pelle. "Ribonucleotide reductase and DNA damage /." Umeå : Medicinsk biokemi och biofysik, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-706.

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Johnstone, Elaine Claire. "Ifosfamide metabolism and DNA damage." Thesis, University of Newcastle Upon Tyne, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.264417.

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Aldosari, Sahar. "Assessment of DNA damage and DNA damage response and repair in dormancy-enriched leukemia cells." Thesis, University of Nottingham, 2017. http://eprints.nottingham.ac.uk/47257/.

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Acute myeloid leukaemia (AML) is a heterogeneous myeloid malignancy characterized by clonal expansion of abnormal/immature hematopoietic precursor cells in the bone marrow. A side compartment in the BM niche consists of abnormal, quiescent cells, which are called dormant leukemic initiating cells (DLICs). Patients with AML tend to respond well to remission induction chemotherapy, but relapse is common because current therapies cannot completely eradicate leukemic cells. It is widely accepted that CD34+CD38− DLICs are more resistant to chemotherapy and that they contribute to drug resistance an
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Yu, Emma Pei Kuen. "Mitochondrial DNA damage, dysfunction and atherosclerosis." Thesis, University of Cambridge, 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.648537.

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Farooq, Sabya. "Free radical induced oxidative DNA damage." Thesis, University of Leicester, 1997. http://hdl.handle.net/2381/30749.

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Oxidative DNA damage has been implicated in processes such as carcinogenesis, mutagenesis, ageing and cell death. Reactive oxygen species (ROS) such as superoxide (O2), hydrogen peroxide (H2O 2) and hydroxyl radical (OH*) are produced in mammalian cells as a result of aerobic metabolism. However excess generation of these species by endogenous or exogenous sources can result in damage to DNA, producing a large number of sugar and base lesions. In order to understand the biological consequences of such free radical induced damage it is essential to characterise and quantitate this damage. This
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Bykov, Vladimir J. "UV-induced DNA damage in humans /." Stockholm, 1999. http://diss.kib.ki.se/1999/91-628-3345-6/.

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Lampus, Daniele Jacopo. "Towards IR Probes of DNA Damage." Thesis, University of Nottingham, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.518828.

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Książki na temat "DNA damage"

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Mosammaparast, Nima, ed. DNA Damage Responses. Springer US, 2022. http://dx.doi.org/10.1007/978-1-0716-2063-2.

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Wolfram, Siede, Kow Yoke Wah, and Doetsch Paul W, eds. DNA damage recognition. Taylor & Francis, 2006.

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Kato, Takamitsu A., ed. DNA Damage Detection. Springer US, 2025. https://doi.org/10.1007/978-1-0716-4574-1.

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Dizdaroglu, Miral, and R. Stephen Lloyd, eds. DNA Damage, DNA Repair and Disease. Royal Society of Chemistry, 2020. http://dx.doi.org/10.1039/9781839160769.

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Dizdaroglu, Miral, and R. Stephen Lloyd, eds. DNA Damage, DNA Repair and Disease. Royal Society of Chemistry, 2020. http://dx.doi.org/10.1039/9781839162541.

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Laboratory, Cold Spring Harbor, ed. Biological responses to DNA damage. Cold Spring Harbor Laboratory Press, 2000.

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International Congress on DNA Damage and Repair (1st 1987 Rome, Italy). DNA damage and repair. Plenum Press, 1989.

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Nickoloff, Jac A., and Merl F. Hoekstra. DNA Damage and Repair. Humana Press, 1998. http://dx.doi.org/10.1385/0896033562.

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Nickoloff, Jac A., and Merl F. Hoekstra. DNA Damage and Repair. Humana Press, 1998. http://dx.doi.org/10.1385/089603500x.

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Nickoloff, Jac A., and Merl F. Hoekstra. DNA Damage and Repair. Humana Press, 2001. http://dx.doi.org/10.1385/1592590950.

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Części książek na temat "DNA damage"

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Speer, Tod W., Christin A. Knowlton, Michelle Kolton Mackay, et al. "DNA Damage." In Encyclopedia of Radiation Oncology. Springer Berlin Heidelberg, 2013. http://dx.doi.org/10.1007/978-3-540-85516-3_607.

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Durant, Stephen T. "DNA Damage." In Encyclopedia of Cancer. Springer Berlin Heidelberg, 2014. http://dx.doi.org/10.1007/978-3-642-27841-9_1669-7.

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Durant, Stephen T. "DNA Damage." In Encyclopedia of Cancer. Springer Berlin Heidelberg, 2017. http://dx.doi.org/10.1007/978-3-642-27841-9_1669-8.

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Douki, Thierry, and Jean Cadet. "DNA Damage." In Encyclopedia of Astrobiology. Springer Berlin Heidelberg, 2015. http://dx.doi.org/10.1007/978-3-662-44185-5_451.

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Cadet, Jean, and Thierry Douki. "DNA Damage." In Encyclopedia of Astrobiology. Springer Berlin Heidelberg, 2011. http://dx.doi.org/10.1007/978-3-642-11274-4_451.

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Plevani, Paolo. "DNA Damage." In Encyclopedia of Systems Biology. Springer New York, 2013. http://dx.doi.org/10.1007/978-1-4419-9863-7_724.

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Durant, Stephen T. "DNA Damage." In Encyclopedia of Cancer. Springer Berlin Heidelberg, 2014. http://dx.doi.org/10.1007/978-3-662-46875-3_1669.

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Douki, Thierry, and Jean Cadet. "DNA Damage." In Encyclopedia of Astrobiology. Springer Berlin Heidelberg, 2023. http://dx.doi.org/10.1007/978-3-662-65093-6_451.

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Durant, Stephen T. "DNA Damage." In Encyclopedia of Cancer. Springer Berlin Heidelberg, 2011. http://dx.doi.org/10.1007/978-3-642-16483-5_1669.

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Sharma, Bechan, and Nitika Singh. "DNA damage." In Environmental Damage to DNA and the Protective Effects of Phytochemicals. CRC Press, 2021. http://dx.doi.org/10.1201/9780429342059-10.

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Streszczenia konferencji na temat "DNA damage"

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Aso, T., S. Fukagawa, Y. Hirano, M. Hara, and S. Fujiwara. "Review and Strategy for Implementing Criteria of DNA Damage in an Atomistic Model using Geant4-DNA." In 2024 IEEE Nuclear Science Symposium (NSS), Medical Imaging Conference (MIC) and Room Temperature Semiconductor Detector Conference (RTSD). IEEE, 2024. http://dx.doi.org/10.1109/nss/mic/rtsd57108.2024.10658071.

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Prevenslik, Thomas. "DNA Damage by Nanoparticles." In ASME 2010 First Global Congress on NanoEngineering for Medicine and Biology. ASMEDC, 2010. http://dx.doi.org/10.1115/nemb2010-13198.

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Nanoparticles (NPs) have provided significant technological advancements including bactericidal agents in food processing, and treatment of cancer tumors. However, there is a darkside. Over the past decade, experiments [1,2] have shown NPs to be a health risk by inducing DNA damage that can lead to cancer.
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Becher, R., JA Holme, A. Solhaug, et al. "DNA Damage and DNA Damage Response Induced by Mould Spores and Mycotoxins." In American Thoracic Society 2009 International Conference, May 15-20, 2009 • San Diego, California. American Thoracic Society, 2009. http://dx.doi.org/10.1164/ajrccm-conference.2009.179.1_meetingabstracts.a3174.

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Kunina, E. I., A. V. Shernyukov, A. V. Yudkina, D. O. Zharkov, and E. G. Bagryanskya. "DETERMINATION OF THE SPATIAL STRUCTURE OF A DNA DUPLEX WITH A NON-COMPLEMENTARY CU PAIR BY NMR SPECTROSCOPY*." In XI МЕЖДУНАРОДНАЯ КОНФЕРЕНЦИЯ МОЛОДЫХ УЧЕНЫХ: БИОИНФОРМАТИКОВ, БИОТЕХНОЛОГОВ, БИОФИЗИКОВ, ВИРУСОЛОГОВ, МОЛЕКУЛЯРНЫХ БИОЛОГОВ И СПЕЦИАЛИСТОВ ФУНДАМЕНТАЛЬНОЙ МЕДИЦИНЫ. IPC NSU, 2024. https://doi.org/10.25205/978-5-4437-1691-6-131.

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DNA molecules are constantly being damaged. In human cells the amount of damage can reach several thousand per cell per day. This damage includes changes in the chemical structure of DNA, chain breakage or the presence of incorrect bases or their fragments. However, cells have repair systems to help repair these damages. The study of processes modeling DNA repair is an urgent task, since DNA damage is the cause of many diseases. DNA structures with AP sites can be used to develop drugs to treat tumors and other conditions.
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Rogers, Kim R., A. Apostol, and J. Cembrano. "Optical detection of DNA damage." In Photonics East (ISAM, VVDC, IEMB), edited by Tuan Vo-Dinh and Robert L. Spellicy. SPIE, 1999. http://dx.doi.org/10.1117/12.338987.

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Guo, Changhong, Yuwei Cao, Rui Li, Liang Si, Jun Ma, and Zening Yuan. "Nitrobenzene Induces DNA Damage in Tobacco." In 2010 4th International Conference on Bioinformatics and Biomedical Engineering (iCBBE 2010). IEEE, 2010. http://dx.doi.org/10.1109/icbbe.2010.5516350.

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Head, Pamelasara E., Hui Zhang, and David S. Yu. "Abstract A114: SIRT2 directs DNA-PKcs in the DNA damage response." In Abstracts: AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics; October 26-30, 2017; Philadelphia, PA. American Association for Cancer Research, 2018. http://dx.doi.org/10.1158/1535-7163.targ-17-a114.

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Dordevic, Milos, Konstantinos Chatzipapas, Ngoc Hoang Tran, et al. "Simulation of DNA damage using the “molecularDNA” example application of Geant4-DNA." In 2nd International Conference on Chemo and Bioinformatics. Institute for Information Technologies, University of Kragujevac, 2023. http://dx.doi.org/10.46793/iccbi23.144d.

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The scientific community has a large interest in the studies of DNA damage and response after exposure to ionizing radiation. Several in-silico methods have been proposed so far to model and study the mechanisms of DNA damage using Monte Carlo simulations. The “molecularDNA” example is one of the most recent applications to simulate the irradiation of human cancer cells and bacteria using Geant4-DNA. This example enables the simulation of the physical, physico-chemical and chemical stages of liquid water irradiation, including radiolytic processes following the particle irradiation of the pre-
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Ueno, Yuya, Shota Yamazaki, Hiromichi Hoshina та Masahiko Harata. "THz irradiation reduces the DNA damage marker γH2AX in human cells: THz wave enhances DNA damage repair?" У 2022 47th International Conference on Infrared, Millimeter and Terahertz Waves (IRMMW-THz). IEEE, 2022. http://dx.doi.org/10.1109/irmmw-thz50927.2022.9895933.

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Asadi, Mahmoud, Tyler Blair, Ben Kuiper, et al. "DNA Tracer Technology Applications in Hydraulic Fracturing Flowback Analyses." In SPE International Conference and Exhibition on Formation Damage Control. SPE, 2022. http://dx.doi.org/10.2118/208865-ms.

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Abstract A new and robust tracer technology, based on Nano-sized encapsulated silica DNA sequences is presented. This cutting-edge technology enables a bond of each DNA sequence to a magnetic core particle and encapsulates it with silica. Therefore, one can have infinite sequences of DNA tracers. Each DNA tracer, with its identity signature, can be easily identified and characterized with no interferences. Unique chemistry makes these DNA tracers, either water-wet or oil-wet. The water-wet tracers can be used in hydraulic fracturing to precisely and accurately analyze flowback, both qualitativ
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Raporty organizacyjne na temat "DNA damage"

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Kisby, Glen. DNA Damage Induced Neuronal Death. Defense Technical Information Center, 1999. http://dx.doi.org/10.21236/ada375640.

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Phoebe L. Stewart. Cryo-EM Imaging of DNA-PK DNA Damage Repair Complexes. Office of Scientific and Technical Information (OSTI), 2005. http://dx.doi.org/10.2172/841088.

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Sevilla, M. D. Mechanisms for radiation damage in DNA. Office of Scientific and Technical Information (OSTI), 1992. http://dx.doi.org/10.2172/7176057.

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Sevilla, M. D. Mechanisms for radiation damage in DNA. Office of Scientific and Technical Information (OSTI), 1990. http://dx.doi.org/10.2172/5018151.

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Green, Brian M. DNA Damage and Genomic Instability Induced by Inappropriate DNA Re-Replication. Defense Technical Information Center, 2005. http://dx.doi.org/10.21236/ada436928.

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Green, Brian M., and Joachim J. Li. DNA Damage and Genomic Instability Induced by Inappropriate DNA Re-replication. Defense Technical Information Center, 2007. http://dx.doi.org/10.21236/ada467931.

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Green, Brian. DNA Damage and Genomic Instability Induced by Inappropriate DNA Re-replication. Defense Technical Information Center, 2006. http://dx.doi.org/10.21236/ada482750.

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Scott, Kenneth L., and Sharon E. Plon. Alternative DNA Damage Checkpoint Pathways in Eukaryotes. Defense Technical Information Center, 2001. http://dx.doi.org/10.21236/ada396714.

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Wilson, David. Repair Machinery for Radiation-Induced DNA Damage. Defense Technical Information Center, 2001. http://dx.doi.org/10.21236/ada396847.

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Thompson, Lawrence H. Repair Machinery for Radiation-Induced DNA Damage. Defense Technical Information Center, 2002. http://dx.doi.org/10.21236/ada407373.

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