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Rozprawy doktorskie na temat „Drug selection”

Autor: Grafiati

Data publikacji: 4 czerwca 2021

Data aktualizacji: 25 lipca 2025

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1

Grice, Christopher Martin. "Peptide aptamer selection for antifungal drug discovery and diagnostics." Thesis, Imperial College London, 2015. http://hdl.handle.net/10044/1/51495.

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The demand for more effective fungal diagnostics and therapeutics is becoming increasingly urgent with increases in incidence of fungal diseases, antifungal resistance and lack of rapid diagnosis resulting in high mortality rates. The research described in this thesis evaluates the Aspergillus fumigatus pH-signalling receptor PalH (which non-redundantly regulates processing of the transcription factor PacC, and is essential for pathogenicity), as a viable therapeutic target. To assess intracellular modulation of PalH functionality, a novel proof-of-principle library of peptide aptamers (PAs),

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Olofsson, Sara K. "Relation Between Drug Exposure and Selection of Antibiotic Resistant Bacteria." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis Univ.-bibl. [distributör], 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-7197.

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Eng, Jeffrey K. L. "Genetic selection by ivermectin on Onchocerca volvulus." Thesis, McGill University, 2006. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=111844.

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Onchocerca volvulus is a parasitic filarial nematode responsible for human onchocerciasis, a disease commonly known as "River Blindness". Although there are no well documented cases of ivermectin resistance in O. volvulus, reports of suboptimal responses to ivermectin have appeared. The purpose of this thesis was to examine genetic polymorphisms in O. volvulus and to determine whether there was genetic evidence of ivermectin selection on O. volvulus genes. Analysis of 17 genes from O. volvulus was undertaken in two populations of worms, either from ivermectin-naive patients or from patients wh

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Larsson, Sonny. "Mistletoes and Thionins : as Selection Models in Natural Products Drug Discovery." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-7705.

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Nilsson, Annika. "Bacterial adaptation to novel selection pressures /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-192-X/.

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Kahatapitiya, Prathibha Chathurani. "Enrichment of skeletal muscle stem cell transplantation using chemotherapeutic drugs." Thesis, The University of Sydney, 2009. http://hdl.handle.net/2123/4050.

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The BCNU + O6benzylguanine (O6BG) driven selective enrichment strategy was first established for enhanced transplantation of hematopoietic stem cells. This study describes a novel application of this BCNU + O6BG driven selective enrichment strategy in skeletal muscle stem cell transplantation. Furthermore, this study addresses the three main limitations observed in previously reported skeletal muscle stem cell transplantation strategies. Limitation of ineffective donor cells which lack the ability for successful engraftment was overcome by using a heterogeneous population of donor cells which

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Kahatapitiya, Prathibha Chathurani. "Enrichment of skeletal muscle stem cell transplantation using chemotherapeutic drugs." University of Sydney, 2009. http://hdl.handle.net/2123/4050.

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Doctor of Philosophy (PhD)<br>The BCNU + O6benzylguanine (O6BG) driven selective enrichment strategy was first established for enhanced transplantation of hematopoietic stem cells. This study describes a novel application of this BCNU + O6BG driven selective enrichment strategy in skeletal muscle stem cell transplantation. Furthermore, this study addresses the three main limitations observed in previously reported skeletal muscle stem cell transplantation strategies. Limitation of ineffective donor cells which lack the ability for successful engraftment was overcome by using a heterogeneous po

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Njoroge, Joyce Muthoni. "Ivermectin selection and characterization of the life history traits of Heligmosomoides polygyrus (Nematoda)." Thesis, McGill University, 1995. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=23417.

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A stock "parent" (S) strain of the mouse parasite Heligmosomoides polygyrus was exposed to increasing levels of ivermectin at the L4 stage for 15 generations. A Passage line was also developed from the parent strain parallel with the ivermectin selected line to control for the effects of rapid passage of the parasite from host to host during drug selection. A dose titration trial indicated 1.5 fold resistance had developed in the ivermectin selected strain at the 8th generation (IVM-8) both at the L4 and adult stage. A higher dose of drug was required to kill the L4 stage compared to the adult

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9

Nalunkuma, Kazibwe Anne J. "Factors influencing the spread and selection of drug resistance in Human African Trypanosomiasis." Thesis, University of Glasgow, 2008. http://theses.gla.ac.uk/381/.

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A growing problem with drug resistance in Human African Trypanosomiasis has necessitated the implementation of screening programmes to monitor for its spread. This thesis describes the study of several factors that can influence the selection and propagation of drug resistance in T. brucei. Human African Trypanosomiasis (HAT) is caused by T. brucei gambiense and T. brucei rhodesiense. The few drugs used for the treatment of the disease are either toxic, cause severe side effects or suffer from parasite resistance. The T. brucei P2 transporter, which is encoded by the gene TbAT1, mediates uptak

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Pulido, Gomez Amalia. "Drug-Related Violence and Party Behavior: The Case of Candidate Selection in Mexico." Thesis, University of North Texas, 2018. https://digital.library.unt.edu/ark:/67531/metadc1248489/.

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This dissertation examines how parties respond and adapt their behavior to political violence. Building a theoretical argument about strategic party behavior and party capture, I address the following questions: How do parties select and recruit their candidates in regions with high levels of violence and the pervasive presence of VNAs? Do parties respond to violence by selecting certain types of candidates who are more capable of fighting these organizations? Do parties react differently at different levels of government? And finally, how do VNSAs capture political selection across at differe

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11

Wang, Guanhua 1970. "Genetic variation in P-glycoprotein in Haemonchus contortus following ivermectin selection." Thesis, McGill University, 2002. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=79203.

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Resistance to ivermectin (IVM) in Haemonchus contortus has developed in many countries and its mechanism is still under investigation. P-glycoproteins (P-gp) are transmembrane proteins that can transport drugs out of cells. Researchers have found that there is polymorphism in a P-gp gene from H. contortus between IVM-selected and unselected worms. Three main P-gp polymorphs were identified, polymorph A was found to be related to IVM selection, while polymorphs B and X were associated with susceptibility. The purpose of this research is to investigate the genetic variations in P-glycopro

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12

Jones, Derek. "Scalable Feature Selection and Extraction with Applications in Kinase Polypharmacology." UKnowledge, 2018. https://uknowledge.uky.edu/cs_etds/65.

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In order to reduce the time associated with and the costs of drug discovery, machine learning is being used to automate much of the work in this process. However the size and complex nature of molecular data makes the application of machine learning especially challenging. Much work must go into the process of engineering features that are then used to train machine learning models, costing considerable amounts of time and requiring the knowledge of domain experts to be most effective. The purpose of this work is to demonstrate data driven approaches to perform the feature selection and extrac

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13

Lochmatter, Priska. "Cytokine selection and CD69 up-regulation in the diagnosis of delayed-type drug hypersensitivity." Bern : [s.n.], 2009. http://www.zb.unibe.ch/download/eldiss/09lochmatter_p.pdf.

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Al-Abbadi, Ibrahim. "Safe, therapeutic and economic pharmaceutical selection (STEPS) as a tool for drug formulary inclusion." Thesis, Queen's University Belfast, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.431400.

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Pugach, Pavel. "The evolutionary response of the HIV-1 ENV complex to selection pressures in vitro /." Access full-text from WCMC:, 2007. http://proquest.umi.com/pqdweb?did=1428842531&sid=4&Fmt=2&clientId=8424&RQT=309&VName=PQD.

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Reynolds, Alan. "Applied evolution : an integrated approach to studying life history traits in response to drug selection." Thesis, University of Glasgow, 2016. http://theses.gla.ac.uk/7673/.

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The use of chemical control measures to reduce the impact of parasite and pest species has frequently resulted in the development of resistance. Thus, resistance management has become a key concern in human and veterinary medicine, and in agricultural production. Although it is known that factors such as gene flow between susceptible and resistant populations, drug type, application methods, and costs of resistance can affect the rate of resistance evolution, less is known about the impacts of density-dependent eco-evolutionary processes that could be altered by drug-induced mortality. The ove

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17

Ragan, Daniel T. "The role of selection effects in the drug-crime relationship a propensity score matching approach /." Tallahassee, Florida : Florida State University, 2009. http://etd.lib.fsu.edu/theses/available/etd-07152009-035659.

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Thesis (M.S.)--Florida State University, 2009.<br>Advisor: Kevin M. Beaver, Florida State University, College of Criminology and Criminal Justice. Title and description from dissertation home page (viewed on Nov. 5, 2009). Document formatted into pages; contains ix, 85 pages. Includes bibliographical references.

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18

Vaidhyanathan, Shruthi. "Selection and Internalization Mechanisms of Targeting Ligands for Invasive Breast Cancer." University of Cincinnati / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1282570605.

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Gallant, Joseph P. "Natural selection and genetic variation in a promising Chagas disease drug target: Trypanosoma cruzi trans-sialidase." ScholarWorks @ UVM, 2017. http://scholarworks.uvm.edu/graddis/807.

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Rational drug design is a powerful method in which new and innovative therapeutics can be designed based on knowledge of the biological target aiming to provide more efficacious and responsible therapeutics. Understanding aspects of the targeted biological agent is important to optimize drug design and preemptively design to slow or avoid drug resistance. Chagas disease, an endemic disease for South and Central America and Mexico is caused by Trypanosoma cruzi, a protozoan parasite known to consist of six separate genetic clusters or DTUs (discrete typing units). Chagas disease therapeutics ar

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20

Feole, Meghan. "Do Safety-related Fields Change Organizational Attractiveness and Job Pursuit Intentions When Drug-testing for Selection?" Thesis, Southern Illinois University at Edwardsville, 2018. http://pqdtopen.proquest.com/#viewpdf?dispub=10685553.

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<p> Drug-testing for employment is still a controversial topic decades after being widely implemented by organizations as experts on both sides of the debate cite ethical and legal concerns among others. The public’s attitudes toward drug-testing, specifically Organizational Attractiveness (OA) and Job Pursuit Intentions (JPI), have predominantly been negative, although when there is a safety element to the job the view towards drug screening is more positive. The aim of this study was to examine if attitudes changed if safety-related jobs were involved. The participants were 106 student

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21

Zhang, Yi. "Application of Hyper-geometric Hypothesis-based Quantication and Markov Blanket Feature Selection Methods to Generate Signals for Adverse Drug Reaction Detection." University of Cincinnati / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1353343669.

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McGregor, Lynn Marie. "Methods for the Identification of Ligand-Target Pairs from Combined Libraries of Targes and Ligands." Thesis, Harvard University, 2014. http://dissertations.umi.com/gsas.harvard:11370.

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Advances in genome and proteome research have led to a dramatic increase in the number of macromolecular targets of interest to the life sciences. A solution-phase method to simultaneously reveal all ligand-target binding pairs from a single solution containing libraries of ligands and targets could significantly increase the efficiency and effectiveness of target-oriented screening efforts. Here, we describe interaction-dependent PCR (IDPCR), a solution-phase method to identify binding partners from combined libraries of small-molecule ligands and targets in a single experiment. Binding betwe

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23

Vradi, Eleni [Verfasser], Werner [Akademischer Betreuer] Brannath, Richardus [Gutachter] Vonk, and Iris [Gutachter] Pigeot. "Biomarker selection and cutoff estimation in drug development / Eleni Vradi ; Gutachter: Richardus Vonk, Iris Pigeot ; Betreuer: Werner Brannath." Bremen : Staats- und Universitätsbibliothek Bremen, 2019. http://d-nb.info/1192909712/34.

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Bendall, Matthew Lewis. "Evaluating the Performance of Computational Approaches for Identifying Critical Sites in Protein-coding DNA Sequences." BYU ScholarsArchive, 2012. https://scholarsarchive.byu.edu/etd/3645.

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The ability to link a particular phenotype to its causative genotype is one of the most challenging objectives for biological research. Although the genetic code provides an explicit formula for determining the sequence of amino acid phenotypes produced by a given nucleotide sequence, identifying specific residues that are functionally important remains problematic. Many computational approaches have been developed that use patterns observed in DNA sequences to identify these critical sites. However, very few research studies have used empirical data to test whether these approaches are truly

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25

Pokomi, Rostand Fankam. "Selection, synthesis and evaluation of novel drug-like compounds from a library of virtual compounds designed from natural products with antiplasmodial activities." University of the Western Cape, 2020. http://hdl.handle.net/11394/7950.

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Magister Pharmaceuticae - MPharm<br>Malaria is an infectious disease which continues to kill more than one million people every year and the African continent accounts for most of the malaria death worldwide. New classes of medicine to combat malaria are urgently needed due to the surge in resistance of the Plasmodium falciparum (the parasite that causes malaria in humans) to existing antimalarial drugs. One approach to circumvent the problem of P. falciparum resistance to antimalarial drugs could be the discovery of novel compounds with unique scaffolds and possibly new mechanisms of action.

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Azizi, Bahareh. "Chemical Complementation: A Genetic Selection System in Yeast for Drug Discovery, Protein Engineering, and for Deciphering and Assembling Biosynthetic Pathways." Diss., Available online, Georgia Institute of Technology, 2005, 2005. http://etd.gatech.edu/theses/available/etd-07182005-102856/.

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Thesis (Ph. D.)--Chemistry and Biochemistry, Georgia Institute of Technology, 2006.<br>Allen M. Orville, Committee Member ; Sheldon W. May, Committee Member ; Jung H. Choi, Committee Member ; Mostafa A. El-Sayed, Committee Member ; Donald F. Doyle, Committee Chair.

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Ruggieri, Francesca. "Putting nature back into drug discovery : selection, design and synthesis of bioinspired chemical libraries for the discovery of new antibacterials." Electronic Thesis or Diss., Université de Lille (2022-....), 2024. http://www.theses.fr/2024ULILS013.

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Les produits naturels (PNs) ont perdu en popularité depuis l'introduction des petites molécules synthétiques il y a plusieurs années. De nombreuses raisons expliquent ce choix, telles que les difficultés d'accès et d'approvisionnement, la complexité de la chimie des PNs et l'avènement de la chimie combinatoire. Cependant, les PNs offrent de nombreuses propriétés intéressantes par rapport aux molécules synthétiques conventionnelles, ce qui leur confère à la fois des avantages et des inconvénients dans le contexte de la recherche de principes actifs. En général, les PNs se caractérisent par un p

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Park, Daniel John. "Evolutionary Adaptation and Antimalarial Resistance in Plasmodium falciparum." Thesis, Harvard University, 2013. http://dissertations.umi.com/gsas.harvard:11088.

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The malaria parasite, Plasmodium falciparum, has a demonstrated history of adaptation to antimalarials and host immune pressure. This ability unraveled global eradication programs fifty years ago and seriously threatens renewed efforts today. Despite the magnitude of the global health problem, little is known about the genetic mechanisms by which the parasite evades control efforts. Population genomic methods provide a new way to identify the mutations and genes responsible for drug resistance and other clinically important traits.

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Ward, Robert Dean. "The role of selection bias in estimates of the deterrence effect of drug testing : evidence from the national longitudinal survey of youth." Thesis, Monterey, Calif. : Springfield, Va. : Naval Postgraduate School ; Available from National Technical Information Service, 1999. http://handle.dtic.mil/100.2/ADA361980.

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Thesis (M.S. in Management) Naval Postgraduate School, March 1999.<br>"March 1999". Thesis advisor(s): Stephen L. Mehay, Rosalie L. Pacula. Includes bibliographical references (p. 81-82). Also available online.

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Buatois, Simon. "Novel pharmacometric methods to improve clinical drug development in progressive diseases." Thesis, Sorbonne Paris Cité, 2018. http://www.theses.fr/2018USPCC133.

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Suite aux progrès techniques et méthodologiques dans le secteur de la modélisation, l’apport de ces approches est désormais reconnu par l’ensemble des acteurs de la recherche clinique et pourrait avoir un rôle clé dans la recherche sur les maladies progressives. Parmi celles-ci les études pharmacométriques (PMX) sont rarement utilisées pour répondre aux hypothèses posées dans le cadre d’études dites de confirmation. Parmi les raisons évoquées, les analyses PMX traditionnelles ignorent l'incertitude associée à la structure du modèle lors de la génération d'inférence statistique. Or, ignorer l’é

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Dudley, Dawn M. "HIV-1 Env impacting HIV-1 fitness, entry inhibitor drug sensitivity, and in vivo selection of a resistant virus to the microbicide PSC-Rantes /." Connect to text online, 2007. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=case1186757280.

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Thesis (Ph. D.)--Case Western Reserve University, 2007.<br>[School of Medicine] Department of Molecular Biology and Microbiology. Includes bibliographical references. Available online via OhioLINK's ETD Center.

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Dudley, Dawn M. "HIV-1 ENV: IMPACTING HIV-1 FITNESS, ENTRY INHIBITOR DRUG SENSITIVITY, AND IN VIVO SELECTION OF A RESISTANT VIRUS TO THE MICROBICIDE PSC-RANTES." Case Western Reserve University School of Graduate Studies / OhioLINK, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=case1186757280.

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Abdouslam, Nouradin Ali. "Impact of pollution on the dissemination of bacterial genes encoding resistance to quaternary ammonium compounds (QACs) and evidence for co-selection of drug resistance genes in environmental bacteria." Thesis, University of Warwick, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.437691.

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Oliveira, Fernando Araújo Rodrigues de. "Estratégias de apoio à captação de estudos clínicos patrocinados." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2018. http://hdl.handle.net/10183/181270.

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Os ensaios clínicos ocorrem cada vez mais em uma escala global e as pesquisas patrocinadas vem mudando para as regiões emergentes. A condução desses estudos traz benefícios para centros de pesquisa, pacientes e para o país como um todo. No entanto, a alocação de ensaios clínicos por companhias farmacêuticas multinacionais é um processo complexo determinado por múltiplos fatores e o conhecimento de quais fatores as companhias farmacêuticas valorizam mais ao alocar ensaios clínicos é escasso. Assim, compreender melhor esse processo é essencial para governos e centros de pesquisa que desejam atra

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Zhu, Jinfei. "Alcohol and illicit substance use in the food service industry assessing self-selection and job-related risk factors /." Columbus, Ohio : Ohio State University, 2008. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1221974238.

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Alayadhi, Nadyah Y. A. H. "Establishing an essential medicine list for the State of Kuwait." Thesis, University of Bradford, 2017. http://hdl.handle.net/10454/15742.

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The Health Sector at the state of Kuwait is facing many challenges. One of which is public expectations in health are high, and thus, the Ministry of Health (MOH) in Kuwait has amplified the health expenditure by 86% since 2007. And since the medicine budget represents half of the total MOH budget, it is proposed that the development in health policy might be a suitable tool to control the inflation within the health budget. This thesis examines the opportunities and challenges of introducing an EML in Kuwait and the factors influencing its effectiveness. A mixed-methodology approach has been

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Kierczak, Marcin. "From Physicochemical Features to Interdependency Networks : A Monte Carlo Approach to Modeling HIV-1 Resistome and Post-translational Modifications." Doctoral thesis, Uppsala universitet, Centrum för bioinformatik, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-109873.

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The availability of new technologies supplied life scientists with large amounts of experimental data. The data sets are large not only in terms of the number of observations, but also in terms of the number of recorded features. One of the aims of modeling is to explain a given phenomenon in possibly the simplest way, hence the need for selection of suitable features. We extended a Monte Carlo-based approach to selecting statistically significant features with discovery of feature interdependencies and used it in modeling sequence-function relationships in proteins. Our approach led to compac

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Dahal, Gopal Prasad. "Development of Selective Inhibitors against Enzymes Involved in the Aspartate Biosynthetic Pathway for Antifungal Drug Development." University of Toledo / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1532889045486984.

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Paterson, Andrew. "Selective catalytic C-H functionalisation for drug discovery." Thesis, University of Bath, 2017. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.720659.

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This thesis details the current methods for meta-selective C-H functionalisation and contains three chapters relating to the area of ruthenium catalysed meta selective functionalisation by σ-activation. The first of which contains a published manuscript entitled “Catalytic meta-selective C-H functionalization to construct quaternary carbon centres” and describes a meta selective tertiary alkylation procedure on 2-phenylpyridine substrates. Key findings from this work provide good evidence for a radical based mechanism and proposes a catalytic cycle involving two distinct roles for the rutheniu

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40

Barrett, Terrance Donald. "Relationship between ischaemia-selective drug action and antiarrhythmic efficacy." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape9/PQDD_0034/NQ38851.pdf.

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Iakovleva, Irina. "Selection of transthyretin amyloid inhibitors." Doctoral thesis, Umeå universitet, Institutionen för medicinsk kemi och biofysik, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-123939.

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Amyloidosis is a group of clinical disorders caused by the aggregation of specific proteins into abnormal extracellular deposits. Today, 31 different proteins have been linked to amyloid diseases including transthyretin-related amyloidosis (ATTR). ATTR occurs through the aggregation of either wild-type plasma protein transthyretin (TTR) or a mutated form. TTR is a homotetramer that under normal circumstances functions as a carrier of thyroxine and retinol binding protein. The aggregation cascade requires dissociation of the tetramer into monomers, and preventing this dissociation represents a

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42

Quader, Sabina, and N/A. "Selective Synthetic Modification of Aminoglycosides for Drug Targeting to Tuberculosis." Griffith University. School of Biomolecular and Physical Sciences, 2007. http://www4.gu.edu.au:8080/adt-root/public/adt-QGU20071024.151619.

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The work presented in this thesis details the synthetic modification of the clinically important aminoglycoside antibiotics, neomycin B, paromomycin and tobramycin. We sought to modify aminoglycosides by attaching lipophilic groups, including fatty acids and steroids, with a view to improving the bacterial membrane permeability of these species, and ultimately their efficacy in the treatment of tuberculosis. Our initial synthetic strategy involved direct and specific functionalization of the singular primary hydroxyl group of the aminoglycoside antibiotic neomycin B, with lipophilic groups co

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Rashid, Badrul Amini Abdul. "Development of selective solid phase extraction sorbents for drug bioanalysis." Thesis, University of Surrey, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.244830.

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Yun, Hannah. "Assessment of ion-selective optical nanosensors for drug screening applications." Thesis, Massachusetts Institute of Technology, 2007. http://hdl.handle.net/1721.1/42129.

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Thesis (M. Eng.)--Massachusetts Institute of Technology, Dept. of Materials Science and Engineering, 2007.<br>"September 2007."<br>Includes bibliographical references (p. 67-69).<br>Ion channels represent an important category of drug targets. They play a significant role in numerous physiological functions, from membrane excitation and signaling to fluid absorption and secretion. An ion-channel assay system using optical nanosensors has recently been developed. This high-throughput, high-content system improves on the existing patch clamp and fluorescent dye technologies that presently domina

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Quader, Sabina. "Selective Synthetic Modification of Aminoglycosides for Drug Targeting to Tuberculosis." Thesis, Griffith University, 2007. http://hdl.handle.net/10072/367086.

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The work presented in this thesis details the synthetic modification of the clinically important aminoglycoside antibiotics, neomycin B, paromomycin and tobramycin. We sought to modify aminoglycosides by attaching lipophilic groups, including fatty acids and steroids, with a view to improving the bacterial membrane permeability of these species, and ultimately their efficacy in the treatment of tuberculosis. Our initial synthetic strategy involved direct and specific functionalization of the singular primary hydroxyl group of the aminoglycoside antibiotic neomycin B, with lipophilic groups co

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Managit, Chittima. "Development of galactosylated liposome and emulsion for hepatocyte-selective drug delivery." 京都大学 (Kyoto University), 2005. http://hdl.handle.net/2433/145203.

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Kok, Robbert Jan. "Targeting of captopril to the kidney: towards selective renal ACE inhibition." [S.l. : [Groningen : s.n.] ; University of Groningen] [Host], 2008. http://irs.ub.rug.nl/ppn/.

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Hamoodi, Nehad Mehdi. "Selective and novel substrates for the assay of neutral glutathione tranferases." Thesis, University of Bradford, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.278924.

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Spann, Melissa Elizabeth Seaman John Weldon. "Bayesian adaptive designs for non-inferiority and dose selection trials." Waco, Tex. : Baylor University, 2006. http://hdl.handle.net/2104/4207.

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Peng, Kevin S. M. Massachusetts Institute of Technology. "An equipment selection methodology for continuous manufacturing of small-molecule drugs." Thesis, Massachusetts Institute of Technology, 2019. https://hdl.handle.net/1721.1/122266.

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This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.<br>Thesis: S.M., Massachusetts Institute of Technology, Department of Chemical Engineering, 2019, In conjunction with the Leaders for Global Operations Program at MIT<br>Thesis: M.B.A., Massachusetts Institute of Technology, Sloan School of Management, 2019, In conjunction with the Leaders for Global Operations Program at MIT<br>Cataloged from student-submitted PDF version of thesis. "June 2019."<br>Includes bibliographical references (pages 87-89).<

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