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Rozprawy doktorskie na temat „Endpoints”

Autor: Grafiati

Data publikacji: 4 czerwca 2021

Data aktualizacji: 4 lutego 2022

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1

Weaver, Jean M. "Molecular pharmacodynamic endpoints /." The Ohio State University, 1997. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487945320761452.

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Liu, Yi. "Testing for Efficacy for Primary and Secondary Endpoints by Partitioning Decision Paths." The Ohio State University, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=osu1259598621.

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Izadinia, Vafa Dario. "Fingerprinting Encrypted Tunnel Endpoints." Diss., University of Pretoria, 2005. http://hdl.handle.net/2263/25351.

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Operating System fingerprinting is a reconnaissance method used by Whitehats and Blackhats alike. Current techniques for fingerprinting do not take into account tunneling protocols, such as IPSec, SSL/TLS, and SSH, which effectively `wrap` network traffic in a ciphertext mantle, thus potentially rendering passive monitoring ineffectual. Whether encryption makes VPN tunnel endpoints immune to fingerprinting, or yields the encrypted contents of the VPN tunnel entirely indistinguishable, is a topic that has received modest coverage in academic literature. This study addresses these question by ta

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4

Feng, Chunyao Seaman John Weldon. "Bayesian evaluation of surrogate endpoints." Waco, Tex. : Baylor University, 2006. http://hdl.handle.net/2104/4187.

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5

Nordman, Ina IC Clinical School St Vincent's Hospital Faculty of Medicine UNSW. "Surrogate endpoints of survival in metastatic carcinoma." Publisher:University of New South Wales. Clinical School - St Vincent's Hospital, 2008. http://handle.unsw.edu.au/1959.4/42791.

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In most randomised controlled trials (RCTs), a large number of patients need to be followed over many years, for the clinical benefit of the drug to be accurately quantified (1). Using an early proxy, or a surrogate endpoint, in place of the direct endpoint of overall survival (OS) could theoretically shorten the duration of RCTs and minimise the exposure of patients to ineffective or toxic treatments (2, 3). This thesis examined the relationship between surrogate endpoints and OS in metastatic colorectal cancer (CRC), advanced non-small cell lung cancer (NSCLC) and metastatic breast cancer (M

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6

Studer, Ahren M. "Verifying Physical Endpoints to Secure Digital Systems." Research Showcase @ CMU, 2011. http://repository.cmu.edu/dissertations/77.

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The proliferation of electronic devices supporting sensing, actuation, and wireless communication enables the monitoring and/or control of a variety of physical systems with digital communication. Such “cyber physical systems” blur the boundaries of the digital and physical worlds, where correct information about the physical world is needed for the correct operation of the digital system. Often in these systems the physical source or destination of information is as important as the information itself. However, the omni-directional and invisible nature of wireless communication makes it diffi

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7

Cooney, Maureen Anne Siega-Riz Anna Maria. "In utero environmental exposures and reproductive endpoints." Chapel Hill, N.C. : University of North Carolina at Chapel Hill, 2008. http://dc.lib.unc.edu/u?/etd,2433.

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Thesis (Ph. D.)--University of North Carolina at Chapel Hill, 2009.<br>Title from electronic title page (viewed Sep. 3, 2009). "... in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the Department of Epidemiology." Discipline: Epidemiology; Department/School: Public Health.

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8

Alhabib, Nada. "Explosion of escaping endpoints of exponential maps." Thesis, University of Liverpool, 2016. http://livrepository.liverpool.ac.uk/3001508/.

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9

Del, Gobbo Liana. "Magnesium biomarkers and cardiometabolic endpoints in multiethnic populations." Thesis, McGill University, 2012. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=107839.

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Background: Magnesium (Mg) is known to exert diverse actions on cardiometabolic function; suboptimal Mg intake and status may contribute significantly to adverse metabolic and cardiovascular health. While type 2 diabetes mellitus (T2DM) is the most common cause of Mg depletion, research gaps exist regarding the potential influence of transient states of impaired glycemia, such as gestational diabetes, on Mg biomarkers in affected mothers or their offspring. Further, whether or not diabetes is an important effect modifier of associations between Mg biomarkers and cardiovascular endpoints, such

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10

Blatchford, Patrick Judson. "Monitoring bivariate endpoints in group sequential clinical trials /." Connect to full text via ProQuest. Limited to UCD Anschutz Medical Campus, 2007.

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Thesis (Ph.D. in Biostatistics) -- University of Colorado Denver, 2007.<br>Typescript. Includes bibliographical references (leaves 104-106). Free to UCD affiliates. Online version available via ProQuest Digital Dissertations;

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11

Haihambo, Paulus. "Hyperconvexity and endpoints in T₀-quasi-metric spaces." Master's thesis, University of Cape Town, 2013. http://hdl.handle.net/11427/6617.

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Over the last decades much progress has been made in the investigation of hyperconvexity in metric spaces. Recently Kemajou and others have published an article concerning hyperconvexity in T₀-quasi-metric spaces. In 1964 Isbell introduced and studied the concept of an endpoint of a metric space. The aim of this dissertation is to begin an investigation into hyperconvexity and endpoints of T₀-quasi-metric spaces. It starts off with basic definitions and some well-known properties of quasi-pseudometric spaces. We conclude by commencing an investigation into hyperconvexity and endpoints of T₀-qu

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12

Wang, Hui. "Response Adaptive Randomization using Surrogate and Primary Endpoints." VCU Scholars Compass, 2016. http://scholarscompass.vcu.edu/etd/4517.

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In recent years, adaptive designs in clinical trials have been attractive due to their efficiency and flexibility. Response adaptive randomization procedures in phase II or III clinical trials are proposed to appeal ethical concerns by skewing the probability of patient assignments based on the responses obtained thus far, so that more patients will be assigned to a superior treatment group. General response-adaptive randomizations usually assume that the primary endpoint can be obtained quickly after the treatment. However, in real clinical trials, the primary outcome is delayed, making it un

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13

James, Susan Elizabeth. "The analysis of multiple endpoints in clinical trials." Thesis, University of Leicester, 1993. http://hdl.handle.net/2381/34548.

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14

Zain, Zakiyah. "Combining multiple survival endpoints within a single statistical analysis." Thesis, Lancaster University, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.618302.

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The aim of this thesis is to develop methodology for combining multiple endpoints within a single statistical analysis that compares the responses of patients treated with a novel treatment with those of control patients treated conventionally. The focus is on interval-censored bivariate survival data, and five real data sets from previous studies concerning multiple responses are used to illustrate the techniques developed. The background to survival analysis is introduced by a general description of survival data, and an overview of existing methods and underlying models is included. A revie

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15

Sved, Daniel W. "Monooxygenase induction and lethality as endpoints in aquatic toxicology." W&M ScholarWorks, 1991. https://scholarworks.wm.edu/etd/1539616869.

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Spot, Leiostomus xanthurus, were exposed to suspended sediments (&\approx&20 mg/L) contaminated with polycyclic aromatic hydrocarbons (PAH) in a laboratory flow-through system to evaluate the applicability of hepatic ethoxyresorufin O-deethylase (EROD) induction as an indicator of PAH exposure. PAH sources tested were coal-tar creosote (CTC), a low molecular weight fraction of creosote (LMWF), and a high molecular weight fraction of creosote (HMWF). A standard 96-h acute toxicity test was conducted to ensure that PAH concentrations tested in induction studies were sub-acutely toxic. The 96-h L

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16

Bruce, Erica Dawn. "Modeling toxic endpoints for improving human health risk assessment." [College Station, Tex. : Texas A&M University, 2007. http://hdl.handle.net/1969.1/ETD-TAMU-1277.

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17

Chen, May. "Effects of Chronic Energy Drink Consumption on Cardiometabolic Endpoints." Scholarly Commons, 2020. https://scholarlycommons.pacific.edu/uop_etds/3674.

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Background: Since its introduction in the early 2000s, energy drinks have become increasingly popular among an extensive range of consumers, including adolescents and young adults. Currently, the United States Food and Drug Administration (FDA) does not regulate the formulation of energy drinks, which may vary widely in the amounts of caffeine and sugar, as well as various types of supplements. Recent reports of severe and fatal adverse effects related to energy drinks have led to growing concerns on the safety of energy drink consumption. Objective: This study aimed to investigate the effects

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18

Fergusson, Nicholas Anthony. "Alternative Endpoints and Analysis Techniques in Kidney Transplant Trials." Thesis, Université d'Ottawa / University of Ottawa, 2017. http://hdl.handle.net/10393/36230.

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Clinical trials in kidney transplantation suffer from several major issues including: 1) Unfeasibility due to low short-term event rates of hard outcomes and 2) Reliance on a composite outcome that consists of unequal endpoints that may generate misleading results. This thesis attempts to explore and apply methods to solve these issues and ultimately, improve kidney transplantation trials. We present a secondary analysis of the ACE trial in kidney transplant using composites with alternative graft function surrogate endpoints. Typically, kidney transplant trials—including the ACE trial—

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19

Hellrung, II James Lee. "Labels for Anchors: The Good, the Bad, and the Endpoints." TopSCHOLAR®, 2010. http://digitalcommons.wku.edu/theses/156.

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This study was designed to determine if any differences in internal consistency existed between different designs of scale anchors. The three different designs explored were properly designed scales, improperly designed scales, and endpoint only scales. Two-Hundred and thirty-five participants rated the frequency of which they performed various computer activities on a survey using one of the three different designs. Contrary to expectations, internal consistency did not differ across the three designs.

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20

Powell, Christine Louise Rusyn Ivan. "Improving linkage of hepatic toxicity and pathology endpoints with toxicogenomics." Chapel Hill, N.C. : University of North Carolina at Chapel Hill, 2007. http://dc.lib.unc.edu/u?/etd,997.

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Thesis (Ph. D.)--University of North Carolina at Chapel Hill, 2007.<br>Title from electronic title page (viewed Dec. 18, 2007). "... in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the Curriculum in Toxicology." Discipline: Toxicology; Department/School: Medicine.

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21

Luo, Yingchun. "Nonparametric statistical procedures for therapeutic clinical trials with survival endpoints." Thesis, Kingston, Ont. : [s.n.], 2007. http://hdl.handle.net/1974/492.

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22

Rossouw, Maria Susanna. "Validation of endpoints as biomarkers of low-dose radiation damage." Thesis, Cape Technikon, 2004. http://hdl.handle.net/20.500.11838/1461.

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Thesis (MTech (Biomedical Technology))--Cape Technikon, Cape Town, 2004<br>The need for radiobiological research was bom from the discovery that high doses of radiation could cause cancer and other health effects. However, recent developments in molecular biology uncovered the effects of low doses of radiation on different biological systems and as a result new techniques have been developed to measure these effects. The aim of this study was thus to validate biomarkers of initial DNA strand breaks, micronucleus formation, and the different pt ;ases of apoptosis as biological indic

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23

Wang, Wenbin. "HDACi-induced DNA damage : identifying potential endpoints for safety assessment." Thesis, Cardiff University, 2016. http://orca.cf.ac.uk/98927/.

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Histone deacetylase inhibitors (HDACi) have been designed to alter the actions of epigenetic modifiers with the aim of 'reprogramming' the epigenome of diseased tissues back to their normal disease-free state. These inhibitors were designed to be non-DNA reactive and therefore considered safe from a genetic toxicology point of view. However, HDACi’s have been shown to induce DNA damage in healthy cells through unknown mechanisms, thereby posing significant risks to human health. Studies suggest that HDAC inhibitor-induced DNA damage is partly associated with changes in transcription and replic

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24

Richert, Laura. "Trial design and analysis of endpoints in HIV vaccine trials." Thesis, Bordeaux 2, 2013. http://www.theses.fr/2013BOR22048/document.

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Des données complexes sont fréquentes dans les essais cliniques récents et nécessitent des méthodes statistiques adaptées. La recherche vaccinale du VIH est un exemple d’un domaine avec des données complexes et une absence de critères de jugement validés dans les essais précoces. Cette thèse d’Université concerne des recherches méthodologiques sur la conception et les aspects statistiques des essais cliniques vaccinaux du VIH, en particulier sur les critères de jugement d’immunogénicité et les schémas d’essai de phase I-II. A l’aide des données cytokiniques multiplex, nous illustrons les aspec

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25

Baurne, Yvette. "Nonparametric Combination Methodology : A Better Way to Handle Composite Endpoints?" Thesis, Uppsala universitet, Statistiska institutionen, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-274959.

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Composite endpoints are widely used in clinical trials. The outcome of a clinical trial can affect many individuals and it is therefore of importance that the methods used are as effective and correct as possible. Improvements of the standard method of testing composite endpoints have been proposed and in this thesis, the alternative method using nonparametric combination methodology is compared to the standard method. Performing a simulation study, the power of three combining functions (Fisher, Tippett and the Logistic) are compared to the power of the standard method. The performances of th

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26

Lu, Qingshu. "Statistical analysis for two-stage adaptive designs with different study endpoints /." access full-text access abstract and table of contents, 2009. http://libweb.cityu.edu.hk/cgi-bin/ezdb/thesis.pl?phd-ms-b30082766f.pdf.

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Thesis (Ph.D.)--City University of Hong Kong, 2009.<br>"Submitted to Department of Management Science in partial fulfillment of the requirements for the degree of Doctor of Philosophy." Includes bibliographical references (leaves 126-130)

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27

Das, Ashish. "Development of Energy-Based Endpoints for diagnosis of Pulmonary Valve Insufficiency." University of Cincinnati / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1384864758.

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Bark, Charles. "CLINICAL SYMPTOMS AND MICROBIOLOGICAL OUTCOMES IN TUBERCULOSIS TREATMENT TRIALS." Case Western Reserve University School of Graduate Studies / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=case1307630776.

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29

Gómez-Mateu, Moisés. "Composite endpoints in clinical trials : computational tools, practical guidelines and methodological extensions." Doctoral thesis, Universitat Politècnica de Catalunya, 2016. http://hdl.handle.net/10803/396263.

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The conclusions from randomized clinical trials (RCT) rely on the primary endpoint (PE), which is chosen at the design stage of the study; thus, it is of utmost importance to select it appropriately. In RCT, there should generally be only one PE, and it should be able to provide the most clinically relevant and scientific evidence regarding the potential efficacy of the new treatment. Composite endpoints (CE) consist of the union of two or more outcomes and are often used in RCT. When the focus is time-to-event analysis, CE refer to the elapse time from randomization until the first component

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30

Carrió, Gaspar Pau 1982. "Development of advanced strategies for the prediction of toxicity endpoints in drug development." Doctoral thesis, Universitat Pompeu Fabra, 2015. http://hdl.handle.net/10803/328418.

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Safety concerns are one of the main causes of drug attrition. In these events, the moment at which the drug toxic effects are discovered changes dramatically the importance of the finding; discarding a valuable candidate at clinical testing stages means wasting years of efforts and huge economicinvestments. Even more dramatic is the discovery of toxic effect at post marketing stages, when the drug could have already produced severe side effects on a number of patients. For these reason there is a pushing need of developing methods able to assess the safety of drug candidates at early stage

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31

Lessigiarska, Iglika. "Development of structure-activity relationships for pharmacotoxicological endpoints relevant to European Union legislation." Thesis, Liverpool John Moores University, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.436564.

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32

Saxena, Akriti. "A SEQUENTIAL ALGORITHM TO IDENTIFY THE MIXING ENDPOINTS IN LIQUIDS IN PHARMACEUTICAL APPLICATIONS." VCU Scholars Compass, 2009. http://scholarscompass.vcu.edu/etd/1931.

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The objective of this thesis is to develop a sequential algorithm to determine accurately and quickly, at which point in time a product is well mixed or reaches a steady state plateau, in terms of the Refractive Index (RI). An algorithm using sequential non-linear model fitting and prediction is proposed. A simulation study representing typical scenarios in a liquid manufacturing process in pharmaceutical industries was performed to evaluate the proposed algorithm. The data simulated included autocorrelated normal errors and used the Gompertz model. A set of 27 different combinations of the p

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33

Liu, Meng. "A PREDICTIVE PROBABILITY INTERIM DESIGN FOR PHASE II CLINICAL TRIALS WITH CONTINUOUS ENDPOINTS." UKnowledge, 2017. http://uknowledge.uky.edu/epb_etds/15.

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Phase II clinical trials aim to potentially screen out ineffective and identify effective therapies to move forward to randomized phase III trials. Single-arm studies remain the most utilized design in phase II oncology trials, especially in scenarios where a randomized design is simply not practical. Due to concerns regarding excessive toxicity or ineffective new treatment strategies, interim analyses are typically incorporated in the trial, and the choice of statistical methods mainly depends on the type of primary endpoints. For oncology trials, the most common primary objectives in phase I

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34

Ntambwe, Lupetu Ives. "Sequential sample size re-estimation in clinical trials with multiple co-primary endpoints." Thesis, University of Warwick, 2014. http://wrap.warwick.ac.uk/66339/.

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In this thesis, we consider interim sample size adjustment in clinical trials with multiple co-primary continuous endpoints. We aim to answer two questions: First, how to adjust a sample size in clinical trial with multiple continuous co-primary endpoints using adaptive and group sequential design. Second, how to construct a test in order to control the family-wise type I error rate and maintain the power, even if the correlation ρ between endpoints is not known. To answer the first question, we conduct K different interim tests, each for one endpoint and each at level α/K (i.e. Bonferroni adj

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35

Pallmann, Philip Steffen [Verfasser]. "Multiple contrast tests with repeated and multiple endpoints : with biological applications / Philip Steffen Pallmann." Hannover : Technische Informationsbibliothek (TIB), 2016. http://d-nb.info/1112948635/34.

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36

Poppel, Gerardus Arnoldus Franciscus Catharina van. "Beta-carotene and cancer risk a trial in smokers using biomarkers as intermediate endpoints /." Maastricht : Maastricht : Rijksuniversiteit Limburg ; University Library, Maastricht University [Host], 1994. http://arno.unimaas.nl/show.cgi?fid=5908.

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37

Sundaram, Supriya. "Characterisation of exacerbations in non-CF bronchiectasis to establish endpoints in measuring treatment efficacy." Thesis, University of East Anglia, 2013. https://ueaeprints.uea.ac.uk/50709/.

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Bronchiectasis is characterised by chronic cough productive of mucopurulent sputum and frequent exacerbations. We have aimed to validate clinical, biochemical and microbiological endpoints to aid planning of future interventional studies. We recruited fifty-eight subjects with bronchiectasis at the Lung Defence unit (Papworth Hospital, Cambridge) and studied them in stable state (no exacerbation in the preceding four weeks) and during an exacerbation over a period of two years. The results of our research are discussed in this study. Clinical symptoms: Cough chest pain, chest discomfort, colou

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38

Mazzotti, Andrea. "Analisi e sviluppo di un engine per l'interrogazione di endpoints SPARQL tramite linguaggio naturale." Bachelor's thesis, Alma Mater Studiorum - Università di Bologna, 2012. http://amslaurea.unibo.it/4179/.

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39

Farhat, Naha. "Design and Analysis of Toxicological Experiments with Multiple Endpoints and Synergistic and Inhibitory Effects." VCU Scholars Compass, 2014. https://scholarscompass.vcu.edu/etd/636.

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The enormous increase of exposure to toxic materials and hazardous chemicals in recent years is a major concern due to the adverse effect resulting from such exposure on human health specifically and all organisms in general. Among the major concerns of toxicologists is to determine an acceptable level(s) of exposure to such hazardous substance(s). Current approaches often evaluate each endpoint and stressor individually. Herein we propose two novel approaches to simultaneously determine the Benchmark Dose Tolerable Region (BMDTR) for multiple endpoints and multiple stressors studies when stre

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40

Krishnamoorthy, Mahesh kumaar. "Investigations on Linkages Between Blood Flow Dynamics and Histological Endpoints in Dialysis Access Fistula." University of Cincinnati / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1267718697.

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41

Lee, Namheon. "Assessment of Pulmonary Insufficiency using Energy-Based Endpoints and 4D Phase Contrast MR Imaging." University of Cincinnati / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1384865927.

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42

Michelson, Maximilian. "Client controlled, secure endpointto-endpoint storage in the cloud." Thesis, KTH, Hälsoinformatik och logistik, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-278069.

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Abstract Softronic's customers do not want them to store sensitive data in a cloud environment as theydistrust the cloud providers with keeping sensitive data secret and are afraid of violating GDPR.Softronic wants to prove that data can be kept protected using encryption, even though it is storedin a cloud, and the goal of this thesis is to find a cryptographic solution with good security and performance. The chosen solution was to implement object-level encryption with both encryption and decryptiondone on-site at Softronic with the cloud provider kept outside of the encryption process. Encr

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43

Wente, Stephen P. "Optimizing land acquisition-conversion projects for water quality protection and enhancement using biological integrity endpoints." Virtual Press, 1996. http://liblink.bsu.edu/uhtbin/catkey/1036190.

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Biological monitoring and land use data analysis were performed for a small (79,800 acre) watershed in west-central Indiana. A model was developed between Hilsenhoff biotic index and percentage of water (volume) draining through forestland at each sample site (R2.92, P < .002). This water volume model was found to explain more of the variation in biological integrity than USEPA and Ohio EPA habitat assessment methods, as well as, a land use model based upon percentage watershed surface area. Based on this water volume model, maps were created depicting regions within the watershed that had the

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44

Bruce, Sharon Diane. "Development of rate related exercise-induced myocardial ischemia and risk of selected coronary diesease endpoints." Thesis, This resource online, 1993. http://scholar.lib.vt.edu/theses/available/etd-11102009-020132/.

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Zhou, Bin. "Validity of cerebrospinal fluid biomarkers as endpoints in early-phase clinical trials for Alzheimer disease." Kyoto University, 2009. http://hdl.handle.net/2433/126429.

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46

Chambilla, Aquino Teófilo. "Lenguaje de especificación para la delegación de tareas en Servidores Web mediante agentes." Tesis, Universidad de Chile, 2016. http://repositorio.uchile.cl/handle/2250/139150.

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Magíster en Ciencias, Mención Computación<br>La tecnología de los agentes se ha convertido en la base de una gran cantidad de aplicaciones ya que permite la incorporación de bases de conocimiento de acciones y tareas para resolver problemas complejos. Por otro lado, se sabe que los Servidores Web se sustentan en el protocolo HTTP, protocolo que solo permite las solicitudes y respuestas entre Cliente y Servidor y no delegar funciones a otros Servidores separados geográficamente. Esta investigación consiste en un estudio exploratorio del concepto de la delegación en el contexto de la Web, do

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47

Kugler, Josephine [Verfasser]. "Essential Signaling Cascades as Predictive Endpoints for Teratogenicity in vitro : A Proof of Principle Study / Josephine Kugler." Berlin : Freie Universität Berlin, 2017. http://d-nb.info/1126505056/34.

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48

Ross, Graham Andrew. "An investigation into the biological basis of #late effect' endpoints in the rectum of rats after radiation." Thesis, University of Oxford, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.339103.

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49

Fulton, Rachael Louise. "Exploratory analyses to guide inclusion, limitation of sample size and strengthening of endpoints in clinical stroke trials." Thesis, University of Glasgow, 2013. http://theses.gla.ac.uk/4530/.

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Clinical trials for treatment of acute ischaemic stroke require large numbers of patients and are expensive to conduct. Treatment is typically administered within the first hours or days after stroke onset. Outcome is usually assessed by a single measure, the most common being the modified Rankin scale (mRS) at day 90. Any strategy that can reduce cost or deliver more reliable answers on safety and efficacy of the investigational treatment would be welcome for future exploratory testing of novel treatments. This thesis focused on the impact of applying different methods of design, inclusion an

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Walker, Ann Sarah. "The analysis of multivariate failure time data with application to multiple endpoints in trials in HIV infection." Thesis, University College London (University of London), 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.390624.

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