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Rozprawy doktorskie na temat „Dual inhibitors”

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Data publikacji: 24 sierpnia 2024

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1

Meschini, Elisa. "Purine-based dual inhibitors of CDK2 and CDK7." Thesis, University of Newcastle Upon Tyne, 2011. http://hdl.handle.net/10443/1363.

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Cyclin-Dependent Kinases (CDKs) play a fundamental role in eukaryotic cell cycle progression, particularly at cell cycle checkpoints, and are therefore important targets for anticancer drug discovery. Activation of CDK2 in complex with Cyclin A regulates entry into S phase of the eukaryotic cell cycle. CDK7, a dual-function enzyme, acts both as a CDK-Activating Kinase (CAK) and as a component of the general transcription factor TFIIH. However, experiments with MAT1-knockdown mice have shown that cell cycle arrest by CAK inhibition would not be detrimental for transcriptional activity in non-di
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Green, Ian. "The biology of novel dual histone methyltransferase inhibitors." Thesis, Imperial College London, 2015. http://hdl.handle.net/10044/1/25763.

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Background: EZH2 is a histone methyltransferase (HKMT) responsible for the maintenance of epigenetic silencing of genes through maintenance of the repressive H3K27me3 mark and it is aberrantly regulated in numerous cancers, including breast cancer where it is linked to aggressive phenotypes and poor clinical outcomes. EHMT2 is a related HKMT responsible for gene silencing by mediating H3K9me3 levels. EHMT2 is also responsible for H3K27me1 and has been shown to physically interact with EZH2. Specific inhibitors of EZH2 are available and have been shown to be effective in cancers with EZH2 mutat
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3

Apsel, Beth. "Dual-specificity inhibitors of lipid and protein kinases." Diss., Search in ProQuest Dissertations & Theses. UC Only, 2008. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3311357.

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4

Ren, Baiping. "Molecular Design and Discovery of Single and Dual Inhibitors of Amyloid Peptides." University of Akron / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=akron1555257099229697.

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Wong, Jacky Sui Ki. "The Evaluation of Dual PI3K/mTOR Inhibitors as a Superior Alternative to mTOR Inhibitors in Pre-B Acute Lymphoblastic Leukaemia." Thesis, The University of Sydney, 2014. http://hdl.handle.net/2123/13644.

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Acute lymphoblastic leukaemia (ALL) is the most common form of cancer in children. Poor long term survival in adults as well as the bleak outlook for relapsed patients highlights the need for new therapeutic strategies for the treatment of ALL. The major regulators of ALL cell proliferation and survival mediate their effects through the phosphatidylinositol-3-kinase (PI3K)/mammalian target of rapamycin. It has been previously shown that the mTOR inhibitor RAD001 extended survival in a non-obese diabetic/severe combined immune deficient (NOD/SCID) mouse xenograft model of ALL. The work presente
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Fraser, Sasha. "Development of Dual-Pathway Inhibitors of Raf/MEK/ERK and PI3K/Akt Signaling Pathways." VCU Scholars Compass, 2011. http://scholarscompass.vcu.edu/etd/2619.

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In the present study, we designed a new chemical template that contains an oxindole moiety as potential dual-pathway inhibitors of the Raf/MEK/ERK and PI3K/Akt signaling pathways. The design hypothesis is to evaluate whether the oxindole ring system will approximately orient functional groups in a similar manner to the thiazolidinedione moiety, and thus maintain biological activity as dual-pathway inhibitors of the Raf/MEK/ERK and PI3K/Akt signaling pathways. Furthermore, the oxindole ring will provide the flexibility to allow the introduction of various substituents on the oxindole moiety, th
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7

Steinemann, Gustav [Verfasser]. "Charakterisierung der Wirkmechanismen des neuartigen, dual wirksamen HDAC-Inhibitors „Animacroxam“ am Beispiel testikulärer Keimzelltumore / Gustav Steinemann." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2021. http://d-nb.info/1234984474/34.

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8

Tamhaev, Rasoul. "Conception, synthèse et caractérisation de dérivés diaryl éthers comme nouveaux inhibiteurs directs de la protéine InhA de Mycobacterium tuberculosis." Electronic Thesis or Diss., Université de Toulouse (2023-....), 2024. http://thesesups.ups-tlse.fr/6088/.

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La tuberculose, bien que maladie très ancienne, est toujours une des causes majeures de mortalité due à un agent infectieux unique. En 2021, 10 millions de personnes ont contracté la maladie et 1.5 millions de décès étaient directement imputables à cette dernière. Malgré la disponibilité de toute une panoplie d'antibiotiques, peu d'entre eux s'avèrent efficaces contre l'agent pathogène responsable de la tuberculose, Mycobacterium tuberculosis. Cette inefficacité est principalement due au caractère imperméable de l'enveloppe cellulaire mycobactérienne, composée majoritairement d'acides mycoliqu
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9

Yule, Ian Andrew. "Design, synthesis and biological evaluation of novel, dual targeting inhibitors of bacterial DNA gyrase and topoisomerase IV." Thesis, University of Leeds, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.713881.

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The inevitability of bacterial drug resistance to all marketed antibiotic drug classes warrants continual research into the development of novel chemotype antibacterial agents. Drug resistant `superbugs' such as methicillin resistant Staphylococcus aureus (MRSA) and vancomycin resistant Enterococci (VRE) account for >70% of US hospital bound bacteremias. Such infections are associated with vastly increased rates of morbidity and mortality resulting in a heavy economic burden on health care authorities. The bacterial topoisomerase enzymes DNA gyrase and topoisomerase IV are highly conserved amo
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Foka, Germaine Boulenoue. "Synthesis and evaluation of novel coumarin-donepezil derivatives as dual acting monoamine oxidase B and cholinesterase in Alzheimer's disease." University of the Western Cape, 2016. http://hdl.handle.net/11394/5549.

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Magister Pharmaceuticae - MPharm<br>Alzheimer's disease is a progressive neurodegenerative disease characterised by low acetylcholine (ACh) levels in the hippocampus and cortex of the brain, causing symptoms like progressive memory loss, decline in language skills and other cognitive impairments to occur. The hallmarks of AD include the presence of extracellular insoluble amyloid beta plaques, intracellular neurofibrillary tangles, and the decrease in ACh concentration. The pathophysiology of AD is not well understood, however, acetylcholinesterase (AChE), butyrylcholinesterase (BuChE) and mon
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Potter, Nicola Jane. "Design, synthesis, and biological evaluation of novel dual-target inhibitors of aminoacyl-tRNA synthetases as potential antibacterial agents." Thesis, University of Leeds, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.536093.

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12

Heider, Fabian Andreas [Verfasser]. "Design and synthesis of novel dual GSK3β/p38α MAPK inhibitors and their optimization towards GSK3β selectivity / Fabian Andreas Heider". Tübingen : Universitätsbibliothek Tübingen, 2021. http://d-nb.info/1238594778/34.

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13

Louizos, Connie Celest. "Sexual Inhibition and Sexual Excitation in Erectile Dysfunction." Thesis, The University of Sydney, 2016. http://hdl.handle.net/2123/15843.

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Erectile dysfunction (ED) is a common problem with many aetiologies. The development of phosphodiesterase type 5 inhibitors (PDE5Is) has offered a highly efficacious therapeutic approach to the treatment of ED. However, a significant number of men fail to respond to medication, and others discontinue its use despite good therapeutic responses. Little is known about the determinants of low PDE5I efficacy or compliance. It is recognised that adequate sexual arousal is necessary in order for PDE5Is to have an effect, but arousability is rarely assessed during the routine therapeutic workup. It is
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14

Hamed, Mostafa Mohamed Mostafa [Verfasser], та Rolf W. [Akademischer Betreuer] Hartmann. "Design and synthesis of novel quinazoline-based EGFR kinase inhibitors and dual EGFR/NF-κB inhibitors as potential anti-cancer drugs with enhanced efficacy / Mostafa Mohamed Mostafa Hamed. Betreuer: Rolf W. Hartmann". Saarbrücken : Saarländische Universitäts- und Landesbibliothek, 2013. http://d-nb.info/1078017077/34.

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15

Wang, Danni. "Synthesis and evaluation of antibacterial activity of the dual-action agents : beta-lactamase inhibitors with cytotoxic agents or beta-lactam antibiotics." Thesis, Aston University, 2001. http://publications.aston.ac.uk/12362/.

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16

Schmitt, Christian [Verfasser], and Rolf W. [Akademischer Betreuer] Hartmann. "Development of new lead-like dual inhibitors of the cdc2-like kinase 1 (Clk1) and dual specificity Y-phosphorylation regulated kinases 1A and 1B (Dyrk1A and Dyrk1B) / Christian Schmitt. Betreuer: Rolf W. Hartmann." Saarbrücken : Saarländische Universitäts- und Landesbibliothek, 2014. http://d-nb.info/1056906855/34.

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17

Harmse, Rozanne. "Syntheses of 8-(phenoxymethyl)caffeine analogues and their evaluation as inhibitors of monoamine oxidase and as antagonists of the adenosine A2A receptor / Rozanne Harmse." Thesis, North-West University, 2013. http://hdl.handle.net/10394/9663.

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Background and rationale: Parkinson’s disease (PD) is a progressive, degenerative disorder of the central nervous system and is characterized by the loss of dopaminergic neurons in the substantia nigra pars compacta. The loss of functional dopamine in the striatum is thought to be responsible for the typical symptoms of PD. Cardinal features of PD include bradykinesia, muscular rigidity, resting tremor and impairment of postural balance. This study focuses on the inhibition of monoamine oxidase B (MAO-B) and antagonism of A2A receptors as therapeutic strategies for PD. Monoamine oxidase (MAO)
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Seegers, Julia [Verfasser], and Oliver [Akademischer Betreuer] Werz. "Identification and Characterization of natural products as dual inhibitors of microsomal Prostaglandin E2 Synthase-1 and 5- Lipoxygenase / Julia Seegers ; Betreuer: Oliver Werz." Tübingen : Universitätsbibliothek Tübingen, 2014. http://d-nb.info/1196877912/34.

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Formosa, Márquez Xavier. "Síntesi i avaluació farmacològica d'inhibidors de l'acetilcolinesterasa de lloc d'unió dual com a potencials fàrmacs anti-Alzheimer i estudis relacionats." Doctoral thesis, Universitat de Barcelona, 2006. http://hdl.handle.net/10803/671014.

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Se ha llevado a cabo la síntesis y evaluación farmacológica de dos nuevas familias de inhibidores de acetilcolinesterasa de sitio de unión dual, los heterodímeros huprina-tacrina y los heterodímeros donepezilo-tacrina. Los ensayos farmacológicos han puesto de manifiesto que estos compuestos poseen una afinidad y potencia inhibidora extraordinariamente aumentadas respecto a los compuestos modelo, hecho que los presenta como interesantes candidatos a fármacos anti-Alzheimer. Paralelamente, como consecuencia de unos resultados inesperados obtenidos en el contexto de la síntesis de los heterodí
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20

Nörz, Dominik Sebastian [Verfasser], and Manfred [Akademischer Betreuer] Jücker. "Dual Inhibition of PI3K-AKT-mTOR- and RAF-MEK-ERK signaling is synergistic in cholangiocarcinoma and reverses acquired resistance to MEK-Inhibitors / Dominik Sebastian Nörz. Betreuer: Manfred Jücker." Hamburg : Staats- und Universitätsbibliothek Hamburg, 2016. http://d-nb.info/1093411325/34.

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Mohamad, Taib Mohamad Nurul Azmi. "Isolation and identification of cyclic polyketides from endiandra kingiana gamble (lauraceae), as bcl-xl/bak and mcl-1/bid dual inhibitors, and approaches toward the synthesis of kingianins." Palaiseau, Ecole polytechnique, 2015. https://tel.archives-ouvertes.fr/tel-01260359/document.

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Un criblage biologique préliminaire a montré que l'extrait des écorces d'Endiandrakingianapossédait une forte affinité pour la protéine anti-apoptotique Bcl-xL, motivant ainsi la réalisationd’une étude chimique complète. Deux groupes de composés ont été isolés et caractérisés: d’une part, huit nouveaux dérivés de l'acide endiandrique (les acides kingianiques A à H [120−127]) et d’autre part, trois nouvelleskingianines (les kingianines O à Q [128−130]). Le potentiel inhibiteur des nouvelles molécules vis-à-vis des interactionsBcl-xL/Bak et Mcl-1/Bida ensuite été évalué, ainsi que leurs propriét
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Abdelrahim, Mohamed Salah Rezk [Verfasser]. "Development of the first dual inhibitors for steroid sulfatase (STS) and 17β-hydroxysteroid dehydrogenase type 1 (17β-HSD1) : a novel treatment approach for endometriosis / Mohamed Salah Rezk Abdelrahim". Saarbrücken : Saarländische Universitäts- und Landesbibliothek, 2019. http://d-nb.info/1236897048/34.

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VALLONE, ALESSANDRA. "INVESTIGATION OF NOVEL THERAPEUTIC TOOLS AGAINST INFECTIOUS DISEASES Part 1. Medicinal Chemistry Investigation of MMV019918 Derivatives as Dual Schizonticide And Gametocytocidal Agents Against Plasmodium falciparum Part 2. Investigation of 5-Aryl-Heterocycles As Potential Inhibitors of Metallo beta-Lactamase Enzymes." Doctoral thesis, Università di Siena, 2017. http://hdl.handle.net/11365/1004943.

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Among infectious diseases, two large groups have great clinical relevance: parasitic and bacterial infections. Belonging to the first category is malaria, caused by the parasite Plasmodium falciparum. Transmission of Plasmodium parasites between humans and Anopheles mosquitoes is one of the most important contributors to the global impact of malaria and to the difficulties encountered in eliminating this parasite1 . Gametocytogenesis, the process by which merozoites switch from asexual replication to produce male and female gametocytes, represents a critical step in malaria transmission
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Christofakis, Steven. "SCRIBBLE: A POTENTIAL DUAL KINASE INHIBITOR." VCU Scholars Compass, 2010. http://scholarscompass.vcu.edu/etd/72.

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Extracellular signal-regulated kinases (ERKs) modulate cellular activities in response to extracellular stimuli and play important biological roles. Thus, perturbed kinase pathways induce pathological conditions, such as tumor development. Rit, a novel member of the Ras family GTPases, activase ERK6, and its over-expression confers tumorigenicity. We hypothesized the presence of scaffolding molecules specific to ERK6, similar to other known MAP kinases. We performed yeast two-hybrid assays using ERK6 as bait, and Scribble was identified as a binding partner. Scribble contains 16 LRR domai
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Venkateswaran, Rashmi. "The dual nature of carbon: Catalyst and inhibitor." Thesis, University of Ottawa (Canada), 1994. http://hdl.handle.net/10393/9910.

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The goal of this project was to study the reactivity of thin pyrolitic carbon films on quartz, formed from propylene, methane and butadiene, using the methane conversion reaction as a test. The reactivity was compared to that of quartz. The rate of dissociation of methane on the carbon surface was as much as forty times greater than on quartz. The actual rate increase depended on the precursor of the carbon film. When the reproducibility of the carbon films was tested, the rate was observed to decrease with consecutive experiments. Subsequent analysis showed that small amounts of carbon were d
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Copin, Chloé. "Exploration moléculaire en série imidazo[2, 1-b][1, 3, 4]thiadiazole : applications à la synthèse d'inhibiteurs de kinases impliqués dans les maladies neurodégénératives." Thesis, Orléans, 2013. http://www.theses.fr/2013ORLE2074.

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Depuis plus d’un siècle, la chimie hétérocyclique représente l’un des plus vastes domaines de recherche en chimie organique. En particulier, les hétérocycles bicycliques fusionnés à 5 chaînons, contenant à la fois des atomes de soufre et d’azote, présentent, de par leur rareté et leur potentiel biologique, un champ d’intérêt croissant pour les équipes de recherche et développement académiques ou des entreprises pharmaceutiques. Parmi les nombreux composés bicycliques [5-5], notre étude s’est focalisée sur le noyau imidazo[2,1-b][1,3,4]thiadiazole décrit sporadiquement dans la littérature et po
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Hall, Drew Anthony. "Investigating the structure and binding mechanism of QseM, a novel dual-target protein-inhibitor." Thesis, Curtin University, 2021. http://hdl.handle.net/20.500.11937/87895.

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This thesis details the structural characterisation of a novel protein, QseM, through the use of X-ray crystallography and nuclear magnetic resonance. QseM contains the uncharacterised DUF2285 domain, which, through this work, has been revealed to be a novel helix-turn-helix motif.
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Ströbele, Stephanie [Verfasser]. "Glioblastoma : the effects of the dual kinase inhibitor PI-103 on glioblastoma cells / Stephanie Ströbele." Ulm : Universität Ulm, 2020. http://d-nb.info/121518851X/34.

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CAMPANER, ELENA. "A new covalent PIN1 inhibitor selectively targets cancer cells by a dual mechanism of action." Doctoral thesis, Università degli Studi di Trieste, 2017. http://hdl.handle.net/11368/2908180.

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In the last decades targeted drugs have improved cancer treatment, but revealed to be ineffective mainly in the treatment of solid tumors, largely because of tumor heterogeneity, activation of redundant pathways, and drug resistance. A common and central signal transduction mechanism in many oncogenic pathways is the phosphorylation of proteins at serine or threonine residues followed by proline (S/T-P). Importantly, the phospho-S/T-P motifs of these proteins are recognized by the peptidyl-prolyl cis/trans isomerase (PPIase) PIN1, which catalyzes the cis-trans or trans-cis conformational chang
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Leary, Alexandra. "Laboratory and clinical studies of the dual EGFR/HER2 tyrosine kinase inhibitor lapatinib in breast cancer." Thesis, Institute of Cancer Research (University Of London), 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.538329.

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Morooka, Satoshi. "Identification of a Dual Inhibitor of SRPK1 and CK2 that Attenuates Pathological Angiogenesis of Macular Degeneration in Mice." Kyoto University, 2015. http://hdl.handle.net/2433/202798.

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Miguel, Mariana Cardoso. "Produção recombinante e caracterização de duas cistatinas de cana-de-açúcar." Universidade Federal de São Carlos, 2014. https://repositorio.ufscar.br/handle/ufscar/5553.

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Made available in DSpace on 2016-06-02T20:21:37Z (GMT). No. of bitstreams: 1 6416.pdf: 7607633 bytes, checksum: e01f0f58b2ee5032346c3d9eae67f4ac (MD5) Previous issue date: 2014-09-05<br>Financiadora de Estudos e Projetos<br>Cystatins are reversible inhibitors of cysteine peptidases. The cystatins found in plants are called phytocystatins, and represent an independent subfamily of the cystatins superfamily. Some studies have reported significant pleiotropic effects for recombinant cystatins expressed in transgenic plants, notably including tolerance phenotypes against attack of herbivorous ar
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ZUCCOLO, MARCO. "NEW APPROACHES IN THE DISCOVERY OF NATURAL PRODUCT-BASED AGROCHEMICALS." Doctoral thesis, Università degli Studi di Milano, 2018. http://hdl.handle.net/2434/606602.

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Currently, the increase of food demand of a steadily growing human population is not balanced by a global agricultural supply. As a consequence, crop protection plays a crucial role in maximising crop productivity and preventing losses caused by biological and not biological agents. Biological agents, collectively named as pests, are responsible for quantitative losses ranging from 20 % to 40 %, and qualitative losses, thus reducing the value of crops. For these reasons, new methods to control pests must be developed.The discovery of new agrochemicals is necessary to face the problem of the em
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Starok, Marcelina Anna. "EGFR inhibition by curcumin in cancer cells : a dual mode of action." Thesis, Compiègne, 2014. http://www.theses.fr/2014COMP2093.

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Le récepteur de facteur de croissance épidermique (EGFR) est une cible commune de thérapie anticancéreuse. Aujourd'hui, la recherche de nouvelles molécules inhibitrices de ce récepteur se tourne vers des substances naturelles. Un des composés naturels les plus prometteurs qui ont montré une activité anti-EGFR est la curcumine, un polyphénol présent dans les rhizomes de Curcuma longa. Il y a de nombreux rapports décrivant son effet sur l'activité kinase du récepteur, le rendement d'autophosphorylation, le niveau d'expression et les processus liés à la fonction EGFR comme la prolifération cellul
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Guéret, Pierre. "Développement clinique de l'EP217609 et de son antidote l'avidine." Thesis, Brest, 2017. http://www.theses.fr/2017BRES0130.

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Les pentasaccharides sont des inhibiteurs indirects du facteur Xa ayant des profils pharmacocinétiques très prédictibles. En raison de la liaison de forte affinité des pentasaccharides à l'antithrombine, cette pharmacocinétique peut être prédite mais aussi transférée à d'autres molécules qui leur sont liées de manière covalente. L'EP42675 combine dans une seule molécule, une antithrombine directe réversible peptidomimétique (analogue de l'α-NAPAP), et un pentasaccharide inhibiteur indirect du facteur Xa antithrombine dépendant (analogue du fondaparinux). L'EP217609 est le dérivé biotinylé de l
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Bendjeddou, Lyamin. "Synthèse et évaluation biologique de nouveaux inhibiteurs de kinases : identification d‘inhibiteurs de kinases parasitaires." Thesis, Paris 5, 2014. http://www.theses.fr/2014PA05P615.

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La phosphorylation des protéines par les kinases est l’une plus importantes modification post-traductionnelle dans les processus cellulaires tels que la division, la différenciation, la prolifération et l’apoptose. Due à leur rôle clef, un dérèglement des protéines kinases peut entrainer de nombreuses pathologies proliférative telles que le cancer et non prolifératives telles que les maladies neurodégénératives. Le travail de thèse s’est construit autour de 2 séries d’inhibiteurs de protéine kinases comportant les noyaux imidazo[1,2-b]pyridazine et imidazo[4,5-b]pyridine. L’objectif est d’inhi
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Schweppenhäuser, Johannes. "Selektive und duale COX-1-COX-2-Inhibitoren aus der Reihe der Methanone Synthese, Testung, Struktur-Wirkungs-Beziehungen /." [S.l.] : [s.n.], 1999. http://deposit.ddb.de/cgi-bin/dokserv?idn=960235728.

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Eyermann, Barbara [Verfasser], Stephan A. [Akademischer Betreuer] Sieber, Wolfgang [Gutachter] Eisenreich, and Stephan A. [Gutachter] Sieber. "A Dual Inhibitor Attenuates Biofilm Formation and Virulence in Staphylococcus aureus and Manipulation of ClpP Activity / Barbara Eyermann ; Gutachter: Wolfgang Eisenreich, Stephan A. Sieber ; Betreuer: Stephan A. Sieber." München : Universitätsbibliothek der TU München, 2019. http://d-nb.info/1201482755/34.

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Rennó, André Lisboa 1984. "Efeitos de duas estatinas sobre células-tronco neoplásicas em modelo murino de carcinogênese mamária por indução química." [s.n.], 2014. http://repositorio.unicamp.br/jspui/handle/REPOSIP/312485.

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Orientador: André Almeida Schenka<br>Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas<br>Made available in DSpace on 2018-08-25T22:24:18Z (GMT). No. of bitstreams: 1 Renno_AndreLisboa_D.pdf: 23208237 bytes, checksum: c782ca447d3fee7cb5573e4b122b7f94 (MD5) Previous issue date: 2014<br>Resumo: O câncer mamário é a neoplasia maligna mais incidente e a principal causa de óbito por malignidade no sexo feminino no Brasil e no mundo. Estipula-se que há mais de 1.2 milhões de novos casos anuais de câncer de mama, e que a heterogeneidade e a complexidade molecular d
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Yokota, Asumi. "INNO-406, a novel BCR-ABL/Lyn dual tyrosine kinase inhibitor, suppresses the growth of Ph[+] leukemia cells in the central nervous system, and cyclosporine A augments its in vivo activity." Kyoto University, 2009. http://hdl.handle.net/2433/126449.

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Kyoto University (京都大学)<br>0048<br>新制・課程博士<br>博士(医学)<br>甲第14902号<br>医博第3387号<br>新制||医||977(附属図書館)<br>27340<br>UT51-2009-M816<br>京都大学大学院医学研究科医学専攻<br>(主査)教授 武藤 誠, 教授 武田 俊一, 教授 松岡 雅雄, 教授 戸井 雅和<br>学位規則第4条第1項該当
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Moraes, Bibiana Silveira. "Alterações fisiológicas e morfológicas de duas cultivares de arroz irrigado após aplicação do herbicida imazamox na fase reprodutiva." Universidade Federal de Santa Maria, 2013. http://repositorio.ufsm.br/handle/1/3216.

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior<br>Weed control is one of the main agricultural practices indispensable to ensure profitability and crop success. In paddy rice field, red rice is the most important weed due to its difficult control. A widespread control method is the use of rice cultivars resistant to herbicides which are inhibitors of ALS, since it is possible to have a selective chemical control. Studies showed that the late control with imazamox promotes efficient control of red rice escapes. Thus, the objective of this research was to check the effects of i
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Wang, Qinzhe. "Developing Approaches to Treat Canavan Disease." University of Toledo / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1493301078219765.

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Geny, Charlotte. "Recherche d'inhibiteurs naturels des protéines anti-apoptotiques Bcl-xL et Mcl-1." Thesis, Paris 11, 2014. http://www.theses.fr/2014PA114833/document.

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Dans le but de rechercher des inhibiteurs naturels des protéines anti-Apoptotiques Bcl-XL et Mcl-1, deux essais biologiques ont été mis au point sur Bcl-XL/Bak-CF et Mcl-1/Bid-CF. Ces deux tests utilisent la polarisation de fluorescence et sont basés sur la liaison d’un peptide pro-Apoptotique marqué à la fluorescéine (Bak-CF ou Bid-CF) avec une protéine anti-Apoptotique (Bcl-XL ou Mcl-1). Au total, près de 600 extraits de pantes, provenant de diverses régions du monde, ont été criblés sur les deux protéines Bcl-XL et Mcl-1 permettant de sélectionner les extraits acétate d’éthyle des écorces d
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Huang, Hung-Jin, and 黃泓縉. "Virtual screening and drug design for H1N1 dual-target inhibitors." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/70524014777917613113.

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碩士<br>中國醫藥大學<br>生物科技學系碩士班<br>98<br>Influenza viruses contain two major surface glycoproteins, hemagglutinin and neuraminidase, which are therapeutic targets for inhibiting influenza viruses from infecting host cell. Pandemic of H1N1/09 virus has been reported, and drug resistance was regarded as an important issue since 2009. Thus, the purpose of this research is to design novel potent dual inhibitors for the two surface glycoproteins on H1N1 virus. In this study, structure-based and ligand-based drug designs were performed to analyze interactions between target proteins and ligands, and molec
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Kuo, Chia-Chen, and 郭家珍. "Discovery of dual target inhibitors for Alzheimer's disease by virtual screening." Thesis, 2017. http://ndltd.ncl.edu.tw/handle/7269ab.

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碩士<br>國立東華大學<br>生命科學系<br>105<br>The most common type of dementia is Alzheimer's disease (AD), which makes up 60% to 70% of cases. Globally, dementia affects 47 million people. Patients will have cognitive and memory function of brain degeneration symptoms. Acetylcholine (ACh) is the neurotransmitter used at the Central Nervous System (CNS). Pharmacological treatment of AD is based on the use of acetylcholinesterase inhibitors, which have beneficial effects on cognitive, functional, and behavioural symptoms of the disease. Two types of ACh enzyme are found in the CNS, acetylcholinesterase (AChE
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Capitosti, Scott Michael. "Thalidomide analogues : dual inhibitors of both angiogenesis and human cancer cell proliferation /." 2004. http://wwwlib.umi.com/dissertations/fullcit/3144655.

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Elsinghorst, Paul Wilhelm [Verfasser]. "Dual-mode cholinesterase inhibitors targeting muscarinic receptors / vorgelegt von Paul Wilhelm Elsinghorst." 2007. http://d-nb.info/983086427/34.

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Kuo, Po-Hsien, and 郭柏賢. "The Developments of Dual EGFR and c-Met Kinase Inhibitors and DBPR104 Phosphate Prodrugs." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/eg23ma.

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Sola, I., S. Castellà, E. Viayna, et al. "Synthesis, biological profiling and mechanistic studies of 4-aminoquinoline-based heterodimeric compounds with dual trypanocidal–antiplasmodial activity." 2015. http://hdl.handle.net/10454/7485.

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Yes<br>Dual submicromolar trypanocidal–antiplasmodial compounds have been identified by screening and chemical synthesis of 4-aminoquinoline-based heterodimeric compounds of three different structural classes. In Trypanosoma brucei, inhibition of the enzyme trypanothione reductase seems to be involved in the potent trypanocidal activity of these heterodimers, although it is probably not the main biological target. Regarding antiplasmodial activity, the heterodimers seem to share the mode of action of the antimalarial drug chloroquine, which involves inhibition of the haem detoxification proces
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Yo-HuaLi and 李祐華. "Targeting Dual-Specificity Phosphatase-2 by Novel Histone Deacetylase Inhibitors as a Cancer Therapeutic Strategy." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/x9a783.

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