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Artykuły w czasopismach na temat „DNA methylation”

Autor: Grafiati

Data publikacji: 4 czerwca 2021

Data aktualizacji: 25 lipca 2025

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1

Dang, Pengtao, Xiao Wang, Haiqi Zhu, et al. "Abstract 5352: Targeting DNA methylation in T cells to improve the efficacy of immunotherapy." Cancer Research 83, no. 7_Supplement (2023): 5352. http://dx.doi.org/10.1158/1538-7445.am2023-5352.

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Abstract T-cells are critical mediators of immunity and immunologic memory. Their cell fates are regulated in part through epigenetic mechanisms, including DNA methylation. Recent genome-wide methylation analyses have revealed dynamic alterations in the methylome at various stages of development and differentiation of T cells. At single cell level, it is not easy to simultaneously collect RNA-seq and RBBS methylation profiling. An important task is to understand the expression change of which genes and pathways are regulated by DNA methylations, especially for the ones that are associated with

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KARAASLAN, Ezgi, Ceren ACAR, and Şükrü KARTALCI. "Şizofrenide Epigenetik Bakış Açısı: DNA Metilasyon Modelleri." Arşiv Kaynak Tarama Dergisi 31, no. 3 (2022): 204–12. http://dx.doi.org/10.17827/aktd.1096901.

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Schizophrenia is a mental disorder characterized by delusions, hallucinations and various behavioral disorders. Affecting approximately 1% of the world's population, schizophrenia not only affects patients, but also other members of the society. Genetic and environmental factors play roles in the etiology of the disorder.Genetics, neurodevelopmental disorder, drug use, urban life, alone or together can be counted as the factors that cause the disorder. Despite increasing studies in recent years, the factors causing the formation of schizophrenia have not been fully clarified and more research

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3

Mikaelsson, Mikael A., and Courtney A. Miller. "DNA methylation." Epigenetics 6, no. 5 (2011): 548–51. http://dx.doi.org/10.4161/epi.6.5.15679.

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4

Singal, Rakesh, and Gordon D. Ginder. "DNA Methylation." Blood 93, no. 12 (1999): 4059–70. http://dx.doi.org/10.1182/blood.v93.12.4059.

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Singal, Rakesh, and Gordon D. Ginder. "DNA Methylation." Blood 93, no. 12 (1999): 4059–70. http://dx.doi.org/10.1182/blood.v93.12.4059.412k40_4059_4070.

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6

Sermswan, R., S. Mongkolsuk, and S. Sirisinha. "Characterization of the Opisthorchis viverrini genome." Journal of Helminthology 65, no. 1 (1991): 51–54. http://dx.doi.org/10.1017/s0022149x00010439.

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ABSTRACTThe methylations of trematode genomic DNA were analyzed using restriction enzymes and Southern blot hybridization. Restriction enzymes MspI, HpaII, HhaI were used to probe CpG methylation while MboI, Sau3A, DpnI were used for A methylation. The results revealed that Opisthorchis viverrini, Fasciola gigantica and Gigantocotyle siamensis had neither CpG nor A methylations. The presence of highly repeated DNA elements was also demonstrated in O. viverrini genomic DNA.

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Vogelgsang, Lars, Azlan Nisar, Sebastian Alexander Scharf, et al. "Characterisation of Type II DNA Methyltransferases of Metamycoplasma hominis." Microorganisms 11, no. 6 (2023): 1591. http://dx.doi.org/10.3390/microorganisms11061591.

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Bacterial virulence, persistence and defence are affected by epigenetic modifications, including DNA methylation. Solitary DNA methyltransferases modulate a variety of cellular processes and influence bacterial virulence; as part of a restriction-modification (RM) system, they act as a primitive immune system in methylating the own DNA, while unmethylated foreign DNA is restricted. We identified a large family of type II DNA methyltransferases in Metamycoplasma hominis, comprising six solitary methyltransferases and four RM systems. Motif-specific 5mC and 6mA methylations were identified with

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8

Wang, Heng, Yumo Xie, Gaopo Xu, et al. "Abstract 5272: Aberrant DNA 5mC and 6mA methylations increase ACE2 expression in intestinal cancer cells susceptible to SARS-CoV-2 infection." Cancer Research 82, no. 12_Supplement (2022): 5272. http://dx.doi.org/10.1158/1538-7445.am2022-5272.

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Abstract Angiotensin converting enzyme II (ACE2) is the cellular receptor of SARS-CoV-2. At present, ACE2 receptor is considered to be the key component in the SARS-CoV-2 infection and transmitting in the host. Among the cancer patients with COVID-19, the gastrointestinal cancer is the second most prevalent. The MethyLight and QASM assays were used to evaluated the genomic DNA 5mC methylation, while the CviAII enzyme-based 6mA-RE-qPCR was applied to determine motif-specific DNA 6mA methylation. The 6mA and 5mC methylation analyses of the long interspersed nuclear elements 1 (LINE1) were used t

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Majchrzak-Celińska, A., M. Naskret-Barciszewska, M. Giel-Pietraszuk, W. Nowak, P. Śron, and A. Barciszewska. "P02.08.A The relations of focal and total DNA methylation in gliomas." Neuro-Oncology 24, Supplement_2 (2022): ii31. http://dx.doi.org/10.1093/neuonc/noac174.101.

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Abstract Background The role of epigenetic events in gliomagenesis is undoubtful. However, the role of specific pathological events is not so clear. It was shown that loss in total DNA methylation correlates with higher tumor malignancy and oxidative DNA damage. But promoter methylation of many genes was reported to be significant for gliomas’ malignancy and predictive for the treatment outcome. In carcinogenesis in general global DNA hypomethylation and focal hypermethylation coexist. The aim of our project was to evaluate the correlation between total DNA methylation and promoter methylation

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10

Huang, Yung-Hsin, Su Jianzhong, Yong Lei, et al. "DNA Epigenome Editing Using Crispr-Cas Suntag-Directed DNMT3A." Blood 128, no. 22 (2016): 2707. http://dx.doi.org/10.1182/blood.v128.22.2707.2707.

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Abstract DNA methylation, an epigenetic modification, has widespread effects on gene expression during development. However, our ability to assign specific function to regions of DNA methylation is limited by the poor correlation between global patterns of DNA methylation and gene expression. To overcome this barrier, we utilized nuclease-deactivated Cas9 protein fused to repetitive peptide epitopes (SunTag) recruiting multiple copies of antibody-fused de novo DNA methyltranferase 3A (DNMT3A) (CRISPR-Cas SunTag-directed DNMT3A) to amplify local DNMT3A concentration and to methylate genomic sit

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11

Wei, Zhen, Subbarayalu Panneerdoss, Santosh Timilsina, et al. "Topological Characterization of Human and Mouse m5C Epitranscriptome Revealed by Bisulfite Sequencing." International Journal of Genomics 2018 (June 13, 2018): 1–19. http://dx.doi.org/10.1155/2018/1351964.

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Background. Compared with the well-studied 5-methylcytosine (m5C) in DNA, the role and topology of epitranscriptome m5C remain insufficiently characterized. Results. Through analyzing transcriptome-wide m5C distribution in human and mouse, we show that the m5C modification is significantly enriched at 5′ untranslated regions (5′UTRs) of mRNA in human and mouse. With a comparative analysis of the mRNA and DNA methylome, we demonstrate that, like DNA methylation, transcriptome m5C methylation exhibits a strong clustering effect. Surprisingly, an inverse correlation between mRNA and DNA m5C methy

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Gonçalves, Ana Cristina, Raquel Alves, Inês Baldeiras, et al. "DNA Methylation Is Correlated with Oxidative Stress in Myelodysplastic Syndrome—Relevance as Complementary Prognostic Biomarkers." Cancers 13, no. 13 (2021): 3138. http://dx.doi.org/10.3390/cancers13133138.

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Oxidative stress and abnormal DNA methylation have been implicated in cancer, including myelodysplastic syndromes (MDSs). This fact leads us to investigate whether oxidative stress is correlated with localized and global DNA methylations in the peripheral blood of MDS patients. Sixty-six MDS patients and 26 healthy individuals were analyzed. Several oxidative stress and macromolecule damage parameters were analyzed. Localized (gene promotor) and global DNA methylations (5-mC and 5-hmC levels; LINE-1 methylation) were assessed. MDS patients had lower levels of reduced glutathione and total anti

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13

Okitsu, Cindy Yen, and Chih-Lin Hsieh. "DNA Methylation Dictates Histone H3K4 Methylation." Molecular and Cellular Biology 27, no. 7 (2007): 2746–57. http://dx.doi.org/10.1128/mcb.02291-06.

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ABSTRACT Histone lysine methylation and DNA methylation contribute to transcriptional regulation. We have previously shown that acetylated histones are associated with unmethylated DNA and are nearly absent from the methylated DNA regions by using patch-methylated stable episomes in human cells. The present study further demonstrates that DNA methylation immediately downstream from the transcription start site has a dramatic impact on transcription and that DNA methylation has a larger effect on transcription elongation than on initiation. We also show that dimethylated histone H3 at lysine 4

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14

Nitin, Mukesh. "DNA METHYLATION SEQUENCING: A PROMISING TOOL FOR PANCREATIC CANCER DIAGNOSIS." Indian Journal of Health Care Medical & Pharmacy Practice 5, no. 1 (2024): 103–11. http://dx.doi.org/10.59551/ijhmp/25832069/2024.5.1.140.

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Pancreatic cancer remains a deadly disease due to late diagnosis and limited treatment options. DNA methylation, a key epigenetic modification, plays a crucial role in cancer development and progression. Various research using DNA methylation patterns in pancreatic cancer tissues resulted in comparative evaluation of normal pancreas and cell lines resulted in the identification of potential biomarkers for diagnosis and therapy. During DNA methylation case studies led to identification 807 genes and 1505 CpG sites. Also, 289 differentially methylated CpG sites were also reported suggesting thei

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15

Wang, Mengchi, Kai Zhang, Vu Ngo, et al. "Identification of DNA motifs that regulate DNA methylation." Nucleic Acids Research 47, no. 13 (2019): 6753–68. http://dx.doi.org/10.1093/nar/gkz483.

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AbstractDNA methylation is an important epigenetic mark but how its locus-specificity is decided in relation to DNA sequence is not fully understood. Here, we have analyzed 34 diverse whole-genome bisulfite sequencing datasets in human and identified 313 motifs, including 92 and 221 associated with methylation (methylation motifs, MMs) and unmethylation (unmethylation motifs, UMs), respectively. The functionality of these motifs is supported by multiple lines of evidence. First, the methylation levels at the MM and UM motifs are respectively higher and lower than the genomic background. Second

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16

Whalley, Katherine. "Dynamic DNA methylation." Nature Reviews Neuroscience 8, no. 5 (2007): 323. http://dx.doi.org/10.1038/nrn2133.

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Meissner, Alexander. "Guiding DNA Methylation." Cell Stem Cell 9, no. 5 (2011): 388–90. http://dx.doi.org/10.1016/j.stem.2011.10.014.

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Stower, Hannah. "Dynamic DNA methylation." Nature Reviews Genetics 13, no. 2 (2012): 75. http://dx.doi.org/10.1038/nrg3156.

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Muers, Mary. "Disentangling DNA methylation." Nature Reviews Genetics 14, no. 8 (2013): 519. http://dx.doi.org/10.1038/nrg3535.

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Issa, Jean-Pierre J., and Hagop M. Kantarjian. "Targeting DNA Methylation." Clinical Cancer Research 15, no. 12 (2009): 3938–46. http://dx.doi.org/10.1158/1078-0432.ccr-08-2783.

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Altaf, Adil, and Ahmad Zada. "DNA METHYLATION IN PLANTS." Journal of Global Innovations in Agriculture Sciences 9, no. 3 (2021): 109–14. http://dx.doi.org/10.22194/jgias/9.954.

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Common DNA methylation controls gene expression and preserves genomic integrity. Mal methylation can cause developmental abnormalities in the plants. Multiple enzymes carrying out de novo methylation, methylation maintenance, and active demethylation culminate in a particular DNA methylation state. Next-generation sequencing advances and computational methods to analyze the data. The model plant Arabidopsis thaliana was used to study DNA methylation patterns, epigenetic inheritance, and plant methylation. Plant DNA methylation research reveals methylation patterns and describing variations in

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Rao, Xiaolan, Shengli Yang, Shiyou Lü, and Pingfang Yang. "DNA Methylation Dynamics in Response to Drought Stress in Crops." Plants 13, no. 14 (2024): 1977. http://dx.doi.org/10.3390/plants13141977.

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Drought is one of the most hazardous environmental factors due to its severe damage on plant growth, development and productivity. Plants have evolved complex regulatory networks and resistance strategies for adaptation to drought stress. As a conserved epigenetic regulation, DNA methylation dynamically alters gene expression and chromosome interactions in plants’ response to abiotic stresses. The development of omics technologies on genomics, epigenomics and transcriptomics has led to a rapid increase in research on epigenetic variation in non-model crop species. In this review, we summarize

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Li, W., A. Van Soom, and L. Peelman. "Repeats as global DNA methylation marker in bovine preimplantation embryos." Czech Journal of Animal Science 62, No. 2 (2017): 43–50. http://dx.doi.org/10.17221/29/2016-cjas.

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DNA methylation undergoes dynamic changes and is a crucial part of the epigenetic regulation during mammalian early development. To determine the DNA methylation levels in bovine embryos, we applied a bisulfite sequencing based method aimed at repetitive sequences including three retrotransposons (L1_BT, BovB, and ERV1-1-I_BT) and Satellite I. A more accurate estimate of the global DNA methylation level compared to previous methods using only one repeat sequence, like Alu, could be made by calculation of the weighted arithmetic mean of multiple repetitive sequences, considering the copy number

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Osakabe, Akihisa, Fumiya Adachi, Yasuhiro Arimura, Kazumitsu Maehara, Yasuyuki Ohkawa, and Hitoshi Kurumizaka. "Influence of DNA methylation on positioning and DNA flexibility of nucleosomes with pericentric satellite DNA." Open Biology 5, no. 10 (2015): 150128. http://dx.doi.org/10.1098/rsob.150128.

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DNA methylation occurs on CpG sites and is important to form pericentric heterochromatin domains. The satellite 2 sequence, containing seven CpG sites, is located in the pericentric region of human chromosome 1 and is highly methylated in normal cells. In contrast, the satellite 2 region is reportedly hypomethylated in cancer cells, suggesting that the methylation status may affect the chromatin structure around the pericentric regions in tumours. In this study, we mapped the nucleosome positioning on the satellite 2 sequence in vitro and found that DNA methylation modestly affects the distrib

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Cusack, Martin, and Paul Scotting. "DNA methylation in germ cell tumour aetiology: current understanding and outstanding questions." REPRODUCTION 146, no. 2 (2013): R49—R60. http://dx.doi.org/10.1530/rep-12-0382.

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Germ cell tumours (GCTs) are a diverse group of neoplasms that can be histologically subclassified as either seminomatous or non-seminomatous. These two subtypes have distinct levels of differentiation and clinical characteristics, the non-seminomatous tumours being associated with poorer prognosis. In this article, we review how different patterns of aberrant DNA methylation relate to these subtypes. Aberrant DNA methylation is a hallmark of all human cancers, but particular subsets of cancers show unusually high frequencies of promoter region hypermethylation. Such a ‘methylator phenotype’ h

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Naiyar, Azmi, and shahid Ayesha. "Methylation status of potential genes in breast cancer patients and correlate them with gene expression." World Journal of Advanced Research and Reviews 17, no. 1 (2023): 815–24. https://doi.org/10.5281/zenodo.8080730.

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Breast cancer is one of the world’s most prevalent cancer among women. Globally approximately 2.3 million women are diagnosed with breast cancer in 2020. It arises due to epigenetic modification which outlooks aberrant methylation as its major cause. The methylation of DNA involves a covalent chemical modification which is one of the major drawback, promoting development of breast cancer. In addition, evidence and investigation suggest that these methylations at promoter region of CpG islands leads to silencing of gene associated with tumor suppressor which is involved in crucial gene ex

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Saadatmand, Forough, Muneer Abbas, Victor Apprey, Krishma Tailor, and Bernard Kwabi-Addo. "Sex differences in saliva-based DNA methylation changes and environmental stressor in young African American adults." PLOS ONE 17, no. 9 (2022): e0273717. http://dx.doi.org/10.1371/journal.pone.0273717.

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Background Low socioeconomic status neighborhood exposure to stress and violence may be sources of negative stimuli that poses significant health risks for children, adolescents and throughout the life course of an individual. The study aims to investigate if aberrant epigenetic DNA methylation changes may be a potential mechanism for regulating neighborhood exposures and health outcomes. Methods Exposure to environmental stressors identified in 98 young African American (AA) adults aged 18–25 years old from the Washington D.C., area were used in the study. We correlated the association betwee

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CAPLAKOVA, VERONIKA, EVA BABUSIKOVA, EVA BLAHOVCOVA, TOMAS BALHAREK, MARIA ZELIESKOVA, and JOZEF HATOK. "DNA Methylation Machinery in the Endometrium and Endometrial Cancer." Anticancer Research 36, no. 9 (2016): 4407–20. http://dx.doi.org/10.21873/anticanres.10984.

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Panjarian, Shoghag, and Jean-Pierre J. Issa. "The Roles of DNA Demethylases in Triple-Negative Breast Cancer." Pharmaceuticals 14, no. 7 (2021): 628. http://dx.doi.org/10.3390/ph14070628.

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Triple-negative breast cancers (TNBCs) are very heterogenous, molecularly diverse, and are characterized by a high propensity to relapse or metastasize. Clinically, TNBC remains a diagnosis of exclusion by the lack of hormone receptors (Estrogen Receptor (ER) and Progesterone Receptor (PR)) as well as the absence of overexpression and/or amplification of HER2. DNA methylation plays an important role in breast cancer carcinogenesis and TNBCs have a distinct DNA methylation profile characterized by marked hypomethylation and lower gains of methylations compared to all other subtypes. DNA methyla

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Srivastava, Amit, Haitham Idriss, Gobind Das, Sufian Abedrabbo, Mohd Sahir Shamsir та Dirar Homouz. "Deciphering the structural consequences of R83 and R152 methylation on DNA polymerase β using molecular modeling". PLOS ONE 20, № 3 (2025): e0318614. https://doi.org/10.1371/journal.pone.0318614.

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DNA polymerase β, a member of the X-family of DNA polymerases, undergoes complex regulations both in vitro and in vivo through various posttranslational modifications, including phosphorylation and methylation. The impact of these modifications varies depending on the specific amino acid undergoing alterations. In vitro, methylation of DNA polymerase β with the enzyme protein arginine methyltransferase 6 (PRMT6) at R83 and R152 enhances polymerase activity by improving DNA binding and processivity. Although these studies have shown that methylation improves DNA binding, the underlying mechanis

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Kim, Sook Ho, Hae Jun Jung, and Seok-Cheol Hong. "Z-DNA as a Tool for Nuclease-Free DNA Methyltransferase Assay." International Journal of Molecular Sciences 22, no. 21 (2021): 11990. http://dx.doi.org/10.3390/ijms222111990.

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Methylcytosines in mammalian genomes are the main epigenetic molecular codes that switch off the repertoire of genes in cell-type and cell-stage dependent manners. DNA methyltransferases (DMT) are dedicated to managing the status of cytosine methylation. DNA methylation is not only critical in normal development, but it is also implicated in cancers, degeneration, and senescence. Thus, the chemicals to control DMT have been suggested as anticancer drugs by reprogramming the gene expression profile in malignant cells. Here, we report a new optical technique to characterize the activity of DMT a

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von Kanel, Thomas, Dominik Gerber, André Schaller, et al. "Quantitative 1-Step DNA Methylation Analysis with Native Genomic DNA as Template." Clinical Chemistry 56, no. 7 (2010): 1098–106. http://dx.doi.org/10.1373/clinchem.2009.142828.

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Abstract Background: DNA methylation analysis currently requires complex multistep procedures based on bisulfite conversion of unmethylated cytosines or on methylation-sensitive endonucleases. To facilitate DNA methylation analysis, we have developed a quantitative 1-step assay for DNA methylation analysis. Methods: The assay is based on combining methylation-sensitive FastDigest® endonuclease digestion and quantitative real-time PCR (qPCR) in a single reaction. The first step consists of DNA digestion, followed by endonuclease inactivation and qPCR. The degree of DNA methylation is evaluated

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El Bouazzaoui, Layla, Jeroen M. Bugter, Emre Küçükköse, et al. "Abstract B003: BRAFV600E is essential for maintenance of the CpG island methylator phenotype and DNA methylation of PRC2 target genes in colon cancer." Cancer Research 85, no. 3_Supplement (2025): B003. https://doi.org/10.1158/1538-7445.dnamethylation-b003.

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Abstract In colon cancer, the BRAFV600E mutation is strongly associated with the CpG island methylator phenotype (CIMP). Here, we characterized the contribution of BRAFV600E to maintenance of aberrant DNA methylation. A reverse CRISPR gene editing approach was applied to revert the V600E mutation in BRAF back to wildtype (E600V) in organoids derived from a late-stage tumour. DNA methylation analyses identified 5187 differentially methylated CpGs within CpG islands, predominantly hypermethylated (82%) in BRAFV600E organoids, including genes associated with CIMP, as well as Polycomb Repressor Co

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Das, Partha M., and Rakesh Singal. "DNA Methylation and Cancer." Journal of Clinical Oncology 22, no. 22 (2004): 4632–42. http://dx.doi.org/10.1200/jco.2004.07.151.

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DNA methylation is an important regulator of gene transcription, and its role in carcinogenesis has been a topic of considerable interest in the last few years. Alterations in DNA methylation are common in a variety of tumors as well as in development. Of all epigenetic modifications, hypermethylation, which represses transcription of the promoter regions of tumor suppressor genes leading to gene silencing, has been most extensively studied. However, global hypomethylation has also been recognized as a cause of oncogenesis. New information concerning the mechanism of methylation and its contro

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Wong, Nicholas C., Zac Chatterton, Katrina Bell, et al. "DNA Methylation Profiling of Childhood Acute Lymphoblastic Leukaemia Using Illumina Infinium DNA Methylation27 Bead Arrays Identifies a Distinct DNA Methylation Signature Associated with Leukaemogenesis." Blood 116, no. 21 (2010): 4650. http://dx.doi.org/10.1182/blood.v116.21.4650.4650.

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Abstract Abstract 4650 Acute Lymphoblastic Leukaemia (ALL) is the most common form of cancer in children. Although up to 80% of cases can be characterised by either abnormal chromosome number (hyper- or hypo-diploidy) or a specific chromosome translocation, a significant proportion of cases do no exhibit any major chromosome abnormality. Indeed, no common gene mutation has been found to be associated with childhood leukaemia. This suggests that epigenetic modifications, in particular DNA methylation, may also play a significant role in ALL pathogenesis. Understanding the specific epigenetic ch

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Choi, Woo Lee, Young Geun Mok, and Jin Hoe Huh. "Application of 5-Methylcytosine DNA Glycosylase to the Quantitative Analysis of DNA Methylation." International Journal of Molecular Sciences 22, no. 3 (2021): 1072. http://dx.doi.org/10.3390/ijms22031072.

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In higher eukaryotes DNA methylation is a prominent epigenetic mark important for chromatin structure and gene expression. Thus, profiling DNA methylation is important for predicting gene expressions associated with specific traits or diseases. DNA methylation is achieved by DNA methyltransferases and can be actively removed by specific enzymes in a replication-independent manner. DEMETER (DME) is a bifunctional 5-methylcytosine (5mC) DNA glycosylase responsible for active DNA demethylation that excises 5mC from DNA and cleaves a sugar-phosphate bond generating a single strand break (SSB). In

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Zafon, Carles, Joan Gil, Beatriz Pérez-González, and Mireia Jordà. "DNA methylation in thyroid cancer." Endocrine-Related Cancer 26, no. 7 (2019): R415—R439. http://dx.doi.org/10.1530/erc-19-0093.

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In recent years, cancer genomics has provided new insights into genetic alterations and signaling pathways involved in thyroid cancer. However, the picture of the molecular landscape is not yet complete. DNA methylation, the most widely studied epigenetic mechanism, is altered in thyroid cancer. Recent technological advances have allowed the identification of novel differentially methylated regions, methylation signatures and potential biomarkers. However, despite recent progress in cataloging methylation alterations in thyroid cancer, many questions remain unanswered. The aim of this review i

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Meng, Huan X., James A. Hackett, Colm Nestor, et al. "Apoptosis and DNA Methylation." Cancers 3, no. 2 (2011): 1798–820. http://dx.doi.org/10.3390/cancers3021798.

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Kim, Jei, Jee-Yeon Kim, and Jean-Pierre J. Issa. "Aging and DNA Methylation." Current Chemical Biology 3, no. 1 (2009): 321–29. http://dx.doi.org/10.2174/187231309787158226.

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Kim, Jei, Jee-Yeon Kim, and Jean-Pierre Issa. "Aging and DNA Methylation." Current Chemical Biology 3, no. 1 (2009): 1–9. http://dx.doi.org/10.2174/2212796810903010001.

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Shu, Yachun. "Insight into DNA Methylation." Journal of Drug Delivery and Therapeutics 9, no. 2 (2019): 397–99. http://dx.doi.org/10.22270/jddt.v9i2.2419.

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Pokrywka, Małgorzata, Beata Kieć-Wilk, Anna Polus, and Iwona Wybrańska. "DNA methylation in obesity." Postępy Higieny i Medycyny Doświadczalnej 68 (November 27, 2014): 1383–91. http://dx.doi.org/10.5604/17322693.1130084.

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Hollander, Wouter, and Ingrid Meulenbelt. "DNA Methylation in Osteoarthritis." Current Genomics 16, no. 6 (2015): 419–26. http://dx.doi.org/10.2174/1389202916666150817212711.

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PINARBAŞI, Ergün. "DNA Methylation in Eukaryotes." Turkish Journal of Biology 21, no. 4 (1997): 515–23. http://dx.doi.org/10.55730/1300-0152.2497.

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Mahfouz, Magdy M. "RNA-directed DNA methylation." Plant Signaling & Behavior 5, no. 7 (2010): 806–16. http://dx.doi.org/10.4161/psb.5.7.11695.

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Michalowsky, L. A., and P. A. Jones. "DNA methylation and differentiation." Environmental Health Perspectives 80 (March 1989): 189–97. http://dx.doi.org/10.1289/ehp.8980189.

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Hitchins, Megan P., and Robyn L. Ward. "Favoritism in DNA Methylation." Cancer Prevention Research 2, no. 10 (2009): 847–49. http://dx.doi.org/10.1158/1940-6207.capr-09-0178.

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Shao, Dongxing, Cihang Liu, Yingying Wang, et al. "DNMT1 determines osteosarcoma cell resistance to apoptosis by associatively modulating DNA and mRNA cytosine‐5 methylation." FASEB Journal 37, no. 12 (2023). http://dx.doi.org/10.1096/fj.202301306r.

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AbstractCellular apoptosis is a central mechanism leveraged by chemotherapy to treat human cancers. 5‐Methylcytosine (m5C) modifications installed on both DNA and mRNA are documented to regulate apoptosis independently. However, the interplay or crosstalk between them in cellular apoptosis has not yet been explored. Here, we reported that promoter methylation by DNMT1 coordinated with mRNA methylation by NSun2 to regulate osteosarcoma cell apoptosis. DNMT1 was induced during osteosarcoma cell apoptosis triggered by chemotherapeutic drugs, whereas NSun2 expression was suppressed. DNMT1 was foun

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Rehman, Rao Saad, Mujahid Ali, Syed Ali Zafar, et al. "Regulatory Role of DNA Methylation and Its Significance in Plants." Asian Journal of Biochemistry, Genetics and Molecular Biology, July 1, 2022, 1–15. http://dx.doi.org/10.9734/ajbgmb/2022/v11i330267.

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DNA methylation is a well-known epigenetic modification that is essential for gene regulation and genome stability. Anomalies in plant development can result from aberrant DNA methylation patterns. DNA methylation is much more important in plants with more complicated genomes when it comes to growth and abiotic stress tolerance. Dynamic regulation via de novo methylation, maintenance of methylation, and active demethylation, which are catalysed by diverse enzymes that are targeted by different regulatory mechanisms, results in a unique DNA methylation state. We explain DNA methylation in plant

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May, B. "DNA methylation." Reactome - a curated knowledgebase of biological pathways 50 (September 30, 2014). http://dx.doi.org/10.3180/react_267652.1.

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