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Rozprawy doktorskie na temat „Endocrine resistance”

Autor: Grafiati

Data publikacji: 4 czerwca 2021

Data aktualizacji: 25 lipca 2025

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1

Tewari, Nilanjana. "Mechanisms underlying obesity-related insulin resistance." Thesis, University of Nottingham, 2016. http://eprints.nottingham.ac.uk/34081/.

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This thesis investigates the effect of body composition on insulin resistance and the impact of supplementation with nutritional support or carbohydrate treatment. Insulin resistance occurs as a response to a number of stressors, including surgery. However, the mechanism underlying the development of insulin resistance is as yet unclear. Adipose tissue distribution appears to play a role in the development of insulin resistance and obesity-related complications. In obese and non-obese patients undergoing open abdominal surgery who received preoperative carbohydrate or placebo, there was a sign

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Ertefai, Benyamin. "Resistance mechanisms during endocrine treatment in breast cancer." Thesis, Cardiff University, 2016. http://orca.cf.ac.uk/95393/.

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Prolonged endocrine therapy is the mainstay of treatment for ER+ breast cancer patients. However, resistance develops in many patients which leads to more aggressive disease. Understanding the mechanisms of acquired resistance that emerge as a consequence of prolonged endocrine treatment remains critical. This study aimed to use gene expression profiling to discover induced mechanisms shared by a panel of MCF7-derived acquired resistant cells that underpin endocrine resistant growth. The in vitro panel represents resistance to oestrogen deprivation, tamoxifen or fulvestrant and includes long-t

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McNeil, Catriona Mairi Garvan Institute of Medical Research Faculty of Medicine UNSW. "Downstream targets of the oestrogen receptor and endocrine resistance." Publisher:University of New South Wales. Garvan Institute of Medical Research, 2008. http://handle.unsw.edu.au/1959.4/41025.

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The transcription factor c-Myc is an early downstream target of oestrogen action in breast cancer cells in culture and it has been speculated that aberrant c-Myc expression may mediate antioestrogen resistance. However, studies of c-Myc protein expression as either a prognostic or predictive marker in human breast cancer have been limited and contradictory, as have been studies of c-Myc expression during breast cancer evolution. In order to assess the relationship between c-Myc protein expression and outcome from breast cancer, a representative cohort of 292 women with invasive ductal carcinom

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Moore, Kate. "Collateral resistance to oestrogen and erbB receptor activated growth in endocrine resistant breast cancer." Thesis, University of Edinburgh, 2007. http://hdl.handle.net/1842/24993.

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A panel of breast cancer cell lines (MIII, LCC1, LCC2, LCC9, LY2) derived from the MCF-7 breast cancer cell line with varying oestrogen and anti-oestrogen insensitivity (termed ‘resistant’) was used as a model to determine signalling pathways which may contribute to the development of this insensitivity. 17β-oestradiol (E<sub>2</sub>) only significantly stimulated growth in MCF-7, MIII and LCC1 cell lines. Resistant cells were insensitive to growth factors, while MCF-7 cells remained responsive. MIII and LCC1 cells retained some tamoxifen sensitivity, while the remaining cell lines were unaffe

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Burmi, Rajpal Singh. "Identification of genes associated with endocrine resistance in breast cancer." Thesis, Cardiff University, 2006. http://orca.cf.ac.uk/55621/.

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Resistance to tamoxifen, Faslodex and oestrogen-deprivation represents a major hurdle in breast cancer management, and determining the underlying factors driving resistant growth may improve treatment and prognosis. Expression microarrays (Atlas Plastic Human 12K Microarrays GeneSifter software) were used to identify genes altered in breast cancer models with acquired resistance to tamoxifen (TamR) or Faslodex (FasR) versus their parental MCF-7 cell line through cluster analysis, t-testing and ontological examination. Selected genes were verified by PCR, Western blotting and immunocytochemistr

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6

Wallace, I. R. "The influence of dietary and endocrine factors on insulin resistance." Thesis, Queen's University Belfast, 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.677846.

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Insulin resistance is a characteristic feature of type 2 diabetes mellitus (DM ) and is associated with increased cardiovascular disease. This thesis presents one randomised controlled trial and two cross-sectional analyses, examining the influence of fruit and vegetable consumption and endocrine factors (se~ hormone binding globulin and vitamin D) on insulin resistance. After a 4 week diet of 1-2 portions fruit and vegetables per day, 105 overweight (8MI 27 - 35kg/m2), nondiabetic subjects at elevated cardiovascular disease risk (>20% 1 O-year CVD risk), were randomised to follow a diet of 1-

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7

Chen, Chun. "Systems Biology Study of Breast Cancer Endocrine Response and Resistance." Diss., Virginia Tech, 2013. http://hdl.handle.net/10919/51965.

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As a robust system, cells can wisely choose and switch between different signaling programs according to their differentiation stages and external environments. Cancer cells can hijack this plasticity to develop drug resistance. For example, breast cancers that are initially responsive to endocrine therapy often develop resistance robustly. This process is dynamically controlled by interactions of genes, proteins, RNAs and environmental factors at multiple scales. The complexity of this network cannot be understood by studying individual components in the cell. Systems biology focuses on the i

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Atefi, Mohammad Sadegh. "Estrogen receptor signaling and mechanism of resistance to endocrine therapy." Diss., Restricted to subscribing institutions, 2008. http://proquest.umi.com/pqdweb?did=1581647181&sid=19&Fmt=2&clientId=1564&RQT=309&VName=PQD.

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Bokhari, Ali, Sathvika Gaddam, and Deepika 7471363 Nallala. "A Case of Compensated Thyroid Hormone Resistance." Digital Commons @ East Tennessee State University, 2019. https://dc.etsu.edu/asrf/2019/schedule/50.

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INTRODUCTION Impaired sensitivity to thyroid hormone is described as any process that interferes with the effectiveness of thyroid hormone and includes defects in thyroid hormone action, transport, or metabolism. Here we present a case of a 60-year-old man with resistance to thyroid hormone (RTH), the most common form of impaired sensitivity. CASE A 60-year-old male presented to the endocrinology clinic with complaints of fatigue, decreased concentration, and impaired memory. He denied neck swelling, neck pain, peripheral edema, or any significant changes in weight, temperature sensitivity, bo

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Sadler, Amanda J. "Identification of novel genes associated with endocrine resistance in breast cancer." Thesis, University of Reading, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.485503.

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The overall aims of this project were to identify rnRNAs overexpressed or underexpressed as MCF7 human breast cancer cells progress to growth pathways independent of oestrogen and resistant to the antioestrogen, fulvestrant. Growth of oestrogen maintained and long-term oestrogen deprived MCF7,cells with or without la-8M l7p-oestradiol for 7 days enabled the comparison of expression profiles to identify a number of oestrogen regulated genes, in addition to a number of genes differentially expressed in long-term oestrogen deprived cells compared to cells which had been deprived of oestrogen for

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11

Boone, Carleigh. "Endocrine and Contralateral Muscle Responses to Short-term Unilateral Resistance Training." Master's thesis, University of Central Florida, 2014. http://digital.library.ucf.edu/cdm/ref/collection/ETD/id/6248.

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PURPOSE: The purpose of this study was to examine the effects of short-term lower body unilateral resistance training on hormonal, muscle morphological, and performance measures in young men. METHODS: Seventeen healthy, untrained young men (Age: 22.8 ± 3.7 y; BMI: 26.5 ± 4.9 kg/m2) were randomly assigned to one of two groups (UT: 22.9 ± 4.6 y, 25.3 ± 4.2 kg/m2; CON: 24.0 ± 4.6 y, 27.7 ± 5.1 kg/m2). Resistance training consisted of 4 weeks of unilateral lower body and bilateral upper body exercises on 3 days per week. Each training session entailed unilateral countermovement jumps (3 ± 8), uni

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12

Al-Naser, Al Zekri Huda M. "Oligo/amenorrhoea : endocrine profiles, ovarian ultrasound, insulin resistan and anthropometric factors; relationships between insulin resistance and ovarian function." Thesis, University of Glasgow, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.360284.

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Ray, Swagat. "Growth Factor Pathways in Development of Endocrine Resistance in Human Breast Cancer Cells." Thesis, University of Reading, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.520093.

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Shaw, Lesley E. "The identification of novel genes associated with endocrine resistance in human breast cancer." Thesis, University of Reading, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.408985.

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15

Chae, Sungwon. "Acute Endocrine Responses to Rest Redistribution with Heavier Loads in Resistance-Trained Men." Thesis, University of North Texas, 2020. https://digital.library.unt.edu/ark:/67531/metadc1707275/.

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The purpose of this study was to investigate endocrine responses to redistribution with heavier loads (RR+L) during back squat (BS) exercise in resistance-trained men. Ten men (mean±SE; 23±2 years, 175.6±2.0 cm, 78.0±3.4 kg, 4±1 training years) were assigned using randomization to either RR+L (4 sets of (2×5 repetitions) of BS with 30 s intra-set and 90 s inter-set rest using 75% of their 1RM) or traditional sets (TS; 4 sets of 10 repetitions of BS with 120 s inter-set rest using 70% of their 1RM). Fasted blood samples were collected pre-exercise (PRE), immediately post-exercise (IP), and 5 (+

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16

Simões, Joana Filipe Marques. "Regulation of estrogen receptor interactome in acquisition of endocrine resistance in breast cancer." Master's thesis, Universidade de Aveiro, 2014. http://hdl.handle.net/10773/14919.

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Mestrado em Bioquímica - Bioquímica Clínica<br>Breast cancer is a multifactorial disease which remains the main cause of cancer in women. Approximately 70% of all breast cancers diagnosed are estrogen receptor (ER) positive and therefore ERα remains the primary target for endocrine therapies. Currently, tamoxifen (Tam) is the most successful targeted antiestrogen treatment, although the acquisition of Tam resistance have been associated with high rates of Tam relapse and also its ineffectiveness as a first line treatment in breast cancer. The ER interactome has been associated with the modula

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17

Sofyali, Emre [Verfasser], and Stefan [Akademischer Betreuer] Wiemann. "GLYATL1 PROMOTES ENDOCRINE THERAPY RESISTANCE IN BREAST CANCER / Emre Sofyali ; Betreuer: Stefan Wiemann." Heidelberg : Universitätsbibliothek Heidelberg, 2020. http://d-nb.info/1218785217/34.

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Arthur, Laura Margaret. "Tumour evolution over time : treatment and progression : exploring the molecular heterogeneity of oestrogen receptor positive breast cancer." Thesis, University of Edinburgh, 2017. http://hdl.handle.net/1842/29581.

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Introduction Recent advances in microarray technology have allowed more understanding of the complex molecular biology of breast cancer. The traditional prognostic information afforded by hormone receptor status and pathology variables is being supplemented and superseded by gene signatures predictive of risk of recurrence and response to treatments. Approximately 75% of breast cancers are oestrogen receptor positive (ER+) and can be treated by drugs that block oestrogen production such as letrozole. However not all ER+ tumours respond and even those that initially respond can develop resistan

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Cerqueira, Vera. "Role of intracellular signalling pathways in conferring resistance to endocrine therapies in breast cancer." Thesis, University of Edinburgh, 2010. http://hdl.handle.net/1842/4511.

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Breast cancer is the most prevalent form of cancer in women and accounts for 519,000 annual deaths (WHO Statistics). It has long been established that oestrogen (E2) stimulates tumour growth of oestrogen receptor (ER) positive breast cancer and is involved in the pathogenesis of the disease. Consequently, therapeutic approaches targeting the ER were developed. The use of endocrine therapy is an integral component in treating breast cancer however resistance to such drugs is a major limitation. Unfortunately, even initially responding tumours eventually develop resistance - acquired resistance.

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Skerry, Benjamin James Oliver. "Investigating epigenetic mechanisms of acquired endocrine resistance in an in vitro model of breast cancer." Thesis, University of Edinburgh, 2013. http://hdl.handle.net/1842/8106.

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I have investigated epigenetic mechanisms of acquired endocrine-resistance in breast cancer using an in vitro model system based on estrogen-dependent MCF7 cells and their derivatives, LCC1 and LCC9. LCC1 cells, derived from MCF7 after passage in ovariectomised mice and routinely cultured in vitro in the absence of estrogen, exhibit estrogen-independent growth. They retain sensitivity to tamoxifen and fulvestrant. LCC9 cells, derived from LCC1 cells by growing them in increasing concentrations of fulvestrant, are completely estrogen-independent and are resistant to fulvestrant and cross-resist

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21

Rautio, K. (Katriina). "Effects of insulin-lowering drugs in PCOS: endocrine, metabolic and inflammatory aspects." Doctoral thesis, University of Oulu, 2006. http://urn.fi/urn:isbn:951428268X.

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Abstract Most women with polycystic ovary syndrome (PCOS) exhibit features of metabolic syndrome, including insulin resistance, abdominal obesity, dyslipidaemia, glucose intolerance and low-grade chronic inflammation, reflected in elevated levels of serum C-reactive protein (CRP), placing these women at increased risk of cardiovascular disease and type 2 diabetes (type 2 DM). The aim of this study was to investigate the effects of two well-known insulin-lowering drugs used in the treatment of type 2 DM, metformin and rosiglitazone, on traditional cardiovascular risk factors and inflammation i

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22

Ek, Ingvar. "Polycystic ovary syndrome : a study of adipocyte lipolysis in relation to endocrine and metabolic status /." Stockholm, 2003. http://diss.kib.ki.se/2003/91-7349-562-x/.

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Morgan, Liam David. "Elevated Src kinase activity accompanies endocrine-resistance in breast cancer and promotes an aggressive cell phenotype." Thesis, Cardiff University, 2007. http://orca.cf.ac.uk/55686/.

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Despite the effectiveness of tamoxifen in the treatment of oestrogen-receptor-positive breast cancer, a significant proportion of initially-responsive tumours will develop resistance. Using an in vitro cell-model (Tam-R), our laboratory has previously demonstrated that altered growth-factor signalling contributes to tamoxifen-resistant growth. Furthermore, preliminary studies have revealed that acquired tamoxifen-resistance is also accompanied by an aggressive cell-phenotype. Src plays a key role in the regulation of cellular events such as proliferation, migration and invasion. Given that Src

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Bernards, Jake. "An Investigation into Fatigue Management: Effects of Two Different Loading Protocols on Markers of Inflammation and the Endocrine Response." Digital Commons @ East Tennessee State University, 2018. https://dc.etsu.edu/etd/3445.

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The purposes of this dissertation were to 1) determine the effectiveness of the neutrophillymphocyte ratio (NLR) as an athlete monitoring tool in resistance training and 2) determine if repetition maximum or relative intensity loading scheme is superior in managing fatigue through the hormonal, inflammatory, and performances response throughout a 10-week periodized resistance training program. Results from the dissertation give merit to continued research regarding the use of NLR as a monitoring tool to help determine the degree of recovery. Furthermore, results from this dissertation lead to

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LORITO, NICLA. "Metabolic determinants of therapy resistance in estrogen receptor positive breast cancer." Doctoral thesis, Università di Siena, 2021. http://hdl.handle.net/11365/1128634.

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The majority of breast cancers are estrogen receptor positive (ER+) and epidermal growth factor receptor two negative (HER2-) and are dependent on estrogens for their growth and survival. Endocrine therapy (ET), which acts by targeting the ER signaling pathway, is the standard of care for these tumors. Unfortunately, ~40% of women relapse with ET resistant disease and understanding the metabolic reprogramming underlying such resistance is an important need. In the first part of this thesis, we performed a global gene expression analysis in ET resistant compared to parental cells revealing a do

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SPAGNOLO, VANESSA. "EFFECT OF FASTING MIMICKING CONDITIONS ON HORMONE THERAPY EFFICACY AND RESISTANCE ACQUISITION IN BREAST CANCER." Doctoral thesis, Università degli Studi di Milano, 2019. http://hdl.handle.net/2434/609701.

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The most common cancer diagnosed among women worldwide is breast cancer (BC) with 60-80% belonging to the ER+BC subtype. Development of resistance is the major driver of ER+BC-related death. Well-tolerated treatments that allow concomitant targeting of the heterogeneous cancer cells are needed in order to abolish resistance. Fasting and fasting mimicking diets (FMD’s), acting in a broad way, have shown great potential to protect the healthy cells of the body during chemotherapeutic treatment, while augmenting treatment efficacy, mainly through lowered levels of blood glucose and circulating In

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Borgoni, Simone [Verfasser], and Stefan [Akademischer Betreuer] Wiemann. "Time-resolved profiling reveals ATF3 as a novel mediator of endocrine resistance in breast cancer / Simone Borgoni ; Betreuer: Stefan Wiemann." Heidelberg : Universitätsbibliothek Heidelberg, 2020. http://d-nb.info/1224356276/34.

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Jehanno, Charly. "Régulation de l'activité de récepteur alpha des oestrogènes (ERα) par l'hypoxie et le facteur MKL1 dans un modèle de cellules cancéreuses mammaires". Thesis, Rennes 1, 2017. http://www.theses.fr/2017REN1B050/document.

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Les œstrogènes, et en particulier l’œstradiol E2, régulent un nombre considérable de fonctions physiologiques au sein de l’organisme et permettent notamment l’établissement et le maintien des fonctions reproductives chez tous les vertébrés. L’E2 agit localement dans de multiples organes cibles via l’intermédiaire de ses récepteurs : ERα et ERβ. Par son action proliférative contribuant au renouvellement de l’épithélium mammaire, l’E2 ainsi que son récepteur ERα ont été associés au développement pathologique de tumeurs mammaires. Celles-ci sont qualifiées d’hormono-dépendantes car elles réponden

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Cottu, Paul-Henri. "Caractérisation moléculaire de la résistance à l’hormonothérapie et au ciblage de la voie PI3K/mTOR dans des modèles murins de cancers du sein luminaux." Thesis, Université Paris-Saclay (ComUE), 2015. http://www.theses.fr/2015SACLS114/document.

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Les cancers du sein luminaux, exprimant le récepteur aux œstrogènes (RE) représentent 65-75% des cancers du sein soit environ 35.000 nouvelles patientes par an en France. Les référentiels thérapeutiques en vigueur recommandent une prescription systématique d’hormonothérapie au stade précoce, et quasiment constante au stade avancé. Néanmoins, il est admis que plus de 20% des patientes au stade précoce, et la quasi-totalité au stade avancé, vont échapper au traitement endocrinien, rendant impératif le développement de modèles précliniques permettant d’étudier les mécanismes d’hormonorésistance.

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Pearson, Todd. "The Genetic Basis of Resistance to Transplantation Tolerance Induced by Costimulation Blockade in NOD Mice: a Dissertation." eScholarship@UMMS, 2003. https://escholarship.umassmed.edu/gsbs_diss/16.

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The NOD mouse is a widely studied model of type 1 diabetes. The loss of self-tolerance leading to autoimmune diabetes in NOD mice involves at least 27 genetic loci. Curing type I diabetes in mice and humans by islet transplantation requires overcoming both allorejection and recurrent autoimmunity. This has been achieved with systemic immunosuppression, but tolerance induction would be preferable. In addition to their genetic defects in self-tolerance, NOD mice resist peripheral transplantation tolerance induced by costimulation blockade using donor-specific transfusion and anti-CDl54 antibody.

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Micallef, Rachel Antonia. "Wnt signalling in endocrine resistant breast cancer." Thesis, Cardiff University, 2012. http://orca.cf.ac.uk/41274/.

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Wnt signalling components are reported to be deregulated in breast cancer but the contribution of this pathway in endocrine resistance is less clearly defined. Endocrine resistance is an important clinical challenge affecting up to a quarter of all breast cancer patients and is associated with a poorer clinical prognosis. This project focussed on exploring the role of Wnt signalling in endocrine resistant breast cancer cell models. Wnt pathway elements were deregulated in the acquired tamoxifen resistant cell line (Tam-R) compared to tamoxifen sensitive parental cells (MCF-7), with changes sup

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Rajalekshmi, Devi Sarika. "Development of Novel anti-estrogens for endocrine resistant Breast Cancer." Thesis, Virginia Tech, 2016. http://hdl.handle.net/10919/81275.

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ER+ breast cancer raises a significant diagnostic challenge since resistance invariably develops to the current endocrine therapies. 70% of breast cancers are ER+, which results from the overexpression of estrogen receptor. ER mediates strong anti-inflammatory signaling in ER+ tissues. Once activated with estradiol (E2), ER inhibits inflammatory gene expression via protein-protein interactions that block NF-kappa B transcriptional activity. Importantly, NF-kappa B is a primary mediator of resistance in many cancers, including breast cancer. All current endocrine suppressive treatments block th

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McAdler, Marisa M. "The Relationship Between Vitamin D Status of Adult Women and Diet, Sun Exposure, Skin Reflectance, Body Composition, and Insulin Sensitivity." DigitalCommons@CalPoly, 2013. https://digitalcommons.calpoly.edu/theses/1090.

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As the prevalence of vitamin D deficiency continues to grow, mounting evidence supporting its link with chronic disease strengthens suggesting vitamin D’s candidacy in the prevention and treatment of multiple disease states and their complications. Dietary guidelines, however, do not take sun exposure into account. The present study sought to explore the impact of sun exposure on vitamin D status (serum 25(OH)D), and identify other significant determinants of serum levels which may have the greatest effects on overall health. Participants (n = 34) were pre-menopausal women aged 18 to 50 years

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Bryan, R. A. "The role of androgen receptor signalling in endocrine resistant breast cancer." Thesis, University of Essex, 2018. http://repository.essex.ac.uk/22355/.

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Breast cancer (BCa) is the most prevalent cancer among women in the UK. The majority of BCas are endocrine sensitive and develop through the action of oestrogens, facilitated through the transcription factor Oestrogen Receptor alpha (ERα). Treatment for these patients usually involves endocrine therapies (Aromatase Inhibitors and antioestrogens), which are successful in many patients, but therapy resistance represents a major clinical issue. The Androgen Receptor (AR) is a transcription factor that is more highly expressed than ERα in BCa, and mediates the functions of androgens. In early form

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Hagan, G. Nana. "Adipocyte Insulin-Mediated Glucose Transport: The Role of Myosin 1c, and a Method for in vivo Investigation: A Dissertation." eScholarship@UMMS, 2008. https://escholarship.umassmed.edu/gsbs_diss/403.

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The importance of insulin delivery and action is best characterized in Type 2 Diabetes, a disease that is becoming a pandemic both nationally and globally. Obesity is a principal risk factor for Type 2 Diabetes, and adipocyte function abnormalities due to adipose hypertrophy and hyperplasia, have been linked to obesity. Numerous reports suggest that the intracellular and systemic consequences of adipocyte function abnormalities include adipocyte insulin resistance, enhanced production of free fatty acids, and production of inflammatory mediators. A hallmark of adipocyte insulin sensitivity is

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Li, Zhuo. "Modulation of IGFBP2 upon aging, obesity and insulin resistance in mice and humans." Thesis, Université Laval, 2011. http://www.theses.ulaval.ca/2011/28371/28371.pdf.

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Sivanandan, Kavitta. "Role of forkhead transcription factors in endocrine sensitive and resistant breast cancer cell lines." Thesis, Imperial College London, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.522211.

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Shi, Xiarong. "Mitochondrial Dysfunction and AKT Isoform-Specific Regulation in 3T3-L1 Adipocytes: A Dissertation." eScholarship@UMMS, 2010. https://escholarship.umassmed.edu/gsbs_diss/505.

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Excess food consumption and/or lack of exercise have dramatically contributed to the prevalence of overweight (BMI≥25) and obesity (BMI≥30) in modern society. The obesity epidemic has been linked to the rise in type 2 diabetes. In recent years, evidence has pointed to a close association between mitochondrial dysfunction in white adipose tissue (WAT) and insulin resistance, a key feature of type 2 diabetes. In order to dissect the cause and effect relationship between WAT mitochondrial dysfunction and insulin resistance, we established an in vitro cell line system to investigate this issue. We

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Vilquin, Paul. "Événements moléculaires associés à la résistance acquise aux anti-aromatases dans le cancer du sein hormono-dépendant : voie de survie PI3K/Akt/mTOR : profils d'expression spécifiques de miRNAs." Thesis, Lyon 1, 2013. http://www.theses.fr/2013LYO10295.

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La résistance aux anti-aromatases (AAs) constitue un obstacle thérapeutique majeur dans le traitement des cancers du sein RE+. Les objectifs de ce travail étaient : (i) de caractériser les événements moléculaires associés à la résistance acquise aux AAs ; (ii) d’identifier de manière globale de nouveaux profils de miRNAs spécifiquement associés à la résistance aux AAs. Notre étude a mis en évidence le rôle central de la voie Akt/mTOR dans la résistance acquise et de novo aux AAs dans des modèles cellulaires, mais également dans des échantillons de patientes ayant récidivé sous anastrozole. La

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Kergoat, Micheline. "Secretion et mode d'action de l'insuline dans un modele de diabete non-insulinodependant chez le rat." Paris 7, 1988. http://www.theses.fr/1988PA077085.

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Young, James L. "Innate Immunity in Type 2 Diabetes Pathogenesis: Role of the Lipopolysaccharide Signaling Cascade: A Dissertation." eScholarship@UMMS, 2008. https://escholarship.umassmed.edu/gsbs_diss/400.

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Once seen as a disease of wealthy nations, type 2 diabetes mellitus is now showing unprecedented growth throughout the world, fueling increases in microvascular and macrovascular complications. A compelling and growing body of evidence suggests that glucose intolerance and insulin resistance, hallmarks of the diabetic patient, may be driven by chronic inflammation. In particular, a predominance of visceral fat has been associated with enhanced inflammatory cytokine secretion that may contribute to enhanced risk of diabetes and comorbid cardiovascular disease in these individuals. As a function

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Britton, David J. "Role of oestrogen receptor phosphorylation in the growth of endocrine-responsive and anti-oestrogen-resistant breast cancer cell lines." Thesis, Cardiff University, 2005. http://orca.cf.ac.uk/54251/.

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EGFR/MAPK signalling has been implicated in mediating tamoxifen-resistant breast cancer cell growth in the clinic and in preclinical models. However, ERa expression and functionality has also been shown to be maintained in this condition. ERa transcriptional activity can be driven, in a tigand-independent manner, via growth factor signalling-mediated phosphorylation of ERa. The aim of mis thesis was to investigate whether growth factor signalling pathways regulate phosphorylation and functionality of ERa in tamoxifen-sensitive (WT) and -resistant (TAM-R) MCF-7 breast cancer cell lines and if s

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Neto, João Francisco Ribeiro Furtado. "Prevalência da síndrome metabólica em adolescentes de 06 Escolas na Cidade de São Luís/MA Brasil." Universidade do Estado do Rio de Janeiro, 2013. http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=6713.

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Na população pediátrica tem aumentado a prevalência da Síndrome Metabólica. No Brasil, poucos estudos foram realizados em relação a sua prevalência, critérios de diagnósticos, principalmente no Norte/Nordeste. Apesar de não termos uma definição oficial para a Síndrome Metabólica em adolescentes, utilizamos critérios da NCEP ATP III modificados que consistiram em: Obesidade Abdominal >= 90 percentil, HDL-colesterol <= 40 mg/dl, Triglicerídeo > = 110 mg/dl, Glicemia em Jejum >= 100 mg/dl, Pressão Arterial >= 90 percentil ajustável para idade e gênero. Participaram deste estudo 468 adolescentes s

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Sebastiani, Giorgia. "Repercusiones endocrino-metabólicas del bajo peso al nacer: influencia de la alimentación precoz y del crecimiento post-natal." Doctoral thesis, Universitat de Barcelona, 2016. http://hdl.handle.net/10803/405572.

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INTRODUCCION Según la teoría del “Programming”, la asociación entre bajo peso al nacer para la edad gestacional (PEG), desarrollo de enfermedad coronaria en la edad adulta y síndrome metabólico (SM) caracterizado por resistencia a la insulina y exceso de adiposidad central y visceral, ocurre fundamentalmente en individuos PEG que desarrollan un “catch-up” rápido y exagerado durante los primeros meses de vida postnatal. El tejido adiposo (TA) juega un papel fundamental en el desarrollo del SM: según la teoría de expansibilidad del TA si se excede su máxima capacidad de almacenamiento este se v

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De, Nigris Valeria. "The possible link between high glucose-induced PKCβ expression and the appearance of GLP-1 resistance in endothelial cells". Doctoral thesis, Universitat de Barcelona, 2015. http://hdl.handle.net/10803/325682.

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INTRODUCTION. It has been demonstrated that Glucagon-like peptide-1 (GPL-1) has a protective effect on endothelial cells. GLP-1 improves endothelial function in diabetes, however the mechanisms underlying the GLP-1 protective effects have not yet been fully elucidated. Additionally, it has been proposed that GLP-1 could restore high glucose - endoplasmic reticulum (ER) stress induction. Recent evidences claim a resistance of GLP-1 action that has been shown in pancreatic 13-cells of diabetic patients. A proposed mechanism to explain this resistance to the GLP-1 action in diabetes is the activa

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Thomas, Amandine. "Hypoxie intermittente et homéostasie glucidique : étude des mécanismes d'action cellulaire A hybrid model to study pathological mutations of the human ADP/ATP carriers Visceral white fat remodeling contributes to intermittent hypoxia-induced atherogenesis The insulin sensitizing effect of topiramate involves KATP channel activation in the central nervous system The Impact of Sleep Disorders on Glucose Metabolism: Endocrine and Molecular Mechanisms Endoplasmic reticulum stress as a novel inducer of hypoxia inducible factor-1 activity: its role in the susceptibility to myocardial ischemia-reperfusion induced by chronic intermittent hypoxia Chronic intermittent hypoxia improves whole-body glucose tolerance by activating skeletal muscle AMP-activated protein kinase in mice Prolyl-4-hydroxylase 1 (PHD1) deficiency impairs whole-body glucose tolerance and insulin sensitivity in mice but does not worsen high-fat diet-induced metabolic dysfunctions Specific transcriptomic signature in response to intermittent hypoxia exposure in liver and fat tissue." Thesis, Université Grenoble Alpes (ComUE), 2015. http://www.theses.fr/2015GREAV044.

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L'hypoxie intermittente (HI), induite par les apnées du sommeil, conduit à des altérations de la sensibilité à l'insuline et de l'homéostasie glucidique mais les mécanismes impliqués restent mal connus. L'objectif de ce travail était d'étudier les effets et les mécanismes sous jacents d'une exposition chronique à l'HI sur l'homéostasie glucidique. L'HI induit une résistance à l'insuline à la fois systémique et tissulaire, ainsi qu'une amélioration de la tolérance au glucose associée à une activation de l'AMPK musculaire. L'HI cause également des altérations du foie et du tissu adipeux associée

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Toste, Fernanda Pereira. "A composição corporal, resistência à leptina e função tireóidea são programadas em ratos cujas mães foram tratadas com leptina no início da lactação." Universidade do Estado do Rio de Janeiro, 2008. http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=1147.

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior<br>A morbidade e mortalidade por doenças cardiovasculares demonstram tendência geral de declínio, mas, em países em desenvolvimento como o Brasil a ocorrência destes eventos é crescente. A obesidade e principalmente a localização intra-abdominal de gordura, relaciona-se com a ocorrência de doença crônica e diferentes tipos de dietas tem sido testados na busca pela efetiva redução da adiposidade. Fatores biológicos como a resistência à insulina pode interferir na resposta obtida com intervenções nutricionais. O objetivo deste estudo fo

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Silva, Andreia Marisa Ribeiro da. "Endocrine Resistance and Notch Signalling Pathway in Breast Cancer." Master's thesis, 2013. https://repositorio-aberto.up.pt/handle/10216/89949.

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Silva, Andreia Marisa Ribeiro da. "Endocrine Resistance and Notch Signalling Pathway in Breast Cancer." Dissertação, 2013. https://repositorio-aberto.up.pt/handle/10216/89949.

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Alves, Carla Maria Lourenço 1985. "Characterization and functional analysis of biomarkers in endocrine resistance of breast cancer treatment." Master's thesis, 2013. http://hdl.handle.net/10451/9622.

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Tese de mestrado. Biologia (Biologia Molecular e Genética). Universidade de Lisboa, Faculdade de Ciências, 2013<br>Estrogen receptor positive (ER+) breast cancer accounts for over 80% of breast tumors and these patients are eligible for endocrine therapy. Despite the efficacy of endocrine treatment many breast cancer patients experience recurrence or disease progression as a result of de novo or acquired resistance. Fulvestrant is a relatively recent anti-estrogen drug used in the treatment of advanced ER+ breast cancer, however resistance to this drug also occur in breast cancer patients. The

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