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Artykuły w czasopismach na temat „Dopamine type I receptor”

Autor: Grafiati

Data publikacji: 19 października 2024

Data aktualizacji: 31 lipca 2025

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1

Sarkar, D. K., K. Chaturvedi, S. Oomizu, N. I. Boyadjieva та C. P. Chen. "Dopamine, Dopamine D2 Receptor Short Isoform, Transforming Growth Factor (TGF)-β1, and TGF-β Type II Receptor Interact to Inhibit the Growth of Pituitary Lactotropes". Endocrinology 146, № 10 (2005): 4179–88. http://dx.doi.org/10.1210/en.2005-0430.

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The neurotransmitter dopamine is known to inhibit prolactin secretion and the proliferation of lactotropes in the pituitary gland. In this study, we determined whether dopamine and TGFβ1 interact to regulate lactotropic cell proliferation. We found that dopamine and the dopamine agonist bromocriptine stimulated TGFβ1 secretion and TGFβ1 mRNA expression but inhibited lactotropic cell proliferation both in vivo and in vitro. The dopamine’s inhibitory action on lactotropic cell proliferation was blocked by a TGFβ1-neutralizing antibody. We also found that PR1 cells, which express low amounts of t

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2

Peiser, Christian, Marcello Trevisani, David A. Groneberg, et al. "Dopamine type 2 receptor expression and function in rodent sensory neurons projecting to the airways." American Journal of Physiology-Lung Cellular and Molecular Physiology 289, no. 1 (2005): L153—L158. http://dx.doi.org/10.1152/ajplung.00222.2004.

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Agonists of the dopamine receptors have been demonstrated to have bronchodilatory properties in pathologically constricted airways. The mechanism by which these agonists induce bronchodilatation is thought to involve airway sensory nerves. In this study, the expression and function of dopamine D2 receptor were examined in sensory ganglia supplying the airways. Neuronal dopamine D2 receptor mRNA expression was demonstrated by single-cell RT-PCR following laser-assisted microdissection. The projection of the neurons to the airways was confirmed by retrograde neuronal labeling. In functional stud

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3

Myslivecek, Jaromir. "Dopamine and Dopamine-Related Ligands Can Bind Not Only to Dopamine Receptors." Life 12, no. 5 (2022): 606. http://dx.doi.org/10.3390/life12050606.

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The dopaminergic system is one of the most important neurotransmitter systems in the central nervous system (CNS). It acts mainly by activation of the D1-like receptor family at the target cell. Additionally, fine-tuning of the signal is achieved via pre-synaptic modulation by the D2-like receptor family. Some dopamine drugs (both agonists and antagonists) bind in addition to DRs also to α2-ARs and 5-HT receptors. Unfortunately, these compounds are often considered subtype(s) specific. Thus, it is important to consider the presence of these receptor subtypes in specific CNS areas as the functi

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4

Shariati, G. H., G. Ahangari, M. R. Asadi, F. Poyafard, and H. R. Ahmadkhaniha. "Dopamine Receptor Gene Expression Changes in Peripheral Blood Mononuclear Cells from Schizophrenic Patients Treated with Haloperidol and Olanzapine." European Journal of Inflammation 7, no. 2 (2009): 71–76. http://dx.doi.org/10.1177/1721727x0900700203.

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We investigated dopamine receptor gene expression in peripheral blood mononuclear cells of schizophrenic patients before and after treatment. Also dopamine receptor genes expression profile was compared in two treatment groups including haloperidol and olanzapine. The peripheral blood mononuclear cells were separated from whole blood by Ficoll-hypaque; the total cellular RNA was extracted and the cDNA was synthesized. This process was followed by real-time polymerase chain reaction using primer pairs specific for five dopamine receptor mRNAs and β-actin as internal control. The results show th

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5

Helms, My N., Xi-Juan Chen, Semra Ramosevac, Douglas C. Eaton, and Lucky Jain. "Dopamine regulation of amiloride-sensitive sodium channels in lung cells." American Journal of Physiology-Lung Cellular and Molecular Physiology 290, no. 4 (2006): L710—L722. http://dx.doi.org/10.1152/ajplung.00486.2004.

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Dopamine increases lung fluid clearance. This is partly due to activation of basolateral Na-K-ATPase. However, activation of Na-K-ATPase by itself is unlikely to produce large changes in transepithelial transport. Therefore, we examined apical and basolateral dopamine's effect on apical, highly selective sodium channels [epithelial sodium channels (ENaC)] in monolayers of an alveolar type 2 cell line (L2). Dopamine increased channel open probability ( Po) without changing the unitary current. The D1 receptor blocker SCH-23390 blocked the dopamine effect, but the D2 receptor blocker sulpiride d

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6

Ding, Guoliang, Rob F. Wiegerinck, Ming Shen, Anca Cojoc, Carlo M. Zeidenweber та Mary B. Wagner. "Dopamine increases L-type calcium current more in newborn than adult rabbit cardiomyocytes via D1 and β2 receptors". American Journal of Physiology-Heart and Circulatory Physiology 294, № 5 (2008): H2327—H2335. http://dx.doi.org/10.1152/ajpheart.00993.2007.

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Dopamine is used to treat heart failure, particularly after cardiac surgery in infants, but the mechanisms of action are unclear. We investigated differences in the effect of dopamine on L-type calcium current ( ICa) between newborn (NB, 1–4 days) and adult (AD, 3–4 mo) rabbit ventricular myocytes. Myocytes were enzymatically dissociated from NB and AD rabbit hearts. ICa was recorded by using the whole cell patch-clamp technique. mRNA levels of cardiac dopamine receptor type 1 (D1), type 2 (D2), and β-adrenergic receptors (β-ARs) were measured by real-time RT-PCR. Dopamine (100 μM) increased I

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7

MORA-FERRER, CARLOS, and VOLKER GANGLUFF. "D2-dopamine receptor blockade impairs motion detection in goldfish." Visual Neuroscience 17, no. 2 (2000): 177–86. http://dx.doi.org/10.1017/s0952523800171196.

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Under photopic illumination conditions, motion detection in goldfish is dominated by the long-wavelength-sensitive cone type (L-cone), and under scotopic conditions motion it is determined by rods (Schaerer & Neumeyer, 1996). The switch from rod-dominated to cone-dominated motion detection occurs during light adaptation. It has been suggested that dopamine acts as a neuronal light-adaptative signal. It is known that dopamine affects wavelength discrimination through D1-dopamine receptors (Mora-Ferrer & Neumeyer, 1996), and the dorsal light reflex through D1- and D2-dopamine receptors (

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8

Hayashida, Yuki, and Andrew T. Ishida. "Dopamine Receptor Activation Can Reduce Voltage-Gated Na+ Current by Modulating Both Entry Into and Recovery From Inactivation." Journal of Neurophysiology 92, no. 5 (2004): 3134–41. http://dx.doi.org/10.1152/jn.00526.2004.

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We tested whether dopamine receptor activation modulates the voltage-gated Na+ current of goldfish retinal ganglion cells, using a fast voltage-clamp amplifier, perforated-patch whole cell mode, and a physiological extracellular Na+ concentration. As found in other cells, activators of D1-type dopamine receptors and of protein kinase A reduced the amplitude of current activated by depolarizations from resting potential without altering the current kinetics or activation range. However, D1-type dopamine receptor activation also accelerated the rate of entry into inactivation during subthreshold

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9

Milienne-Petiot, Morgane, Lucianne Groenink, Arpi Minassian, and Jared W. Young. "Blockade of dopamine D1-family receptors attenuates the mania-like hyperactive, risk-preferring, and high motivation behavioral profile of mice with low dopamine transporter levels." Journal of Psychopharmacology 31, no. 10 (2017): 1334–46. http://dx.doi.org/10.1177/0269881117731162.

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Background: Patients with bipolar disorder mania exhibit poor cognition, impulsivity, risk-taking, and goal-directed activity that negatively impact their quality of life. To date, existing treatments for bipolar disorder do not adequately remediate cognitive dysfunction. Reducing dopamine transporter expression recreates many bipolar disorder mania-relevant behaviors (i.e. hyperactivity and risk-taking). The current study investigated whether dopamine D1-family receptor blockade would attenuate the risk-taking, hypermotivation, and hyperactivity of dopamine transporter knockdown mice. Methods

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10

Pedarzani, P., and J. F. Storm. "Dopamine modulates the slow Ca(2+)-activated K+ current IAHP via cyclic AMP-dependent protein kinase in hippocampal neurons." Journal of Neurophysiology 74, no. 6 (1995): 2749–53. http://dx.doi.org/10.1152/jn.1995.74.6.2749.

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1. The effects of dopamine on the slow Ca(2+)-dependent K+ current (IAHP; AHP, afterhyperpolarization) and spike frequency adaptation were studied by whole cell voltage-clamp and sharp microelectrode current-clamp recordings in rat CA1 pyramidal neurons in rat hippocampal slices. 2. Dopamine suppressed IAHP in a dose-dependent manner, under whole cell voltage-clamp conditions. Similarly, under current-clamp conditions, dopamine inhibited spike frequency adaptation and suppressed the slow afterhyperpolarization. 3. The effect of dopamine on IAHP was mimicked by a D1 receptor agonist and blocked

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11

Garcia-Garrote, Maria, Juan A. Parga, Pablo J. Labandeira, Jose Luis Labandeira-Garcia, and Jannette Rodriguez-Pallares. "Dopamine Regulates Adult Neurogenesis in the Ventricular-Subventricular Zone via Dopamine D3 Angiotensin Type 2 Receptor Interactions." Stem Cells 39, no. 12 (2021): 1778–94. http://dx.doi.org/10.1002/stem.3457.

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Abstract Adult neurogenesis is a dynamic and highly regulated process, and different studies suggest that dopamine modulates ventricular-subventricular zone (V-SVZ) neurogenesis. However, the specific role of dopamine and the mechanisms/factors underlying its effects on physiological and pathological conditions such as Parkinson's disease (PD) are not fully understood. Recent studies have described counter-regulatory interactions between renin-angiotensin system (RAS) and dopamine in peripheral tissues and in the nigrostriatal system. We have previously demonstrated that angiotensin receptors

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12

Yan, Zhen, Wen-Jie Song, and D. James Surmeier. "D2 Dopamine Receptors Reduce N-Type Ca2+ Currents in Rat Neostriatal Cholinergic Interneurons Through a Membrane-Delimited, Protein-Kinase-C-Insensitive Pathway." Journal of Neurophysiology 77, no. 2 (1997): 1003–15. http://dx.doi.org/10.1152/jn.1997.77.2.1003.

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Yan, Zhen, Wen-Jie Song, and D. James Surmeier. D2 dopamine receptors reduce N-type Ca2+ currents in rat neostriatal cholinergic interneurons through a membrane-delimited, protein-kinase-C-insensitive pathway. J. Neurophysiol. 77: 1003–1015, 1997. Dopamine has long been known to regulate the activity of striatal cholinergic interneurons and the release of acetylcholine. Yet, the cellular mechanisms by which this regulation occurs have not been elucidated. One way in which dopamine might act is by modulating voltage-dependent Ca2+ channels. To test this hypothesis, the impact of dopaminergic ag

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13

Jawad, ASMAA, and Nany Hairunisa. "Evaluation of (HbA1c, Creatinine, Dopamine receptor2, Insulin, Glutathione, Lipidperoxidase) in type 2 diabetes mellitus patients." Al-Kufa University Journal for Biology 17, no. 1 (2025): 10–15. https://doi.org/10.36320/ajb/v17.i1.17874.

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The dopamine receptor, often known as DA, is crucial in the body's regulation of insulin production. The patient group had significantly lower mean and standard deviation values for Dopamine receptors than the control group. In this study, regarding the Dopamine receptor mean (SD), patients with type 2 diabetes mellitus and control groups had values of 2.48 (1.17) and 102.71 (543.30), respectively. The insulin means (SD) for the patient and control groups were 258.0601 (44.35) and 119.8709 (37.075), respectively. The insulin concentration between the patients with type 2 diabetes mellitus and

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14

Kalinnikova, Tatiana Borisovna, Rufina Rifkatovna Kolsanova, Evgenia Borisovna Belova, Dilyara Makhmutrievna Khakimova, Marat Khamitovich Gainutdinov, and Rifgat Roaldovich Shagidullin. "The possible role of dopamine receptors DOP-1 and DOP-3 in behavior thermotolerance regulation of Caenorhabditis elegans Maupas." Samara Journal of Science 7, no. 2 (2018): 63–68. http://dx.doi.org/10.17816/snv201872112.

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The paper investigates dopamine influence on the tolerance of swimming, induced by mechanical stimulus, to the temperature of 36C during the experiments with nematodes of wild type strain N2 and mutant strains LX636 ( dop-1 ( vs101 )) and LX703 ( dop-3 ( vs106 )) with null-mutations of genes of dopamine receptors DOP-1 and DOP-3. The authors have shown that dopamine in concentrations 0,5-1,0 mM increased the behavior thermotolerance of C. elegans while in concentrations 7,5-15,0 dopamine caused its decrease. Null-mutation of dopamine receptor gene dop-3 prevented the decrease of C. elegans the

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15

Hegg, Colleen C., and Mary T. Lucero. "Dopamine Reduces Odor- and Elevated-K+-Induced Calcium Responses in Mouse Olfactory Receptor Neurons In Situ." Journal of Neurophysiology 91, no. 4 (2004): 1492–99. http://dx.doi.org/10.1152/jn.00670.2003.

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Although D2 dopamine receptors have been localized to olfactory receptor neurons (ORNs) and dopamine has been shown to modulate voltage-gated ion channels in ORNs, dopaminergic modulation of either odor responses or excitability in mammalian ORNs has not previously been demonstrated. We found that <50 μM dopamine reversibly suppresses odor-induced Ca2+ transients in ORNs. Confocal laser imaging of 300-μm-thick slices of neonatal mouse olfactory epithelium loaded with the Ca2+-indicator dye fluo-4 AM revealed that dopaminergic suppression of odor responses could be blocked by the D2 dopamine

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16

Tomassoni, Daniele, Enea Traini, Manuele Mancini, Vincenzo Bramanti, Syed Sarosh Mahdi, and Francesco Amenta. "Dopamine, vesicular transporters, and dopamine receptor expression in rat major salivary glands." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 309, no. 5 (2015): R585—R593. http://dx.doi.org/10.1152/ajpregu.00455.2014.

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The localization of dopamine stores and the expression and localization of dopamine (DAT) and vesicular monoamine transporters (VMAT) type-1 and -2 and of dopamine D1-like and D2-like receptor subtypes were investigated in rat submandibular, sublingual, and parotid salivary glands by HPLC with electrochemical detection, as well as immunochemical and immunohistochemical techniques. Male Wistar rats of 2 mo of age were used. The highest dopamine levels were measured in the parotid gland, followed by the submandibular and sublingual glands. Western blot analysis revealed DAT, VMAT-1, VMAT-2, and

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17

Tsuneki, Hiroshi, Takahiro Maeda, Mayumi Takatsuki, et al. "Bromocriptine improves glucose tolerance in obese mice via central dopamine D2 receptor-independent mechanism." PLOS ONE 20, no. 3 (2025): e0320157. https://doi.org/10.1371/journal.pone.0320157.

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Bromocriptine, generally regarded as a dopamine D2 receptor agonist, has been used to treat patients with type 2 diabetes in the USA; however, its mechanisms of action including the receptors that mediate its anti-diabetic effects remain unclear. Therefore, we herein conducted pharmacological and genetic knockout experiments to investigate how bromocriptine improves glucose metabolism under type 2 diabetic conditions. Bromocriptine transiently increased blood glucose levels in both wild-type and dopamine D2 receptor-deficient mice. This glucose-elevating effect was blocked by the α2-adrenergic

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18

Pfeiffer-Linn, C., and E. M. Lasater. "Dopamine modulates in a differential fashion T- and L-type calcium currents in bass retinal horizontal cells." Journal of General Physiology 102, no. 2 (1993): 277–94. http://dx.doi.org/10.1085/jgp.102.2.277.

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White bass (Roccus chrysops) retinal horizontal cells possess two types of voltage-activated calcium currents which have recently been characterized with regard to their voltage dependence and pharmacology (Sullivan, J., and E. M. Lasater. 1992. Journal of General Physiology. 99:85-107). A low voltage-activated transient current was identified which resembles the T-type calcium current described in a number of other preparations, along with a sustained high threshold, long-lasting calcium current that resembles the L-type calcium current. Here we report on the modulation of horizontal cell cal

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19

Morra, M., F. Leboulenger, and H. Vaudry. "Characterization of dopamine receptors associated with steroid secretion in frog adrenocortical cells." Journal of Molecular Endocrinology 8, no. 1 (1992): 43–52. http://dx.doi.org/10.1677/jme.0.0080043.

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ABSTRACT We investigated the type of receptors involved in the mechanism of action of dopamine on corticosteroid secretion from the frog interrenal (adrenal) gland, using the in-vitro perifusion technique. Exposure of dispersed interrenal cells to 50 μm dopamine for 20 min had a biphasic effect on corticosterone and aldosterone secretion, i.e. a transient stimulation followed by an inhibitory phase. Repeated administration of equimolar pulses of dopamine, given at 150-min intervals, resulted in an enhancement of corticosteroid secretion followed by a subsequent blockade of the stimulatory phas

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20

Cui, Qiaoling, Qian Li, Hongyan Geng, et al. "Dopamine receptors mediate strategy abandoning via modulation of a specific prelimbic cortex–nucleus accumbens pathway in mice." Proceedings of the National Academy of Sciences 115, no. 21 (2018): E4890—E4899. http://dx.doi.org/10.1073/pnas.1717106115.

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The ability to abandon old strategies and adopt new ones is essential for survival in a constantly changing environment. While previous studies suggest the importance of the prefrontal cortex and some subcortical areas in the generation of strategy-switching flexibility, the fine neural circuitry and receptor mechanisms involved are not fully understood. In this study, we showed that optogenetic excitation and inhibition of the prelimbic cortex–nucleus accumbens (NAc) pathway in the mouse respectively enhances and suppresses strategy-switching ability in a cross-modal spatial-egocentric task.

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21

Frankowska, Małgorzata, Joanna Miszkiel, Lucyna Pomierny-Chamioło, et al. "Alternation in dopamine D2-like and metabotropic glutamate type 5 receptor density caused by differing housing conditions during abstinence from cocaine self-administration in rats." Journal of Psychopharmacology 33, no. 3 (2019): 372–82. http://dx.doi.org/10.1177/0269881118821113.

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Background: Environmental conditions have an important function in substance use disorder, increasing or decreasing the risks of relapse. Several studies strongly support the role of the dopamine D2-like and metabotropic glutamate type 5 receptors in maladaptive neurobiological responses to cocaine reward and relapse. Aims: The present study employed cocaine self-administration with yoked-triad procedure in rats to explore whether drug abstinence in different housing conditions affects the drug-seeking behaviour and the dopamine D2-like and metabotropic glutamate type 5 receptor density and af

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22

Yang, Zhiwei, Laureano D. Asico, Peiying Yu, et al. "D5 dopamine receptor regulation of phospholipase D." American Journal of Physiology-Heart and Circulatory Physiology 288, no. 1 (2005): H55—H61. http://dx.doi.org/10.1152/ajpheart.00627.2004.

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D1-like receptors have been reported to decrease oxidative stress in vascular smooth muscle cells by decreasing phospholipase D (PLD) activity. However, the PLD isoform regulated by D1-like receptors (D1 or D5) and whether abnormal regulation of PLD by D1-like receptors plays a role in the pathogenesis of hypertension are unknown. The hypothesis that the D5 receptor is the D1-like receptor that inhibits PLD activity and serves to regulate blood pressure was tested using D5 receptor mutant mice (D5−/−). We found that in the mouse kidney, PLD2, like the D5 receptor, is mainly expressed in renal

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23

Kovtun, Oleg, Ruben Torres, Laurel G. Bellocchio, and Sandra Jean Rosenthal. "Membrane Nanoscopic Organization of D2L Dopamine Receptor Probed by Quantum Dot Tracking." Membranes 11, no. 8 (2021): 578. http://dx.doi.org/10.3390/membranes11080578.

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The role of lateral mobility and nanodomain organization of G protein-coupled receptors in modulating subcellular signaling has been under increasing scrutiny. Investigation of D2 dopamine receptor diffusion dynamics is of particular interest, as these receptors have been linked to altered neurotransmission in affective disorders and represent the primary target for commonly prescribed antipsychotics. Here, we applied our single quantum dot tracking approach to decipher intrinsic diffusion patterns of the wild-type long isoform of the D2 dopamine receptor and its genetic variants previously id

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Davila, Nestor G., Laura J. Blakemore, and Paul Q. Trombley. "Dopamine Modulates Synaptic Transmission Between Rat Olfactory Bulb Neurons in Culture." Journal of Neurophysiology 90, no. 1 (2003): 395–404. http://dx.doi.org/10.1152/jn.01058.2002.

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The glomerular layer of the olfactory bulb (OB) contains synaptic connections between olfactory sensory neurons and OB neurons as well as connections among OB neurons. A subpopulation of external tufted cells and periglomerular cells (juxtaglomerular neurons) expresses dopamine, and recent reports suggest that dopamine can inhibit olfactory sensory neuron activation of OB neurons. In this study, whole cell electrophysiological and primary culture techniques were employed to characterize the neuromodulatory properties of dopamine on glutamatergic transmission between rat OB mitral/tufted (M/T)

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Günther, Thomas, Michael Culler, and Stefan Schulz. "Research Resource: Real-Time Analysis of Somatostatin and Dopamine Receptor Signaling in Pituitary Cells Using a Fluorescence-Based Membrane Potential Assay." Molecular Endocrinology 30, no. 4 (2016): 479–90. http://dx.doi.org/10.1210/me.2015-1241.

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Stable somatostatin analogues and dopamine receptor agonists are the mainstay for the pharmacological treatment of functional pituitary adenomas; however, only a few cellular assays have been developed to detect receptor activation of novel compounds without disrupting cells to obtain the second messenger content. Here, we adapted a novel fluorescence-based membrane potential assay to characterize receptor signaling in a time-dependent manner. This minimally invasive technique provides a robust and reliable read-out for ligand-induced receptor activation in permanent and primary pituitary cell

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Shultz, P. J., J. R. Sedor, and H. E. Abboud. "Dopaminergic stimulation of cAMP accumulation in cultured rat mesangial cells." American Journal of Physiology-Heart and Circulatory Physiology 253, no. 2 (1987): H358—H364. http://dx.doi.org/10.1152/ajpheart.1987.253.2.h358.

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Dopamine (DA) alters renal hemodynamics, and DA receptors have been demonstrated in isolated glomeruli. To determine the glomerular cell type bearing DA receptors, we studied the effect of dopaminergic agonists and antagonists on adenosine 3',5'-cyclic monophosphate (cAMP) accumulation in rat glomerular mesangial and epithelial cells in culture. DA caused a marked dose- and time-dependent increase in cAMP accumulation in mesangial but not epithelial cells. The stimulatory effect of DA was abolished by the DA antagonists haloperidol, trifluoperazine, and cis-thiothixene but not by beta- or alph

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Zheng, Hong, Xuefei Liu, Yulong Li, Paras K. Mishra, and Kaushik P. Patel. "Attenuated dopaminergic tone in the paraventricular nucleus contributing to sympathoexcitation in rats with Type 2 diabetes." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 306, no. 2 (2014): R138—R148. http://dx.doi.org/10.1152/ajpregu.00323.2013.

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The study was conducted to investigate the role for dopamine in the centrally mediated sympathoexcitatory response in rats with Type 2 diabetes (T2D). T2D was induced by a combination of high-fat diet (HFD) and low-dose streptozotocin (STZ). HFD/STZ treatment for 12–14 wk resulted in significant increase in the number of FosB-positive cells in the paraventricular nucleus (PVN) and rostral ventrolateral medulla (RVLM). In anesthetized rats, administration of exogenous dopamine (dopamine hydrochloride, 20 mM) in the PVN, but not in the RVLM, elicited decreases in renal sympathetic nerve activity

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Brunig, I., M. Sommer, H. Hatt, and J. Bormann. "Dopamine receptor subtypes modulate olfactory bulb -aminobutyric acid type A receptors." Proceedings of the National Academy of Sciences 96, no. 5 (1999): 2456–60. http://dx.doi.org/10.1073/pnas.96.5.2456.

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Thornberg, Sheri A., and Larry Ereshefsky. "Neuroleptic Malignant Syndrome Associated With Clozapine Monotherapy." Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy 13, no. 5 (1993): 510–14. http://dx.doi.org/10.1002/j.1875-9114.1993.tb04317.x.

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Neuroleptic malignant syndrome is thought to be a result of dopamine receptor blockade in the striatum. Clozapine has only weak affinity for dopamine type 1 and 2 receptors, and therefore it was thought this drug would not precipitate the syndrome. However, six cases of the syndrome have been reported in patients receiving clozapine monotherapy. A review of the pathoetiology of symptoms occurring in the syndrome is included.

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Carroll, J. L., K. M. Boyle, M. J. Wasicko, and L. M. Sterni. "Dopamine D2 receptor modulation of carotid body type 1 cell intracellular calcium in developing rats." American Journal of Physiology-Lung Cellular and Molecular Physiology 288, no. 5 (2005): L910—L916. http://dx.doi.org/10.1152/ajplung.00414.2003.

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Carotid chemoreceptor type 1 cells release dopamine, which inhibits carotid chemoreceptor activity via dopamine D2 autoreceptors on type 1 cells. Postnatal changes in dopaminergic modulation may be involved in postnatal chemoreceptor development. The present study explores dopaminergic modulation of the intracellular calcium ([Ca2+]i) response to hypoxia in type 1 cells from 1, 3, and 11- to 16-day-old rats. Using fura-2, we studied the effects of quinpirole, a D2 receptor agonist, on type 1 cell [Ca2+]i response to 90-s hypoxia challenges (Po2 ∼1–2 mmHg). Cells were sequentially exposed to th

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Umemiya, Masashi, and Lynn A. Raymond. "Dopaminergic Modulation of Excitatory Postsynaptic Currents in Rat Neostriatal Neurons." Journal of Neurophysiology 78, no. 3 (1997): 1248–55. http://dx.doi.org/10.1152/jn.1997.78.3.1248.

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Umemiya, Masashi and Lynn A. Raymond. Dopaminergic modulation of excitatory postsynaptic currents in rat neostriatal neurons. J. Neurophysiol. 78: 1248–1255, 1997. γ-aminobutyric acid (GABA)-containing medium spiny neurons constitute ∼90% of the neuronal population in the neostriatum (caudate and putamen) and play an important role in motor programming. Cortical glutamatergic afferents provide the main excitatory drive for these neurons, whereas nigral dopaminergic neurons play a crucial role in regulating their activity. To further investigate the mechanisms underlying the dopaminergic modula

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Marwaha, Aditi, Anees Ahmad Banday, and Mustafa F. Lokhandwala. "Reduced renal dopamine D1 receptor function in streptozotocin-induced diabetic rats." American Journal of Physiology-Renal Physiology 286, no. 3 (2004): F451—F457. http://dx.doi.org/10.1152/ajprenal.00227.2003.

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Dopamine, via activation of renal D1 receptors, inhibits the activities of Na-K-ATPase and Na/H exchanger and subsequently increases sodium excretion. Decreased renal dopamine production and sodium excretion are associated with type I diabetes. However, it is not known whether the response to D1 receptor activation is altered in type I diabetes. The present study was designed to examine the effect of streptozotocin-induced type I diabetes on renal D1 receptor expression and function. Streptozotocin treatment of Sprague-Dawley rats caused a fourfold increase in plasma levels of glucose along wi

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Bhagwanth, Swapna, Ram K. Mishra, and Rodney L. Johnson. "Development of peptidomimetic ligands of Pro-Leu-Gly-NH2 as allosteric modulators of the dopamine D2 receptor." Beilstein Journal of Organic Chemistry 9 (January 30, 2013): 204–14. http://dx.doi.org/10.3762/bjoc.9.24.

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A variety of stable, small-molecule peptidomimetic ligands have been developed to elucidate the mechanism by which the neuropeptide Pro-Leu-Gly-NH2 (PLG) modulates dopaminergic neurotransmission. Photoaffinity labeling ligands based upon PLG peptidomimetics have been used to establish that PLG binds to the D2 dopamine receptor at a site that is different from the orthosteric site, thus making PLG and its peptidomimetics allosteric modulators of the dopamine receptor. Through the design, synthesis and pharmacological evaluation of conformationally constrained peptidomimetics containing lactam,

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Enzensperger, Christoph, and Jochen Lehmann. "Dopamine/Serotonin Receptor Ligands. 131: Homologization of a Benzindoloazecine-Type Dopamine Receptor Antagonist Modulates the Affinities for Dopamine D1−D5Receptors." Journal of Medicinal Chemistry 49, no. 21 (2006): 6408–11. http://dx.doi.org/10.1021/jm060213k.

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Kawahata, Ichiro, Tomoki Sekimori, Haoyang Wang та ін. "Dopamine D2 Long Receptors Are Critical for Caveolae-Mediated α-Synuclein Uptake in Cultured Dopaminergic Neurons". Biomedicines 9, № 1 (2021): 49. http://dx.doi.org/10.3390/biomedicines9010049.

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α-synuclein accumulation into dopaminergic neurons is a pathological hallmark of Parkinson’s disease. We previously demonstrated that fatty acid-binding protein 3 (FABP3) is critical for α-synuclein uptake and propagation to accumulate in dopaminergic neurons. FABP3 is abundant in dopaminergic neurons and interacts with dopamine D2 receptors, specifically the long type (D2L). Here, we investigated the importance of dopamine D2L receptors in the uptake of α-synuclein monomers and their fibrils. We employed mesencephalic neurons derived from dopamine D2L−/−, dopamine D2 receptor null (D2 null),

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Kawahata, Ichiro, Tomoki Sekimori, Haoyang Wang та ін. "Dopamine D2 Long Receptors Are Critical for Caveolae-Mediated α-Synuclein Uptake in Cultured Dopaminergic Neurons". Biomedicines 9, № 1 (2021): 49. http://dx.doi.org/10.3390/biomedicines9010049.

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α-synuclein accumulation into dopaminergic neurons is a pathological hallmark of Parkinson’s disease. We previously demonstrated that fatty acid-binding protein 3 (FABP3) is critical for α-synuclein uptake and propagation to accumulate in dopaminergic neurons. FABP3 is abundant in dopaminergic neurons and interacts with dopamine D2 receptors, specifically the long type (D2L). Here, we investigated the importance of dopamine D2L receptors in the uptake of α-synuclein monomers and their fibrils. We employed mesencephalic neurons derived from dopamine D2L−/−, dopamine D2 receptor null (D2 null),

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Chen, X., and T. C. Westfall. "Modulation of intracellular calcium transients and dopamine release by neuropeptide Y in PC-12 cells." American Journal of Physiology-Cell Physiology 266, no. 3 (1994): C784—C793. http://dx.doi.org/10.1152/ajpcell.1994.266.3.c784.

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In PC-12 cells differentiated with nerve growth factor, neuropeptide Y (NPY) potentiated the K(+)-evoked increase in intracellular calcium, but this potentiation was not mediated by classical Y1 or Y2 NPY receptors. The potentiation by NPY appeared to occur through the mobilization of calcium from intracellular stores because thapsigargin successfully blocked the potentiation. In contrast, the Y2 agonist, NPY-(13-36), attenuated the K(+)-evoked increase in intracellular calcium by decreasing the influx of extracellular calcium. The effect of NPY-(13-36) on dopamine release from PC-12 cells was

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Sung, Yun-Min, Angela D. Wilkins, Gustavo J. Rodriguez, Theodore G. Wensel, and Olivier Lichtarge. "Intramolecular allosteric communication in dopamine D2 receptor revealed by evolutionary amino acid covariation." Proceedings of the National Academy of Sciences 113, no. 13 (2016): 3539–44. http://dx.doi.org/10.1073/pnas.1516579113.

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The structural basis of allosteric signaling in G protein-coupled receptors (GPCRs) is important in guiding design of therapeutics and understanding phenotypic consequences of genetic variation. The Evolutionary Trace (ET) algorithm previously proved effective in redesigning receptors to mimic the ligand specificities of functionally distinct homologs. We now expand ET to consider mutual information, with validation in GPCR structure and dopamine D2 receptor (D2R) function. The new algorithm, called ET-MIp, identifies evolutionarily relevant patterns of amino acid covariations. The improved pr

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Ennis, Riley Charles, Laureano D. Asico, Ines Armando та ін. "Dopamine D1-like receptors regulate the α1A-adrenergic receptor in human renal proximal tubule cells and D1-like dopamine receptor knockout mice". American Journal of Physiology-Renal Physiology 307, № 11 (2014): F1238—F1248. http://dx.doi.org/10.1152/ajprenal.00119.2014.

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The homeostatic control of blood pressure hinges upon the delicate balance between prohypertensinogenic and antihypertensinogenic systems. D1-like dopamine receptors [dopamine D1 and D5 receptors (D1Rs and D5Rs, respectively)] and the α1A-adrenergic receptor (α1A-AR) are expressed in the renal proximal tubule and engender opposing effects on Na+ transport, i.e., natriuresis (via D1Rs and D5Rs) or antinatriuresis (via α1A-ARs). We tested the hypothesis that the D1R/D5R regulates the α1A-AR. D1-like dopamine receptors coimmunoprecipitated, colocalized, and cofractionated with α1A-ARs in lipid ra

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Robaa, Dina, Christoph Enzensperger, Shams El Din Abul Azm, El Sayeda El Khawass, Ola El Sayed, and Jochen Lehmann. "Dopamine Receptor Ligands. Part 18:(1) Modification of the Structural Skeleton of Indolobenzazecine-Type Dopamine Receptor Antagonists." Journal of Medicinal Chemistry 53, no. 6 (2010): 2646–50. http://dx.doi.org/10.1021/jm901291r.

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Helms, My N., Julie Self, Hui Fang Bao, Lauren C. Job, Lucky Jain, and Douglas C. Eaton. "Dopamine activates amiloride-sensitive sodium channels in alveolar type I cells in lung slice preparations." American Journal of Physiology-Lung Cellular and Molecular Physiology 291, no. 4 (2006): L610—L618. http://dx.doi.org/10.1152/ajplung.00426.2005.

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Active Na+ reabsorption by alveolar epithelial cells generates the driving force used to clear fluids from the air space. Using single-channel methods, we examined epithelial Na+ channel (ENaC) activity of alveolar type I (AT1) cells from live 250- to 300-μm sections of lung tissue, circumventing concerns that protracted cell isolation procedures might compromise the innate transport properties of native lung cells. We used fluorescein-labeled Erythrina crystagalli lectin to positively identify AT1 cells for single-channel patch-clamp analysis. We demonstrated, for the first time, single-chann

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Recouvreux, M. Victoria, M. Clara Guida, Daniel B. Rifkin, Damasia Becu-Villalobos та Graciela Díaz-Torga. "Active and Total Transforming Growth Factor-β1 Are Differentially Regulated by Dopamine and Estradiol in the Pituitary". Endocrinology 152, № 7 (2011): 2722–30. http://dx.doi.org/10.1210/en.2010-1464.

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Dopamine, acting through the dopamine type 2 receptor (Drd2), is the main inhibitor of pituitary prolactin (PRL) secretion and lactotroph proliferation. TGF-β1 is involved, at least in part, in mediating these actions. It was described that TGF-β1 synthesis in rat pituitary lactotrophs is up-regulated by dopamine and down-regulated by estradiol. TGF-β1 is secreted as a large latent complex. The local regulation of cytokine activation in the pituitary has not yet been explored. In this work, we studied pituitary active and total TGF-β1 content, as well as TGF-β1 mRNA, and the in vivo role of do

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Anastasiades, Paul G., Christina Boada, and Adam G. Carter. "Cell-Type-Specific D1 Dopamine Receptor Modulation of Projection Neurons and Interneurons in the Prefrontal Cortex." Cerebral Cortex 29, no. 7 (2018): 3224–42. http://dx.doi.org/10.1093/cercor/bhy299.

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Abstract Dopamine modulation in the prefrontal cortex (PFC) mediates diverse effects on neuronal physiology and function, but the expression of dopamine receptors at subpopulations of projection neurons and interneurons remains unresolved. Here, we examine D1 receptor expression and modulation at specific cell types and layers in the mouse prelimbic PFC. We first show that D1 receptors are enriched in pyramidal cells in both layers 5 and 6, and that these cells project to intratelencephalic targets including contralateral cortex, striatum, and claustrum rather than to extratelencephalic struct

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Vaz de Castro, Pedro Alves Soares, Pedro A. Jose, and Ana Cristina Simões e Silva. "Interactions between the intrarenal dopaminergic and the renin–angiotensin systems in the control of systemic arterial pressure." Clinical Science 136, no. 16 (2022): 1205–27. http://dx.doi.org/10.1042/cs20220338.

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Abstract Systemic arterial hypertension is one of the leading causes of morbidity and mortality in the general population, being a risk factor for many cardiovascular diseases. Although its pathogenesis is complex and still poorly understood, some systems appear to play major roles in its development. This review aims to update the current knowledge on the interaction of the intrarenal renin–angiotensin system (RAS) and dopaminergic system in the development of hypertension, focusing on recent scientific hallmarks in the field. The intrarenal RAS, composed of several peptides and receptors, ha

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Li, Chenhao, Yang Li, Wenwen Zhang, et al. "Dopaminergic Projections from the Hypothalamic A11 Nucleus to the Spinal Trigeminal Nucleus Are Involved in Bidirectional Migraine Modulation." International Journal of Molecular Sciences 24, no. 23 (2023): 16876. http://dx.doi.org/10.3390/ijms242316876.

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Clinical imaging studies have revealed that the hypothalamus is activated in migraine patients prior to the onset of and during headache and have also shown that the hypothalamus has increased functional connectivity with the spinal trigeminal nucleus. The dopaminergic system of the hypothalamus plays an important role, and the dopamine-rich A11 nucleus may play an important role in migraine pathogenesis. We used intraperitoneal injections of glyceryl trinitrate to establish a model of acute migraine attack and chronicity in mice, which was verified by photophobia experiments and von Frey expe

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Salyer, Sarah, Nina Lesousky, Edward J. Weinman, Barbara J. Clark, Eleanor D. Lederer, and Syed J. Khundmiri. "Dopamine regulation of Na+-K+-ATPase requires the PDZ-2 domain of sodium hydrogen regulatory factor-1 (NHERF-1) in opossum kidney cells." American Journal of Physiology-Cell Physiology 300, no. 3 (2011): C425—C434. http://dx.doi.org/10.1152/ajpcell.00357.2010.

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Na+-K+-ATPase activity in renal proximal tubule is regulated by several hormones including parathyroid hormone (PTH) and dopamine. The current experiments explore the role of Na+/H+ exchanger regulatory factor 1 (NHERF-1) in dopamine-mediated regulation of Na+-K+-ATPase. We measured dopamine regulation of ouabain-sensitive 86Rb uptake and Na+-K+-ATPase α1 subunit phosphorylation in wild-type opossum kidney (OK) (OK-WT) cells, OKH cells (NHERF-1-deficient), and OKH cells stably transfected with full-length human NHERF-1 (NF) or NHERF-1 constructs with mutated PDZ-1 (Z1) or PDZ-2 (Z2) domains. T

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Boritzki, Vanessa, Harald Hübner, Anni Allikalt, Peter Gmeiner, and Birgitta M. Wöhrl. "Optimizing the Expression of Human Dopamine Receptors in Escherichia coli." International Journal of Molecular Sciences 22, no. 16 (2021): 8647. http://dx.doi.org/10.3390/ijms22168647.

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The human dopamine receptors D2S and D3 belong to the group of G protein-coupled receptors (GPCRs) and are important drug targets. Structural analyses and development of new receptor subtype specific drugs have been impeded by low expression yields or receptor instability. Fusing the T4 lysozyme into the intracellular loop 3 improves crystallization but complicates conformational studies. To circumvent these problems, we expressed the human D2S and D3 receptors in Escherichia coli using different N- and C-terminal fusion proteins and thermostabilizing mutations. We optimized expression times a

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Stokholm, Kathrine, Majken Borup Thomsen, Jenny-Ann Phan та ін. "α-Synuclein Overexpression Increases Dopamine D2/3 Receptor Binding and Immune Activation in a Model of Early Parkinson’s Disease". Biomedicines 9, № 12 (2021): 1876. http://dx.doi.org/10.3390/biomedicines9121876.

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Progressive degeneration of dopaminergic neurons, immune activation, and α-synuclein pathology characterize Parkinson’s disease (PD). We previously reported that unilateral intranigral injection of recombinant adeno-associated viral (rAAV) vectors encoding wild-type human α-synuclein produced a rat model of early PD with dopamine terminal dysfunction. Here we tested the hypothesis that decreases in dopamine result in increased postsynaptic dopamine D2/D3 receptor expression, neuroinflammation, and reduced synaptic vesicle glycoprotein 2A (SV2A) density. Rats were injected with rAAV encoding α-

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Broft, Allegra, Mark Slifstein, Joseph Osborne, et al. "Striatal dopamine type 2 receptor availability in anorexia nervosa." Psychiatry Research: Neuroimaging 233, no. 3 (2015): 380–87. http://dx.doi.org/10.1016/j.pscychresns.2015.06.013.

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Shukla, R., VK Khanna, P. Vinod, ML Sankhwar, and RS Yadav. "Platelet Dopamine: D2 Receptor Binding in Patients with Migraine." Cephalalgia 29, no. 5 (2009): 532–38. http://dx.doi.org/10.1111/j.1468-2982.2008.01760.x.

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Clinical, genetic and pharmacological evidences suggest an abnormality of the dopaminergic system in the pathogenesis of migraine. Direct evidence of an abnormal metabolism of dopamine in migraine, however, is lacking. Platelets are a useful model to understand brain dopaminergic mechanisms. The present study has been undertaken to study the status of platelet dopamine receptor binding by carrying out radioligand receptor binding assay. Binding of 3H-spiperone to platelet membranes, known to label dopamine (DA)—D2 receptors, was conducted in 20 patients with migraine and an equal number of hea

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