Zaloguj się

Gotowe bibliografie tematyczne / Drug mixture / Rozprawy doktorskie

Kliknij ten link, aby zobaczyć inne rodzaje publikacji na ten temat: Drug mixture.

Rozprawy doktorskie na temat „Drug mixture”

Autor: Grafiati

Data publikacji: 3 czerwca 2025

Data aktualizacji: 31 lipca 2025

Utwórz poprawne odniesienie w stylach APA, MLA, Chicago, Harvard i wielu innych

Wybierz rodzaj źródła:

Sprawdź 44 najlepszych rozpraw doktorskich naukowych na temat „Drug mixture”.

Przycisk „Dodaj do bibliografii” jest dostępny obok każdej pracy w bibliografii. Użyj go – a my automatycznie utworzymy odniesienie bibliograficzne do wybranej pracy w stylu cytowania, którego potrzebujesz: APA, MLA, Harvard, Chicago, Vancouver itp.

Możesz również pobrać pełny tekst publikacji naukowej w formacie „.pdf” i przeczytać adnotację do pracy online, jeśli odpowiednie parametry są dostępne w metadanych.

Przeglądaj rozprawy doktorskie z różnych dziedzin i twórz odpowiednie bibliografie.

1

Bello, Hussaini. "Physiochemical and drug release properties of liquisolid formulations in comparison to their physical mixture counterparts." Thesis, University of Wolverhampton, 2018. http://hdl.handle.net/2436/621794.

Pełny tekst źródła

Streszczenie:

Various techniques have been used for modifying the release properties of drugs over the past years. Techniques such as liquisolid technology have raised a lot of interest in many researchers which can be employed to enhance or sustain dissolution. Various liquisolid (LS) tablets of diltiazem containing Polysorbate 80 as a non-volatile solvent for sustained release were prepared. PolyoxTM is an attractive pharmaceutical polymer used in controlled release dosage forms mainly because of its insensitivity to the pH of the biological medium and ease of production. The aim of this study was to inve

Style APA, Harvard, Vancouver, ISO itp.

2

Fransén, Nelly. "Studies on a Novel Powder Formulation for Nasal Drug Delivery." Doctoral thesis, Uppsala universitet, Institutionen för farmaci, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-9292.

Pełny tekst źródła

Streszczenie:

Nasal administration has potential for the treatment of indications requiring a fast onset of effect or for drugs with low oral bioavailability. Liquid nasal sprays are relatively common, but can be associated with suboptimal absorption from the nasal cavity; this thesis shows that nasal absorption can be significantly enhanced with a dry powder formulation. It was shown that interactive mixtures, consisting of fine drug particles adhered to the surface of mucoadhesive carrier particles, could be created in a particle size suitable for nasal administration. Sodium starch glycolate (SSG), a com

Style APA, Harvard, Vancouver, ISO itp.

3

Lajhar, Fathi. "Electrospray for pulmonary drug delivery." Thesis, University of Manchester, 2018. https://www.research.manchester.ac.uk/portal/en/theses/electrospray-for-pulmonary-drug-delivery(b8aeaea9-9032-40f5-a8e0-b51c1ba8c8f8).html.

Pełny tekst źródła

Streszczenie:

Drug administration through the pulmonary route is an ancient technique that evolved from inhaling the smoke of certain leaves as a medicine. The optimum droplet diameter for the pulmonary system deposition has been identified to be in the range from 2 to 3.5 μm, with potential deposition rates of up to 80% of this size range. Currently, the most used aerosol generator methods are the pressurized metered dose inhalers. However, they generally exhibit low deposition efficiency with less than 20 % of the spray reaching the target area of the lungs as most of the drug deposited in the upper airwa

Style APA, Harvard, Vancouver, ISO itp.

4

Cahill, Paul. "Latest variable mixture modelling : an examination of the influences and profiles of treated drug misuse in the Republic of Ireland." Thesis, University of Ulster, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.421741.

Pełny tekst źródła

Style APA, Harvard, Vancouver, ISO itp.

5

Yu, Li. "Tau-Path Test - A Nonparametric Test For Testing Unspecified Subpopulation Monotone Association." The Ohio State University, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=osu1255657068.

Pełny tekst źródła

Style APA, Harvard, Vancouver, ISO itp.

6

Duque, Marcelo Dutra. "Otimização da liberação de difosfato de primaquina em comprimidos de liberação controlada." Universidade de São Paulo, 2009. http://www.teses.usp.br/teses/disponiveis/9/9139/tde-17122009-141558/.

Pełny tekst źródła

Streszczenie:

O presente trabalho teve como objetivo produzir comprimidos de liberação controlada de difosfato de primaquina baseados em polímeros hidrofílicos e otimizar a liberação do fármaco por meio do planejamento estatístico de mistura (DOE). Na seleção dos componentes da formulação foram realizados estudos de calorimetria exploratória diferencial (DSC) para verificar a compatibilidade entre o fármaco/excipientes e avaliação do fluxo dos pós das formulações por meio da determinação do ângulo de repouso. As 20 formulações obtidas no planejamento experimental continham misturas de hidroxipropilmetilcelu

Style APA, Harvard, Vancouver, ISO itp.

7

Bredenberg, Susanne. "New Concepts in Administration of Drugs in Tablet Form : Formulation and Evaluation of a Sublingual Tablet for Rapid Absorption, and Presentation of an Individualised Dose Administration System." Doctoral thesis, Uppsala University, Department of Pharmacy, 2003. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3433.

Pełny tekst źródła

Streszczenie:

<p>This thesis presents two new concepts in oral drug administration and the results of evaluation of some relevant formulation factors.</p><p>Investigation into improving the homogeneity of mixtures for tableting indicated that it may be possible to obtain interactive dry mixtures of micronised drugs containing drug proportions as low as 0.015% w/w. By studying the relationship between disintegration time and tensile strength, it was found that the microstructure surrounding the disintegrant particles may influence the disintegration process. Therefore, avoidance of excipients which are highl

Style APA, Harvard, Vancouver, ISO itp.

8

Paudel, Liladhar. "High Field ¹H Nuclear Magnetic Resonance (NMR) Spectroscopy Based Metabolomics and Complex Mixture Analysis by Multidimensional NMR and Liquid Chromatography-Mass Spectrometry (LC-MS)." University of Akron / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=akron1343403647.

Pełny tekst źródła

Style APA, Harvard, Vancouver, ISO itp.

9

Bramer, Tobias. "Prolonged Drug Release from Gels, using Catanionic Mixtures." Doctoral thesis, Uppsala University, Department of Pharmacy, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-8303.

Pełny tekst źródła

Streszczenie:

<p>The use of catanionic drug-surfactant mixtures was proven to be an efficient novel method of obtaining prolonged drug release from gels. It was shown that various commonly used drug compounds are able to form catanionic mixtures together with oppositely charged surfactants. These mixtures exhibited interesting phase behaviour, where, among other structures, vesicles and large worm-like or branched micelles were found. The size of these aggregates makes them a potential means of prolonging the drug release from gels, as only monomer drugs in equilibrium with larger aggregates were readily ab

Style APA, Harvard, Vancouver, ISO itp.

10

Kassem, Nuha Mohammed. "Generation of deeply inspirable clouds from dry powder mixtures." Thesis, King's College London (University of London), 1990. https://kclpure.kcl.ac.uk/portal/en/theses/generation-of-deeply-inspirable-clouds-from-dry-powder-mixtures(b714bb92-b27a-4ff0-81fa-8a44d9c58d2d).html.

Pełny tekst źródła

Style APA, Harvard, Vancouver, ISO itp.

11

Wakerly, M. G. "Self-emulsifying drug delivery systems based on nonionic surfactant-oil mixtures." Thesis, University of Bath, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.235402.

Pełny tekst źródła

Style APA, Harvard, Vancouver, ISO itp.

12

Assaf, Shereen Mashhour T. "Novel vesicles from surfactant mixtures for use in topical drug delivery." Thesis, University of Strathclyde, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.249032.

Pełny tekst źródła

Style APA, Harvard, Vancouver, ISO itp.

13

White, Julie-Anne Wendy. "Pharmacological and behavioural variables in the discrimination of drug mixtures in rats." Thesis, King's College London (University of London), 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.321957.

Pełny tekst źródła

Style APA, Harvard, Vancouver, ISO itp.

14

Estejab, Bahareh. "Hydrodynamic and gasification behavior of coal and biomass fluidized beds and their mixtures." Diss., Virginia Tech, 2016. http://hdl.handle.net/10919/79366.

Pełny tekst źródła

Streszczenie:

In this study, efforts ensued to increase our knowledge of fluidization and gasification behavior of Geldart A particles using CFD. An extensive Eulerian-Eulerian numerical study was executed and simulations were compared and validated with experiments conducted at Utah State University. In order to improve numerical predictions using an Eulerian-Eulerian model, drag models were assessed to determine if they were suitable for fine particles classified as Geldart A. The results proved that if static regions of mass in fluidized beds are neglected, most drag models work well with Geldart A parti

Style APA, Harvard, Vancouver, ISO itp.

15

Lalonde, Matthew Scott. "HIV Drug Resistance Polymorphism Analysis Using Ligase Discrimination." Case Western Reserve University School of Graduate Studies / OhioLINK, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=case1244059520.

Pełny tekst źródła

Style APA, Harvard, Vancouver, ISO itp.

16

Dawson, Kathryn S. "Statistical Methods for Detecting and Characterizing Departures from Additivity in Multi-Dimensional Drug/Chemical Mixtures." VCU Scholars Compass, 1995. http://scholarscompass.vcu.edu/etd/4507.

Pełny tekst źródła

Streszczenie:

In studies of the effects of multiple drug or chemical combinations, one goal may be to detect and characterize the interactions between the agents. The techniques currently applied to this problem have limitations when the experiments involve more than 2 agents. Certain response-surface techniques require an unrealistic number of observations for studies involving a large number of agents. Current graphical methods are impossible to use in studies of 3 or more agents. In this research two statistical techniques are described that can be applied to studies with an unlimited number of agents. I

Style APA, Harvard, Vancouver, ISO itp.

17

Mao, Di. "A Synthetic Hybrid Molecule for the Selective Removal of Human Pluripotent Stem Cells from Cell Mixtures." Kyoto University, 2017. http://hdl.handle.net/2433/225975.

Pełny tekst źródła

Style APA, Harvard, Vancouver, ISO itp.

18

Phul, Parvinder Singh. "A study into the predictability of the combined effects of mixtures of anticancer drugs." Thesis, University College London (University of London), 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.431083.

Pełny tekst źródła

Style APA, Harvard, Vancouver, ISO itp.

19

Dinge, Aditya. "EUTECTIC MIXTURES OF DRUGS WITH POOR AQUEOUS SOLUBILITY - SOLID STATE CHARACTERIZATION AND DISSOLUTION STUDIES." Diss., Temple University Libraries, 2012. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/196371.

Pełny tekst źródła

Streszczenie:

Pharmaceutical Sciences<br>Ph.D.<br>It is a well reported fact that large number of drugs coming of the drug discovery pipeline show poor aqueous solubility. Eutectic mixture formation of poorly soluble drugs with hydrophilic carriers has been used to enhance the dissolution rate of such poorly soluble drugs. Eutectic mixtures are solid dispersions where the drug and the carrier are both in crystalline form. The eutectic mixture has a lower melting point than either component. Eutectic mixtures are thermodynamically stable systems. The feasibility of developing a dosage form from an eutectic m

Style APA, Harvard, Vancouver, ISO itp.

20

Chevrier, Solène. "Development of subgrid models for a periodic circulating fluidized bed of binary mixture of particles." Phd thesis, Toulouse, INPT, 2017. http://oatao.univ-toulouse.fr/19905/1/CHEVRIER_Solene.pdf.

Pełny tekst źródła

Streszczenie:

Detailed sensitivity numerical studies have shown that the mesh cell-size may have a drastic effect on the modelling of circulating fluidized bed with small particles. Typically, the cell-size must be of the order of few particle diameters to predict accurately the dynamical behaviour of a fluidized bed. Hence, the Euler-Euler numerical simulations of industrial processes are generally performed with grids too coarse to allow the prediction of the local segregation effects. Appropriate modelling, which takes into account the influence of unresolved structures, have been already proposed for mo

Style APA, Harvard, Vancouver, ISO itp.

21

Potter, Catherine. "Application of supercritical fluid technology to the pre-formulation and production of amorphous solid dispersions." Thesis, Queen's University Belfast, 2016. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.677955.

Pełny tekst źródła

Style APA, Harvard, Vancouver, ISO itp.

22

Leifsdotter, Josefine. "Investigation of the micelle-to-vesicle transition in mixtures of an anionic and a cationic surfactant: the effect of adding salt." Thesis, KTH, Skolan för kemivetenskap (CHE), 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-158474.

Pełny tekst źródła

Streszczenie:

Catanoinic systems spontaneously form micelles and vesicles, which are self-assembled spherical structures made up by surfactants. In the core of the micelle a drug, or other organic substance, can be kept to stabilize it when placed in an aqueous environment. The micelle-to-vesicle transition corresponds to the moment when the drug is releases, and understanding which factors that trigger this transition is thus of great interest for the pharmaceutical industry. In this study the micelle-to-vesicle transition in water and the effect of salt were studied for the systems 95 mol% SDS/DDAB and 95

Style APA, Harvard, Vancouver, ISO itp.

23

Vancko, Jr Robert M. "Effect of a drag reducing agent on pressure drop and flow regime transitions in multiphase horizontal low pressure pipelines." Ohio University / OhioLINK, 1997. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1184354301.

Pełny tekst źródła

Style APA, Harvard, Vancouver, ISO itp.

24

Kapote, Dnyaneshwar Nandkumar [Verfasser]. "Improving solubility and supersaturation of poorly soluble drugs using solid dispersions based on natural polymers and mixtures thereof / Dnyaneshwar Nandkumar Kapote." Bonn : Universitäts- und Landesbibliothek Bonn, 2021. http://d-nb.info/1235524434/34.

Pełny tekst źródła

Style APA, Harvard, Vancouver, ISO itp.

25

Gharib, Riham. "Développement du système mixte hydroxypropyl-betacyclodextrine/ liposome en vue de l’encapsulation des constituants des huiles essentielles." Thesis, Lyon, 2016. http://www.theses.fr/2016LYSE1312/document.

Pełny tekst źródła

Streszczenie:

L'objectif principal de notre étude a été la mise au point des formulations liposomiales encapsulant des monoterpènes (MT) et phénylpropènes (PP). Le manuscrit contient deux axes principaux. Le premier a porté sur l'interaction de l'HP-ß-CD, de MT et PP avec des membranes lipidiques. L'HP-ß-CD interagit avec les têtes polaires et les chaînes acyles des phospholipides et montre un effet fluidifiant sur les liposomes formés de DPPC et de Lipoid S100. De plus, l'HP-ß-CD présent dans le compartiment aqueux des liposomes les protège durant la lyophilisation. Les MT et PP interagissent avec la tête

Style APA, Harvard, Vancouver, ISO itp.

26

El, Masri Sarah. "Low transition temperature mixtures based on cyclodextrins as solubilizing vehicles in pharmaceutical preparations." Electronic Thesis or Diss., Littoral, 2024. https://documents.univ-littoral.fr/access/content/group/50b76a52-4e4b-4ade-a198-f84bc4e1bc3c/BULCO/Th%C3%A8ses/Toxicologie/122040_EL_MASRI_2024_archivage.pdf.

Pełny tekst źródła

Streszczenie:

L'amélioration de la solubilité est un aspect critique dans la formulation et le développement de nouvelles molécules thérapeutiques. Pour surmonter les défis associés à une faible solubilité, les chercheurs ont évalué de nombreuses stratégies, dont l'utilisation de cyclodextrines et de cosolvants. Cette dernière approche est une technique simple et efficace, dans laquelle des solvants organiques sont utilisés pour améliorer la solubilité des composés peu solubles dans l'eau. Ces dernières années, les solvants eutectiques profonds (DESs) ont émergé comme une alternative abordable et verte comp

Style APA, Harvard, Vancouver, ISO itp.

27

Castro, João Tiago Duarte Ferreira de. "Benefícios dos estereoisómeros na terapêutica medicamentosa." Master's thesis, [s.n.], 2014. http://hdl.handle.net/10284/4514.

Pełny tekst źródła

Streszczenie:

Projeto de Pós-Graduação/Dissertação apresentado à Universidade Fernando Pessoa como parte dos requisitos para obtenção do grau de Mestre em Ciências Farmacêuticas<br>A maioria dos fármacos comercializados atualmente são estereoisómeros, podendo estes apresentar-se na forma de enantiómeros ou diastereómeros. Desde que ocorreu o desastre da talidomida nos anos 60, a indústria química e farmacêutica apercebeu-se da importância do estudo da quiralidade dos fármacos e das suas propriedades estereoquímicas. A análise da correlação entre a quiralidade e as propriedades toxicológicas e farmacológicas

Style APA, Harvard, Vancouver, ISO itp.

28

DeGagne, Julia Lynn. "Acid-Base Equilibria in Organic-Solvent/Water Mixtures and Their Relevance to Gas/Particle Partitioning in the Atmosphere and in Tobacco Smoke." PDXScholar, 2016. http://pdxscholar.library.pdx.edu/open_access_etds/2733.

Pełny tekst źródła

Streszczenie:

Acid-base equilibria in organic particulate matter (PM) are poorly understood, but have important implications for air quality and public health. First, acid-base reactions in organic particulate matter affect the gas/particle partitioning of organic compounds in the atmosphere, and these processes are not currently represented in atmospheric and climate change models. Second, the acid-base balance of tobacco smoke affects the amount of nicotine absorbed by the smoker, and a greater understanding of this balance would help to relate cigarette smoke composition to the addictive properties of ci

Style APA, Harvard, Vancouver, ISO itp.

29

Ouerdani, Aziz. "Modélisation de données pharmacologiques précliniques et cliniques d'efficacité des médicaments anti-angiogéniques en cancérologie." Thesis, Université Grenoble Alpes (ComUE), 2016. http://www.theses.fr/2016GREAM018/document.

Pełny tekst źródła

Streszczenie:

En l’espace d’une quarantaine d’année, les connaissances sur l’angiogenèse tumorale ont littéralement explosé. Dans les années 1970, Judah Folkman démontre que les tumeurs ont besoin d’être vascularisées pour continuer à proliférer. Peu de temps après, les protagonistes principaux de l’angiogenèse tumorale ont été découverts, de même que les mécanismes dans lesquels ils sont impliqués. La décennie suivante marque le début des recherches sur les molécules à visée anti-angiogénique et c’est en 2004 que le bevacizumab (Avastin, Roche), premier médicament anti-angiogénique utilisé en oncologie, vo

Style APA, Harvard, Vancouver, ISO itp.

30

TOMINAGA, FLAVIO K. "Efeito da irradiação na toxicidade de fármacos em solução aquosa: cloridrato de fluoxetina, diclofenaco de sódio e mistura de ambos." reponame:Repositório Institucional do IPEN, 2016. http://repositorio.ipen.br:8080/xmlui/handle/123456789/26825.

Pełny tekst źródła

Streszczenie:

Submitted by Claudinei Pracidelli (cpracide@ipen.br) on 2016-11-11T16:56:25Z No. of bitstreams: 0<br>Made available in DSpace on 2016-11-11T16:56:25Z (GMT). No. of bitstreams: 0<br>As evidências da contaminação das águas por resíduos de medicamentos e seus subprodutos levou esse grupo de resíduos a compor a lista de poluentes orgânicos emergentes, como consequência da expansão do uso de medicamentos, como o antidepressivo cloridrato de fluoxetina e o anti-inflamatório diclofenaco. Diversos Processos Oxidativos Avançados vêm sendo aplicados para a degradação destes compostos. Dentre eles, o pr

Style APA, Harvard, Vancouver, ISO itp.

31

Pham, Khoa Ngoc. "Conformational Dynamics and Stability Associated with Magnesium or Calcium Binding to DREAM in the Regulation of Interactions between DREAM and DNA or Presenilins." FIU Digital Commons, 2016. http://digitalcommons.fiu.edu/etd/2589.

Pełny tekst źródła

Streszczenie:

Downstream regulatory element antagonist modulator (DREAM) is involved in various interactions with targets both inside and outside of the nucleus. In the cytoplasm, DREAM interacts with the C-terminal fragments of presenilins to facilitate the production of β-amyloid plaques in Alzheimer’s disease. In the nucleus, Ca2+ free DREAM directly binds to specific downstream regulatory elements of prodynorphin/c-fos gene to repress the gene transcription in pain modulation. These interactions are regulated by Ca2+ and/or Mg2+ association at the EF-hands in DREAM. Therefore, understanding the conforma

Style APA, Harvard, Vancouver, ISO itp.

32

Folco-Lognos, Béatrice. "Rôle des pairs dans les trajectoires individuelles d’appropriation psychologique de la maladie : illustration dans le cancer du sein." Thesis, Montpellier 3, 2021. http://www.theses.fr/2021MON30002.

Pełny tekst źródła

Streszczenie:

Etude 1 : Etude exploratoire de l’expérience vécue de patientes expertes appartenant à une association Objectif : Recueillir et analyser les verbatims pour permettre l’émergence de catégories en vue de comprendre le travail de la maladie à travers les interactions avec les Pairs Méthode : Analyse qualitative sémio pragmatique Etude 2 :Interventions non pharmacologiques chez les patientes atteints d'un cancer du sein: une étude exploratoire rétrospective des données des forums de réseaux sociaux. Contexte: Les patients et les professionnels de la santé s'intéressent de plus en plus aux interven

Style APA, Harvard, Vancouver, ISO itp.

33

Brown, Dustin Paul. "TARGET-DIRECTED BIOSYNTHETIC EVOLUTION: REDIRECTING PLANT EVOLUTION TO GENOMICALLY OPTIMIZE A PLANT’S PHARMACOLOGICAL PROFILE." UKnowledge, 2015. http://uknowledge.uky.edu/neurobio_etds/13.

Pełny tekst źródła

Streszczenie:

The dissertation describes a novel method for plant drug discovery based on mutation and selection of plant cells. Despite the industry focus on chemical synthesis, plants remain a source of potent and complex bioactive metabolites. Many of these have evolved as defensive compounds targeted on key proteins in the CNS of herbivorous insects, for example the insect dopamine transporter (DAT). Because of homology with the human DAT protein some of these metabolites have high abuse potential, but others may be valuable in treating drug dependence. This dissertation redirects the evolution of a nat

Style APA, Harvard, Vancouver, ISO itp.

34

Condamine, Ducreux Iris. "Réseaux de sociabilités des personnes utilisant des drogues par injection : expositions, vigilances et protections face aux risques." Electronic Thesis or Diss., Paris, EHESS, 2024. http://www.theses.fr/2024EHES0052.

Pełny tekst źródła

Streszczenie:

En France, parmi les personnes utilisant des drogues par injection, la prévalence du VIH a considérablement diminué au cours des années 2000, mais l'hépatite C reste toujours à un niveau très élevé. Une majorité des nouvelles contaminations par l'hépatite C concerne les personnes utilisant des drogues par injection. De nombreuses études se sont intéressées au partage de matériel d’injection, mais elles se sont souvent centrées, soit sur l’analyse des déterminants du partage, soit sur les processus sociaux en jeu dans ces relations de partage. Rares sont les études qui ont pris en compte la dim

Style APA, Harvard, Vancouver, ISO itp.

35

Haraszti, Reka A. "Engineered Exosomes for Delivery of Therapeutic siRNAs to Neurons." eScholarship@UMMS, 2018. https://escholarship.umassmed.edu/gsbs_diss/971.

Pełny tekst źródła

Streszczenie:

Extracellular vesicles (EVs), exosomes and microvesicles, transfer endogenous RNAs between neurons over short and long distances. We have explored EVs for siRNA delivery to brain. (1) We optimized siRNA chemical modifications and siRNA conjugation to lipids for EV-mediated delivery. (2) We developed a GMP-compatible, scalable method to manufacture active EVs in bulk. (3) We characterized lipid and protein content of EVs in detail. (4) We established how protein and lipid composition relates to siRNA delivering activity of EVs, and we reverse engineered natural exosomes (small EVs) into artific

Style APA, Harvard, Vancouver, ISO itp.

36

Shafi, Shanjeeda. "Machine learning and mixture clustering methods for molecular drug discovery: prediction and characterisation of drugs and druggable targets." Thesis, 2021. http://hdl.handle.net/1959.13/1431097.

Pełny tekst źródła

Streszczenie:

Research Doctorate - Doctor of Philosophy (PhD)<br>In the drug discovery process, approximately five to ten thousand compounds are initially screened but only 1% of these enter the preclinical testing stage that determines whether the compound is safe, efficacious, and feasible to use for a disease state. Owing to regulatory, toxicity, resistance and human health concerns, demand is increasing for refinement of and intensive use of molecular physicochemical properties via effective and robust mathematical methods for drug discovery. Chemoinformatics is now a well-recognised discipline focused

Style APA, Harvard, Vancouver, ISO itp.

37

Wang, Xu. "Statistical Learning in Drug Discovery via Clustering and Mixtures." Thesis, 2007. http://hdl.handle.net/10012/3263.

Pełny tekst źródła

Streszczenie:

In drug discovery, thousands of compounds are assayed to detect activity against a biological target. The goal of drug discovery is to identify compounds that are active against the target (e.g. inhibit a virus). Statistical learning in drug discovery seeks to build a model that uses descriptors characterizing molecular structure to predict biological activity. However, the characteristics of drug discovery data can make it difficult to model the relationship between molecular descriptors and biological activity. Among these characteristics are the rarity of active compounds, the large volume

Style APA, Harvard, Vancouver, ISO itp.

38

"Hepatic arterial embolization with A lipiodol-ethanol mixture in the cirrhotic liver: an experimental trial in an animal model." 2003. http://library.cuhk.edu.hk/record=b5891589.

Pełny tekst źródła

Streszczenie:

Chan Tai-po.<br>Thesis (M.Phil.)--Chinese University of Hong Kong, 2003.<br>Includes bibliographical references (leaves 94-101).<br>Abstracts in English and Chinese.<br>Chapter 1 --- INTRODUCTION --- p.1<br>Chapter 2 --- HYPOTHESIS --- p.3<br>Chapter 3 --- OBJECTIVE --- p.4<br>Chapter 4 --- CLINICAL IMPLICATIONS --- p.5<br>Chapter 5 --- METHODOLOGY --- p.6<br>Chapter 5.1 --- Materials --- p.8<br>Chapter 5.2 --- Study method --- p.13<br>Chapter 5.3 --- Venues of the research --- p.22<br>Chapter 5.4 --- Data acquisition --- p.23<br>Chapter 5.5 --- Data management and analysis --- p.24<

Style APA, Harvard, Vancouver, ISO itp.

39

Mohsenipour, Ali Asghar. "Turbulent Drag Reduction by Polymers, Surfactants and Their Mixtures in Pipeline Flow." Thesis, 2011. http://hdl.handle.net/10012/6393.

Pełny tekst źródła

Streszczenie:

lthough extensive research work has been carried out on the drag reduction behavior of polymers and surfactants alone, little progress has been made on the synergistic effects of combined polymers and surfactants. A number of studies have demonstrated that certain types of polymers and surfactants interact with each other to form surfactant-polymer complexes. The formation of such complexes can cause changes in the solution properties and may result in better drag reduction characteristics as compared with pure additives. A series of drag-reducing surfactants and polymers were screened for th

Style APA, Harvard, Vancouver, ISO itp.

40

Van, Wyk Elzaan. "Determination of the effect of different blade speeds and mixing times on the homogeneity of mixtures containing different ratios of two powders." Thesis, 2015. http://hdl.handle.net/10539/17424.

Pełny tekst źródła

Streszczenie:

A research report submitted to the Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, in partial fulfilment of the requirements for the degree of Master of Science in Medicine in Pharmaceutical Affairs Johannesburg, 2014<br>Aim The first step in a wet granulation process is dry mixing. This step has the objective of ensuring that all the raw materials are mixed such that the end product is homogeneous. Dry mixing in a high shear mixer instead of a blender saves cost. However, the mixing parameters have not been well researched. Dry mixing parameters that are cur

Style APA, Harvard, Vancouver, ISO itp.

41

Huang, Li-Hsiang, and 黃立翔. "Dynamics of Two-Phase Granular Mixture in a Rotating Drum with a Focus on Liquid Effects." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/41373113803356920463.

Pełny tekst źródła

Streszczenie:

碩士<br>臺灣大學<br>機械工程學研究所<br>98<br>This article studies the steady state particle motion in a rotating drum with various interstitial liquids and at different drum speeds. An image analysis routine, that integrates Circular Hough Transformation and particle tracking velocimetry, has been developed to monitor the instantaneous individual particle velocity. Through a spatial and temporal average scheme, the bulk quasi-steady behavior was obtained which consider the collective particle motions as a continuum. The flow properties were investigated, including the solid-volume concentration, bulk veloc

Style APA, Harvard, Vancouver, ISO itp.

42

Hsu, Zong-Ping, and 徐宗平. "Electroporation Enhanced Transdermal Drug Delivery for Melanoma Skin Cancer Therapy by Using DACH-Platinum Conjugated Hyaluronic Acid/Multi-walled Carbon Nanotube Mixtures." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/71692320392112985070.

Pełny tekst źródła

Streszczenie:

碩士<br>國立臺灣大學<br>醫學工程學研究所<br>103<br>Skin cancer is a cancer lesion that Oriental less, but in foreign countries is complicated by high rates of cancer, into basal cell tumor, squamous cell tumors, melanoma. Our experiment is based on the melanoma cells as experimental, mainly because the disease is low, although he was only five percent of skin cancer in the left and right, but because of its high metastatic cause high mortality rate, so we choose in this group were the most experimental groups. Melanoma cells has many first-line drugs, such as Doxorubicin .Oxaliplatin and Cisplatin, etc., amon

Style APA, Harvard, Vancouver, ISO itp.

43

Strickland, Erin Catherine. "Application and Evaluation of a Chemical Modification- and Mass Spectrometry-Based Thermodynamic Assay for the Study of Protein-Ligand Interactions in Complex Mixtures." Diss., 2013. http://hdl.handle.net/10161/7241.

Pełny tekst źródła

Streszczenie:

<p>While a number of different proteomic, genomic, and computational approaches exist for the characterization of drug action, each of the experimental approaches developed to date has both strengths and weaknesses. Currently, there is no one "perfect" assay for drug mode-of-action studies. A protocol that could assay all the proteins in the proteome for both direct and indirect binding interactions of drugs would greatly facilitate studies of drug action. Recently, the SPROX (stability of proteins from rates of oxidation) technique was developed as a chemical modification- and mass spectro

Style APA, Harvard, Vancouver, ISO itp.

44

Koch, Philipp. "Partikelmodellierung der Strukturbildung akustischer Kavitationsblasen in Wechselwirkung mit dem Schalldruckfeld." Doctoral thesis, 2006. http://www.gbv.de/dms/goettingen/524828539.pdf.

Pełny tekst źródła

Style APA, Harvard, Vancouver, ISO itp.

Oferujemy zniżki na wszystkie plany premium dla autorów, których prace zostały uwzględnione w tematycznych zestawieniach literatury. Skontaktuj się z nami, aby uzyskać unikalny kod promocyjny!