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Rozprawy doktorskie na temat „DNA Synthesis”

Autor: Grafiati

Data publikacji: 4 czerwca 2021

Data aktualizacji: 25 lipca 2025

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1

Lo, Allen Tak Yiu. "Protein dynamics on the lagging strand during DNA synthesis." Thesis, School of Chemistry, 2012. https://ro.uow.edu.au/theses/3684.

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DNA replication is one of the vital processes in the cell; it duplicates chromosomal DNA before a cell divides. In all organisms, DNA synthesis on the leading-strand template occurs continuously, whereas on the lagging strand a different mechanism is required. Due to the anti-parallel structure of double-stranded DNA, lagging-strand synthesis requires repeated RNA priming by a specialist primase and synthesis of short Okazaki fragments. How proteins carry out this dynamic process is still unknown. For Escherichia coli DNA replication, a lagging-strand three-point switch was proposed in 1999 to

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2

Lo, Pik Kwan Peggy. "Supramolecular DNA chemistry: assembly of DNA nanotubes and templated synthesis of DNA-mimetic polymers." Thesis, McGill University, 2010. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=95152.

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DNA has emerged as a promising template for the programmable assembly of structures on the nanometer scale. In particular, DNA nanotubes hold promise for a number of biological and materials applications, because of their high aspect ratio and encapsulation potential. Current construction methods result in symmetrical and cylindrical assemblies that are totally double-stranded, and are long and polydisperse. In order to investigate DNA nanotubes for applications as well-defined molecular hosts and one-dimensional templates, better control over their geometry, stiffness and porosity, ability to

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3

Araki, Kasumi. "Dual roles for DNA polymerase η in homologous DNA recombination and translesion DNA synthesis". Kyoto University, 2006. http://hdl.handle.net/2433/143860.

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4

Porssa, Manuchehr. "Synthesis of radiosensitisers targeted to DNA." Thesis, Brunel University, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.305165.

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5

Ellsmore, Victoria. "Human cytomegalovirus origin-dependent DNA synthesis." Thesis, University of Glasgow, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.340332.

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6

Devadoss, Babho. "Probing the Base Stacking Contributions During Translesion DNA Synthesis." Case Western Reserve University School of Graduate Studies / OhioLINK, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=case1222818842.

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7

Roberts, Lezah Wilette. "The synthesis of a tetracene quinone phosphoramidite photosensitizer to study charge migration through DNA." Thesis, Georgia Institute of Technology, 2001. http://hdl.handle.net/1853/30903.

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8

Erler, Christiane. "Synthesis of Metallic Nanowires Using Integrated DNA Molecules as Templates." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2010. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-27671.

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The DNA double helix is inherently a nanoscale wire-like object, possessing a 2 nm diameter as well as a remarkable capability for molecular recognition and the interaction with other chemical compounds, thus making it an attractive material for biologically driven assembly of artificial nanostructures. In this work methods for the construction of functional electronic networks from single DNA molecules are presented. For this, (i) the generation of patterns of distinct interconnects between micro-fabricated contact pads are explored by stretching end-specifically thiol-functionalized, single-

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9

Stockley, Martin Lee. "Design and synthesis of selective DNA-dependent protein kinase (DNA-PK) inhibitors." Thesis, University of Newcastle Upon Tyne, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.369816.

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10

Kapusuz, Derya. "Sol-gel Synthesis Of Dna Encapsulated Silica." Master's thesis, METU, 2009. http://etd.lib.metu.edu.tr/upload/2/12610627/index.pdf.

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Sol-gel processing routes for encapsulation of double stranded DNA in solid porous silica hosts have been established. The encapsulation was carried out in two steps: hydrolysis of a silica-forming alkoxide-based sol was followed by condensation/gelation to a solid form upon addition of a buffer solution containing DNA molecules. The effects of gelation chemistry and DNA amount on chemical and microstructural properties of resultant silica matrices and on DNA encapsulation efficiency were investigated. The analytical characterization was performed by UV-vis spectroscopy, 29Si nuclear magnetic

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11

Gilea, Manuela Aurora. "DNA and RNA synthesis in ionic liquids." Thesis, Queen's University Belfast, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.485198.

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The solid-phase synthesis of oligonucleotide derivatives such as phosphorothioates and phosphoroselenoates was investigated. Some ionic liquids containing the trlbexyl(tetradecyl)phosphonium cation and various anions proved to be very effective in dissolving the chalcogens (sulfur and , selenium) and to prepare oligonucleoside chalcogenophosphates. The suitability ofionic liquid-based chalcogen-transfer mixtures for the synthesis of oligonucleoside chalcogenophosphates on solid-phase was evaluated and subsequently the structure-activity relationship studied in detail. The compatibility of ioni

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12

Baccaro, Anna [Verfasser]. "Enzymatic Synthesis of Functionalized DNA / Anna Baccaro." Konstanz : Bibliothek der Universität Konstanz, 2010. http://d-nb.info/1029291632/34.

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13

Chow, Brian 1978. "Photoelectromechanical synthesis of low-cost DNA microarrays." Thesis, Massachusetts Institute of Technology, 2008. http://hdl.handle.net/1721.1/42405.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, School of Architecture and Planning, Program in Media Arts and Sciences, 2008.<br>Includes bibliographical references.<br>Recent advances in de novo gene synthesis, library construction, and genomic selection for target sequencing using DNA from custom microarrays have demonstrated that microarrays can effectively be used as the world's cheapest sources of complex oligonucleotide pools. Unfortunately, commercial custom microarrays are expensive and not easily accessible to academic researchers, and technical challenges still exist for dea

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14

Schilter, David. "Synthesis and DNA-binding of Metallocyclic Architectures." Thesis, The University of Sydney, 2009. http://hdl.handle.net/2123/5317.

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A new family of cationic N-heterocyclic ligand derivatives was prepared and characterised. Among these compounds are halide salts of the dications [Y(spacer)Y]2+, each of which comprise two N heterocyclic donor groups (Y = 4,4′-bipy, pyz, apyz, apym) linked by a conformationally flexible spacer such as (CH2)n, α,α′-xylylene, 2,6-lutidylene or thiabicyclo[3.3.1]nonane-2,6 diyl. The diquaternary halide salts were converted to NO3- and PF6- salts, and interaction of these bridging ligands with labile palladium(II) and platinum(II) precursors afforded several multinuclear complexes. Bis(4,4′-bipyr

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15

Schilter, David. "Synthesis and DNA-binding of Metallocyclic Architectures." University of Sydney, 2009. http://hdl.handle.net/2123/5317.

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PhD<br>A new family of cationic N-heterocyclic ligand derivatives was prepared and characterised. Among these compounds are halide salts of the dications [Y(spacer)Y]2+, each of which comprise two N heterocyclic donor groups (Y = 4,4′-bipy, pyz, apyz, apym) linked by a conformationally flexible spacer such as (CH2)n, α,α′-xylylene, 2,6-lutidylene or thiabicyclo[3.3.1]nonane-2,6 diyl. The diquaternary halide salts were converted to NO3- and PF6- salts, and interaction of these bridging ligands with labile palladium(II) and platinum(II) precursors afforded several multinuclear complexes. Bis(4,4

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16

Zheng, Qinguo. "Chemical synthesis of DNA containing modified bases by post-synthetic substitution and application of modified DNA to the study of protein-dna interaction." Thesis, University College London (University of London), 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.261892.

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17

Ghosh, Sumana. "Design And Synthesis Of Novel Interacalator Based Chemical Nuclease." Thesis, Indian Institute of Science, 2001. https://etd.iisc.ac.in/handle/2005/260.

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Deoxyribonucleic acid and ribonucleic acid under physiological condition are polyanions composed of heterocyclic bases linked through sugar phosphate backbone. Due to Watson-Crick base pairing, DNA exists in double-helical form between two antiparallel strands of nucleic acid. Different conformations of DNA is possible among which the B-DNA form is considered to be the most common, and it is a right-handed double-helix with base pairs stacked at the center. There are two well-defined grooves termed as major and minor grooves, each has characteristic width and depth. Most of the DNA binding pro

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18

Ghosh, Sumana. "Design And Synthesis Of Novel Interacalator Based Chemical Nuclease." Thesis, Indian Institute of Science, 2001. http://hdl.handle.net/2005/260.

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Deoxyribonucleic acid and ribonucleic acid under physiological condition are polyanions composed of heterocyclic bases linked through sugar phosphate backbone. Due to Watson-Crick base pairing, DNA exists in double-helical form between two antiparallel strands of nucleic acid. Different conformations of DNA is possible among which the B-DNA form is considered to be the most common, and it is a right-handed double-helix with base pairs stacked at the center. There are two well-defined grooves termed as major and minor grooves, each has characteristic width and depth. Most of the DNA binding pro

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19

Loh, Ern. "Dissecting genetic and structural determinants of accurate DNA synthesis by DNA polymerase I /." Thesis, Connect to this title online; UW restricted, 2006. http://hdl.handle.net/1773/5007.

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20

Yakisich, Juan Sebastián. "Regulation of ongoing DNA synthesis in normal and neoplastic brain tissue /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-433-3/.

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21

Rowan, Andrea Leah Margaret. "hDREF, a MEF2 sensitive regulator of DNA synthesis." Thesis, University of Ottawa (Canada), 2003. http://hdl.handle.net/10393/26393.

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The Myocyte Enhancing Factor 2 (MEF2) family of proteins have been implicated in a wide variety of cellular mechanisms including: muscle and neuronal differentiation, inhibition of apoptosis, upregulation of c jun expression, and embryonic and post-natal cardiac development. In the course of my research I have identified a novel MEF2-responsive gene referred to as h&barbelow;uman D&barbelow;NA R&barbelow;eplication Related E&barbelow;lement F&barbelow;actor (hDREF). Three putative MEF2 consensus-binding sites have been found within the two untranslated regions (UTRs) of the hDREF sequence (whi

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22

Burlinson, B. "Unscheduled DNA synthesis as an indicator of genotoxicity." Thesis, Swansea University, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.636182.

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The escalating production of new chemical entities and the rising cost of long term toxicity studies has necessitated the development of a number of short-term terms. This thesis details the development and initial validation of assays in which the end point investigated was the measurement of DNA excision repair i.e. unscheduled DNA synthesis (UDS). Initially the assay was developed in primary rat hepatocytes and later progressed so that the exposure to the test material took place <I>in vivo</I> with subsequent radiolabelling of the repair sites taking place <I>in vitro. </I>In both cases th

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23

Sadowski, John Paul. "Design and synthesis of dynamically assembling DNA nanostructures." Thesis, Harvard University, 2013. http://dissertations.umi.com/gsas.harvard:11272.

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Kinetically controlled isothermal growth is fundamental to biological development, but it remains challenging to rationally design molecular systems that self-assemble isothermally into complex geometries via prescribed assembly and disassembly pathways. By exploiting the programmable chemistry of base pairing, sophisticated spatial and temporal control have both been demonstrated in DNA self-assembly, but largely as separate pursuits. This dissertation extends a new approach, called developmental self-assembly, that integrates temporal with spatial control by using a prescriptive molecular pr

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24

Clark, D. R. "Some aspects of DNA synthesis in Anabaena 2C." Thesis, University of Liverpool, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.383453.

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25

Dexter, Hannah R. "Synthesis and properties of DNA containing O6-pterosinBguanine." Thesis, University of Sheffield, 2016. http://etheses.whiterose.ac.uk/14418/.

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26

Emig, Christopher Joseph. "Photoelectrochemical array platform for genomic scale DNA synthesis." Thesis, Massachusetts Institute of Technology, 2006. http://hdl.handle.net/1721.1/37200.

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Thesis (M. Eng.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 2006.<br>Includes bibliographical references (leaves 56-58).<br>Molecular and synthetic biologists have increasing demand for large, high-fidelity constructs of synthetic DNA. Recent developments in harvesting oligonucleotides from DNA microarrays has proven that these can be assembled into large constructs of DNA for costs significantly less than traditional methods. This thesis presents a complete platform for the photoelectrochemical cleavage of protecting groups during in situ DNA

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27

Rospigliosi, Alessandro. "Improving the conduction of DNA by molecular synthesis." Thesis, University of Cambridge, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.613839.

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28

Wilks, Thomas R. "Synthesis of DNA-polymer conjugates using RAFT polymerisation." Thesis, University of Warwick, 2013. http://wrap.warwick.ac.uk/58568/.

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The use of reversible addition–fragmentation chain transfer (RAFT) polymerisation for the production of DNA–polymer conjugates is explored. Chapter 1 gives a general introduction to the field of DNA–polymer conjugates, their potential applications and methods for their synthesis. The need for a general, solutionphase technique for DNA–polymer conjugation is highlighted. In Chapters 2-5, the use of a number of different strategies for the production of DNA–polymer conjugates is described. Amide coupling (Chapter 2) is found to produce the desired products only under very specific reaction condi

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29

Whitfield, Colette J. "Enzymatic protocols for the synthesis of designer DNA." Thesis, University of Newcastle upon Tyne, 2016. http://hdl.handle.net/10443/3528.

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The enzymatic synthesis of long DNA with a controllable sequence, length and functional content has been reported. This method, involves the heating and cooling of the reaction components, resulting in the extension of repeating units. The key components comprise of the oligo seed of interest, the deoxynucleotide triphosphates (dNTPs), and a DNA polymerase. Using a thermostable Thermococcus gorgonarius Family B DNA polymerase exonuclease minus variant, Z3, and 20 heat-cool cycles, long DNA up to 20,000 base pairs bearing repeating units between 1 to 40 bases was produced. Incorporation of arti

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30

Paniwnyk, Zennia. "Synthesis, DNA interactions and cytotoxicity of novel chloroethylaminoanthraquinones." Thesis, De Montfort University, 2000. http://hdl.handle.net/2086/13278.

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The design of DNA directed nitrogen mustards has led to the development of compounds with increased specificity for DNA and enhanced cytotoxicity compared to similar untargeted mustards. By linking an intercalating anthraquinone chromophore to a nitrogen mustard function it was anticipated that such compounds would also have the potential to irreversibly inhibit the topoisomerase II (topo II) enzyme.

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31

Mayer, Alain. "Synthesis and triplex forming properties of pyrrolidino-DNA /." [S.l.] : [s.n.], 2005. http://www.zb.unibe.ch/download/eldiss/05mayer_a.pdf.

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32

Carneiro, Karina. "DNA - macromolecule conjugates: synthesis and hierarchical self-assembly." Thesis, McGill University, 2013. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=119476.

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The remarkable molecular recognition specificity of DNA, combined with its structural and biological properties, makes it useful as a programmable and addressable building block for materials science. The materials constructed from nucleic acids have expanded the role of DNA and RNA beyond biology, into a useful component of advanced synthetic materials. The study of DNA self-assembly is rapidly evolving and will most likely find new and unforeseen applications ranging from medicine and biology to nanoelectronics and nano-optics. The error-free and predictable self-assembly of DNA over many

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33

Chan, Kara Y. "MECHANISMS OF TRINUCLEOTIDE REPEAT INSTABILITY DURING DNA SYNTHESIS." UKnowledge, 2019. https://uknowledge.uky.edu/toxicology_etds/29.

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Genomic instability, in the form of gene mutations, insertions/deletions, and gene amplifications, is one of the hallmarks in many types of cancers and other inheritable genetic disorders. Trinucleotide repeat (TNR) disorders, such as Huntington’s disease (HD) and Myotonic dystrophy (DM) can be inherited and repeats may be extended through subsequent generations. However, it is not clear how the CAG repeats expand through generations in HD. Two possible repeat expansion mechanisms include: 1) polymerase mediated repeat extension; 2) persistent TNR hairpin structure formation persisting in the

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34

Brucale, Marco <1976&gt. "Design, synthesis and characterization of DNA supramolecular nanostructures." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2007. http://amsdottorato.unibo.it/474/1/Brucale_PhDthesis_2007.pdf.

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35

Brucale, Marco <1976&gt. "Design, synthesis and characterization of DNA supramolecular nanostructures." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2007. http://amsdottorato.unibo.it/474/.

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36

Ivanova, Tsvetomira Georgieva 1978. "The DNA damage and the DNA synthesis checkpoints converge at the MBF transcription factor." Doctoral thesis, Universitat Pompeu Fabra, 2012. http://hdl.handle.net/10803/116932.

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DNA damage is an ongoing threat to both the ability of the cell to faithfully transmit genetic information to its offspring as well as to its own survival. In order to maintain genomic integrity, eukaryotes have developed a highly conserved mechanism to detect, signal and repair damage in DNA, known as the DNA damage response (DDR). In fission yeast the two DDR pathways converge at the regulation of single transcriptional factor complex (MBF) resulting in opposite directions. We have shown that when the DNA-synthesis checkpoint is activated, Max1 is phosphorylated by Cds1 resulting in the abro

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37

Li, Kaiyu. "Supramolecular Ruthenium(II) and Osmium(II) Complexes: Synthesis, Characterization, DNA Binding and DNA Photocleavage." University of Dayton / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=dayton1513235232385279.

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38

Yu, Hongchuan. "Novel Cyclo Deoxynucleoside: Synthesis and Evaluation." Thesis, Boston College, 2012. http://hdl.handle.net/2345/2751.

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Thesis advisor: Larry W. McLaughlin<br>Thesis advisor: Mary F. Roberts<br>Nucleic acids are essential biological molecules for life. For example, deoxyribonucleic acid (DNA) is the main genetic information carrier; ribonucleic acid (RNA) plays a critical role in translation and transcription. These characteristics place nucleic acids as the fundamental genetic materials of a living system. Since over a century ago, intensive attempts have been made by researchers to study the nucleic acid properties. For chemists, it is particularly interesting and important to understand the relationship betw

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39

Muscat, Richard A. "Molecular motion and templated chemistry coordinated by DNA nanomachines." Thesis, University of Oxford, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.572658.

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This thesis investigates ways in which a nanoscale production line may be built from synthetic DNA components. One property of a production line is motion, the coordinated movement of components, in this case strands of DNA, between specific locations. Another property is the ability to assemble a product, where smaller molecular building blocks are attached to D A and react when brought together by the DNA assembly line. An important fea- ture of either task is the ability of the mechanism to proceed with minimum user interaction: it is preferable that the assembly line be autonomous. The cha

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40

Onyemauwa, Frank Okezie. "Investigation of the Role of Groove Hydration and Charged Nucleosides in DNA Charge Transfer." Diss., Georgia Institute of Technology, 2006. http://hdl.handle.net/1853/11634.

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Structural analyses of DNA oligonucleotides indicate the presence of bound water molecules in the major and minor grooves of DNA. These water molecules participate in DNA charge transfer by their reaction with guanosine radical cation to form 7,8-dihydro-8-oxo-guanine (8-oxoG), which when treated with a base leads to DNA strand cleavage. We probed the reaction of guanosine radical cation with water with series of alkyl substituted cytidines and thymidines by incorporating the modified nucleosides into anthraquinone linked DNA duplexes and irradiating them with UV light at 350 nm. The incorpora

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41

Holzberger, Bastian [Verfasser]. "From Multi-fluorinated DNA Polymerases to Insights into DNA Synthesis by NMR spectroscopy / Bastian Holzberger." Konstanz : Bibliothek der Universität Konstanz, 2012. http://d-nb.info/1026847125/34.

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Tetzlaff, Charles N. "Synthesis and evaluation of acylated DNA and RNA oligomers /." Thesis, Connect to Dissertations & Theses @ Tufts University, 2001.

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Thesis (Ph.D.)--Tufts University, 2001.<br>Adviser: Clemens Richert. Submitted to the Dept. of Chemistry. Includes bibliographical references (leaves 228-235). Access restricted to members of the Tufts University community. Also available via the World Wide Web;

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43

Rahman, Khondaker Mirazur. "Design, synthesis and Evaluation of DNA interactive small molecules." Thesis, University College London (University of London), 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.509314.

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Giles, Yvonne. "Synthesis, DNA interactions and activation of novel cytotoxic anthraquinones." Thesis, De Montfort University, 1999. http://hdl.handle.net/2086/10751.

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Mitoxantrone is a dihydroxyanthracenedione derivative with significant clinical activity against advanced breast cancer, lymphoma and several types of leukaemia. However, as with all conventional anticancer agents, its non-specific nature results in dose-limiting systemic toxicity. The pharmacological (and toxicological) effects of mitoxantrone are thought to be mediated through its interaction with DNA and the DNA processing enzyme, topoisomerase II. Hence, an investigation of the DNA binding properties of mitoxantrone and related bis-substituted alkylaminoanthraquinones was undertaken with a

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45

McDonnell, Ursula J. "Synthesis and DNA Binding of Novel Ruthenium Polypyridyl Complexes." Thesis, University of Warwick, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.526217.

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46

Johnson, Heather Aileen. "Synthesis and evaluation of iminosugars as DNA binding agents." Thesis, University of Nottingham, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.342492.

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47

Isaac, Christian James. "Redox active metal complexes : synthesis and DNA binding studies." Thesis, University of Newcastle Upon Tyne, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.287813.

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48

Turlington, Ralph Donald III. "Mitigating security issues in the evolving DNA synthesis industry." Thesis, Massachusetts Institute of Technology, 2013. http://hdl.handle.net/1721.1/80897.

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Thesis (S.M. in Technology and Policy)--Massachusetts Institute of Technology, Engineering Systems Division, 2013.<br>This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.<br>Cataloged from student-submitted PDF version of thesis.<br>Includes bibliographical references (p. 102-108).<br>DNA synthesis technologies are advancing at exponential rates, with production of ever longer, more complex, and less expensive sequences of double stranded DNA. This has fostered development of industrial scale design,

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49

Durand, Adeline. "Synthesis of oligonucleotide analogues for use in DNA nanostructures." Thesis, University of Southampton, 2010. https://eprints.soton.ac.uk/173975/.

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Thanks to its ability to form duplexes through selective base-pair recognition, DNA is a unique material for orderly self-assembled construction at the nanoscale. To develop a nanotechnology platform on a grid of addressable molecular building blocks using DNA node structures, DNA complexes need to be fixed onto surfaces. To fulfil this requirement on lipid membranes, phosphoramidites monomers modified with a cholesterol moiety and a spacer unit were synthesised. The hydrophobic spacer provides separation between the hydrophobic cholesterol moiety and the phosphate backbone of the DNA strand.

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50

De, Haan Judy Bettina. "DNA synthesis and methylation in normal and transformed cells." Master's thesis, University of Cape Town, 1985. http://hdl.handle.net/11427/27266.

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In this study, DNA methylation was examined during the eukaryotic cell cycle, and shown to occur throughout the S phase as well as during the "early" G₂ phase. However, DNA synthesis and methylation of newly synthesized DNA did not occur simultaneously, but the latter lagged behind DNA synthesis by about two hours. Once added during the S phase, the methyl groups were stably maintained in the DNA. Various compounds which are known to affect DNA synthesis in tissue cultured cells, were tested for their ability to alter the methylation status of DNA. The effects of three DNA synthesis inhibitors

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