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Artykuły w czasopismach na temat „DOPA”

Autor: Grafiati

Data publikacji: 4 czerwca 2021

Data aktualizacji: 25 lipca 2025

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1

Eldrup, Ebbe, and Erik A. Richter. "DOPA, dopamine, and DOPAC concentrations in the rat gastrointestinal tract decrease during fasting." American Journal of Physiology-Endocrinology and Metabolism 279, no. 4 (2000): E815—E822. http://dx.doi.org/10.1152/ajpendo.2000.279.4.e815.

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The aim of the present study was to test the hypothesis that 3,4-dihydroxyphenylalanine (DOPA) and dopamine (DA) in the gastrointestinal tract are to a large extent of exogenous origin and derived from food. Tissue concentrations of norepinephrine (NE), epinephrine (Epi), DA, DOPA, and 3,4-dihydroxyphenylacetic acid (DOPAC), as measured by reverse-phase HPLC with electrochemical detection, were studied in fed and 4-day-fasted Wistar rats as well as in sympathectomized and adrenodemedullated rats. Sympathectomy and adrenal demedullectomy decreased tissue concentrations of NE and Epi, respective

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2

Eldrup, Ebbe, Svend Erik Møller, JAN Andreasen, and Niels Juel Christensen. "Effects of Ordinary Meals on Plasma Concentrations of 3,4-Dihydroxyphenylalanine, Dopamine Sulphate and 3,4-Dihydroxyphenylacetic Acid." Clinical Science 92, no. 4 (1997): 423–30. http://dx.doi.org/10.1042/cs0920423.

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1. Plasma concentrations of 3,4-dihydroxyphenylalanine (DOPA), dopamine sulphate (DA-S), and 3,4-dihydroxyphenylacetic acid (DOPAC) in humans have been claimed to be indexes of sympathetic nervous activity, but the source and significance of plasma DOPA, DOPAC and DA-S have not been completely elucidated. 2. The effects of ordinary meals on plasma concentrations of total dopamine, mainly DA-S, DOPAC and DOPA were studied in seven healthy subjects. Venous blood was collected every hour for 25 h, while subjects were either fasting or received three meals at 9.00 hours, 13.00 hours and 18.00 hour

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3

Okada, Maki, Ryuji Nakao, Rie Hosoi та ін. "Microdialysis with Radiometric Monitoring of L-[β-11C]DOPA to Assess Dopaminergic Metabolism: Effect of Inhibitors of L-Amino Acid Decarboxylase, Monoamine Oxidase, and Catechol-O-Methyltransferase on Rat Striatal Dialysate". Journal of Cerebral Blood Flow & Metabolism 31, № 1 (2010): 124–31. http://dx.doi.org/10.1038/jcbfm.2010.58.

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The catecholamine, dopamine (DA), is synthesized from 3,4-dihydroxy-L-phenylalanine (L-DOPA) by aromatic L-amino acid decarboxylase (AADC). Dopamine metabolism is regulated by monoamine oxidase (MAO) and catechol- O-methyltransferase (COMT). To measure dopaminergic metabolism, we used microdialysis with radiometric detection to monitor L-[β-11C]DOPA metabolites in the extracellular space of the rat striatum. We also evaluated the effects of AADC, MAO, and COMT inhibitors on metabolite profiles. The major early species measured after administration of L-[β-11C]DOPA were [11C]3,4-dihydroxyphenyl

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4

Soares-da-Silva, P., M. Pestana, and M. H. Fernandes. "Involvement of tubular sodium in the formation of dopamine in the human renal cortex." Journal of the American Society of Nephrology 3, no. 9 (1993): 1591–99. http://dx.doi.org/10.1681/asn.v391591.

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This study has examined the influence of sodium (0, 20, 40, 80, 120, and 160 mM) and ouabain (100, 500, and 1,000 microM), an inhibitor of the enzyme Na(+)-K+ ATPase, on the synthesis of dopamine in slices of human renal cortex loaded with exogenous L-dihydroxyphenylalanine (L-DOPA). The deamination of newly formed dopamine into 3,4-dihydroxyphenylacetic acid (DOPAC) was also examined. The formation of dopamine and its deamination to DOPAC in slices and homogenates of human renal cortex closely depended on the concentration of L-DOPA added to the medium; in homogenates of renal cortex, the pro

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5

Buu, N. T., and C. Lussier. "Origin of dopamine in the rat adrenal cortex." American Journal of Physiology-Renal Physiology 258, no. 2 (1990): F287—F291. http://dx.doi.org/10.1152/ajprenal.1990.258.2.f287.

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The hypothesis that dopamine (DA) is involved in the control of aldosterone secretion is given some support by the finding of DA in the adrenal cortex of several species, but the source of this DA is not known. This study showed that the administration of L-dopa to intact rats or medullectomized rats caused a significant DA increase in the adrenal cortex. The DA increase in the cortex was more pronounced than in the medulla, coincident with higher L-dopa uptake by the cortical tissue. Tyrosine administration raised DA levels only in the medulla. Sympathectomy of the rat by 6-hydroxydopamine tr

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6

Armando, I., S. Nowicki, J. Aguirre, and M. Barontini. "A decreased tubular uptake of dopa results in defective renal dopamine production in aged rats." American Journal of Physiology-Renal Physiology 268, no. 6 (1995): F1087—F1092. http://dx.doi.org/10.1152/ajprenal.1995.268.6.f1087.

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A major proportion of urinary dopamine derives from the renal decarboxylation of circulating dopa. This study evaluates the effects of aging on renal production of dopamine using 3- and 12-mo-old male Wistar rats. Urinary excretion of Na+, norepinephrine (NE), 3,4-dihydroxyphenylglycol, and dopa were similar in the two groups. Urinary dopamine and 3,4-dihydroxyphenylacetic acid (DOPAC) were lower in older animals (dopamine, 20 +/- 6 vs. 47 +/- 7 nmol/24 h, P < 0.001; DOPAC, 142 +/- 36 vs. 304 +/- 56 nmol/24 h, P < 0.03). Urinary 3-O-methyldopa (OM-dopa) was higher in 12-mo-old rats (6.2

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7

Lavoie, Mark P., Meg Palmatier, Frank T. Gentile, et al. "Two PC 12 Pheochromocytoma Lines Sealed in Hollow Fiber-Based Capsules Tonically Release L-Dopa In Vitro." Cell Transplantation 2, no. 2 (1993): 163–73. http://dx.doi.org/10.1177/096368979300200209.

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Two PC12 cell-derived lines have been studied following encapsulation into polymer-based hollow fibers with respect to secreted catecholamines and their metabolites. Cellular encapsulation provides a chronic microperfusion environment within which basally secreted PC12 products can be readily measured. Encapsulated PC12 cells grown and held under the conditions specified in this report basally release amounts exceeding their total cellular stores of the dopamine precursor L-DOPA and the electrochemically active dopamine metabolites DOPAC and HVA during 45-min static incubations. Under these sa

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8

Dutton, J., L. G. Copeland, J. R. Playfer, and N. B. Roberts. "Measuring L-dopa in plasma and urine to monitor therapy of elderly patients with Parkinson disease treated with L-dopa and a dopa decarboxylase inhibitor." Clinical Chemistry 39, no. 4 (1993): 629–34. http://dx.doi.org/10.1093/clinchem/39.4.629.

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Abstract We have established a method for measuring L-dopa in plasma and urine, including the metabolites dopamine and L-dopac, using separation by ion-pair reversed-phase HPLC and quantification with an electrochemical detector. The assay was applied to the therapeutic monitoring of elderly patients with established Parkinson disease being treated with L-dopa plus a dopa decarboxylase inhibitor. Plasma L-dopa was evaluated in relation to dosage and postdose sampling time in 71 outpatients with Parkinson disease. L-Dopa concentrations were greatest in the patients taking the highest dosages pr

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9

Eisenhofer, G., D. S. Goldstein, R. Stull, et al. "Simultaneous liquid-chromatographic determination of 3,4-dihydroxyphenylglycol, catecholamines, and 3,4-dihydroxyphenylalanine in plasma, and their responses to inhibition of monoamine oxidase." Clinical Chemistry 32, no. 11 (1986): 2030–33. http://dx.doi.org/10.1093/clinchem/32.11.2030.

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Abstract This is a reversed-phase liquid-chromatographic method, with electrochemical detection, for simultaneously measuring, in plasma, the concentrations of the catecholamine precursor dihydroxyphenylalanine (DOPA); the endogenous catecholamines norepinephrine, epinephrine, and dopamine; and the deaminated catecholamine metabolites dihydroxyphenylacetic acid (DOPAC) and dihydroxyphenylglycol (DHPG). We used this method to assess effects of monoamine oxidase (EC 1.4.3.4) inhibition in humans. Plasma DHPG concentrations as determined by the present method (mean 826, SEM 61 ng/L) were similar

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10

Lorenc-Koci, Elżbieta, Kinga Kamińska, Tomasz Lenda, and Jolanta Konieczny. "The Effect of Chronic Treatment with the Inhibitor of Phosphodiesterase 5 (PDE5), Sildenafil, in Combination with L-DOPA on Asymmetric Behavior and Monoamine Catabolism in the Striatum and Substantia Nigra of Unilaterally 6-OHDA-Lesioned Rats." Molecules 29, no. 18 (2024): 4318. http://dx.doi.org/10.3390/molecules29184318.

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The use of phosphodiesterase inhibitors in the treatment of Parkinson’s disease is currently widely discussed. The study aimed to investigate the impact of acute and chronic treatment with the phosphodiesterase 5 inhibitor, sildenafil, at low and moderate doses of 2 mg/kg and 6 mg/kg, and L-DOPA (12.5 mg/kg), alone or in combination, on asymmetric behavior and dopamine (DA) and serotonin metabolism in the striatum and substantia nigra of unilaterally 6-OHDA-lesioned rats. Acute administration of sildenafil at both tested doses jointly with L-DOPA significantly increased the number of contralat

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11

Ash, Caroline. "The dope on L-dopa metabolism." Science 364, no. 6445 (2019): 1043.11–1045. http://dx.doi.org/10.1126/science.364.6445.1043-k.

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12

Xu, Suxia, Qingyun Huang, Chunsong Lin, et al. "Transcriptome comparison reveals candidate genes responsible for the betalain-/anthocyanidin-production in bougainvilleas." Functional Plant Biology 43, no. 3 (2016): 278. http://dx.doi.org/10.1071/fp15246.

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The occurrence of betalains and anthocyanins is mutually exclusive, which is a curious phenomenon in the plant kingdom, and the biochemical mechanisms for this restriction are unknown. In the present study, we performed transcriptome analysis of two betalain-producing species, red Bougainvillea glabra Choisy. ‘Sanderiana’ (R) and white B. glabra ‘Alba’ (W) by transcriptome sequencing. In total, we obtained 69 692 (Red) and 60 727 (White) genes with an average length of 665 and 728 bp respectively. Out of 3106 significantly differentially-expressed genes (71%), 1003 were R-specific (32%), and 1

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13

Ibarra, F. R., J. Aguirre, S. Nowicki, M. Barontini, E. E. Arrizurieta, and I. Armando. "Demethylation of 3-O-methyldopa in the kidney: a possible source for dopamine in urine." American Journal of Physiology-Renal Physiology 270, no. 5 (1996): F862—F868. http://dx.doi.org/10.1152/ajprenal.1996.270.5.f862.

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The possibility that demethylation of 3-O-methyldopa (OM-dopa) in the kidney could provide a source for dopamine in the urine was explored in male Wistar rats aged 60-90 days, using in vivo and in vitro approaches. The results showed that endogenous OM-dopa is filtered, reabsorbed and extensively metabolized in the kidney. Infusion of OM-dopa into anesthetized rats increased significantly urinary excretion of Na+, dopa, dopamine, and 3,4 dihydroxyphenylacetic acid. Whole kidney homogenates, slices from renal cortex, and microdissected proximal tubules produced significant amounts of both dopa

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14

Zalyalova, Z. A., D. M. Khasanova, and M. V. Ugrumov. "Plasma catecholamine levels in the early stages of treatment-naïve Parkinson’s disease." Almanac of Clinical Medicine 46, no. 8 (2018): 792–801. http://dx.doi.org/10.18786/2072-0505-2018-46-8-792-801.

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Rationale: Parkinson's disease (PD) is a neurodegenerative disorder with predominant involvement of catecholamine-producing neurons of the central and peripheral nervous system. Taking into account the relative availability and low costs of plasma catecholamine measurements, it is worthwhile to study these parameters as biomarkers of the early stages of PD.Aim: To determinate whether plasma levels of dopamine (DA), norepinephrine (NE), L-3,4-dihydroxyphenylalanine (DOPA) and dihydroxyphenylacetic acid (DOPAC) in patients with early stages of PD are related with akinetic-rigid and tremor-domina

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15

Grossman, Ehud, Aaron Hoffman, Ines Armando, Zaid Abassi, Irwin J. Kopin, and David S. Goldstein. "Sympathoadrenal contribution to plasma dopa (3,4-dihydroxyphenylalanine) in rats." Clinical Science 83, no. 1 (1992): 65–74. http://dx.doi.org/10.1042/cs0830065.

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1. To determine the sources of dopa (3,4-dihydroxyphenylalanine) in plasma, we measured regional arteriovenous differences, tissue concentrations and urinary excretion of dopa during systemic intravenous infusions of I-[3H]dopa into anaesthetized intact rats and rats pretreated with the sympathetic neurotoxin, 6-hydroxydopamine. 2. In intact rats, large arteriovenous increments in plasma dopa concentrations were noted in the femoral (47%) and adrenal (141%) beds, with a small arterial-portal venous increment (11%), whereas in the kidney there was a substantial (47%) arteriovenous decrement in

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16

Cao, Wenhui, Shaodong Liang, Yindong Yang, Chuanzhen Zhu, Li Sun, and Liming Zhang. "Fisetin Ameliorates Levodopa-Induced Dyskinesia in Experimental Model Parkinson's Disease: Role of Mitochondrial Activities and Monoamines Turnover." Natural Product Communications 17, no. 11 (2022): 1934578X2211366. http://dx.doi.org/10.1177/1934578x221136674.

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Background: Levodopa (or l-DOPA) is the current standard of care for the management of Parkinson's disease (PD), but its chronic administration has been associated with the development of LID (l-DOPA-induced dyskinesia). Fisetin is a dietary flavonoid known for its neuroprotective efficacy. Aim: To determine the neuroprotective potential of fisetin in 6-hydroxydopamine (6-OHDA)-lesioned LID animals. Methods: 6-OHDA (12 µg and L-ascorbic acid [10 µL]) was injected in a substantial nigra of Sprague-Dawley rat to develop PD followed by l-DOPA (20 mg/kg and benserazide HCl [5 mg/kg], 42 days) to i

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17

Kura, Aminu Umar, Samer Hasan Hussein-Al-Ali, Mohd Zobir Hussein, and Sharida Fakurazi. "Preparation of Tween 80-Zn/Al-Levodopa-Layered Double Hydroxides Nanocomposite for Drug Delivery System." Scientific World Journal 2014 (2014): 1–10. http://dx.doi.org/10.1155/2014/104246.

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We incorporated anti-Parkinsonian drug, levodopa (dopa), in Zn/Al-LDH by coprecipitation method to form dopa-LDH nanocomposite. Further coating of Tween-80 on the external surfaces of dopa-LDH nanocomposite was achieved through the oxygen of C=O group of Tween-80 with the layer of dopa-LDH nanocomposite. The final product is called Tween-dopa-LDH nanocomposite. The X-ray diffraction indicates that the Tween-dopa-LDH nanocomposite was formed by aggregation structure. From the TGA data, the Tween-80 loading on the surface of LDH and dopa-LDH was 8.6 and 7.4%, respectively. The effect of coating

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18

Carstam, R., C. Hansson, H. Rorsman, and E. Rosengren. "Oxidation of dopa in the skin of black and albino mice." Acta Dermato-Venereologica 66, no. 5 (1986): 369–74. http://dx.doi.org/10.2340/0001555566369374.

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The dopa oxidase activity of tyrosinase in the skin from albino and black mice was assayed using a technique based on the formation of two diastereomers of 5-S-cysteinyldopa when incubating tissue extracts with both L-dopa and D-dopa as substrates in the presence of cysteine. The amounts of 5-S-L-cysteinyl-L-dopa and 5-S-L-cysteinyl-D-dopa formed were then determined. In the extract from black mouse skin the L-L-diastereomer was produced in more than ten times the amount of the L-D-diastereomer. This stereospecific dopa-oxidation is indicative of the presence of tyrosinase and corresponds well

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19

Taira, Shu, Akari Ikeda, Yuki Sugiura, et al. "Pyrylium based derivatization imaging mass spectrometer revealed the localization of L-DOPA." PLOS ONE 17, no. 8 (2022): e0271697. http://dx.doi.org/10.1371/journal.pone.0271697.

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Simultaneous imaging of l-dihydroxyphenylalanine (l-DOPA), dopamine (DA) and norepinephrine (NE) in the catecholamine metabolic pathway is particularly useful because l-DOPA is a neurophysiologically important metabolic intermediate. In this study, we found that 2,4,6-trimethylpyrillium tetrafluoroborate (TMPy) can selectively and efficiently react with target catecholamine molecules. Specifically, simultaneous visualization of DA and NE as metabolites of l-DOPA with high steric hinderance was achieved by derivatized-imaging mass spectrometry (IMS). Interestingly, l-DOPA showed strong localiza

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20

Alemayehu, Biniyam, Abenet Tafesse, and Yared Zenebe. "Early onset peak-dose L-dopa induced dyskinesia in 55-year-old Ethiopian Parkinson’s disease patient." Ethiopian Pharmaceutical Journal 34, no. 1 (2019): 73–74. http://dx.doi.org/10.4314/epj.v34i1.7.

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A case study of a 55-year-old newly diagnosed Parkinson’s disease patient naïve to L-dopa, who develop disabling early onset L-dopa induced dyskinesia (LID), which occurs immediately following L-dopa administration is presented. It is recommend to start with low dose L-dopa and to escalate slowly to avoid L-dopa included dyskinesia in dopamine naïve Parkinson’s disease patients.Keywords: Parkinson’s disease, L-dopa, peak-dose induced dyskinesia, 55-year-old male, Ethiopian

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21

Falck, B., L. Andersson, A. Mikulowska, and G. Ronquist. "alpha/Amino/n/butyric acid methyl ester induces concentrative uptake of L/dopa in human Langerhans' cells normally not operative for L/dopa transport." Acta Dermato-Venereologica 73, no. 3 (1993): 197–99. http://dx.doi.org/10.2340/0001555573197199.

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We recently reported the existence of two kinds of human epidermal Langerhans' cells (LC), one which can take up and accumulate L/dopa and one which cannot. The dopa(+) LC take up L/dopa by carrier/mediated exchange diffusion, that is, the influx of L/dopa and the outflow of an intracellular substance are linked via the same carrier. The nature of the fundamental difference between L/dopa(+) and L/dopa(/) cells has not been clarified. We have now found that alpha/amino/n/butyric acid methyl ester (ABA/OME) penetrates into intracellular compartments, perhaps endosomes or lysosomes, of all LC, w

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22

MORIN, Bénédicte, J. Michael DAVIES, and T. Roger DEAN. "The protein oxidation product 3,4-dihydroxyphenylalanine (DOPA) mediates oxidative DNA damage." Biochemical Journal 330, no. 3 (1998): 1059–67. http://dx.doi.org/10.1042/bj3301059.

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A major product of hydroxy-radical addition to tyrosine is 3,4-dihydroxyphenylalanine (DOPA) which has reducing properties. Protein-bound DOPA (PB-DOPA) has been shown to be a major component of the stable reducing species formed during protein oxidation under several conditions. The aim of the present work was to investigate whether DOPA, and especially PB-DOPA, can mediate oxidative damage to DNA. We chose to generate PB-DOPA using mushroom tyrosinase, which catalyses the hydroxylation of tyrosine residues in protein. This permitted us to study the reactions of PB-DOPA in the virtual absence

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23

van Laar, Teus, and Ad Hovestadt. "Continuous Drug Delivery with Levodopa/Carbidopa Infusion: Review and First Data of a Dutch Cohort." CNS Spectrums 13, S7 (2008): 11–14. http://dx.doi.org/10.1017/s1092852900017363.

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A duodenal levodopa (L-dopa) and carbidopa infusion has been developed to stabilize plasma levels of L-dopa, in order to reduce existing motor response fluctuations. Stable plasma levels have been shown to reduce these fluctuations significantly. A constant duodenal infusion with an L-dopa solution can improve response fluctuations, however L-dopa has very poor solubility. Only in an acidic environment can L-dopa be dissolved in large volumes. To supply 1 day of infusion with the conventional L-dopa solution, ∼4–5 liters are necessary, an inconvenience to most patients. With L-dopa/carbidopa i

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24

Goldstein, David S., Robin Stull, Graeme Eisenhofer, and John R. Gill. "Urinary excretion of dihydroxyphenylalanine and dopamine during alterations of dietary salt intake in humans." Clinical Science 76, no. 5 (1989): 517–22. http://dx.doi.org/10.1042/cs0760517.

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1. Urinary excretion of dopamine (DA) increases during dietary salt loading. The majority of urinary DA is derived from circulating dihydroxyphenylalanine (dopa). Whether the increase in urinary DA excretion during salt loading results from increased efficiency of uptake of dopa by proximal tubular cells of the kidney, facilitation of intracellular conversion of dopa to DA, or increased delivery of dopa to tubular uptake sites, has been unknown. 2. In 10 inpatient normal volunteers on a constant diet, daily excretion of dopa and DA was assessed during normal sodium intake (109 mmol/day) for 1

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25

Dimic, Dusan, Dejan Milenkovic, Zoran Markovic, and Jasmina Dimitric-Markovic. "The reactivity of dopamine precursors and metabolites towards ABTS•-: An experimental and theoretical study." Journal of the Serbian Chemical Society 84, no. 8 (2019): 877–89. http://dx.doi.org/10.2298/jsc190430050d.

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The antiradical activity of L-3,4-dihydroxyphenylalanine (L-DOPA), dihydroxyphenylacetic acid (DOPAC), homovanillic acid and tyrosine towards 2,2?-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) diammonium salt radical (ABTS?-) was investigated experimentally and theoretically by UV?Vis spectroscopy and the DFT theory. The importance of the catechol moiety for this reaction was proven due to the formation of intramolecular hydrogen bond in the formed anions and radicals. The results indicated L-DOPA and DOPAC were more potent radical scavengers than homovanillic acid and tyrosine just becau

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Daiwile, Atul P., Patricia Sullivan, Subramaniam Jayanthi, David S. Goldstein, and Jean Lud Cadet. "Sex-Specific Alterations in Dopamine Metabolism in the Brain after Methamphetamine Self-Administration." International Journal of Molecular Sciences 23, no. 8 (2022): 4353. http://dx.doi.org/10.3390/ijms23084353.

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Methamphetamine (METH) use disorder affects both sexes, with sex differences occurring in behavioral, structural, and biochemical consequences. The molecular mechanisms underlying these differences are unclear. Herein, we used a rat model to identify potential sex differences in the effects of METH on brain dopaminergic systems. Rats were trained to self-administer METH for 20 days, and a cue-induced drug-seeking test was performed on withdrawal days 3 and 30. Dopamine and its metabolites were measured in the prefrontal cortex (PFC), nucleus accumbens (NAc), dorsal striatum (dSTR), and hippoca

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Dethy, Sophie, Marie Aline Laute, Nadège Van Blercom, Philippe Damhaut, Serge Goldman, and Jerzy Hildebrand. "Microdialysis-HPLC for plasma levodopa and metabolites monitoring in parkinsonian patients." Clinical Chemistry 43, no. 5 (1997): 740–44. http://dx.doi.org/10.1093/clinchem/43.5.740.

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Abstract We used in vitro microdialysis-HPLC to determine l-3,4-dihydroxyphenylalanine (l-DOPA) and its metabolites in plasma of patients with advanced Parkinson disease. Blood samples and clinical evaluations were obtained 0, 30, 60, 90, 120, and 150 min after oral administration of carbidopa/l-DOPA (25/100 mg, 12.5/125 mg, and 50/200 mg). In vitro recoveries for l-DOPA and metabolites ranged from 22% to 36%. Linear correlation was found between metabolite concentrations in the dialysate and in the surrounding medium. There was a significant positive correlation between l-DOPA dose and plasma

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Grossman, Ehud, Aaron Hoffman, Peter C. Chang, Harry R. Keiser, and David S. Goldstein. "Increased spillover of dopa into arterial blood during dietary salt loading." Clinical Science 78, no. 4 (1990): 423–29. http://dx.doi.org/10.1042/cs0780423.

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1. We measured urinary excretion rates of dopamine (3,4-dihydroxyphenethylamine) and dopa (3,4-dihydroxyphenylalanine) and the spillover rate of dopa into arterial blood during dietary salt loading in conscious Dahl salt-sensitive and salt-resistant rats with intact or denervated kidneys. 2. Dopa spillover was calculated from the steady-state clearance of intravenously infused l-[3H]dopa and arterial levels of endogenous dopa. 3. Daily excretion rates of dopa and dopamine increased by about sixfold during salt loading in both rat strains. Bilateral renal denervation delayed these increases and

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Campbell, Roderick R. A., Brian Hasinoff, Gary Chernenko, James Barrowman, and Norman R. C. Campbell. "The effect of ferrous sulfate and pH on L-dopa absorption." Canadian Journal of Physiology and Pharmacology 68, no. 5 (1990): 603–7. http://dx.doi.org/10.1139/y90-087.

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Ferrous sulfate decreases L-dopa bioavailability in humans probably as a result of binding of L-dopa by iron in the gastrointestinal tract. This study was conducted to determine if iron by binding L-dopa decreases L-dopa absorption and to investigate the effect of different pH buffers on intestinal absorption of L-dopa in the presence and absence of ferrous sulfate. A rat model developed to examine drug absorption was used. Control animals had buffered [14C]L-dopa solutions injected into two in vivo closed segments of intestine; a 5-cm duodenal and a 5-cm proximal jejunal segment. These studie

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Hu, Shuyang, Qiuyan Shuai, Yulong Lin, Yan Fu, and Meng Li. "Chiral Fe _x Cu _y Se nanoparticles as peroxidase mimics for colorimetric detection of 3, 4-dihydroxy-phenylalanine enantiomers." Nanotechnology 33, no. 13 (2022): 135503. http://dx.doi.org/10.1088/1361-6528/ac4306.

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Abstract L-3,4-dihydroxy-phenylalanine (L-dopa) is the most widely used drug in Parkinson’s disease treatment. However, development of cost-effective and high-throughput sensors to accurate enantioselective discrimination of L-dopa and D-dopa remains challenging to date. Herein, on the basis of the peroxidase-mimic activity of chiral Fe x Cu y Se nanoparticles, we demonstrated a novel colorimetric sensor for determination of chiral dopa. The surface chiral ligand, L/D-histidine (L/D-His), endowed the nanozymes with enantioselectivity in catalyzing the oxidation of dopa enantiomers. According t

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Guerrero-Rubio, María Alejandra, Hester Sheehan, and Samuel F. Brockington. "In planta complementation of the betalain biosynthetic pathway with a bacterial dioxygenase." PLOS One 20, no. 6 (2025): e0325603. https://doi.org/10.1371/journal.pone.0325603.

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Betalains are pigments naturally produced by plants belonging to the order Caryophyllales. However, 4,5-L-DOPA-extradiol-dioxygenase (DODA), the main enzyme in their biosynthetic pathway, has also been characterized in other kingdoms including fungi or bacteria. These enzymes show few similarities with the plant enzymes at structural or kinetic levels but achieve the same activity, raising questions on their possible exchange with plant DODA enzymes and subsequent complementation in the biosynthetic pathway of betalains. In this work, we show that the DODA enzyme from the bacterium Gluconaceto

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Gori, Sadakatali S., Ajit G. Thomas, Arindom Pal, et al. "D-DOPA Is a Potent, Orally Bioavailable, Allosteric Inhibitor of Glutamate Carboxypeptidase II." Pharmaceutics 14, no. 10 (2022): 2018. http://dx.doi.org/10.3390/pharmaceutics14102018.

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Glutamate carboxypeptidase-II (GCPII) is a zinc-dependent metalloenzyme implicated in numerous neurological disorders. The pharmacophoric requirements of active-site GCPII inhibitors makes them highly charged, manifesting poor pharmacokinetic (PK) properties. Herein, we describe the discovery and characterization of catechol-based inhibitors including L-DOPA, D-DOPA, and caffeic acid, with sub-micromolar potencies. Of these, D-DOPA emerged as the most promising compound, with good metabolic stability, and excellent PK properties. Orally administered D-DOPA yielded high plasma exposures (AUCpla

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SUIKO, Masahito, Yoichi SAKAKIBARA, Hiroshi NAKAJIMA, Hiroshi SAKAIDA, and Ming-Cheh LIU. "Enzymic sulphation of dopa and tyrosine isomers by HepG2 human hepatoma cells: stereoselectivity and stimulation by Mn2+." Biochemical Journal 314, no. 1 (1996): 151–58. http://dx.doi.org/10.1042/bj3140151.

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HepG2 human hepatoma cells, labelled with [35S]sulphate in media containing L-3,4-dihydroxyphenylalanine (L-dopa), (D-dopa), DL-m-tyrosine or D-p-tyrosine, were found to produce the [35S]sulphated forms of these compounds. Addition to the labelling media of m-hydroxybenzylhydrazine, an aromatic amino acid decarboxylase inhibitor, greatly enhanced the production of L-dopa O-[35S]sulphate and Dl-m-tyrosine O-[35S]sulphate, with a concomitant decrease in the formation of dopamine O-[35S]sulphate and m-tyramine O-[35S]sulphate. With 3´-phosphoadenosine 5´-phospho[35S]sulphate as the sulphate donor

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Quiñones, Henry, Roberto Collazo, and Orson W. Moe. "The dopamine precursor l-dihydroxyphenylalanine is transported by the amino acid transporters rBAT and LAT2 in renal cortex." American Journal of Physiology-Renal Physiology 287, no. 1 (2004): F74—F80. http://dx.doi.org/10.1152/ajprenal.00237.2003.

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The intrarenal autocrine-paracrine dopamine (DA) system is critical for Na+ homeostasis. l-Dihydroxyphenylalanine (l-DOPA) uptake from the glomerular filtrate and plasma provides the substrate for DA generation by the renal proximal tubule. The transporter(s) responsible for proximal tubule l-DOPA uptake has not been characterized. Renal cortical poly-A+ RNA injected into Xenopus laevis oocytes induced l-DOPA uptake in a time- and dose-dependent fashion with biphasic Kms in the millimolar and micromolar range and independent of inward Na+, K+, or H+ gradients, suggesting the presence of low- a

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Elabi, Osama F., Elena Espa, Katrine Skovgård, Silvia Fanni, and Maria Angela Cenci. "Ropinirole Cotreatment Prevents Perivascular Glial Recruitment in a Rat Model of L-DOPA-Induced Dyskinesia." Cells 12, no. 14 (2023): 1859. http://dx.doi.org/10.3390/cells12141859.

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Dopamine replacement therapy for Parkinson’s disease is achieved using L-DOPA or dopamine D2/3 agonists, such as ropinirole. Here, we compare the effects of L-DOPA and ropinirole, alone or in combination, on patterns of glial and microvascular reactivity in the striatum. Rats with unilateral 6-hydroxydopamine lesions were treated with therapeutic-like doses of L-DOPA (6 mg/kg), an equipotent L-DOPA-ropinirole combination (L-DOPA 3 mg/kg plus ropinirole 0.5 mg/kg), or ropinirole alone. Immunohistochemistry was used to examine the reactivity of microglia (ionized calcium-binding adapter molecule

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Tesoro, Carmen, Filomena Lelario, Rosanna Ciriello, Giuliana Bianco, Angela Di Capua, and Maria Assunta Acquavia. "An Overview of Methods for L-Dopa Extraction and Analytical Determination in Plant Matrices." Separations 9, no. 8 (2022): 224. http://dx.doi.org/10.3390/separations9080224.

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L-dopa is a precursor of dopamine used as the most effective symptomatic drug treatment for Parkinson’s disease. Most of the L-dopa isolated is either synthesized chemically or from natural sources, but only some plants belonging to the Fabaceae family contain significant amounts of L-dopa. Due to its low stability, the unambiguous determination of L-dopa in plant matrices requires appropriate technologies. Several analytical methods have been developed for the determination of L-dopa in different plants. The most used for quantification of L-dopa are mainly based on capillary electrophoresis

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Fridjonsdottir, Elva, Reza Shariatgorji, Anna Nilsson, et al. "Mass spectrometry imaging identifies abnormally elevated brain l-DOPA levels and extrastriatal monoaminergic dysregulation in l-DOPA–induced dyskinesia." Science Advances 7, no. 2 (2021): eabe5948. http://dx.doi.org/10.1126/sciadv.abe5948.

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l-DOPA treatment for Parkinson’s disease frequently leads to dyskinesias, the pathophysiology of which is poorly understood. We used MALDI-MSI to map the distribution of l-DOPA and monoaminergic pathways in brains of dyskinetic and nondyskinetic primates. We report elevated levels of l-DOPA, and its metabolite 3-O-methyldopa, in all measured brain regions of dyskinetic animals and increases in dopamine and metabolites in all regions analyzed except the striatum. In dyskinesia, dopamine levels correlated well with l-DOPA levels in extrastriatal regions, such as hippocampus, amygdala, bed nucleu

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Zimlichman, Reuven, Paul D. Levinson, Gerald Kelly, Robin Stull, Harry R. Keiser, and David S. Goldstein. "Derivation of urinary dopamine from plasma dopa." Clinical Science 75, no. 5 (1988): 515–20. http://dx.doi.org/10.1042/cs0750515.

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1. We estimated the extent to which circulating dopa (3,4-dihydroxyphenylalanine) is the source of urinary dopamine (DA; 3,4-dihydroxyphenethylamine). Tritiated dopa ([3H]dopa) was infused for 90 min into the left renal artery of seven anaesthetized foxhounds, and levels of labelled and unlabelled dopa and DA were measured in the ureteral urine and in the femoral arterial and left renal venous plasma. 2. Only a small percentage of [3H]dopa delivered to the kidneys was excreted as [3H]DA (0.59% from the left kidney, 0.68% from the right); however, the arterial concentration of endogenous dopa (

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Turker, Nebiye Pelin, and Elvan Bakar. "Effects of L-dopa and p-coumaric acid combination on oxidative stress, DNA damage, and mitochondrial apoptosis in neuroblastoma cells." Bangladesh Journal of Pharmacology 18, no. 2 (2023): 49–57. https://doi.org/10.3329/bjp.v18i2.65531.

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This study aimed to investigate the effects of levodopa (L-dopa), p-coumaric acid, and combinations in the neuroblastoma (N1E-115) cell. L-dopa and L-dopa plus p-coumaric acid group caused oxidative stress by increasing 12.5 and 3.7-fold in superoxide dismutase gene, 11.5 and 4.8-fold increase in catalase gene, respectively. In L-dopa and L-dopa plus p-coumaric acid application, p21 gene expression increased 1.3-fold and 3.2-fold, and the cell cycle stopped in the G1 phase in response to stress in the treatment groups. In the application of L-dopa plus p-coumaric acid to N1E-115 cells, the BCL

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Shinde, Sagar, Athoiba Singh, Shekhar Shinde, and Jagtap Suresh. "Emerging Perspectives on Plant-Based L-Dopa Sources for the Treatment of Parkinson’s disease." Ecology, Environment and Conservation 30, no. 02 (2024): 944–52. http://dx.doi.org/10.53550/eec.2024.v30i02.087.

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L-DOPA (L-3, 4-dihydroxyphenylalanine) is a crucial pharmacological agent in the treatment of Parkinson’s disease (PD). As a precursor to dopamine, its administration serves to address the dopamine deficiency. Dopamine is a neurotransmitter and plays a prominent role for motor control and coordination is severely depleted in PD patients, leading to debilitating motor symptoms. L-DOPA crosses the blood-brain barrier, where it is converted into dopamine, While L-DOPA remains the gold standard for PD management, and this review will focus on plant-based L- DOPA sources as an alternative to synthe

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Inyushin, M. Y., A. Huertas, Y. V. Kucheryavykh, et al. "L-DOPA Uptake in Astrocytic Endfeet Enwrapping Blood Vessels in Rat Brain." Parkinson's Disease 2012 (2012): 1–8. http://dx.doi.org/10.1155/2012/321406.

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Astrocyte endfeet surround brain blood vessels and can play a role in the delivery of therapeutic drugs for Parkinson’s disease. However, there is no previous evidence of the presence of LAT transporter forL-DOPA in brain astrocytes except in culture. Using systemicL-DOPA administration and a combination of patch clamp, histochemistry and confocal microscopy we found thatL-DOPA is accumulated mainly in astrocyte cell bodies, astrocytic endfeet surrounding blood vessels, and pericytes. In brain slices: (1) astrocytes were exposed to ASP+, a fluorescent monoamine analog of MPP+; (2) ASP+taken up

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Yang, Youhui, Yingchen Wang, Zhaoguan Wang, and Hao Qi. "Efficient Incorporation of DOPA into Proteins Free from Competition with Endogenous Translation Termination Machinery." Biomolecules 15, no. 3 (2025): 382. https://doi.org/10.3390/biom15030382.

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3,4-Dihydroxy-L-phenylalanine (DOPA) is a promising noncanonical amino acid (ncAA) that introduces novel catechol chemical features into proteins, expanding their functional potential. However, the most common approach to incorporating ncAAs into proteins relies on stop codon suppression, which is often limited by the competition of endogenous translational termination machinery. Here, we employed a special in vitro protein expression system that facilitates the efficiency of DOPA incorporation into proteins by removing essential Class I peptide release factors through targeted degradation. In

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Kuo, Tung-Tai, Yuan-Hao Chen, Vicki Wang, et al. "PT320, a Sustained-Release GLP-1 Receptor Agonist, Ameliorates L-DOPA-Induced Dyskinesia in a Mouse Model of Parkinson’s Disease." International Journal of Molecular Sciences 24, no. 5 (2023): 4687. http://dx.doi.org/10.3390/ijms24054687.

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To determine the efficacy of PT320 on L-DOPA-induced dyskinetic behaviors, and neurochemistry in a progressive Parkinson’s disease (PD) MitoPark mouse model. To investigate the effects of PT320 on the manifestation of dyskinesia in L-DOPA-primed mice, a clinically translatable biweekly PT320 dose was administered starting at either 5 or 17-weeks-old mice. The early treatment group was given L-DOPA starting at 20 weeks of age and longitudinally evaluated up to 22 weeks. The late treatment group was given L-DOPA starting at 28 weeks of age and longitudinally observed up to 29 weeks. To explore d

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Fang, Lu, Hangxu Ren, Xiyu Mao, et al. "Differential Amperometric Microneedle Biosensor for Wearable Levodopa Monitoring of Parkinson’s Disease." Biosensors 12, no. 2 (2022): 102. http://dx.doi.org/10.3390/bios12020102.

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Levodopa (L-Dopa) is considered to be one of the most effective therapies available for Parkinson’s disease (PD) treatment. The therapeutic window of L-Dopa is narrow due to its short half-life, and long-time L-Dopa treatment will cause some side effects such as dyskinesias, psychosis, and orthostatic hypotension. Therefore, it is of great significance to monitor the dynamic concentration of L-Dopa for PD patients with wearable biosensors to reduce the risk of complications. However, the high concentration of interferents in the body brings great challenges to the in vivo monitoring of L-Dopa.

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Seri, I., B. C. Kone, S. R. Gullans, A. Aperia, B. M. Brenner, and B. J. Ballermann. "Locally formed dopamine inhibits Na+-K+-ATPase activity in rat renal cortical tubule cells." American Journal of Physiology-Renal Physiology 255, no. 4 (1988): F666—F673. http://dx.doi.org/10.1152/ajprenal.1988.255.4.f666.

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Dopamine, generated locally from L-dopa, inhibits Na+-K+-ATPase in permeabilized rat proximal tubules under maximum transport rate conditions for sodium. To determine whether locally formed dopamine inhibits Na+-K+-ATPase activity in intact cortical tubule cells we studied the effect of L-dopa on ouabain-sensitive oxygen consumption rate (QO2) and 86Rb uptake in renal cortical tubule cell suspensions. L-Dopa (10(-4) M) did not affect ouabain-insensitive QO2 or mitochondrial respiration. However, L-dopa inhibited ouabain-sensitive QO2 in a concentration-dependent manner, with half-maximal inhib

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Iriarte, Carmen E., and Ian G. Macreadie. "Comparison of Cytocidal Activities of L-DOPA and Dopamine in S. cerevisiae and C. glabrata." Current Bioactive Compounds 16, no. 1 (2020): 90–93. http://dx.doi.org/10.2174/1573407214666180108144216.

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Background: Parkinson's Disease results from a loss of dopaminergic neurons, and reduced levels of the neurotransmitter dopamine. Parkinson's Disease treatments involve increasing dopamine levels through administration of L-DOPA, which can cross the blood brain barrier and be converted to dopamine in the brain. The toxicity of dopamine has previously studied but there has been little study of L-DOPA toxicity. Methods: We have compared the toxicity of dopamine and L-DOPA in the yeasts, Saccharomyces cerevisiae and Candida glabrata by cell viability assays, measuring colony forming units. Result

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Miller, Dusty R., Jamie E. Spahn, and J. Herbert Waite. "The staying power of adhesion-associated antioxidant activity in Mytilus californianus." Journal of The Royal Society Interface 12, no. 111 (2015): 20150614. http://dx.doi.org/10.1098/rsif.2015.0614.

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The California mussel, Mytilus californianus , adheres in the highly oxidizing intertidal zone with a fibrous holdfast called the byssus using 3, 4-dihydroxyphenyl- l -alanine (DOPA)-containing adhesive proteins. DOPA is susceptible to oxidation in seawater and, upon oxidation, loses adhesion. Successful mussel adhesion thus depends critically on controlling oxidation and reduction. To explore how mussels regulate redox during their functional adhesive lifetime, we tracked extractable protein concentration, DOPA content and antioxidant activity in byssal plaques over time. In seawater, DOPA co

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Fiebrich, H., A. H. Brouwers, M. N. Kerstens, et al. "Sensitivity of 6-[F-18]fluoro-L-dihydroxyphenylalanine positron emission tomography for localizing tumors causing catecholamine excess." Journal of Clinical Oncology 27, no. 15_suppl (2009): 11064. http://dx.doi.org/10.1200/jco.2009.27.15_suppl.11064.

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11064 Background: Positron emission tomography (PET) using the catecholamine precursor 6-[F-18]fluoro-L-dihydroxyphenylalanine (18F-DOPA) has emerged as promising technique to localize tumors with catecholamine excess. This study investigated the sensitivity of 18F-DOPA PET, compared to 123I-metaiodobenzylguanidine (123I-MIBG) scintigraphy and computer tomography (CT)/ magnetic resonance imaging (MRI) in patients with catecholamine excess. Methods: In a single center prospective study 18F-DOPA PET was compared to 123I-MIBG and CT/MRI in patients with catecholamine excess. The performance of ea

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Ai, Penghui, Shaoqing Xu, Yuan Yuan, et al. "Targeted Gut Microbiota Modulation Enhances Levodopa Bioavailability and Motor Recovery in MPTP Parkinson’s Disease Models." International Journal of Molecular Sciences 26, no. 11 (2025): 5282. https://doi.org/10.3390/ijms26115282.

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Emerging evidence highlights the gut microbiota as a pivotal determinant of pharmacological efficacy. While Enterococcus faecalis (E. faecalis)-derived tyrosine decarboxylases (tyrDCs) are known to decarboxylate levodopa (L-dopa), compromising systemic bioavailability, the causal mechanisms underlying microbiota-mediated pharmacodynamic variability remain unresolved. In our study, we employed antibiotic-induced microbiota depletion and fecal microbiota transplantation (FMT) to interrogate microbiota-L-dopa interactions in MPTP-induced Parkinson’s disease (PD) mice. The study demonstrated that

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Winarni, Sri, and Yudhy Dharmawan. "KANDUNGAN L-DOPA DALAM VARIASI PERENDAMAN DAN PEREBUSAN DALAM PROSES PEMBUATAN TEMPE BENGUK." Jurnal Kesehatan Masyarakat 11, no. 2 (2016): 155. http://dx.doi.org/10.15294/kemas.v11i2.3489.

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<p>Abstrak</p><p>L-Dopa biji koro benguk sebesar 14,7%, berbeda dengan tempe benguk. Tujuan penelitian adalah menguji L-Dopa dalam 4 pengolahan tempe benguk yang berbeda. Penelitian tahun 2015 ini menggunakan teknik pengumpulan data dengan mengamati proses pengolahan tempe benguk dan menguji L-Dopa dalam fraksi tempe benguk dengan HPLC. Populasi penelitian adalah seluruh pemilik industri tempe benguk. Sampel penelitian diambil dengan metode purposif sampling, menentukan 4 industri tempe benguk yang sering digunakan. Proses pertama dengan satu rebusan 1-1,5 jam dan satu rendam

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