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Rozprawy doktorskie na temat „DNA methylation”

Autor: Grafiati

Data publikacji: 4 czerwca 2021

Data aktualizacji: 25 lipca 2025

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1

Tasanasuwan, Piyama. "Targeted DNA methylation." Thesis, University of Sheffield, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.251476.

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MacLeod, A. Robert (Robert Alan) 1966. "DNA methylation and oncogenesis." Thesis, McGill University, 1995. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=39956.

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DNA methylation is a postreplicative covalent modification of the DNA which is catalysed by the DNA methyltransferase enzyme. DNA methylation plays an important role in controlling the gene expression profile of mammalian cells. The hypothesis presented in this thesis is that the expression of the DNA methyltransferase gene is upregulated by cellular oncogenic pathways, and that this induction of MeTase activity results in DNA hypermethylation and plays a causal role in cellular transformation. Novel DNA methyltransferase inhibitors may inhibit the excessive activity of DNA methyltransferase i

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Tavares, de Araujo Felipe. "DNA replication and methylation." Thesis, McGill University, 2000. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=37847.

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One of the main questions of modern biology is how our cells interpret our genetic and epigenetic information. DNA methylation is a covalent modification of the genome that is essential for mammalian development and plays an important role in the control of gene expression, genomic imprinting and X-chromosome inactivation (Bird and Wolffe, 1999; Szyf et al., 2000). Furthermore, changes in DNA methylation and DNA methyltransferase 1 (DNMT1) activity have been widely documented in a number of human cancers (Szyf, 1998a; Szyf et al., 2000).<br>In Escherichia coli, timing and frequency of initiati

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Tsusaka, Takeshi. "Methylation of DNA Ligase 1 by G9a/GLP Recruits UHRF1 to Replicating DNA and Regulates DNA Methylation." Kyoto University, 2018. http://hdl.handle.net/2433/232305.

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Wong, Nicholas Chau-Lun. "DNA methylation at the neocentromere /." Connect to thesis, 2006. http://eprints.unimelb.edu.au/archive/00001883.

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Carrió, Gaspar Elvira. "DNA Methylation Dynamics during Myogenesis." Doctoral thesis, Universitat de Barcelona, 2015. http://hdl.handle.net/10803/296312.

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Myogenesis is the differentiation process which encompasses the formation of skeletal muscle during development, regeneration and tissue homeostasis throughout life. Arising from embryonic or adult stem cells, the myogenic process comprehends the acquisition of a specialized cell identity and the loss of pluri/multipotent and proliferative capacities. Starting with the hypothesis that DNA methylation, together with other epigenetic mechanisms and the transcription factors, orchestrates the transcriptional program, this thesis provides a comprehensive picture of DNA methylation dynamics during

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7

Akman, Kemal. "Bioinformatics of DNA Methylation analysis." Diss., Ludwig-Maximilians-Universität München, 2014. http://nbn-resolving.de/urn:nbn:de:bvb:19-182873.

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8

陳桂儀 and Kwai-yi Jacqueline Chan. "DNA methylation and pediatric cancer." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2002. http://hub.hku.hk/bib/B31970370.

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Ó, Riain Ciarán Liam. "DNA methylation in follicular lymphoma." Thesis, Queen Mary, University of London, 2010. http://qmro.qmul.ac.uk/xmlui/handle/123456789/1318.

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Follicular Lymphoma (FL) is a common B cell Non-Hodgkin Lymphoma with a median survival of 8-10 years. Patients frequently undergo transformation to a more aggressive lymphoma and this is associated with drastically reduced survival. The hallmark of FL is the t(14;18) translocation yet this alone is insufficient for lymphomagenesis. While a number of secondary genetic changes have been described, epigenetic studies have lagged behind. Epigenetics refers to mechanisms that alter gene expression without a change in the primary DNA sequence. DNA methylation was quantitatively profiled at 1505 CpG

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Gonçalves, Athanásio Camila. "DNA methylation in Daphnia magna." Thesis, University of Birmingham, 2016. http://etheses.bham.ac.uk//id/eprint/7140/.

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Daphnia magna is gaining interest as a model for epigenetic research. It is easy to maintain under laboratory conditions and has low genetic diversity due to parthenogenetic reproduction. The D. magna genome is responsive to a wide range of stimuli and genomics resources are being developed for this species. Despite these great advantages, information regarding the epigenome of D. magna and its regulation is still lacking. Thus, the main aim of this work was to describe the methylome of D.magna and investigate its regulation and responsiveness to environmentally relevant exposure conditions. D

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11

McArthur, Michael. "Chromatin structure and DNA methylation." Thesis, University of Cambridge, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.627534.

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Hunter, Jennifer Margaret. "Reprogramming a DNA methylation mutant." Thesis, University of Edinburgh, 2016. http://hdl.handle.net/1842/25874.

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Chemical modification of the cytosine base via the addition of a methyl group to form 5-‐methylcytosine (5-‐mC) is a well-‐studied example of an epigenetic mark, which contributes to regulation of gene expression, chromatin organisation and other such cellular processes without affecting the underlying DNA sequence. In recent years it was shown that 5-‐mC is not the only DNA modification found within the vertebrate genome. 5-‐hydroxymethylcytosine (5-‐hmC) was first described in 1952 although it wasn’t until 2009 when it was rediscovered in mammalian tissues that it sparked intense inter

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Chan, Kwai-yi Jacqueline. "DNA methylation and pediatric cancer." Hong Kong : University of Hong Kong, 2002. http://sunzi.lib.hku.hk/hkuto/record.jsp?B2515526x.

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Melquist, Stacey Michelle. "DNA methylation signaling in Arabidopsis." Available to US Hopkins community, 2002. http://wwwlib.umi.com/dissertations/dlnow/3068188.

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Poli, Elena. "DNA METHYLATION ANALYSIS IN RHABDOMYOSARCOMA." Doctoral thesis, Università degli studi di Padova, 2016. http://hdl.handle.net/11577/3424380.

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Rhabdomyosarcoma (RMS) is a highly aggressive pediatric soft-tissue sarcoma. It is mainly classified into two major subtypes characterized by alveolar (ARMS) and embryonal (ERMS) histologies. ARMS are characterized by a more aggressive behavior with a higher tendency to present metastasis at diagnosis and to relapse after treatment. Approximately 80% of ARMS harbour the reciprocal chromosomal translocation t(2;13)(q35;q14) and, less commonly, the variant translocation t(1;13)(p36;q14), in which PAX3 and FOXO1, or PAX7 and FOXO1 genes, respectively, are juxtaposed. Unfortunately, no such specif

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Gould, Poppy Aeron. "The role of DNA repair in DNA methylation dynamics." Thesis, University of Cambridge, 2018. https://www.repository.cam.ac.uk/handle/1810/274360.

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The mammalian epigenome is globally reprogrammed at two stages of development; this involves the erasure and re-establishment of DNA methylation by both passive and active mechanisms, including DNA repair pathways, and occurs concurrently with an increase in developmental potency. In addition to Uhrf1 and the Tet enzymes, the interplay between activation induced cytidine deaminase (AID) and the DNA repair machinery has been implicated in epigenetic reprogramming of various in vivo and in vitro systems including mouse primordial germ cells, zygotes and induced pluripotent stem cells. AID deamin

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Tan, Choon Ping. "Control of mammalian DNA methylation system components by protein arginine methylation." Thesis, University College London (University of London), 2006. http://discovery.ucl.ac.uk/1445922/.

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DNA methylation is essential for the survival and development of vertebrates. Methylated cytosine in the context of CpG-dinucleotides within the genome is recognized by proteins from the methyl-CpG DNA binding domain (MBD) family. When bound to methyl-CpG DNA, most MBD proteins can recruit histone deacetylase (HDAC) silencing complexes to the site of chromatin to remodel its structure, and this causes transcription repression. Loss of CpG-DNA methylation results in embryonic lethality in mice, but loss of methyl-CpG DNA recognizing MBD proteins produce a viable phenotype. Our interest in MBD p

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Hernando, Herráez Irene 1985. "Evolutionary insights into human DNA methylation." Doctoral thesis, Universitat Pompeu Fabra, 2015. http://hdl.handle.net/10803/392140.

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DNA methylation is a crucial epigenetic modification involved in numerous biological processes. However, despite its functional importance, the evolutionary history of this modification and the mechanisms diving such changes are poorly understood. The aim of this thesis is to provide a better understanding of DNA methylation in the context of human recent evolution. We identified and described hundreds of regions presenting a human-specific DNA methylation pattern compared to great apes. We also analyzed for the first time the relationship between DNA methylation changes and sequence evolution

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Mirbahai, Leda. "DNA methylation profiling of fish tumours." Thesis, University of Birmingham, 2012. http://etheses.bham.ac.uk//id/eprint/3633/.

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Assessment of disease status in fish is used as an indicator of the biological effects of contaminants in the marine environment. At some UK offshore sites the prevalence of liver tumours in Limanda limanda (dab) exceeds 20%. However, the molecular mechanisms of tumour formation and the causative agents are not known. The contribution of epigenetic mechanisms, although well-established in human tumourigenesis, is under-studied in tumours of aquatic species. In this thesis, alteration in the DNA methylation patterns in tumours of two fish species, the model species zebrafish (Danio rerio) and t

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Chan, Michelle M. (Michelle Mei Wah). "DNA methylation in early mammalian development." Thesis, Massachusetts Institute of Technology, 2013. http://hdl.handle.net/1721.1/81580.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Computational and Systems Biology Program, 2013.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references.<br>All the cells in the body contain the same genome yet showcase drastically different phenotypes. This is the result of different transcriptional programs, which are partly controlled by epigenetic modifications, including DNA methylation. In this thesis, I analyze genome-scale DNA methylation profiles across pre-implantation development to identify the targets and characterize the dynamics of global demethyl

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21

Patel, Yogen. "DNA methylation analysis of Alzheimer's disease." Thesis, King's College London (University of London), 2013. https://kclpure.kcl.ac.uk/portal/en/theses/dna-methylation-analysis-of-alzheimers-disease(f66ad885-3fdd-4c12-a73a-921cc31ccac2).html.

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There is evidence for a role for epigenetic mechanisms in Alzheimer's disease (AD), the most common age-dependent neurodegenerative disorder. The most studied epigenetic mark DNA methylation -the addition of a methyl group to cytosines located in CpG dinucleotides (5mC) - is known to change with aging and may reflect subtle changes in gene expression. Recently a second type of modified cytosine - a hydroxylated and methylated form (5hmC) - has been detected in the brain and maybe linked to the regulation of gene expression. Case-control differences in post-mortem brain DNA methylation were sou

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22

Currie, Graeme M. "DNA methylation at cytosine position 5." Thesis, Aston University, 1992. http://publications.aston.ac.uk/12603/.

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DNA methylation appears to be involved in the regulation of gene expression. Transcriptionally inactive (silenced) genes normally contain a high proportion of 5-methyl-2'-deoxycytosine residues whereas transcriptionally active genes show much reduced levels. There appears good reason to believe that chemical agents capable of methylating 2'-deoxycytosine might affect gene expression and as a result of hypermethylating promoter regions of cytosine-guanine rich oncogenic sequences, cancer related genes may be silenced. This thesis describes the synthesis of a number of `electrophilic' S-methylsu

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23

Warnecke, Peter. "DNA methylation in early mammalian development." Thesis, The University of Sydney, 1998. https://hdl.handle.net/2123/27569.

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In mammalian genomes, the base cytosine is frequently modified to S-methylcytosine by the action of DNA methyltransferases. DNA methylation may affect gene expression within the cell by acting to repress transcription, and has been suggested to be involved in numerous cellular processes including tissue-specific gene control, repression of transposon activity, X-chromosome inactivation, genomic imprinting and tumourigenesis. While the pattern of mammalian DNA methylation is typically stable in the adult, widespread changes occur to genomic methylation levels during embryonic development

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24

Mischke, Mona. "DNA methylation of the POMC gene." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2012. http://dx.doi.org/10.18452/16456.

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Adipositas ist eine polymorphe chronische Erkrankung mit epidemischer Prävalenz. Im katabolen Leptin-Melanocortin-Signalweg ist das Proopiomelanocortin Gen (POMC) ein zentrales Element, das bei Dysfunktion massive Adipositas bewirken kann. Auch eine kürzlich identifizierte intragenische Methylierungsvariante des POMC wurde mit Adipositas assoziiert und deutet somit auf eine mögliche epigenetische Modulation des Gewichtsphänotyps hin. Zur Aufklärung der Relevanz, Stabilität und Entwicklung dieser epigenetischen Modifikation wurden die Funktionalität, Ontogenese und Phylogenese der POMC DNA-Meth

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Aguirre-Arteta, Ana Maria. "Regulation of DNA methylation during development." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2000. http://dx.doi.org/10.18452/14509.

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Die DNA Methyltransferasen sind verantwortlich für die spezifische Methylierung von DNA-Basen. Mehrere DNA Methyltransferasen sind bekannt, wobei die Dnmt1 das hauptsächlich vorkommende Enzym ist. Bei Säugetieren korreliert die DNA-Methylierung mit der Genaktivität und ist essentiell für die Embryonalentwicklung. Eine beeinträchtigte Funktion oder Verfügbarkeit des Enzyms kann zu pathologisch veränderten Zuständen führen. Die Regulation der Dnmt1 und die damit verbundene Bedeutung bei der Entstehung von Krankheiten ist bisher nur unvollständig untersucht. In der Frühphase der Embryonalentwickl

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Ibrahim, Abdulkhaleg. "Regulation of DNA methylation by DNA glycosylases MBD4 and TDG." Thesis, Strasbourg, 2015. http://www.theses.fr/2015STRAJ019/document.

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Chez les mammifères, la méthylation est une marque épigénétique ciblant la cytosine principalement dans un contexte CpG pour produire une 5mC. 5mC est très sensible à une déamination spontanée ou enzymatique, conduisant à la formation d'un mésappariement G/T. La 5mCpeut également être oxydée pour former successivement la 5hmC, la 5fC et la 5caC. Ces modifications de la 5mC participent aux processus actifs de déméthylation de l’ADN. Chez les mammifères, la thymine, dans le mésappariement G/T, est clivée par TDG et MBD4. TDG est également en mesure d'exciser 5fC et 5caC. Cette thèse avait pour b

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Bonk, Aaron James. "DNA methylation in the early porcine embryo." Diss., Columbia, Mo. : University of Missouri-Columbia, 2007. http://hdl.handle.net/10355/4885.

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Thesis (Ph.D.)--University of Missouri-Columbia, 2007.<br>The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file. Title from title screen of research.pdf file (viewed on March 23, 2009) Vita. Includes bibliographical references.

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Pichler, Garwin. "Crosstalk between DNA methylation and histone modifications." Diss., lmu, 2012. http://nbn-resolving.de/urn:nbn:de:bvb:19-143799.

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Chik, Pui Chi Flora. "Targeting the DNA methylation machinery in cancers." Thesis, McGill University, 2013. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=114316.

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Cancer cells have aberrant DNA methylation patterns which are characterized by hypomethylation of a large set of promoters and hypermethylation of tumor suppressor genes. The dynamic nature of the epigenome makes it a valuable target for therapeutic interventions. This thesis focuses on understanding the use of various inhibitors towards DNA methylation-related proteins and their respective anti-cancer activities at both global and gene-specific levels. The widely used demethylating agent 5-azacytidine and 5-aza-2'-deoxycytidine (5-azaCdR) are FDA-approved drugs for the treatment of myelodyspl

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Mohamed, Noor Dzul Azri. "DNA methylation in paediatric germ cell tumours." Thesis, University of Nottingham, 2013. http://eprints.nottingham.ac.uk/27671/.

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Germ cell tumours (GeTs)affect both paediatric and adult populations, and can occur either in gonadal or extragonadal regions along the body's ventral midline. These tumours can be broadly categorized into two subgroups, seminomatous (SEM) or nonseminomatous (N-SEM). The latter can be further subcategorized into embryonal carcinoma (EC), teratoma, yolk sac tumour (YST) and choriocarcinoma (eC) according to their differentiation. As in many other tumours, DNA methylation has been proposed to be involved in GCTdevelopment. However to date, most studies were performed using adult testicular GCTs.

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Gentry, Matthew Steven. "Novel DNA methylation targets in Arabidopsis thaliana." Thesis, University of Leeds, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.590486.

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The initiation of DNA methylation in Arobidopsis is controlled by the RNA-directed DNA methylation (RdDM) pathway that uses 24nt siRNAs to recruit the de novo methyltransferase DRM2 to the target site. The REPETITIVE PETUNIA SEQUENCE (RPS) acts as a hot spot for de novo methylation, in particular, hypermethylation is found at a 62 nt region containing an 11 nt palindromic sequence with an 18 nt spacer that forms a putative stem loop structure. The analysis of deletion/substitution derivatives of RPS showed that de novo methylation did not depend on the DNA sequences in the loop region, but did

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Loughery, Jayne Eleanor Patricia. "Mismatch repair, DNA methylation and cell death." Thesis, University of Ulster, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.551565.

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Mismatch repair is a vital DNA repair mechanism whose absence leads to a tolerance towards mutations and a predisposition to colon cancer. MLHl is one of the main proteins involved and is highly conserved from E. coli to human. It not only plays a role in repair, but can signal the cell to die if damage levels become too high. The mechanism by which MLHl triggers cell death in response to damage is not entirely clear, and is likely to differ between normal and cancerous cells. Previous work in the Walsh lab had generated MLH1-depleted subclones of a telomerase- immortalised normal human fibrob

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McNamara, Andrew Raeburn. "Targeted methylation at CpG sites on DNA." Thesis, King's College London (University of London), 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.271360.

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Dang, Mary Anh Ngoc. "DNA methylation signature in type 1 diabetes." Thesis, Queen Mary, University of London, 2015. http://qmro.qmul.ac.uk/xmlui/handle/123456789/12791.

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Type 1 diabetes is an autoimmune disease due to the interaction of genetic and non-genetic factors, leading to an immune response against insulin secreting islet cells. Concordance rates for type 1 diabetes in monozygotic twins vary widely and no single environmental factor has been shown to cause the disease. Therefore, epigenetics has been suggested to play a role in diabetes aetiology. Preliminary results identified DNA methylation changes in CD14+ monocytes from childhood-onset type 1 diabetes which antedated the disease. Following on from this work, this present study was carried out to i

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Ghorbani, Mohammadmersad. "Computational analysis of CpG site DNA methylation." Thesis, Brunel University, 2013. http://bura.brunel.ac.uk/handle/2438/8217.

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Epigenetics is the study of factors that can change DNA and passed to next generation without change to DNA sequence. DNA methylation is one of the categories of epigenetic change. DNA methylation is the attachment of methyl group (CH3) to DNA. Most of the time it occurs in the sequences that G is followed by C known as CpG sites and by addition of methyl to the cytosine residue. As science and technology progress new data are available about individual’s DNA methylation profile in different conditions. Also new features discovered that can have role in DNA methylation. The availability of new

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Castillo-Fernandez, Juan Edgar. "Genetic and environmental influences on DNA methylation." Thesis, King's College London (University of London), 2018. https://kclpure.kcl.ac.uk/portal/en/theses/genetic-and-environmental-influences-on-dna-methylation(37deaeb8-f3bd-4a4a-9765-d7d2f2184bf6).html.

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Epigenetic mechanisms respond to both genetic and environmental factors, but these underlying effects are not yet fully characterized or completely understood. In this thesis I used twins as a tool for evaluating the effect of genetic and environmental impacts on DNA methylation, a well-known epigenetic mechanism. DNA methylation was studied on a genome-wide scale in human blood samples with a combination of bioinformatics, computational, and statistical approaches. First, genetic influences on DNA methylation profiles were assessed by estimation of the heritability of DNA methylation and iden

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Termanis, Ausma. "Regulators of DNA methylation in mammalian cells." Thesis, University of Edinburgh, 2013. http://hdl.handle.net/1842/11749.

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Although the many cells within a mammal share the same DNA sequence, their gene expression programmes are highly heterogeneous, and their functions correspondingly diverse. This heterogeneity within an isogenic population of cells arises in part from the ability of each cell to respond to its immediate surroundings via a network of signalling pathways. However, this is not sufficient to explain many of the transcriptional and functional differences between cells, particularly those that are more stable, or, indeed, differences in expression between parental alleles within the same cell. This c

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Piccolo, Francesco M. "Reversing DNA methylation by heterokaryon-mediated reprogramming." Thesis, Imperial College London, 2013. http://hdl.handle.net/10044/1/14505.

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Genomic imprinting directs the allele‐specific expression of a subset of loci according to their parental origin. Monoallelic expression of these genes is regulated by imprinting control regions (ICRs) and is established in the embryonic germ line through differential DNA methylation. Differentiated cells can be reprogrammed to pluripotency by several strategies including the ectopic expression of specific ‘inducers’ and by transfer of nuclei into enucleated eggs. Cellular fusion of somatic cells with a pluripotent stem cell partner can also lead to dominant pluripotent reprogramming. Although

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Albertsen, Maria. "Regulation of PAX6: DNA methylation and MicroRNAs." Thesis, Edith Cowan University, Research Online, Perth, Western Australia, 2016. https://ro.ecu.edu.au/theses/1793.

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The Paired box gene 6 (PAX6) is a tissue-specific transcription factor, which controls proliferation and differentiation processes of embryonic- and adult progenitor cells. Consequently, dysregulation of PAX6 can cause cancer and a tight regulation is essential. The present thesis focuses on two mechanisms for regulation of PAX6, which are microRNAs (Study 1) and DNA methylation (Study 2 and Study 3), respectively. Study 1 examines three predicted microRNA-7 (miR-7) target sites within the 3'untranslated region (3'UTR) of the human PAX6 gene. A Luciferase reporter assay demonstrates that two o

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Leung, Danny Chi Yeu. "Transcriptional silencing of endogenous retroviruses : interplay between histone H3K9 methylation and DNA methylation." Thesis, University of British Columbia, 2011. http://hdl.handle.net/2429/38966.

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Endogenous retroviruses (ERVs) are found in genomes of all higher eukaryotes. As retrotransposition is deleterious, pathways have evolved to repress these retroelements. While DNA methylation transcriptionally represses ERVs in differentiated cells, this epigenetic mark is dispensable for maintaining proviral silencing during early stages of mouse embryogenesis and in embryonic stem cells (mESCs). Studies in diverse species have found histone H3K9 methylation and DNA methylation to function together to repress retrotransposons. However, until recently, little was known about the role of this h

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Milicic, Lidija. "Peripheral DNA methylation patterns, methylation age and Alzheimer’s disease risk and related phenotypes." Thesis, Edith Cowan University, Research Online, Perth, Western Australia, 2024. https://ro.ecu.edu.au/theses/2763.

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Background Dementia, including Alzheimer’s disease (AD), is a significant global health challenge, ranked as the seventh leading cause of death with nearly 10 million new cases annually. Despite recent advancements in anti-amyloid therapies such as aducanumab, lecanemab and donenamab, targeting AD in its symptomatic stages has often yielded limited success due to advanced neurodegeneration. Early intervention is crucial for effective treatment, making precise early diagnosis imperative. The current diagnostic process for AD often lacks biomarker support, leading to misdiagnosis rates of around

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Model, Fabian. "Statistical analysis of microarray based DNA methylation data." [S.l.] : [s.n.], 2007. http://opus.kobv.de/tuberlin/volltexte/2007/1612.

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Cole, Lauren. "The Effect of the Microbiome on DNA Methylation." Master's thesis, Temple University Libraries, 2017. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/476093.

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Cancer Biology & Genetics<br>M.S.<br>DNA methylation is an epigenetic mark with profound impact on gene expression and regulation. It is known to be altered both in cancer and throughout aging. These aging and cancer related changes are characterized by hyper-methylation of normally unmethylated CpG islands, and global DNA hypomethylation. Microbiota-free mice are known to live longer than their normal counterparts, and microbial dysbiosis is known to be a hallmark of colorectal cancer. In order to determine the microbiota’s ability to impact DNA methylation patterns, that in turn may influenc

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Taplin, Christopher David. "Epigenetic profiling of bronchial epithelial cells : DNA methylation." Thesis, University of British Columbia, 2010. http://hdl.handle.net/2429/23483.

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Epigenetic regulation of gene expression is critical for normal human development and cellular differentiation. Although each somatic cell in the human body is genetically identical, epigenetic marks including the DNA methylation pattern are tissue-specific and critical for determining the vast array of cellular phenotypes. For studying respiratory disease, the airway epithelium is the ideal target tissue since it is the first point of contact for inhaled particles, viruses and airborne allergens. Cultured airway epithelial cells of asthmatic children show striking phenotypic differences compa

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Boisvert, François-Michel. "A role for arginine methylation in DNA repair /." Thesis, McGill University, 2005. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=85887.

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Arginine methylation is a post-translational modification occurring in higher eukaryotes that results in the addition of one or two methyl group on the nitrogen in the side chain of arginines. The enzymes responsible for protein arginine methylation have been classified in three groups. Type I enzymes promote the formation of both NG-monomethylated and asymmetric o-NG,NG-dimethylated arginines (aDMA). Type II enzymes catalyze the formation of monomethylated and symmetrical o-N G,N'G-dimethylated arginines (sDMA). The type III enzyme found in yeast catalyzes the monomethylation of the de

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Lucifero, Diana. "Developmental regulation of genomic imprinting by DNA methylation." Thesis, McGill University, 2004. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=85573.

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Maintaining appropriate patterns of gene expression in the gametes and during early embryogenesis is essential for normal development. DNA methylation is an epigenetic means of regulating gene expression and is an important molecular mark regulating the sex-specific expression of genes subject to genomic imprinting. Imprinted genes are expressed from only one of two inherited chromosomes and are differentially marked during gametogenesis to allow for their parental allele specific expression. These genes affect embryo growth, placental function, behavior after birth and are implicated i

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Athanasiadou, Rodoniki. "Establishment of DNA methylation patterns during mouse development." Thesis, University of Edinburgh, 2007. http://hdl.handle.net/1842/2390.

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Methylation is the only known modification of DNA and in animals it mainly occurs at cytosines in a CpG context. The pattern of DNA methylation varies among organisms; some invertebrates are totally devoid of it, while others have densely methylated regions embedded in an otherwise unmethylated genome. The genome of mammals on the other hand, is very rich in DNA methylation with the exception of regions with high CpG frequency, known as CpG islands, that are often found devoid of methylation. Little is known about the factors that determine the genome-wide pattern of DNA methylation. Moreover,

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Blair, John. "DNA methylation studies of preeclampsia and related conditions." Thesis, University of British Columbia, 2013. http://hdl.handle.net/2429/44801.

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Preeclampsia is a leading cause of maternal and fetal death throughout the world. It is caused by placental dysfunction and clinically characterized by hypertension and other adverse outcomes. Early-onset preeclampsia (EOPET) is a severe form of the disorder. Despite much investigation, the underlying biology of EOPET is unclear. It is known that disrupted oxygen delivery and altered cellular differentiation are characteristics of preeclampsia placentas, and that this likely has an effect on the placental molecular profile. This thesis primarily investigates DNA methylation, a key component in

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Jones, Sinead B. "DNA methylation of a mouse thymidine kinase gene." Thesis, Queen's University Belfast, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.356868.

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Furci, Leonardo. "The role of DNA methylation in Arabidopsis immunity." Thesis, University of Sheffield, 2017. http://etheses.whiterose.ac.uk/18746/.

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